JP2010197136A - Measuring instrument - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To efficiently collect a minute substance contained in the atmosphere when the concentration of an antigen contained in the atmosphere is measured or estimated. <P>SOLUTION: When a measuring chip 8 is inserted in the opening part of a measuring instrument 3, the control part 31 of the measuring instrument 3 operates a drive part 34 to drive the pressurizing part opposed to the suction pump provided to the measuring chip 8. The capacity of the suction pump is varied by driving the pressurizing part and the air stream going toward an adsorbing chamber from a suction port is produced. Since a revolving blade is rotated by accompanying the produced air stream, the gas in the adsorbing chamber is revolved. The revolved gas impinges against the adsorbing surface of the adsorbing chamber to be discharged from a discharge port. The control part 31 allows the suction pump to perform this operation and the suction pump to stop after the elapse of a predetermined time. By this constitution, the particles contained in the sucked atmosphere are adsorbed by the adsorbing surface provided to the bottom of the adsorbing chamber. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a technique of a measuring apparatus that performs measurement related to the concentration of an allergen causing substance.

The number of patients with allergies, including hay fever, is increasing every year. In order to appropriately prevent the development of allergies, it is effective to measure how much the antigen that causes allergies is contained in the atmosphere. For example, when a high concentration of antigen is measured in the atmosphere, an allergic patient or the like prevents the development of allergy by wearing a mask or the like so as not to contact the antigen. By the way, in general, pollen forecasts often give warnings for a very wide range based on data at a specific measurement point. However, since local factors such as airflow conditions in the atmosphere influence, the actual amount of pollen around the patient may deviate from the pollen forecast. In order to prevent the onset of allergy, the concentration of the antigen in the vicinity of the patient must be accurately measured. Therefore, a measuring device that measures the concentration of the surrounding antigen is required. As a technique of such a measuring apparatus, Patent Document 1 describes a measuring apparatus using a detection chip that detects allergen protein by extracting allergen protein from a particle taken in from an external environment into a carrier liquid. ing.

JP 2005-69997 A

However, in the technique described in Patent Document 1, cedar pollen is collected by natural dropping into the upper opening of the extraction unit or simple suction (see paragraph 0061). If you wait for a natural fall, you cannot measure with sufficient accuracy for preventive measures unless you wait for a relatively long measurement period. In addition, when collecting by simple suction, pollen does not stay in the collecting part, but the amount of pollen that accompanies the airflow and passes outside is large, and measurement cannot be performed with sufficient accuracy.
Accordingly, an object of the present invention is to efficiently collect minute substances contained in the atmosphere when measuring or estimating the antigen concentration in the atmosphere.

  In order to solve the above-described problems, a measurement apparatus according to the present invention includes a suction unit that sucks air, an adsorption member that is provided in a flow path through which the air sucked by the suction means flows, and the adsorption device in the flow path. A swiveling unit that is provided upstream of the member and that swirls the atmosphere sucked by the sucking unit; a solvent is supplied; and an adsorbed object adsorbed by the adsorbing member is dispersed in the solvent and is predetermined. It is characterized by comprising conveying means for conveying to a position and measuring means for measuring the adsorbed object conveyed to the position by the conveying means.

  The measuring device according to the present invention includes a swiveling unit that sucks and swirls the atmosphere, and an adsorption member provided downstream of the swirl unit in a flow path through which the air swirled by the swirl unit flows. A supply means for supplying a solvent, and an adsorbate adsorbed by the adsorbing member is dispersed in the solvent and conveyed to a predetermined position; and the adsorbed object conveyed to the position by the conveyance means And measuring means for measuring an object.

Preferably, the suction means includes: an airflow generating unit that generates a flow in the atmosphere by receiving a first driving force; and a first driving force applying unit that applies the first driving force to the airflow generating unit. And the conveying means receives a second driving force to generate a flow in the solvent in which the adsorbent is dispersed, and the second driving force to the solvent flow generating unit. And the adsorbing member, the swiveling means, the airflow generating section, and the solvent flow generating section are provided in a microchip, and the measuring means and the first driving force applying section are provided. And the second driving force application unit are provided in a measuring instrument having a mounting part for mounting the microchip, and the first driving force is mounted in a state where the microchip is mounted on the mounting part of the measuring instrument. The imparting unit provides the first driving force. The air flow generation unit causes a flow in the atmosphere, and the second driving force application unit applies the second driving force, so that the solvent flow generation unit generates a flow in the solvent, The measurement means may measure the adsorbed object conveyed to the position.

