JP2018521992A5

JP2018521992A5 -

Info

Publication number: JP2018521992A5
Application number: JP2017565934A
Authority: JP
Filing date: 2016-06-17
Publication date: 2019-08-15

Description

本発明に係る方法の実施において有用な溶液の一例は、ラウリルグルコシド界面活性剤；界面活性作用も有する、消泡剤としてのジメチコン；細胞増殖を促進し、免疫系応答を増強し、吸収を促進し、治癒を促進し、かつ保湿剤または皮膚軟化剤として作用する、抗炎症特性のためのアロエベラ；フリーラジカルを捕捉する能力を含む、アロエと同様の性質のためのアラントイン；保湿剤または皮膚軟化剤として作用する、抗炎症特性のためのコカミドプロピルプロピルベタイン；アロエおよびアラントインと同様の特性ためのベータグルカン；アロエおよびアラントインと同様の多くの特性を有する、Ｃｉｔｒｉｃｉｄａｌ（登録商標）ブランドのグレープフルーツ抽出物；抗微生物応答も促進し、免疫系を増強する周知の吸収促進剤である、コロイド状銀；フリーラジカル捕捉剤として作用する能力の、保湿剤または皮膚軟化剤としての特性のためのビタミンＥ；ならびに保湿および皮膚軟化特性のためのグリセリンを含む。 An example of a solution useful in the practice of the method of the present invention is a lauryl glucoside surfactant; dimethicone as a defoamer that also has a surfactant activity; promotes cell proliferation, enhances immune system response, promotes absorption and, promote healing, and act as humectants or emollients, aloe vera for anti-inflammatory properties; humectants or skin; allantoin for including the ability to capture free radicals, similar properties to aloe Cocamidopropylpropyl betaine for anti-inflammatory properties acting as a softener; beta glucan for properties similar to aloe and allantoin; Citricidal® brand grapefruit with many properties similar to aloe and allantoin Extract; a well-known absorption enhancer that also promotes antimicrobial responses and enhances the immune system Colloidal silver; glycerin for and moisturizing and emollient properties; the ability to act as free radical scavengers, Vitamin E for properties as humectants or emollients.

消毒剤および抗微生物剤であって、約４．０〜６．０のｐＨを有し、抗炎症、消泡、細胞増殖促進、免疫系増強、抗微生物、皮膚への吸収、およびフリーラジカル捕捉の機能を含む、有望な溶液は、アロエ、ジメチコン、アラントイン、コカミドプロピルプロピルベタイン、グレープフルーツ由来のＣｉｔｒｉｃｉｄａｌ（登録商標）ブランドの第４級化合物を含む柑橘系抽出物、コロイド状銀およびビタミンＥの混合物；アロエ、ジメチコン、アラントインおよびコロイド状銀またはグレープフルーツ抽出物の混合物；ジメチコン、アラントイン、グレープフルーツ抽出物、コロイド状銀およびビタミンＥの混合物；アロエ、ジメチコン、コカミドプロピルベタイン、グレープフルーツ抽出物およびコロイド状銀の混合物；アロエ、ジメチコン、グレープフルーツ抽出物およびコロイド状銀の混合物；ならびにジメチコン、コカミドプロピルベタイン、コロイド状銀およびベータグルカンの混合物を含む。 Disinfectant and antimicrobial agent having a pH of about 4.0 to 6.0, anti-inflammatory, antifoaming, cell growth promotion, immune system enhancement, antimicrobial, skin absorption, and free radical scavenging Promising solutions containing the functions of Aloe, dimethicone, allantoin, cocamidopropylpropyl betaine, citrus extracts containing Citricidal® quaternary compounds from grapefruit, colloidal silver and vitamin E mixture; aloe, dimethicone, a mixture of allantoin and colloidal silver or grapefruit extract; dimethicone, allantoin, grapefruit extract, a mixture of colloidal silver and vitamin E; aloe, dimethicone, Kokamidopuropi behenate Tyne, grapefruit extract and colloidal silver Mixture of aloe, dimethi Including well dimethicone, Kokamidopuropi behenate tines, a mixture of colloidal silver and beta glucan; down, grapefruit extract and mixtures of colloidal silver.

