JP2015013827A - Method for increasing adhering amount of moisturizing component - Google Patents
Method for increasing adhering amount of moisturizing component Download PDFInfo
- Publication number
- JP2015013827A JP2015013827A JP2013140720A JP2013140720A JP2015013827A JP 2015013827 A JP2015013827 A JP 2015013827A JP 2013140720 A JP2013140720 A JP 2013140720A JP 2013140720 A JP2013140720 A JP 2013140720A JP 2015013827 A JP2015013827 A JP 2015013827A
- Authority
- JP
- Japan
- Prior art keywords
- moisturizing component
- moisturizing
- keratin
- amount
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 52
- 238000000034 method Methods 0.000 title claims abstract description 21
- 230000001965 increasing effect Effects 0.000 title claims abstract description 17
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- 102000011782 Keratins Human genes 0.000 claims abstract description 28
- 239000001913 cellulose Substances 0.000 claims abstract description 15
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- -1 fatty acid ester Chemical class 0.000 claims description 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 9
- 239000000194 fatty acid Substances 0.000 claims description 9
- 229930195729 fatty acid Natural products 0.000 claims description 9
- 150000005846 sugar alcohols Polymers 0.000 claims description 5
- 230000002500 effect on skin Effects 0.000 abstract 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
本発明は、皮膚の成分であるケラチンに対する保湿成分の付着量を増加する方法に関する。 The present invention relates to a method for increasing the amount of a moisturizing component attached to keratin, which is a skin component.
従来、皮膚の乾燥状態を改善するために保湿する方法として、皮膚との密着性が良く、疎水性を有する化合物を用いて経表皮性水分損失を抑制する方法や、吸湿剤、保湿剤を皮膚料基剤中に配合することにより、水和効果を高める方法等が用いられている。
経表皮性水分損失を抑制する方法にはワセリン軟膏や油中水型乳化物などの閉塞剤が用いられる。また、水和効果を高める方法にはヒアルロン酸、キチンなどの多糖類、コラーゲン、エラスチンなどのタン白質類、ソルビトール、エチレングリコール、グリセリンなどの多価アルコール類、及びピロリドンカルボン酸ソーダ、乳酸ソーダなどの有機酸塩類等が用いられる。
Conventionally, as a method of moisturizing in order to improve the dry state of the skin, a method of suppressing transepidermal water loss using a compound having good adhesion to the skin and having hydrophobicity, a hygroscopic agent, and a moisturizing agent are applied to the skin. For example, a method for enhancing the hydration effect by blending in a base is used.
Occlusion agents such as petrolatum ointment and water-in-oil emulsions are used as a method for suppressing transepidermal water loss. In addition, methods for enhancing the hydration effect include polysaccharides such as hyaluronic acid and chitin, proteins such as collagen and elastin, polyhydric alcohols such as sorbitol, ethylene glycol and glycerin, pyrrolidone carboxylate soda and lactate soda. Organic acid salts and the like are used.
しかしながら、上記保湿方法において、保湿効果を高めるために保湿剤等を化粧料に多量に配合すると、ベタベタ感やヌメリ感等の不快な感触を与えることがある。そこで、これらの改善及び経時や微生物に対する安定性向上の観点から、優れた保湿効果を有する化合物として、側鎖にポリエチレングリコール構造を有する化合物の検討などが報告されている（例えば特許文献１参照）。 However, in the above moisturizing method, if a large amount of a moisturizing agent or the like is added to the cosmetic to enhance the moisturizing effect, an unpleasant feeling such as a sticky feeling or a slimy feeling may be given. Therefore, from the viewpoint of these improvements and the improvement of aging and stability against microorganisms, studies have been made on compounds having a polyethylene glycol structure in the side chain as compounds having an excellent moisturizing effect (see, for example, Patent Document 1). .
皮膚への保湿効果を高める方法として従来検討されているのは、保湿効果を有する化合物や組成物そのものの発明や、保湿剤の使用回数や使用量を増加する方法である。また保湿効果に係る評価も官能的なものであって、皮膚の成分であるケラチンに対する影響を確認したものはない。
そこで本発明は、より少ない量で保湿成分の効果を長期的、効率的に得られるように、皮膚の成分であるケラチンに対する保湿成分の付着量そのものを増加する方法を提供するものである。
Conventionally studied as a method of enhancing the moisturizing effect on the skin are the invention of the compound or composition itself having the moisturizing effect, and the method of increasing the number and use of the moisturizing agent. Moreover, the evaluation regarding a moisturizing effect is also sensual, and there is no one that has confirmed the influence on keratin, which is a component of skin.
