JP2007268487A - Method for controlling fluid in microchemical apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method capable of reducing an adverse influence caused by insufficient precision in making an apparatus and uniformly mixing or reacting a plurality of fluids with each other in a stable state of multi-layered flow. <P>SOLUTION: In the method for controlling a fluid in a microchemical apparatus having coaxially multi-layered flow paths for mixing or reacting a plurality of fluids with each other by allowing each of the fluids to individually flow through corresponding coaxially multilayered first and third fluid supply paths 22, 26 and subsequently allowing the fluids to flow through a single mixing and reaction microflow path 36, an irregularly flowing fluid L1 is regulated to coaxially flow relative to the mixing and reaction microflow path 36 by allowing an inactive fluid LN unreactive to and having a velocity and/or viscosity higher than the plurality of fluids to flow outside the irregularly flowing fluid L1 which is one of the plurality of fluids and is not coaxially flowing relative to the mixing and reaction microflow path 36. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a fluid manipulation method for a micro scientific device, and more particularly, to a fluid manipulation method for a micro scientific device in which a laminar flow is stably formed to react or mix a plurality of fluids.

  Since the surface area per unit volume is large in the micro space, many reaction interfaces of the reaction fluid can be formed, and temperature control can be easily performed.As a technology that can increase the efficiency and speed of reaction and mixing between fluids. Attention has been paid.

  In a micro scientific apparatus using such a micro space, in order to perform reaction and mixing uniformly and efficiently, it is important to combine reaction fluids in a stable multilayer flow state. Then, by precisely controlling the interface area and the layer thickness of the uniform multilayer flow, a uniform reaction can be performed while controlling the molecular diffusion at the interface.

  For example, Patent Document 1 proposes a method for producing a silver halide emulsion using a reactor provided with a multi-coaxial nozzle formed by an inner shaft tube and an outer shaft tube introduced from a side surface of the inner shaft tube. ing.

Patent Document 2 proposes a flow-type micro reaction channel provided with an introduction channel that joins the main channel from the side wall of the cylindrical main channel. According to these Patent Documents 1 and 2, it is said that the reaction fluids can be reacted or mixed by confluence with a concentric cylindrical laminar flow.
Japanese Patent Laid-Open No. 4-139440 JP 2002-292274 A

  However, the micro scientific apparatus for forming the concentric multi-layered cylindrical laminar flow as in the above-described conventional example often has low manufacturing accuracy such as processing / assembly accuracy, and the cross sections of a plurality of fluids flowing in the flow path are uniform. It was difficult to achieve a concentric multi-layered annular shape, which made it difficult to uniformly react or mix.

  For example, when the thickness variation, core misalignment, inclination, etc. of the inner pipe constituting the multiple pipe structure occur, the cross section of the fluid flowing in the pipe after joining does not have a concentric shaft shape, so-called `` non-rectification '' It becomes a distorted shape called. For this reason, in order to form a desired concentric-axis multi-layer cylindrical laminar flow, it is necessary to improve the level of manufacturing technology, and as a method therefor, ultra-precision machining technology is required. However, as a practical problem, there is a problem that the cost is high in consideration of the yield, and a countermeasure method has been desired.

  The present invention has been made in view of such circumstances, and reduces the adverse effects caused by the accuracy of manufacturing the device, and is a micro scientific device capable of uniformly reacting or mixing a plurality of fluids in a stable laminar flow state. An object is to provide a fluid manipulation method.

  According to the first aspect of the present invention, in order to achieve the above object, a plurality of fluids are circulated in a concentric-shaft multilayer supply channel, and then are circulated through one fine mixing / reaction channel. In the fluid operation method of the concentric axial multi-layer flow type micro scientific apparatus to mix or react, among the plurality of fluids, outside the non-rectifying body that does not flow concentrically with respect to the mixing / reaction channel, By flowing an inert fluid that does not react with the plurality of fluids and has a higher flow velocity and / or viscosity than the plurality of fluids, the flow of the non-rectifying body is concentric with the mixing / reaction channel. Provided is a fluid manipulation method of a micro scientific device, wherein the fluid is corrected so as to flow in a shape.

