JP2019077675A - Gel-like external preparation for skin and skin cosmetic - Google Patents

Abstract

To provide a gel-like external preparation for the skin or skin cosmetic which comprises nicotinic acid amide, has an excellent effect of giving a springy feeling and an elastic feeling to the skin, has no sticky feeling and has excellent touch feeling in thickness during application and excellent temporal stability.SOLUTION: There is provided a gel-like external preparation for the skin or skin cosmetic which comprises (A) 1 to 10 mass% of nicotinic acid amide, (B) a silicone oil having a viscosity at 25°C of 25 mPa s or less, (C) one or two or more selected from PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG-10 dimethicone and PEG 12 dimethicone, (D) carboxymethyl cellulose and (E) water, wherein the content mass ratio (B)/(C) of the component (B) to the component (C) is 1 to 5.SELECTED DRAWING: None

Description

  The present invention relates to a gel-like skin external preparation or a skin cosmetic. More specifically, the present invention relates to a gel-like external preparation for skin or a skin cosmetic containing nicotinic acid amide, which improves skin firmness and elasticity, is excellent in thickness during application, has no stickiness, and has excellent stability over time.

  Due to internal factors such as aging and stress, and external factors such as ultraviolet rays and air drying, the skin may cause stains, wrinkles, sags, pigmentation and the like. Among them, morphological changes such as wrinkles and sagging often affect the impression of the appearance, and many people want improvement. Many drugs have been proposed to prevent and improve these wrinkles and sags. Among these, nicotinic acid amide is a vitamin, is highly safe, and is known to have a skin anti-aging effect (Patent Documents 1 and 2). However, it is known that there is an undesirable feeling in use, such as a strong feeling of stickiness if a large amount of nicotinic acid amide is contained, and this improvement has been made (Patent Document 3).

Japanese Patent Application Laid-Open No. 10-130135 JP 10-1414 A Japanese Patent Publication No. 2003-502435

  Patent Document 3, which attempts to suppress the stickiness of nicotinic acid amide, is a technology that contains both a branched hydrocarbon and a highly malleable oil such as a liquid ester emollient, but its effect was insufficient Also, creaming may occur over time, and a problem existed.

  Therefore, the present inventors have combined silicone oil and polyether-modified silicone which can improve the stickiness in water containing a high concentration (1 to 10% by mass) of nicotinic acid amide. We tried to improve the stickiness peculiar to nicotinamide. However, depending on the type of polyether-modified silicone and the content ratio of silicone oil and polyether-modified silicone, sagging may occur due to poor stability over time or poor thickness during coating. There were still cases where the usability was bad. In view of such circumstances, the present inventors have intensively studied to solve the above problems, and as a result, they contain 1 to 10% by weight of nicotinic acid amide, silicone oil having a viscosity of 25 mPa · s or less at 25 ° C, and water. In the composition to be selected, one or more selected from specific polyether modified silicones (PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG-10 dimethicone, PEG-12 dimethicone And the content ratio of silicone oil having a viscosity of 25 mPa · s or less to the specific polyether-modified silicone (silicone oil having a viscosity of 25 mPa · s or less) / (specific polyether-modified silicone) is 1 to 5 Sometimes the stickiness characteristic of nicotinic acid amide is improved and the stability over time is remarkably good. It was found to be in. Furthermore, when the inventors conducted intensive studies as thickeners, when polysaccharides, particularly carboxymethylcellulose, were also included, the temporal stability and the thickness during application were significantly improved, and more surprisingly the skin The present invention has also found that it is possible to provide a gel-like external skin preparation or a skin cosmetic, which has improved the feeling of firmness and elasticity and reduced the feeling of stickiness.

That is, the present invention provides the following components (A) to (E):
(A) Nicotinic acid amide 1 to 10% by mass
(B) Silicone oil having a viscosity of 25 mPa · s or less at 25 ° C. (C) PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG-10 dimethicone, PEG-12 dimethicone Contains one or more (D) carboxymethylcellulose (E) water, and
It is an object of the present invention to provide a gel-like external skin preparation or a skin cosmetic wherein the content ratio by mass of the component (B) to the component (C) (B) / (C) is 1 to 5.

Furthermore, the present invention
It is an object of the present invention to provide a gel-like external skin preparation or a skin cosmetic preparation, wherein the mass ratio (A) / (D) of the component (A) to the component (D) is 20 to 180.

Furthermore, the present invention
It is an object of the present invention to provide a gel-like external skin preparation or a skin cosmetic preparation, wherein the content weight ratio (A) / (C) of the component (A) to the component (C) is 1-12.

Furthermore, the present invention
It is a pre-treatment skin external preparation or a skin cosmetic, and provides a gel-like skin external preparation or a skin cosmetic.