Therefore, the present invention provides a method for increasing the amount of moisturizing component adhering to keratin, which is a skin component, so that the effect of the moisturizing component can be obtained for a long time and in a small amount.
本発明者らは、前記課題を解決するために鋭意検討した結果、カチオン化セルロースを用いることにより、保湿成分のケラチンに対する付着量を顕著に増加させることができることを見出し、本発明を完成するに至った。 As a result of intensive studies to solve the above problems, the present inventors have found that the amount of moisturizing component attached to keratin can be remarkably increased by using cationized cellulose, thereby completing the present invention. It came.
すなわち本発明は以下の（１）又は（２）によって達成されるものである。
（１）カチオン化セルロースを用いて、ケラチンに対する保湿成分の付着量を増加する方法。
（２）前記保湿成分が、多価アルコール及び脂肪酸エステルの少なくともいずれか一方である、前記（１）に記載の保湿成分の付着量を増加する方法。
That is, the present invention is achieved by the following (1) or (2).
(1) A method of increasing the amount of moisturizing component attached to keratin using cationized cellulose.
(2) The method of increasing the adhesion amount of the moisturizing component according to (1), wherein the moisturizing component is at least one of a polyhydric alcohol and a fatty acid ester.
本発明によって、皮膚の成分であるケラチンに対する保湿成分の付着量を顕著に増加させることができる。そのため、保湿成分の使用量を少量としても、従来と同等以上の保湿効果が期待される。さらに保湿成分の付着量が増加することから、保湿効果の持続性が期待できる。 According to the present invention, the amount of moisturizing component attached to keratin, which is a skin component, can be remarkably increased. Therefore, even if the amount of the moisturizing component used is small, a moisturizing effect equivalent to or higher than the conventional one is expected. Furthermore, since the adhesion amount of the moisturizing component is increased, the durability of the moisturizing effect can be expected.
本発明は、カチオン化セルロースを用いて、ケラチンに対する保湿成分の付着量を増加する方法を提供するものである。 The present invention provides a method for increasing the amount of moisturizing component attached to keratin using cationized cellulose.
本発明において、カチオン化セルロースとしては、第４級アンモニウムからなるカチオン基を導入し、全体としてカチオン性を有するセルロース誘導体であって、具体的には、塩化Ｏ−〔２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル〕ヒドロキシエチルセルロース（別称「ポリクオタニウム１０」）が挙げられる。
これらの中において、分子量やカチオン化度の異なるものがあるが、本発明の効果を奏する限り適宜選択して用いることができ、分子量としては、例えば、１０，０００〜３，０００，０００の範囲が好ましく、さらには５０，０００〜２，０００，０００の範囲がより好ましい。またカチオン化度は、窒素原子含有率（質量％）として、例えば、０．１〜５質量％の範囲が好ましい。
上記の範囲より選択されたカチオン化セルロースは、ケラチンに対する保湿成分の付着量を顕著に増加させることができ、また馴染みやすいこと等から、本発明において好適に用いることができる。
なおカチオン化セルロースとしては、上記の他にも、例えば、塩化Ｏ−〔２−ヒドロキシ−３−（ラウリルジメチルアンモニオ）プロピル〕ヒドロキシエチルセルロース等を用いることができる。
これらは単独で用いても、複数を組み合わせて用いてもよい。
In the present invention, the cationized cellulose is a cellulose derivative having a cation group composed of quaternary ammonium and having a cationic property as a whole, specifically, O- [2-hydroxy-3- (chloride) Trimethylammonio) propyl] hydroxyethylcellulose (also known as “polyquaternium 10”).
Among these, there are those having different molecular weights and cationization degrees, but they can be appropriately selected and used as long as the effects of the present invention are exhibited. The molecular weight is, for example, in the range of 10,000 to 3,000,000. Is more preferable, and the range of 50,000 to 2,000,000 is more preferable. The degree of cationization is preferably in the range of, for example, 0.1 to 5% by mass as the nitrogen atom content (% by mass).
