JP2007131594A - Antibacterial composition and cosmetic and cleanser each containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an antibacterial composition which has the same or more antibacterial property as those of paraben compounds and gives excellent senses of use, and to provide a cosmetic and a cleanser which each contains the same. <P>SOLUTION: This antibacterial composition comprises a compound represented by the general formula (1) [R is a 3 to 7C alkyl; (m) and (n) are each independently an integer of 0 to 5, wherein 1≤(m)+(n)≤5], as a component (A) , and one or more kinds of compounds selected from the group consisting of chelate agents, lower mol.wt. polyols, nitrogen-containing nonionic surfactants, nitrogen-containing amphoteric surfactants, plant-originated extracts and zinc compounds as a component (B). A cosmetic and a cleanser each comprises the same. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an antibacterial composition, and a cosmetic and a cleaning agent containing the same, and more specifically, an antibacterial composition that enhances the antibacterial property of a specific alkanediol derivative and has an excellent feeling of use, and the same. It relates to cosmetics and cleaning agents.

  Antibacterial agents are often used in cosmetics and cleaning agents for the purpose of preserving. Parabens are most commonly used as these antibacterial agents, but parabens have a drawback that the concentration range of use is limited because of their high skin irritation and low safety. Therefore, in cosmetics, the use concentration of parabens is limited to 1% or less. Recently, an increasing number of people have an allergic reaction to parabens, and the demand for cosmetics not containing parabens has increased.

As antibacterial agents other than parabens, alkanediols and alkyl glyceryl ethers (for example, see Patent Documents 1 and 2), alkanediol (mono, di, tri) ethylene glycol ethers (for example, see Patent Document 3) ) Etc. are known.
JP-A-11-322591 (Claims etc.) JP 51-76424 (Claims etc.) JP-A-54-49322 (Claims etc.)

  However, alkanediols and alkyl glyceryl ethers have higher safety to the human body than parabens, but when actually used as cosmetics, some people feel that the feeling of use is poor. In addition, alkanediol (mono, di, tri) ethylene glycol ethers have a weak antibacterial property, and there is a problem that a desired antibacterial property cannot be obtained unless a large amount is used. In addition, it has not been known that there are compounds that improve antibacterial properties when used in combination.

  Accordingly, an object of the present invention is to provide an antibacterial composition having an antibacterial property equivalent to or higher than that of parabens and having an excellent usability, and a cosmetic and a cleaning agent containing the same.

  As a result of intensive studies to solve the above problems, the present inventors have found that an antibacterial composition having high safety and antibacterial properties can be obtained by combining specific compounds, and the present invention has been completed.

（式中、Ｒは炭素数３〜７のアルキル基、ｍおよびｎはそれぞれ独立に０〜５の整数であり、１≦ｍ＋ｎ≦５である）で表される化合物と、
（Ｂ）成分として、キレート剤、低分子ポリオール、窒素含有ノニオン界面活性剤、窒素含有両性界面活性剤、植物由来エキスおよび亜鉛化合物からなる群から選択される１種または２種以上の化合物と、を含有することを特徴とするものである。 That is, the antibacterial composition of the present invention has the following general formula (1) as component (A):

Wherein R is an alkyl group having 3 to 7 carbon atoms, m and n are each independently an integer of 0 to 5, and 1 ≦ m + n ≦ 5,
As the component (B), one or more compounds selected from the group consisting of a chelating agent, a low molecular polyol, a nitrogen-containing nonionic surfactant, a nitrogen-containing amphoteric surfactant, a plant-derived extract, and a zinc compound; It is characterized by containing.

  The cosmetic of the present invention is characterized by containing the antibacterial composition of the present invention, and the cleaning agent of the present invention contains the antibacterial composition of the present invention. To do.

  According to the present invention, it is possible to provide an antibacterial composition having high antibacterial properties equivalent to or higher than parabens, which is highly safe for the human body and can be used for people with sensitive skin. Therefore, it is extremely useful as an antibacterial agent for cosmetics and cleaning agents.

で表される化合物を含有する。ここで、Ｒは炭素数３〜７のアルキル基であり、例えば、プロピル基、ブチル基、イソブチル基、２級ブチル基、ターシャリブチル基、ペンチル基、イソペンチル基、２級ペンチル基、ネオペンチル基、ターシャリペンチル基、ヘキシル基、２級ヘキシル基、ヘプチル基、２級ヘプチル基等が挙げられる。 Hereinafter, preferred embodiments of the present invention will be described.
The antibacterial composition of the present invention has the following general formula (1) as component (A),

The compound represented by these is contained. Here, R is an alkyl group having 3 to 7 carbon atoms, for example, propyl group, butyl group, isobutyl group, secondary butyl group, tertiary butyl group, pentyl group, isopentyl group, secondary pentyl group, neopentyl group. , Tertiary pentyl group, hexyl group, secondary hexyl group, heptyl group, secondary heptyl group and the like.

  Among these alkyl groups, an alkyl group having 4 to 6 carbon atoms is preferable, and an alkyl group having 5 carbon atoms is more preferable because of good antibacterial properties. In addition, a linear alkyl group is more preferable than a branched alkyl group because of good antibacterial properties. When the carbon number of R is less than 3, the antibacterial property is weak, so it cannot withstand actual use. When the carbon number exceeds 7, the antibacterial property is weakened, and the solubility in water becomes poor. Since it becomes difficult to mix | blend with the product of aqueous solution, it is unpreferable.

  m and n are each independently an integer of 0 to 5, and since the antibacterial property becomes strong, the number of 1 to 3 is preferable, and 1 is more preferable. When m and n are larger than 5, the antibacterial property becomes weak and cannot be used in actual use. Further, 1 ≦ m + n ≦ 5, and the sum of m and n is preferably an integer of 1 to 3, and more preferably 1, since the antibacterial property becomes strong.

  As a method for producing the compound represented by the general formula (1), for example, a method of reacting a 1,2-epoxy compound such as α-olefin oxide with a glycol compound such as ethylene glycol or diethylene glycol, or 1,2- A method of reacting 1,2-diol compound such as alkanediol with ethylene oxide, a method of dehydrating condensation of glycol compound such as ethylene glycol to 1,2-diol compound such as 1,2-alkanediol, 1,2-alkanediol, etc. And a method of reacting a 1,2-diol compound such as 2-chloro-1-ethanol with a halogenated compound. Among these, it is preferable to produce by a method using a 1,2-epoxy compound or ethylene oxide because the reaction is easy and the post-treatment can be easily performed. These may be purified and isolated by a method such as recrystallization or distillation, or may be used as a mixture as it is. The 1,2-epoxy compound can be obtained by oxidizing the terminal olefin compound with an oxidizing agent such as hydrogen peroxide.

  When a 1,2-epoxy compound is reacted with a glycol compound, or when a 1,2-diol compound is reacted with ethylene oxide, it may be reacted without a catalyst, but must be reacted at a high temperature of 200 ° C. or higher. The condensation reaction between polyols may occur. Therefore, it is preferable to use a catalyst to lower the reaction temperature. Examples of catalysts include mineral acids such as sulfuric acid, hydrochloric acid, nitric acid and phosphoric acid; sulfonic acid compounds such as methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid and m-xylenesulfonic acid; boron trifluoride and tin chloride Lewis acids such as iron chloride; alkali metal hydroxides such as lithium hydroxide, sodium hydroxide, potassium hydroxide, rubidium hydroxide, cesium hydroxide; trimethylamine, triethylamine, tributylamine, N, N, N ′, N ′ -Tetramethyl-1,2-ethylenediamine, N, N, N ′, N′-tetraethyl-1,2-ethylenediamine, N, N, N ′, N′-tetramethyl-1,6-hexanediamine, etc. 3 amine compounds; tetramethylammonium hydride, tetraethylammonium hydride, tetrabutylammonium Ammonium hydride such as Idoraido like. Moreover, you may use simultaneously the solvent which does not inhibit reactions, such as toluene and hexane.

  As a specific reaction method using a catalyst, for example, in the case of an acid catalyst, 0.001 to 5 mass% is added to the reaction system, and the reaction is performed at a reaction temperature of 10 to 90 ° C. for 1 to 5 hours. What is necessary is just to remove a catalyst, and in the case of an alkali catalyst, 0.001-5 mass% is added with respect to a reaction system, it reacts at reaction temperature 100-180 degreeC for 2 to 20 hours, and what is necessary is just to remove a catalyst at the end.

  The amount of the component (A) used in the present invention varies depending on the application to be used and is not particularly limited. However, if it is too small, the antibacterial effect may be low, and if it is too large, an effect of increasing the amount corresponding to the amount added can be obtained. Since it may not exist, 0.001-20 mass% is preferable with respect to the whole composition, 0.01-5 mass% is more preferable, 0.1-2 mass% is still more preferable. Moreover, when using 2 or more types of (A) component, it is preferable that the total compounding quantity becomes said range.

  The antibacterial composition of the present invention is selected from the group consisting of a chelating agent, a low molecular polyol, a nitrogen-containing nonionic surfactant, a nitrogen-containing amphoteric surfactant, a plant-derived extract, and a zinc compound as the component (B). Containing one or more compounds.

  Examples of chelating agents include aminopolycarboxylic acid chelating agents, aromatic or aliphatic carboxylic acid chelating agents, amino acid chelating agents, ether polycarboxylic acid chelating agents, phosphonic acid chelating agents, phosphoric acid chelating agents, Examples include hydroxycarboxylic acid chelating agents, polymer electrolyte (including oligomer electrolyte) chelating agents, dimethylglyoxime, ascorbic acid, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxalic acid. These chelating agents may be in the free acid form or in the form of a salt such as sodium salt, potassium salt, or ammonium salt. Furthermore, they may be in the form of their ester derivatives which are hydrolysable.