The gel-like skin external preparation or skin cosmetic composition of the present invention improves the feeling of firmness and elasticity of the skin, is excellent in thickness during application, gives excellent feeling of use without stickiness, and is stable over time. It is excellent. Furthermore, as an application of the gel-like skin external preparation or skin cosmetic of the present invention, a pre-treatment skin external preparation or skin cosmetic is preferable. When the gel external preparation for skin or the cosmetic for skin of the present invention is applied as a first agent, when the other external preparation for skin or the cosmetic for skin is used, it is surprising that the external preparation for skin of the second agent or the skin The feeling of penetration at the time of use of cosmetics improved compared with the time of single use, and the absence of sticky feeling after use improved compared with the second agent single use.

  Hereinafter, the present invention will be described in detail. In addition, in this specification, "-" shall mean the range including the numerical value before and behind that.

Component (A): Nicotinamide The component (A) nicotinamide in the present invention is an amide compound of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and a known substance which is one of the vitamin B group, and can be extracted from natural products (such as rice bran) or synthesized by a known method. Specifically, those listed in the 15th Amended Japanese Pharmacopoeia 2008 can be used.

  In the present invention, the content of the component (A) is 1 to 10% by mass (hereinafter, "mass%" is simply abbreviated as "%") in order to improve the feeling of firmness and elasticity of the skin and suppress the feeling of stickiness. 2 to 7% is preferable, and 3 to 6% is more preferable. If the content of the component (A) is less than 1%, the effect of imparting firmness and elasticity to the skin is not excellent, and if it exceeds 10%, the feeling of stickiness at the time of use may be strong and the feeling of use may be bad. .

Component (B): Silicone oil having a viscosity of 25 mPa · s or less at 25 ° C. The silicone oil of component (B) in the present invention has a viscosity of 25 mPa · s or less at 25 ° C.

In the present invention, the viscosity of the component (B) is measured according to the second method of measuring cosmetic raw materials and viscosity using a Brookfield viscometer. The component (B) is not particularly limited, and examples thereof include dimethicone, decamethyltetrasiloxane, octamethyltrisiloxane, trisiloxane, methyltrimethicone and the like having a viscosity of 25 mPa · s or less at 25 ° C. Among them, dimethicone, decamethyltetrasiloxane, and octamethyltrisiloxane having a viscosity of 25 mPa · s or less at 25 ° C. are preferable from the viewpoint of reducing the stickiness of a gel-like external skin preparation or a skin cosmetic preparation. Dimethicone is more preferable, and component (B) can be used alone or in combination of two or more.

The content of the component (B) is not particularly limited, but it is preferably 0.1 to 8%, and 0.2 to 6% from the viewpoint of improving the thickness of the gel external skin preparation or the skin cosmetic during application. More preferably, 0.5 to 5% is more preferable, and 1 to 4% is even more preferable.

The viscosity of the component (B) is 25 mPa · s or less at 25 ° C., and is not particularly limited as long as it exceeds 0 mPa · s. From the viewpoints of improving thickness during application of a gel-like external skin preparation or skin cosmetic composition, and improving stickiness and stability over time, 0.5 to 20 mPa · s at 25 ° C. is preferable, and 1 to 20 mPa · s is more preferable, Even more preferred is 1.5 to 15 mPa · s.

Component (C): one or more selected from PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG-10 dimethicone, PEG-12 dimethicone

Component (C) in the present invention is a polyether-modified silicone, which is listed in "International Nomenclature of Cosmetic Ingredients" (INCI). PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG- 10 dimethicone, PEG-12 dimethicone. These can be used alone or in combination of two or more, but as the component (C) from the viewpoint of improving the thickness and stability over time during application of the external preparation for gel-like skin or skin cosmetic. And one or more selected from PEG-11 methyl ether dimethicone, PEG-9 dimethicone and PEG-10 dimethicone, and one or two types selected from PEG-11 methyl ether dimethicone and PEG-9 dimethicone The above is more preferable, and the combined use of PEG-11 methyl ether dimethicone and PEG-9 dimethicone is even more preferable. When it does not contain component (C) and contains only a polyether modified silicone other than PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG-10 dimethicone and PEG-12 dimethicone The stability over time may not be kept well, the squeaky feeling may be strong, and the usability may not be excellent.

The content of the component (C) is not particularly limited, but is preferably 0.01 to 5%, and more preferably 0.1 to 4%, from the viewpoint of improving the stickiness and external stability of the gel external skin preparation or the skin cosmetic. Is more preferable, and 1 to 4% is more preferable.

Although a component (C) will not be specifically limited if it is used for normal skin cosmetics, As a specific example, "SH3771M (PEG-12 dimethicone)", "SS-2801 (PEG-10 methyl ether) Dimethicone), "SS-2802 (PEG-10 methyl ether dimethicone)", "SS-2804 (PEG-12 dimethicone)" (above, Toray Dow Corning Co., Ltd.), "KF-6013" (PEG-9 dimethicone) And “KF-6017 (PEG-9 dimethicone)” (above, manufactured by Shin-Etsu Chemical Co., Ltd.) can be exemplified and can be used in the present invention.

