JP2013234280A - Method for producing hydrogel - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a production method for efficiently and stably obtaining hydrogel, with respect to a method for producing two-liquid mixing type hydrogel.SOLUTION: A plurality of raw material liquids are weighed through respective Moineau pumps 13 or gear pumps so as to give a prescribed weight ratio, and the raw material liquids are poured into a rotary static mixer 11 and mixed by rotating blades 16 built in the rotary static mixer 11. The resulting mixed liquid is discharged from the rotary static mixer 11 into a tray 15.

Description

  The present invention relates to a method for producing a hydrogel that can be used as an external preparation such as cosmetics for packs, a conductive member, a cold storage agent, a coolant, a fixing material, an impact absorber, and the like, and in particular, a two-component mixed hydrogel. Regarding the method.

  Since the two-component mixed hydrogel is difficult to be filled in a desired tray in a state after gelation or to be molded into a desired shape, filling and molding are performed before gelation. However, the two-component mixed hydrogel begins to gel immediately after the start of mixing of the two components, and the viscosity of the mixed solution increases with time. Therefore, from the viewpoint of handleability, it is required to immediately fill and mold after mixing the raw material liquid. As a manufacturing method of hydrogel, Unexamined-Japanese-Patent No. 2001-213725 (patent document 1) has description, for example.

JP 2001-213725 A

That is, if the raw material liquid to be hydrogel is mixed, gelation proceeds even before coating with an applicator or the like, and it is difficult to mix a large amount of raw material liquid at a time and mold it little by little. Further, when mixing a small amount of raw material liquid, it is necessary to frequently wash the mixing tank and replace the raw material liquid, which is troublesome. Furthermore, the degree of mixing and the viscosity of each batch are likely to vary, making it difficult to obtain a uniform and stable hydrogel. Furthermore, mixing in a tray is not preferable because of lack of uniformity.
In addition, if there is dripping or stringing after discharging, there is a risk that the quantitativeness may be lost, and the area around the discharge port may need to be cleaned or the appearance may deteriorate. .
Therefore, the present invention has been studied for the purpose of obtaining a production method for obtaining hydrogel stably and more efficiently.

  In order to achieve the above object, a hydrogel production method obtained by mixing a plurality of raw material liquids is measured by rotating each raw material liquid through a mono pump or gear pump so that the plurality of raw material liquids have a predetermined weight ratio. A hydrogel production method characterized by injecting into a static mixer, rotating blades built in the rotary static mixer to mix the raw material liquid, and discharging the mixed liquid from the rotary static mixer to cause gelation provide.

  Since the raw material liquid is measured through the Mono pump or the gear pump, the raw material liquid can be measured and mixed with high accuracy. Moreover, since the rotary static mixer with which the built-in blade | wing rotates is used, mixing of a raw material liquid can be performed reliably reliably. Such rotary static mixers are disposable and can be easily replaced after use or in the event of trouble, so maintenance is simple and productivity can be improved. Moreover, since the volume can be reduced as compared with a static mixer in which the blades do not rotate, not only the entire equipment is reduced, but also the raw materials are easily sterilized. Therefore, it can be suitably used for the production of a hydrogel for cosmetics that particularly dislikes bacterial contamination. Moreover, the hydrogel can be produced in a short time and discontinuously by the rotation of the blades. On the other hand, the conventional static mixer in which the blades do not rotate has to use a blade having a large number of blades if mixing is sufficiently performed. If the number of blades is increased, the mixing time becomes longer and gelation occurs during mixing, which makes it substantially difficult to use discontinuously. However, since a rotary static mixer with rotating blades is used, a stable and uniform hydrogel can be produced.

