JP2002527503A - New compounds, their preparation and use - Google Patents

Abstract

  (57) [Summary] The invention relates to compounds of general formula (Ia). The compounds are useful in treating and / or preventing conditions mediated by nuclear receptors, particularly peroxisome proliferator-activated receptors (PPARs).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001] Field of the Invention: The present invention relates to novel compounds, pharmaceutical compositions containing them, methods for preparing said compounds, and their use as medicaments. More particularly, the compounds of the invention can be used in the treatment of situations mediated by nuclear receptors, in particular peroxisome proliferator-activated receptors (PPARs). The compounds of the present invention lower blood glucose and triglyceride levels and are therefore useful for the treatment of chronic diseases and disorders such as diabetes and obesity.

The invention also relates to the novel compounds described above, their derivatives, their analogs, their tautomers, their stereovariants, their polymorphs, their pharmaceutically acceptable It also relates to methods for preparing salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. The compounds may be insulin resistance (type II diabetes), impaired glucose tolerance, dyslipidemia, disorders associated with Syndrome X, such as hypertension, obesity, insulin resistance, hyperglycemia, atherosclerosis, hyperlipidemia It is useful for treating and / or preventing coronary artery disease and other cardiovascular disorders. The compounds of the present invention are also useful for the treatment of certain renal diseases, such as glomerulonephritis, filar sclerosis, nephrotic syndrome, hypertensive renal sclerosis. The compounds are also useful for improving cognitive function in dementia, treating diabetic complications, psoriasis, polycystic ovary syndrome (PCOS), and preventing and treating bone loss, such as osteoporosis. BACKGROUND OF THE INVENTION Coronary artery disease (CAD) occurs in patients with type II diabetes and metabolic syndrome (ie, patients in the “fatal quartet” category of impaired glucose tolerance, insulin resistance, hyperglycemia and / or obesity). It is a major cause of death.

[0003] Hypolipidemic fibrates and antidiabetic thiazolidinesones (thiaz)
olidinedione) is not as effective or efficacious as a single treatment for dyslipidemia often observed in patients with type II diabetes or metabolic candidate syndrome, but moderately effective triglyceride-lowering Activity is shown separately. Thiazolidinediones also effectively reduce circulating glucose levels in animal models of type II diabetes and humans. However, compounds of the fibrate type have no beneficial effect on glycemia. Studies on the molecular actions of these compounds have shown that thiazolidinediones and fibrates exert their effects by activating distinct transcription factors of the peroxisome proliferator-activated receptor (PPAR) family, It suggests that increased and reduced expression of specific enzymes and apolipoproteins, respectively, would be key players in regulating plasma triglyceride content. On the one hand, fibrates are PPARα activators that act mainly in the liver. On the other hand, thiazolidinediones are PPARs that act primarily on adipose tissue.
High affinity ligand for γ.

Adipose tissue plays a central role in maintaining lipid homeostasis and energy balance in vertebrates. Adipocytes store energy in the form of triglycerides during nutrient influx and release it in the form of free fatty acids at the time of nutrient deficiency. The growth of white adipose tissue is the result of a continuous differentiation process throughout life. Much evidence indicates a central role for PPARγ activation in initiating and regulating the differentiation of this cell. Several highly specialized proteins are involved during adipocyte differentiation
Induced, most of these proteins are involved in fat storage and metabolism. The exact linkage from activation to change of PPARγ in glucose metabolism, most notably the reduction in insulin resistance in mice, has also not been demonstrated. PPARγ
Activation of lipoprotein lipase (LPL), fatty acid transport protein (FATP) and acyl-CoA synthase (ACS) in adipose tissue but not in muscle tissue
A possible chain that triggers is through free fatty acids. This dramatically lowers the concentration of free fatty acids in plasma and, due to substrate competition at the cellular level,
Skeletal muscle and other tissues with high metabolic rates consequently convert from fatty acid oxidation to glucose oxidation and ultimately have reduced insulin resistance.