Preferably, the swirl means receives a first driving force to generate a swirling flow generating portion that generates a swirling flow in the atmosphere, and a first driving that applies the first driving force to the swirling flow generating portion. A force applying unit, and the conveying means receives a second driving force to generate a flow in the solvent in which the adsorbed material is dispersed, and the second driving force. A second driving force applying unit that applies to the solvent flow generation unit, and the adsorption member, the swirl flow generation unit, and the solvent flow generation unit are provided in a microchip, and the measurement unit and the first drive The force applying unit and the second driving force applying unit are provided in a measuring instrument having a mounting unit for mounting the microchip, and the first chip is mounted in the mounting unit of the measuring instrument. A driving force application unit applies the first driving force. Thus, the swirl flow generating unit generates a swirl flow in the atmosphere, and the second driving force applying unit applies the second driving force, whereby the solvent flow generating unit generates a flow in the solvent. The measuring means may measure the object to be adsorbed conveyed to the position.

  According to the present invention, when measuring or estimating the antigen concentration in the atmosphere, it is possible to efficiently collect minute substances contained in the atmosphere.

1 is an external view showing an antigen measurement system according to the present invention. It is a block diagram showing the whole structure of an antigen measurement system. It is an external view showing the measurement chip. FIG. 4 is a cross-sectional view taken along line IV-IV in FIG. 3. FIG. 5 is a cross-sectional view taken along line VV in FIG. 3. FIG. 6 is a cross-sectional view taken along line VI-VI in FIG. 4. FIG. 7 is a sectional view taken along line VII-VII in FIG. 4.

1. Configuration 1-1. Overall Configuration FIG. 1 is an external view showing an antigen measurement system 9 according to the present invention. The antigen measurement system 9 includes a measurement device 3 and a measurement chip 8. The user inserts the measuring chip 8 into the opening 30 of the measuring device 3 and measures the antigen. When the measurement chip 8 is inserted into the opening 30, a suction port 20 (described later) provided in the measurement chip 8 is in contact with the external space, and the detection unit 16 (described later) is the housing of the measuring instrument 3. The measurement chip 8 is configured to be fixed in a state where it is covered with. The measuring device 3 includes a display unit 32 that displays a measurement result and an operation unit 33 that accepts an operation on the measuring device 3 by a user. The display unit 32 is a display unit that displays measurement values by a 7-segment display, a dot matrix display, or the like. The operation unit 33 includes operation buttons for inputting various instructions, and accepts an operation by a user and supplies a signal corresponding to the operation content. In this embodiment, the housing of the measuring device 3 is a rectangular parallelepiped of 110 mm × 50 mm × 20 mm, and the measuring chip 8 is a plate-like body of 20 mm × 5 mm × 0.5 mm, but these sizes are various. Can be designed to.

  FIG. 2 is a block diagram showing the overall configuration of the antigen measurement system 9. The figure shows that the measurement by the antigen measurement system 9 is performed in a state where the measurement chip 8 is inserted into the measuring instrument 3. The measuring instrument 3 includes a control unit 31, a drive unit 34, a measurement unit 35, and an electric field generation unit 36 in addition to the display unit 32 and the operation unit 33 described above. The control unit 31 includes a central processing unit (CPU) that is a control circuit, and storage devices such as a ROM (Read Only Memory), a RAM (Random Access Memory), and an EEPROM (Electrically Erasable Programmable Read Only Memory). The CPU of the control unit 31 controls each unit of the measuring instrument 3 by reading and executing a boot loader stored in the ROM and a computer program stored in the EEPROM.

  The drive unit 34 is a device that is controlled by the control unit 31 and mechanically presses the measurement chip 8 inserted into the opening 30 of the measuring device 3. Various driving sources for generating the pressing force can be used. For example, the member to be pressed has a bag shape made of an elastic body such as rubber, and the pressing force is generated by changing the shape of the member depending on the amount of air injected into the internal cavity of the member. Further, the pressing force may be generated by an electromagnetic mechanism such as a solenoid.