A rotary static mixer having 10 to 20 blades and 100 to 5000 revolutions / minute can be used. Since the number of blades of the rotary static mixer is 10 to 20 and the number of rotations is 100 to 5000, it is possible to sufficiently stir and mix the raw material liquid for hydrogel production without causing uneven mixing. .
In addition, a plurality of raw material liquids are injected through a mono pump or gear pump at a low temperature of 4 to 20 ° C. without touching the outside air, discharged from this rotary static mixer, and then heated to 25 to 60 ° C. to promote gelation. Can do.
Since the raw material liquid is mixed without touching the outside air, air can be prevented from being mixed in and a good-looking hydrogel can be manufactured.
Since the raw material liquid is injected into the rotary static mixer at a low temperature of 4 to 20 ° C., the progress of gelation after mixing of the raw material liquid can be suppressed. Therefore, raw materials can be handled with a relatively low viscosity. In addition, the reaction rate can be stabilized in order to suppress heat generation during mixing. And since it heats to 25-60 degreeC after mixing, the gelatinization after mixing can be accelerated | stimulated.

Injecting the plurality of raw material liquids into the rotary static mixer without pressurizing each raw material liquid, and discharging the mixed liquid having a viscosity of 5000 to 50000 cps from a discharge port having a diameter of 10 mm or less provided in the rotary static mixer. Can do.
Since the plurality of raw material liquids are injected into the rotary static mixer without being pressurized for each raw material liquid, the measurement can be accurately performed. Further, since the raw material liquid is mixed after being injected into the rotary static mixer, the mixing conditions can be kept constant. And since the liquid mixture with a viscosity of 5000-50000 cps is discharged from the discharge port with a diameter of 10 mm or less provided in the rotary static mixer, it is possible to prevent dripping and improve the working efficiency.

The mixed liquid can be discharged from the rotary static mixer onto a tray which is a mold for gelling into a predetermined shape and is a container for hydrogel obtained by gelling.
Molding used only for hydrogel molding because the tray that discharges the liquid mixture from the rotary static mixer is a mold that gels the liquid mixture into a predetermined shape and also serves as a container for the hydrogel obtained by gelation. The preparation of the mold is unnecessary, and the manufacturing process can be simplified and the manufacturing cost can be reduced.

  According to the method for producing a hydrogel of the present invention, the mixing efficiency of the raw material liquid for producing the hydrogel can be dramatically increased, and the hydrogel can be produced discontinuously in a short time.

It is a schematic diagram of the apparatus for hydrogel manufacture. 2A is a plan view of the tray, and FIG. 2B is a cross-sectional view taken along the line SA-SA in FIG. 2A. It is a schematic diagram of the blade | wing built in a rotary static mixer. It is a top view of pack cosmetics.

  The manufacturing method of the hydrogel of this invention is demonstrated referring drawings. In addition, when showing a modified example, a changed part shall be demonstrated and duplication description is abbreviate | omitted about a common structure, a material, a manufacturing method, an effect, etc.

  An example of production equipment for producing hydrogel using a rotary static mixer is shown in the schematic view of FIG. 11 is a rotary static mixer, 12 (12a and 12b) is a raw material storage tank, 13 (13a and 13b) is a mono pump, 14 is a motor that rotates blades 16 inside the rotary static mixer 11, 17 is a solenoid valve, and 18 is a discharge valve. An outlet 15 is a tray.

  As the raw material liquid of the two-component mixed hydrogel, the A liquid is stored in a separate storage tank, and the B liquid is stored in a separate storage tank. Details of the liquid A and liquid B will be described later. The temperature of the storage tanks 12a and 12b is preferably 4 ° C to 40 ° C, and more preferably 4 ° C to 20 ° C. Moreover, it is preferable that the raw material liquid viscosity by a B-type viscometer shall be 5000-50000 cps. This is because when the viscosity is set to this level, it can be sent out by the MONO pump 13 and can be suitably dispersed and mixed by the rotary static mixer 11. This is because the properties of the raw material liquid are also stable. On the other hand, if the liquid viscosity exceeds 50000 cps, mixing takes time, and the friction during mixing increases, so heat is generated and the gelation rate is difficult to control. On the other hand, if it is lower than 5000 cps, the liquid is liable to drip.

  The metering and delivery of the raw material liquid are performed by the MONO pumps 13a and 13b. This is because the MONO pump has less pulsation of the raw material liquid and can be measured with an accuracy within ± 2%. Moreover, it is easy to diffuse after discharge to the tray 15, and it is difficult to mix bubbles. A gear pump can also be used as delivery means other than the MONO pump. The electromagnetic valve 17 controls the feed amount precisely by cutting off the pressure from the mono pump, and prevents pressure from being applied when the raw material liquid is introduced into the rotary static mixer 11.