  Examples of the aminopolycarboxylic acid chelating agent include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, N- (2 -Hydroxyethyl) ethylenediaminetriacetic acid, glycol etherdiaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid and their salts.

  Examples of aromatic or aliphatic carboxylic acid chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvic acid, salicylic acid, Acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranilic acid), phthalic acid, trimellitic acid, gallic acid, hexahydrophthalic acid, fumaric acid and their salts, methyl esters and ethyl esters.

  Examples of the amino acid chelating agent include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts and derivatives thereof.

  Examples of the hydroxycarboxylic acid chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid, and salts thereof.

  Examples of the phosphonic acid chelating agent include iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.

  Examples of the phosphoric acid chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, and polyphosphoric acid.

  Examples of the polymer electrolyte (including oligomer electrolyte) chelating agent include acrylic acid polymer, maleic anhydride polymer, α-hydroxyacrylic acid polymer, itaconic acid polymer, and two constituent monomers of these polymers. The copolymer which consists of the above and an epoxy succinic acid polymer are mentioned.

  Among these chelating agents, ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid, succinic acid, salicylic acid, oxalic acid, lactic acid , Fumaric acid, citric acid, tartaric acid, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof are preferred, ethylenediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, glutamic acid di Acetic acid, aspartic acid diacetic acid, succinic acid, lactic acid, tartaric acid and salts thereof are more preferred, and ethylenediaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid and salts thereof are more preferred.

  The blending amount of the chelating agent is not particularly limited, but if the chelating agent is too small, the antibacterial improvement effect may not be obtained. Further, when the amount of the chelating agent is increased, the antibacterial property is improved accordingly, but when the chelating agent exceeds a certain amount, the antibacterial property may not be further improved. Therefore, 0.5-500 mass parts is preferable with respect to 100 mass parts of (A) component, as for a chelating agent, 1-200 mass parts is more preferable, and 2-50 mass parts is still more preferable. If the content of the chelating agent is less than 0.5 parts by mass, the antibacterial improvement effect due to the addition of the chelating agent may not be sufficiently obtained, and if it exceeds 500 parts by mass, the antibacterial properties can be further improved. It may disappear. Moreover, when using 2 or more types of chelating agents, it is preferable that the total compounding quantity becomes said range.

  Examples of the low molecular polyol include ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3-propanediol, 1,2-butanediol, 1,3- Butanediol, 1,4-butanediol, 2,3-butanediol, 2-methyl-1,2-propanediol, 2-methyl-1,3-propanediol, 1,2-pentanediol, 1,3- Pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2-methyl-1,2-butanediol, 2-methyl-2,3- Butanediol, 2-methyl-1,4-butanediol, 3-methyl Ru-1,2-butanediol, 3-methyl-1,3-butanediol, 2-ethyl-1,3-propanediol, 2,2-dimethyl-1,3-propanediol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, 2,5-hexanediol, 3,3-hexanediol, 2-methyl-1,3-pentanediol, 2-methyl-1,5-pentanediol, 2-methyl-2,4-pentanediol, 3-methyl-1,5-pentanediol, 3-methyl-2,3-pentanediol, 3-methyl-2,4-pentanediol, 4-methyl-1, 2-pentanediol, 2-ethyl-2-methyl-1,3-propanediol, 2,2-dimethyl-2,4-butanediol, 2,3-dimethyl-1,2-butane All, 1,2-heptanediol, 1,7-heptanediol, 3,4-heptanediol, 2-propyl-2-methyl-1,3-propanediol, 2-isopropyl-2-methyl-1,3- Propanediol, 1,2-octanediol, 1,8-octanediol, 3,6-octanediol, 2-ethyl-1,3-hexanediol, 2-sec-butyl-2-butyl-1,3-propane Diol, 2,2-dimethyl-1,3-hexanediol, 2,5-dimethyl-2,5-hexanediol, 2,2,4-trimethyl-1,3-pentanediol, 1,2-nonanediol, 1,3-nonanediol, 1,9-nonanediol, 3,6-octanediol, 2-ethyl-2- (2-methyl) propyl-1,3-propanedioe 2,2,4-trimethyl-1,6-hexanediol, 2,4,4-trimethyl-1,6-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 2,4 -Diethyl-1,5-pentanediol, 2-methyl-1,8-octanediol, 1,2-decanediol, 1,10-decanediol, 5,6-decanediol, 3,6-dimethyl-3, 6-octanediol, 3,7-dimethyl-1,6-octanediol, 3,7-dimethyl-1,7-octanediol, 1,2-undecanediol, 1,4-undecanediol, 1,11-undecane Diol, 6-ethyl-3-methyl-1,6-octanediol, 1,2-dodecanediol, 1,10-dodecanediol, 1,12-dodecanediol, 2,4 Diethyl-1,5-octanediol, 2,8,8-trimethyl-2,7-nonanediol, 1,2-tetradecanediol, 1,14-tetradecanediol, 7,8-tetradecanediol, 1,2-pentadecane Diol, 1,2-hexadecanediol, 1,16-hexadecanediol, 1,17-heptadecanediol, 1,2-octadecanediol, 1,12-octadecanediol, 1,2-eicosanediol, 1,2- Examples thereof include saturated diols such as docosanediol and 1,2-tetracosanediol or condensates thereof.

  2-butene-1,4-diol, 3-butene-1,2-diol, 2-methylene-1,3-propanediol, 2-butyne-1,4-diol, 5-hexene-1,2 -Diol, 3-methyl-2-pentene-1,5-diol, 3-methylenepentane-1,5-diol, 1,5-hexadiene-3,4-diol, 7-octene-1,2-diol, 2,5-dimethyl-3-hexene-2,5-diol, 9-decene-1,2-diol, 2,6-dimethyl-7-octene-2,6-diol, 3,7-dimethyl-7- Octene-1,6-diol, 13-tetradecene-1, 2-diol, 12-hydroxy-9-octadecenol, 2-pentyne-1,4-diol, 3-hexyne-2,5-diol, 4-methyl- 2-pen 1,4-diol, 3-heptin-2,5-diol, 4-methyl-2-pentyne-1,4-diol, 3,4-dimethyl-1-pentyne-3,4-diol, 2, 5-dimethyl-3-hexyne-2,5-diol, 5-decyne-4,7-diol, 2,6-dimethyl-7-octyne-2,6-diol, 3,6-dimethyl-4-octyne- 3,6-diol, 2,3,6,7-tetramethyl-4-octyne-3,6-diol, 2,4,7,9-tetramethyl-5-decyne-4,7-diol, 2, 5,8,11-tetramethyl-6-dodecin-5,8-diol, 1,1,4,4-tetraisopropyl-4-octyne-3,6-diol, 5,10-diethyl-7-tetradecine- And unsaturated diols such as 6,9-diol .

  Further, 1,2-cyclopentanediol, 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2-cycloheptanediol, 2,3 -Norbornanediol, 2,5-norbornanediol, 2,7-norbornanediol, 1,2-cyclooctanediol, 1,4-cyclooctanediol, 1,2-cyclodecanediol, 5-cyclooctene-1,2 Examples thereof include alicyclic diols such as diol, 1,5-decalin diol, limonene glycol, 1,2-terpene diol, 4,4′-bicyclohexane diol, and 1,2-cyclododecane diol.

  Furthermore, glycerin, 1,2,3-butanetriol, 1,2,4-butanetriol, 2-methyl-1,2,3-propanetriol, 1,2,3-pentanetriol, 1,2,4 -Pentanetriol, 1,3,5-pentanetriol, 2,3,4-pentanetriol, 2-methyl-2,3,4-butanetriol, trimethylolethane, 2,3,4-hexanetriol, 2- Ethyl-1,2,3-butanetriol, trimethylolpropane, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl-2,3,4-pentanetriol, triethanolamine, triisopropanolamine And trihydric alcohols such as

  Furthermore, erythritol, pentaerythritol, 1,2,3,4-pentatetrol, 2,3,4,5-hexatetrol, 1,2,4,5-pentanetetrol, 1,3,4, Tetravalent such as 5-hexanetetrol, diglycerin, sorbitan, N, N, N ′, N′-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N ′, N′-tetrakis (hydroxyethyl) ethylenediamine Also includes alcohol.

  Furthermore, pentahydric alcohols such as adonitol, arabitol, xylitol, and triglycerin are also included.

  Furthermore, hexavalent alcohols such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose, and allose are also included.