  The measurement unit 35 is controlled by the control unit 31 and measures the amount of particles collected by the measurement chip 8. Various types of measurement can be used for the measurement by the measurement unit 35. Here, the absorbance of light irradiated on the measurement chip 8 is measured. Specifically, the measurement unit 35 includes an LED (Light Emitting Diode) 351 and an optical sensor 352, and the LED 351 emits light toward the detection unit 16 of the measurement chip 8 and passes through the detection unit 16. By detecting the light with the optical sensor 352, the absorbance of the irradiated light is measured. The electric field generator 36 is controlled by the controller 31 and generates a potential difference between the anode 141 and the cathode 142 of the measurement chip 8 via a terminal (not shown), thereby orthogonally separating the measurement chip 8 from the orthogonal type. Actuate section 14.

1-2. Configuration of Measuring Chip FIG. 3 is an external view showing the measuring chip 8. The measurement chip 8 has a structure in which two plates formed by molding a transparent resin or the like are overlapped. As shown in FIG. 3A, there is a chip substrate layer 1 on the lower side, and a chip suction layer 2 is laminated on the chip substrate layer 1 in an overlapping manner. A suction port 20 is provided on the upper surface of the chip suction layer 2. A discharge port 23 is provided on the side surface side of the chip suction layer 2. The measuring chip 8 sucks air from the suction port 20 and discharges it from the discharge port 23. Particles carried along with the atmosphere are collected inside the measurement chip 8. FIG. 3B shows the measurement chip 8 as viewed from the side surface with the discharge port 23. The IV-IV line and VV line shown in FIG. 4 and the observation direction of the cross-sectional views of FIG.

1-3. Configuration of Chip Substrate Layer FIG. 4 is a cross-sectional view taken along line IV-IV in FIG. That is, FIG. 4 shows a cross section of the chip substrate layer 1. The solvent tank 11 shown in the figure is a 2 mm × 2 mm × 0.25 mm cavity and has a capacity of 1 μL. Distilled water is enclosed in the solvent tank 11 as a solvent for conveying particles. The solvent supply path 181 is a tube made of an elastic body such as rubber, and is closed when pressed by a pressing portion (not shown) driven by the driving unit 34 of the measuring instrument 3. And when this press part stops pressing, the solvent supply path 181 will be restored | restored by the elastic force of rubber | gum itself, and will open. That is, the solvent supply path 181 functions as an on-off valve that closes when pressed by the drive unit 34 of the measuring device 3.

  The solvent supply pump 12 has a cylindrical space, and the ceiling surface and the bottom surface facing each other are both made of an elastic body such as rubber. The periphery of the ceiling surface and the periphery of the bottom surface are fixed. When the solvent supply path 181 is open, the ceiling surface or the bottom surface is pressed by a pressing portion (not shown) that is driven by the driving unit 34 of the measuring device 3, thereby the center portion of the ceiling surface is The central portion of the bottom surface approaches or moves away, and as a result, the capacity of the internal space of the solvent supply pump 12 changes. As a result, the pressure in the internal space of the solvent supply pump 12 becomes negative as compared with the solvent tank 11, and the solvent supply pump 12 conveys the solvent sealed in the solvent tank 11 to the adsorption chamber 13. That is, the solvent supply pump 12 is pressed by the drive unit 34 of the measuring device 3 and functions as a diaphragm pump. In addition, although the supply speed | rate of the solvent at this time can be set to various values, in this embodiment, it is about 0.005 microliter / s.

The suction chamber 13 is a cylindrical space provided immediately below the suction port 20 provided in the chip suction layer 2 described above. Since the suction chamber 13 has a diameter of 1 mm and a depth of 50 μm, the capacity of the suction chamber 13 is about 0.039 μL. The adsorption chamber 13 has an adsorption surface at the bottom for adsorbing particles contained in the atmosphere. That is, this adsorption surface is an example of an adsorption member provided in a flow path through which the air sucked by the suction means flows. The particles adsorbed on the adsorption surface are dissolved or dispersed by the solvent (here, distilled water) supplied from the solvent tank 11 to the adsorption chamber 13 by the solvent supply pump 12. The solution discharge path 182 functions as an on-off valve, like the solvent supply path 181, and when this is opened, the solution filled in the adsorption chamber 13 is supplied to the orthogonal electrophoresis separation unit 14.

