JP2004275443A - Liquid medicine preparation kit - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liquid medicine preparation kit which does not waste preparations even when the puncturing sequence of a vial is mistaken. <P>SOLUTION: This liquid medicine preparation kit for preparing the liquid medicine using two vials having different shapes is constituted of a slide cylinder having two skirt parts having different shapes and a double-headed needle. A guide means of the double-headed needle and a pawl for locking the vial mouth are disposed in the slide cylinder. The length of at least one of the skirt parts is longer than the length in the axial direction of the double-headed needle. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a drug solution preparation kit. More specifically, the present invention relates to a drug solution preparation kit suitable for preparing a liquid drug by mixing a dry drug in a container with a solution in another container.
[0002]
[Prior art]
In hospitals and other medical institutions, dry preparations such as powdered or lyophilized drugs in drug containers such as vials are dissolved and used for infusion as infusions, or applied to tissues in the case of biological tissue adhesives. And use it. The operation of preparing such a dry preparation into a drug solution is to connect a container containing a drug and a container containing a dissolving solution for dissolving the drug by using a double-ended needle or a connection tool such as a connecting pipe, and dissolving the drug. This is done by transferring the liquid to a container containing the drug.
The principle that the lysate is moved by the double-ended needle is that when the lyophilized formulation and the vial of the lysate are communicated with each other, a pressure difference occurs due to the negative pressure inside the vial of the lyophilized formulation, and the lysate communicates It moves to the vial on the formulation side through the flow path. Many double-ended needles are used by simultaneously piercing the vial of the preparation and the vial of the lysis solution.
[0003]
However, the timing of puncturing was shifted, and if the vial of the lyophilized preparation was punctured first, the negative pressure was lowered, so that the solution could not be completely transferred to the vial of the preparation after communication. In addition, when piercing the vial one by one, if puncturing only the product first due to human error, the negative pressure state on the product side immediately returns to normal pressure. There was a problem that it could not be moved to the bottle at all and the preparation could not be prepared. In general, these types of preparations are expensive, and cause serious damage to medical institutions such as hospitals.
Patent Literature 1 discloses a kit in which a small protrusion is provided on the inner surface of a hub and can always be punctured from the lower preparation. However, a special cap must be attached to the vial, which increases versatility. In addition, if the user forgets to attach the lower vial, the vial must be screwed in from the lower screw fitting portion, and there is a risk of coring.
[0004]
[Patent Document 1] Japanese Patent Application Laid-Open No. 8-173506
[Problems to be solved by the invention]
An object of the present invention is to solve the above-mentioned problems, and an object of the present invention is to provide a double-ended needle in which the preparation is not wasted even if the puncturing order of the vial is incorrect.
[0006]
[Means for Solving the Problems]
That is, the present invention provides a drug solution preparation kit for adjusting a drug solution using two differently shaped vials, a slide tube having two differently shaped skirt portions and a double-ended needle, wherein the slide tube has a double-ended needle. A kit for preparing a drug solution, comprising a guide means and a claw for engaging a mouth of a vial, wherein at least one skirt portion is longer than an axial length of the double-ended needle.
[0007]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, the present invention will be described in detail with reference to the drawings. FIG. 1 shows a drug solution preparation kit according to one embodiment of the present invention. FIG. 2 shows a double-ended needle part (2) arranged in the slide cylinder (1).
[0008]
(Structure of chemical filling tool)
The structure of FIG. 1 will be described. The drug solution preparation kit includes a slide cylinder (1) and a double-ended needle part (2). The slide cylinder (1) is provided with guide means (3) for moving the double-ended needle portion (2) in the axial direction. Further, the slide cylinder (1) is provided with a claw (12) for locking the mouth of the vial at the puncturing position of the vial. The double-ended needle part (2) is arranged in the slide cylinder (1).
[0009]
(Slide tube)
The slide cylinder (1) is provided with two skirt portions (4, 41, 42). It is preferable that the two skirts (4, 41, 42) have a slightly larger shape than the outer shape of the vial to be set, since the position at which the vial is set can be visually confirmed. A guide means (3) on which the double-ended needle (2) slides is attached to the skirt (4) for setting the solution. The guide means (3) may be a slit or a groove provided on the skirt (4). It is preferable that a protrusion for preventing the double-ended needle portion (2) from easily falling off is provided at the end of the slit.
The two skirt portions (41, 42) have different shapes. Since a general vial is cylindrical, it is desirable to provide skirts (41, 42) having two different diameters. The skirt portion (41) to be punctured first has a diameter smaller than that of the skirt portion (42) to be punctured later, thereby preventing the puncturing order from being incorrect.
It is preferable that a part of the skirt portion (4) be tapered to make the size compact and that the skirt portion (4) comes into close contact with the vial so that the claw (12) can be easily attached.
[0010]
A claw (12) is provided to stop the mouth of the vial at the puncturing position of the vial. It is desirable that the claw (12) be attached to the skirt portion (4) because the slide cylinder (1) can be made compact. The claw (12) may be installed from the partition plate (5) of the slide cylinder (1). A partition plate (5) is preferably attached to the slide cylinder (1) because the position of the double-ended needle is firmly fixed. The center of the partition plate (5) is preferably provided with a hole so that the needle portion (6) can pass through.