  Furthermore, 1-methyl glyceryl ether, 2-methyl glyceryl ether, 1-ethyl glyceryl ether, 2-ethyl glyceryl ether, 1-propyl glyceryl ether, 2-propyl glyceryl ether, 1-isopropyl glyceryl ether, 2-isopropyl glyceryl ether 1-butyl glyceryl ether, 2-butyl glyceryl ether, 1-isobutyl glyceryl ether, 2-isobutyl glyceryl ether, 1-pentyl glyceryl ether, 2-pentyl glyceryl ether, 1-hexyl glyceryl ether, 2-hexyl glyceryl ether, 1 -Heptyl glyceryl ether, 2-heptyl glyceryl ether, 1-octyl glyceryl ether, 2-octyl glyceryl ether, 1- (2-ethyl Xyl) glyceryl ether, 2- (2-ethylhexyl) glyceryl ether, 1-nonyl glyceryl ether, 2-nonyl glyceryl ether, 1-decyl glyceryl ether, 2-decyl glyceryl ether, 1-undecyl glyceryl ether, 2-undecyl Glyceryl ether, 1-dodecyl glyceryl ether, 2-dodecyl glyceryl ether, 1-tridecyl glyceryl ether, 2-tridecyl glyceryl ether, 1-tetradecyl glyceryl ether, 2-tetradecyl glyceryl ether, 1-hexadecyl glyceryl ether, 2-hexadecyl glyceryl ether, 1-octadecyl glyceryl ether, 2-octadecyl glyceryl ether, 1-branched octadecyl glyceryl ether, 2-branched octa Silglyceryl ether, 1-eicosyl glyceryl ether, 2-eicosyl glyceryl ether, 1-allyl glyceryl ether, 2-allyl glyceryl ether, 1-undecenyl glyceryl ether, 2-undecenyl glyceryl ether, 1-oleyl glyceryl Also included are glycerin monoethers such as ether, 2-oleyl glyceryl ether, 1-cyclohexyl glyceryl ether, 2-cyclohexyl glyceryl ether, 1-phenyl glyceryl ether, 2-phenyl glyceryl ether.

  Furthermore, N-substituted diethanolamines such as N-methyldiethanolamine, N-ethyldiethanolamine, N-propyldiethanolamine, N-isopropyldiethanolamine, N-butyldiethanolamine, N-cyclohexyldiethanolamine, N- (2-ethylhexyl) diethanolamine are also exemplified. It is done.

  Furthermore, N-methyldiisopropanolamine, N-ethyldiisopropanolamine, N-propyldiisopropanolamine, N-isopropyldiisopropanolamine, N-butyldiisopropanolamine, N-cyclohexyldiisopropanolamine, N- (2- N-substituted diisopropanolamines such as ethylhexyl) diisopropanolamine are also included.

  Furthermore, 3-dimethylamino-1,2-propanediol, 3-diethylamino-1,2-propanediol, 3-dipropylamino-1,2-propanediol, 3-diisopropylamino-1,2-propanediol And N, N-disubstituted-3-amino-1,2-propanediols such as 3-dibutylamino-1,2-propanediol.

  Among these low molecular polyols, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 1 , 2-pentanediol, 3-methyl-1,3-butanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 2-ethyl-1,3-hexanediol, 1, 2-nonanediol, 2-butyl-2-ethyl-1,3-propanediol, 1,2-decanediol, 1,10-decanediol, glycerin, triethanolamine, triisopropanolamine, erythritol, diglycerin, sorbitan , N, N, N ′, N ′ Tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N ′, N′-tetrakis (hydroxyethyl) ethylenediamine, sorbitol, 1-methylglyceryl ether, 1-ethylglyceryl ether, 1-propylglyceryl ether, 1-butylglyceryl Ether, 1-octyl glyceryl ether, 1- (2-ethylhexyl) glyceryl ether, 1-decyl glyceryl ether, 1-allyl glyceryl ether are preferred, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tri Propylene glycol, 1,3-butanediol, 3-methyl-1,3-butanediol, 1,2-octanediol, glycerin, triethanolamine, di- More preferred are lysine, sorbitan, N, N, N ′, N′-tetrakis (2-hydroxypropyl) ethylenediamine, sorbitol, 1-allylglyceryl ether, propylene glycol, dipropylene glycol, 1,3-butanediol, 3- More preferred are methyl-1,3-butanediol, glycerin, sorbitol, and 1-allyl glyceryl ether.

  The blending amount of the low molecular polyol is not particularly limited, but if the low molecular polyol is too small, the antibacterial improvement effect may not be obtained. Further, when the amount of the low molecular polyol is increased, the antibacterial property is improved accordingly, but when the amount of the low molecular polyol exceeds a certain amount, the antibacterial property may not be further improved. Therefore, 0.5-500 mass parts is preferable with respect to 100 mass parts of (A) component, as for a low molecular polyol, 1-200 mass parts is more preferable, and 2-50 mass parts is still more preferable. If the content of the low molecular polyol is less than 0.5 parts by mass, the antibacterial effect may not be sufficiently obtained by the addition of the low molecular polyol. If the content exceeds 500 parts by mass, the antibacterial property is further improved. May not be possible. Moreover, when using 2 or more types of low molecular polyols, it is preferable that the total compounding quantity becomes said range.

上記式中、Ｒ¹はアルキル基またはアルケニル基を表し、Ｒ²はアルキル基、アルケニル基または−（ＣＨ₂−ＣＨ₂Ｏ）_XＨで表される基を表し、ａおよびＸはそれぞれ独立に１〜２０の整数を表す。Ｒ¹は炭素数８〜２２が好ましく、炭素数１２〜１８がより好ましい。また、Ｒ²は−（ＣＨ₂−ＣＨ₂Ｏ）_XＨで表される基が好ましい。更に、ａとＸとの合計の値が２〜１０の整数であることが好ましく、２〜４の整数であることがより好ましい。 Examples of the nitrogen-containing nonionic surfactant include compounds having a structure represented by the following general formulas (2) to (8).

In the above formula, R ¹ represents an alkyl group or an alkenyl group, R ² represents an alkyl group, an alkenyl group or a group represented by — (CH ₂ —CH ₂ O) _X H, and a and X are each independently The integer of 1-20 is represented. R ¹ preferably has 8 to 22 carbon atoms, and more preferably 12 to 18 carbon atoms. R ² is preferably a group represented by — (CH ₂ —CH ₂ O) _X H. Furthermore, the total value of a and X is preferably an integer of 2 to 10, and more preferably an integer of 2 to 4.

上記式中、Ｒ³はアルキル基またはアルケニル基を表し、Ｒ⁴は炭素数２〜６のアルキレン基を表し、ｂ、ｃ、およびｄはそれぞれ独立に１〜２０の整数を表す。Ｒ³は炭素数８〜２２が好ましく、炭素数１２〜１８がより好ましい。また、Ｒ⁴は炭素数２〜３が好ましく、炭素数３がより好ましい。更に、ｂ、ｃ、ｄの合計の値が３〜１０の整数であることが好ましく、３〜５の整数であることがより好ましい。

In the above formula, R ³ represents an alkyl or alkenyl group, R ⁴ represents an alkylene group having 2 to 6 carbon atoms, b, c, and d each independently represent an integer of 1-20. R ³ preferably has 8 to 22 carbon atoms, and more preferably 12 to 18 carbon atoms. R ⁴ preferably has 2 to 3 carbon atoms, and more preferably 3 carbon atoms. Furthermore, the total value of b, c and d is preferably an integer of 3 to 10, and more preferably an integer of 3 to 5.

上記式中、Ｒ⁵はアルキル基またはアルケニル基を表す。Ｒ⁵は炭素数８〜２２が好ましく、炭素数９〜１８がより好ましく、炭素数１０〜１４が更に好ましい。

In the above formula, R ⁵ represents an alkyl group or an alkenyl group. R ⁵ preferably has 8 to 22 carbon atoms, more preferably 9 to 18 carbon atoms, and still more preferably 10 to 14 carbon atoms.

上記式中、Ｒ⁶はアルキル基またはアルケニル基を表し、Ｒ⁷は水素原子、炭素数１〜４のアルキル基または−（Ｚ²Ｏ）_yＨで表される基を表し、Ｚ¹およびＺ²はそれぞれ独立に炭素数２〜３のアルキレン基を表し、ｅおよびｙはそれぞれ独立に１〜２０の整数を表す。Ｒ⁶は炭素数８〜２２が好ましく、炭素数９〜１８がより好ましく、炭素数１０〜１４が更に好ましい。また、Ｒ⁷は水素原子、メチル基、−ＣＨ₂−ＣＨ₂ＯＨが好ましく、水素原子、メチル基がより好ましい。更に、Ｒ⁷が水素原子の場合、ｅは１〜３の数が好ましく、Ｚ¹がエチレン基でｅが１であることがより好ましい。Ｒ⁷がメチル基の場合、Ｚ¹がエチレン基であることが好ましく、Ｚ¹がエチレン基でｅが１であることがより好ましい。Ｒ⁷が−ＣＨ₂−ＣＨ₂ＯＨの場合は、Ｚ¹がエチレン基でｅが１であることが好ましい。

In the above formula, R ⁶ represents an alkyl group or an alkenyl group, R ⁷ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by — (Z ² O) _y H, and Z ¹ and Z ² independently represents an alkylene group having 2 to 3 carbon atoms, and e and y each independently represents an integer of 1 to 20. R ⁶ preferably has 8 to 22 carbon atoms, more preferably 9 to 18 carbon atoms, and still more preferably 10 to 14 carbon atoms. R ⁷ is preferably a hydrogen atom, a methyl group, or —CH ₂ —CH ₂ OH, more preferably a hydrogen atom or a methyl group. Further, when R ⁷ is a hydrogen atom, e is preferably a number from 1 to 3, more preferably Z ¹ is an ethylene group and e is 1. When R ⁷ is a methyl group, Z ¹ is preferably an ethylene group, more preferably Z ¹ is an ethylene group and e is 1. When R ⁷ is —CH ₂ —CH ₂ OH, it is preferable that Z ¹ is an ethylene group and e is 1.