Component (D): Carboxymethylcellulose Component (D) in the present invention is carboxymethylcellulose, which is one of cellulosic polymers. Moreover, as carboxymethylcellulose, when it contains a salt, the salt is not particularly limited. Examples of carboxymethylcellulose salts include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as ammonium, triethanolamine and triethylamine, and basic amino acids such as lysine and arginine. It can illustrate preferably.

The content of the component (D) is not particularly limited, but is preferably 0.01 to 1%, from the viewpoint of improving the thickness during application of the external preparation for gel-like skin preparation or skin cosmetic and improving the temporal stability. -0.1% is more preferable, and 0.03-0.08% is still more preferable.

Although component (D) can be used without particular limitation as long as it is used for ordinary skin cosmetics, as a specific example, "CMC die cell 1170", "CMC die cell 1180", "CMC The die cell 1270 "," CMC die cell 1280 "," CMC die cell 1290 "," CMC die cell 1350 "," CMC die cell 1380 "(all manufactured by Daicel Chemical Industries, Ltd.), etc. may be mentioned.

Component (E): Water The water of component (E) used in the present invention is not particularly limited as long as it is generally used in cosmetics. In addition to water, purified water, hot spring water, deep water, or steam distilled water of plants may be used, and one kind or two or more kinds can be appropriately selected and used as needed. Moreover, content is not specifically limited, According to the amount of other components suitably, it can contain, 20 to 90% is preferable.

The component (B) used in the present invention is a component to be blended in anticipation of the improvement of the characteristic sticky feeling of the component (A), but the component (C) is a component which in some cases enhances the stickiness of the preparation. is there. Unexpectedly, when the contained mass ratio (B) / (C) is 1 to 5, stability over time is improved, and further, the stickiness peculiar to the component (A) is improved. Furthermore, the content mass ratio (B) / (C) is preferably 2 to 4 from the viewpoint of the temporal stability improvement and the sticky feeling improvement. On the other hand, when the gel-like external skin preparation or skin cosmetic composition is applied to the skin at a content mass ratio (B) / (C) of less than 1, the thickness during application may not be excellent and the stickiness may be strong. . When the content mass ratio (B) / (C) exceeds 5, the thickness during application is not excellent, the stability over time is poor, and the stickiness may be strong.

The component (A) in the present invention is a polar molecule, but depending on the type and amount of polar molecule, it may interact with the component (D) to significantly reduce the viscosity and reduce the thickness during coating. Although the content mass ratio (A) / (D) of a component (A) and a component (D) is not specifically limited, 20-180 are preferable in the viewpoint which the thickness in application | coating becomes remarkably favorable, and 30-160 are preferable. More preferably, 40 to 140 are particularly preferred.

Furthermore, the component (A) in the present invention has a peculiar sticky feeling, the sticky feeling is strong, and the component (C) is also a component having a strong sticky feeling in some cases. Although the content mass ratio (A) / (C) of the component (A) and the component (C) is not particularly limited, the content mass ratio (A) / (C) is 1 to 4 in that the stickiness feeling is improved. 12 is preferable, 2-9 are preferable, and 2.5-8.75 are more preferable.

  The external preparation for gel-like skin or the cosmetic for skin according to the present invention is not particularly limited with respect to the form such as an emulsifying type, a solubilizing type, and a dissolving type. It is important that the components (A) to (E) are contained and that the content mass ratio (B) / (C) is 1 to 5. An emulsion gel-like external preparation for skin or a skin cosmetic is preferred in that the content of the component (B) is increased in order to improve the thickness during application and further improve the sticky feeling. Among them, oil-in-water is preferable. More preferred is a gel-like external preparation for skin or a skin cosmetic.

  In the gel-like external skin preparation or skin cosmetic composition of the present invention, in addition to the components (A) to (E), optional components contained in ordinary cosmetics as long as the effects of the present invention are not impaired, ie, components Lower alcohols other than (A) to (E), water-based components, oil-based components, powders, water-soluble polymers, film-forming agents, surfactants, oil-soluble gelling agents, organically modified clay minerals, resins, colorants UV absorbers, preservatives, antibacterial agents, perfumes, antioxidants, pH adjusters, chelating agents, cosmetic ingredients and the like can be contained.

