JP2018094286A - Biological information measurement device and biological information measurement method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a biological information measurement device that can suppress wavelength shift of a spectral part depending on the use angle thereof to measure biological information accurately, and to provide a biological information measurement method.SOLUTION: An angle detection part 80 detects an installation angle of a biological information measurement device 1. The biological information measurement device corrects a control voltage of a spectroscopic element 26 based on the installation angle to suppress wavelength shift of the spectroscopic element 26.SELECTED DRAWING: Figure 8

Description

  The present invention relates to a biological information measuring device and a biological information measuring method using the biological information measuring device.

  Conventionally, a living body that acquires light emitted from a light emitting element present at an irradiation position as a light reception result by the light receiving element present at the light receiving position, and uses the light reception result to acquire biological information about blood vessels and blood in the blood vessels. Information measuring devices are known. The biological information measuring device has a wristwatch type appearance, and is used by being attached and fixed to a body part such as an arm, a foot, or a neck of a subject with a band provided in a main body case.

  Here, the biological information measuring apparatus measures the spectral reflection characteristics of the subject, the output characteristics of the spectroscopic unit change depending on the use environment and usage method, and the light reception result shifts in the wavelength spectroscopic direction. There is a problem that accuracy is lowered.

  With respect to this problem, in Patent Document 1, a shift amount is derived using an emission line spectrum such as a laser, and a decrease in measurement accuracy is suppressed by correcting a shift in the wavelength spectral direction.

JP 2007-192747 A

  However, in the technique described in Patent Document 1, it is necessary to provide the biological information measuring device with an emission line spectrum generating device such as a laser, and the biological information measuring device is used by being attached and fixed to a body part such as a subject's arm, foot, or neck. The biological information measuring device has been a problem in terms of miniaturization.

  SUMMARY An advantage of some aspects of the invention is to solve at least a part of the problems described above, and the invention can be implemented as the following forms or application examples.

  Application Example 1 A biological information measuring apparatus according to this application example is for emitting a light for irradiating a subject, and for separating the reflected light reflected by the subject into reflected light of each wavelength. A biological information measuring device comprising: a spectroscopic unit; and a light receiving unit that receives the reflected reflected light and outputs a light reception signal corresponding to the light intensity, and detects an installation angle of the spectroscopic unit And a correction means for correcting the control voltage of the spectroscopic unit based on the installation angle.

  According to this application example, since the shift in the wavelength spectroscopic direction is corrected by the correcting unit that corrects the control voltage of the spectroscopic unit based on the installation angle of the spectroscopic unit detected by the angle detection unit, a decrease in measurement accuracy is suppressed. be able to. Furthermore, since it is not necessary to provide a separate light source like the bright line spectrum generator, the biological information measuring device can be downsized.

  Application Example 2 In the biological information measuring apparatus according to the application example described above, the spectroscopic unit includes two reflecting plates having reflecting surfaces facing each other, and the distance between the two reflecting plates is set by the control voltage. The spectroscopic unit is a variable spectroscopic unit based on an angle formed by a direction perpendicular to one of the two reflecting plates and a direction in which gravitational acceleration is applied. It is preferable to correct the control voltage.

  The spectroscopic unit may include a spectroscopic unit that includes two reflecting plates having reflecting surfaces facing each other and in which the distance between the two reflecting plates is variable. In this case, if the angle between the direction orthogonal to the reflecting plate and the direction in which the gravitational acceleration is applied changes, the distance between the two reflecting plates also changes, resulting in an inaccurate spectral result. According to this application example, an accurate spectroscopic result can be obtained even if the distance between the two reflectors changes due to a change in the angle between the direction perpendicular to the reflector and the direction in which the gravitational acceleration is applied. .

  Application Example 3 In the biological information measurement device according to the application example described above, it is preferable that the angle detection unit acquires the installation angle for each wavelength to be spectrally separated by the spectroscopic unit.

  According to this application example, since the control voltage of the spectroscopic unit is corrected for each wavelength, a decrease in measurement accuracy can be further suppressed.

  Application Example 4 In the biological information measurement device according to the application example described above, it is preferable that the angle detection unit acquires the installation angle for at least one or more wavelengths to be spectrally separated by the spectroscopic unit.

  According to this application example, the control voltage of the spectroscopic unit is corrected while shortening the time required for setting the installation angle by the angle detection unit, so that a decrease in measurement accuracy can be further suppressed.

  [Application Example 5] A biological information measurement method according to this application example includes a light emitting unit for emitting light for irradiating a subject, and spectroscopic analysis of reflected light reflected by the subject into reflected light of each wavelength. A biological information measuring method of a biological information measuring device, comprising: a spectroscopic unit; and a light receiving unit that receives the reflected reflected light and outputs a light reception signal according to light intensity, wherein the installation angle of the spectroscopic unit And an angle information acquisition step for detecting the control unit, and a correction step for correcting the control voltage of the spectroscopic unit based on the installation angle.

  According to this application example, since the shift in the wavelength spectral direction is corrected by the correcting unit that corrects the control voltage of the spectroscopic unit based on the installation angle detected by the angle detection unit, it is possible to suppress a decrease in measurement accuracy. . Furthermore, since it is not necessary to provide a separate light source like the bright line spectrum generator, the biological information measuring device can be downsized.

  Application Example 6 In the biological information measurement method according to the application example described above, the spectroscopic unit includes two reflecting plates having reflecting surfaces facing each other, and the spectroscopic unit having a variable distance between the two reflecting plates. And the correction step determines the control voltage of the spectroscopic unit based on an angle formed by a direction orthogonal to one of the two reflecting plates and a direction in which gravitational acceleration is applied. It is preferable to correct.