上記式中、Ｚ³およびＺ⁴はそれぞれ独立にエチレン基またはプロピレン基を表し、ｆ〜ｌおよびｏはそれぞれ独立に１〜２００の整数を表す。ただし、Ｚ³およびＺ⁴が同じ基になることはない。Ｚ³がプロピレン基でＺ⁴がエチレン基であることが好ましい。また、ｆ、ｈ、ｊ、ｌの合計の値が３０〜７０であることが好ましく、４０〜５５がより好ましく、４５〜５０が更に好ましい。更に、ｇ、ｉ、ｋ、ｏの合計の値が、ｆ、ｈ、ｊ、ｌの合計の値に対して、１０〜２００％であることが好ましく、２０〜１５０％であることがより好ましく、５０〜１００％であることが更に好ましい。

In the above formula, Z ³ and Z ⁴ each independently represent an ethylene group or a propylene group, and f to l and o each independently represents an integer of 1 to 200. However, Z ³ and Z ⁴ are not the same group. It is preferable that Z ³ is a propylene group and Z ⁴ is an ethylene group. The total value of f, h, j, and l is preferably 30 to 70, more preferably 40 to 55, and still more preferably 45 to 50. Furthermore, the total value of g, i, k, o is preferably 10 to 200%, more preferably 20 to 150% with respect to the total value of f, h, j, and l. 50 to 100% is more preferable.

上記式中、Ｒ⁸は炭素数８〜１８のアルキル基を表す。Ｒ⁸は炭素数９〜１８が好ましく、炭素数１０〜１６がより好ましく、炭素数１０〜１４が更に好ましい。

In the above formula, R ⁸ represents an alkyl group having 8 to 18 carbon atoms. R ⁸ preferably has 9 to 18 carbon atoms, more preferably 10 to 16 carbon atoms, and still more preferably 10 to 14 carbon atoms.

上記式中、Ｒ⁹は炭素数７〜２１のアルキル基を表す。Ｒ⁹は炭素数８〜１７が好ましく、炭素数９〜１５がより好ましく、炭素数９〜１３が更に好ましい。

In the above formula, R ⁹ represents an alkyl group having 7 to 21 carbon atoms. R ⁹ preferably has 8 to 17 carbon atoms, more preferably 9 to 15 carbon atoms, and still more preferably 9 to 13 carbon atoms.

  Among these nitrogen-containing nonionic surfactants, compounds represented by the general formulas (2), (4), (5), (7), and (8) are preferable, and the general formulas (4), (5), (8) is more preferable, and general formula (5) is most preferable.

  Although the compounding quantity of nitrogen-containing nonionic surfactant is not specifically limited, If there are too few nitrogen-containing nonionic surfactants, an antibacterial improvement effect may not be acquired. Further, when the amount of the nitrogen-containing nonionic surfactant is increased, the antibacterial property is improved accordingly, but when the amount of the nitrogen-containing nonionic surfactant exceeds a certain amount, the antibacterial property may not be further improved. Therefore, 0.5-500 mass parts is preferable with respect to 100 mass parts of (A) component, as for a nitrogen-containing nonionic surfactant, 1-200 mass parts is more preferable, and 2-50 mass parts is still more preferable. If the content of the nitrogen-containing nonionic surfactant is less than 0.5 parts by mass, the antibacterial improvement effect due to the addition of the nitrogen-containing nonionic surfactant may not be sufficiently obtained. May not be able to improve further. Moreover, when using 2 or more types of nitrogen-containing nonionic surfactant, it is preferable that the total compounding quantity becomes said range.

上記式中、Ｒ¹⁰は炭素数８〜２２のアルキル基を表し、ｐは１〜３の整数を表す。Ｒ¹⁰は炭素数９〜１８が好ましく、炭素数１０〜１６がより好ましく、炭素数１０〜１４が更に好ましい。また、ｐの値は１が好ましい。 Examples of the nitrogen-containing amphoteric surfactant include compounds having a structure represented by the following general formulas (9) to (14).

In the above formula, R ¹⁰ represents an alkyl group having 8 to 22 carbon atoms, and p represents an integer of 1 to 3. R ¹⁰ preferably has 9 to 18 carbon atoms, more preferably 10 to 16 carbon atoms, and still more preferably 10 to 14 carbon atoms. The value of p is preferably 1.

上記式中、Ｒ¹¹は炭素数７〜２１のアルキル基またはアルケニル基を表し、ｑは２〜３の整数を表す。Ｒ¹¹は炭素数８〜１７が好ましく、炭素数９〜１５がより好ましく、炭素数９〜１３が更に好ましい。また、ｑの値は３が好ましい。

In the above formula, R ¹¹ represents an alkyl group or alkenyl group having 7 to 21 carbon atoms, and q represents an integer of 2 to 3. R ¹¹ preferably has 8 to 17 carbon atoms, more preferably 9 to 15 carbon atoms, and still more preferably 9 to 13 carbon atoms. The value of q is preferably 3.

上記式中、Ｒ¹²は炭素数７〜２１のアルキル基またはアルケニル基を表し、ｒは２〜３の整数を表す。Ｒ¹²は炭素数８〜１７が好ましく、炭素数９〜１５がより好ましく、炭素数９〜１３が更に好ましい。また、ｒの値は３が好ましい。

In the above formula, R ¹² represents an alkyl group or alkenyl group having 7 to 21 carbon atoms, and r represents an integer of 2 to 3. R ¹² preferably has 8 to 17 carbon atoms, more preferably 9 to 15 carbon atoms, and still more preferably 9 to 13 carbon atoms. The value of r is preferably 3.

上記式中、Ｒ¹³は炭素数７〜２１のアルキル基またはアルケニル基を表す。Ｒ¹³は炭素数８〜１７が好ましく、炭素数９〜１５がより好ましく、炭素数９〜１３が更に好ましい。

In the above formula, R ¹³ represents an alkyl group or alkenyl group having 7 to ²¹ carbon atoms. R ¹³ preferably has 8 to 17 carbon atoms, more preferably 9 to 15 carbon atoms, and still more preferably 9 to 13 carbon atoms.

上記式中、Ｒ¹⁴は炭素数８〜２２のアルキル基またはアルケニル基を表し、ｓは２〜３の整数を表す。Ｒ¹⁴は炭素数９〜１８が好ましく、炭素数１０〜１６がより好ましく、炭素数１０〜１４が更に好ましい。また、ｓの値は３が好ましい。

In the above formula, R ¹⁴ represents an alkyl group or alkenyl group having 8 to 22 carbon atoms, and s represents an integer of 2 to 3. R ¹⁴ preferably has 9 to 18 carbon atoms, more preferably 10 to 16 carbon atoms, and still more preferably 10 to 14 carbon atoms. The value of s is preferably 3.

上記式中、Ｒ¹⁵は炭素数７〜２１のアルキル基またはアルケニル基を表し、ｔは２〜３の整数を表す。Ｒ¹⁵は炭素数８〜１７が好ましく、炭素数９〜１５がより好ましく、炭素数９〜１３が更に好ましい。また、ｔの値は３が好ましい。

In the above formula, R ¹⁵ represents an alkyl group or alkenyl group having 7 to 21 carbon atoms, and t represents an integer of 2 to 3. R ¹⁵ preferably has 8 to 17 carbon atoms, more preferably 9 to 15 carbon atoms, and still more preferably 9 to 13 carbon atoms. The value of t is preferably 3.

  Among these nitrogen-containing amphoteric surfactants, compounds represented by general formulas (9), (10), and (11) are preferable, general formulas (10) and (11) are more preferable, and general formula (10) Is most preferred.

  Although the compounding quantity of nitrogen-containing amphoteric surfactant is not specifically limited, If there are too few nitrogen-containing amphoteric surfactants, an antibacterial improvement effect may not be acquired. Further, when the amount of the nitrogen-containing amphoteric surfactant is increased, the antibacterial property is improved accordingly, but when the nitrogen-containing amphoteric surfactant exceeds a certain amount, the antibacterial property may not be further improved. Therefore, 0.5-500 mass parts is preferable with respect to 100 mass parts of (A) component, and nitrogen-containing amphoteric surfactant has more preferable 1-200 mass parts, and 2-50 mass parts is still more preferable. If the content of the nitrogen-containing amphoteric surfactant is less than 0.5 parts by mass, the antibacterial improvement effect due to the addition of the nitrogen-containing amphoteric surfactant may not be sufficiently obtained. May not be able to improve further. Moreover, when using 2 or more types of nitrogen-containing amphoteric surfactant, it is preferable that the total compounding quantity becomes said range.

  The plant-derived extract, which is the component (B) of the antibacterial composition of the present invention, refers to all plants, algae or fungi, or specific sites such as flowers, leaves, stems, fruits, bark, roots, seeds, and resins. It can be obtained as it is or after being compressed, dried, pulverized or fermented, and then extracted with a solvent at room temperature or under heating, and is soluble in water, ethanol, propylene glycol or oils. Alternatively, the extract may be diluted, concentrated or dried. Further, it may be an essential oil obtained by using a steam distillation method, an extraction method, a chromatography method or the like.

  As an extraction solvent, those usually used for extraction of natural product components, such as water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as ethylene glycol, propylene glycol, butylene glycol and glycerin; acetone and methyl ethyl ketone Ketones such as methyl acetate and ethyl acetate; ethers such as tetrahydrofuran, diethyl ether and polyethylene glycol; halogenated hydrocarbons such as dichloroethane and chloroform; aliphatics such as petroleum ether, n-hexane and cyclohexane Hydrocarbons; aromatic hydrocarbons such as toluene; pyridines; sodium chloride solution, and the like. Water, ethanol, propylene glycol, and butylene glycol are particularly preferable.

