JP2009256253A - Microsphere for cosmetic and cosmetic containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide microspheres which are stable even in the components of cleansing preparations and in the components of cleansing preparations, are also stable under make-up operations such as abrasion, and are means for transporting an active ingredient into skin. <P>SOLUTION: Provided are microspheres for cosmetics, which are vesicles having lipid double membrane structure outer shells comprising bis(N-lauroylglutamyl)lysine, and ceramide and/or sterol as the transportation means. The sterol is preferably cholesterol and/or phytosterol. In addition, it is preferable to contain an active ingredient selected from the group consisting of ε,γ-glutamyl lysine, Coptis japonica extract, Achillea sibirica extract, Hypericum erectum extract, Eugenia aromatica extract, ursolic acid compounds, Citrus poonensis extract and sphingoglycolipid, in the microspheres for the cosmetics. In addition, provided is a cosmetic containing the microspheres for the cosmetic. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a microsphere useful for cosmetics and a cosmetic containing the same.

  Cleansing cosmetics and aqueous detergents have the function of dispersing the dirt adhering to the skin in the dispersion medium and using the surface active ability of the cosmetics. If the dispersion medium is a cleansing cosmetic, it is an oil phase contained in the cleansing cosmetic, and the aqueous cleaning liquid is a liquid used for cleaning such as warm water. Since all of these cosmetics have a high surface-active ability of the cosmetic composition itself, when an active ingredient is included, the cosmetic composition is often retained in the cosmetic and the orientation to the skin is often inhibited. . Moreover, in order to improve such orientation to the skin, a transport medium such as a liposome is used (see, for example, Patent Document 1). However, there were not a few cases where the intended effect could not be obtained. On the other hand, cleansing and cleaning involve physical treatment such as rubbing in order to disperse dirt in the medium, so that the collapse of the transport medium due to such physical treatment is also a negative factor. That is, it has been desired to develop a means for reliably orienting the active ingredient to the skin even under the prescription constitution and usage mode such as cleansing and cleaning materials.

  Bis (N-lauroylglutamyl) lysine has been known to contain bathing agents and detergents as a moisturizing agent or surfactant (see, for example, Patent Document 2), but there is also a property of forming vesicles. In addition, the vesicles containing such components are stable among cleansing and cleansing formulation components, and are stable in cosmetic operations such as scratching, while being excellent in the transportability of active ingredients into the skin. Was not known at all.

  On the other hand, it is already known that ceramide or phytosterol is used together with phospholipids for the preparation of liposomes (see, for example, Patent Document 3 and Patent Document 4), but a technique for processing into vesicles together with bis (N-lauroylglutamyl) lysine. Is not known at all, and the vesicles containing such ingredients are stable among cleansing and cleansing ingredients, and are also effective for cosmetic action such as abrasion, but are active ingredients in the skin. It was not known at all that it was excellent in transportability.

JP 2003-238378 A JP 2007-191463 A JP 2006-328026 A Japanese Patent Laid-Open No. 08-40823

  The present invention has been made under such circumstances, and it is stable among cleansing preparation ingredients and cleaning preparation ingredients, and is also effective for cosmetic operations such as abrasion, and into the skin. It is an object to provide a means of transportation.

In view of such a situation, the present inventors have transported an active ingredient into the skin that is stable among cleansing and cleaning ingredients, and is also stable in cosmetic operations such as scratching. As a result of intensive research efforts to find a means, it is a small sphere to be blended in cosmetics with high surface activity, and it contains bis (N-lauroylglutamyl) lysine and ceramide and / or sterol. The inventors have found that a vesicle having an outer shell having a multilayer structure is a transport carrier having such characteristics, and has completed the invention. That is, the present invention is as follows.
<1> A vesicle having a lipid bilayer structure outer shell containing bis (N-lauroylglutamyl) lysine and ceramide and / or sterol, which is a spherule to be incorporated into a cosmetic having high surface activity. A cosmetic sphere characterized by being.
<2> The cosmetic spherule according to <1>, wherein the sterol is cholesterol and / or phytosterol.
<3> containing an active ingredient selected from the group consisting of ε, γ-glutamyllysine, auren extract, yarrow extract, hypericum extract, clove extract, ursolic acid, poncan extract and glycosphingolipid. The cosmetic microsphere according to <1> or <2>, which is characterized.
<4> The cosmetic microsphere according to any one of <1> to <3>, wherein the cosmetic having high surface activity is a cleansing cosmetic or an aqueous detergent.
<5> A cosmetic comprising the cosmetic microsphere according to any one of <1> to <4>.
<6> The cosmetic according to <5>, wherein the cosmetic is a cleansing cosmetic or an aqueous cleaning material.