  The rotary static mixer 11 is installed so that the longitudinal direction thereof is in the vertical direction, and the raw material liquid after passing through the electromagnetic valve 17 is dropped into the rotary static mixer 11 without being mixed and not particularly pressurized. Is preferred. Since mixing and discharging are performed only when the blades 16 rotate in the rotary static mixer 11, liquid dripping due to residual pressure is unlikely to occur when rotation stops, and liquid dripping is suppressed by discharging from the discharge port 18 of φ10 or less. can do.

The raw material liquid sent from the MONO pumps 13a and 13b to the rotary static mixer 11 through the electromagnetic valve 17 is effectively stirred and mixed by the blades 16 provided therein while passing through the rotary static mixer 11.
As shown in FIG. 3, the blade 16 has a spiral shape. That is, one blade 16a is formed in a shape in which one end of the flat plate is rotated 180 ° to the right, and another blade 16b is formed in a shape in which one end of the flat plate is rotated 180 ° to the left. . A single blade 16 is formed by connecting a plurality of the combined blades 16b at a position rotated by 90 ° with respect to the previous blade 16a. The length of the one blade 16 is preferably 10 to 20 in terms of the total number of the blades 16a and 16b. If the number of blades is less than 10, poor mixing tends to occur, and if it exceeds 20, the size is increased and the maintenance becomes complicated. Further, it is preferable that the number of blades 16a and the number of blades 16b is the same, and the number of blades 16a and 16b is an even number as a whole. This is because the rotation of the blade 16 does not affect the discharge amount, and the raw material liquid needs to pass through the rotary static mixer 11 with a constant discharge amount controlled by the Mono pump 13. FIG. 3 shows an example in which ten blades 16a and 16b are provided.
The number of rotations of the blade 16 is controlled by the motor 14 and can be set to 100 to 5000 rotations / minute. If the rotational speed is less than 100 revolutions / minute, poor mixing is likely to occur, and the advantage of rotating the blades 16 cannot be obtained. On the other hand, if it exceeds 5000 revolutions / minute, the molecular chain of the raw material polymer may be sheared to change the physical properties.

  The reaction rate of gelation can be adjusted by changing the liquid temperature of the raw material liquid. At low temperatures, gelation becomes slow, and the time until loss of fluidity (pot life) can be extended. Moreover, gelation becomes quick at high temperature, and hardening can be accelerated. For this reason, if the raw material liquid is mixed at a low temperature of 4 ° C. to 20 ° C., the raw material mixed liquid can be injected into the tray 15 with relatively high fluidity, and the raw material mixed liquid can be easily put into the tray 15. Can be diffused. Moreover, the spinnability can be suppressed. Thereafter, when the liquid temperature is raised to 25 ° C. to 60 ° C. using an infrared heater or the like, gelation proceeds rapidly.

The hydrogel includes water in a network structure formed from a hydrophilic polymer before crosslinking and a crosslinking substance. Therefore, the raw material liquid before being injected into the rotary static mixer 11 includes a hydrophilic polymer and a crosslinkable material before crosslinking, but preferably further includes a pH adjuster, a wetting agent, a medicinal component, and the like. Also good.
For example, the liquid A can be a raw material liquid containing a hydrophilic polymer before cross-linking and a cross-linkable substance that causes a cross-linking reaction therewith, and the liquid B can be an acid catalyst that is an aqueous solution of an organic acid or an inorganic acid. Therefore, it is one of the preferred embodiments that the liquid A contains polyacrylic acid Na and magnesium metasilicate aluminate, and the liquid B contains tartaric acid as an acid catalyst. The raw materials for forming such a hydrogel are as follows. This will be explained in detail.

  The hydrophilic polymer is not particularly limited as long as it has a network structure and can form a hydrogel containing at least water, but a hydrophilic polymer having an anionic functional group is preferably used. Examples of such hydrophilic polymers include polymers of polymerizable unsaturated monomers such as acrylic acid and methacrylic acid having a carboxyl group as a functional group, and salts thereof (for example, sodium salt, potassium salt, Triethanolamine salts, etc.), polymers of polymerizable unsaturated monomers such as t-butylacrylamide sulfonic acid having a sulfonic acid group as a functional group, and salts thereof (for example, sodium salts, potassium salts, etc.) It is done.