  The spectroscopic unit may include a spectroscopic unit that includes two reflecting plates having reflecting surfaces facing each other and in which the distance between the two reflecting plates is variable. In this case, if the angle between the direction orthogonal to the reflecting plate and the direction in which the gravitational acceleration is applied changes, the distance between the two reflecting plates also changes, resulting in an inaccurate spectral result. According to this application example, an accurate spectroscopic result can be obtained even if the distance between the two reflecting plates changes due to a change in the angle between the direction perpendicular to the reflecting plate and the direction in which the gravitational acceleration is applied.

  Application Example 7 In the biological information measurement method according to the application example described above, it is preferable that the angle information acquisition step acquires the installation angle for each wavelength to be dispersed in the spectroscopic unit.

  According to this application example, since the control voltage of the spectroscopic unit is corrected for each wavelength, a decrease in measurement accuracy can be further suppressed.

  Application Example 8 In the biological information measurement method according to the application example described above, it is preferable that the angle information acquisition step acquires the installation angle for at least one or more wavelengths to be dispersed in the spectroscopic unit.

  According to this application example, the control voltage of the spectroscopic unit is corrected while shortening the time required for setting the installation angle by the angle detection unit, so that a decrease in measurement accuracy can be further suppressed.

The schematic diagram for demonstrating the example of installation of the biological information measuring device which concerns on 1st Embodiment. The schematic plan view which shows the structure of the surface of a biological information measuring device. The schematic plan view which shows the structure of the back surface of a biological information measuring device. The disassembled perspective view which shows the structure of a biological information measuring device. The schematic plan view which shows the structure of a sensor module. The schematic sectional side view which shows the structure of a sensor module. The partial model sectional side view for demonstrating operation | movement of a sensor module. The electric control block diagram of a biological information measuring device. The flowchart of the biometric information measuring method whole. The flowchart which shows the biometric information measurement process of step S2 in detail. The schematic diagram for demonstrating the measurement data analysis process of step S3. The schematic diagram for demonstrating the measurement data analysis process of step S3. The schematic diagram for demonstrating the coping method display process of step S5. The flowchart which shows the biometric information measurement process of step S2 which concerns on 2nd Embodiment in detail.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In the following drawings, the scale of each layer and each member is made different from the actual scale so that each layer and each member can be recognized.

(First embodiment)
<Biological information measuring device>
In the present embodiment, characteristic examples of the biological information measuring apparatus 1 and a biological information measuring method for analyzing blood components using the biological information measuring apparatus 1 will be described with reference to the drawings. A biological information measuring apparatus according to a first embodiment will be described with reference to FIGS. FIG. 1 is a schematic diagram for explaining an installation example of the biological information measuring apparatus 1. As shown in FIG. 1, a biological information measuring device 1 as an information acquisition device is installed on the wrist of a subject 4 as a subject. The biological information measuring device 1 is a medical measuring device that measures a blood component of the subject 4 in a non-invasive manner, and is a medical device. The biological information measuring apparatus 1 measures components in blood flowing through the wrist blood vessel. In this embodiment, for example, the glucose concentration is measured as a blood component. The blood glucose level can be measured by measuring the glucose concentration.

  2 and 3 are schematic plan views showing the structure of the biological information measuring device 1. FIG. 2 shows the front surface of the biological information measuring device 1, and FIG. 3 shows the back surface of the biological information measuring device 1. As shown in FIG. 2, the biological information measuring device 1 has a shape similar to a wristwatch. The biological information measuring device 1 includes an exterior part 5. Fixed bands 6 are provided on the left and right sides of the exterior portion 5 in the figure, and the fixed bands 6 fix the biological information measuring device 1 to a measured portion such as a wrist or an arm of the subject 4. A magic tape (registered trademark) is used for the fixed band 6. In the biological information measuring apparatus 1, the direction in which the fixed band 6 extends is defined as the Y direction, and the direction in which the arm of the subject 4 extends is defined as the X direction. The direction in which the biological information measuring device 1 faces the subject 4 is defined as the Z direction. The X direction, the Y direction, and the Z direction are orthogonal to each other.

  The surface 5 a of the exterior portion 5 is a surface that faces outward when the patient 5 is attached to the subject 4. On the surface 5a of the exterior part 5, an operation switch 7, a touch panel 8 and a speaker 9 as an alarm part are installed. The subject 4 inputs a measurement start instruction using the operation switch 7 or the touch panel 8. Then, measurement result data is displayed on the touch panel 8. A warning sound for alerting the subject 4 is emitted from the biological information measuring device 1 from the speaker 9.

  As shown in FIG. 3, a sensor module 10 including a light receiving portion is installed on the back surface 5 b side of the exterior portion 5. The sensor module 10 is used in close proximity to the skin of the subject 4. The sensor module 10 is a device that irradiates the skin of the subject 4 with measurement light and receives reflected light. The sensor module 10 is a thin image sensor incorporating a light source and a photosensor array. A communication connector 11 for communicating with an external device (not shown) is installed on the back surface 5 b of the exterior part 5. In addition, a power connector 12 is provided for charging a rechargeable battery that is built in by an external charger (not shown).