  The "gel-like" of the gel-like external skin preparation or the cosmetic for skin according to the present invention means a state in which viscosity is imparted, and specifically, a cosmetic material standard / viscosity measurement method using a Brookfield viscometer The viscosity at 20 ° C. measured according to the second method is in the range of 1,000 to 100,000 mPa · s. From the viewpoint of thickness during coating and stability over time, it is preferably 3,000 mPa · s or more, more preferably 5,000 mPa · s or more, and preferably 80,000 mPa · s or less, 50,000 mPa · s. The following are more preferable. As a specific range, 3,000 to 80,000 mPa · s is preferable, and more preferably 5,000 to 50,000 mPa · s. If it is these viscosity ranges, it is excellent in the thickness in application | coating, there is no dripping, and it is excellent also in aging stability. If the viscosity at 20 ° C. is less than 1,000 mPa · s, the thickness during application may be poor and the stability over time may not be excellent. When the viscosity at 20 ° C. exceeds 100,000 mPa · s, the thickness during coating may be poor and the stickiness may be strong.

  The method for producing the external preparation for gel-like skin or the cosmetic for skin according to the present invention can be produced using any known method, regardless of emulsification or solubilization, without particular limitation. In order to improve the stickiness, it is preferable to use an emulsification method in that the content of the component (B) is increased. Among them, specifically, a dispersion emulsification method, a phase inversion emulsification method, a phase inversion temperature emulsification. Law etc. are mentioned. The components (B), (C) and other oil-based components are heated and mixed if a preferable method of production is exemplified in that a gel-like skin external preparation or a skin cosmetic having excellent emulsion stability over time is obtained. Emulsification is carried out by adding and mixing the heated component (E) later, and thereafter, there is a manufacturing method in which the components (A), (D), and optionally, other aqueous components are added and mixed. .

  The gel-like skin external preparation or skin cosmetic preparation of the present invention can be used as a skin external preparation. For example, external solutions, external gels, creams, ointments, liniments, lotions, lotions, plasters, sprays, aerosols and the like can be mentioned. As the method of use, a method of using with a hand, a finger, cotton, a method of impregnating with a non-woven fabric and the like, and the like can be mentioned.

  The gel-like skin external preparation or skin cosmetic of the present invention can be used as a skin cosmetic. For example, there can be exemplified lotion, milk, cream, cosmetic solution, massage, pack, hand cream, body lotion, body cream, sunscreen, foundation, eye shadow, eye liner, concealer and the like. As the method of use, a method of using with a hand, a finger, cotton, a method of impregnating with a non-woven fabric and the like, and the like can be mentioned.

Among the uses, it is preferable to use the product of the present invention as a massage agent because it is excellent in thickness during coating and lack of stickiness. By using it as a massage agent, other effects such as blood circulation promotion can be expected, and further improvement in skin firmness and elasticity can also be expected.

The gel-like skin external preparation or skin cosmetic of the present invention is preferably used as a pre-treatment skin external preparation or skin cosmetic. In the present invention, the pre-treatment skin external preparation or skin cosmetic refers to the first agent used first and the second agent used second when applying two external skin preparations or skin cosmetic preparations. Defined as the first agent. The external preparation for skin or the cosmetic for skin of the second agent is not particularly limited, and the external preparation for skin for various uses and the cosmetic for skin can be used. For example, external skin preparations include external liquid preparations, external gel preparations, creams, ointments, liniments, lotions, happs, plasters, sprays, aerosols and the like, and skin cosmetics include cosmetics. Water, milky lotion, cream, beauty essence, massage, pack, hand cream, body lotion, body cream, sunscreen, foundation, eye shadow, eye liner, concealer, etc. can be exemplified. Among them, the content of the oil component of the second agent is preferably 5% or less from the viewpoint of improving the stickiness after application of the second agent to the skin, and specifically, the preferred use is the skin As the external preparation, external solution, external gel, lotion and the like can be mentioned, and as skin cosmetic, cosmetic solution, cosmetic solution, milky lotion, body lotion and the like can be mentioned. When used as a pre-treatment skin external preparation or a skin cosmetic, the presence or absence of massage use is not particularly limited, but it is preferable to use as a massage agent from the viewpoint of improving the feeling of penetration when the second agent is applied.

When the gel-like external skin preparation or the skin cosmetic composition of the present invention is used as a pretreatment external skin skin composition or a skin care composition, the amphipathic property in the second agent is improved in terms of improving the feeling of penetration when the second agent is applied. Preferably, a substance is contained. The amphiphilic substance in the present invention refers to a substance having a hydrophilic group and a hydrophobic group in molecular structure, and is not particularly limited. As the amphiphilic substance contained in the second agent, in particular, from the viewpoint of improving the stickiness after application of the second agent, a substance having a polyoxyethylene chain as a hydrophilic group is preferable, and further, at the time of application of the second agent Polysorbate 80 is more preferable from the viewpoint of improving the stickiness.
In addition, from the viewpoint of improving the feeling of penetration at the time of applying the second agent, the content ratio by mass (A) / (A) in the gel-like external skin preparation or the skin cosmetic agent as the first external preparation for skin treatment or skin cosmetic. C) is preferably 2.5 to 20/3.