  According to the present invention, it is possible to provide a means for transporting an active ingredient into the skin, which is stable among cleansing preparation ingredients and cleaning preparation ingredients, and is also stable in cosmetic operations such as scratching.

(1) Vesicles of the present invention The vesicles of the present invention are small spheres for cosmetics, which are to be blended in cosmetics having high surface activity, and are bis (N-lauroylglutamyl) lysine and ceramide And / or having a lipid bilayer outer shell containing sterol.

  Bis (N-lauroylglutamyl) lysine can be obtained by reacting glutamic acid with lauroyl chloride, forming N-lauroylglutamic acid, and condensing this with lysine using a peptide synthesis reagent such as DCC. Moreover, about this component, the thing already marketed as a raw material for cosmetics exists, and this commercial item can be utilized. As a preferable commercially available product, for example, “Perisea (registered trademark) L-30” (bis (N-lauroylglutamyl) lysine) sold by Asahi Kasei Chemicals and the like exist. Such component is preferably contained in the vesicle in an amount of 1 to 20% by mass, and more preferably 2 to 10% by mass. There are cases where vesicles are not formed outside this range.

  As the ceramide, any of ceramide type 1 to ceramide type 7 can be used, but ceramide type 2 to ceramide type 3 are commercially available, and it is preferable to use such commercially available products. As a commercially available product of ceramide type 2, “ceramide TIC-001” (manufactured by Takasago Inc.), and as ceramide type 3, “ceramide III” (manufactured by Cosmo Farm) can be preferably exemplified. Preferred examples of other types of commercially available ceramides include “Ceramide 1” (Ceramide 1), “Ceramide IIIB” (Ceramide 3), “Ceramide VI” (Ceramide 6) manufactured by Cosmo Farm. This component is preferably contained in the vesicle in an amount of 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass. Further, the content of such a component is preferably the same as that of bis (N-lauroylglutamyl) lysine or 1/5 times the mass. There are cases where vesicles are not formed outside this range.

  Any phytosterol can be used as long as it is generally classified into phytosterols (plant sterols), and those containing campesterol, sitosterol, stigmasteranol and the like can be preferably exemplified. Such components can be obtained by extracting germs of grains and the like with an organic solvent and removing the water-soluble part. However, commercially available products can be purchased. Preferred examples of such commercially available products include “Phytosterol S” (manufactured by Seikagaku Corporation). This component is preferably contained in the vesicle in an amount of 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass. Further, the content of such a component is preferably the same as that of bis (N-lauroylglutamyl) lysine or 1/5 times the mass. The mass ratio of phytosterol and ceramide is preferably 1: 2 to 2: 1. There are cases where vesicles are not formed outside this range.

  These components, encapsulated components, for example, the following active ingredients, yarrow extract such as Achillea millefolium, hypericum extract, longon extract, lauren extract, juju extract, clove extract, clove extract, ponkan extract , Extracts of herbal medicines such as mandarin orange extract, preferably, selected from auren extract, yarrow extract, hypericum extract, clove extract and ponkan extract, ascorbic acid, ascorbic acid phosphate ester, ascorbine Ascorbic acid glycosides such as acid glucoside, 4-alkylresorcinol, arbutin, tranexamic acid or derivatives thereof such as methylamide, or whitening agents represented by these salts, ursolic acid, benzyl ursolate, ursolic acid Ursolic acid such as oleyl Tel, preferably sphingos such as benzyl ursolate, sphingophospholipids, glycosphingolipids, sphingosine, preferably glycosphingolipids, or components other than active ingredients such as water, 1,3-butanediol, 1,2 -The vesicle of the present invention can be obtained by treating a component constituting an inner aqueous phase such as a polyhydric alcohol such as pentanediol and glycerin, a component for adjusting partition wall properties such as a higher alcohol and a nonionic surfactant, etc. according to a conventional method. Can be adjusted. As a specific treatment method, preferably, after coarse emulsification, the particle size is adjusted and adjusted using an extruder, a microfluidizer, or the like. The preferable content of the vesicles thus obtained in the cleansing or cleaning material is preferably 0.005 to 10% by mass, more preferably 0.05 to 5% by mass, based on the total amount of the cosmetic.