The cationized cellulose selected from the above range can be suitably used in the present invention because it can remarkably increase the amount of the moisturizing component attached to keratin, and is easily adapted.
In addition to the above, for example, O- [2-hydroxy-3- (lauryldimethylammonio) propyl] hydroxyethylcellulose can be used as the cationized cellulose.
These may be used alone or in combination.
本発明においては、カチオン化セルロースを保湿成分と共に使用することにより、皮膚の構成成分であるケラチンに対する保湿成分の付着量そのものを増加することができる。
ケラチンに対する保湿成分の付着量が向上することで、保湿成分の使用量を少量にしても、従来と同等以上の保湿効果を得ることができることからロスがなく、効率的である。また、ケラチンに付着する保湿成分が増加することから、保湿効果がより長期に渡って持続されることが期待される。
また、本発明に係る方法を連用（一定期間連続して実施）すると、さらに保湿効果の向上が期待される。
In the present invention, by using cationized cellulose together with a moisturizing component, the adhesion amount of the moisturizing component to keratin, which is a constituent component of the skin, can be increased.
By improving the adhesion amount of the moisturizing component to keratin, even if the amount of the moisturizing component used is small, a moisturizing effect equivalent to or higher than that of the conventional one can be obtained, which is efficient without loss. Moreover, since the moisturizing component adhering to keratin increases, it is expected that the moisturizing effect is sustained over a longer period.
Further, when the method according to the present invention is used continuously (continuously performed for a certain period), further improvement of the moisturizing effect is expected.
本発明における保湿成分とは、例えば、ポリエチレングリコール、グリセリン、１，３−ブチレングリコール、プロピレングリコール、ジプロピレングリコール、ジグリセリン、イソプレングリコール、１，２−ペンタンジオール、２，４−ヘキシレングリコール、１，２−ヘキサンジオール、１，２−オクタンジオール等の多価アルコール；オクタン酸セチル、乳酸ミリスチル、乳酸セチル、ミリスチン酸ミリスチル、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、アジピン酸イソプロピル、ステアリン酸ブチル等の脂肪酸エステル；モモ、ヘチマ、アロエ、マロニエ、クマザサ、シラカバ、トマト、キュウリ、カキ、リンゴ、ミカン等の植物エキス；ワカメ、コンブ、イワノリ等の海藻エキス；ホホバ油、アボガド油、アーモンド油、ヌカ油、オリーブ油、カカオ脂、ゴマ油、パーシック油、ヒマシ油、ヤシ油、ミンク油、牛脂、豚脂、大豆油等の天然油脂；カルナウバロウ、鯨ロウ、ミツロウ、ラノリン等のロウ；流動パラフィン、白色ワセリン、セレシン、スクワラン、スクワレン等の炭化水素；ミリスチン酸、ラウリン酸、パルミチン酸、ステアリン酸、ベヘニン酸、オレイン酸、リノール酸、ラノリン酸等の脂肪酸；ラウリルアルコール、セチルアルコール、ステアリルアルコール、オレイルアルコール等のアルコール；モノグリセライド、トリグリセライド等の合成油脂；ソルビトール、ブドウ糖、ショ糖、キシロース、エリスリトール、マンニトール、トレハロース、キシリット、ヒアルロン酸、ヒアルロン酸ナトリウム等の糖；アスコルビン酸及びその塩、トコフェロール、酢酸トコフェロール、パントテン酸及びその塩、リポ酸、フェルラ酸、γ−オリザノール、カルニチン等のビタミン；米ぬかエキス、米胚芽油、尿素、セラミド等が挙げられる
これらの中でも、カチオン化セルロースによってケラチンへ付着しやすく、また馴染みやすいこと等から、多価アルコールおよび脂肪酸エステルが好ましく、その中でもグリセリン及びミリスチン酸イソプロピルがより好ましい。
これらは単独で用いても、複数を組み合わせて用いてもよい。
Examples of the moisturizing component in the present invention include polyethylene glycol, glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, Polyhydric alcohols such as 1,2-hexanediol and 1,2-octanediol; cetyl octoate, myristyl lactate, cetyl lactate, myristyl myristate, isopropyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, etc. Fatty acid esters; plant extracts such as peach, loofah, aloe, maroni, kumazasa, birch, tomato, cucumber, oyster, apple, mandarin; seaweed extract such as wakame, kombu, iwanori; jojoba oil, avocado oil, armo Natural oils such as dough oil, nutka