|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
|
US4554101A
(en)
|
1981-01-09 |
1985-11-19 |
New York Blood Center, Inc. |
Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
|
|
US5023243A
(en)
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
|
US4476301A
(en)
|
1982-04-29 |
1984-10-09 |
Centre National De La Recherche Scientifique |
Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
|
|
JPS5927900A
(ja)
|
1982-08-09 |
1984-02-14 |
Wakunaga Seiyaku Kk |
固定化オリゴヌクレオチド
|
|
US4501729A
(en)
|
1982-12-13 |
1985-02-26 |
Research Corporation |
Aerosolized amiloride treatment of retained pulmonary secretions
|
|
FR2540122B1
(fr)
|
1983-01-27 |
1985-11-29 |
Centre Nat Rech Scient |
Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
|
|
US4605735A
(en)
|
1983-02-14 |
1986-08-12 |
Wakunaga Seiyaku Kabushiki Kaisha |
Oligonucleotide derivatives
|
|
US4948882A
(en)
|
1983-02-22 |
1990-08-14 |
Syngene, Inc. |
Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
|
|
US4824941A
(en)
|
1983-03-10 |
1989-04-25 |
Julian Gordon |
Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
|
|
US4587044A
(en)
|
1983-09-01 |
1986-05-06 |
The Johns Hopkins University |
Linkage of proteins to nucleic acids
|
|
US5118802A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
|
|
US5550111A
(en)
|
1984-07-11 |
1996-08-27 |
Temple University-Of The Commonwealth System Of Higher Education |
Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
|
|
US5430136A
(en)
|
1984-10-16 |
1995-07-04 |
Chiron Corporation |
Oligonucleotides having selectably cleavable and/or abasic sites
|
|
US5367066A
(en)
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
|
US5258506A
(en)
|
1984-10-16 |
1993-11-02 |
Chiron Corporation |
Photolabile reagents for incorporation into oligonucleotide chains
|
|
US4828979A
(en)
|
1984-11-08 |
1989-05-09 |
Life Technologies, Inc. |
Nucleotide analogs for nucleic acid labeling and detection
|
|
FR2575751B1
(fr)
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
|
US5235033A
(en)
|
1985-03-15 |
1993-08-10 |
Anti-Gene Development Group |
Alpha-morpholino ribonucleoside derivatives and polymers thereof
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5405938A
(en)
|
1989-12-20 |
1995-04-11 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
|
US4762779A
(en)
|
1985-06-13 |
1988-08-09 |
Amgen Inc. |
Compositions and methods for functionalizing nucleic acids
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
US5317098A
(en)
|
1986-03-17 |
1994-05-31 |
Hiroaki Shizuya |
Non-radioisotope tagging of fragments
|
|
JPS638396A
(ja)
|
1986-06-30 |
1988-01-14 |
Wakunaga Pharmaceut Co Ltd |
ポリ標識化オリゴヌクレオチド誘導体
|
|
EP0260032B1
(en)
|
1986-09-08 |
1994-01-26 |
Ajinomoto Co., Inc. |
Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
|
|
US5219740A
(en)
|
1987-02-13 |
1993-06-15 |
Fred Hutchinson Cancer Research Center |
Retroviral gene transfer into diploid fibroblasts for gene therapy
|
|
US5276019A
(en)
|
1987-03-25 |
1994-01-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US5264423A
(en)
|
1987-03-25 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US4904582A
(en)
|
1987-06-11 |
1990-02-27 |
Synthetic Genetics |
Novel amphiphilic nucleic acid conjugates
|
|
EP0366685B1
(en)
|
1987-06-24 |
1994-10-19 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Nucleoside derivatives
|
|
US5585481A
(en)
|
1987-09-21 |
1996-12-17 |
Gen-Probe Incorporated |
Linking reagents for nucleotide probes
|
|
US4924624A
(en)
|
1987-10-22 |
1990-05-15 |
Temple University-Of The Commonwealth System Of Higher Education |
2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
|
|
US5188897A
(en)
|
1987-10-22 |
1993-02-23 |
Temple University Of The Commonwealth System Of Higher Education |
Encapsulated 2',5'-phosphorothioate oligoadenylates
|
|
US5525465A
(en)
|
1987-10-28 |
1996-06-11 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Oligonucleotide-polyamide conjugates and methods of production and applications of the same
|
|
DE3738460A1
(de)
|
1987-11-12 |
1989-05-24 |
Max Planck Gesellschaft |
Modifizierte oligonukleotide
|
|
JP3019994B2
(ja)
|
1987-11-30 |
2000-03-15 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
新規なオリゴデオキシヌクレオチド、それを使用した標的遺伝子の発現をブロックする方法、及び新規なオリゴデオキシヌクレオチド並びにそれを使用した標的遺伝子の発現を阻止する方法
|
|
US5403711A
(en)
|
1987-11-30 |
1995-04-04 |
University Of Iowa Research Foundation |
Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
|
|
US5082830A
(en)
|
1988-02-26 |
1992-01-21 |
Enzo Biochem, Inc. |
End labeled nucleotide probe
|
|
WO1989009221A1
(en)
|
1988-03-25 |
1989-10-05 |
University Of Virginia Alumni Patents Foundation |
Oligonucleotide n-alkylphosphoramidates
|
|
US5278302A
(en)
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
|
US5109124A
(en)
|
1988-06-01 |
1992-04-28 |
Biogen, Inc. |
Nucleic acid probe linked to a label having a terminal cysteine
|
|
US5216141A
(en)
|
1988-06-06 |
1993-06-01 |
Benner Steven A |
Oligonucleotide analogs containing sulfur linkages
|
|
US5175273A
(en)
|
1988-07-01 |
1992-12-29 |
Genentech, Inc. |
Nucleic acid intercalating agents
|
|
US5262536A
(en)
|
1988-09-15 |
1993-11-16 |
E. I. Du Pont De Nemours And Company |
Reagents for the preparation of 5'-tagged oligonucleotides
|
|
US5512439A
(en)
|
1988-11-21 |
1996-04-30 |
Dynal As |
Oligonucleotide-linked magnetic particles and uses thereof
|
|
US5599923A
(en)
|
1989-03-06 |
1997-02-04 |
Board Of Regents, University Of Tx |
Texaphyrin metal complexes having improved functionalization
|
|
US5457183A
(en)
|
1989-03-06 |
1995-10-10 |
Board Of Regents, The University Of Texas System |
Hydroxylated texaphyrins
|
|
US5391723A
(en)
|
1989-05-31 |
1995-02-21 |
Neorx Corporation |
Oligonucleotide conjugates
|
|
US5256775A
(en)
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
|
US4958013A
(en)
|
1989-06-06 |
1990-09-18 |
Northwestern University |
Cholesteryl modified oligonucleotides
|
|
US5451463A
(en)
|
1989-08-28 |
1995-09-19 |
Clontech Laboratories, Inc. |
Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
|
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
|
US5436146A
(en)
|
1989-09-07 |
1995-07-25 |
The Trustees Of Princeton University |
Helper-free stocks of recombinant adeno-associated virus vectors
|
|
US5254469A
(en)
|
1989-09-12 |
1993-10-19 |
Eastman Kodak Company |
Oligonucleotide-enzyme conjugate that can be used as a probe in hybridization assays and polymerase chain reaction procedures
|
|
US5399676A
(en)
|
1989-10-23 |
1995-03-21 |
Gilead Sciences |
Oligonucleotides with inverted polarity
|
|
US5264564A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences |
Oligonucleotide analogs with novel linkages
|
|
US5264562A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences, Inc. |
Oligonucleotide analogs with novel linkages
|
|
US5292873A
(en)
|
1989-11-29 |
1994-03-08 |
The Research Foundation Of State University Of New York |
Nucleic acids labeled with naphthoquinone probe
|
|
US5177198A
(en)
|
1989-11-30 |
1993-01-05 |
University Of N.C. At Chapel Hill |
Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
|
|
US5130302A
(en)
|
1989-12-20 |
1992-07-14 |
Boron Bilogicals, Inc. |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
|
|
US5486603A
(en)
|
1990-01-08 |
1996-01-23 |
Gilead Sciences, Inc. |
Oligonucleotide having enhanced binding affinity
|
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US5623065A
(en)
|
1990-08-13 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
|
US5578718A
(en)
|
1990-01-11 |
1996-11-26 |
Isis Pharmaceuticals, Inc. |
Thiol-derivatized nucleosides
|
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US5587470A
(en)
|
1990-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
|
US5149797A
(en)
|
1990-02-15 |