  According to claim 1, a plurality of fluids are circulated in a concentric-shaft multilayer supply channel, respectively, and then mixed or reacted by being circulated through one fine mixing / reaction channel. In the fluid manipulation method of the axial multilayer flow type micro scientific apparatus, a plurality of fluids that do not react with a plurality of fluids outside the non-rectifying body that does not flow concentrically with the mixing / reaction flow path The flow of the non-rectifying body is corrected by flowing an inert fluid having a higher flow velocity and / or higher viscosity than the above fluid. Thereby, the bad influence resulting from the manufacture precision of an apparatus can be reduced, and a plurality of fluids can be reacted or mixed uniformly in a stable laminar flow state.

  Here, the non-rectifying body that does not flow concentrically with a single fine mixing / reaction channel is the same as described above, for example, an inner tube constituting a concentric multi-layer channel This refers to fluid that flows unevenly or distorted due to poor manufacturing accuracy such as wall thickness variation, core misalignment, and inclination. The inert fluid refers to a fluid that is inert to the reaction between a plurality of fluids including a non-rectifier, such as water, silicone oil, fluorine-based inert liquid (for example, Fluorinert manufactured by Sumitomo 3M), and the like. Can be mentioned. The fine mixing / reaction channel preferably has an equivalent circle diameter of 1 mm or less.

  A second aspect of the present invention is the method of the first aspect, wherein the inert fluid is flowed to the outside adjacent to the non-rectifying body to correct the flow of the non-rectifying body, and then the plurality of fluids including the non-rectifying body are joined together in a multilayer shape. It is characterized by that.

  According to the second aspect, it is possible to prevent the non-rectifying body in a non-uniform flow state from coming into contact with other fluids directly involved in the reaction. Thereby, the bad influence resulting from the manufacture precision of an apparatus can be reduced, and a plurality of fluids can be reacted or mixed uniformly in a stable laminar flow state.

  A third aspect is characterized in that, in the first or second aspect, the viscosity of the inert fluid is 1 to 10 times the viscosity of the non-rectifying body.

  According to claim 3, since the viscosity of the inert fluid is as high as 1 to 10 times the viscosity of the non-rectifying body, the inertia force of the inert fluid is superior to the inertia force of the non-rectifying body, and the reaction caused by the manufacturing accuracy. Fluid non-rectification can be corrected. Thereby, the bad influence resulting from the manufacture precision of an apparatus can be reduced, and a plurality of fluids can be reacted or mixed uniformly in a stable laminar flow state. Moreover, it is more preferable that the viscosity of the inert fluid is 1 to 5 times the viscosity of the non-rectifying body.

  A fourth aspect of the present invention is characterized in that, in the first or second aspect, the flow rate of the inert fluid is 1 to 10 times the flow rate of the non-rectifying body.

  According to the fourth aspect, since the flow rate of the inert fluid is 1 to 10 times the flow rate of the non-rectifying body, the non-rectification of the reaction fluid due to the manufacturing accuracy can be corrected. More preferably, the flow rate of the inert fluid is 1 to 5 times the flow rate of the non-rectifying body.

  According to the fifth aspect of the present invention, in order to achieve the above object, a plurality of fluids are circulated in the concentric-shaft multi-layered supply flow path, and then mixed in a single fine mixing / reaction flow path. Alternatively, in the fluid manipulation method of the concentric axial multi-layer flow type micro scientific apparatus to be reacted, by applying an external force to the non-rectifying body that does not flow concentrically with respect to the mixing / reaction channel among the plurality of fluids. A fluid manipulation method for a micro scientific device is provided, wherein the flow of the non-rectifying body is corrected so as to flow in a concentric axial shape with respect to the mixing / reaction channel.

  According to claim 5, the concentric cores are mixed or reacted by circulating a plurality of fluids in the concentric multi-layered supply flow channel and then flowing them through one fine mixing / reaction flow channel. In the fluid operation method of the axial multi-layer flow type micro scientific device, the flow of the non-rectifying body is corrected by applying an external force to the non-rectifying body that does not flow concentrically with respect to the mixing / reaction channel among a plurality of fluids. To do. Thereby, the bad influence resulting from the manufacture precision of an apparatus can be reduced, and a plurality of fluids can be reacted or mixed uniformly in a stable laminar flow state. Here, the external force refers to gravity or magnetic force applied in a direction to correct non-uniformly flowing fluid.