  The orthogonal electrophoresis separation unit 14 is a flow path having a function of concentrating particles by applying an electric field in a direction orthogonal to the direction in which the solution passes. The solution discharged from the solution discharge path 182 is supplied to the electrophoresis region 143 and flows to the right in FIG. The anode 141 and the cathode 142 are arranged so as to generate an electric field in a direction orthogonal to this flow. Each of the anode 141 and the cathode 142 has a terminal (not shown). When the measuring chip 8 is inserted into the opening 30 of the measuring instrument 3, each terminal is connected to the electric field generator 36 of the measuring instrument 3. Connecting. Thereby, an electric field is generated between the anode 141 and the cathode 142 in accordance with the potential difference generated in the electric field generating unit 36 under the control of the control unit 31 of the measuring instrument 3, and particles in the solution passing through the electrophoresis region 143. Electrophorese under the influence of this electric field. In this embodiment, since the particles are negatively charged, the particles in the solution move (electrophoresis) so as to approach the anode 141. That is, the particles in the solution are concentrated on the anode 141 side.

  The liquid feed pump 150 functions as a diaphragm pump, like the solvent supply pump 12, and transports the solvent that has passed through the anode-side separation flow path 144 to the detection unit 16 via the liquid feed path 183. The detection unit 16 is a space in which the concentration of particles is measured by the measurement unit 35 of the measuring device 3. The detection unit 16 is surrounded by glass or resin that transmits light, irradiated with irradiation light by the measurement unit 35 of the measuring instrument 3, and the intensity of the transmitted light transmitted through the detection unit 16 is measured. Absorbance is calculated based on the intensity of the transmitted light and the intensity of irradiation light, and the particle concentration in the solution conveyed to the detection unit 16 is measured based on the calculated absorbance.

  Similar to the solvent supply pump 12, the first waste liquid pump 151 also functions as a diaphragm pump. When the first waste liquid passage 184 is opened and the first waste liquid pump 151 is driven, the solution filled in the detection unit 16 is sent to the waste liquid tank 17. The second waste liquid pump 152 also functions as a diaphragm pump, like the solvent supply pump 12. When the second waste liquid path 185 is opened and the second waste liquid pump 152 is driven, the solution filled in the cathode side separation flow path 145 is sent to the waste liquid tank 17.

1-4. Configuration of Tip Suction Layer FIG. 5 is a cross-sectional view taken along line VV in FIG. That is, FIG. 5 shows a cross-sectional view of the chip suction layer 2. As described above, the swirl vane 21 is provided in the chip substrate layer 1 directly below the suction port 20 of the chip sucking layer 2, and the suction chamber 13 is provided in the chip substrate layer 1 below the swirl vane 21. Is provided. A flow path leading from the adsorption chamber 13 to the discharge port 23 is provided.

The suction pump 22 is provided between the channels from the adsorption chamber 13 to the discharge port 23. This suction pump 22 functions as a diaphragm pump, like the solvent supply pump 12. As the suction pump 22 discharges the gas inside the adsorption chamber 13 toward the discharge port 23, the inside of the adsorption chamber 13 becomes a negative pressure from the ambient air in the vicinity of the suction port 20. An airflow flowing to In addition, although the flow velocity of this airflow can be designed to various values, in this embodiment, it is 1 to 10 L / min. The suction pump 22 is an example of an airflow generation unit that generates a flow in the atmosphere by receiving a first driving force, and presses the driving unit 34 and the ceiling surface or bottom surface of the suction pump 22. The pressing unit is an example of a first driving force application unit that applies a first driving force to the airflow generation unit. And a 1st driving force provision part and an airflow generation part are contained in the suction means which attracts | sucks air | atmosphere.

As described above, the tip suction layer 2 is provided with the swirl vane 21 between the suction port 20 and the suction chamber 13. The swirl vane 21 includes a shaft fixed by at least one of the chip suction layer 2 and the chip substrate layer 1, and a fan attached to be rotatable about the shaft. The fan has a plurality of blades, and each blade is neither perpendicular nor parallel to the axial direction and is inclined at a predetermined angle. Thereby, when the airflow which goes to the adsorption | suction chamber 13 from the suction opening 20 generate | occur | produces, since the turning blade 21 rotates in connection with this, the generated airflow is swirled. In the flow path of the air flow generated by the suction pump 22, the swirl vane 21 is provided upstream from the adsorption surface of the adsorption chamber 13. Hit. That is, the swirl vane 21 is an example of a swirl unit that is provided upstream of the adsorption member in the air flow path and swirls the atmosphere sucked by the suction unit.