本発明の実施において有用なスキンケアおよびクレンジング剤は、米国特許第６，３５８，５１６号明細書に記載されるように、以下の他の成分を含むことができる。
（ａ）少なくとも１種の界面活性剤。
（ｂ）少なくとも１種の抗炎症剤。
（ｃ）少なくとも１種の消泡剤。
（ｄ）少なくとも１種の細胞増殖促進剤。
（ｅ）少なくとも１種の即効性抗微生物剤であって、前記成分のそれぞれが、皮膚適合性であり、前記組成物の他の成分とは異なり、かつ少なくとも１種の異なる成分は、下記の群から選択される。
（ｆ）免疫系増強剤であって、少なくとも１種の免疫系増強剤が、アロエベラ、ベータグルカン、コロイド状銀またはアラントインである。
（ｇ）吸収促進剤であって、少なくとも１種の吸収促進剤が、ベータグルカン、アロエベラ、またはコロイド状銀である。
（ｈ）保湿剤および皮膚軟化剤であって、少なくとも１種の保湿剤または皮膚軟化剤が、アロエベラ、ビタミンＥまたはコカミドプロピルである。
（ｉ）フリーラジカル捕捉剤であって、少なくとも１種のフリーラジカル捕捉剤が、バイオフラボノイド、ポリフェノール化合物、グレープフルーツ由来の第４級化合物、ベータグルカン、アラントイン、ビタミンＥ、ピクノジェノールまたはブドウ種子抽出物である。
（ｊ）治癒促進剤であって、前記成分が、皮膚に適用されると、素早く空気乾燥して、１ステップの適用で、皮膚を、クレンジングし、治療的に調整し、および処置する、安定で、すすぎ不要の、放射線滅菌可能な組成物を形成するために選択され、少なくとも１種の治癒促進剤が、アロエベラ、アラントインまたはベータグルカンである。 Skin care and cleansing agents useful in the practice of the present invention can include the following other ingredients, as described in US Pat. No. 6,358,516.
(A) at least one surfactant.
(B) at least one anti-inflammatory agent.
(C) At least one antifoaming agent.
(D) At least one cell growth promoter.
(E) at least one immediate-acting antimicrobial agent, each of the components being skin compatible, different from the other components of the composition, and at least one different component comprising: Selected from the group.
(F) an immune system enhancer, at least one immune system enhancing agent is Aloe vera, beta-glucan, colloidal silver or allantoin.
(G) an absorption enhancer, at least one absorption enhancer, beta-glucan, aloe vera or colloidal silver.
(H) a moisturizer and emollient, at least one humectant or emollient is a aloe vera, vitamin E or cocamidopropyl.
(I) a free radical scavenger, wherein at least one free radical scavenger is a bioflavonoid, a polyphenol compound, a quaternary compound derived from grapefruit, beta glucan, allantoin, vitamin E, pycnogenol or grape seed extract is there.
(J) A healing promoter, wherein when the ingredient is applied to the skin, it quickly air drys, cleans, therapeutically adjusts and treats the skin in one step application in, is selected to form unwanted radiation sterilizable rinse composition, of at least one cure accelerator is a aloe vera, allantoin or beta-glucan.