  A sixth aspect of the present invention according to the fifth aspect is characterized in that the external force is gravity.

  According to the sixth aspect, for example, by tilting the apparatus using gravity, it is possible to reduce non-uniformity and distortion of the flow of the reaction fluid due to manufacturing accuracy.

  A seventh aspect is characterized in that, in the fifth aspect, the non-rectifying body includes a magnetic substance, and a magnetic field is applied to the non-rectifying body as the external force.

  According to the seventh aspect, a magnetic substance is contained in a non-rectifying body that flows nonuniformly due to manufacturing accuracy, and a magnetic field is applied as an external force. Thereby, the magnetic substance in a non-rectifier body receives the effect | action of magnetic force, and can reduce the nonuniformity of a flow of a non-rectifier body, distortion, etc.

  According to the present invention, it is possible to reduce adverse effects caused by the manufacturing accuracy of the apparatus and to uniformly react or mix a plurality of fluids in a stable multilayer flow state.

  Preferred embodiments of a fluid manipulation method for a micro scientific apparatus according to the present invention will be described below with reference to the accompanying drawings.

[First embodiment]
FIG. 1 is a cross-sectional view illustrating an example of the configuration of the micro scientific apparatus 10 according to the present embodiment. 2A is an enlarged cross-sectional view of the vicinity of the joining portion of the micro scientific apparatus 10 of FIG. 1, and FIG. 2B is a cross-sectional view taken along the line AA ′ of FIG. These drawings show an example in which the manufacturing accuracy of the first partition member is low. Hereinafter, although the example of the liquid-liquid reaction which produces | generates reaction product LM between liquid L1 and L2 is demonstrated, it is not limited to this. In this embodiment, an example of a concentric multi-layer cylindrical laminar flow type micro-scientific apparatus having a problem in manufacturing accuracy will be described. However, the present invention is not limited thereto.

  As shown in FIG. 1, the microscience device 10 is formed in a substantially cylindrical shape as a whole, and mainly includes a cylindrical circular tube portion 12 that constitutes an outer shell portion of the device. Here, the straight line S in the figure indicates the axial center of the apparatus, and the following description will be made with the direction along the axial center S as the axial direction of the apparatus.

  The equivalent circle diameter D of the circular pipe portion 12 is preferably 1 mm or less, and more preferably 500 μm or less. In the present embodiment, an example in which the cross-sectional shape of the concentric axial multilayer flow path and one mixing / reaction flow path is circular is shown, but the present invention is not limited to this, and may be rectangular, V-shaped, or the like.

  A discharge port 14 for the reaction product liquid LM after the liquids L <b> 1 and L <b> 2 have reacted is opened at the distal end surface of the circular pipe part 12.

  In the circular pipe part 12, a cylindrical first partition member 16 and a second partition member 18 that divide the space in the circular pipe part 12 along the axial direction are provided in multiple cylinders, and each partition member 16, The base end surface of 18 is fixed to the base end portion of the circular pipe portion 12. These first and second partition members 16 and 18 are originally arranged coaxially with the circular pipe part 12 and are partitioned so as to divide the space of the cross-sectional circle in the circular pipe part 12 into three coaxially. However, in the present embodiment, an example will be described in which the liquid L1 forms a non-rectifying body when the manufacturing accuracy of the first partition member 16 is low and the first partition member 16 is not arranged coaxially.

  Although not shown, a plurality of spacers may be interposed between the inner peripheral surface of the circular pipe portion 12 and the outer peripheral surface of the first partition member 16 or the second partition member 18. As a result, the two partition members 16 and 18 are connected and fixed to the circular pipe portion 12 with sufficient strength, and are displaced or deformed from a predetermined position under the influence of the liquid pressure of the liquids L1, L2, and LN. Is prevented.