  EXAMPLES The present invention will be described in more detail by way of examples, but the present invention is not limited thereto. The content is shown in% by mass relative to the system in which the component is contained, unless otherwise stated.

Examples 1 to 9 and Comparative Examples 1 to 12: Cosmetic Solution The cosmetic solutions of Examples 1 to 9 and Comparative Examples 1 to 12 are prepared, B: firmness and elasticity of skin, B: thickness during application, C : No stickiness, d: stability over time was evaluated by the following method. The formulations of the cosmetic solutions and the evaluation results are shown together in Tables 1 to 3.

(Production method)
A: Ingredients (1) and (10) to (12) are uniformly dissolved and mixed at 70 ° C.
B: Ingredients (2) to (9) are uniformly dissolved and mixed at 70 ° C.
C: Dissolve and mix components (13) and (14) uniformly.
D: Emulsification was carried out by adding and mixing B to A, and after cooling to 40 ° C., a cosmetic solution was obtained by adding and mixing C.

(Evaluation item)
B: Skin firmness / elasticity B: Thickness during application C: Non-stickiness D: Stability over time

(Evaluation method)
[About B, B, C (Sensory evaluation)]
Ten specialist panels were selected who were trained in sensory evaluation for women in their twenties and forties and who could be evaluated on a certain basis. For each sample, the panel feels when applied to the skin, feels firmness and elasticity of the skin, and non-stickiness is rated and rated on a scale of 5 in the following absolute evaluation, and the total score of all panel members for each sample From the above, the average value was calculated, and it was judged by the following four-step judgment standard.

(I: sense of firmness and elasticity of the skin)
Absolute evaluation criteria (score): (evaluation)
6 points: I feel that there is a feeling of firmness and elasticity of the skin 5 points: I feel that there is a feeling of firmness and elasticity of the skin 4 points: I feel that there is a feeling of firmness and elasticity of the skin 3 points: Normal 2 Point: I do not feel that there is a sense of firmness and elasticity of the skin 1 point: I do not feel that there is a sense of firmness and elasticity of the skin 4-step judgment criteria (judgement): (average score)
:: more than 4.5 points: very good ○: less than 3 points 4.5 points or less: good Δ: less than 1.5 points 3 points or less: somewhat defective ×: less than 1.5 points: defective

(B: thickness during application)
Absolute evaluation criteria (score): (evaluation)
5 points: no dripping, very good thickness feeling 4 points: no dripping, good thickness feeling 3 points: no dripping, thickness feeling 2 points: no dripping However, thickness hardly feels 1 point: There is no thickness, it drips. 4 grade criteria (decision): (average score of score)
:: 4 points or more: very good ○: 4 points or less exceeding 3 points: good 良好: 3 points or less exceeding 2 points: slightly defective ×: 2 points or less: defective

(Ha: no feeling of stickiness)
Absolute evaluation criteria (score): (evaluation)
5 points: no sticky feeling 4 points: almost no sticky feeling 3 points: slightly sticky feeling 2 points: sticky feeling 1 point: very sticky feeling 4 criteria (decision): (score of score Average score)
:: 4 points or more: very good ○: 4 points or less exceeding 3 points: good 良好: 3 points or less exceeding 2 points: slightly defective ×: 2 points or less: defective

(D: stability over time)
Each sample was stored in a thermostat at 50 ° C. for one month, the state within one month was visually confirmed, and determination was made according to the following determination criteria.
Four-step criterion (judgment): (state of appearance)
:: no change within 1 month: very good ○: no creaming observed within 3 weeks,
Creaming is observed within 1 month: Good :: No creaming is observed within 2 weeks,
Creaming is observed within 3 weeks: Slightly poor ×: Creaming is observed within 2 weeks: Defective

As is clear from the results of Tables 1 to 3, the cosmetic solutions of Examples 1 to 9 have a feeling of firmness and elasticity in the skin, thickness during application, and no stickiness as compared with those of Comparative Examples 1 to 12. The stability over time was excellent.
On the other hand, Comparative Example 1 which does not contain the component (B) was inferior in the thickness during coating and the absence of stickiness.
The comparative example 2 which does not contain a component (C) was not able to emulsify, the system was isolate | separating, and it was not in the state which can be used.
The comparative example 3 which does not contain a component (D) was inferior in the thickness during application | coating, the absence of a sticky feeling, and time-lapse | temporal stability.
Comparative Example 4 in which the contained mass ratio (B) / (C) exceeds 5, the feeling of firmness and elasticity of the skin, and the temporal stability were inferior.
Comparative Example 5 in which the content mass ratio (B) / (C) was less than 1 was inferior in thickness during coating and in the absence of a sticky feeling.
Comparative Example 6 which does not contain the component (B) and which contains only a silicone oil having a viscosity at 25 ° C. of more than 25 mPa · s was inferior in skin firmness, elasticity and temporal stability.
Comparative Example 7 containing sorbitan sesquioleate containing no component (C), Comparative Example 8 containing polyglyceryl-3 polydimethylsiloxyethyl dimethicone, and Comparative Example 9 containing PEG-9 polydimethylsiloxyethyl dimethicone , The thickness during application, the non-stickiness, and the stability over time were inferior.
The comparative example 10 which does not contain a component (D) and contains hydroxypropyl methylcellulose was inferior in the thickness in application | coating, and the absence of a sticky feeling.
Comparative Example 11 in which the content of the component (A) was less than 1% was inferior in skin firmness and elasticity, and stability over time.
In Comparative Example 12 in which the content of the component (A) exceeds 10%, the feeling of firmness and elasticity of the skin and the absence of the feeling of stickiness were inferior.

