JP2007282737A - Liquid level adjusting method of drip chamber for priming liquid - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liquid level adjusting method of a drip chamber for physiological saline capable of automating liquid level adjusting work in the drip chamber for the physiological saline formed in a physiological saline line. <P>SOLUTION: This liquid level adjusting method of the drip chamber for the physiological saline is provided with a first process for filling an upstream side and a downstream side of the drip chamber 10 of the physiological saline in a physiological saline line L4 with the physiological saline and incorporating air in the drip chamber 10 for the physiological saline, a second process for releasing the air in the drip chamber 10 for the physiological saline to the upstream side of the drip chamber 10 for the physiological saline and forming an air layer of a prescribed volume (a prescribed height dimension), and a third process for storing the air in the air layer in the upstream side of the drip chamber 10 for the physiological saline into the interior of the drip chamber 10 for the physiological saline. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a physiological saline drip formed in the middle of a physiological saline line capable of supplying a physiological saline to a blood circuit by connecting a physiological saline containing means containing a predetermined volume of physiological saline at the tip. The present invention relates to a liquid level adjustment method for a chamber.

  As shown in FIG. 5, the dialysis device as a blood purification device has an arterial blood circuit 101 in which an arterial puncture needle (not shown) is attached to the tip 101a, and a venous puncture needle (not shown) in the tip 102a. A blood circuit comprising a venous blood circuit 102, a dialyzer 103 interposed between the arterial blood circuit 101 and the venous blood circuit 102 to purify blood flowing through the blood circuit, and the arterial blood circuit 101. Blood pump 104, arterial drip chambers 105 and 107 and venous drip chamber 106 disposed in the venous blood circuit 101 and venous blood circuit 102, respectively, and a dialysis device capable of supplying dialysate to the dialyzer 103 The main body 108 is mainly constituted.

  Further, from the upstream side of the blood pump 104 in the arterial blood circuit 101, a physiological saline line L101 in which a physiological saline drip chamber 110 is formed is extended in the middle, and a predetermined amount is provided at the tip thereof. A bag 109 containing a physiological saline solution (priming solution) is connected. However, at the time of washing and priming of the blood circuit, the tip 101a of the arterial blood circuit 101 and the tip 102a of the venous blood circuit 102 before the arterial puncture needle and venous puncture needle are attached are connected by, for example, a shunt connector cap or the like. Thus, a circulation circuit is formed, and the physiological saline solution line L101 is connected in the middle of the arterial blood circuit 101.

  In this state, when the blood pump 104 is driven while the electromagnetic valve V1 of the physiological saline line L101 is opened, the physiological saline as the priming fluid in the bag 109 flows through the circulation circuit. When physiological saline overflows from the overflow line L103 of the drip chamber 106, the driving of the blood pump 104 is stopped.

  As a result, the blood circuit before dialysis treatment can be filled with physiological saline as a priming solution, and the blood circuit cleaning and priming operations are completed. Thereafter, in order to perform dialysis treatment, an arterial puncture needle and a venous puncture needle are attached to the distal end 101a of the arterial blood circuit 101 and the distal end 102a of the venous blood circuit 102, respectively, and the patient is punctured with blood. When the pump 104 is driven, blood circulates extracorporeally in the blood circuit, and purification treatment is performed by the dialyzer 103 in the process.

  Incidentally, the physiological saline drip chamber 110 formed in the middle of the physiological saline line L101 has the same configuration as the arterial drip chambers 105 and 107 and the venous drip chamber 106, and is formed inside. While allowing air bubbles in the physiological saline to escape to the air layer side, the flow of the physiological saline can be visually confirmed. In order to adjust the liquid level in the physiological saline drip chamber 110, the following method has been conventionally employed.