  As shown in FIG. 2A, the first fluid supply path 22 and the second fluid are formed in order from the axial center side through the sectional circle and the sectional annular space partitioned by the first and second partition members 16 and 18. A supply path 24 and a third fluid supply path 26 are provided. In addition, fluid supply pipes 28, 30, and 32 that supply liquid to the fluid supply paths 22, 24, and 26 are connected to the base end surface of the circular pipe portion 12.

  As a result, three fluid supply sources (see FIG. 3) installed on the upstream side of the micro scientific apparatus 10 in the first to third fluid supply paths 22, 24, and 26 through the fluid supply pipes 28, 30, and 32. The liquid L1, the inert liquid LN, and the liquid L2 that are in a pressurized state are supplied from (not shown).

  Here, the inert liquid LN is a liquid that corrects the non-rectification of the liquid L1 flowing through the first partition member 16 with low manufacturing accuracy, and is inert to the liquids L1 and L2.

  Such an inert liquid LN preferably has a high viscosity, more preferably 1 to 10 times the viscosity of the non-rectifying body, and further preferably 1 to 5 times the viscosity of the non-rectifying body.

  The flow rate of the inert liquid LN is preferably large, more preferably 1 to 10 times the flow rate of the non-rectifying body, and further preferably 1 to 5 times the flow rate of the non-rectifying body.

  By setting it as the above ranges, the non-rectification of the liquid L1 supplied from the 1st partition member 16 with low manufacture precision can be corrected effectively.

  Further, in the circular pipe portion 12, the liquid L1 and the inert liquid LN respectively supplied from the fluid supply passages 22 and 24 join to the tip side of the first partition member 16, and the flow of the liquid L1 is inactive. A correction flow path 34 for correcting with the liquid LN is formed. Further, on the tip side of the second partition member 18, a mixed / reaction channel in which the corrected liquid (L1 + LN) and the liquid L2 supplied from the correction channel 34 and the fluid supply channel 26 are combined to react. 36 is formed.

  Here, it is preferable that the correction of the flow of the liquid L1 is almost completed at the outlet in the correction flow path 34. Therefore, it is preferable that the path length PL (see FIG. 1) along the flow direction of the liquid L1 and the inert liquid LN in the correction flow path 34 is set to a length at which the correction of the flow of the liquid L1 is almost completed. However, even if the tip of the second partition member 18 is configured to be shorter than the first partition member 16, the non-rectification of the liquid L1 can be corrected if the liquid LN can flow stably to the outer peripheral layer of the liquid L1. be able to.

  As an operation order of the liquid L1, the inert liquid LN, and the liquid L2, it is preferable to start or end the circulation so that the liquid L2 and the non-rectifying liquid L1 do not directly contact each other. For example, it is preferable to start supplying the liquid L1 after starting the supply of the liquid L1 and the inert liquid LN first. Thereby, it can suppress that the liquid L1 which forms non-rectification contacts the liquid L2 directly.

  As shown in FIG. 2 (A), the first fluid supply path that opens into the correction flow path 34 is provided at the distal ends of the first fluid supply path 22, the second fluid supply path 24, and the third fluid supply path 26, respectively. A port 38 and a second fluid supply port 40 opening into the mixing / reaction channel 36 are formed. These fluid supply ports 38 and 40 are originally opened in a circular cross section along a circular locus centered on the axis S, and are arranged so as to be concentric with each other. Here, the opening widths W1, W2, and W3 define the opening areas of the fluid supply ports 38 and 40, respectively, and according to the opening areas of the fluid supply ports 38 and 40 and the supply amounts of the liquid (L1 + LN) and L2, The initial flow rates of the liquids L1, L2, and LN introduced into the mixing / reaction channel 36 through the fluid supply ports 38 and 40 are determined.