The length of the skirt portion (4) to be later punctured is desirably longer than the length of the double-ended needle so as not to erroneously puncture the user's hand or finger and to maintain cleanliness. The skirt portion (4) on the side to be punctured first is preferably longer than the axial length of the double-ended needle portion (2).
The slide cylinder (1) is preferably made of a transparent material so that when the rubber stopper of the vial is punctured, an aim is made through the skirt (4) so that the needle point is located at the center of the rubber stopper. The slide cylinder (1) is preferably made of synthetic resin or the like from an injection molding machine or the like at a low cost, and is preferably made of polycarbonate resin, ABS resin, polyvinyl chloride resin, polystyrene resin, polyurethane resin, or the like.
[0011]
(Double-ended needle)
The double-ended needle part (2) is composed of at least two needle parts (6), a flow path (9) communicating between the needle parts (6), and a slide part (7) that slides inside the slide cylinder (1), A port portion (8) to which a suction means such as a ventilation passage (10) communicating between the inside and the outside of the vial, a filter portion provided in the middle of the ventilation passage (10), and a syringe provided at the end of the ventilation passage (10) is detachable. including.
It is preferable that the needle portion (7) has a diameter of 5 mm or less and a length of 50 mm or less since the puncture resistance of the rubber stopper of the vial becomes small.
The needle (6) is provided with a flow path (9) for communicating the upper and lower vials. It is preferable that the diameter is 0.5 to 3 mm because the molding operation can be easily performed.
It is preferable that the slide portion (7) can be moved in the slide cylinder (1) in the axial direction, because the puncture resistance is reduced and the risk that the needle portion (6) is broken is reduced. More preferably, it is preferable to match the shape of at least a part of the inside of the slide cylinder (1). In addition, it is preferable that a surface parallel to the axis is attached to a part of the shape of the slide cylinder (1) so as not to be shifted from the center axis. The slide portion (7) is provided with projections and the like corresponding to the slits and grooves of the skirt (4). When the port portion (8) is additionally provided, it is preferable that the port portion (8) is fitted into the slit so as to substitute for the projection.
It is preferable to attach the port portion (8) to the slide portion (7) because the contents can be filled in a syringe or the like immediately after the preparation operation. When the port (8) is not provided, it is necessary to remove the vial from the drug solution preparation kit and aspirate it again into a syringe or the like using a needle. Foreign matter may be sucked by the occurrence of coring or the like, which is not preferable.
[0012]
In the case of a formulation which is difficult to be dissolved, it is preferable to provide an air passage (10) communicating with the outside. Inevitably bubbled for if the formulation is not easily solved needs shaken well after injection of solution. In the case of a freeze-dried preparation, foams generated by returning the pressure to normal pressure can be eliminated, and the contents can be sucked in a high yield. It is preferable to provide a filter in the ventilation path (10) so that foreign matter outside the vial does not easily enter when returning to normal pressure, and a filter of a sterilization level (about 0.3 μm or less in diameter) is provided. More preferably, When the ventilation path (10) is provided, a cap (11) is provided so that the inside of the vial does not return to normal pressure during the dissolving operation.
[0013]
Next, the present invention will be described based on an actual operation method.
1. Puncture the lysate vial (FIG. 3). The mouth of the vial is fixed to the claws (12) of the slide cylinder (1). If the user tries to puncture the vial containing the freeze-dried preparation by mistake, as shown in FIG. When trying to puncture the vial of the lysis solution from the direction B, the double-ended needle (2) is not fixed in the slide cylinder (1), so the double-ended needle (2) cannot be punctured. Slide. Here, the user notices the mistake and gets a vial of the lysis solution.
2. Puncture the vial containing the lyophilized preparation and shake until dissolved (FIG. 5).
3. The contents liquid is sucked from the port (8) by the suction means.
[0014]
【The invention's effect】
In the drug solution preparation kit according to the present invention, even if the puncturing order of the vial is incorrect, the preparation is not wasted.
[Brief description of the drawings]
FIG. 1 shows a front view and a partially cutaway side view of a drug solution preparation kit according to one embodiment of the present invention.
FIG. 2 shows a front view and a cross-sectional view of a double-ended needle part of the present invention. FIG. 3 shows a state in which a vial of a lysis solution is punctured with a drug solution preparation kit according to one embodiment of the present invention.
FIG. 4 shows a state in which a user erroneously tries to puncture a vial of a lyophilized preparation with the drug solution preparation kit according to one embodiment of the present invention.
FIG. 5 shows a state in which a vial of a lysate and a vial of a freeze-dried preparation are punctured with a drug solution preparation kit according to one embodiment of the present invention.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Slide cylinder 2 Double-ended needle part 3 Guide means 4 Skirt part 41 Skirt part of vial side of lysate 42 Skirt part of vial side of freeze-dried preparation 5 Partition plate 6 Needle part 7 Slide part 8 Port part 9 Flow path 10 Ventilation path 11 Cap 12 Claw

Claims (1)

In a drug solution preparation kit for adjusting a drug solution using vials having two different shapes, a slide tube having a skirt portion having two different shapes and a double-ended needle are provided. A drug solution preparation kit, further comprising a claw for engaging a mouth of a bottle, wherein at least one skirt portion is longer than an axial length of the double-ended needle.

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