  That is, after the physiological saline drip chamber 110 is crushed by hand and the internal air is discharged to the bag 109 side by a desired amount, the physiological saline drip chamber 110 is restored by its restoring force to return to the original shape. A method of introducing and filling a physiological saline solution into the bag 109 or a method of injecting a physiological saline solution with the physiological saline drip chamber 110 inverted and returning to the state in use when an appropriate amount is filled is adopted. It was. Note that the prior art for adjusting the liquid level in the physiological saline drip chamber 110 does not relate to the literature known invention, so there is no prior art document to be described.

  However, in the conventional method for adjusting the liquid level of the physiological saline drip chamber, since manual work by a medical worker or the like is necessary, it is difficult to automatically clean and prime the blood circuit. There was a problem. In other words, in order to perform blood circuit cleaning and priming in an automatic process in order to reduce the burden on medical personnel etc., it is necessary to automatically perform the liquid level adjustment work of the physiological saline drip chamber, In the past, it was exclusively manual work, which hindered automation of cleaning and priming.

  The present invention has been made in view of such circumstances, and is a physiological saline drip chamber that can automate liquid level adjustment work in a physiological saline drip chamber formed in a physiological saline line. It is in providing the liquid level adjustment method.

  The invention according to claim 1 comprises an arterial blood circuit in which an arterial puncture needle is attached to the tip and a venous blood circuit in which a venous puncture needle is attached to the tip, and from the arterial puncture needle to the venous puncture needle A blood circuit capable of extracorporeally circulating a patient's blood, blood purification means for purifying blood flowing between the arterial blood circuit and the venous blood circuit of the blood circuit, and the blood circuit; A physiological saline line that is extended and connected to a physiological saline containing means that contains a predetermined volume of physiological saline at the tip and can supply the physiological saline to the blood circuit, and a middle of the physiological saline line In the method for adjusting the level of the physiological saline drip chamber in the blood purification apparatus comprising the physiological saline drip chamber, the physiological saline storage means is directed toward the blood circuit. The physiological saline in the physiological saline container is forced to flow in the forward direction of the physiological saline line, and the upstream side and the downstream side of the physiological saline drip chamber in the physiological saline line A first step of filling the physiological saline drip chamber with air and a physiological solution in the physiological saline line in a direction opposite to the forward direction after the first step; Forced to flow, the air in the physiological saline drip chamber is allowed to escape to the upstream side of the physiological saline drip chamber to form an air layer, and forced when the air in the air layer reaches a predetermined volume. A second step of stopping the flow, and after the second step, the physiological saline is forcibly flowed in the forward direction of the physiological saline line, and is emptied upstream of the physiological saline drip chamber. And having a third step of accommodating the air layer to the saline solution for a drip chamber.

  According to a second aspect of the present invention, in the method for adjusting the liquid level of the physiological saline drip chamber according to the first aspect, the blood purification device is an arterial drip chamber connected to the arterial blood circuit or the venous blood circuit. Or a venous drip chamber, an arterial drip chamber or an open line extending from the air layer side of the venous drip chamber, and a squeezing pump disposed in the middle of the open line. And an air pump capable of adjusting the liquid level of the arterial drip chamber or the venous drip chamber through the open line and adjusting the liquid level of the arterial drip chamber or the venous drip chamber. Or, by reversing, the physiological saline line is forced to flow forward or backward And characterized in that.

  According to a third aspect of the present invention, in the drip chamber adjustment method for the physiological saline drip chamber according to the first or second aspect, air upstream of the physiological saline drip chamber in the physiological saline line is provided. An air detection sensor that can be detected is disposed, and the air detection sensor detects a predetermined volume of the air layer in the second step.

  According to a fourth aspect of the present invention, in the drip chamber adjustment method for the physiological saline drip chamber according to the first or second aspect, the second step is a step of supplying the physiological saline solution in the physiological saline line for a predetermined time. By forcedly flowing in the reverse direction, the air layer in the physiological saline drip chamber has a predetermined volume.

  According to the first aspect of the present invention, the air layer having a predetermined volume in the second step is accommodated in the physiological saline drip chamber in the third step, and the liquid level is set at a desired position. By sequentially performing the first to third steps, it is possible to automate the liquid level adjustment operation in the physiological saline drip chamber formed in the physiological saline line.