2. Operation The operation of the antigen measurement system 9 according to the present invention will be described. The operation of the antigen measurement system 9 is mainly composed of five steps of “aspiration process”, “dissolution process”, “transport process”, “measurement process”, and “discharge process”. Below, each process is demonstrated using figures. 6 is a cross-sectional view taken along line VI-VI in FIG. 7 is a cross-sectional view taken along line VII-VII in FIG.

2-1. Operation of Suction Process First, when the measurement chip 8 is inserted into the opening 30 of the measuring device 3, the control unit 31 of the measuring device 3 causes the drive unit 34 to close the solvent supply path 181 and the solution discharge path 182. Drive. When the solvent supply path 181 and the solution discharge path 182 are closed, the control unit 31 drives a pressing unit (not shown) facing the suction pump 22 by the driving unit 34. Thereby, the capacity | capacitance of the suction pump 22 fluctuates and the airflow which goes to the adsorption | suction chamber 13 from the suction opening 20 generate | occur | produces. Since the swirl vane 21 rotates with the generated airflow, the gas inside the adsorption chamber 13 swirls. The swirled gas hits the adsorption surface of the adsorption chamber 13 and is then discharged from the discharge port 23. The control unit 31 causes the suction pump 22 to perform this operation, and stops the suction pump 22 when a predetermined time has elapsed. As a result, particles contained in the sucked air are adsorbed on the adsorption surface provided at the bottom of the adsorption chamber 13. The above is the operation of the suction process.

2-2. Next, the control unit 31 drives the drive unit 34 so that the solvent supply path 181 is opened and the solution discharge path 182 is kept closed. When the solvent supply path 181 is opened, the control unit 31 drives the drive unit 34 to move the pressing unit 341 (shown in FIG. 6) disposed at a position facing the solvent supply pump 12, thereby causing the solvent supply pump 12 to move. Operate. The solvent sealed in the solvent tank 11 flows into the adsorption chamber 13 through the solvent supply path 181 by the solvent supply pump 12. Then, the solvent that has flowed in disperses the particles adsorbed on the adsorption surface of the adsorption chamber 13 and becomes a solution having a uniform particle concentration. The above is the operation of the melting process.

2-3. Next, the controller 31 closes the solvent supply path 181, the first waste liquid path 184, and the second waste liquid path 185, and opens the solution discharge path 182 and the liquid supply path 183. The drive unit 34 is driven. Subsequently, the control unit 31 drives the liquid feeding pump 150 by driving the driving unit 34 and moving a pressing unit 343 (shown in FIG. 7) disposed at a position facing the liquid feeding pump 150. As a result, the liquid feed pump 150 transports the solution filled in the adsorption chamber 13 to the electrophoresis region 143. That is, the solvent supply pump 12 and the liquid feed pump 150 are an example of a solvent flow generation unit that generates a flow in the solvent in which the particles adsorbed in the adsorption chamber 13 are dispersed by receiving the second driving force. . Moreover, said press part 341 and the press part 343 are examples of the 2nd driving force provision part which gives a 2nd driving force to a solvent flow generation | occurrence | production part. The second driving force applying unit and the solvent flow generating unit are included in a transport unit that supplies the solvent, disperses the adsorbed material adsorbed by the adsorbing member in the solvent, and transports the adsorbed material to a predetermined position.

  In addition, the control unit 31 controls the electric field generation unit 36 to give a potential difference to the anode 141 and the cathode 142. Thereby, an electric field is generated in the electrophoresis region 143, and particles in the solution are concentrated on the anode 141 side. At this time, the control unit 31 adjusts the operating speed of the liquid feeding pump 150 so that the particles in the solution are sufficiently moved by electrophoresis. Therefore, all the particles are concentrated on the anode 141 side. The And the control part 31 stops this, after continuing operating the liquid feeding pump 150 over predetermined time. Thereby, the detection unit 16 is filled with the solution containing particles. The above is the operation of the transport process.