  FIG. 4 is an exploded perspective view showing the structure of the biological information measuring device 1. As shown in FIG. 4, the biological information measuring device 1 includes a back cover 13, a sensor module 10, a circuit unit 14, a spacer 15, a touch panel 8, a vibration device 16 as an alarm unit, and a front case 17 in this order from the Z direction side. It is configured. The outer cover 5 is configured by the back cover 13 and the front case 17. The sensor module 10, the circuit unit 14, the spacer 15, the touch panel 8, and the vibration device 16 are accommodated in the exterior portion 5. Further, on the circuit unit 14, an angle detection unit 80 such as a gravity sensor that detects an installation angle that is an angle with respect to the direction in which the gravitational acceleration of the sensor module 10 is applied is disposed.

  The back cover 13 is a plate-like member and is a member that comes into contact with the subject 4. The back cover 13 is provided with a rectangular first window portion 13a on the X direction side, and the first window portion 13a is a place where the sensor module 10 is exposed. A light transmissive plate such as glass may be disposed in the first window portion 13a. It is possible to prevent dust from entering the exterior portion 5 through the first window portion 13a. In addition, the sensor module 10 can be prevented from becoming dirty. The back cover 13 is provided with a rectangular second window portion 13b and a third window portion 13c on the −X direction side. The second window portion 13b is a place where the communication connector 11 is exposed, and the third window portion 13c is a place where the power connector 12 is exposed.

  In the sensor module 10, a light emitting element 25 (see FIG. 6) as a light emitting unit, a light receiving element 33 (see FIG. 7) as a light receiving unit, and a spectroscopic element 26 (see FIG. 6) as a spectroscopic unit are installed in a lattice shape. This is a sensor that irradiates the examiner 4 with light and detects the light intensity of reflected light of a specific wavelength. The circuit unit 14 includes a circuit board 18. On the circuit board 18, the vibration device 16, the sensor module 10, the angle detection unit 80, and the electric circuit 21 that drives and controls the touch panel 8 are installed. The electric circuit 21 is composed of a plurality of semiconductor chips. In addition, an operation switch 7, a speaker 9, a communication connector 11, a power connector 12, and a rechargeable storage battery 22 are installed on the circuit board 18. The rechargeable storage battery 22 is electrically connected to the power connector 12 and can be charged via the power connector 12.

  The spacer 15 is a structure installed between the circuit unit 14 and the touch panel 8. Since a plurality of elements are installed on the surface on the −Z direction side of the circuit unit 14, unevenness is formed. The spacer 15 is placed over the circuit board 18 to flatten the surface on the touch panel 8 side. The spacer 15 is provided with a plurality of holes 15 a, an operation switch 7, and a speaker 9. And the vibration device 16 penetrates the hole 15a.

  The touch panel 8 has a structure in which an operation input unit 24 is installed on a display unit 23 as an alarm unit. The display unit 23 is not particularly limited as long as it can display electronic data as an image, and a liquid crystal display device or an OLED (Organic Light Emitting Diode) display device can be used. In the present embodiment, for example, an OLED is used for the display unit 23.

  The operation input unit 24 is an input device in which transparent electrodes are arranged in a grid pattern on the surface of a transparent plate. When the operator touches the transparent electrode, a current flows between the intersecting electrodes, so that the place touched by the operator can be detected. The transparent plate may be a light-transmitting plate, and a resin sheet or a glass plate can be used. The transparent electrode may be a light-transmitting and conductive film. For example, IGO (Indium Gallium Oxide), ITO (Indium Tin Oxide), or ICO (Indium Cerium Oxide) can be used. The display unit 23 displays the measurement status, measurement results, and the like. The operation switch 7 is a switch for operating the biological information measuring device 1 in the same manner as the operation input unit 24. The operator operates the operation input unit 24 and the operation switch 7 to input various instructions such as a blood glucose level measurement start instruction and measurement conditions.

  A vibration device 16 is installed on the + Z direction side of the front case 17. The vibration device 16 can vibrate the exterior portion 5. The biological information measuring device 1 has a function of vibrating the exterior part 5 to alert the subject 4. The vibration device 16 is not particularly limited as long as it can vibrate the exterior portion 5 and members constituting the vibration device 16 are not particularly limited. In the present embodiment, for example, a piezoelectric element is used for the vibration device 16.

  The front case 17 is provided with a plurality of holes 17a through which the operation input unit 24, the operation switch 7, and the speaker 9 are exposed. Then, the sensor module 10 to the touch panel 8 are sandwiched and stored between the back cover 13 and the front case 17.

  FIG. 5 is a schematic plan view showing the structure of the sensor module 10 as seen from the back surface 5b side. FIG. 6 is a schematic side sectional view showing the structure of the sensor module 10. FIG. 7 is a partial schematic side cross-sectional view for explaining the operation of the sensor module 10. As shown in FIG. 5, the light emitting elements 25 are two-dimensionally arranged in a lattice shape in the sensor module 10. A spectroscopic element 26 is installed between the adjacent light emitting elements 25.

  The directions in which the light emitting element 25 and the spectroscopic element 26 are arranged are defined as an X direction and a Y direction. The arrangement intervals in the X direction and the Y direction in the light emitting element 25 and the spectroscopic element 26 are the same. The light emitting element 25 and the spectroscopic element 26 are arranged such that the positions in the X direction and the Y direction are shifted from each other by a predetermined length. As a result, the spectroscopic element 26 has a wide arrangement where the spectroscopic element 26 does not overlap the light emitting element 25 when viewed from the back surface 5b side. The light traveling from the subject 4 side reaches the spectroscopic element 26.

  The light emitting element 25 as a light emitting unit emits light (measurement light) for irradiating the subject 4. In the figure, the first row and the second row are sequentially arranged from the lower side toward the + Y direction, and four light emitting elements 25 are provided so as to surround one spectral element 26.