  In the space on the tip side of the mixing / reaction channel 36 in the circular pipe portion 12, the reaction product liquid LM in which the liquids L <b> 1 and L <b> 2 are reacted in the mixing / reaction channel 36 is directed toward the discharge port 14. A drainage flow path is formed. Here, when the reaction product liquid LM is generated by the reaction of the liquids L1 and L2, the reaction of the liquids L1 and L2 needs to be completed at the outlet in the mixing / reaction channel 36. Therefore, the path length QL (see FIG. 1) along the flow direction of the liquids L1 and L2 in the mixing / reaction channel 36 needs to be set to a length at which the reaction of the liquids L1 and L2 is completed. It is assumed that the micro scientific apparatus 10 is always filled with the liquids L1 and L2 and the reacted reaction product liquid LM without gaps and flows to the discharge port 14 side.

  As a material of the member constituting the micro scientific device 10, a material having excellent processability, high strength, corrosion prevention, and high fluidity of the raw material fluid is preferable. For example, metal (iron, aluminum, stainless steel, titanium, other various metals), resin (fluorine resin, acrylic resin, etc.), glass (quartz etc.), ceramics (silicon etc.), etc. can be preferably used.

  In order to manufacture the micro scientific apparatus 10, a fine processing technique is applied. Applicable fine processing techniques include, for example, LIGA (Roentgen-Lithographie Galvanik Abforming) technology using X-ray lithography, high aspect ratio photolithography using EPON SU-8 (trade name), micro-discharge processing (μ) -EDM (Micro Electro Discharge Machining)), Deep RIE (Reactive Ion Etching) silicon high aspect ratio processing method, Hot Emboss processing method, stereolithography method, laser processing method, ion beam processing method, diamond-like hard There is a mechanical micro cutting method using a micro tool made of a material. These techniques may be used alone or in combination. Preferred microfabrication techniques are LIGA technology using X-ray lithography, high aspect ratio photolithography using EPON SU-8, micro-EDM (μ-EDM), and mechanical micro-cutting.

  The joining method between elements and members is preferably a precise method that keeps dimensional accuracy without causing material deterioration or deformation due to high-temperature heating, and solid phase joining (for example, It is preferable to select pressure welding, diffusion bonding, etc.) and liquid phase bonding (for example, welding, eutectic bonding, soldering, adhesion, etc.). For example, when silicon is used as the material, silicon direct bonding for bonding silicon, fusion bonding for bonding glasses, anodic bonding for bonding silicon and glass, diffusion bonding for bonding metals, and the like can be given. For bonding ceramics, bonding techniques other than mechanical sealing techniques such as metals are required. A bonding agent called glass solder is printed on alumina to a film thickness of about 80 μm without applying pressure. There is a method of heat treatment at 440-500 ° C. Further, as new technologies, there are surface activated bonding, direct bonding using hydrogen bonding, bonding using HF (hydrogen fluoride) aqueous solution, and the like.

  As the fluid supply means in the present embodiment, various micro pumps, non-pulsating plunger pumps, syringe pumps and the like can be suitably used. In these pumps, the first and third fluid supply paths and the flow paths communicating with the first and third fluid supply paths are all filled with the liquid L1, the inert liquid LN, and the liquid L2, and the entire liquid is driven by the fluid supply means prepared outside. This is a system, and the supply pressure and supply flow rate of the liquids L1 and L2 supplied to the first and third fluid supply passages are controlled stably in a non-pulsating flow especially in the case of a non-pulsating plunger pump and a syringe pump. Can do.

  Examples of the fluid used in the present embodiment include liquid, gas, liquid-solid mixed phase fluid, and gas-solid mixed phase fluid.

  Next, the operation of the micro scientific apparatus 10 of the present embodiment will be described with reference to FIGS. FIG. 3 is a diagram showing a radial cross section in the mixing / reaction channel 36.

  First, three fluid supply sources (not shown) installed on the upstream side of the micro scientific apparatus 10 in the first to third fluid supply paths 22, 24 and 26 through the fluid supply pipes 28, 30 and 32. The liquid L1, the inert liquid LN, and the liquid L2 that are in a pressurized state are supplied. At this time, for example, a method of starting the supply of the liquid L1 after starting the supply of the liquid L2 and the inert liquid LN is preferable. Thereby, it can prevent that the liquid L1 which forms non-rectification | straightening directly contacts with the liquid L2, and can suppress a nonuniform reaction or mixing.