1992-09-22 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of rna and production of encoded polypeptides
|
|
US5220007A
(en)
|
1990-02-15 |
1993-06-15 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of RNA and production of encoded polypeptides
|
|
AU7579991A
(en)
|
1990-02-20 |
1991-09-18 |
Gilead Sciences, Inc. |
Pseudonucleosides and pseudonucleotides and their polymers
|
|
US5214136A
(en)
|
1990-02-20 |
1993-05-25 |
Gilead Sciences, Inc. |
Anthraquinone-derivatives oligonucleotides
|
|
US5321131A
(en)
|
1990-03-08 |
1994-06-14 |
Hybridon, Inc. |
Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
|
|
US5470967A
(en)
|
1990-04-10 |
1995-11-28 |
The Dupont Merck Pharmaceutical Company |
Oligonucleotide analogs with sulfamate linkages
|
|
EP0745689A3
(en)
|
1990-05-11 |
1996-12-11 |
Microprobe Corporation |
A dipstick for a nucleic acid hybridization assay
|
|
GB9011454D0
(en)
|
1990-05-22 |
1990-07-11 |
Medical Res Council |
Polynucleotide amplification
|
|
JPH06500688A
(ja)
|
1990-06-29 |
1994-01-27 |
ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン |
神経線維腫遺伝子
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
US5218105A
(en)
|
1990-07-27 |
1993-06-08 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5688941A
(en)
|
1990-07-27 |
1997-11-18 |
Isis Pharmaceuticals, Inc. |
Methods of making conjugated 4' desmethyl nucleoside analog compounds
|
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
|
ATE154246T1
(de)
|
1990-07-27 |
1997-06-15 |
Isis Pharmaceuticals Inc |
Nuklease resistente, pyrimidin modifizierte oligonukleotide, die die gen-expression detektieren und modulieren
|
|
PT98562B
(pt)
|
1990-08-03 |
1999-01-29 |
Sanofi Sa |
Processo para a preparacao de composicoes que compreendem sequencias de nucleo-sidos com cerca de 6 a cerca de 200 bases resistentes a nucleases
|
|
US5245022A
(en)
|
1990-08-03 |
1993-09-14 |
Sterling Drug, Inc. |
Exonuclease resistant terminally substituted oligonucleotides
|
|
US5177196A
(en)
|
1990-08-16 |
1993-01-05 |
Microprobe Corporation |
Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
|
|
US5512667A
(en)
|
1990-08-28 |
1996-04-30 |
Reed; Michael W. |
Trifunctional intermediates for preparing 3'-tailed oligonucleotides
|
|
US5214134A
(en)
|
1990-09-12 |
1993-05-25 |
Sterling Winthrop Inc. |
Process of linking nucleosides with a siloxane bridge
|
|
US5561225A
(en)
|
1990-09-19 |
1996-10-01 |
Southern Research Institute |
Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
|
|
WO1992005186A1
(en)
|
1990-09-20 |
1992-04-02 |
Gilead Sciences |
Modified internucleoside linkages
|
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
|
ATE198598T1
(de)
|
1990-11-08 |
2001-01-15 |
Hybridon Inc |
Verbindung von mehrfachreportergruppen auf synthetischen oligonukleotiden
|
|
US5510473A
(en)
|
1990-11-09 |
1996-04-23 |
The United States Of American As Represented By The Secretary Of Health And Human Services |
Cloning of the recA gene from thermus aquaticus YT-1
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5371241A
(en)
|
1991-07-19 |
1994-12-06 |
Pharmacia P-L Biochemicals Inc. |
Fluorescein labelled phosphoramidites
|
|
US5571799A
(en)
|
1991-08-12 |
1996-11-05 |
Basco, Ltd. |
(2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
|
|
CA2122030C
(en)
|
1991-10-24 |
1997-03-04 |
Muthiah Manoharan |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
|
US5700922A
(en)
|
1991-12-24 |
1997-12-23 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
|
US5595726A
(en)
|
1992-01-21 |
1997-01-21 |
Pharmacyclics, Inc. |
Chromophore probe for detection of nucleic acid
|
|
US5565552A
(en)
|
1992-01-21 |
1996-10-15 |
Pharmacyclics, Inc. |
Method of expanded porphyrin-oligonucleotide conjugate synthesis
|
|
GB9206016D0
(en)
|
1992-03-19 |
1992-04-29 |
Sandoz Ltd |
Improvements in or relating to organic compounds
|
|
US5633360A
(en)
|
1992-04-14 |
1997-05-27 |
Gilead Sciences, Inc. |
Oligonucleotide analogs capable of passive cell membrane permeation
|
|
US5434257A
(en)
|
1992-06-01 |
1995-07-18 |
Gilead Sciences, Inc. |
Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
|
|
US6268213B1
(en)
|
1992-06-03 |
2001-07-31 |
Richard Jude Samulski |
Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy
|
|
WO1993025673A1
(en)
|
1992-06-04 |
1993-12-23 |
The Regents Of The University Of California |
In vivo gene therapy with intron-free sequence of interest
|
|
US5272250A
(en)
|
1992-07-10 |
1993-12-21 |
Spielvogel Bernard F |
Boronated phosphoramidate compounds
|
|
US5652355A
(en)
|
1992-07-23 |
1997-07-29 |
Worcester Foundation For Experimental Biology |
Hybrid oligonucleotide phosphorothioates
|
|
US5869305A
(en)
|
1992-12-04 |
1999-02-09 |
The University Of Pittsburgh |
Recombinant viral vector system
|
|
US5478745A
(en)
|
1992-12-04 |
1995-12-26 |
University Of Pittsburgh |
Recombinant viral vector system
|
|
US5574142A
(en)
|
1992-12-15 |
1996-11-12 |
Microprobe Corporation |
Peptide linkers for improved oligonucleotide delivery
|
|
US5593972A
(en)
|
1993-01-26 |
1997-01-14 |
The Wistar Institute |
Genetic immunization
|
|
NZ262582A
(en)
|
1993-01-26 |
1997-10-24 |
David B Weiner |
Compositions and methods for delivery of genetic material
|
|
US5476925A
(en)
|
1993-02-01 |
1995-12-19 |
Northwestern University |
Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
|
|
GB9304618D0
(en)
|
1993-03-06 |
1993-04-21 |
Ciba Geigy Ag |
Chemical compounds
|
|
EP0691977B1
(en)
|
1993-03-31 |
1997-11-26 |
Sanofi |
Oligonucleotides with amide linkages replacing phosphodiester linkages
|
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
|
EP0733059B1
(en)
|
1993-12-09 |
2000-09-13 |
Thomas Jefferson University |
Compounds and methods for site-directed mutations in eukaryotic cells
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
US5625050A
(en)
|
1994-03-31 |
1997-04-29 |
Amgen Inc. |
Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
|
|
US5658784A
(en)
*
|
1994-04-14 |
1997-08-19 |
Dana-Farber Cancer Institute, Inc. |
Nucleic acid encoding transcription factor p300 and uses of p300
|
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5597696A
(en)
|
1994-07-18 |
1997-01-28 |
Becton Dickinson And Company |
Covalent cyanine dye oligonucleotide conjugates
|
|
US5580731A
(en)
|
1994-08-25 |
1996-12-03 |
Chiron Corporation |
N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
|
|
US5962428A
(en)
|
1995-03-30 |
1999-10-05 |
Apollon, Inc. |
Compositions and methods for delivery of genetic material
|
|
US6093570A
(en)
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
|
US5741683A
(en)
|
1995-06-07 |
1998-04-21 |
The Research Foundation Of State University Of New York |
In vitro packaging of adeno-associated virus DNA
|
|
US5652356A
(en)
|
1995-08-17 |
1997-07-29 |
Hybridon, Inc. |
Inverted chimeric and hybrid oligonucleotides
|
|
DE19608753C1
(de)
|
1996-03-06 |
1997-06-26 |
Medigene Gmbh |
Transduktionssystem und seine Verwendung
|
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
DE69824859T2
(de)
|
1997-04-14 |
2005-08-04 |
Cell Genesys, Inc., Foster City |
Methoden zur erhöhung der effizienz rekombinanter aav produkte
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
GB9710807D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
|
CA2263784A1
(en)
|
1998-03-23 |
1999-09-23 |
Megabios Corporation |
Dual-tagged proteins and their uses
|
|
EP1080218A1
(en)
|
1998-05-27 |
2001-03-07 |
University of Florida |
Method of preparing recombinant adeno-associated virus compositions by using an iodixanol gradient
|
|
US6140081A
(en)
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
DE69941905D1
(de)
|
1998-11-10 |
2010-02-25 |
Univ North Carolina |
Virusvektoren und verfahren für ihre herstellung und verabreichung.