  When the glucose concentration in the blood is detected, the subject 4 is irradiated with light from the light emitting element 25. The wavelength of light emitted from the light emitting element 25 is 900 nm to 2000 nm with 1450 nm as the center. Glucose in blood absorbs light with wavelengths of 1200 nm, 1600 nm, and 2000 nm well. Accordingly, the glucose concentration in the blood can be detected by irradiating the subject 4 with light from the light emitting element 25. Glucose is also called glucose.

  In order to make the figure easy to see, the light emitting elements 25 are arranged in 9 rows and 9 columns. The number of rows and the number of columns in the arrangement of the light emitting elements 25 and the spectroscopic elements 26 is not particularly limited and can be set as appropriate. For example, the arrangement interval is preferably 1 μm to 1500 μm, and is preferably about 100 μm to 1500 μm, for example, in consideration of the manufacturing cost and measurement accuracy. Further, the configuration is not limited to the configuration in which the light emitting element 25 and the spectroscopic element 26 are stacked, and the light emitting element 25 and the spectroscopic element 26 may be juxtaposed on a plane. In this embodiment, for example, the light emitting elements 25 of 250 rows × 250 columns are installed. The distance between the light emitting elements 25 is not particularly limited, but in the present embodiment, for example, the distance between the light emitting elements 25 is 0.1 mm.

  As shown in FIG. 6, the arrangement of the light emitting elements 25 constitutes a light emitting layer 27 as a light source. The light emitting element 25 is a light emitting unit that emits the measurement light 29. The light emitting element 25 is not particularly limited as long as it can emit near-infrared light having transparency to the subcutaneous tissue. For example, an LED (Light Emitting Diode) or an OLED (Organic Light Emitting Diode) can be used as the light emitting element 25.

  A light shielding layer 28 is provided so as to overlap the light emitting layer 27. The measurement light 29 emitted from the light emitting layer 27 toward the subject 4 is reflected by the subcutaneous tissue of the subject 4 and becomes reflected light 30. The light shielding layer 28 allows light traveling toward the spectroscopic element 26 to pass therethrough and selectively shields other light. A spectral layer 31 is provided so as to overlap the light shielding layer 28. In the spectral layer 31, the spectral elements 26 are arranged in a lattice pattern.

  The spectroscopic element 26 as a spectroscopic unit splits the reflected light 30 reflected by the subject 4 into the reflected light 30 of each wavelength. The spectroscopic element 26 includes a reflecting plate 26a and a reflecting plate 26b having reflecting surfaces facing each other. Electrodes are provided on the reflecting plate 26a and the reflecting plate 26b, and the voltage between the reflecting plate 26a and the reflecting plate 26b can be controlled. The spectroscopic element 26 controls the voltage between the reflecting plate 26 a and the reflecting plate 26 b to change the distance between the reflecting plate 26 a and the reflecting plate 26 b, and the reflected light 30 having a predetermined wavelength is reflected by the spectroscopic element 26. Is configured to pass through.

  The peak wavelengths of glucose are 1200 nm, 1600 nm, and 2000 nm. The blood sugar level can be measured by detecting the transmittance of these three wavelengths. Although the wavelength of the reflected light 30 passing through the spectroscopic element 26 is not particularly limited, in the present embodiment, for example, when detecting glucose, the spectroscopic element 26 passes light having a wavelength of 1500 nm to 1700 nm centering on 1600 nm. However, the present invention is not limited to this, and a plurality of wavelengths other than the wavelengths described above or all wavelengths may be used.

  A light receiving layer 32 is provided so as to overlap the spectral layer 31. In the light receiving layer 32, the light receiving elements 33 are two-dimensionally arranged in a lattice shape. The arrangement of the light receiving elements 33 is the same as the arrangement of the spectroscopic elements 26. Each light receiving element 33 is disposed so as to overlap the spectroscopic element 26 when viewed from the traveling direction of the reflected light 30.

  The light receiving element 33 as a light receiving portion receives the reflected reflected light 30 and outputs a received light signal corresponding to the light intensity, that is, receives the reflected light 30 and outputs an electrical signal corresponding to the amount of received light. The light receiving element 33 may be any element that can convert light intensity into a light receiving signal (electrical signal). For example, an image pickup element such as a charge coupled device image sensor (CCD) or a complementary metal oxide semiconductor image sensor (CMOS) is used. Can do. One light receiving element 33 may include a plurality of elements that receive each wavelength component necessary for calibration. And this sensor module 10 is installed in the back surface 5b of the exterior part 5 so that the surface by the side of the light emitting layer 27 may be a front side, and a front side may face the skin surface of the subject 4. FIG.

  The optical axis of the light emitting element 25 and the optical axis of the light receiving element 33 are in the same direction. The light emitting element 25 emits the measurement light 29 with a predetermined directivity characteristic. The direction with the highest light quantity among the directivity characteristics of the measurement light 29 is defined as the optical axis of the light emitting element. The light receiving element 33 has a predetermined directivity characteristic for detecting the reflected light 30. The direction with the highest sensitivity among the directivity characteristics of the sensitivity is defined as the optical axis of the light receiving element 33. In the sensor module 10, the direction in which the light emission amount is high and the direction in which the light receiving sensitivity is highest are in the same direction. That is, the optical axis of the measurement light 29 and the optical axis of the light receiving element 33 are in the same direction. Therefore, when the subject 4 is placed in the direction of the optical axis of the light emitting element 25 and the optical axis of the light receiving element 33, the sensor module 10 can receive the reflected light 30 with high sensitivity.