Ｔｈｅｒａｗｏｒｘ（登録商標）ブランドの消毒クレンザーを含む、本発明の実施において使用するための消毒剤溶液は、コロロヘキサドリンおよびアルコールとは違って、顔、粘膜、道または会陰部および直腸領域に対する適用に制限はなく、必要であると思われる限り頻繁に使用し得る。この製剤は、本質的に、広スペクトラムの抗微生物活性、抗酵母特性および抗真菌特性を有する一方で、皮膚に栄養およびうるおいを与え、皮膚のマンテル(mantel)の自然なｐＨを維持し、皮膚から感染病原体を除菌する場合であってもバリア機能が保持されるように角質層を支援する。抗微生物活性の持続は、約３時間までであることが実証されている。臭気も感染の１つの指標であり、本発明に係る方法の実施により、ＣＡＵＴＩに関連する臭気が低減または除去されることに留意すべきである。細菌細胞死の様式は、結果的に細胞質の内容物が失われ、さらに皮膚または生組織に損傷がない、細胞膜の破壊であると考えられる。柑橘系の抗微生物安定剤、四級アンモニウムカチオンを有する双性イオン性界面活性剤およびコロイド状銀の３つの物質が寄与すると考えられる。製剤は、ビタミンＥ、アロエベラ、アラントイン、コロイド状銀およびベータグルカン１を含有し、グラム陰性およびグラム陽性の細菌に対して、９９．９％超の有効性であると言われている。
Disinfectant solutions for use in the practice of the present invention, including Therawax® brand disinfecting cleansers, unlike colorohexadrine and alcohol, are intended for application to the face, mucous membranes, tract or perineum and rectal areas. There is no limit and it can be used as often as it seems necessary. This formulation inherently has a broad spectrum of antimicrobial activity, anti-yeast and antifungal properties, while nourishing and moisturizing the skin, maintaining the natural pH of the skin mantel, The stratum corneum is supported so that the barrier function is maintained even when the pathogen is sterilized. The duration of antimicrobial activity has been demonstrated to be up to about 3 hours. It should be noted that odor is also an indicator of infection and that the implementation of the method according to the present invention reduces or eliminates the odor associated with CAUTI. The mode of bacterial cell death is thought to be the destruction of the cell membrane resulting in the loss of cytoplasmic content and no damage to the skin or living tissue. Three substances are thought to contribute: citrus antimicrobial stabilizers, zwitterionic surfactants with quaternary ammonium cations, and colloidal silver. Formulation, vitamin E, aloe vera, allantoin, contain colloidal silver and beta glucan 1, against gram-negative and gram-positive bacteria are said to be the effectiveness of greater than 99.9%.

Claims

A composition that is histocompatible, non-antibiotic, has antimicrobial properties, is acidic, and is stable to radiation, having at least 10 ^−２-2 Containing multiple active ingredients processed to a sterilization assurance level of continuously, with sufficient frequency to enhance blood flow, increase oxygen load, and accelerate the transport of metabolic waste products, skin, mucous membranes, In a composition applied topically to intact or damaged mammalian tissue selected from tract or muscle tissue, the composition comprises:
(A) at least one surfactant;
(B) at least one anti-inflammatory agent;
(C) at least one antifoaming agent;
(D) at least one cell growth promoter;
(E) at least one immediate-acting antimicrobial agent, each of the components being skin compatible, different from the other components of the composition, and the following components:
(F) at least one immune system enhancer, at least one immune system enhancer selected from the group consisting of aloe vera, beta glucan, colloidal silver, and allantoin;
(G) at least one absorption enhancer selected from the group consisting of beta glucan, aloe vera, and colloidal silver;
(H) at least one humectant or emollient, at least one humectant and emollient selected from the group consisting of aloe vera, vitamin E, and cocamidopropyl betaine;
(I) at least one free radical scavenger selected from the group consisting of bioflavonoids, polyphenol compounds, quaternary compounds from grapefruit, beta-glucan, allantoin, vitamin E, pycnogenol, and grape seed extract At least one free radical scavenger; and
(J) at least one healing promoter, at least one therapeutic promoter selected from the group consisting of aloe vera, allantoin, and beta glucan,
At least one different component selected from the group consisting of
A composition comprising:

The composition of claim 1, wherein the tissue to which the composition is applied comprises intact skin including mucous membranes; intact but damaged skin; disrupted skin; and associated skin tissue.

The mammalian tissue to which the composition is applied is selected from the group consisting of muscles, regions of the body covered by stratum corneum, mucous membranes, tracts, perineal tissues and transitional surfaces between the mucosa and stratum corneum; The composition of claim 1.

It is initially applied that the composition is applied continuously with sufficient frequency to enhance the blood flow, increase oxygen load, and accelerate the transport of metabolic waste products. 2. The composition of claim 1 further characterized by a series of cares comprising applying the composition to the tissue and selecting, implementing and adhering to a protocol for ongoing treatment.

5. The composition of claim 4, wherein the tissue comprises cracked skin, exfoliated skin, scaly skin, bulky skin or skin exhibiting warts or soft fibroma.

