JP2006104080A - Composition and health food having prophylactic or therapeutic effect on gout and bloodstream disorder caused by uric acid - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a therapeutic agent for gout, having a high therapeutic effect and scarcely having an adverse effect. <P>SOLUTION: The subject composition contains a pineapple enzyme, a kiwi enzyme, or an enzyme mixture comprising a combination thereof optionally selected from the enzymes. A health food is prepared by using the composition. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a composition having an effect of preventing or treating blood flow disorders caused by gout and uric acid, and a health food containing the composition.

  Gout is a very old disease in the West, and there are reports that it found urate in the joints of mummies excavated from Egypt. BC reports Hippocrates, the father of medicine. Many people in Western history have suffered from gout, such as Macedonian Alexander the Great, Holy Roman Emperor Carlos V, Prussian King Friedrich the Great, France Louis XIV, religious reform Luther, Puritan Revolutionary Cronwell, Artist Michelangelo, Leonardo da Vinci, Poet Dante, Milton, Bungo Gate, Standar and Mopassant, Genius Physicist Newton, Biologist Darwin and , I have no time to enumerate. On the other hand, in Japan, gout was a disease that had not been seen before Meiji. Portuguese missionary Luis Frois, who visited Japan during the Azuchi-Momoyama period, recorded that Japanese had no gout, and at the beginning of the Meiji period, German doctor Bertz recorded "Japan has no gout." Gout suddenly appeared in Japanese history after the Meiji era, and it actually increased after the war, in the 1960s. It is estimated that there are currently hundreds of thousands of gout patients nationwide. As a factor, changes in Japanese dietary habits have been pointed out.

The cause of this disease is that when food containing purines is ingested, it is converted into uric acid by xanthine oxidase in the body, but if it exists in the blood at a concentration above a certain level, uric acid may crystallize and precipitate. is there. When this stays in a joint or the like, it causes an antigen-antibody reaction by a foreign substance, causing inflammation and pain. In addition, the state in which the crystals of uric acid are present in the blood naturally causes a blood flow disorder, which may cause various symptoms other than gout.

Conventionally, colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), and steroidal drugs have been used as treatments for this disease. However, there are problems such as little therapeutic effect and strong side effects, and new therapeutic agents have been demanded.

On the other hand, there is no known method for obtaining an effect of preventing or treating blood flow disorders due to gout and uric acid by using an enzyme mixture of pineapple enzyme, kiwi enzyme, or any combination selected from these, and a report on this There is no.

  The present invention has been made under such circumstances, and an object thereof is to provide a novel preventive or therapeutic agent for blood flow disorders caused by gout and uric acid and a health food.

  In view of such circumstances, the present inventors have developed proteins, lipids, polysaccharides and other crystal growth in the growth and aggregation of uric acid crystals that cause blood flow disturbance due to gout and uric acid, and retention in body tissues, Under the expectation that an aggregation-promoting substance is involved, the uric acid crystals are refined by dissolving them or decreasing the binding force, or they are released from the tissues of the body, and are discharged from the body or As a result of conducting intensive research and thinking that it can be expected to prevent accumulation in a specific tissue site, pineapple enzyme or kiwi enzyme that has not been used for those purposes until now, or any one selected from these It has been found that this effect can be obtained by the combined enzyme mixture, and the present invention has been completed.

  ADVANTAGE OF THE INVENTION According to this invention, the composition and health food which can prevent or treat the blood flow disorder by a novel gout and uric acid can be provided.

  The novel gout and uric acid-induced blood flow disorder preventive or therapeutic composition and an enzyme that can be used to obtain a health food are pineapple enzyme, kiwi enzyme, or any combination selected from these enzymes To which a substance used as a component of a general health food is added.

These enzymes are not only isolated and purified, but can also be used as they are, an extract containing the enzyme, and a plant having enzyme activity. In that case, it is preferable to use a necessary amount that has an enzyme activity corresponding to the amount of the isolated and purified enzyme.

Content of the enzyme and enzyme mixture which are essential components in the composition and health food of the present invention is 0.1% to 100%, and can be arbitrarily adjusted depending on the dosage form and administration state.

The effective amount of the pineapple enzyme or kiwi enzyme of the present invention, or an enzyme mixture of any combination selected from these, is 1 mg per day for adults for the purpose of preventing or treating blood flow disorders due to gout and uric acid. -10 g, taken once to several times a day. However, the daily intake shown here is merely a guideline, and the specific intake should be determined according to the age, weight, sex, symptoms, and other conditions of the intaker.

In addition, it can contain optional components that are usually used for the purpose of enhancing the efficacy in the manufacture of pharmaceuticals and foods, or at the same time for supplementing nutritional components. Examples of such optional components include lactic acid bacteria, oligosaccharides, various vitamins, oxycaine, wild yam, lipoic acid, GMT (fermented extract), pine bark extract, erythritol, amalty, chitosan, DHA (docosahexaenoic acid), EPA ( Eicosapentaenoic acid), sesamin, propolis, royal jelly, glucosamine, chondroitin, fucoidan, maca, cordyceps, ganoderma, ginseng, coragene, chlorella, blueberry, ginkgo biloba, agarisk, ganashi, curcumin, astaxanthin, pueraria, MSM (methyl)・ Sulphonyl methane), Gymnema sylvestre, Coenzyme Q10, other animal and plant bodies and their extract components, etc., which can contain ingredients and extracts usually used in the field of foods and health foods in any proportion. That.

Moreover, the arbitrary component normally used as a formulation material in manufacture of a pharmaceutical or foodstuff can be contained. Preferred examples of such optional components include excipients, binders, flavoring agents, flavoring agents, lubricants, coating agents, thickeners, emulsifiers, dispersants, colorants, fats and oils, and the like. By treating these essential components and optional components according to a conventional method, the novel gout and uric acid blood of the present invention in the form of powders, granules, tablets, hard capsules, soft capsules, aqueous liquids, oily liquids, suppositories, etc. Compositions and health foods that are effective in preventing or treating flow disorders can be produced. Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to such examples.

Raw materials were mixed according to the following formulation to obtain the desired composition.
Pineapple enzyme 500mg
Kiwi enzyme 9mg
509mg total

Raw materials were mixed according to the following formulation to obtain the desired food.
Pineapple enzyme 500mg
Kiwi enzyme 9mg
Pineapple fruit juice powder 150mg
Lactic acid bacteria FK23 9mg
Oligosaccharide 300mg
Vitamin C 35mg
Vitamin B1 12mg
Vitamin B2 1.2mg
Vitamin B6 1.2mg
Vitamin B12 2μg
Niacin 4mg
Pantothenic acid 4mg
70 μg of folic acid
Vitamin P 8mg
Oxycaine 9mg
Wild Yam 30mg
Lipoic acid 3mg
GMT "fermented extract" 30mg
Pine bark extract 3mg
Erythritol 678mg
Amalty 665mg
Pineapple flavor 60mg
Total (about) 2512mg

An intake test was conducted using the composition of Example 2. In other words, 10 panelists with gout symptoms received the composition of Example 2 and placebo three times a day after meals or after meals, and reported the frequency and extent of gout attacks. The results are shown in Table 1.

An intake test was conducted using the food of Example 2. That is, 10 panelists with gout symptoms were asked to take the food and placebo of Example 2 three times a day after meals or at mealtime, and report the frequency and extent of gout attacks. The results are shown in Table 2.

Claims (2)

An orally administered composition comprising an enzyme mixture of pineapple enzyme, kiwi enzyme, or any combination selected from these. A health food comprising the oral administration composition according to claim 1 added with various nutrients generally permitted for use in food.