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US7084125B2
(en)
|
1999-03-18 |
2006-08-01 |
Exiqon A/S |
Xylo-LNA analogues
|
|
US6734291B2
(en)
|
1999-03-24 |
2004-05-11 |
Exiqon A/S |
Synthesis of [2.2.1]bicyclo nucleosides
|
|
NZ514348A
(en)
|
1999-05-04 |
2004-05-28 |
Exiqon As |
L-ribo-LNA analogues
|
|
US20040192593A1
(en)
|
1999-07-26 |
2004-09-30 |
Baylor College Of Medicine |
Protease resistant ti-growth hormone releasing hormone
|
|
DK1204739T3
(da)
|
1999-08-09 |
2008-10-20 |
Targeted Genetics Corp |
Forögelse af ekspression af en enkeltstrenget, heterolog nukleotidsekvens fra rekombinante, virale vektorer ved en sådan udformning af sekvensen at den danner intrastrengbasepar
|
|
US6287860B1
(en)
|
2000-01-20 |
2001-09-11 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of MEKK2 expression
|
|
US20020006397A1
(en)
|
2000-04-28 |
2002-01-17 |
Roberts Bruce L. |
In VIVO loading of MHC
|
|
AU2001253914B2
(en)
|
2000-04-28 |
2006-06-08 |
Sangamo Therapeutics, Inc. |
Targeted modification of chromatin structure
|
|
US7465583B2
(en)
|
2000-06-01 |
2008-12-16 |
The University Of North Carolina At Chapel Hill |
Duplexed parvovirus vectors
|
|
CA2410901C
(en)
|
2000-06-01 |
2012-03-20 |
University Of North Carolina At Chapel Hill |
Methods and compounds for controlled release of recombinant parvovirus vectors
|
|
JP2002060786A
(ja)
|
2000-08-23 |
2002-02-26 |
Kao Corp |
硬質表面用殺菌防汚剤
|
|
US7879540B1
(en)
|
2000-08-24 |
2011-02-01 |
Promega Corporation |
Synthetic nucleic acid molecule compositions and methods of preparation
|
|
JP2005500061A
(ja)
|
2001-08-20 |
2005-01-06 |
ザ スクリップス リサーチ インスティテュート |
Ｃｎｎについての亜鉛フィンガー結合ドメイン
|
|
WO2003020739A2
(en)
|
2001-09-04 |
2003-03-13 |
Exiqon A/S |
Novel lna compositions and uses thereof
|
|
KR101015854B1
(ko)
|
2001-11-13 |
2011-02-23 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
아데노-결합 바이러스 (ａａｖ) 서열을 검출 및/또는확인하는 방법 및 그 방법에 의해 확인된 신규한 서열을분리하는 방법
|
|
WO2003052051A2
(en)
|
2001-12-17 |
2003-06-26 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus (aav) serotype 8 sequences
|
|
WO2003072788A1
(en)
|
2002-02-21 |
2003-09-04 |
The Wistar Institute Of Anatomy And Biology |
Methods and compositions for reversibly controlling expression of target genes in cells
|
|
US7449561B1
(en)
|
2002-02-26 |
2008-11-11 |
City Of Hope |
Alterations in the dystrophin gene associated with sporadic dilated cardiomyopathy
|
|
US7074596B2
(en)
|
2002-03-25 |
2006-07-11 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Synthesis and use of anti-reverse mRNA cap analogues
|
|
US20070015238A1
(en)
|
2002-06-05 |
2007-01-18 |
Snyder Richard O |
Production of pseudotyped recombinant AAV virions
|
|
ATE485031T1
(de)
|
2002-06-28 |
2010-11-15 |
Protiva Biotherapeutics Inc |
Verfahren und vorrichtung zur herstellung von liposomen
|
|
AU2003295366B2
(en)
|
2002-11-04 |
2011-11-24 |
Advisys, Inc. |
Synthetic muscle promoters with activities exceeding naturally occurring regulatory sequences in cardiac cells
|
|
WO2005014815A1
(en)
|
2003-08-08 |
2005-02-17 |
President And Fellows Of Harvard College |
siRNA BASED METHODS FOR TREATING ALZHEIMER’S DISEASE
|
|
CA2539439C
(en)
|
2003-09-19 |
2012-10-23 |
Sangamo Biosciences, Inc. |
Engineered zinc finger proteins for regulation of gene expression
|
|
ES2648241T3
(es)
|
2003-09-30 |
2017-12-29 |
The Trustees Of The University Of Pennsylvania |
Clados de virus adenoasociados (AAV), secuencias, vectores que contienen el mismo, y usos de los mismos
|
|
US20070192880A1
(en)
|
2003-10-03 |
2007-08-16 |
University Of Rochester |
Horming response element binding transregulators
|
|
US8507277B2
(en)
|
2003-10-24 |
2013-08-13 |
Gencia Corporation |
Nonviral vectors for delivering polynucleotides
|
|
CA2569645C
(en)
|
2004-06-07 |
2014-10-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use
|
|
JP4796062B2
(ja)
|
2004-06-07 |
2011-10-19 |
プロチバ バイオセラピューティクス インコーポレイティッド |
脂質封入干渉ｒｎａ
|
|
SI1766010T1
(sl)
|
2004-06-28 |
2011-06-30 |
Univ Western Australia |
Protismiselni oligonukleotidi za induciranje preskakovanja eksonov in postopki za njihovo uporabo
|
|
US7728118B2
(en)
|
2004-09-17 |
2010-06-01 |
Promega Corporation |
Synthetic nucleic acid molecule compositions and methods of preparation
|
|
ES2525143T3
(es)
|
2005-04-07 |
2014-12-18 |
The Trustees Of The University Of Pennsylvania |
Cápsides de AAVrh.64 modificado, composiciones que las contienen y usos de las mismas
|
|
JP4495210B2
(ja)
|
2005-06-09 |
2010-06-30 |
パナソニック株式会社 |
振幅誤差補償装置及び直交度誤差補償装置
|
|
WO2007012191A1
(en)
|
2005-07-27 |
2007-02-01 |
Protiva Biotherapeutics, Inc. |
Systems and methods for manufacturing liposomes
|
|
CN101278041A
(zh)
|
2005-08-05 |
2008-10-01 |
密执安州大学 |
来自actinobacillus succinogenes130z（atcc 55618）用于从a.succinogenes c4－途径生产化学产品的基因
|
|
US7943374B2
(en)
|
2005-08-21 |
2011-05-17 |
Markus Hildinger |
Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb
|
|
RS63964B1
(sr)
|
2005-08-23 |
2023-03-31 |
Univ Pennsylvania |
Rnk koja sadrži modifikovane nukleozide i postupci za njenu upotrebu
|
|
WO2007120542A2
(en)
|
2006-03-30 |
2007-10-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Aav capsid library and aav capsid proteins
|
|
AU2007269048A1
(en)
|
2006-07-05 |
2008-01-10 |
The Scripps Research Institute |
Chimeric zinc finger recombinases optimized for catalysis by directed evolution
|
|
US20090018031A1
(en)
|
2006-12-07 |
2009-01-15 |
Switchgear Genomics |
Transcriptional regulatory elements of biological pathways tools, and methods
|
|
WO2008070859A2
(en)
|
2006-12-07 |
2008-06-12 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Treatment of skin conditions by dickkopf1 (dkk1)
|
|
WO2008086807A2
(en)
|
2007-01-19 |
2008-07-24 |
Exiqon A/S |
Mediated cellular delivery of lna oligonucleotides
|
|
US20100261175A1
(en)
|
2007-06-15 |
2010-10-14 |