Plants that can be used as plant-derived extracts include, for example, arch chalk, almond, eye, Aisenhard thia polystacia, eyebright, blue-green agave, aomoji, acacia concina, acacia senegal, acacia senegal gum, acacia decreens, red clover, Akaharunire, Akayamajiou, Agi, Agrimonia eupatoria, Akebobi, Asagaokakaraksa, thistle, reed, ashitaba, ajugatsu kestanika, azuki, asunaro, asparagus, asparagus sine alice, acerola, asenayaku, asenayakashi, atlas Gaith Suleio Calps, Avenas Trigosa, Avocado, Ama, Amacha, Amacharu, Amadokoro, Amamo, Amiris Balsamifera, American Pikachi, America Shaw, American Shaw, American Carrot, Amomu Aromachiku, Aracasi, Arcana, Arctium Majus, Arctium Minus, Arnica, Arnica Mythonis, Alpinia Officinalum, Alfalfa (Acacia palma), Aloe Vera, Ansange, Apricot, Angelica, Antilis Brunellaria, Amperopsis Grocedentata, Anmarok, Ikarisou, Izayoi Rose, Itadori, Italian Cypress, Strawberry, Fig, Ichiyakuso, Ginkgo, Itlan, Carob, Ibukitorano, Imosemiru, Nettle, Iran Iran, Iris Iris Parida, Iwabenkei, Iwamituba, common bean, fennel, witania somunifera, turmeric, usubasaicin, moray moth, udo, sea urchin Ume, Uyaku, Urarkanthus, Uri, Wurbaraktsuka, Ulmus Davidiana, Uncarriagementa, Unshimichikan, Ages, Eilan Thai, Edelweiss, Ezoukogi, Ezo Snake Strawberry, Ezomisohagi, Echinashi, Echinaceaparida, Enishida, Ebine, Ebine , Enju, Pea, Emperor juniper, Enmeiso, Soryo mugwort, Oren, Milk thistle, Giant scorpion, Ozodenda, Giant peony, Okis macata, Okis muscara, Orchid, Orc (European oak), Ogulma, Oval Japanese cypress, Greater Crape myrtle, Greater Orange, Greater Palm, Ominocephalus, Barley, Allspice, Okazeri, Okra, Osiroy Bana, Ginseng, Hypericum, Onigashi, Onisarubia, Onihamadakon, Onis, Opuntia Tuna, Opuntia Streptacantha, Opuntia Tuna, Dutch Mustard, Dutch Peonies, Olives, Origanum Heracreoticum, Orthosiphon Stamineus, Ormenis murkis , Orange, Orobankerapum, Gardenia Tahitensis, Carnation, Khaya Sene Galensis, Cacao, Oyster, Cassia, Cashew Nut, Cascara Sagrada, Cassia Italiana, Kappa Ficus Albarezi, Cattleya, Canadian Hydratis, Canary Tree, Canina Rose , Birch bamboo, turnip, cattail (cocoon), chamomile (chamomile), komi bouuki, cayupte, chrysanthemum man, oats, oats, moss Toki, guarana, garikkabara, cauliflower, karin, caruna (carrot), garcinia cambodia, carrot, crayfish, ginseng, licorice, kantachibi, kistrawberry, kiwi, kikarasuuri, chrysanthemum, kigeria africana, yellowfin aloe Quinoa, yellowfin, yellow-bellied white bean, yellow-spotted peas, millet, gymnema, yellow magnolia, cassava, cabbage, caraway, cucumber (cucumber), yellowfish, gyory, gyoryubai, kiraya, kiri, gimba, watermelon, watermelon Guava, quince seed, queercas alba, kuinoki, wolfberry, celandine, kudu, camphor, damselfly, gardenia, bearberry, kumazasa, ku Tsutsura, Anemonefish, Cumin, Clamelli Atriandra, Clara, Granbury, Chris Mummaritimum, Grindelarobusta, Clintonia Borealis, Burma Sow, Walnut, Grapefruit, Clematis, Black pepper, Blackcurrant, Black-bellied Blackberry, Globe, Blackcurrant , Caquette, Kay (Cinnamon), Geum Urbanum, Geum Rivere, Cape Aloe, Poppy, Geckavidin, Geckoge, Ghetto, Kemiyama Zorina, Gentiana, Gentiana Prostrata, Gennoshoko, Kemponashi, Koki, Kokuchitan, Koukeiten, Kou Iga , Koganebana, Coccinia Indica, Cocktan, Cochlearia officinalis, Cowberry, Coco , Gosho Strawberry, Pepper, Koshiro no Sendangsa, Cochineal Cactus, Kocho Sekkoku, Kochoran, Konara, Kochakobe, Burdock, Sesame, Wheat, Rice, Koranoki, Coriander, Coleus, Coleus Barbatus, Gorenshi, Koroha, Conzurango, Comfrey Tammicransum, Sisal Asa, Saisin, Cyperus Esculentus, Cypress, Cypress, South Rare Involcata, Saximas Button Kale, Sakura, Sakurabukanboku, Pomegranate, Sugar Maple, Sugarcane, Sugar Pine, Sasanca, Sassafrasoki, Saffron, Sabon Soup Salix nigra, crape myrtle, sanguinaria canadensis, hawthorn, sansikisumire, sanchinin carrot, sanshuyu, sansho , Sunpens, Citea medullaris, Cyanotis Arachnoidea, Shea butter, Shiozaki, Shisimbrium Irio, Sistrose (Rabdanum), Sistus smuperiensis, Sisturanifels, Perilla, Sichenge, Linden, Shimbugi, Gypterix Odrata, Siberian fir, Shimalba, Shimifugadafurika, Shimotsukeso, potato, peonies, jasmine, janohige, janomerica, shukusha, juzudama, shukkonikamisou, juniper mexicana, junesai, ginger, shozuk Dioscorea, Birch, Silane, Logaris, White-faced Silica, White-faced Lupine, White-faced Cotton, Shinkonakarisaya, Synthpalm dulcificum, Symbidium , Symprocosacemosa, Sweet Acacia, Watermelon, Honeysuckle, Scabiosa Albensis, Sugina, Scutellaria Galericulata, Stevia, Strobe Pine, Spiny Bamboo, Spirulina Platensis, Spirulina Maxima, Suveruhiyu, Sperm Wheat, Sumilux Alice, Sumilux Alice Trothiaehoria, Acacia, Acacia, Acacia, Nettle, Psyllium psyllium, Hypericum perforatum, Acacia serrata, Acacia serrata, Acacia caladium, Acacia carrot, Acacia vulgara, Acacias edulis, Acacias azalea , Linden tree, white willow, dandelion, boxwood, horse chestnut, seiyo Sea urchins, pears, eustoma, rowan, ceylon nikki, elderflowers, carrots, gerbils, yarrow, hazel, antelope, holly, holly, cherry blossoms, primroses, primroses Strawberry, Ceylon Nikkei, Sage, Cecropia obtusifolia, Sequoia cedar, Cecil Oak, Sedum Purpleum, Zeniaoi, Senega, Geranium, Sercidium Florida, Cereus grandiflorus, Celery, Senkyu, Centifolia rose, Centipeda Cunninghammy, Senninkoku, Sempukuka, Semburi, Sojutsu, Sawakuhi, Saw Palmetto, Sokei, Buckwheat, Soranum Ricokarpum Daiukyo, Daikon, Daisanchiku, Soybean, Taisou, Daidai, Taitsuogi, Thyme, Hinoki, Takasaburo, Tachibakuso, Tachibana, Tabinoki, Tabebia Abernedae, Tamasaki Tsumufuji, Damask Rose, Onion, Damiana, Tara Gong Fira, Chigaya, Tea (tea), Chaboteisou, Tuberose, Clove, Datura, Chung bean, Chileatmentosa, Tsukushimanabeetsubi, Tsukubakusa, Tsurugumi, Tsurugukudami, Tsurureishi, Tea Tree, Dioscorea Composita, Dioscoreavirosa, Dioscorea mexicana, Teuchigurumi, Tecoma clear squirrel, Tetsuzainoki, Duke, DuBoisley Cardiac, Terminaria, Tencha, Germany Spruce, German spruce, Capsicum, Capsicum, Toki, Toki-Senka, Tonin, Capsicum spruce, Spruce, Corn, Corn silk, Capsicum, Tosa, Dokudami, Dokuninjin, Toshi (Plum), Tomato, Tomato, Trigonellafoenum Tormentilla, Toro-Aoimodoki, Nagabagi-shigishi, Nagii-kada, eggplant, natsuna, jujube, feverfew, jujube, jujube, jujube, nanyo-sou, nanbanai, nanbansafuji, nioisumire, niyu-teigai Leek, carrot, garlic, nymphea alba, white deer, white rose, white rose, white violet, wild rose, wild rose, pineapple, high Viscous, Pinus, Baobab, Bacchusia triodora, Bacmondo, Bacopamonniera, Hagoromogusa, Lotus, Parsley, Patchouli, Pepper crab, Baccarius genisteroides, Passiflora arata, pearl barley, banana, Hanahaku, honeysuckle, vanilla, vanilla Cis, Hanesenna, Papaya, Paphiopedilum Maudiae, Haberlea Rhodopensis, Hermanus, Hamamelis, Hayatouri, Rose, Parietalia, Harienju, Harpagophyta, Palmarosa, Baros Mabetzulina, Van Turmeric, Pansy, Bambara Egret, Beet, Holly , Bitter almond, bitter orange, hydrastis canadensis, daisies, daisies, binankazura, pinusheda, hinoki Ki, Hibamata, daisies, Hipofaerarum noides, sunflowers, Himekouji, Himekora, Himetsunichinichiso, Himena Air Kulbaril, Himefuuro, Sandalwood, Chickpea, Hiramame, Himehariso, Bellows, Pirocarpus pirophyrus Paniculata, Fusenkazura, Pueraria Mirifica, Ferula Garvaniflua, Bukit Dandelion, Bukkuri, Fusazaki Sesen, Fusagisuri, Fusagifugi, Fusanus Spicatus, Petit Glen, Petit Petalum Orakoides, Bussouge, Butcher Bloom, Pterocarp Grapes, beetle, beech, scallops, scallops, scallops, fragalia chiroensis, brazil nuts, french caigan Leopard, French lavender, Plantago goat, Plantago gossip, Plantago gossilium, Primula shikimensis, Prunes, Prunus africana, Prunus serotica, Plumeria, Plectrants barbatas, Bretcia hyacinthina, Propolis, Bay, Hayflower, Hazelnut , Pecan, vetiver, loofah, penny royal mint, garlic, safflower, safflower assembly, pepo pumpkin, hera plantain, pelargonium capitatum, helicrism arenarium, helicopter angstiphorium, helichmus italicum, bergamotchi peltholda , Peruvian balsam, Bergamot, Berberis aquiholium, Veronica kaficinaris, henna, henruda, broomfish, boushuboku, boushunka, ho Bosenka, Spinach, Spinach, Hawkweed, Honoki, Hokubei Fusoso, Bocoa Prouasensis, Boswellia Serata, Hosobasenna, Hosobarengiku, Bodaiju, Button, Hop, Poterium Officinale, Jojoba, Polygonum mutiflorum, Bordeaux, Bordeaux, Ponde , Magnolia Officinalis, Magnolia Biondi, Magwa, Magella, Masaki, Madake, Pine, Matsurika, Matecha, Madonna Lily, Majorana, Maria Thistle, Malpigia grabra, Quince, Marronie, Mango, Mangosteen, Manscapella , Manjugiku, Mandarin Orange, Mandrake, Mishima Psycho, Mizuhakka, Mizu Lemon, Mitsuyanagi, Mitsugasiwa, Mitra Carpath Skaber Mimosa Tenui Flora, Myrcia duvia, Myrrh (Motsuyakuju), Myrotamus flaverifolia, Milobaran, Mukuroji, Murasaki, Murasakikibu, Murasakikimburi, Murasakibareniku, Murayako Enji, Mebouki, Mematsuyogusa, Melia Azajirakuta, Melissa Merirot, Melosria, Melon, Mentaalbensis, Moukomomogi, Mourera fulviachiris, Mokuren, Moskatah rose, Mosbean, Motsuyakuju, Peach, Momotamana, Yakumoso, cornflower, Yashabushi, Yachiyanagi, Yanamagyamoya, Yanamagyamo, Yanamagyamoya, Yanamagyamoya, Yanamagyamoya , Eucalyptus, Eupatium Ayapana, Eupatium rebaudian umbertni, Yukinoshita, Yuzu, Yuso , Yucha, Yucca Grauca, Yukka Shijigera, Lily, Crested Beetle, Crested Vulgaris, Crested pokeweed, European Duckweed, European Raspberry, European Glycan, European Porcupine, European white birch, European beech, European mantis, European fir, Artemisia , Artemisia, Lychee, Lima Bean, Lime, Rye, Lilac, Radiata Pine, Latania, Peanut, Ranunculus Ficaria, Labandula Hybrida, Raffma, Lavender, Larix Europaea, La Rare di Balikata, Rare Mexicana, Rambutan, Riso, lysosamnium column, lithoaceta glutinosa, longan, lyrios mabataki, apple, rooibos, lupine bucarnosus , Lubusviros, Lumpuyan, Borage, Rurihienso, Respedeza, Lesedarteola, Lettuce, Redama, Redam pulse train, Lebanese cedar, Levischium officinale, lemon, lemongrass, forsythia, rosewood, rosemary, low bush blueberry, roman camomile , Laurel (Laurel), Logwood, Robusta coffee, Wild thyme, Wasabi, Wasabi radish, Wasabi tree, Cotton grass, Cotton smelt, Walthera indica, Warmoko.