(2) Cosmetics of this invention The cosmetics of this invention contain the said vesicle, It is characterized by the above-mentioned. By adopting such a form, it is possible to effectively orient the active ingredient encapsulated in the vesicle into the skin and enhance its effectiveness. Further, by using the vesicles of the present invention, unlike transport globules such as liposomes using phospholipids, the probability of the transport spherules collapsing is extremely low due to the formulation components of cosmetics. It can be applied to cleansing materials containing high oil agents and cleaning materials with extremely high surface activity. In this rare point, cleansing materials and aqueous cleaning materials are preferred embodiments.

  In the cosmetic of the present invention, in addition to the above-mentioned components, components usually used in cosmetics can be optionally contained. Examples of such ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil, Hardened oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba oil, waxes; liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl alcohol Cole, higher alcohols such as behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol, etc .; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpolysiloxane Sun, chain polysiloxane such as diphenylpolysiloxane; cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfates; Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazoli Amphoteric surfactants such as nium hydroxide-1-carboxyethyloxy disodium salt), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), acylmethyl taurine; sorbitan fatty acid esters (sorbitan mono) Stearates, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters ( POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid ester (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl ether) ), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Sho Nonionic surfactants such as sugar fatty acid esters and alkyl glucosides; Acyl (poly) amino acids and / or salts thereof such as bis (N-lauroylglutamic acid) lysine; polyethylene glycol, glycerin, 1,3-butylene Recall, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octane Polyhydric alcohols such as diol; moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate; surface-treated mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (Silica), powders such as aluminum oxide and barium sulfate; inorganic pigments such as bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide, which may be treated on the surface Kind; Mica titanium, fish whose surface may be treated Pearl agents such as phosphorus foil and bismuth oxychloride; red 202, red 228, red 226, yellow 4, blue 404, yellow 5, red 505, red 230, which may be raked Organic dyes such as red 223, orange 201, red 213, yellow 204, yellow 203, blue 1, green 201, purple 201, red 204; polyethylene powder, polymethyl methacrylate, Organic powders such as nylon powder and organopolysiloxane elastomer; paraaminobenzoic acid UV absorbers; anthranilic acid UV absorbers; salicylic acid UV absorbers; cinnamic acid UV absorbers; benzophenone UV absorbers; Sugar-based ultraviolet absorbers; 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t- UV absorbers such as butyldibenzoylmethane; lower alcohols such as ethanol and isopropanol; vitamin A or its derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or its derivatives, vitamin B12, Vitamin B such as vitamin B15 or a derivative thereof; vitamin E such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone Preferred examples include antibacterial agents such as phenoxyethanol. The cosmetic of the present invention can be produced by treating these components and the above essential components according to a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples.

  In accordance with the formulation shown below, a cleansing cosmetic, which is a skin external preparation for cleaning of the present invention, was prepared. That is, the components of (a) and (b) were heated to 80 ° C., and (b) was gradually added to prepare a crude vesicle, which was treated with an extruder to obtain a vesicle dispersion 1. The vesicle was confirmed by the presence of a lipid bilayer structure by a polarizing microscope. Separately, heat C and D to 80 ° C, adjust the temperature of C, D and H to 80 ° C, add emulsified ingredients to C under stirring, neutralize by adding H and stir. Cooling was performed. When the temperature reached 50 ° C., vesicle dispersion 1 was added, and the mixture was stirred and cooled to 30 ° C. to obtain cleansing cosmetic 1. Liposome dispersion 1 was prepared by substituting hydrogenated lecithin for bis (N-lauroylglutamyl) lysine in the vesicle dispersion, and Comparative Example 1 was prepared in the same manner.