Exiqon A/S |
Use of short oligonucleotides for reagent redundancy experiments in rna functional analysis
|
|
HUE028662T2
(en)
|
2007-10-26 |
2016-12-28 |
Academisch Ziekenhuis Leiden |
Preparations and methods for controlling muscle disorders
|
|
CN102083878B
(zh)
|
2008-05-13 |
2013-07-10 |
华盛顿大学 |
用于向细胞内递送的二嵌段共聚物和其多核苷酸复合物
|
|
US20100076057A1
(en)
|
2008-09-23 |
2010-03-25 |
Northwestern University |
TARGET DNA INTERFERENCE WITH crRNA
|
|
CN104119242B
(zh)
|
2008-10-09 |
2017-07-07 |
泰米拉制药公司 |
改善的氨基脂质和递送核酸的方法
|
|
BRPI0914440A8
(pt)
|
2008-10-17 |
2016-01-19 |
Joule Unlimited Inc |
Método para produção biogênica de etanol e cianobactéria geneticamente modificada
|
|
EP2762567B1
(en)
|
2008-10-24 |
2016-07-13 |
Sarepta Therapeutics, Inc. |
Multiple exon skipping compositions for DMD
|
|
KR20110095292A
(ko)
|
2008-11-06 |
2011-08-24 |
유니버시티 오브 워싱톤 |
다중블록 공중합체
|
|
CN104910025B
(zh)
|
2008-11-07 |
2019-07-16 |
麻省理工学院 |
氨基醇类脂质和其用途
|
|
WO2010075424A2
(en)
|
2008-12-22 |
2010-07-01 |
The Regents Of University Of California |
Compositions and methods for downregulating prokaryotic genes
|
|
EP2206723A1
(en)
|
2009-01-12 |
2010-07-14 |
Bonas, Ulla |
Modular DNA-binding domains
|
|
WO2010108126A2
(en)
|
2009-03-19 |
2010-09-23 |
Fate Therapeutics, Inc. |
Reprogramming compositions and methods of using the same
|
|
SMT202100696T1
(it)
|
2009-06-10 |
2022-01-10 |
Arbutus Biopharma Corp |
Formulazione lipidica migliorata
|
|
EP2281579A1
(en)
|
2009-08-05 |
2011-02-09 |
BioNTech AG |
Vaccine composition comprising 5'-Cap modified RNA
|
|
WO2011036640A2
(en)
|
2009-09-24 |
2011-03-31 |
Cellectis |
Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations
|
|
MX353245B
(es)
|
2009-10-31 |
2018-01-08 |
New World Laboratories Inc Star |
Metodos para reprogramar células y sus usos.
|
|
PT2816112T
(pt)
|
2009-12-10 |
2018-11-20 |
Univ Iowa State Res Found Inc |
Modificação do adn modificada pelo efector tal
|
|
EP2533629B1
(en)
|
2010-02-11 |
2018-11-28 |
Recombinetics, Inc. |
Methods and materials for producing transgenic artiodactyls
|
|
CN102869779A
(zh)
|
2010-03-29 |
2013-01-09 |
宾夕法尼亚大学托管会 |
药理学诱导的转基因消融系统
|
|
US9315825B2
(en)
|
2010-03-29 |
2016-04-19 |
The Trustees Of The University Of Pennsylvania |
Pharmacologically induced transgene ablation system
|
|
US20130145487A1
(en)
|
2010-05-12 |
2013-06-06 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof
|
|
KR101953237B1
(ko)
|
2010-05-17 |
2019-02-28 |
상가모 테라퓨틱스, 인코포레이티드 |
신규 dna 결합 단백질 및 이의 용도
|
|
IT1400425B1
(it)
|
2010-06-08 |
2013-05-31 |
Amsterdam Molecular Therapeutics Bv |
Modified snrnas for use in therapy.
|
|
EP2517731A1
(en)
|
2011-04-07 |
2012-10-31 |
Ludwig-Maximilians-Universität München |
Method of activating a target gene in a cell
|
|
US9181675B2
(en)
|
2011-05-12 |
2015-11-10 |
Hitachi Construction Machinery Co., Ltd. |
Construction machine
|
|
LT2717893T
(lt)
|
2011-06-08 |
2019-08-12 |
Translate Bio, Inc. |
Lipidų nanodalelių kompozicijos ir mrnr pristatymo būdai
|
|
WO2013009525A1
(en)
|
2011-07-08 |
2013-01-17 |
Cellectis S.A. |
Method for increasing the efficiency of double-strand break-induced mutagenssis
|
|
WO2013074999A1
(en)
|
2011-11-16 |
2013-05-23 |
Sangamo Biosciences, Inc. |
Modified dna-binding proteins and uses thereof
|
|
US8450107B1
(en)
|
2011-11-30 |
2013-05-28 |
The Broad Institute Inc. |
Nucleotide-specific recognition sequences for designer TAL effectors
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
CN112251436A
(zh)
|
2012-01-27 |
2021-01-22 |
比奥马林技术公司 |
治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
|
|
WO2013143555A1
(en)
|
2012-03-26 |
2013-10-03 |
Biontech Ag |
Rna formulation for immunotherapy
|
|
WO2013152220A2
(en)
|
2012-04-04 |
2013-10-10 |
Life Technologies Corporation |
Tal-effector assembly platform, customized services, kits and assays
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
US9738879B2
(en)
|
2012-04-27 |
2017-08-22 |
Duke University |
Genetic correction of mutated genes
|
|
SI3401400T1
(sl)
|
2012-05-25 |
2019-10-30 |
Univ California |
Postopki in sestavki za RNA usmerjeno modifikacijo tarčne DNA in za RNA usmerjeno modulacijo prepisovanja
|
|
US9890364B2
(en)
|
2012-05-29 |
2018-02-13 |
The General Hospital Corporation |
TAL-Tet1 fusion proteins and methods of use thereof
|
|
CA2873274C
(en)
|
2012-06-08 |
2021-06-01 |
Ethris Gmbh |
Pulmonary delivery of messenger rna
|
|
EP3808844A1
(en)
|
2012-07-25 |
2021-04-21 |
The Broad Institute, Inc. |
Inducible dna binding proteins and genome perturbation tools and applications thereof
|
|
WO2014025887A1
(en)
|
2012-08-07 |
2014-02-13 |
The General Hospital Corporation |
Selective reactivation of genes on the inactive x chromosome
|
|
EP3789405A1
(en)
|
2012-10-12 |
2021-03-10 |
The General Hospital Corporation |
Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
|
|
EP4357457B1
(en)
|
2012-10-23 |
2024-10-16 |
Toolgen Incorporated |
Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
|
|
BR122019025681B1
(pt)
|
2012-11-01 |
2023-04-18 |
Factor Bioscience Inc |
Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
|
|
US20140140969A1
(en)
|
2012-11-20 |
2014-05-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for muscular dystrophies
|
|
EP2928496B1
(en)
|
2012-12-06 |
2019-10-09 |
Sigma Aldrich Co. LLC |
Crispr-based genome modification and regulation
|
|
WO2014093479A1
(en)
|
2012-12-11 |
2014-06-19 |
Montana State University |
Crispr (clustered regularly interspaced short palindromic repeats) rna-guided control of gene regulation
|
|
CN114634950A
(zh)
|
2012-12-12 |
2022-06-17 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
ES2701749T3
(es)
|
2012-12-12 |
2019-02-25 |
Broad Inst Inc |
Métodos, modelos, sistemas y aparatos para identificar secuencias diana para enzimas Cas o sistemas CRISPR-Cas para secuencias diana y transmitir resultados de los mismos