Use Examples 1 to 11: Use of First Agent (Pre-Treatment Cosmetic Liquid) and Second Agent In Use Examples 1 to 11, Examples 1, 4, 5, 7, 8 and Comparative Example 11 were used as the first agent (Pre-treatment An example of using as a cosmetic solution) and then using an external preparation for skin or a skin cosmetic as a second agent, showing the feeling of penetration at the time of application of the second agent, no stickiness after application of the second agent I made an evaluation. Formulation examples A to C of the second agent (skin lotion) are shown in Table 4, and Formulation examples D and E (emulsion) are shown in Table 5. Examples 1, 4, 5, 7, 8 and Comparative Example 11 as the first agent and Formulation Examples A to E and Example 1 when used as the second agent The combinations and the evaluation results evaluated by the following method are shown together in Table 6.

(Production method of formulation examples A to C of the second agent (skin lotion))
A: Ingredients (1) to (4) and (9) are uniformly dissolved and mixed at 25 ° C.
B: Components (5) to (8) and (10) are uniformly dissolved and mixed at 25 ° C.
C: A was added to and mixed with B to obtain a lotion.

(Production method of formulation example D, E of second agent (emulsion))
A: Ingredients (3) to (8) are uniformly dissolved and mixed at 70 ° C.
B: Ingredients (9) to (14) and (16) are uniformly dissolved and mixed at 70 ° C.
C: Emulsification was performed by adding and mixing A to B, and after cooling to 40 ° C., an emulsion was obtained by adding and mixing the components (1), (2) and (15).

(Evaluation item)
E: Permeability at the time of second agent application: No stickiness after second agent application

(Evaluation method)
[Ho, about (Sensory evaluation)]
Ten specialist panels were selected who were trained in sensory evaluation for women in their twenties and forties and who could be evaluated on a certain basis. The specialist panel feels when the first agent (1.0 g) is applied after applying the first agent (1.0 g) to the skin and letting the skin blend in for 30 seconds, and the second agent application The absence of the subsequent sticky feeling was evaluated in 5 levels in the following absolute evaluation and scored, and the average value was calculated from the total score of all the panels for each use example, and judged according to the following 4 levels criterion.

(E: Permeability when applying the second agent)
Absolute evaluation criteria (score): (evaluation)
5 points: A very high feeling of penetration is felt when the second agent is applied after the application of the first agent as compared with the case where the second agent alone is used. 4 points: compared with the case where the second agent alone is used, the first Feels high penetration when applying the second agent after application of the agent 3 point: slightly higher penetration feeling when applying the second agent after applying the first agent than when using the second agent alone I feel 2 points: I feel equivalent penetration feeling when applying the second agent after applying the first agent as compared with using the second agent alone 1 point: compared with using the second agent alone, the second When the second agent is applied after the application of one agent, the feeling of penetration is felt low when it is applied. 4 criteria (judgement): (average score)
:: 4 points or more: very good ○: 4 points or less exceeding 3 points: good 良好: 3 points or less exceeding 2 points: slightly defective ×: 2 points or less: defective

(F: No stickiness after application of the second agent)
Absolute evaluation criteria (score): (evaluation)
5 points: Compared with after using the second agent alone, after applying the first agent, after applying the second agent, feel sticky feeling very weak 4 points: compared with after using the second agent alone, the first After application of the second agent after application of the second agent feels a weak feeling of stickiness 3 points: Compared with after using the second agent alone, after applying the second agent after applying the second agent, slightly weak sticky feeling I feel 2 points: Compared with after using the second agent alone, after applying the second agent I feel the same stickiness after applying the first agent 1 point: compared with after using the second agent alone, the second After applying one agent, after applying the second agent, feel strongly sticky feeling 4-step criteria (judgement): (average score)
:: 4 points or more: very good ○: 4 points or less exceeding 3 points: good 良好: 3 points or less exceeding 2 points: slightly defective ×: 2 points or less: defective