  As shown in FIG. 7, when photographing the arrangement of the blood vessel 34, all the light emitting elements 25 of the sensor module 10 are caused to emit light at the same time. A place facing the sensor module 10 is referred to as a measured portion 4a. Then, the measuring light 29 is irradiated to the entire area of the measured part 4 a of the subject 4. The measurement light 29 is reflected by the part to be measured 4 a and becomes reflected light 30. Then, the reflected light 30 is received by all the light receiving elements 33, and a biological image is acquired. When measuring a blood component, the specific light emitting element 25 emits light, and the specific light receiving element 33 receives the reflected light 30.

  FIG. 8 is an electric control block diagram of the biological information measuring apparatus 1. In FIG. 8, the biological information measuring device 1 includes a control device 47 that controls the operation of the biological information measuring device 1. The control device 47 includes a CPU 48 (Central Processing Unit) that performs various arithmetic processes as a processor, and a memory 49 that stores various information. The sensor drive circuit 50, the operation input unit 24, the display unit 23, the angle detection unit 80, the operation switch 7, the speaker 9, the vibration device 16, the communication device 51 as the transmission unit, and the rechargeable storage battery 22 are an input / output interface 52 and a data bus. It is connected to the CPU 48 via 53.

  The sensor drive circuit 50 is a circuit that drives the sensor module 10. The sensor driving circuit 50 drives the light emitting element 25, the spectroscopic element 26, and the light receiving element 33 that constitute the sensor module 10. In the sensor module 10, a light emitting element 25, a spectroscopic element 26, and a light receiving element 33 are two-dimensionally arranged in a lattice shape. The sensor driving circuit 50 turns on and off the light emitting element 25 in accordance with an instruction signal from the CPU 48. The sensor drive circuit 50 sets the wavelength of the reflected light 30 that passes through the spectroscopic element 26 in accordance with the instruction signal from the CPU 48. Further, the sensor drive circuit 50 amplifies the signal of the light intensity of the light received by the light receiving element 33, converts it into a digital signal, and transmits it to the CPU 48.

  The display unit 23 displays predetermined information according to an instruction from the CPU 48. Based on the display content, the operator operates the operation input unit 24 to input the instruction content. This instruction content is transmitted to the CPU 48.

  The angle detection unit 80 detects the installation angle of the spectroscopic element 26 provided in the biological information measuring apparatus 1 with respect to the direction in which the gravitational acceleration is applied according to an instruction from the CPU 48. The detected installation angle is transmitted to the angle correction unit 81 of the CPU 48, and the angle correction data 82 in the memory 49 is selected based on the information. Therefore, the shift in the wavelength spectroscopic direction can be corrected by the correcting unit that corrects the control voltage of the spectroscopic element 26 for each wavelength based on the installation angle detected by the angle detecting unit 80, and thus the decrease in measurement accuracy is suppressed. be able to.

  The speaker 9 is an audio output device, and performs various audio outputs according to instructions from the CPU 48. The speaker 9 outputs a notification sound such as the start or end of blood glucose level measurement or the occurrence of an error.

  The vibration device 16 is a device that vibrates the exterior portion 5. Since the exterior part 5 is in contact with the subject 4, the biological information measuring device 1 can alert the subject 4 by vibrating the exterior part 5. When a sound cannot be emitted from the speaker 9 due to the use environment of the biological information measuring device 1, the subject 4 can be alerted using the vibration device 16.

  The communication device 51 is a device configured by a circuit such as a wired communication circuit or a communication control circuit, and performs communication with an external device (not shown) via the communication connector 11. Note that wireless communication may be performed using the communication device 51 as a wireless communication circuit.

  The rechargeable storage battery 22 supplies power for driving the biological information measuring device 1. The rechargeable storage battery 22 outputs data indicating the amount of charge to the CPU 48. The CPU 48 can detect the electric power stored in the rechargeable storage battery 22. The rechargeable storage battery 22 is connected to the power connector 12 and is charged by an external charger (not shown).

  The memory 49 is a concept including a semiconductor memory such as a RAM and a ROM, and an external storage device such as a hard disk and a DVD-ROM. Functionally, a storage area for storing a system program 54 in which a control procedure for the operation of the biological information measuring apparatus 1 is described, and a blood component measurement program 55 in which a calculation procedure for estimating a blood component is described are stored. A storage area is set. In addition, a storage area for storing a light emitting element list 56 that is data indicating the position of the light emitting element 25 is set.

  In addition, a storage area for storing a light receiving element list 57 that is data indicating the position of the light receiving element 33 is set.

  In addition, the memory 49 is set with a storage area for storing absorption spectrum data 64 that is data of the measured light transmittance of blood. In addition, a memory area for storing blood component value data 65 indicating the blood concentration of the measured blood component is set in the memory 49. In addition, a storage area for storing angle correction data 82 based on the installation angle detected by the angle detector 80 is set in the memory 49. In addition, a storage area for storing determination reference data 88 that is reference data for determining the blood component value data 65 is set. In addition, a storage area for storing coping method data 89, which is data of a coping method when the result of determining the blood component value data 65 is abnormal, is set. In addition, a work area for the CPU 48, a storage area that functions as a temporary file, and other various storage areas are set.

  The CPU 48 performs control for measuring the glucose concentration in the blood according to the system program 54 and the blood component measurement program 55 stored in the memory 49. As a specific function realizing unit, the CPU 48 includes a light emission control unit 66. The light emission control unit 66 performs control to selectively emit light and turn off the plurality of light emitting elements 25. In addition, the CPU 48 includes a light reception control unit 67. The light reception control unit 67 performs control for acquiring digital data of the amount of light received by the plurality of light receiving elements 33. In addition, the CPU 48 includes a filter control unit 68. The filter control unit 68 controls the sensor drive circuit 50 to switch the wavelength that the spectroscopic element 26 passes.