|
|
WO2014093701A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
US20140242664A1
(en)
|
2012-12-12 |
2014-08-28 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions for sequence manipulation
|
|
SG10201912328UA
(en)
|
2012-12-12 |
2020-02-27 |
Broad Inst Inc |
Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
PL2931898T3
(pl)
|
2012-12-12 |
2016-09-30 |
Le Cong |
Projektowanie i optymalizacja systemów, sposoby i kompozycje do manipulacji sekwencją z domenami funkcjonalnymi
|
|
KR20150095861A
(ko)
|
2012-12-17 |
2015-08-21 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
Rna-가이드된 인간 게놈 조작
|
|
AU2014232443B2
(en)
|
2013-03-15 |
2018-08-30 |
Edward J. Britt |
Energy conversion device and method for making and using same
|
|
BR112015022998A2
(pt)
|
2013-03-15 |
2017-11-14 |
Sarepta Therapeutics Inc |
composições melhoradas para o tratamento de distrofia muscular
|
|
US10760064B2
(en)
*
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
WO2014204578A1
(en)
*
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
IL289396B2
(en)
|
2013-03-15 |
2023-12-01 |
The General Hospital Coporation |
Using tru-grnas to increase the specificity of RNA-guided genome editing
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
WO2014172470A2
(en)
*
|
2013-04-16 |
2014-10-23 |
Whitehead Institute For Biomedical Research |
Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal
|
|
CN105683376A
(zh)
|
2013-05-15 |
2016-06-15 |
桑格摩生物科学股份有限公司 |
用于治疗遗传病状的方法和组合物
|
|
WO2014191128A1
(en)
|
2013-05-29 |
2014-12-04 |
Cellectis |
Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
|
|
EP3603679B1
(en)
|
2013-06-04 |
2022-08-10 |
President and Fellows of Harvard College |
Rna-guided transcriptional regulation
|
|
US9267135B2
(en)
|
2013-06-04 |
2016-02-23 |
President And Fellows Of Harvard College |
RNA-guided transcriptional regulation
|
|
AU2014274840B2
(en)
|
2013-06-05 |
2020-03-12 |
Duke University |
RNA-guided gene editing and gene regulation
|
|
DK3011031T3
(da)
|
2013-06-17 |
2020-12-21 |
Broad Inst Inc |
Fremføring og anvendelse af crispr-cas-systemerne, vektorer og sammensætninger til levermålretning og -terapi
|
|
EP3620524A1
(en)
|
2013-06-17 |
2020-03-11 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
|
|
EP3011035B1
(en)
|
2013-06-17 |
2020-05-13 |
The Broad Institute, Inc. |
Assay for quantitative evaluation of target site cleavage by one or more crispr-cas guide sequences
|
|
HUE056760T2
(hu)
|
2013-07-11 |
2022-03-28 |
Modernatx Inc |
A CRISPR-hez kapcsolódó fehérjéket és a szintetikus SGRNS-ket kódoló szintetikus polinukleotidokat tartalmazó készítmények és felhasználási módjaik
|
|
US10421957B2
(en)
|
2013-07-29 |
2019-09-24 |
Agilent Technologies, Inc. |
DNA assembly using an RNA-programmable nickase
|
|
CA2919828C
(en)
|
2013-07-30 |
2022-07-19 |
Phaserx, Inc. |
Block copolymers and their conjugates or complexes with oligonucleotides
|
|
WO2015021426A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
A crispr/cas system-based novel fusion protein and its application in genome editing
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
JPWO2015030149A1
(ja)
|
2013-08-29 |
2017-03-02 |
国立大学法人鳥取大学 |
細胞のアンチエイジングに関連する生体分子群
|
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
|
US10822606B2
(en)
|
2013-09-27 |
2020-11-03 |
The Regents Of The University Of California |
Optimized small guide RNAs and methods of use
|
|
JP2016536021A
(ja)
|
2013-11-07 |
2016-11-24 |
エディタス・メディシン，インコーポレイテッド |
ＣＲＩＳＰＲ関連方法および支配ｇＲＮＡのある組成物
|
|
KR20160089530A
(ko)
|
2013-12-12 |
2016-07-27 |
더 브로드 인스티튜트, 인코퍼레이티드 |
Ｈｂｖ 및 바이러스 질병 및 질환을 위한 ｃｒｉｓｐｒｃａｓ 시스템 및 조성물의 전달，용도 및 치료적 적용
|
|
EP3080258A1
(en)
|
2013-12-12 |
2016-10-19 |
The Broad Institute, Inc. |
Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
|
|
DK3079725T3
(da)
|
2013-12-12 |
2020-01-20 |
Broad Inst Inc |
Administration, brug og terapeutiske anvendelser af crispr-cas-systemerne og sammensætninger til genomredigering
|
|
BR112016013213A2
(pt)
|
2013-12-12 |
2017-12-05 |
Massachusetts Inst Technology |
administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas
|
|
KR20160097327A
(ko)
|
2013-12-12 |
2016-08-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
유전자 산물, 구조 정보 및 유도성 모듈형 ｃａｓ 효소의 발현의 변경을 위한 ｃｒｉｓｐｒ-ｃａｓ 시스템 및 방법
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
|
|
US20150166985A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting von willebrand factor point mutations
|
|
JP2017509322A
(ja)
|
2014-01-29 |
2017-04-06 |
ヘルムホルツ ツェントゥルム ミュンヘン ドイチェス フォルシュングスツェントゥルム フューア ゲズントハイト ウント ウムヴェルト （ゲーエムベーハー） |
分化細胞の分化転換
|
|
US10286084B2
(en)
|
2014-02-18 |
2019-05-14 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
|
EP3553176A1
(en)
|
2014-03-10 |
2019-10-16 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
|
|
CA2944978C
(en)
|
2014-04-08 |
2024-02-13 |
North Carolina State University |
Methods and compositions for rna-directed repression of transcription using crispr-associated genes
|
|
KR102595473B1
(ko)
|
2014-04-18 |
2023-10-30 |
에디타스 메디신, 인코포레이티드 |
암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분
|
|
SG10202002486QA
(en)
|
2014-06-16 |
2020-04-29 |
Univ Johns Hopkins |
Compositions and methods for the expression of crispr guide rnas using the h1 promoter
|
|
US20170219596A1
(en)
|
2014-07-14 |
2017-08-03 |
The Regents Of The University Of California |
A protein tagging system for in vivo single molecule imaging and control of gene transcription
|
|
WO2016011080A2
(en)
|
2014-07-14 |
2016-01-21 |
The Regents Of The University Of California |
Crispr/cas transcriptional modulation
|
|
WO2016022866A1
(en)
|
2014-08-07 |
2016-02-11 |
Agilent Technologies, Inc. |
Cis-blocked guide rna
|
|
CN106714845A
(zh)
|
2014-08-11 |
2017-05-24 |
得克萨斯州大学系统董事会 |
通过crispr/cas9介导的基因编辑预防肌营养不良