  Also, Asco Film Nodosum, Aname, Oukimo, Okinawa Mozuku, Gigalchinasterata, Kujermaniela Girata, Sargassum Philippendura, Sargassum Fusifom, Sargassum Muticam, Sufasseraria Scoparia, Durubirea Antarctica, Padina Pavonica, Himanteria Elongata, Fucus Serats, Pervetian Canarikurata, Macrocystis pirifera, Mitsushi Kombu, Laminaria chlorosica, Laminaria Croustoni, Laminaria diguita, Laminaria Hiperborea, Wakame, Asparagopsis almata, Igis , Kagiibaranori, Catamen giraffe rhinoceros, Geridium curtyra cineum, Saimi, Striped primrose, Dulse, Chino Limo, Tochaka, Porphyridium cruentum, Malvatishima Nori, lysosamnium coralioides, anaoaosa, chlorella emersoni, chlorella pyrenoidosa, Dunaliella salina, Dunaliera bardawiru, hiraanaonori, spirulina platensis, spirulina maxima, Haslea Osteria, dereseria sanguinea, picarourosta Also included are algae such as Crisis cartele, Haematococcus prubiaris, cyanobacteria, condor crisps, coral spider, sea whip, red algae.

  Further examples include lichens and mycelia such as Evernia furfracea, Tsunotake moss, Usnia barbata, Oshagujitake, Hippopotamus, Shiitake, Ningyotake, Himematsutake, Fuyushinatsutake, Cordillera edulis and Cordyceps.

  Among these, akebi stalk extract, asunalo extract, amamo extract, altea extract, arnica extract, aloe vera extract, izayoi rose extract, imosemiru extract, irisu root extract, fennel extract, ages extract, ougon extract (koganebana root extract), lauren extract , Ginseng extract, hypericum extract, Dutch mustard extract, orange oil, cattail extract, chamomile extract, oat extract, carrot extract, raspberry extract, kiwi extract, kidachi aloe extract, yellowfin bark extract (Obaku extract), quince seed extract, gardenia extract , Clara extract, grapefruit extract, clematis extract, chlorella extract, cape aloe extract, ginger pepper extract, kohone extract, savonsowe , Hawthorn extract, sage extract, perilla extract, linden extract, cypress extract, peony extract, ginger root extract, birch extract, cedar extract, pheasant extract, yarrow extract, sage extract, sage oil, mallow extract, assembly extract, soybean extract, Soybean extract, Taiso extract, tea extract, tuberose extract, Tounin extract, dokudami extract, wild rose extract, buckthorn root extract, peppermint oil, pearl barley extract, hamamelis extract, buffalo extract, hibamata extract, loquat leaf extract, fukidan popo extract, butcher bloom extract, beech extract , Peppermint extract, Majorana extract, Marronnier extract, Mishima psycho root extract, Mukuroji extract, Melissa extract, Merirot extract , Peach leaf extract, cabbage berry extract, eucalyptus extract, eucalyptus oil, saxifrage extract, citrus extract, lily extract, Yokuinin extract (seed extract of pearl barley), mugwort extract, lavender extract, lavender oil, litchi extract, lemon extract, rosemary extract , Rosemary oil, wild thyme extract, bituminous extract, hydrolyzed rice extract, hydrolyzed yeast extract, brown algae extract, red algae extract, brown sugar extract, rice extract hydrolyzate, green algae extract, green tea extract, asunalo extract, altea Extract, Izayoi Rose Extract, Iris Root Extract, Ogon Extract, Panax Ginseng Extract, Orange Oil, Chamomile Extract, Carrot Extract, Kidachia Aloe Extract, Yellowfin Bark Extract, Clara Extract, Chlorella Extract, Peonies Extract, Birch extract, Achillea millefolium extract, Sage oil, Tea extract, Tuberose, Dokudami extract, Novara extract, Hamamelis extract, Loquat leaf extract, Beech extract, Maronnier extract, Melissa extract, Merilot extract, Eucalyptus extract, Eucalyptus oil, Yukinoshita extract, Yuzu extract, Lily extract, Mugwort extract, lavender extract, lavender oil, rosemary extract, brown algae extract, red algae extract, rice extract hydrolyzate, green algae extract, green tea extract are more preferred, asunaro extract, izayoi rose extract, eel extract, ginseng extract, chamomile extract, Yellowfin bark extract, Clara extract, Chlorella extract, Birch extract, Achillea millefolium extract, Tuberose, Hamamelis extract, Loquat leaf extract, Beech extract, Lissa extract, Eucalyptus extract, Eucalyptus oil, Yukinoshita extract, Lily extract, Artemisia extract, Brown algae extract, Green tea extract are more preferable, Asunaro extract, Panax ginseng extract, Chamomile extract, Yellowfin bark extract, Chlorella extract, Birch extract, Tuberose, Hamamelis extract, Eucalyptus Most preferred are extracts, yukinoshita extract, and brown algae extract.

  The blending amount of the plant-derived extract is not particularly limited, but if the plant-derived extract is too small, the antibacterial improvement effect may not be obtained. Further, when the amount of plant-derived extract is increased, the antibacterial property is improved accordingly, but when the plant-derived extract exceeds a certain amount, the antibacterial property may not be further improved. Therefore, 0.1-1000 mass parts is preferable with respect to 100 mass parts of (A) component, as for a plant origin extract, 0.5-200 mass parts is more preferable, and 1-100 mass parts is still more preferable. If the content of the plant-derived extract is less than 0.1 part by mass, the antibacterial improvement effect due to the addition of the plant-derived extract may not be sufficiently obtained, and if it exceeds 1000 parts by mass, the antibacterial property is further improved. May not be possible. Moreover, when using 2 or more types of plant origin extracts, it is preferable that the total compounding quantity becomes said range.