Examples of the crosslinkable substance include aluminum hydroxide, potassium alum, aluminum sulfate, aluminum glycinate, aluminum acetate, aluminum oxide, aluminum metasilicate, magnesium chloride, calcium hydroxide, calcium carbonate, magnesium aluminate metasilicate, and polyethyleneimine. Polyethylene glycol diglycidyl ether, glycerin triglycidyl ether, triglycidyl isocyanurate and the like.
In addition, various organic acids and inorganic acids such as tartaric acid, lactic acid, citric acid, glycolic acid and hydrochloric acid are used as a pH adjuster for the purpose of adjusting the pH to an optimum value for the action of the crosslinkable substance and ensuring more reliable crosslinking. May be. Specifically, tartaric acid, lactic acid, glycolic acid and the like are particularly preferable.
The hydrophilic polymer before cross-linking may be partially cross-linked as long as the production of the hydrogel is not hindered. In view of handling at the time of production, it is preferable to use a hydrophilic polymer before crosslinking having a weight average molecular weight in the range of 100,000 to 5,000,000.

  Examples of the wetting agent include ethylene glycol, polyethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, polypropylene glycol, dipropylene glycol, glycerin, diglycerin, isopropylene glycol, 1,3-butylene glycol, sorbitol, malbitol, and xylitol. Mannitol, hyaluronic acid and salts thereof, various derivatives such as trehalose and raffinose, glycols such as trimethylglycine and cyclodextrin, polyhydric alcohols and polysaccharides. These are preferably used alone or in admixture of two or more.

  The medicinal ingredients that can be mixed in the hydrogel are not particularly limited as long as they are conventionally used in pharmaceuticals, quasi drugs, cosmetics, hygiene materials, sundries, etc., for example, Ashitaba Extract, Avocado Extract, Achacha Extract, Altea Extract, Arnica Extract, Apricot Extract, Apricot Kernel Extract, Fennel Extract, Turmeric Extract, Oolong Tea Extract, Echinashi Leaf Extract, Ogon Extract, Oat Extract, Barley Extract, Dutch Mustard Extract, Orange Extract, Dry seawater, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, chamomile extract, carrot extract, kawara mugi extract, licorice extract, kiwi extract, kina extract, cucumber extract, guanosine, kumazasa extract, walnut extract Grapefruit extract, Clematis extract, Yeast extract, Burdock extract, Comfrey extract, Collagen, Cowberry extract, Psycho extract, Saitai extract, Salvia extract, Soap extract, Sasa extract, Hawthorn extract, Shiitake extract, Giant extract, Shikon extract, Linden extract, Citrus extract, ginger root extract, birch extract, horsetail extract, honeysuckle extract, Japanese kizuta extract, Atlantic hawthorn extract, elderberry extract, yarrow extract, mint extract, mallow extract, sensu extract, thymus extract, thyme extract, clove extract , Chigaya extract, chimpi extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, wild rose , Hibiscus extract, bacmond extract, parsley extract, honey, parietalia extract, toad extract, bisabolol, dandelion extract, fukinotou extract, bukuryo extract, butcher bloom extract, grape extract, propolis, loofah extract, peppermint extract, bodaiju extract, Hop extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, peach extract, cornflower extract, eucalyptus extract, yuzu extract, mugwort extract, lavender extract, apple extract, lettuce extract, lemon extract, lotus extract, rose extract, rosemary extract, roman Examples include chamomile extract and royal jelly extract.