As is clear from the results in Table 6, Use Examples 1 to 10 were superior to Use Example 11 in the feeling of penetration at the time of application of the second agent and the absence of stickiness after the application of the second agent.
In Use Examples 1, 6 and 7, Use Examples 1 and 7 are superior in the feeling of penetration at the time of application of the second agent and the absence of stickiness after the application of the second agent, Preferably, the agent contains an amphiphilic substance.
Further, in Use Examples 1 to 5, since Use Examples 1, 3 and 4 are more excellent in permeability at the time of application of the second agent, the content mass ratio (A) / (C) in the first agent Is particularly preferably 2.5 to 20/3.
Further, in Use Examples 1 and 7, Use Example 1 is superior to the feeling of penetration at the time of application of the second agent and the absence of stickiness after the application of the second agent, among Use Examples 8 and 9 In the second example, the second example contains an amphipathic substance containing a polyoxyethylene group, because Use Example 8 is superior in permeability at the time of application of the second agent, and non-stickiness after application of the second agent. It is preferable to contain. Furthermore, in Use Examples 1 and 8, it is more preferable that the second agent contains Polysorbate 80, since Use Example 1 is superior to no stickiness after application of the second agent.
Also, in Use Example 10 where Example 1 is applied as the first agent and Example 1 is applied again as the second agent, according to Use Example 11, the feeling of penetration at the time of application of the second agent, and stickiness after application of the second agent It was excellent for nothing.

Example 10: Oil-in-water emulsion cream (component) (%)
1. 1,3-Butylene glycol 12.0
2. Glycerin 5.0
3. Purified water remaining amount 4. Nicotinamide 6.0
5. Sodium ascorbate 0.5
6. Sodium metasilicate 0.05
7. Hydrogenated lecithin 0.5
8. Hydrogenated lysolecithin 0.5
9. PEG-11 methyl ether dimethicone (Note 4) 0.5
10. PEG-10 dimethicone (Note 5) 0.3
11. Dimethicone (20 mPa · s / 25 ° C) (Note 1) 3.0
12. Ceramide 2 0.1
13. Astaxanthin 0.1
14. Tocopherol 0.01
15. Setostearyl alcohol 2.0
16. Behenyl alcohol 1.0
17. Glycerin mono-stearate 1.0
18. Methyl parahydroxybenzoate 0.05
19. Carbomer 0.15
20. Carboxymethylcellulose 0.1
21. Sodium hydroxide 0.004
22. Fragrance 0.05

(Production method)
A: Ingredients (1) to (6) are uniformly dissolved and mixed at 70 ° C.
B: Ingredients (7) to (17) are uniformly dissolved and mixed at 80 ° C.
C: Add B to A and emulsify at 70 ° C.
After cooling D: C to 40 ° C., components (18) to (22) were added to obtain an oil-in-water emulsion cream.

  The oil-in-water cream of Example 10 was excellent in all of the feeling of firmness and elasticity of the skin, the thickness during application, the non-stickiness, and the temporal stability.

Example 11: Oil-in-water base
(Component) (%)
1.1 1,3-butylene glycol 7.0
2. Dipropylene glycol 5.0
3. Triethanolamine 0.4
4. Purified water remaining amount 5. Nicotinic acid amide 4.0
6. Squalane 0.4
7. Stearic acid 1.0
8. PEG-80 hydrogenated castor oil 0.2
9. Sesquiisosorbate sorbitan 0.1
10. PEG-9 Dimethicone 0.5
11. Dimethicone (6 mPa · s / 25 ° C) (Note 10) 2.0
12. Setostearyl alcohol 0.3
13. Behenyl alcohol 0.5
14. Methyl parahydroxybenzoate 0.02
15. Talc 0.4
16. Hydrous silica 0.1
17. Mica 1.3
18. Titanium oxide 6.0
19. Iron oxide 0.1
20. Acrylic acid / methacrylic acid alkyl copolymer (Note 11) 0.3
21. Carboxymethylcellulose 0.1
22. Sodium hydroxide 0.008
23. Glycine 0.01
24. Arginine 0.01
25. Fragrance 0.01
Note 10: KF-96A-6cs (made by Shin-Etsu Chemical Co., Ltd.)
Note 11: CARBOPOL 1382 (manufactured by LUBRIZOL ADVANCED MATERIALS)

(Production method)
A: Ingredients (1) to (5) are uniformly dissolved and mixed at 70 ° C.
B: Components (6) to (14) are uniformly dissolved and mixed at 80 ° C.
C: Add B to A and emulsify at 70 ° C.
After cooling D: C to 40 ° C., components (15) to (25) were added to obtain an oil-in-water base.

  The oil-in-water base of Example 11 was excellent in all of the feeling of firmness and elasticity of the skin, the thickness during application, the non-stickiness, and the temporal stability.