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
GB201418965D0
(ja)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
MA40880A
(fr)
|
2014-10-30 |
2017-09-05 |
Temple Univ Of The Commonwealth |
Éradication guidée par l'arn du virus jc humain et d'autres polyomavirus
|
|
US11319555B2
(en)
|
2014-11-20 |
2022-05-03 |
Duke University |
Compositions, systems and methods for cell therapy
|
|
EP3221457B1
(en)
|
2014-11-21 |
2019-03-20 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
EP3230451B1
(en)
|
2014-12-12 |
2021-04-07 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
US10190106B2
(en)
*
|
2014-12-22 |
2019-01-29 |
Univesity Of Massachusetts |
Cas9-DNA targeting unit chimeras
|
|
WO2016114972A1
(en)
|
2015-01-12 |
2016-07-21 |
The Regents Of The University Of California |
Heterodimeric cas9 and methods of use thereof
|
|
SG11201706059SA
(en)
|
2015-01-30 |
2017-08-30 |
Univ California |
Protein delivery in primary hematopoietic cells
|
|
EP3256487A4
(en)
|
2015-02-09 |
2018-07-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
CN107532161A
(zh)
|
2015-03-03 |
2018-01-02 |
通用医疗公司 |
具有改变的PAM特异性的工程化CRISPR‑Cas9核酸酶
|
|
US20160281166A1
(en)
|
2015-03-23 |
2016-09-29 |
Parabase Genomics, Inc. |
Methods and systems for screening diseases in subjects
|
|
EP3277816B1
(en)
|
2015-04-01 |
2020-06-17 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy and becker muscular dystrophy
|
|
US20180305689A1
(en)
|
2015-04-22 |
2018-10-25 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
|
KR102535217B1
(ko)
|
2015-04-24 |
2023-05-19 |
에디타스 메디신, 인코포레이티드 |
Ｃａｓ9 분자/가이드 ｒｎａ 분자 복합체의 평가
|
|
WO2016187717A1
(en)
|
2015-05-26 |
2016-12-01 |
Exerkine Corporation |
Exosomes useful for genome editing
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
CN108290933A
(zh)
|
2015-06-18 |
2018-07-17 |
布罗德研究所有限公司 |
降低脱靶效应的crispr酶突变
|
|
WO2017015637A1
(en)
|
2015-07-22 |
2017-01-26 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
CA2990991A1
(en)
|
2015-07-24 |
2017-02-02 |
Basf Se |
Pyridine compounds useful for combating phytopathogenic fungi
|
|
WO2017069829A2
(en)
|
2015-07-31 |
2017-04-27 |
The Trustees Of Columbia University In The City Of New York |
High-throughput strategy for dissecting mammalian genetic interactions
|
|
ES2929110T3
(es)
|
2015-08-25 |
2022-11-24 |
Univ Duke |
Composiciones y métodos para mejorar la especificidad en ingeniería genética usando endonucleasas guiadas por ARN
|
|
US11091780B2
(en)
|
2015-09-18 |
2021-08-17 |
The Regents Of The University Of California |
Methods for autocatalytic genome editing and neutralizing autocatalytic genome editing and compositions thereof
|
|
US20180265859A1
(en)
|
2015-09-23 |
2018-09-20 |
UNIVERSITé LAVAL |
Modification of the dystrophin gene and uses thereof
|
|
US11970710B2
(en)
|
2015-10-13 |
2024-04-30 |
Duke University |
Genome engineering with Type I CRISPR systems in eukaryotic cells
|
|
EP3365357B1
(en)
|
2015-10-23 |
2024-02-14 |
President and Fellows of Harvard College |
Evolved cas9 proteins for gene editing
|
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
|
JP2019507579A
(ja)
|
2015-10-28 |
2019-03-22 |
クリスパー セラピューティクス アーゲー |
デュシェンヌ型筋ジストロフィーの処置のための材料および方法
|
|
US11566052B2
(en)
|
2015-11-11 |
2023-01-31 |
Lonza Ltd. |
CRISPR-associated (Cas) proteins with reduced immunogenicity
|
|
US11306308B2
(en)
|
2015-11-13 |
2022-04-19 |
Massachusetts Institute Of Technology |
High-throughput CRISPR-based library screening
|
|
US12214054B2
(en)
|
2015-11-30 |
2025-02-04 |
Duke University |
Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
|
|
MX2018008344A
(es)
|
2016-01-11 |
2018-12-06 |
Univ Leland Stanford Junior |
Proteinas quimericas y metodos para regular la expresion genica.
|
|
EP3199632A1
(en)
|
2016-01-26 |
2017-08-02 |
ACIB GmbH |
Temperature-inducible crispr/cas system
|
|
EP3413908B1
(en)
|
2016-02-11 |
2024-06-19 |
The Regents of The University of California |
Methods and compositions for modifying a mutant dystrophin gene in a cell's genome
|
|
WO2017165859A1
(en)
|
2016-03-24 |
2017-09-28 |
Research Institute At Nationwide Children's Hospital |
Modified viral capsid proteins
|
|
WO2017180915A2
(en)
|
2016-04-13 |
2017-10-19 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
US11358993B2
(en)
|
2016-04-15 |
2022-06-14 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of B-sarcoglycan and microrna-29 and the treatment of muscular dystrophy
|
|
CN109661470A
(zh)
|
2016-04-15 |
2019-04-19 |
宾夕法尼亚州大学信托人 |
新型aav8突变衣壳和含有其的组合物
|
|
ES2957660T3
(es)
|
2016-05-05 |
2024-01-23 |
Univ Duke |
Composiciones relacionadas con crispr/cas para tratar la distrofia muscular de duchenne
|
|
WO2017201199A1
(en)
|
2016-05-17 |
2017-11-23 |
Duke University |
Compositions and methods for the treatment of prader-willi syndrome
|
|
US20170362635A1
(en)
|
2016-06-20 |
2017-12-21 |
University Of Washington |
Muscle-specific crispr/cas9 editing of genes
|
|
EP3478829A1
(en)
|
2016-06-29 |
2019-05-08 |
Crispr Therapeutics AG |
Materials and methods for treatment of myotonic dystrophy type 1 (dm1) and other related disorders
|
|
KR20190024977A
(ko)
|
2016-06-30 |
2019-03-08 |
사렙타 쎄러퓨틱스 인코퍼레이티드 |
근육 이상증에 대한 엑손 스킵핑 올리고머
|
|
KR20190039703A
(ko)
|
2016-07-05 |
2019-04-15 |
더 존스 홉킨스 유니버시티 |
Crispr/cas9-기반 조성물 및 망막 변성을 치료하기 위한 방법
|
|
WO2018013932A1
(en)
|
2016-07-15 |
2018-01-18 |
Salk Institute For Biological Studies |
Methods and compositions for genome editing in non-dividing cells
|
|
CN109715218A
(zh)
|
2016-07-18 |
2019-05-03 |
嘉安生物治疗有限责任公司 |
用于治疗心脏疾病的组合物和方法
|
|
US20190235624A1
(en)
|
2016-07-19 |
2019-08-01 |
Supereye, Inc. |
Systems and methods for predictive visual rendering
|
|
WO2018017754A1
(en)
|
2016-07-19 |
2018-01-25 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
IL308426A
(en)
|
2016-08-03 |
2024-01-01 |
Harvard College |