  According to the invention of claim 2, since the physiological saline in the physiological saline line can be forced to flow in the forward direction or the reverse direction by rotating the air pump forward or backward, the first step is performed by driving the air pump. The third process can be sequentially performed, and the liquid level of the arterial drip chamber or the venous drip chamber can be adjusted by the air pump at the time of treatment. Further, the present invention can be easily applied to an existing blood purification apparatus in which an air pump is connected to an arterial drip chamber or a venous drip chamber.

  According to the invention of claim 3, since the predetermined volume of the air layer in the second step is detected by the air detection sensor, the desired liquid level position can be obtained more reliably, and the air detection sensor It can be used as a sensor for running out of physiological saline.

  According to the invention of claim 4, in the second step, the physiological saline line drip chamber is forced to flow in the reverse direction for a predetermined time, so that the air layer in the physiological saline drip chamber has a predetermined volume. Therefore, it can be easily applied to a physiological saline line that does not have an air detection sensor or the like.

Hereinafter, embodiments of the present invention will be specifically described with reference to the drawings.
The blood purification apparatus according to this embodiment includes a dialysis apparatus for performing dialysis treatment. As shown in FIG. 1, a blood circuit including an arterial blood circuit 1 and a venous blood circuit 2, and an arterial blood circuit 1. And a dialyzer 3 (blood purification means) interposed between the venous blood circuit 2 and purifying blood flowing in the blood circuit, a blood pump 4, an arterial drip chamber 5, 7 and a venous drip chamber 6, It mainly comprises a physiological saline line L4 in which a physiological saline drip chamber 10 is formed, and a dialyzer body 8 that can supply dialysate 3 to the dialyzer 3.

  The arterial blood circuit 1 has a tip 1a to which an arterial puncture needle can be connected, and an iron-type blood pump 4 and arterial drip chambers 5 and 7 for defoaming in the middle (blood pumps) 4 and the dialyzer 3, an arterial drip chamber 5, and an arterial drip chamber 7) between the blood pump 4 and the connection between the physiological saline line L 4 and the arterial blood circuit 1. On the other hand, the distal side 2a of the venous blood circuit 2 can be connected to a venous puncture needle, and a venous drip chamber 6 is connected midway.

  When the blood pump 4 is driven while the patient is punctured with the arterial puncture needle and the venous side puncture needle, the blood of the patient reaches the dialyzer 3 through the arterial blood circuit 1 and then the dialyzer 3. As a result, blood purification is performed, and bubbles are removed in the venous drip chamber 6 and returned to the patient's body through the venous blood circuit 2. That is, the patient's blood is purified by the dialyzer 3 while being circulated extracorporeally in the blood circuit. An overflow line L3 is extended from the air layer (upper) side of the venous drip chamber 6, and an electromagnetic valve V2 capable of closing the flow path of the overflow line L3 is provided in the middle. Yes.

  The dialyzer 3 is formed with a blood introduction port 3a, a blood outlet port 3b, a dialysate inlet port 3c, and a dialysate outlet port 3d in the casing. Among these, the blood inlet port 3a includes the arterial blood circuit 1. However, the venous blood circuit 2 is connected to the blood outlet port 3b. The dialysate introduction port 3c and the dialysate lead-out port 3d are connected to a dialysate introduction line L1 and a dialysate discharge line L2 extending from the dialyzer body 8, respectively.

  A plurality of hollow fibers are accommodated in the dialyzer 3, the inside of the hollow fibers is used as a blood flow path, and the flow of dialysate is between the hollow fiber outer peripheral surface and the inner peripheral surface of the housing. It is considered a road. A hollow fiber membrane is formed in the hollow fiber by forming a large number of minute holes (pores) penetrating the outer circumferential surface and the inner circumferential surface, and impurities in the blood are passed through the membrane in the dialysate. It is comprised so that it can permeate | transmit.