oil, olive oil, cacao butter, sesame oil, persic oil, castor oil, palm oil, mink oil, beef tallow, lard, soybean oil; wax such as carnauba wax, whale wax, beeswax, lanolin; Hydrocarbons such as paraffin, white petrolatum, ceresin, squalane, squalene; fatty acids such as myristic acid, lauric acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, lanolinic acid; lauryl alcohol, cetyl alcohol, stearyl alcohol Alcohols such as oleyl alcohol; synthetic fats and oils such as monoglyceride and triglyceride; sugars such as sorbitol, glucose, sucrose, xylose, erythritol, mannitol, trehalose, xylit, hyaluronic acid, sodium hyaluronate; ascorbic acid and Vitamins such as salt, tocopherol, tocopherol acetate, pantothenic acid and salts thereof, lipoic acid, ferulic acid, γ-oryzanol, carnitine; rice bran extract, rice germ oil, urea, ceramide, etc. Among these, cationized cellulose Polyhydric alcohols and fatty acid esters are preferred because they are easily attached to and familiar with keratin, among which glycerin and isopropyl myristate are more preferred.
These may be used alone or in combination.
本発明に係る方法は、例えば、化粧水、乳液、クリーム、ローション、美容液、化粧品、入浴剤、軟膏等の非治療的な使用態様が挙げられる。
これらの使用態様の場合、製品全体におけるカチオン化セルロースの添加量は０．１〜１０質量％が、本発明の効果を奏すると共に、馴染みがよく、べたつき感がないこと等から好ましく、０．１〜３質量％がより好ましい。
上記の使用態様においては、本発明の効果を損なわない限り、カチオン化セルロース及び保湿成分とともに、他の成分を使用してもよく、例えば、溶媒、香料、界面活性剤、色素、生薬、酵素、高分子化合物、無機塩等が挙げられる。
Examples of the method according to the present invention include non-therapeutic use modes such as lotion, milky lotion, cream, lotion, cosmetic liquid, cosmetics, bath preparation, ointment and the like.
In the case of these usage modes, the addition amount of cationized cellulose in the entire product is preferably from 0.1 to 10% by mass because the effects of the present invention are exhibited, familiarity is not present, and there is no sticky feeling. -3 mass% is more preferable.
In the above use mode, other components may be used together with the cationized cellulose and the moisturizing component as long as the effects of the present invention are not impaired. For example, a solvent, a fragrance, a surfactant, a pigment, a crude drug, an enzyme, Examples thereof include polymer compounds and inorganic salts.
具体的には、水、メタノール、エタノール、プロパノール、ブタノール等の溶媒；ラベンダー油、ジャスミン油、レモン油、スギ油、ヒノキ油、ゲラニオール、シトロネラール、オイゲノール、リモネン、フェネチルアルコール等の香料；グリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシエチレンヒマシ油、ポリグリセリン脂肪酸エステル、ブロックポリマー等の非イオン性界面活性剤；α−オレフィンスルホン酸ナトリウム、ラウリル硫酸ナトリウム、ポリオキシエチレンラウリル硫酸ナトリウム等の陰イオン性界面活性剤；アルキルベタイン、２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタイン等の両性界面活性剤；アルキルアミン塩、第四級アンモニウム塩等の陽イオン性界面活性剤；青色１号、赤色１０６号、黄色４号、緑色３号、クロロフィル、リボフラビン、ベニバナ等の色素；カノコソウ、カミツレ、ガイヨウ、カンピ、ウイキョウ、ケイガイ、ケイヒ、ショウキョウ、ジャスミン、センキュウ、ショウブ、ソウジュツ、トウキ、トウヒ、ドクカツ、ビャクシ、ビャクジュツ等の生薬；トリプシン、パパイン、プロテアーゼ、リゾチーム、ペプシン等の酵素；アラビアゴム、トラガントガム、グアーガム、ローカストビーンガム、ゼラチン、セラック、ロジン、カゼイン、カルボキシメチルセルロースナトリウム、ヒドロキシエチルセルロース、アルギン酸ナトリウム、結晶セルロース等の高分子化合物；塩化ナトリウム、塩化カリウム、炭酸ナトリウム、炭酸マグネシウム、炭酸水素ナトリウム、セスキ炭酸ナトリウム、硫酸ナトリウム、硫酸アルミニウム、硝酸ナトリウム、硝酸カリウム、リン酸ナトリウム、ポリリン酸ナトリウム、リン酸水素カルシウム、イオウ、無水ケイ酸、タルク、水酸化ナトリウム、ホウ砂、酸化カルシウム等が挙げられる。 