Adenosine nuclear base editors and their uses
|
|
EP3497221A4
(en)
|
2016-08-10 |
2020-02-05 |
Duke University |
COMPOSITIONS, SYSTEMS AND METHODS FOR PROGRAMMING IMMUNE CELL FUNCTION BY TARGETED GENE REGULATION
|
|
US11352647B2
(en)
|
2016-08-17 |
2022-06-07 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
JP7308143B2
(ja)
|
2016-08-19 |
2023-07-13 |
ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ |
Ｄｎａメチル化の編集方法
|
|
CA3033939A1
(en)
|
2016-08-19 |
2018-02-22 |
Toolgen Incorporated |
Artificially engineered angiogenesis regulatory system
|
|
KR102594051B1
(ko)
|
2016-08-20 |
2023-10-26 |
아벨리노 랩 유에스에이, 인크. |
단일 가이드 RNA, CRISPR/Cas9 시스템, 및 이의 사용방법
|
|
US20190248854A1
(en)
|
2016-09-23 |
2019-08-15 |
UNIVERSITé LAVAL |
Methods of modifying the dystrophin gene and restoring dystrophin expression and uses thereof
|
|
GB2573062A
(en)
|
2016-10-14 |
2019-10-23 |
Harvard College |
AAV delivery of nucleobase editors
|
|
EP3532616A1
(en)
|
2016-10-28 |
2019-09-04 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus
|
|
CN110382695A
(zh)
|
2016-11-28 |
2019-10-25 |
得克萨斯州大学系统董事会 |
通过crispr/cpf1介导的基因编辑来预防肌营养不良
|
|
US20200056206A1
(en)
|
2016-12-01 |
2020-02-20 |
UNIVERSITé LAVAL |
Crispr-based treatment of friedreich ataxia
|
|
EP3551752A1
(en)
|
2016-12-08 |
2019-10-16 |
The Board of Regents of The University of Texas System |
Dmd reporter models containing humanized duschene muscular dystrophy mutations
|
|
JOP20190166A1
(ar)
|
2017-01-05 |
2019-07-02 |
Univ Texas |
استراتيجية مثلى من أجل تعديلات تخطي إكسون باستخدام crispr/cas9 مع متواليات توجيه ثلاثي
|
|
EP3579858A4
(en)
|
2017-02-07 |
2020-12-23 |
The Regents of The University of California |
GENE THERAPY AGAINST HAPLOINSUFFICIENCY
|
|
JP2018143239A
(ja)
|
2017-03-01 |
2018-09-20 |
エリクサジェン，エルエルシー． |
多能性幹細胞を所望の細胞型へ効率的に分化する方法
|
|
WO2018160908A1
(en)
|
2017-03-03 |
2018-09-07 |
Flagship Pioneering, Inc. |
Methods and systems for modifying dna
|
|
US10687520B2
(en)
|
2017-03-07 |
2020-06-23 |
The Board Of Regents Of The University Of Texas System |
Generation and correction of a humanized mouse model with a deletion of dystrophin exon 44
|
|
WO2018162702A1
(en)
|
2017-03-10 |
2018-09-13 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Nuclease fusions for enhancing genome editing by homology-directed transgene integration
|
|
US11541130B2
(en)
|
2017-03-23 |
2023-01-03 |
DNARx |
Systems and methods for nucleic acid expression in vivo
|
|
CN110892069B
(zh)
|
2017-03-30 |
2024-02-09 |
国立大学法人京都大学 |
基于基因组编辑的外显子跳跃诱导方法
|
|
CA3059757A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Novel type vi crispr orthologs and systems
|
|
US20180305719A1
(en)
|
2017-04-19 |
2018-10-25 |
The Board Of Trustees Of The University Of Illinois |
Vectors For Integration Of DNA Into Genomes And Methods For Altering Gene Expression And Interrogating Gene Function
|
|
JP7398279B2
(ja)
|
2017-05-10 |
2023-12-14 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Ｃｒｉｓｐｒ／ｃａｓ９核送達による細胞ｒｎａの狙いを定めた編集
|
|
EP3420811A1
(en)
|
2017-06-29 |
2019-01-02 |
Paris Sciences et Lettres - Quartier Latin |
Non-human model for neurofibromatosis type 1
|
|
EP3650540A4
(en)
|
2017-07-07 |
2021-03-31 |
Toolgen Incorporated |
Target-specific crispr mutant
|
|
WO2019014122A1
(en)
|
2017-07-08 |
2019-01-17 |
The Brigham And Women's Hospital, Inc. |
METHODS FOR ENHANCING ANTIANGIOGENIC THERAPY AND IMMUNOTHERAPY
|
|
EP3712272A4
(en)
|
2017-07-25 |
2021-10-13 |
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences |
PROCESS FOR MODULATING RNA SPLICE BY INDUCTION OF BASIC MUTATION AT A SPLICE SITE OR BASIC SUBSTITUTION IN A POLYPYRIMIDINE REGION
|
|
WO2019023291A2
(en)
|
2017-07-25 |
2019-01-31 |
Dana-Farber Cancer Institute, Inc. |
COMPOSITIONS AND METHODS FOR PRODUCTION AND DECODING OF GUIDE RNA LIBRARIES AND USES THEREOF
|
|
EP3441461A1
(en)
|
2017-08-11 |
2019-02-13 |
Baylor College of Medicine |
Cd1d-restricted nkt cells as a platform for off-the-shelf cancer immunotherapy
|
|
US20200260698A1
(en)
|
2017-08-18 |
2020-08-20 |
The Board Of Regents Of The University Of Texas System |
Exon deletion correction of duchenne muscular dystrophy mutations in the dystrophin actin binding domain 1 using crispr genome editing
|
|
MA50062A
(fr)
|
2017-08-31 |
2020-07-08 |
Sarepta Therapeutics Inc |
Méthodes permettant de traiter la dystrophie musculaire
|
|
WO2019067786A1
(en)
|
2017-09-29 |
2019-04-04 |
The Regents Of The University Of California |
MULTI-ARM POLYROTAXANE PLATFORM FOR PROTECTED ADMINISTRATION OF NUCLEIC ACIDS
|
|
US11987790B2
(en)
|
2017-10-17 |
2024-05-21 |
Massachusetts Institute Of Technology |
Methods for high-resolution genome-wide functional dissection of transcriptional regulatory regions
|
|
SG11202002186VA
(en)
|
2017-10-19 |
2020-05-28 |
Curevac Ag |
Novel artificial nucleic acid molecules
|
|
US20210268667A1
(en)
|
2017-10-23 |
2021-09-02 |
Stoke Therapeutics, Inc. |
Antisense oligomers for treatment of non-sense mediated rna decay based conditions and diseases
|
|
MA50579A
(fr)
|
2017-11-09 |
2020-09-16 |
Crispr Therapeutics Ag |
Systèmes crispr/cas ou crispr/cpf1 à auto-inactivation (sin) et leurs utilisations
|
|
US12018255B2
(en)
|
2017-12-08 |
2024-06-25 |
University Of Connecticut |
Compositions and methods for treating disorders of genomic imprinting
|
|
CN111727045B
(zh)
|
2017-12-15 |
2024-07-19 |
小利兰·斯坦福大学托管委员会 |
抑制t细胞衰竭的组合物和方法
|
|
WO2019122381A2
(en)
|
2017-12-22 |
2019-06-27 |
Kws Saat Se |
Targeted transcriptional regulation using synthetic transcription factors
|
|
WO2019123014A1
(en)
|
2017-12-22 |
2019-06-27 |
G+Flas Life Sciences |
Chimeric genome engineering molecules and methods
|
|
JP7288282B2
(ja)
|
2017-12-28 |
2023-06-07 |
国立大学法人京都大学 |
標的遺伝子改変用組成物
|
|
WO2019136216A1
(en)
|
2018-01-05 |
2019-07-11 |
The Board Of Regents Of The University Of Texas System |