  Next, the liquid L1 flows in the fluid supply path 22, the inert liquid LN flows in the fluid supply path 24, and the liquid L1 and the inert liquid LN merge in the correction flow path. At this time, the liquid L1 flowing out of the first fluid supply port 38 into the correction flow path 34 as non-rectifying is corrected by the action of the high-viscosity and / or high-speed liquid LN flowing on the outer periphery of the liquid L1.

  Next, the liquid (L1 + LN) whose distortion has been corrected is supplied from the second fluid supply port 40 to the mixing / reaction channel 36. The liquid L <b> 2 flows through the fluid supply channel 26 and is then supplied to the mixing / reaction channel 36. Then, the liquid (L1 + LN) and the liquid L2 merge in the mixing / reaction channel.

  At this time, as shown in FIG. 3, the liquids L1, LN, and L2 form a laminar flow in a concentric axial multi-cylindrical shape from the axial center side, and the liquids L1 and L2 mutually pass through the inert liquid LN. It can diffuse and mix or react uniformly.

  In the present embodiment, the example in which the supply of the liquid L1 and the inert liquid LN is started first and then the supply of the liquid L2 is described. However, the liquid L1, the inert liquid LN, and the liquid L2 are simultaneously supplied. May be.

  As described above, by applying the present invention, it is possible to reduce the adverse effects caused by the manufacturing accuracy of the apparatus and to uniformly react or mix a plurality of fluids in a stable laminar flow state.

  Moreover, although this embodiment demonstrated the example which makes 2 liquids react, this invention is applicable also when reacting 2 liquids or more. FIG. 4 is a diagram illustrating a radial cross section in the mixing / reaction channel when the present invention is applied to react three liquids L1, L2, and L3.

  For example, in an apparatus in which a concentric axial multilayer flow is formed and reacted in the order of the liquids L1, L2, and L3 from the axial center side, the liquid L2 is supplied from a flow path constituted by a cylindrical partition member with low manufacturing accuracy. In this case, as shown in FIG. 4, an inert liquid LN may be allowed to flow between the liquid L2 and the liquid L3.

  FIG. 5 is a cross-sectional view illustrating a modified example of the micro scientific device 10 in which the manufacturing accuracy of the first partition member 16 is low. As shown in FIG. 5, even when the manufacturing accuracy of the first partition member 16 is low, the physical properties such as the viscosity and density of the inert liquid LN flowing into the second partition member 18 and the operating conditions such as the flow rate are shown. By controlling this, the flow of the liquid L1 can be corrected.

[Second Embodiment]
This embodiment is an example in which a magnetic field is applied to the liquid L1 ′ containing a magnetic substance, and a plurality of fluids are uniformly reacted or mixed in a stable laminar flow state. FIG. 6 is a cross-sectional view illustrating an example of the configuration of the micro scientific apparatus 10 ′ according to the present embodiment. Among these, FIG. 6 (A) is an enlarged cross-sectional view of the vicinity of the joining portion of the micro scientific apparatus 10 ′, and FIG. 6 (B) is a cross-sectional view taken along the line AA ′ of FIG. 6 (A). In the figure, an example in which the manufacturing accuracy of the first partition member 16 is low is shown. In addition, in each figure, what has the same member and function as 1st embodiment attaches | subjects the same code | symbol, and the detailed description is abbreviate | omitted.

  As shown in FIG. 6, the micro scientific apparatus 10 ′ mainly excludes the second partition member 18 for supplying the liquid LN, except that a magnetic field applying means 42 for applying a magnetic field is provided outside. The configuration is almost the same as in the first embodiment.

  The material and manufacturing method of the members constituting the micro scientific apparatus 10 'are the same as in the first embodiment.

  In the present embodiment, the liquid L <b> 1 ′ is a non-rectifying liquid supplied from the inside of the first partition member 16 with low manufacturing accuracy, and contains the magnetic substance 44. The magnetic substances 44 are inactive to the liquid L1 'and the liquid L2.

  As the magnetic field applying means 42, publicly known and commonly used magnetic field applying means can be used. Specifically, various magnetic field control (applying) devices, electromagnets, various magnets, and the like can be used.