2-4. Operation of Measurement Step Next, the control unit 31 drives the drive unit 34 so that the solution discharge path 182 and the liquid supply path 183 are closed. Subsequently, the control unit 31 controls the LED 351 provided in the measurement unit 35 to irradiate light toward the detection unit 16 of the measurement chip 8. Then, the control unit 31 controls the optical sensor 352 to detect light transmitted through the detection unit 16. The optical sensor 352 outputs a signal corresponding to the detected transmitted light to the control unit 31, and the control unit 31 receives a predetermined value according to the light amount of the LED 351 and a signal corresponding to the transmitted light output by the optical sensor 352. Based on the indicated value, the absorbance of the irradiated light is measured. The control unit 31 calculates the particle concentration according to the Lambert-Beer law based on the measured absorbance and a predetermined absorption coefficient. Then, the calculated particle concentration is displayed on the display unit 32. The particle concentration may be calculated using a predetermined value such as the ratio of particles adsorbed on the adsorption surface of the adsorption chamber 13 or the ratio concentrated by electrophoresis. The above is the operation of the measurement process.

2-5. Operation of Discharge Process Next, the control unit 31 drives the drive unit 34 so that the first waste liquid path 184 and the second waste liquid path 185 are opened. Subsequently, the control unit 31 operates the first waste liquid pump 151 by driving the drive unit 34 and moving a pressing unit 344 (shown in FIG. 7) disposed at a position facing the first waste liquid pump 151. . Thereby, the first waste liquid pump 151 conveys the solution filled in the detection unit 16 to the waste liquid tank 17. Further, the control unit 31 operates the second waste liquid pump 152 by driving the driving unit 34 and moving a pressing unit 342 (shown in FIG. 6) disposed at a position facing the second waste liquid pump 152. As a result, the second waste liquid pump 1
52 transports the remaining solution from the electrophoresis region 143 to the cathode side separation channel 145 to the waste liquid tank 17. And the control part 31 stops these, after continuing operating the 1st waste liquid pump 151 and the 2nd waste liquid pump 152 over predetermined time. As a result, the solution remaining in the detection unit 16, the electrophoresis region 143, and the cathode-side separation channel 145 is transferred to the waste liquid tank 17. The above is the operation of the discharging process.

  As described above, since the atmosphere is swirled and sucked into the adsorption chamber 13 of the measuring chip 8, the particles in the atmosphere contact the adsorption surface of the adsorption chamber 13 as compared with the case where the swirl blade 21 is not provided. Increase the frequency of As a result, the rate at which the particles pass without being adsorbed on the adsorption surface is reduced, and the particles are collected more efficiently than the conventional measurement chip. Thereby, the measurement precision of an antigen improves.

3. Modification The above is the description of the embodiment, but the contents of this embodiment can be modified as follows. Further, the following modifications may be combined.
3-1. Modification 1
In the above-described embodiment, the control unit 31 of the measuring instrument 3 drives the drive unit 34 and operates the suction pump 22 to generate an air flow from the suction port 20 toward the adsorption chamber 13. The swirl vane 21 provided between the mouth 20 and the adsorption chamber 13 was rotated along with the air flow generated by the suction pump 22 and swirled the air flow. However, the airflow may be generated by the rotation of the swirl vane 21 itself.

  In this case, the suction pump 22 is not necessary for the measuring chip 8. Moreover, the swirl | wing blade 21 should just have a mechanism which rotates itself. As this mechanism, for example, an optically driven actuator that rotates when receiving light may be used. Specifically, it is as follows. That is, when light is applied to a predetermined position of the swirl vane 21, the swirl vane 21 is captured by the reaction of the change in the momentum of light that occurs when the light is refracted and reflected. And the swirl | wing 21 is moved by moving the light which caught the swirl | wing 21. The measuring device 3 is provided with an irradiation unit that irradiates a laser beam toward the position of the swirl vane 21 described above. The swirl vane 21 is rotated by capturing the swirl vane 21 with the laser light emitted by the irradiation unit and rotating the laser beam under the control of the control unit 31. When the swirl vane 21 rotates, the air around the fan of the swirl vane 21 moves with the fan. Since this fan is inclined with respect to the axial direction of the swirl vane 21, the moving ambient air flows from the suction port 20 to the suction chamber 13 while being swirled, and is discharged from the discharge port 23.

  As a result, the swirl vane 21 sucks the ambient air with all of the plurality of vanes provided in the fan, so that variation due to the location of the suction force can be reduced as compared with the case where the suction pump 22 is used. In this modification, the optically driven actuator is used to rotate the swirl vane 21, but another power source may be used. For example, the swirl vanes 21 may be rotated using an electric motor or an ultrasonic motor.