  On the other hand, the dialyzer body 8 is provided with a water removal pump (not shown) for removing water from the blood of the patient flowing in the dialyzer 3, and one end of the dialysate introduction line L1 is connected to the dialyzer. 3 (dialysate introduction port 3c), and the other end is connected to a dialysate supply device (not shown) for preparing a dialysate having a predetermined concentration. One end of the dialysate discharge line L2 is connected to the dialyzer 3 (dialysate outlet port 3d), and the other end is connected to a waste fluid means (not shown), so that the dialysate supplied from the dialysate supply device is After reaching the dialyzer 3 through the dialysate introduction line L1, the dialysate discharge line L2 is sent to the waste liquid means.

  A saline solution line L3 extends from between the tip 1a of the arterial blood circuit 1 and the blood pump 4, and a bag 7 (saline solution) containing a predetermined amount of priming solution (saline solution) at the tip thereof. Storage means) is connected. In the middle of the physiological saline line L3, a physiological saline drip chamber 10 and an electromagnetic valve V1 are arranged. By blocking the flow path by the electromagnetic valve V1, the physiological saline is supplied to the blood circuit side. Supply can be stopped. The physiological saline drip chamber 10 has an accommodation space having a diameter larger than that of the flow path in the physiological saline line L3, and has the same configuration as the arterial drip chambers 5 and 7 and the venous drip chamber 6. It is said that.

  When the blood pump 4 is driven while the electromagnetic valve V1 is opened, the physiological saline in the bag 7 is supplied into the blood circuit via the physiological saline line L4, and in the process, the physiological saline is supplied. Passes through the drip chamber 10 for physiological saline, so that air bubbles in the physiological saline can escape to the air layer formed inside and the flow of the physiological saline can be visually confirmed. .

  In addition, an air detection sensor 12 capable of detecting air flowing through the physiological saline line L4 is disposed on the upstream side (bag 9 side) of the physiological saline drip chamber 10 in the physiological saline line L4. ing. The air detection sensor 12 transmits / receives ultrasonic waves and light via, for example, the physiological saline line L4, and detects whether liquid (physiological saline) is flowing through the part or whether air is flowing. It is configured to be able to.

  Here, in this embodiment, as shown in FIG. 3, the air detection sensor 12 is disposed at a position where the dimension from the bottom surface of the bag 9 (connecting portion with the physiological saline line L4) becomes Ta. ing. The dimension Ta is determined based on the dimension Tb of the desired air layer to be formed in the physiological saline drip chamber 10 (see FIG. 4), and the volume of air in the dimension Ta and the volume of air in Tb are the same. It is set to become.

  On the other hand, from the side (upper part) where the air layer is formed in the arterial drip chambers 5 and 7 and the venous drip chamber 6, an open line L5 in which the tip a is opened to the atmosphere is extended. A squeezing type air pump 11 is disposed on the distal end a side of the open line L5, and air is introduced into or discharged from the arterial drip chambers 5 and 7 and the venous drip chamber 6 by forward and reverse driving. The liquid level of the drip chamber can be adjusted.

  That is, if air is introduced through the open line L5, the liquid level in each drip chamber is lowered, and if air is discharged, the liquid level is raised. Therefore, the air pump 11 can be driven so as to be at an arbitrary liquid level. For example, the liquid level of these drip chambers can be adjusted. However, electromagnetic valves V3 to V5 are disposed at appropriate positions on the open line L5. By selectively opening or closing these electromagnetic valves, any arterial drip chamber 5, 7 or Air can be introduced or discharged by the air pump 11 to the venous drip chamber 6.