  The magnetic substance 44 may be in the form of particles dispersed in the liquid as in the present embodiment or in a state dissolved in the liquid. As a specific type of the magnetic substance 44..., Fine iron oxide (for example, EMG series manufactured by Ferrotec Co., Ltd.) or the like can be used.

  Next, the operation of the micro scientific apparatus 10 'in this embodiment will be described.

  First, through the fluid supply pipes 28 and 32, the first and third fluid supply paths 22 and 26 are added from two fluid supply sources (not shown) installed on the upstream side of the micro scientific device 10 ′. The liquids L1 ′ and L2 that are in a pressure state are supplied.

  Next, the liquid L <b> 1 ′ flows through the fluid supply path 22 and is then supplied from the first fluid supply port 38 to the mixing / reaction channel 36. The liquid L <b> 2 flows through the fluid supply channel 26 and is then supplied to the mixing / reaction channel 36. Then, the liquid L <b> 1 ′ and the liquid L <b> 2 merge in the mixing / reaction channel 36.

  At this time, the liquid L1 ′ supplied in a distorted flow state from the first fluid supply port 38 is moved in the direction of the arrow M by the magnetic substance 44... It will be corrected.

  As a result, as shown in FIG. 7, the liquids L1 ′ and L2 form a laminar flow in the form of a concentric axial multiple cylinder from the axial center side, and the liquids L1 ′ and L2 diffuse to each other and mix or react.

  As described above, by applying the present invention, it is possible to reduce the adverse effects caused by the manufacturing accuracy of the apparatus and to uniformly react or mix a plurality of fluids in a stable laminar flow state.

[Third embodiment]
This embodiment is an example in which a gravitational field is used to react or mix a plurality of fluids uniformly in a stable laminar flow state. FIG. 8 is a cross-sectional view illustrating an example of the configuration of the micro scientific apparatus 10 ″ according to the present embodiment. In the figure, an example in which the manufacturing accuracy of the first partition member 16 is low is shown. In addition, in each figure, what has the same member and function as 1st embodiment attaches | subjects the same code | symbol, and the detailed description is abbreviate | omitted.

  As shown in FIG. 8, the micro scientific device 10 ″ mainly excludes the second partition member 18 for supplying the liquid LN, except that the micro scientific device 10 ″ is tilted and fixed. The configuration is almost the same as in the first embodiment.

  The micro scientific device 10 ″ is preferably fixed by the fixing means 46 while being tilted so that gravity acts in a direction to reduce the distortion of the flow of the liquid L <b> 1 flowing in the first partition member 16. In FIG. 8, the first partition member 16 is tilted to the right in the drawing with respect to the axis of the circular tube portion 12, so that the component force G <b> 1 of gravity (arrow G) is applied to the liquid L <b> 1 flowing in the first partition member 16. Is preferably fixed so that it works in the left direction in the figure.

  The fixing means 46 may be any means as long as the micro scientific apparatus 10 ″ can be stably installed at a predetermined angle, and for example, the micro scientific apparatus 10 ″ may be fixed to a rotatable plate. . In the present embodiment, an example of the fixing means 46 having two support portions 46a and 46b is shown.

  The material and manufacturing method of the members constituting the micro scientific apparatus 10 '' are the same as in the first embodiment.

  Next, the operation of the micro scientific apparatus 10 '' in this embodiment will be described.

  First, the first and third fluid supply paths 22 and 26 are pressurized from the two fluid supply sources (not shown) installed on the upstream side of the micro scientific apparatus 10 through the fluid supply pipes 28 and 32. The liquids L1 and L2 brought into a state are supplied.

  Next, the liquid L1 flows through the fluid supply path 22 and is then supplied from the first fluid supply port 38 to the mixing / reaction channel 36. The liquid L <b> 2 flows through the fluid supply channel 26 and is then supplied to the mixing / reaction channel 36. Then, the liquid L1 and the liquid L2 merge in the mixing / reaction channel 36.

  At this time, the liquid L1 flowing out from the first fluid supply port 38 as unrectified flows under the action of gravity G and flows coaxially with the liquid L2.