  In addition, the CPU 48 includes a measurement control unit 71. The measurement control unit 71 causes the sensor driving circuit 50 to light the light emitting element 25. Then, the light receiving element 33 is driven by the sensor driving circuit 50 to detect the light intensity of the reflected light 30. This light intensity is the light intensity of light that has passed through the blood vessel 34.

  In addition, the CPU 48 has an absorption spectrum calculation unit 72. The absorption spectrum calculation unit 72 generates a measured absorption spectrum of the blood vessel 34. Specifically, the transmittance T of the blood vessel 34 is calculated based on the light intensity of the light received by the light receiving element 33, and an absorption spectrum is generated. The calculated absorption spectrum is stored in the memory 49 as absorption spectrum data 64. The number of wavelengths λ to be measured need not be plural, but only one. The wavelength λ is changed depending on the blood component to be measured.

  In addition, the CPU 48 has a component value calculation unit 73 as a blood sugar level calculation unit. The component value calculation unit 73 calculates the glucose concentration based on the absorption spectrum. As a method for calculating the absorption spectrum, analysis methods such as multiple regression analysis, principal component regression analysis, PLS regression analysis, and independent component analysis can be used. The calculated value is stored in the memory 49 as blood component value data 65.

  In addition, the CPU 48 includes an analysis calculation unit 92. The analysis calculation unit 92 calculates the tendency of the blood component value data 65 to change.

  In addition, the CPU 48 has a coping method selection unit 93. When the tendency that the blood component value data 65 changes is not good for the subject 4, the handling method selection unit 93 selects a handling method suitable for the subject 4 from the handling methods stored in the handling method data 89. Is displayed on the display unit 23.

  In addition, the CPU 48 includes an angle correction unit 81. The angle correction unit 81 reads a predetermined correction table from the angle correction data 82 based on the installation angle detected by the angle detection unit 80, and transmits it to the filter control unit 68.

  In the present embodiment, each function of the biological information measuring apparatus 1 is realized by program software using the CPU 48. However, each function described above is realized by a single electronic circuit (hardware) that does not use the CPU 48. If possible, such an electronic circuit can also be used.

  As described above, according to the biological information measuring apparatus 1 according to the present embodiment, the spectroscopic element 26 is controlled based on the installation angle with respect to the direction in which the gravitational acceleration of the spectroscopic element 26 detected by the angle detection unit 80 is applied. Since the shift in the wavelength spectroscopic direction is corrected by the correction means for correcting the voltage, it is possible to suppress a decrease in measurement accuracy. Furthermore, since it is not necessary to separately provide a light source such as an emission line spectrum generator for shift correction, the biological information measuring apparatus 1 can be reduced in size.

  Moreover, since the control voltage of the spectroscopic element 26 is corrected for each wavelength, it is possible to further suppress a decrease in measurement accuracy.

<Biological information measurement method>
Next, an information acquisition method using the above-described biological information measuring apparatus 1 will be described with reference to FIGS. FIG. 9 is a flowchart showing the entire biological information measuring method. In the flowchart of FIG. 9, step S <b> 1 is a unit mounting process, in which the operator installs the biological information measuring device 1 on the subject 4. Step S2 is a biological information measurement process. In this step, the measurement target 29 is irradiated with the measurement light 29 and the light receiving element 33 detects the reflected light 30. And it is the process of measuring blood glucose. Step S3 is a measurement data analysis process. In this step, the analysis calculation unit 92 analyzes the blood component value data 65 and analyzes the tendency of the blood glucose concentration to change. Next, the process proceeds to step S4. Step S4 is a coping method selection step. This step is a step of selecting from the coping method data 89 the coping method that the subject 4 performs when the blood glucose concentration tends to increase. Next, the process proceeds to step S5. Step S5 is a coping method display process. This step is a step of displaying the coping method selected in step S4. The process of acquiring glucose concentration information from the subject 4 is completed by the above process.

  FIG. 10 is a flowchart showing in more detail the biological information measurement process of step S2. In the flowchart of FIG. 10, step S <b> 21 is an angle information acquisition step, and the angle detection unit 80 detects the installation angle of the biological information measuring device 1. Next, the process proceeds to step S22. Step S22 is a correction process. The detected installation angle is transmitted to the angle correction unit 81 of the CPU 48, and the angle correction data 82 in the memory 49 is selected based on the information. The selected data is transferred to the filter control unit 68, and the sensor driving circuit 50 performs control to correct the value of the instruction signal (control voltage) output to the spectroscopic element 26. Next, the process proceeds to step S23. Step S23 is an object measurement process, which is a process of irradiating the measurement target 29 with the measurement light 29 from the light emitting element 25 and measuring the light intensity of the reflected light 30 received by the light receiving element 33. In step S24, the above-described steps S21 and S23 are repeated for each output wavelength of the spectroscopic element 26, and when the subject measurement process in the entire wavelength region is completed, the process proceeds to step S25.

  Step S25 is an absorption spectrum calculation process. This step is a step in which the absorption spectrum calculation unit 72 calculates blood transmittance using data of measurement results. Next, the process proceeds to step S26. Step S26 is an average absorption spectrum calculation step, which is a step of calculating an average value of transmittance using blood transmittance at a plurality of measurement locations. Next, the process proceeds to step S27. Step S27 is a blood component concentration calculation step. This step is a step of calculating blood glucose concentration. The biological information measurement process of step S2 shown in FIG.