Specifically, solvents such as water, methanol, ethanol, propanol, butanol; fragrances such as lavender oil, jasmine oil, lemon oil, cedar oil, cypress oil, geraniol, citronellal, eugenol, limonene, phenethyl alcohol; glycerin fatty acid ester , Nonionic surfactants such as sorbitan fatty acid ester, polyoxyethylene castor oil, polyglycerin fatty acid ester and block polymer; anionic interfaces such as sodium α-olefin sulfonate, sodium lauryl sulfate, sodium polyoxyethylene lauryl sulfate Activating agents; amphoteric surfactants such as alkylbetaines and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaines; cationic interfaces such as alkylamine salts and quaternary ammonium salts Sexual agents: Blue No. 1, Red No. 106, Yellow No. 4, Green No. 3, pigments such as chlorophyll, riboflavin, safflower, etc .; Herbal medicines such as trypsin, papain, protease, lysozyme, pepsin; gum arabic, tragacanth gum, guar gum, locust bean gum, gelatin, shellac, rosin, casein, carboxymethylcellulose Polymer compounds such as sodium, hydroxyethyl cellulose, sodium alginate, crystalline cellulose; sodium chloride, potassium chloride, sodium carbonate, magnesium carbonate, sodium bicarbonate, sesquicarbonate Examples include sodium, sodium sulfate, aluminum sulfate, sodium nitrate, potassium nitrate, sodium phosphate, sodium polyphosphate, calcium hydrogen phosphate, sulfur, anhydrous silicic acid, talc, sodium hydroxide, borax, calcium oxide and the like.
本発明に係る方法において、ケラチンに対する保湿成分の付着量は、直接ケラチンへの保湿成分の付着量を測定しても良く、また、保湿成分を含む溶液における調製時の保湿成分の含有量と、該溶液をケラチンと接触させた後の保湿成分の含有量との差から求めることもできる。なお、保湿成分の含有量は、各種分析方法によって測定することができ、例えば、ガスクロマトグラフィーにより測定することができる。 In the method according to the present invention, the amount of the moisturizing component attached to the keratin may be directly measured by the amount of the moisturizing component attached to the keratin, and the content of the moisturizing component at the time of preparation in the solution containing the moisturizing component; It can also be determined from the difference from the moisturizing component content after contacting the solution with keratin. The content of the moisturizing component can be measured by various analysis methods, for example, by gas chromatography.
以下、実施例により本発明を具体的に説明する。ただし、本発明はこれらの実施例のみに限定されるものではない。 Hereinafter, the present invention will be described specifically by way of examples. However, the present invention is not limited to only these examples.
（試験例１：濃グリセリン）
カチオン化セルロースとしてポリクオタニウム１０（商品名：カチナールＬＣ−１００、東邦化学工業社製）を、保湿成分として濃グリセリンを用い、表１に記載の検体Ａ〜Ｅを調製した。
次に検体Ａ〜Ｅを精製水で１００倍希釈して１０ｍＬを秤量し、羊毛由来のケラチン（商品名：Ｋｅｒａｔｉｎ ｆｒｏｍ ｗｏｏｌ、東京化成工業社製）５００ｍｇと共に遠心管に入れた。そして遠心管を４０℃の温水中で１５分間、１２０回／分の条件で振盪し、その後、遠心した（３５００ｒｐｍ、１２分）。得られた上清を濃縮後、ガスクロマトグラフィーを用いて内標準法で濃グリセリンを定量した。
(Test Example 1: Concentrated glycerin)
Samples A to E shown in Table 1 were prepared using polyquaternium 10 (trade name: Kachinal LC-100, manufactured by Toho Chemical Industry Co., Ltd.) as the cationized cellulose and concentrated glycerin as the moisturizing component.