  As a result, the liquids L1 and L2 form a laminar flow in the shape of a concentric axial multiple cylinder from the axial center side, and the liquids L1 'and L2 diffuse or mix with each other and react.

  As described above, by applying the present invention, it is possible to reduce the adverse effects caused by the manufacturing accuracy of the apparatus and to uniformly react or mix a plurality of fluids in a stable laminar flow state.

  As mentioned above, although embodiment of the fluid operation method of the micro scientific apparatus which concerns on this invention was described, this invention is not limited to the said embodiment, Various aspects can be taken.

  For example, in each embodiment, the example in which the fluid is a liquid has been described, but a gas may be used.

  The present invention is applicable to fluid manipulation methods in various mixing and reaction devices, various analysis devices, and the like. For example, the present invention can be applied to a fluid operation method of a fine particle production apparatus for producing fine particles such as pigment fine particles and magnetic particles such as various paints, inkjet inks, electrophotographic toners, and color filters.

It is sectional drawing of the micro scientific apparatus in 1st embodiment. It is an expanded sectional view of the micro scientific apparatus of FIG. It is a cross-sectional schematic diagram which shows the effect | action in 1st embodiment. It is a cross-sectional schematic diagram which shows the effect | action of the modification of the micro scientific apparatus in 1st embodiment. It is sectional drawing which shows the modification of the micro scientific apparatus in 1st embodiment. It is sectional drawing of the micro scientific apparatus in 2nd embodiment. It is a cross-sectional schematic diagram which shows the effect | action in 2nd embodiment. It is sectional drawing of the micro scientific apparatus in 3rd embodiment.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10, 10 ', 10''... micro scientific device, 12 ... circular pipe part, 14 ... discharge port, 16 ... 1st partition member, 18 ... 2nd partition member, 22 ... 1st fluid supply path, 24 ... 2nd Fluid supply path, 26 ... third fluid supply path, 28, 30, 32 ... fluid supply pipe, 34 ... correction flow path, 36 ... mixing / reaction flow path, 38 ... first fluid supply port, 40 ... second fluid supply Mouth, 42 ... magnetic field applying means, 44 ... magnetic substance (particle), 46 ... fixing means

Claims (7)

  A concentric multi-layer flow type micro scientific device that mixes or reacts by circulating a plurality of fluids through a single concentric multi-layer supply channel and then through a fine mixing / reaction channel. In the fluid manipulation method, the non-rectifying body that does not flow concentrically with respect to the mixing / reaction channel out of the plurality of fluids is not reacted with the plurality of fluids and is more than the plurality of fluids. A micro scientific apparatus characterized by correcting the flow of the non-rectifying body to flow in a concentric axial shape with respect to the mixing / reaction channel by flowing an inert fluid having a high flow velocity and / or high viscosity. Fluid operation method.   The flow of the non-rectifying body is corrected by flowing the inert fluid to the outside adjacent to the non-rectifying body, and then the plurality of fluids including the non-rectifying body are joined together in a multilayer shape. Fluid manipulation method for micro scientific equipment.   The fluid manipulation method for a micro scientific apparatus according to claim 1 or 2, wherein the viscosity of the inert fluid is 1 to 10 times the viscosity of the non-rectifying body.   The fluid operation method for a micro scientific apparatus according to any one of claims 1 to 3, wherein the flow rate of the inert fluid is 1 to 10 times the flow rate of the non-rectifying body.   A concentric multi-layer flow type micro scientific device that mixes or reacts by circulating a plurality of fluids through a single concentric multi-layer supply channel and then through a fine mixing / reaction channel. Among the plurality of fluids, by applying an external force to the non-rectifying body that does not flow concentrically with respect to the mixing / reaction channel, the flow of the non-rectifying body is changed to the mixing / reaction flow. A fluid manipulation method for a micro scientific device, wherein the fluid is corrected so as to flow concentrically with respect to a path.   6. The fluid manipulation method for a micro scientific apparatus according to claim 5, wherein the external force is gravity.   6. The fluid manipulation method for a micro scientific apparatus according to claim 5, wherein the non-rectifier includes a magnetic substance, and a magnetic field is applied to the non-rectifier as the external force.

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