Example 12: Oil-in-water cosmetic liquid
(Component) (%)
1. 1,3-Butylene glycol 5.0
2. Glycerin 5.0
3. Purified water remaining amount 4. Nicotinamide 6.0
5. Isostearic acid 0.1
6. Polysorbate 80 0.1
7. PEG-12 Dimethicone (Note 12) 0.2
8. PEG-10 methyl ether dimethicone 0.16
9. Squalane 1.0
10. Methyl trimethicone (Note 13) 1.5
11. Linoleic acid 0.05
12. Ceramide 3 0.1
13. Tocopherol 0.01
14. Setostearyl alcohol 0.5
15. Oleyl alcohol 1.0
16. Methyl parahydroxybenzoate 0.01
17. Carbomer 0.15
18. (Acrylate Na / Acryloyldimethyltaurine Na) copolymer solution (Note 14)
0.1
19. Carboxymethylcellulose 0.07
20. Sodium hydroxide 0.05
21. Ethanol 5.0
22. Sodium hyaluronate 0.01
23. Hydrolyzed hyaluronic acid 0.01
24. Hydrolyzed collagen 0.01
25. Glycosyl Trehalose 0.1
26. Flavoring agent 0.1
Note 12: SS-2804 (made by Toray Dow Corning)
Note 13: TMF-1.5 (made by Shin-Etsu Chemical Co., Ltd.)
Note 14: SIMULGEL EG (SEPIC)

(Production method)
A: Ingredients (1) to (4) are uniformly dissolved and mixed at 70 ° C.
B: Components (5) to (13) are uniformly dissolved and mixed at 80 ° C.
C: Add B to A and emulsify at 70 ° C.
After cooling D: C to 40 ° C., components (14) to (26) were added to obtain an oil-in-water cosmetic liquid.

  The oil-in-water type cosmetic solution of Example 12 was excellent in all of the feeling of firmness and elasticity of the skin, the thickness during application, the non-stickiness, and the temporal stability.

Formulation example 2 of second agent: Emulsion (component) (%)
1. 1,3-Butylene glycol 5.0
2. Glycerin 5.0
3. Purified water remaining amount 4. Citric acid 0.1
5. Hydrogenated lecithin 0.1
6. Stearate PEG-40 0.2
7. Stearate PEG-55 0.15
8. Squalane 5.0
9. Vaseline 0.5
10. Ceramide 3 0.1
11. Tocopherol 0.01
12. Setostearyl alcohol 0.5
13. Oleyl alcohol 1.0
14. Hexa (hydroxystearic acid / stearic acid / rosin acid) dipentaerythrityl 3.0
15. Carbomer 0.15
16. (Acrylate Na / Acryloyldimethyltaurine Na) copolymer solution (Note 14)
0.1
17. Sodium hydroxide 0.05
18. Ethanol 5.0
19. Sodium hyaluronate 0.01
20. Hydrolyzed hyaluronic acid 0.01
21. Hydrolyzed collagen 0.01
22. Glycosyl Trehalose 0.1
23. PEG-8 0.1

(Production method)
A: Ingredients (1) to (4) are uniformly dissolved and mixed at 70 ° C.
B: Ingredients (5) to (14) are uniformly dissolved and mixed at 80 ° C.
C: Add B to A and emulsify at 70 ° C.
D: After components (15) to (23) were added to and mixed with C, the mixture was cooled to 40 ° C. to obtain an emulsion.

(how to use)
Example 12 (2.0 g) was applied to the skin as the first agent, and after 30 seconds of skin acclimation, Formulation Example F: Emulsion (3.0 g) was applied to the skin as the second agent.

The oil-in-water type cosmetic solution of Example 12 was a pre-treatment oil-in-water type cosmetic solution excellent in penetration feeling at the time of applying the second agent and no stickiness after applying the second agent.

Claims (4)

The following components (A) to (E):
(A) Nicotinic acid amide 1 to 10% by mass
(B) Silicone oil having a viscosity of 25 mPa · s or less at 25 ° C. (C) PEG-10 methyl ether dimethicone, PEG-11 methyl ether dimethicone, PEG-9 dimethicone, PEG-10 dimethicone, PEG-12 dimethicone Contains one or more (D) carboxymethylcellulose (E) water, and
Gel-like skin external preparation or skin cosmetics whose content mass ratio (B) / (C) of a component (B) and a component (C) is 1-5. The gel-like external skin preparation or skin cosmetic preparation according to claim 1, wherein the content ratio (A) / (D) of component (A) to component (D) is 20 to 180. The gel-like skin external preparation or skin cosmetic preparation according to claim 1 or 2, wherein a content mass ratio (A) / (C) of the component (A) to the component (C) is 1-12. The gel-like external skin preparation or skin cosmetic according to any one of claims 1 to 3, which is a pre-treatment skin external preparation or a skin cosmetic.