  A pressure monitor line extending from the arterial drip chambers 5 and 7 and the venous drip chamber 6 to the pressure sensors P1 to P3 is formed. In the present embodiment, the pressure monitor line is further branched to provide an electromagnetic valve V3. A line extending to ~ a through V5 is an open line L5. That is, in the open line L5, when the liquid level is adjusted, the electromagnetic valves V3 to V5 are opened and the action of the air pump 11 is exerted on the air layer of each drip chamber, and during the subsequent treatment, the electromagnetic valves V3 to V5 are applied. Is closed, and the pressures in the air layers of the arterial drip chambers 5 and 7 and the venous drip chamber 6 are measured by the pressure sensors P1 to P3.

Next, the liquid level adjustment method of the physiological saline drip chamber 10 in the dialysis apparatus will be described.
First, as shown in FIG. 1, the distal end 1a of the arterial blood circuit 1 interposing the dialyzer 3 and the distal end 2a of the venous blood circuit 2 are connected to form a circulation circuit, and then the electromagnetic valve V1 is opened. The physiological saline line L3 is opened as a state, and the air pump 11 is driven to rotate forward (first step). At this time, the electromagnetic valve V4 is opened, the electromagnetic valves V3 and V5 are closed, and the dialysate introduction line L1 and the dialysate discharge line L2 are closed by an electromagnetic valve (not shown).

  Then, as shown in FIG. 2, the physiological saline in the bag 9 is forced to flow in the forward direction of the physiological saline line L4 from the bag 9 toward the blood circuit (in the direction of the arrow in FIG. 2). The upstream side and the downstream side of the physiological saline drip chamber 10 in the line L4 are filled with physiological saline. At this time, since the diameter of the physiological saline drip chamber 10 is larger than the diameter of the physiological saline line L4, the physiological saline passes through the physiological saline drip chamber 10 but does not accumulate (reserve). Even if a small amount is accumulated at the bottom), the state in which air is contained is maintained.

  After the first step, the drive of the air pump 11 is reversed to force the physiological saline in the physiological saline line L4 to flow in the direction opposite to the forward direction (in the direction of the arrow in FIG. 3) as shown in FIG. 2 steps). Thereby, the air in the physiological saline drip chamber 10 is released to the upstream side of the physiological saline drip chamber 10, and an air layer is formed at that portion. The escaped air reaches the air layer in the bag 9.

  Thus, in the process of air escaping to the bag 9 side on the upstream side of the physiological saline line L4, the boundary surface between the air layer and the physiological saline (the level of the flowing physiological saline) is used for air detection. The air pump 11 is controlled to stop when the sensor 12 detects it. Thereby, the forced flow of the physiological saline in the reverse direction is stopped, and the height dimension of the air layer in the physiological saline line L4 is adjusted to Ta. That is, in the first step, after the air is contained in the physiological saline drip chamber 10, air is released in the second step until the volume of the air becomes desired.

  Thereafter, as shown in FIG. 4, if the physiological saline is forced to flow in the forward direction of the physiological saline line L <b> 4 by rotating the air pump 11 again forward, the upstream side of the physiological saline drip chamber 10. The air in the air layer (air in the dimension Ta) can be accommodated in the physiological saline drip chamber 10 (third step). Accordingly, since the air layer A having a height dimension of Tb is formed in the physiological saline drip chamber 10, the liquid level in the physiological saline drip chamber 10 becomes a desired position.

  The liquid level adjustment operation of the physiological saline drip chamber 10 is thus completed, and if the blood pump 4 is subsequently driven while maintaining the state in which the blood circuit constitutes the circulation circuit, the inside of the blood circuit is filled with physiological saline. Priming can be performed by filling with a liquid. Thereafter, the distal end 1a of the arterial blood circuit 1 and the distal end 2a of the venous blood circuit 2 of the blood circuit filled with physiological saline are disconnected, and an arterial puncture needle and a venous puncture needle are respectively attached to the patient. In addition, the blood pump 4 is driven and blood is circulated extracorporeally in the blood circuit to purify and remove water with the dialyzer 3 to perform dialysis treatment.