<Test Example 1>
The vesicle dispersion 1 was diluted 100 times with water, used as a standard solution, and the cleansing cosmetic 1 and comparative example 1 were stored at 40 ° C. for 1 month, and the vesicles were counted under the microscope and the standard solution as a control using riboflavin as a marker. The vesicle maintenance rate (%) expressed by the number of specimen vesicles observed / the number of standard vesicles observed × 100 was determined. The results are shown in Table 2. Thus, it can be seen that in the formulation system with many solvent components such as cleansing, the liposome has a double membrane structure collapsed and the number decreases, whereas the number of vesicles of the present invention is maintained stably. .

In accordance with the formulation shown below, a cleansing cosmetic, which is a skin external preparation for cleaning of the present invention, was prepared. That is, the components (a) and (b) were heated to 80 ° C., and (b) was gradually added to prepare a crude vesicle, which was treated with an extruder to obtain a vesicle dispersion 2. The vesicle was confirmed by the presence of a lipid bilayer structure by a polarizing microscope. Separately, heat C and D to 80 ° C, adjust the temperature of C, D and H to 80 ° C, add emulsified ingredients to C under stirring, neutralize by adding H and stir. Cooling was performed. When the temperature reached 50 ° C., vesicle dispersion 2 was added, and the mixture was stirred and cooled to 30 ° C. to obtain cleansing cosmetic 2. However, the vesicle maintenance rate obtained by the method of Example 1 was 97%.
Met.

  In accordance with the formulation shown below, a cleansing cosmetic, which is a skin external preparation for cleaning of the present invention, was prepared. That is, the components of a and b were heated to 80 ° C., and b was gradually added to i to prepare a crude vesicle, which was treated with an extruder to obtain a vesicle dispersion 3. The vesicle was confirmed by the presence of a lipid bilayer structure by a polarizing microscope. Separately, heat C and D to 80 ° C, adjust the temperature of C, D and H to 80 ° C, add emulsified ingredients to C under stirring, neutralize by adding H and stir. Cooling was performed. When the temperature reached 50 ° C., vesicle dispersion 3 was added, and the mixture was stirred and cooled to 30 ° C. to obtain cleansing cosmetic 3. However, the vesicle maintenance rate determined by the method of Example 1 was 98%.

  In accordance with the formulation shown below, an aqueous cleansing cosmetic that is a cosmetic of the present invention was prepared. That is, the components of (a) and (b) were heated to 80 ° C., and (b) was gradually added to prepare a crude vesicle, which was treated with an extruder to obtain a vesicle dispersion 1. The vesicle was confirmed by the presence of a lipid bilayer structure by a polarizing microscope. Separately, C and D were each heated to 80 ° C., and C was charged into a vacuum emulsification kettle, adjusted to 80 ° C., neutralized by adding the components of D under stirring, and cooled with stirring under vacuum. When the temperature reached 50 ° C., vesicle dispersion 1 was added, and the mixture was stirred and cooled to 30 ° C. to obtain an aqueous cleaning cosmetic 5. Liposome dispersion 1 was prepared by substituting hydrogenated lecithin for bis (N-lauroylglutamyl) lysine in the vesicle dispersion, and Comparative Example 2 was prepared in the same manner. This was evaluated in the same manner as in Test Example 1. The results are shown in Table 6. This shows that the vesicle of the present invention is excellent in stability.

  The present invention can be applied to cosmetics such as cleansing cosmetics.

Claims (6)

It is a spherule to be blended in cosmetics with high surface activity, and is a vesicle having an outer shell of a lipid bilayer structure containing bis (N-lauroylglutamyl) lysine and ceramide and / or sterol. Special cosmetic spheres. The cosmetic spherule according to claim 1, wherein the sterol is cholesterol and / or phytosterol. It contains an active ingredient selected from the group consisting of ε, γ-glutamyl lysine, oren extract, yarrow extract, hypericum extract, clove extract, ursolic acid, poncan extract and glycosphingolipid The cosmetic spherule according to claim 1 or 2. The cosmetic sphere according to any one of claims 1 to 3, wherein the cosmetic having a high surface activity is a cleansing cosmetic or an aqueous detergent. A cosmetic comprising the cosmetic microsphere according to any one of claims 1 to 4. The cosmetic according to claim 5, wherein the cosmetic is a cleansing cosmetic or an aqueous cleaning material.