Therapeutic crispr/cas9 compositions and methods of use
|
|
WO2019144061A1
(en)
|
2018-01-19 |
2019-07-25 |
Duke University |
Genome engineering with crispr-cas systems in eukaryotes
|
|
KR20200124702A
(ko)
|
2018-02-23 |
2020-11-03 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
신규한 cas9 오르소로그
|
|
US20210254049A1
(en)
|
2018-04-20 |
2021-08-19 |
Cellino Biotech, Inc. |
Directed cell fate specification and targeted maturation
|
|
CN112512595A
(zh)
|
2018-05-03 |
2021-03-16 |
哈佛学院校长同事会 |
心脏、骨骼肌和肌肉干细胞中的体内同源性定向修复
|
|
WO2019232069A1
(en)
|
2018-05-30 |
2019-12-05 |
Emerson Collective Investments, Llc |
Cell therapy
|
|
US20210309986A1
(en)
|
2018-07-19 |
2021-10-07 |
The Board Of Trustees Of The University Of Illinois |
Methods for exon skipping and gene knockout using base editors
|
|
US20200109406A1
(en)
|
2018-10-02 |
2020-04-09 |
Sangamo Therapeutics, Inc. |
Engineered genetic modulators
|
|
EP3897748A4
(en)
|
2018-12-20 |
2023-01-25 |
Ohio State Innovation Foundation |
COMPOSITIONS AND METHODS FOR REPROGRAMMING DISEASE MUSCLE SKELETAL CELLS
|
|
BR102019009665A2
(pt)
|
2018-12-21 |
2022-02-08 |
Jacques P. Tremblay |
Modificação da proteína precursora beta amiloide (app) através da edição de base usando o sistema crispr/cas9
|
|
EP3921417A4
(en)
|
2019-02-04 |
2022-11-09 |
The General Hospital Corporation |
ADENINE DNA BASE EDITOR VARIANTS WITH REDUCED OFF-TARGET RNA EDITING
|
|
CN116497067B
(zh)
|
2019-02-13 |
2025-01-24 |
比姆医疗股份有限公司 |
治疗血红素病变的组合物和方法
|
|
JP2022526669A
(ja)
|
2019-04-12 |
2022-05-25 |
デューク ユニバーシティ |
ジストロフィン機能を修復するためのＣＲＩＳＰＲ／Ｃａｓをベースにした塩基編集組成物
|
|
TW202100748A
(zh)
|
2019-04-14 |
2021-01-01 |
美國公爵大學 |
恢復肌縮蛋白功能之基於ｃｒｉｓｐｒ／ｃａｓ之基因組編輯組合物
|
|
AU2020257898A1
(en)
|
2019-04-14 |
2021-11-04 |
Duke University |
AAV vector-mediated deletion of large mutational hotspot for treatment of duchenne muscular dystrophy
|
|
CN114727996A
(zh)
|
2019-06-20 |
2022-07-08 |
细胞基因公司 |
用于治疗白血病或骨髓增生异常综合征的与维奈托克、吉瑞替尼、米哚妥林或其他化合物组合的阿扎胞苷
|
|
EP4010485A4
(en)
|
2019-08-08 |
2023-08-23 |
Duke University |
HIGH-THROUGHPUT SCREENING PLATFORM FOR THE MANIPULATION OF NEXT GENERATION GENE THERAPY VECTORS
|
|
CN114599403A
(zh)
|
2019-08-19 |
2022-06-07 |
杜克大学 |
通过基于crispr/cas9的转录激活物获得的骨骼肌成肌细胞祖细胞谱系的特化
|
|
AU2020331968A1
(en)
|
2019-08-19 |
2022-03-10 |
Duke University |
Compositions and methods for identifying regulators of cell type fate specification
|
|
US20230060409A1
(en)
|
2019-09-20 |
2023-03-02 |
The Uab Research Foundation |
Methods of Treatment of Neurofibromatosis Type 1 (NF1) and NF-1 Mediated Conditions and Compositions for Use in Such Methods
|
|
EP4038204A4
(en)
|
2019-10-02 |
2023-09-13 |
Duke University |
EPIGENETIC MODULATION OF GENOMIC TARGETS TO REGULATE THE EXPRESSION OF GENES ASSOCIATED WITH PWS
|
|
WO2021113536A1
(en)
|
2019-12-03 |
2021-06-10 |
Duke University |
Systems and methods for lipid nanoparticle delivery of gene editing machinery
|
|
EP4126073A4
(en)
|
2020-04-27 |
2024-07-24 |
Duke University |
CRISPR/CAS9 THERAPIES TO CORRECT DUCHENNE MUSCULAR DYSTROPHY BY TARGETED GENOMIC INTEGRATION
|
|
JP2023515710A
(ja)
|
2020-04-27 |
2023-04-13 |
デューク ユニバーシティ |
ＣＲＩＳＰＲ媒介式エクソン欠失用の最適なｇＲＮＡ対を発見するためのハイスループットスクリーニング法
|
|
US20230201375A1
(en)
|
2020-04-27 |
2023-06-29 |
Duke University |
Targeted genomic integration to restore neurofibromin coding sequence in neurofibromatosis type 1 (nf1)
|
|
US20230348870A1
(en)
|
2020-04-27 |
2023-11-02 |
Duke University |
Gene editing of satellite cells in vivo using aav vectors encoding muscle-specific promoters
|
|
CA3182672A1
(en)
|
2020-05-08 |
2021-11-11 |
Duke University |
Chromatin remodelers to enhance targeted gene activation
|
|
EP4200406A1
(en)
|
2020-08-21 |
2023-06-28 |
Julius-Maximilians-Universität Würzburg |
Modified lymphocytes
|
|
JP2023549456A
(ja)
|
2020-10-21 |
2023-11-27 |
デューク ユニバーシティ |
デュシェンヌ型筋ジストロフィーの処置のための大きい変異ホットスポットの二重ａａｖベクター媒介欠失
|
|
WO2022103935A1
(en)
|
2020-11-11 |
2022-05-19 |
The Trustees Of Columbia University In The City Of New York |
Multiplex epigenome editing
|
|
CA3201631A1
(en)
|
2020-11-13 |
2022-05-19 |
Duke University |
Targeted gene regulation of human immune cells with crispr-cas systems
|
|
WO2022133062A1
(en)
|
2020-12-16 |
2022-06-23 |
Epicrispr Biotechnologies, Inc. |
Systems and methods for engineering characteristics of a cell
|
|
US20240141341A1
(en)
|
2021-03-01 |
2024-05-02 |
Duke University |
Systems and methods for genome-wide annotation of gene regulatory elements linked to cell fitness
|
|
US20240252684A1
(en)
|
2021-07-30 |
2024-08-01 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
CA3227103A1
(en)
|
2021-07-30 |
2023-02-02 |
Matthew P. GEMBERLING |
Compositions and methods for modulating expression of frataxin (fxn)
|
|
WO2023137472A2
(en)
|
2022-01-14 |
2023-07-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
|
|
EP4463548A1
(en)
|
2022-01-14 |
2024-11-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
|
US20240058425A1
(en)
|
2022-03-08 |
2024-02-22 |
Duke University |
Systems and methods for genome-wide annotation of gene regulatory elements linked to cell fitness
|
|
WO2023250511A2
(en)
|
2022-06-24 |
2023-12-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression
|
|
WO2024015881A2
(en)
|
2022-07-12 |
2024-01-18 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for targeted transcriptional activation
|
|
WO2024040253A1
(en)
|
2022-08-18 |
2024-02-22 |
Duke University |
Epigenetic modulation of genomic targets to control expression of pws-associated genes
|
|
US12221608B2
(en)
|
2022-08-19 |
2025-02-11 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression
|
|
WO2024064642A2
(en)
|
2022-09-19 |
2024-03-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for modulating t cell function
|
|
WO2024081937A2
(en)
|
2022-10-13 |
2024-04-18 |
Duke University |
Cas12a fusion proteins and methods of using same
|