  According to the liquid level adjustment method of the physiological saline drip chamber 10, the air layer having a predetermined volume (height dimension Ta) in the second step is accommodated in the physiological saline drip chamber 10 in the third step, Since the liquid level is set to a desired position, the liquid level adjustment work in the physiological saline drip chamber 10 formed in the physiological saline line L4 is performed sequentially through the first to third steps. Can be automated.

  Further, since the physiological saline in the physiological saline line L4 can be forced to flow in the forward direction or the reverse direction by rotating the air pump 11 forward or backward, the first to third steps are driven by driving the air pump 11. The air pump 11 can adjust the liquid level of the arterial drip chambers 5 and 7 or the venous drip chamber 6 at the time of treatment. Further, the present invention can be easily applied to an existing dialysis apparatus in which the air pump 11 is connected to the arterial drip chambers 5 and 7 or the venous drip chamber 6.

  Further, since the air detection sensor 12 detects the predetermined volume (height dimension Ta) of the air layer in the second step, the air layer A can be more reliably set to a desired liquid level position, and the air The sensor 12 for detection can be used as a sensor for running out of physiological saline. Instead of detecting the air layer by the air detection sensor 12, for example, the driving time of the air pump 11 in the second step may be set to a predetermined value. In this case, in the second step, if the time until the height dimension of the air layer reaches the desired height is measured in advance and the air pump 11 is driven (reversed) for that time, the first step is the same as in the above embodiment. The liquid level in the physiological saline drip chamber 10 can be automatically adjusted in three steps. As described above, in the second step, if the physiological saline solution L4 is forced to flow in the reverse direction for a predetermined time to make the air layer in the physiological saline drip chamber 10 have a predetermined volume, The present invention can be easily applied to a physiological saline line L4 that does not have an air detection sensor or the like.

  Although the present embodiment has been described above, the present invention is not limited to this. For example, while the electromagnetic valves V4 and V3 in the open line L5 are closed, the electromagnetic valve V5 is opened and the air pump 11 is driven ( You may comprise so that the said 1st process thru | or 3rd process may be performed by making it rotate forward or reverse). In this case, although the connection position of the arterial drip chamber 7 needs to be set so that the physiological saline that is forced to flow forward in the first step has a sufficient amount, as in the above embodiment. The liquid level in the physiological saline drip chamber 10 can be automatically adjusted.

  Further, if the blood pump 4 can be rotated forward and backward, the blood pump 4 can perform the first to third steps. Specifically, the blood pump 4 is rotated forward, the physiological saline in the bag 9 is forced to flow forward in the physiological saline line L4 (first step), the blood pump 4 is reversed, and the physiological The physiological saline solution in the saline solution line L4 is forced to flow in the reverse direction, and the forced flow is stopped when the air layer reaches an arbitrary height (dimension Ta) (second step). Then, when the blood pump 4 is rotated forward again and the air layer within the dimension Ta is accommodated in the physiological saline drip chamber 10, the liquid in the physiological saline drip chamber 10 is the same as in the above embodiment. The face can be adjusted automatically.

  The arterial blood circuit can be applied to one in which only one drip chamber is formed, or the arterial blood circuit in which no drip chamber is formed. In that case, the action of the air pump is exerted on the physiological saline line side through the vein drip chamber. In this embodiment, the present invention is applied to a dialysis apparatus used at the time of dialysis treatment, but is used in other apparatuses that can purify the patient's blood while circulating it outside the body (for example, blood filtration dialysis, blood filtration, AFBF). The present invention may be applied to blood purification devices, plasma adsorption devices, and the like.

  A first step of filling the physiological saline drip chamber upstream and downstream of the physiological saline drip chamber with physiological saline, and causing air to be contained in the physiological saline drip chamber; A second step of releasing air in the drip chamber upstream of the physiological saline drip chamber to form an air layer of a predetermined volume; and air in the air layer upstream of the physiological saline drip chamber The liquid level adjusting method of the physiological saline drip chamber having the third step to be accommodated in the physiological saline drip chamber can be applied to other forms and uses.