[0005] PPARα is involved in stimulating β-oxidation of fatty acids. In rodents, PPARα-mediated alterations in the expression of genes involved in fatty acid metabolism are limited to peroxisome proliferation, ie, mainly liver and kidney, and in rodents pleiotropic cells leading to hepatocellular carcinogenesis. Exists based on the phenomenon of response. The phenomenon of peroxisome proliferation is not seen in humans. In addition to its role in peroxisome proliferation in rodents, PPARα has also been implicated in the control of HDL cholesterol in rodents and humans. This effect is based, at least in part, on the PPARα-mediated transcriptional regulation of the major HDL apolipoproteins, apoA-I and apo-II. The low triglyceridemic effects of fibrates and fatty acids are also
It is involved in ARα and can be summarized as follows: (I) enhanced lipolysis and clearance of residual particles due to changes in lipoprotein lipase and apo C-III levels, (II) fatty acid binding proteins and acyl-CoA By the induction of synthase,
Stimulation of cellular fatty acid uptake and their subsequent conversion to acyl-CoA derivatives, (III)
Induction of the fatty acid b-oxidation pathway, (IV) induction of fatty acid and triglyceride synthesis, and ultimately (V) reduced VLDL production. Thus, both the enhanced catabolism of triglyceride-rich particles and the reduced secretion of VLDL particles constitute a mechanism that contributes to the hypolipidemic effect of fibrates.

[0006] A number of compounds have been reported to be useful in treating hyperglycemia, hyperlipidemia and hypercholesterolemia (US Pat. No. 5,306,726, PCT application no.
WO91 / 19702, WO95 / 03038, WO96 / 04260, W094 / 13650, WO94 / 01420, W
O97 / 36579, WO97 / 25042, WO95 / 17394, WO99 / 08501, WO99 / 19313 and W
O99 / 16758). Summary of the Invention : It seems increasingly clear that glucose lowering as a single approach does not overcome many of the complications associated with type II diabetes and metabolic syndrome.
Therefore, novel treatments for type II diabetes and metabolic syndrome should help reduce the apparent hypertriglyceridemia and reduce hyperglycemia associated with those syndromes.

[0007] The clinical activity of fibrate and thiazolidinedione is
Investigations for compounds exhibiting α and PPARγ activity have been reported in type II diabetes and metabolic syndrome (
That is, impaired glucose tolerance, insulin resistance, hypertriglyceridemia and
And / or obesity) should be guided by the discovery of effective glucose and triglyceride-lowering drugs with high potential.

[0008] DETAILED DESCRIPTION OF THE INVENTION: Accordingly, the present invention is represented by the following general formula (Ia):

[0009]