The composition of claim 1, wherein the composition has been treated to preserve activity by exposure to radiation.

The composition of claim 1, wherein the composition is stable against radiation exposed to 4-35 kGy of gamma radiation.

The composition is about 10 ^−２-2 -10 ^−８-8 The composition of claim 7 characterized by a sterility assurance level of

The composition is about 10 ^−６-6 9. A composition according to claim 8, characterized by a sterility assurance level.

The composition of claim 1, wherein the mammalian tissue is skin and is a composition that acidifies the skin at a relatively uniform pH of 4.0 to 6.0 from the stratum corneum to the granular layer.

The composition of claim 1, further comprising warming the composition to increase absorption into the tissue.

The composition of claim 1, wherein the composition is warmed to a temperature of about 100-125 ° F. prior to application.

Intact or damaged mammal selected from skin, mucous membrane, tract or muscle tissue continuously and frequently enough to enhance blood flow, increase oxygen load and accelerate transport of metabolic waste products 2. The composition of claim 1, wherein topically applying to animal tissue comprises applying the composition to relieve muscle tension and increase range of motion.

Applying the composition is a procedure for sterilization of a patient or health care worker or other individual at risk of infection by an infectious agent, the procedure applying the composition to the body And applying the composition to various body parts, head, neck and chest areas; each arm and corresponding axilla separately; perineum; each leg and leg separately A composition according to claim 1, characterized by being applied in the order of: back;

Applying the composition comprises wiping the head, neck and chest with a first wet type cloth; wiping one arm and its corresponding axilla with a second cloth; Wiping the side arm and its corresponding axilla with a third cloth; wiping the perineum with a fourth cloth; wiping each leg and foot separately with a fifth and sixth cloth 15. The composition of claim 14, characterized by: wiping the back with a seventh cloth; wiping the heel with an eighth cloth; and disposing of the eight cloths. .

15. The composition of claim 14, wherein the procedure further comprises wiping a nostril with the composition.

The application is performed with a wet type cloth having the composition, and the procedure comprises wiping the head, neck and chest with a first wet type cloth; one arm and its corresponding axilla Wiping with the second cloth; wiping the opposite arm and its corresponding axilla with the third cloth; wiping the perineum with the fourth cloth; Wiping the opposite leg and foot with a sixth cloth; wiping the back with a seventh cloth; wiping the buttocks with an eighth cloth; and 15. A composition according to claim 14, characterized by the step of disposing of eight fabrics.

The applying is a procedure for treating layer burns to reduce the risk of infection, the procedure dressing the burned tissue with the composition, and the dressing for long-term tissue The composition of claim 1, comprising: leaving in contact with, removing the dressing, reapplying a new dressing with the composition, and repeating the steps. object.

The application applies the composition to convulsed or bruised muscles or skin over muscles that are at risk of convulsions or bruising, and the composition is regularly, convulsed, bruised or these Prevent muscle contusion and convulsions by continuously reapplying for a period of time during which there is a risk of, and for a period of time sufficient to establish a substantial reduction in the likelihood of subsequent recurrence of convulsions or contusions The composition of claim 1, which is a procedure for relaxation.

The composition of claim 1, wherein applying the composition comprises repeating the application immediately after an incontinence episode every few minutes to every 2-12 hours .

The composition according to claim 1, wherein the composition is applied as a foam, spray, liquid, gel or cream onto a wet type fabric having the composition.

The composition has the following properties: surfactant properties, antimicrobial properties, anti-inflammatory properties, cell growth promoting properties, immune system enhancing properties, free radical scavenging properties, and moisturizing or emollient properties, water, 2. The composition of claim 1, comprising a plurality of components having one or more of the properties.

The composition of claim 1, wherein the composition is dried without rinsing after each application.

The method comprises: applying the composition to a hand; applying the composition to the perineum and tract; and collecting a urine sample to reduce the risk of contamination of a urine sample. A composition according to 1.

The composition of claim 1 comprising applying the composition to a T-zone and wiping the nostrils.

The composition of claim 1, wherein the composition has been treated to preserve the activity of an active ingredient.