  Zinc compounds include, for example, zinc acetate, zinc laurate, zinc myristate, zinc palmitate, zinc ricinoleate, zinc undecylenate, zinc aspartate, zinc acetylmethionine, zinc gluconate, zinc citrate, polypyrrolidone carboxylic acid Organic acid zinc salts such as zinc and zinc picolinate; Zinc sulfonic acid zinc salts such as zinc p-phenolsulfonate; Zinc phosphate zinc salts such as zinc ascorbyl phosphate, sodium cetyl phosphate and DNA zinc; Zinc complexes such as zinc pyrithione Zinc supported zeolite such as (silver / zinc / ammonium) zeolite and silicic acid (ammonium / silver / zinc / aluminum); aluminum hydroxide such as aluminum oxide / zinc, aluminum oxide / zinc / cerium, aluminum oxide / zinc / iron Baked products such as sulfuric acid , Zinc sulfide, zinc chloride, zinc bromide, zinc nitrate, ammonium zinc chloride, zinc aluminum sulfate, potassium zinc sulfate, zinc iodide, basic zinc carbonate and other inorganic zinc salts; (hydroxide / carbonic acid) (Mg / Al / Zinc), zinc oxide and the like.

  Among these, a compound that easily dissolves in water to become zinc ions is preferable, the solubility in 100 g of water at 20 ° C. is preferably 5 g or more, and the solubility is more preferably 10 g or more. Examples of such zinc compounds include zinc sulfate, zinc chloride, zinc gluconate, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, potassium zinc sulfate, and zinc iodide.

  Although the compounding quantity of a zinc compound is not specifically limited, If there are too few zinc compounds, an antimicrobial improvement effect may not be acquired. Further, when the amount of the zinc compound is increased, the antibacterial property is improved accordingly, but when the zinc compound exceeds a certain amount, the antibacterial property may not be further improved. Therefore, 0.02-10 mass parts is preferable with respect to 100 mass parts of (A) component, as for a zinc compound, 0.05-5 mass parts is more preferable, and 0.1-2 mass parts is still more preferable. If the content of the zinc compound is less than 0.1 parts by mass, the antibacterial effect of adding the zinc compound may not be sufficiently obtained. If the content exceeds 1000 parts by mass, the antibacterial properties can be further improved. It may disappear. Moreover, when using 2 or more types of zinc compounds, it is preferable that the total compounding quantity becomes said range.

  The method of using the antibacterial composition of the present invention is not particularly limited, and may be used in the same manner as known antibacterial agents, disinfectants, disinfectants, and antifungal agents for the purposes of antibacterial, sterilization, disinfection, antifungal and the like. it can. For example, commonly employed methods such as a method of spraying on an object to be subjected to antibacterial treatment, a method of applying, a method of impregnating the object, and a method of immersing the object can be used as they are. In addition, the usage includes medical instruments and medical cleaning agents for disinfecting and cleaning affected areas, household cleaning agents for sterilizing dishes, body cleaning agents, food industry cleaners, and container transfer conveyor lubricants. Antibacterial agent for antibacterial processing of food packaging film, fiber, synthetic resin, wood, daily necessities, cosmetics, softener for clothing, aqueous or non-aqueous paint, non-woven fabric, wet tissue or toilet seat cleaner, fiber When used as an antibacterial agent, all fibers such as cotton, polyester, acrylic and nylon may be treated by a general method such as stirring, dipping or spraying. Moreover, it can also apply | coat or spray on the surface for wood, daily necessities, etc. Furthermore, when using about synthetic resin etc., you may make it adhere to the surface by apply | coating or spraying after shaping | molding, and can also knead | mix at the time of a shaping | molding process etc. in order to maintain an antimicrobial effect. Among these, since the antibacterial composition of the present invention has high safety to the human body, it can be suitably used for those directly touching the human body such as cosmetics and cleaning agents.

  The cosmetic of the present invention is a cosmetic containing the antibacterial agent of the present invention. Such cosmetics include, for example, face-wash cream, face-wash foam, cleansing cream, cleansing milk, cleansing lotion, massage cream, cold cream, moisture cream, shaving cream, sunscreen cream, hair nourishing agent, hair cream, hair liquid, set lotion, Hair bleach, color rinse, permanent wave liquid, hand cream, lipstick, various packs, foundation, lotion, cosmetic liquid, milky lotion, eau de cologne, nail cosmetic shampoo, rinse, etc. 0.001 to 10 mass%, preferably 0.001 to 3 mass%, more preferably about 0.01 to 2 mass%.

  Furthermore, the cleaning agent of the present invention is a cleaning agent containing the antibacterial agent of the present invention and a surfactant. Examples of such cleaners include household cleaners such as kitchen cleaners, toilet cleaners, and bath cleaners; body cleaners such as shampoos, hand soaps, and body soaps, and the antibacterial agent of the present invention. Is about 0.001 to 10% by mass, preferably about 0.001 to 3% by mass, and more preferably about 0.01 to 2% by mass.

  Examples of the surfactant that can be used in the cleaning agent of the present invention include an anionic surfactant, a cationic surfactant, and a nonionic surfactant. Among these, it is particularly preferable to use an anionic surfactant or a nonionic surfactant as the cleaning agent of the present invention.

  Examples of the anionic surfactant include higher fatty acid salts, higher alcohol sulfate esters, sulfurized olefin salts, higher alkyl sulfonates, α-olefin sulfonates, sulfated fatty acid salts, sulfonated fatty acid salts, and phosphate esters. Salt, sulfate ester of fatty acid ester, glyceride sulfate ester salt, sulfonate salt of fatty acid ester, α-sulfo fatty acid methyl ester salt, polyoxyalkylene alkyl ether sulfate ester salt, polyoxyalkylene alkyl phenyl ether sulfate ester salt, polyoxy Alkylene alkyl ether carboxylates, acylated peptides, fatty acid alkanolamides or their adducts of sulfuric acid esters, sulfosuccinic acid esters, alkylbenzene sulfonates, alkyl naphthalenes Sulfonate, alkylbenzimidazolesulfonate, polyoxyalkylenesulfosuccinate, N-acyl-N-methyltaurine salt, N-acylglutamic acid or salt thereof, acyloxyethanesulfonate, alkoxyethanesulfonate, N -Acyl-β-alanine or salts thereof, N-acyl-N-carboxyethyltaurine or salts thereof, N-acyl-N-carboxymethylglycine or salts thereof, acyl lactates, N-acyl sarcosine salts, and alkyl or alkenyl Examples thereof include aminocarboxymethyl sulfate.

  Counter ions of such anionic surfactant salts include alkali metal ions such as lithium, sodium and potassium; alkaline earth metal ions such as calcium and magnesium; ammonium; monoethanolammonium, diethanolammonium and triethanolammonium And organic ammonium such as monoisopropanolammonium, diisopropanolammonium and triisopropanolammonium.

  As the higher fatty acid salt, a salt of a fatty acid having 12 to 18 carbon atoms is preferable, and coconut oil fatty acid salt, dodecanoate, tetradecanoate, hexadecanoate, and oleate are more preferable. Similarly, as the higher alkyl sulfate ester salt, alkyl having 10 to 18 carbon atoms is preferable, and one having 12 to 16 carbon atoms is more preferable. As the polyoxyethylene alkyl ether sulfate ester salt, alkyl having 10 to 18 carbon atoms is preferable, and one having 12 to 16 carbon atoms is more preferable. Moreover, 1-12 are preferable, as for the average degree of polymerization of a polyoxyethylene group, 2-10 are more preferable, and 3-8 are still more preferable.

  Among these anionic surfactants, since they are less irritating to the skin etc., higher fatty acid salts, higher alkyl sulfate esters, α-sulfo fatty acid methyl ester salts, higher alcohol sulfate esters, polyoxyethylene alkyl ethers Sulfuric acid ester salts, polyoxyethylene sulfosuccinic acid alkyl ester salts, and monoalkyl phosphoric acid ester salts are preferable, and higher fatty acid salts, higher alkyl sulfuric acid ester salts, and polyoxyethylene alkyl ether sulfuric acid ester salts are more preferable. For the same reason, sodium ions, potassium ions, ammonium, and triisopropanolammonium are preferable as the counter ion of the salt of the anionic surfactant.

  Examples of the nonionic surfactant that can be suitably used in combination with the antibacterial composition of the present invention include polyoxyalkylene alkyl ether, polyoxyalkylene alkenyl ether, polyoxyethylene polyoxypropylene alkyl ether (ethylene oxide and propylene). The addition form of oxide may be random or block), polyethylene glycol propylene oxide adduct, polypropylene glycol ethylene oxide adduct, glycerin fatty acid ester or its ethylene oxide adduct, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid Esters, alkyl polyglucosides, sucrose fatty acid esters, alkyl (poly) glycerin ethers, polyglycerin fatty acid esters, polyethylene Glycol fatty acid esters, fatty acid methyl ester ethoxylate.

  Among such nonionic surfactants, polyoxyethylene alkyl ether is preferable, and polyoxyethylene (average addition mole number of ethylene oxide is preferably 4 to 18) alkyl (preferably 12 to 16 carbon atoms) ether is more preferable. preferable. In addition, said surfactant can be used also for the cosmetics of this invention.