  11 and 12 are diagrams corresponding to the measurement data analysis step of step S3. As shown in FIG. 11, the transition of blood glucose concentration is analyzed in step S3 shown in FIG. The vertical axis in the figure represents the blood sugar level, and the upper side in the figure is higher than the lower side. The blood glucose level is also referred to as blood glucose concentration. The horizontal axis indicates the measurement time, and the time changes from the left side to the right side in the figure. The blood glucose level measurement line 96 shows an example in which the blood glucose level in the subject 4 changes. The analysis calculation unit 92 calculates the blood sugar level approximate line 96a from the blood sugar level measurement line 96 using the least square approximation method. Whether the blood glucose level is rising or falling can be clarified by the inclination of the blood sugar level approximate line 96a. Furthermore, the rate of change can be clarified from the slope of the blood sugar level approximate line 96a.

  The analysis calculation unit 92 compares the blood sugar level approximate line 96a with the upper limit determination value 97 and the lower limit determination value 98. If the blood sugar level approximate line 96a is equal to or lower than the upper limit determination value 97 and lower than the lower limit determination value 98, it is determined to be normal. When the blood glucose level approximate line 96a tends to be higher than the upper limit determination value 97, it is determined as hyperglycemia. Further, when the blood sugar level approximate line 96a tends to be lower than the lower limit determination value 98, it is determined that the blood sugar level is low. In the example of the blood glucose level measurement line 96, it can be seen that the blood glucose level of the subject 4 is hyperglycemia. The method for determining whether the blood glucose level is high or low is not limited to this, and various methods may be adopted.

  FIG. 12 shows another example in which the blood glucose level in the subject 4 changes. The blood sugar level measurement line 101 shows an example in which the blood sugar level in the subject 4 changes. A blood glucose level approximate line 101 a indicates an approximate line of the blood glucose level measurement line 101. The blood sugar level approximate line 101a is found to be normal because it falls between a value higher than the upper limit determination value 97 and between the upper limit determination value 97 and the lower limit determination value 98.

  In the coping method selection step of step S4 shown in FIG. 9, whether the blood glucose level is higher or lower than the upper limit determination value 97 and the lower limit determination value 98 and the inclination of the blood glucose level approximate line are referred to. The coping method data 89 of the memory 49 stores each coping method in the case of hyperglycemia and hypoglycemia. The coping method selection unit 93 selects a method that seems to be optimal from the list of coping methods in the coping method data 89.

  Each of the coping methods of the coping method data 89 is provided with an index, and coping methods are prepared according to the degree of hyperglycemia and hypoglycemia. Therefore, the coping method selection unit 93 can easily select the blood glucose level approximated line in the subject 4 and the result of comparison with the upper limit determination value 97 and the lower limit determination value 98.

  FIG. 13 is a diagram corresponding to the coping method display step of step S5. As shown in FIG. 13, in step S5 in FIG. 9, the coping method selection unit 93 sets the blood glucose level of the subject 4 and the selected coping method, for example, “The blood sugar level is rising. “Let's keep a light exercise” on the touch panel 8.

  As described above, according to the biological information measuring method using the biological information measuring apparatus 1 according to the present embodiment, based on the installation angle with respect to the direction in which the gravitational acceleration of the spectroscopic element 26 detected by the angle detector 80 is applied. Thus, since the shift in the wavelength spectroscopic direction is corrected by the correcting means for correcting the control voltage of the spectroscopic element 26 for each wavelength, it is possible to suppress a decrease in measurement accuracy.

(Second Embodiment)
FIG. 14 is a flowchart showing in more detail the biological information measurement process in the second embodiment. A biological information measuring method using the biological information measuring apparatus 1 according to the present embodiment will be described with reference to this drawing. In addition, about the same component as 1st Embodiment, the same number is used and the overlapping description is abbreviate | omitted.

  In the flowchart of FIG. 14, step S31 is an angle information acquisition step. In the first embodiment, the installation angle of the biological information measuring device 1 is detected by the angle detection unit 80 for each output wavelength of the spectroscopic element 26. However, in this embodiment, the installation angle is detected for only one arbitrary wavelength. Next, the process proceeds to step S32. Step S32 is a correction process. The detected installation angle is transmitted to the angle correction unit 81 of the CPU 48, and the angle correction data 82 in the memory 49 is selected based on the information. The selected data is transferred to the filter control unit 68, and the sensor driving circuit 50 performs control (correction means) for correcting the value of the instruction signal (control voltage) output to the spectroscopic element 26. Next, the process proceeds to step S33. Step S33 is an object measurement step, which is a step of irradiating the measurement portion 29 with the measurement light 29 from the light emitting element 25 and measuring the light intensity of the reflected light 30 received by the light receiving element 33. Then, when step S33 is completed for all wavelengths, the process proceeds to step S34.

  Step S34 is an absorption spectrum calculation step. This step is a step in which the absorption spectrum calculation unit 72 calculates blood transmittance using data of measurement results. Next, the process proceeds to step S35. Step S35 is an average absorption spectrum calculation step, which is a step of calculating an average value of transmittance using the blood transmittance at a plurality of measurement locations. Next, the process proceeds to step S36. Step S36 is a blood component concentration calculation step. This step is a step of calculating blood glucose concentration. The biological information measurement process of step S2 shown in FIG. In the present embodiment, the installation angle is detected for only one arbitrary wavelength in the output wavelength of the spectroscopic element 26. However, the present invention is not limited to this. For any two or more wavelengths among the output wavelengths. A method of detecting the installation angle may be used.