  In addition, biopolymers such as deoxyribonucleic acid, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membrane; moisturizing ingredients such as amino acids, urea, sodium pyrrolidonecarboxylate, betaine, whey, trimethylglycine; sphingolipids, Oil components such as ceramide, cholesterol, cholesterol derivatives, phospholipids; anti-inflammatory agents such as ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, hydrocortisone; vitamins A, B2, B6, D, E, Vitamins such as calcium pantothenate, biotin, nicotinamide; active ingredients such as allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid; tocopherols, carotenoids Antioxidants such as flavonoids, tannins, lignans and saponins; blood circulation promoters such as γ-oryzanol and vitamin E derivatives; wound healing agents such as retinol and retinol derivatives; cephalanthin, capsicum tincture, hinokitiol, garlic iodide extract, hydrochloric acid Pyridoxine, dl-α-tocopherol, dl-α-tocopherol acetate, nicotinic acid, nicotinic acid derivatives, calcium pantothenate, D-pantothenyl alcohol, acetyl pantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinyl estera Diol, Capronium chloride, Benzalkonium chloride, Diphenhydramine hydrochloride, Takanal, Camphor, Salicylic acid, Nonyl acid vanillylamide, Nonanoic acid vanillylamide, Pyrocto Olamine, glyceryl pentadecanoate, mononitroguaiacol, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormone, cantharis tincture, cyclosporine, hydrocortisone, polyoxyethylene sorbitan monostearate, analgesic, tranquilizer Antihypertensives, antibiotics, antihistamines, antibacterial substances and the like.

  The compounding amount of these medicinal ingredients cannot be defined unconditionally because the amount of the active ingredient varies depending on the material, but generally 0.001 to 50% by mass, preferably 0.05 to 30% by mass with respect to the mass of the hydrogel. Is more preferable.

  As described above, the raw material liquids that start gelation by mixing are prepared in advance, the discharge amount of the Mono pump 13 and the gear pump is determined according to the mixing ratio of the raw material liquids, and directly injected into the rotary static mixer 11 through the electromagnetic valve 17. To do. The raw material liquid sufficiently stirred by the rotary static mixer 11 is discharged to the tray 15.

The tray 15 has a recess 15a for storing the raw material mixture as shown in FIG. 2, for example, and is a resin molded body made of a resin having a fixed shape such as amorphous PET.
The tray 15 is a storage container for storing the hydrogel, and also has a role of a mold for forming the hydrogel into a predetermined shape. Therefore, the raw material mixture discharged from the rotary static mixer to the tray can be gelled in the tray 15 and packaged together with the tray 15 with a resin film or the like to obtain a product such as a cosmetic pack.

The embodiment described above is an example of the present invention and can be modified as appropriate without departing from the spirit of the present invention.
For example, in FIG. 1, two storage tanks 12 a and 12 b are provided and two types of raw material liquids are mixed to obtain a hydrogel, but not limited to two types, three or more types of storage tanks can be provided. When two kinds of medicinal ingredients are included, two sets of A liquid and B liquid are prepared, one set is a gel raw material liquid containing one kind of medicinal ingredients, and the other is a separate set. If the gel raw material liquid contains one kind of medicinal component, four storage tanks may be used.
As another modification, the shape of the blades 16 of the rotary static mixer 11 can also be rotated so that the discharge amount is not affected.

  Furthermore, if the raw material mixed liquid containing another component is discharged from each rotary static mixer using a plurality of rotary static mixers as in the pack cosmetic 21 shown in FIG. 4, it is suitable for each part to be packed. A pack cosmetic 21 having ingredients can be obtained. In this pack cosmetic 21, a gel raw material liquid containing a moisturizing component as a medicinal component is discharged from one rotary static mixer to a portion 22 corresponding to the corner of the eye, and a hot flash corresponding component as a medicinal component is applied to a portion 23 corresponding to the cheek. The gel raw material liquid containing is discharged from another rotary static mixer, and the gel raw material liquid not containing such a medicinal ingredient is discharged from another rotary static mixer to the other portion 24, whereby these gel raw material liquids are gelled. Thus, a pack cosmetic 21 made of hydrogel can be obtained.

Next, the present invention will be further described using experimental examples.
Hydrogel raw materials :
The molded body used for the raw material liquid shown below required for hydrogel manufacture, a tray, and the biomedical electrode coating pad was prepared.

(Polymer liquid A)
4 parts by weight of sodium polyacrylate having a molecular weight of 2 million as a hydrophilic polymer, 1 part by weight of magnesium aluminate metasilicate as a crosslinking agent, 10 parts by weight of dipropylene glycol as a lubricant, and 5 parts of concentrated glycerin Parts by weight, 3 parts by weight of polyethylene glycol 1000, 0.1 parts by weight of methylparaben as a preservative, 0.01 parts by weight of sodium hyaluronate as a medicinal ingredient, and 61.89 parts by weight of water A mixed and stirred raw material solution was prepared.