Embedded image

[Wherein, R¹, R^Two, R^ThreeAnd R^FourAre independently hydrogen, halogen, perhalomethy
, Hydroxy, nitro, cyano, formyl, or C_1-12Alkyl, C_4-12Arche
Ninyl, C_2-12Alkenyl, C_2-12Alkynyl, C_1-12Alkoxy, aryl, a
Reeloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl,
Heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyl
Luoxy, hydroxy C_1-12Alkyl, amino, acylamino, C_1-12Alkyria
Mino, arylamino, aralkylamino, aminoC_1-12Alkyl, C_1-12Arco
Xycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C_1-12
Alkoxy C_1-12Alkyl, aryloxy C_1-12Alkyl, aralkoxy C_1-12
Alkyl, C_1-12Alkylthio, Thio C_1-12Alkyl, C_1-12Alkoxycarboni
Ruamino, aryloxycarbonylamino, aralkoxycarbonylamino,
-COR¹¹, Or -SO_TwoR¹²Where R¹¹And R¹²Are independent of each other, hydroxy
, Halogen, perhalomethyl, C_1-6Alkoxy, or one or more C_1-6Alkyl
Selected from amino optionally substituted by perhalomethyl or aryl;
Optionally, one or more halogen, perhalomethyl, hydroxy, nitro, or sia
R; or R¹And R^Two, R^TwoAnd R^ThreeAnd / or R^ThreeAnd R^FourIs one or more C_1-6By alkyl
Ring A represents a 5 to 6 membered ring, optionally substituted with one or more halogen, perhalomethy;
, Hydroxy, nitro, cyano, formyl, or C_1-12Alkyl, C_4-12Arche
Ninyl, C_2-12Alkenyl, C_2-12Alkynyl, C_1-12Alkoxy, aryl, a
Reeloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl,
Heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyl
Luoxy, hydroxy C_1-12Alkyl, amino, acylamino, C_1-12Alkyria
Mino, arylamino, aralkylamino, aminoC_1-12Alkyl, C_1-12Arco
Xycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C_1-12
Alkoxy C_1-12Alkyl, aryloxy C_1-12Alkyl, aralkoxy C_1-12
Alkyl, C_1-12Alkylthio, Thio C_1-12Alkyl, C_1-12Alkoxycarboni
Ruamino, aryloxycarbonylamino, aralkoxycarbonylamino,
-COR¹¹, Or -SO_TwoR¹²Where R¹¹And R¹²Are independent of each other
Droxy, halogen, perhalomethyl, C_1-6Alkoxy or amino and 1
Or multiple C_1-6Optionally substituted by alkyl, perhalomethyl or aryl
Optionally, one or more halogen, perhalomethyl, hydro
X is substituted by xy, nitro or cyano; X is a valence bond,-(CHR⁹)-,-(CHR⁹) -CH_Two-, -CH = CH-, -O-, -O- (CHR⁹)-, -S-
(CHR⁹)-,-(NR⁹) -CH_Two-,-(CHR⁹) -CH = CH-,-(CHR⁹) -CH_Two-CH_Two-,-(C = O)-, -O-CH_Two-
O-,-(NR⁹) -S (O_Two)-,-(NR⁹)-, -CH = (CR⁹)-,-(CO)-(CHR⁹)-, -CH_Two-(SO)-, -S-,
-(SO)-,-(SO_Two)-, -CH_Two-(SO_Two)-, -CH_Two-O-CH_Two-And where R⁹Is hydrogen, halo
Gen, hydroxy, nitro, cyano, formyl, C_1-12Alkyl, C_1-12Alkoki
Si, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl,
Heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkyl
Si, acyl, acyloxy, hydroxyalkyl, amino, acylamino, C_{1-1 Two} Alkylamino, arylamino, aralkylamino, aminoC_1-12Alkyl,
C_1-12Alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbo
Nil, C_1-12Alkoxy C_1-12Alkyl, aryloxy C_1-12Alkyl, aral
Koxy C_1-12Alkyl, C_1-12Alkylthio, Thio C_1-12Alkyl, C_1-12Alkoki
Cicarbonylamino, aryloxycarbonylamino, aralkoxycarboni
Luamino, -COR¹³, Or -SO_TwoR¹⁴And where R¹³And R¹⁴Are independent of each other,
Hydroxy, halogen, C_1-6Alkoxy or amino and one or more C_1-6 Selected from those optionally substituted by alkyl, perhalomethyl or aryl.