  As described above, according to the biological information measuring method using the biological information measuring apparatus 1 according to the present embodiment, the installation angle for at least one or more wavelengths to be dispersed by the spectroscopic element 26 is acquired. In addition to the effects of the first embodiment, the control voltage of the spectroscopic element 26 is corrected while reducing the time required for obtaining the installation angle by the angle detection unit 80, so that it is possible to further suppress the decrease in measurement accuracy.

  Note that the present invention is not limited to the above-described embodiment, and various modifications and improvements can be added to the above-described embodiment. A modification will be described below.

(Modification 1)
In the second embodiment described above, the installation angle is detected for only one arbitrary wavelength, but the installation angles for a plurality of wavelengths may be detected.

(Modification 2)
In the first embodiment described above, the glucose concentration in the blood component was calculated. Not limited to this, the blood oxygen concentration may be measured using the permeability of hemoglobin. Hemoglobin can be detected with the measuring light 29 having a wavelength of around 650 nm. Therefore, the wavelength of the reflected light 30 that the spectroscopic element 26 passes is set to around 650 nm. Then, the blood oxygen concentration can be measured by calculating the transmittance. In addition, other component concentrations such as lipids may be calculated. Further, not only blood vessels but also the concentration of lymph fluid components in lymph vessels may be measured and calculated. In addition, the component concentration of cerebrospinal fluid may be measured and calculated. In addition, you may use for the test | inspection of animals other than a human body. Further, the biological information measuring device 1 may be used as a measuring device for liquid components and concentrations such as fruit of plants other than animals.

(Modification 3)
In the first embodiment described above, the light emitting element 25 is installed in the sensor module 10. The light emitting element 25 may be removed from the sensor module 10. Then, the measurement portion 29 may be irradiated with the measurement light 29 from a light source different from the light emitting element 25. Since the sensor module 10 does not have the light emitting element 25, the sensor module 10 can be manufactured with high productivity.

  DESCRIPTION OF SYMBOLS 1 ... Living body information measuring device, 4 ... Subject as a test object, 8 ... Touch panel, 10 ... Sensor module, 23 ... Display part, 25 ... Light emitting element as a light emission part, 26 ... Spectral element as a spectroscopic part, 29 ... Measurement Light, 30 ... Reflected light, 33 ... Light receiving element as light receiving unit, 47 ... Control device, 48 ... CPU, 49 ... Memory, 50 ... Sensor drive circuit, 52 ... Input / output interface, 53 ... Data bus, 54 ... System program 55 ... Blood component measurement program, 65 ... Blood component value data, 73 ... Component value calculation unit, 80 ... Angle detection unit, 81 ... Angle correction unit, 82 ... Angle correction data, 88 ... Judgment reference data, 89 ... Coping method Data, 92 ... analytical calculation unit, 93 ... coping method selection unit.

Claims (8)

A light emitting unit for emitting light for irradiating the subject;
A spectroscopic unit for splitting the reflected light reflected by the subject into reflected light of each wavelength;
A biological information measuring device comprising: a light receiving unit that receives the reflected reflected light and outputs a light reception signal corresponding to the light intensity;
An angle detection unit for detecting an installation angle of the spectroscopic unit;
A biological information measuring apparatus comprising: a correcting unit that corrects a control voltage of the spectroscopic unit based on the installation angle. The biological information measuring device according to claim 1,
The spectroscopic unit is a spectroscopic unit that includes two reflecting plates having reflecting surfaces facing each other, and the distance between the two reflecting plates is variable by the control voltage,
The correction unit corrects the control voltage of the spectroscopic unit based on an angle formed by a direction perpendicular to one of the two reflection plates and a direction in which gravitational acceleration is applied. A biological information measuring device characterized by the above. In the biological information measuring device according to claim 1 or 2,
The biological information measuring device, wherein the angle detection unit acquires the installation angle for each wavelength to be spectrally separated by the spectroscopic unit. In the biological information measuring device according to claim 1 or 2,
The said angle detection part acquires the said installation angle about the at least 1 or more wavelength spectrumd in the said spectroscopy part, The biological information measuring device characterized by the above-mentioned. A light emitting unit for emitting light for irradiating the subject;
A spectroscopic unit for splitting the reflected light reflected by the subject into reflected light of each wavelength;
A biological information measuring method for a biological information measuring device, comprising: a light receiving unit that receives the reflected reflected light and outputs a light reception signal corresponding to light intensity,
An angle information acquisition step of detecting an installation angle of the spectroscopic unit;
A correction step of correcting the control voltage of the spectroscopic unit based on the installation angle;
A biological information measuring method comprising: The biological information measuring method according to claim 5,
The spectroscopic unit is a spectroscopic unit that includes two reflecting plates having reflecting surfaces facing each other, and the distance between the two reflecting plates is variable by the control voltage,
In the correcting step, the control voltage of the spectroscopic unit is corrected based on an angle formed by a direction orthogonal to one of the two reflecting plates and a direction in which gravitational acceleration is applied. A biological information measuring method as a feature. The biological information measuring method according to claim 5 or 6,
In the biological information measurement method, the angle information acquisition step acquires the installation angle for each wavelength to be dispersed in the spectroscopic unit. The biological information measuring method according to claim 5 or 6,
The said angle information acquisition process acquires the said installation angle about the at least 1 or more wavelength which carries out spectroscopy in the said spectroscopy part, The biological information measuring method characterized by the above-mentioned.

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