3-2. Modification 2
In the above-described embodiment, the concentration of the particle itself conveyed to the detection unit 16 of the measurement chip 8 is measured based on the absorbance, but the concentration of the antigen contained in the particle may be measured. In this case, the concentration of the antigen may be measured by injecting an antibody that reacts with the antigen into the detection unit 16 and causing an antigen-antibody reaction with the antigen contained in the particles.

DESCRIPTION OF SYMBOLS 1 ... Chip substrate layer, 11 ... Solvent tank, 12 ... Solvent supply pump, 13 ... Adsorption chamber, 14 ... Orthogonal electrophoresis separation part, 141 ... Anode, 142 ... Cathode, 143 ... Electrophoresis region, 144 ... Anode side separation Flow path, 145 ... cathode side separation flow path, 150 ... liquid feed pump, 151 ... first waste liquid pump, 152 ... second waste liquid pump, 16 ... detection part, 17 ... waste liquid tank, 181 ... solvent supply path, 182 ... solution Discharge path, 183 ... liquid feed path, 184 ... first waste liquid path, 185 ... second waste liquid path, 2 ... tip suction layer, 20 ... suction port, 21 ... swirl vane, 22 ... suction pump, 23 ... discharge port, 3 DESCRIPTION OF SYMBOLS 30 ... Opening part, 31 ... Control part, 32 ... Display part, 33 ... Operation part, 34 ... Drive part, 35 ... Measurement part, 352 ... Optical sensor, 36 ... Electric field generation part, 8 ... Measurement chip , 9 ... Antigen measurement system.

Claims (4)

A suction means for sucking air;
An adsorbing member provided in a flow path through which the air sucked by the suction means flows;
A swivel means that is provided upstream of the adsorption member in the flow path and swirls the atmosphere sucked by the suction means;
Conveying means for supplying a solvent, and dispersing the adsorbed object adsorbed by the adsorbing member in the solvent and conveying it to a predetermined position;
And a measuring means for measuring the adsorbed object conveyed to the position by the conveying means. Swirling means for sucking the atmosphere and swirling;
In a flow path through which the air swirled by the swirling means flows, an adsorbing member provided downstream of the swirling means,
Conveying means for supplying a solvent, and dispersing the adsorbed object adsorbed by the adsorbing member in the solvent and conveying it to a predetermined position;
And a measuring means for measuring the adsorbed object conveyed to the position by the conveying means. The suction means includes an airflow generation unit that generates a flow in the atmosphere by receiving a first driving force, and a first driving force application unit that applies the first driving force to the airflow generation unit,
The conveying means receives a second driving force, generates a flow in the solvent in which the adsorbed material is dispersed, and a second driving force is applied to the solvent flow generating unit. 2 driving force application unit,
The adsorbing member, the swivel means, the airflow generation unit, and the solvent flow generation unit are provided in a microchip,
The measuring means, the first driving force applying unit, and the second driving force applying unit are provided in a measuring instrument having a mounting unit for mounting the microchip,
In a state where the microchip is mounted on the mounting portion of the measuring device, the first driving force application unit applies the first driving force, so that the air flow generation unit generates a flow in the atmosphere, When the second driving force application unit applies the second driving force, the solvent flow generation unit generates a flow in the solvent, and the measurement unit measures the adsorbed material transported to the position. The measuring apparatus according to claim 1. The swirling means includes a swirling flow generating section that generates a swirling flow in the atmosphere by receiving a first driving force, and a first driving force applying section that applies the first driving force to the swirling flow generating section. Have
The conveying means receives a second driving force, generates a flow in the solvent in which the adsorbed material is dispersed, and a second driving force is applied to the solvent flow generating unit. 2 driving force application unit,
The adsorbing member, the swirl flow generation unit, and the solvent flow generation unit are provided in a microchip,
The measuring means, the first driving force applying unit, and the second driving force applying unit are provided in a measuring instrument having a mounting unit for mounting the microchip,
With the microchip mounted on the mounting portion of the measuring instrument, the first driving force applying unit applies the first driving force, so that the swirling flow generating unit generates a swirling flow in the atmosphere. When the second driving force application unit applies the second driving force, the solvent flow generation unit generates a flow in the solvent, and the measuring unit moves the adsorbed material transported to the position. The measuring device according to claim 2, wherein the measuring device is measured.

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