Next, specimens A to E were diluted 100-fold with purified water, 10 mL was weighed, and placed in a centrifuge tube along with 500 mg of wool-derived keratin (trade name: Keratin from wool, manufactured by Tokyo Chemical Industry Co., Ltd.). The centrifuge tube was shaken in warm water at 40 ° C. for 15 minutes at 120 times / minute, and then centrifuged (3500 rpm, 12 minutes). After concentrating the resulting supernatant, concentrated glycerin was quantified by an internal standard method using gas chromatography.
ガスクロマトグラフィーによる測定により、濃グリセリンの調製時からの減少量がケラチンへの濃グリセリン付着量であるとして、下記式によりケラチンへの濃グリセリンの付着率を求めた。なお、各検体について３回ずつ試験を行い、その平均値を付着率とした。
付着率＝［（検体の１００倍希釈時の濃グリセリン濃度×上清の採取量）−ガスクロマトグラフィーによる濃グリセリン検出量］／（検体の１００倍希釈時の濃グリセリン濃度×上清の採取量）×１００ （質量％）
By measuring by gas chromatography, the amount of decrease in concentration of concentrated glycerin from the time of preparation was regarded as the amount of concentration of concentrated glycerin on keratin, and the adhesion rate of concentrated glycerin on keratin was determined by the following formula. The test was performed three times for each specimen, and the average value was defined as the adhesion rate.
Adhesion rate = [(concentrated glycerol concentration at 100-fold dilution of specimen x amount of collected supernatant)-detected amount of concentrated glycerol by gas chromatography] / (concentrated glycerol concentration at 100-fold dilution of specimen x collected amount of supernatant) ) × 100 (mass%)
ケラチンへの濃グリセリン付着率の結果とその標準誤差を表２に示す。 Table 2 shows the result of the concentration ratio of concentrated glycerin to keratin and its standard error.
ポリクオタニウム１０を添加していない検体Ｅの付着率は、１９．１％であったのに対して、検体Ａ〜Ｄではいずれも６０％を超えており、ケラチンに対する濃グリセリンの付着率が大幅に向上することが分かった。このことから、ポリクオタニウム１０が、ケラチンに対する濃グリセリン付着量の増加に寄与していることが明らかとなった。 Sample E to which polyquaternium 10 was not added had an adhesion rate of 19.1%, whereas Samples A to D all exceeded 60%, and the adhesion rate of concentrated glycerin to keratin was greatly increased. It turns out that it improves. From this, it was revealed that polyquaternium 10 contributed to an increase in the amount of concentrated glycerin attached to keratin.
（試験例２：脂肪酸エステル）
保湿成分を濃グリセリンからミスチリン酸イソプロピルに代えた以外は試験例１と同様にして表３に記載した検体Ｆ及びGを調製し、ガスクロマトグラフィーによりケラチンへのミスチリン酸イソプロピルの付着率を求めた。
検体Ｆ及びＧにおけるケラチンへのミスチリン酸イソプロピルの付着率とその標準誤差を表３に示した。なお、オレイン酸ソルビタン及びモノオレイン酸ＰＯＥソルビタンはノニオン系界面活性剤であり、保湿成分であるミスチリン酸イソプロピルを水に溶解させるために使用した。
(Test Example 2: Fatty acid ester)
Samples F and G listed in Table 3 were prepared in the same manner as in Test Example 1 except that the moisturizing component was changed from concentrated glycerin to isopropyl myristate, and the adhesion rate of isopropyl myristate to keratin was determined by gas chromatography. .
Table 3 shows the adhesion rate of isopropyl myristate to keratin and the standard error thereof in specimens F and G. Note that sorbitan oleate and POE sorbitan monooleate are nonionic surfactants and were used to dissolve isopropyl myristylate, which is a moisturizing component, in water.
保湿成分としてミスチリン酸イソプロピルを用いた場合でも濃グリセリンと同様に、ポリクオタニウム１０を添加することによって、ケラチンへの付着率が増加することが分かった。 It has been found that even when isopropyl myristate is used as a moisturizing component, the adhesion rate to keratin is increased by adding polyquaternium 10 as in the case of concentrated glycerin.
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