  In addition to the surfactant component described above, the cosmetics and cleaning agents of the present invention are other components as long as the object of the present invention is not impaired, for example, silicone oil, thickener, oil agent, powder (pigment, dye) Resin), other antibacterial agents, fragrances, moisturizers, physiologically active ingredients, salts, solvents, antioxidants, chelating agents, pearling agents, neutralizing agents, pH adjusters, enzymes, etc. Can do.

  Examples of the thickener include dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer, cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar , Gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabinogalactan, caraya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, β-glucan, gellan gum And dextran.

  Examples of the oil agent include volatile and non-volatile oil agents, solvents, and resins that are usually used in cosmetics. The oil agent may be a liquid, a paste, or a solid at room temperature, but a liquid that is excellent in handling is preferable. Examples of the oil agent include higher alcohols such as cetyl alcohol, stearyl alcohol, isostearyl alcohol, lauryl alcohol, behenyl alcohol, octyldodecanol, and lanolin alcohol, fatty acids such as isostearic acid, undecylenic acid, and oleic acid, myristyl myristate, and lauric acid. Esters such as hexyl, decyl oleate, isopropyl myristate, hexyl decyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, hydrocarbons such as liquid paraffin, petrolatum, squalane , Wax such as beeswax, lanolin, reduced lanolin, carnauba wax, mink oil, cocoa butter, coconut oil, palm kernel oil, camellia oil, egoma oil, castor oil, Leave oil, corn oil, jojoba oil, oils and fats of rapeseed oil, and the like.

  Examples of the powder include pigments such as red No. 201, yellow No. 4, blue No. 1, black No. 401, lake pigments such as yellow No. 4 Al lake, yellow No. 203 Ba lake, nylon powder, silk powder, and silicone powder. , Cellulose powder, silicone elastomer spherical powder, polymers such as polyethylene powder, yellow iron oxide, red iron oxide, chromium oxide, carbon black, colored pigments such as ultramarine and bitumen, white pigments such as zinc oxide and titanium oxide, talc Body pigments such as mica, sericite and kaolin, pearl pigments such as mica and titanium, metal salts such as barium sulfate, calcium carbonate, magnesium carbonate and magnesium silicate, inorganic powders such as silica and alumina, bentonite, smectite and nitriding Boron etc. are mentioned. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, indeterminate, flake-like, spindle-like, etc.).

  These powders are treated with conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, Surface treatment may be performed in advance by acrylic acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, or the like.

  Other antibacterial agents include, for example, paraben antibacterial agents such as methylparaben and ethylparaben; imidazole antibacterial agents such as thiabendazole and 2-benzimidazolylcarbamate methylpreventol; and carbanilides such as trichlorocarbanilide and cloflucarban Antibacterial agents; thiazole antibacterial agents such as benzothiazole; triazine antibacterial agents such as debuconazole and cabinone; biguanide antibacterial agents such as chlorhexidine hydrochloride and polyhexamethylene biguanide, etc. Should be used with caution in consideration of irritation to the human body.

  Examples of humectants include biopolymers such as diethylene glycol monoethyl ether, deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, sodium lactate, Examples include urea, sodium pyrrolidonecarboxylate, betaine, and whey.

  Examples of the solvent include purified water, ethanol, light liquid isoparaffin, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, and next-generation chlorofluorocarbon.

Hereinafter, the present invention will be specifically described by way of examples. In the following examples and the like,% and ppm are based on mass unless otherwise specified. The compounds used in the experiment are listed below.
(A) Component (A-1) 1- (2-hydroxyethoxy) -2-hexanol (R in the general formula (1) is an alkyl group having 3 carbon atoms, m = 0, n = 1)
(A-2) 1- (2-hydroxyethoxy) -2-octanol (R in the general formula (1) is an alkyl group having 5 carbon atoms, m = 0, n = 1)
(A-3) 1- (2-hydroxyethoxy) -2-decanol (R in the general formula (1) is an alkyl group having 7 carbon atoms, m = 0, n = 1)
(A-4) 1- (2-hydroxyethoxyethoxy) -2-octanol (R in the general formula (1) is an alkyl group having 5 carbon atoms, m = 0, n = 2)
(A-5) 1- (2-hydroxyethoxy) -2-octanol (R ¹ in the general formula (1) is an alkyl group having 5 carbon atoms, m = 0, n = 1) and 2- (2-hydroxyethoxy) ) -1-octanol (R- ⁶ in the general formula (1) is an equimolar mixture with an alkyl group having 5 carbon atoms, m = 1, n = 0) (A-6) methylparaben

B component chelating agent:
(B-1) disodium ethylenediaminetetraacetate (B-2) tetrasodium glutamate diacetate low molecular weight polyol:
(B-3) 1,3-butanediol (B-4) glycerin nitrogen-containing surfactant:
(B-5) Palm fatty acid monoethanolamide (B-6) Lauramidopropylamine oxide (3-dodecylamidopropyl-N, N-dimethylamine oxide)
(B-7) POE (3) Laurylamine (B-8) Palm oil fatty acid amide ethyl hydroxyethyl glycine sodium (sodium cocoamphoacetate)
Plant-derived extract:
(B-9) Chamomile extract (B-10) Camelis extract (B-11) Brown algae extract zinc compound:
(B-12) Zinc sulfate (B-13) Zinc paraphenol sulfonate The extract of (B-9) to (B-11) is a liquid, but in the experiment, based on the solid content from which moisture was removed Blended.

Antibacterial test (minimum growth concentration)
An antibacterial test was conducted according to the following procedure. Using the bacterial solution pre-cultured in bouillon medium, the bacterial solution adjusted to the 10 ⁷ level was placed in a 0.27 ml microplate, and the above compound adjusted to various concentrations between 10240 and 0.625 μg / mL was added to 0. 03 mL was added and stirred well. This mixed solution was cultured at 37 ° C. for 24 hours. After completion of the culture, the turbidity of the microplate was measured, and the minimum concentration of the preservative that inhibited the growth of the test bacteria was defined as the minimum growth concentration (MIC). The fungi used are as follows.
Bacteria 1: Bacillus subtilis IFO3134
Bacteria 2: Escherichia coli ATCC 14948
Fungus 3: Staphylococcus aureus IFO13276

  The antibacterial test results when the above compound is used alone according to the above test method are shown in Table 1 below.

  Next, Table 2 shows the antibacterial test results in the case of the combined use of the component (A) and the component (B). In addition, the test mix | blended B component diluted to the same density | concentration with the A component diluted to various density | concentrations in the ratio of the following table 2, and measured MIC. In addition, in following Table 2, B component ratio is B component amount with respect to 100 mass parts of A component, and B-9-B-11 are solid content conversion. Further, the MIC number is expressed by the concentration of the component (A).

  From Tables 1 and 2 above, (A-1) to (A-5) are inferior in antibacterial properties to parabens (A-6) alone, but they have antibacterial properties higher than parabens when used in combination with component B. I understand that. In addition, since the antibacterial property only with B component was weak, it was confirmed that it is a synergistic effect by 2 component mixing | blending.

Usability Test A lotion was prepared with the formulation shown in Table 3 below, and a usability test was conducted. To 20 female monitors, after washing the face, lotion was applied to the face, and the feeling of use was evaluated according to the following criteria.
○: Everyone feels uncomfortable on the coated part and excellent in usability.
Δ: 1 to 3 people feel uncomfortable at the coated part, and the feeling of use is slightly inferior.
X: Four or more people feel a sense of incongruity in the application part, and the usability is inferior.
The type of component (A) used or the type of comparative product and the results obtained using it are shown in Table 4 below.

Claims (11)

As the component (A), the following general formula (1),

Wherein R is an alkyl group having 3 to 7 carbon atoms, m and n are each independently an integer of 0 to 5, and 1 ≦ m + n ≦ 5,
As the component (B), one or more compounds selected from the group consisting of a chelating agent, a low molecular polyol, a nitrogen-containing nonionic surfactant, a nitrogen-containing amphoteric surfactant, a plant-derived extract, and a zinc compound; An antibacterial composition comprising:   The antibacterial composition according to claim 1, wherein, in the general formula (1), R is an alkyl group having 4 to 6 carbon atoms.   The antibacterial composition according to claim 1 or 2, wherein in the general formula (1), n + m = 1 to 3.   The antibacterial composition according to any one of claims 1 to 3, wherein the chelating agent of the component (B) is 0.5 to 500 parts by mass with respect to 100 parts by mass of the component (A).   (A) The antimicrobial composition as described in any one of Claims 1-3 whose low molecular polyol of (B) component is 0.5-500 mass parts with respect to 100 mass parts of (A) component.   The antibacterial composition according to any one of claims 1 to 3, wherein the nitrogen-containing nonionic surfactant of the component (B) is 0.5 to 500 parts by mass with respect to 100 parts by mass of the component (A).   The antibacterial composition according to any one of claims 1 to 3, wherein the nitrogen-containing amphoteric surfactant of the component (B) is 0.5 to 500 parts by mass with respect to 100 parts by mass of the component (A).   The antibacterial composition according to any one of claims 1 to 3, wherein the plant-derived extract of the component (B) is 0.1 to 1000 parts by mass with respect to 100 parts by mass of the component (A).   The antibacterial composition according to any one of claims 1 to 3, wherein the zinc compound of the component (B) is 0.02 to 10 parts by mass with respect to 100 parts by mass of the component (A).   A cosmetic comprising the antibacterial composition according to any one of claims 1 to 9.   A cleaning agent comprising the antibacterial composition according to any one of claims 1 to 9.