Overall schematic diagram showing a dialysis device (blood purification device) applied to an embodiment of the present invention It is a fragmentary figure which shows the range where the effect | action of the air pump in the same dialysis apparatus is exerted, Comprising: Explanatory drawing for demonstrating a 1st process It is a fragmentary figure which shows the range where the effect | action of the air pump in the same dialysis apparatus is extended, Comprising: Explanatory drawing for demonstrating a 2nd process It is a fragmentary figure which shows the range where the effect | action of the air pump in the same dialysis apparatus is extended, Comprising: Explanatory drawing for demonstrating a 3rd process Schematic diagram showing a conventional dialysis machine

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Arterial blood circuit 2 Vein side blood circuit 1a, 2a Tip 3 Dialyzer (blood purification means)
4 Blood Pump 5, 7 Arterial Drip Chamber 6 Venous Drip Chamber 8 Dialyzer Main Body 9 Bag (Saline Solution Storage Means)
10 Saline drip chamber 11 Air pump 12 Air detection sensor L1 Dialysate introduction line L2 Dialysate discharge line L3 Overflow line L4 Saline solution line L5 Open line

Claims (4)

It comprises an arterial blood circuit with an arterial puncture needle attached to the tip and a venous blood circuit with a venous puncture needle attached to the tip, and can circulate the patient's blood extracorporeally from the arterial puncture needle to the venous puncture needle Blood circuit,
Blood purification means for purifying blood flowing between the arterial blood circuit and the venous blood circuit of the blood circuit and flowing through the blood circuit;
A physiological saline line that extends from the blood circuit and is connected to a physiological saline storage means that stores a predetermined volume of physiological saline at the tip, and can supply the physiological saline to the blood circuit;
A physiological saline drip chamber formed in the middle of the physiological saline line;
In the method for adjusting the liquid level of the drip chamber for physiological saline in the blood purification apparatus comprising:
Forcing the physiological saline in the physiological saline containing means to flow in the forward direction of the physiological saline line from the physiological saline containing means to the blood circuit, and for the physiological saline in the physiological saline line A first step of filling the upstream and downstream sides of the drip chamber with physiological saline and causing air to be contained in the physiological saline drip chamber;
After the first step, physiological saline in the physiological saline line is forced to flow in a direction opposite to the forward direction, and air in the physiological saline drip chamber is upstream of the physiological saline drip chamber. A second step of escaping to the side to form an air layer and stopping forced flow when the air in the air layer reaches a predetermined volume;
After the second step, the physiological saline is forced to flow in the forward direction of the physiological saline line, and the air in the air layer upstream from the physiological saline drip chamber is allowed to enter the physiological saline drip chamber. A third step of accommodating;
A method for adjusting the liquid level of a drip chamber for physiological saline. The blood purification device comprises:
An arterial drip chamber or venous drip chamber connected to the arterial blood circuit or venous blood circuit;
An open line extending from the air layer side of the arterial drip chamber or venous drip chamber;
It comprises a squeezing type pump disposed in the middle of the open line, and introduces or discharges air through the open line to the arterial drip chamber or venous drip chamber, and these arterial drip chamber or venous drip An air pump capable of adjusting the liquid level in the chamber;
2. The physiological saline solution according to claim 1, wherein the physiological saline line is forcibly flowed in a forward direction or a reverse direction by rotating the air pump forward or backward. Liquid level adjustment method for drip chamber.   An air detection sensor capable of detecting air upstream of the physiological saline drip chamber in the physiological saline line is disposed, and a predetermined volume of the air layer in the second step is detected by the air detection sensor. 3. The liquid level adjustment method of the drip chamber for physiological saline according to claim 1, wherein the drip chamber for physiological saline is detected.   In the second step, the physiological saline drip chamber has a predetermined volume by forcibly flowing the physiological saline in the physiological saline line in a reverse direction for a predetermined time. The liquid level adjustment method of the drip chamber for physiological saline according to claim 1 or 2.

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