(Polymer liquid B)
4 parts by weight of sodium polyacrylate having a molecular weight of 2 million as a hydrophilic polymer, 1 part by weight of magnesium aluminate metasilicate as a crosslinking agent, 10 parts by weight of dipropylene glycol as a lubricant, and 5 parts of concentrated glycerin Part by weight, 3 parts by weight of polyethylene glycol 1000, 0.1 part by weight of methylparaben as a preservative, 0.1 part by weight of L-menthol as a cooling component, and 61.8 parts by weight of water A mixed and stirred raw material solution was prepared.

(Polymer liquid C)
It does not contain 5 parts by weight of concentrated glycerin as compared with the polymer liquid A, except that 0.1 parts by weight of royal jelly extract is added instead of 0.01 parts by weight of hyaluronic acid Na as a medicinal component, and 66.8 parts by weight of water is mixed. A polymer liquid C was produced in the same manner as the polymer liquid A.

(Acid solution)
2 parts by weight of tartaric acid and 13 parts by weight of water were added to prepare an acid solution.
(tray)
Amorphous PET having a thickness of 0.3 mm was vacuum-molded to produce a tray having a thickness of 2 mm with two oval recesses having an inner dimension of 25 mm minor axis × 56 mm major axis.

(Molded body used for biomedical electrode coating pad)
A rectangular parallelepiped container having an inner dimension of 34 mm × 38 mm and a thickness of 2 mm and having no lid was molded from PET. In addition, a plate-like body having a width of 34 mm × a length of 38 mm (cross-sectional area of 12.92 cm ² ) and a thickness of 0.7 mm, and the shape of the opening of the through hole penetrating in the thickness direction is an equilateral triangle having a side of 10 mm. the holes 3 × 4 columns (opening area 0.43 cm ^2, the total opening area of 5.19 cm ^2, the aperture ratio of 40%) a plate-like pad body provided molded polypropylene resin.
And the molded object used for the electrode cover pad for biological bodies was produced by pushing the pad main body to the depth center vicinity of a rectangular parallelepiped container.

Production of hydrogel :
Each hydrogel shown in the following Examples 1 to 9 was produced.
<Example 1> The polymer liquid A was put into the storage tank (12a), and the acid liquid was put into the storage tank (12b). The discharge of the MONO pump (13a, 13b) was set so that 15 parts by weight of the acid liquid was mixed with 85 parts by weight of the polymer liquid A, and the rotary static mixer (11) (inner diameter: 10 mm, length: 155 mm, number of blades: 12; Injectable into Select Equipment and Engineering Inc. disposable rotary static mixer).
The rotary static mixer (11) has a blade (16) rotating speed of 3000 rpm, stirred and mixed at 15 ° C, and the discharge rate is 1.0 g / second (discharge time 2 seconds). In (15a), 2.0 g of the raw material mixture was discharged. After 15 minutes, the hydrogel no longer deformed even when the tray (15) was tilted, so it was sealed with an aluminum laminated bag and left at 30 ° C. for 24 hours. The completed hydrogel was colorless and transparent, and the mixing state was good from the appearance.

<Example 2> The amount of discharge of the rotary static mixer (11) is changed to 3.0 g / second (discharge time 0.67 seconds), and 2.0 g of the raw material mixture is placed in one recess (15a) of the tray (15). A hydrogel was prepared in the same manner as in Example 1 except for discharging. The completed hydrogel was colorless and transparent, and the mixing state was good from the appearance.

<Example 3> A hydrogel was produced in the same manner as in Example 1 except that the blades of the rotary static mixer were not rotated. From the rotary static mixer, a desired amount of the raw material mixture was discharged to fill the tray, but the appearance of the separation of the two liquids was observed, and the mixing was insufficient.

<Example 4> The hydrostatic mixer was prepared in the same manner as in Example 1 except that the rotary static mixer was changed to a rotary static mixer having an inner diameter of 13 mm, a length of 197 mm, and 12 blades, and the blades were not rotated. The liquid mixture was discharged from the rotary static mixer in a desired amount to fill the tray, but it was visually observed that the two liquids were separated, and mixing was insufficient.

<Example 5> A hydrogel was produced in the same manner as in Example 1 except that the polymer liquid B was added to the storage tank (12a) instead of the polymer liquid A. The obtained hydrogel was colorless and transparent, and the mixing state was good from the appearance.

<Example 6> A hydrogel was produced in the same manner as in Example 2 except that the polymer liquid B was put in the storage tank (12a) instead of the polymer liquid A. The obtained hydrogel was colorless and transparent, and the mixing state was good from the appearance.

<Example 7> A hydrogel was produced in the same manner as in Example 3 except that the polymer liquid B was put in the storage tank (12a) instead of the polymer liquid A. The liquid mixture was discharged from the rotary static mixer in a desired amount to fill the tray, but it was visually observed that the two liquids were separated, and mixing was insufficient.

<Example 8> A hydrogel was produced in the same manner as in Example 4 except that the polymer liquid B was added to the storage tank (12a) instead of the polymer liquid A. The liquid mixture was discharged from the rotary static mixer in a desired amount to fill the tray, but it was visually observed that the two liquids were separated, and mixing was insufficient.

<Example 9> The raw material liquid was mixed with the rotary static mixer in the same manner as in Example 1 except that the polymer liquid C was put in the storage tank (12a) instead of the polymer liquid A to obtain a mixed liquid. The liquid mixture was discharged to the full depth to the molded object used for the biomedical electrode coating pad. Then, the opening of this rectangular parallelepiped container was wrapped and left to stand at 30 ° C. for 24 hours to solidify the mixed solution. The obtained hydrogel was colorless and transparent, and the mixing state was good from the appearance. Moreover, the biomedical electrode coating pad which hydrogel adhered to the pad main body was obtained.

When the blades (16) of the rotary static mixer (11) are not rotated from Examples 1 to 8, the raw material liquid can be sufficiently mixed even if the length of the rotary static mixer itself is increased to increase the number of blades. could not. On the other hand, when the blade (16) of the rotary static mixer (11) was rotated, sufficient mixing was possible.
Moreover, the rotary static mixer could be used suitably for manufacture of the hydrogel integrated with the resin molding, such as a biomedical electrode covering pad as in Example 9.

DESCRIPTION OF SYMBOLS 11 Rotary static mixer 12 Storage tank 12a, 12b Storage tank 13 Pump 13a, 13b Mono pump 14 Motor 15 Tray 15a Recess 16 Blade 16a, 16b Blade 17 Electromagnetic valve 17a, 17b Electromagnetic valve 18 Discharge port 21 Pack cosmetics 22 Part 23 Part corresponding to cheek 24 Other parts

Claims (4)

In the method for producing a hydrogel obtained by mixing a plurality of raw material liquids,
Each raw material liquid is weighed through a Mono pump or gear pump so that a plurality of raw material liquids have a predetermined weight ratio, and is metered into a rotary static mixer, and 10 to 20 blades incorporated in the rotary static mixer are added to 100 to 5000. A method for producing a hydrogel, wherein the raw material liquid is mixed by rotating at a rate of rotation / minute, and the mixed liquid is discharged from a rotary static mixer to be gelled.   A plurality of raw material liquids are injected into the rotary static mixer at a low temperature of 4 to 20 ° C. without touching the outside air, discharged from the rotary static mixer, and then heated to 25 to 60 ° C. to promote gelation. Item 2. A method for producing a hydrogel according to Item 1.   The plurality of raw material liquids are injected into a rotary static mixer without pressurizing each of the raw material liquids, and the mixed liquid having a viscosity of 5000 to 50000 cps is discharged from a discharge port having a diameter of 10 mm or less provided in the rotary static mixer. The manufacturing method of the hydrogel of Claim 1 or Claim 2.   4. Any one of claims 1 to 3, wherein the mixed liquid is a mold that gels into a predetermined shape, and is discharged from the rotary static mixer onto a tray that is a container for hydrogel obtained by gelation. The manufacturing method of the hydrogel of description.

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