Z is -CH_Two=, -O-, -S-,> SO_Two,> NR^FifteenAnd where R^FifteenIs hydrogen, halogen,
Hydroxy, nitro, cyano, formyl, C_1-12Alkyl, C_1-12Alkoxy, a
Reel, aryloxy, aralkyl, aralkoxy, heterocyclyl, hetero
Aryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, a
Sil, acyloxy, hydroxyalkyl, amino, acylamino, C_1-12Al
Killamino, arylamino, aralkylamino, aminoC_1-12Alkyl, C_1-12 Alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl,
C_1-12Alkoxy C_1-12Alkyl, aryloxy C_1-12Alkyl, aralkoxy C _1-12 Alkyl, C_1-12Alkylthio, Thio C_1-12Alkyl, C_1-12Alkoxycal
Bonylamino, aryloxycarbonylamino, aralkoxycarbonylamino
No, -COR¹⁶, Or -SO_TwoR¹⁷And where R¹⁶And R¹⁷Are independent of each other,
Xy, halogen, C_1-6Alkoxy or amino and one or more C_1-6Archi
Q is selected from -O-, -S-,> NR¹⁸And where R¹⁸Is hydrogen or C_1-6Ar is arylene, heteroarylene, or a divalent heterocyclic group;
Multiple C_1-6Represents optionally substituted by alkyl or aryl; R^FiveIs hydrogen, hydroxy, halogen, C_1-12Alkoxy, C_1-12Alkyl, C_{4-1 Two} -Alkenyl, C_2-12Alkenyl, C_2-12Represents alkynyl or aralkyl;
Optionally, one or more halogen, perhalomethyl, hydroxy, nitro or
Substituted by ano; or R^FiveIs R⁶Forms a bond with; R⁶Is hydrogen, hydroxy, halogen, C_1-12Alkoxy, C_1-12Alkyl, C_{4-1 Two} -Alkenyl, C_2-12Alkenyl, C_2-12Alkynyl, acyl or aralkyl
Optionally; one or more halogen, perhalomethyl, hydroxy, nitro
R or substituted by cyano; or R⁶Is R^FiveForms a bond with; R⁷Is hydrogen, C_1-12Alkyl, C_4-12-Alkenyl, C_2-12Alkenyl, C_2-12 Alkynyl, aryl, aralkyl, C_1-12Alkoxy C_1-12Alkyl, C_1-12A
Lucoxycarbonyl, aryloxycarbonyl, C_1-12Alkylaminocarbo
Nil, arylaminocarbonyl, acyl, heterocyclyl, heteroaryl or
Represents a heteroaralkyl group; optionally, one or more halogen, perhalomethy
R, substituted by hydroxy, nitro or cyano; R⁸Is hydrogen, C_1-12Alkyl, C_4-12-Alkenyl, C_2-12Alkenyl, C_2-12 Alkynyl, aryl, aralkyl, heterocyclyl, heteroaryl or hete
Represents a lower aralkyl group; optionally, one or more halogen, perhalomethyl
, Hydroxy, nitro or cyano; Y is oxygen, sulfur or NR^TenWhere R^TenIs hydrogen, C_1-12Alkyl, Ally
, Hydroxy C_1-12Represents an alkyl or aralkyl group, or Y is NR^TenIf it is
, R⁸And R^TenIs one or more C_1-65- or 6-membered optionally substituted by alkyl
And n is an integer ranging from 1 to 4, or a pharmaceutically acceptable compound
On its salt.

In a preferred embodiment, the present invention relates to¹, R^Two, R^ThreeAnd R^FourBut independently of each other,
Hydrogen, halogen, perhalomethyl, hydroxy, cyano, or C_1-7Alkyl, C_{Four -7} Alkenyl, C_2-7Alkenyl, C_2-7Alkynyl, C_1-7Alkoxy, aryl
, Aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl
, Heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl,
Acyloxy, hydroxy C_1-7Alkyl, amino, acylamino, C_1-7Alkyl
Amino, arylamino, aralkylamino, aminoC_1-7Alkyl, C_1-7Arco
Xycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C_1-7A
Lucoxy C_1-7Alkyl, aryloxy C_1-7Alkyl, aralkoxy C_1-7Archi
, C_1-7Alkylthio, Thio C_1-7Alkyl, C_1-7Alkoxycarbonylamino,
Aryloxycarbonylamino, aralkoxycarbonylamino, -COR¹¹, or
Is -SO_TwoR¹²Where R¹¹And R¹²Are independent of each other, hydroxy, perhalo
Methyl, C_1-6Alkoxy, or one or more C_1-6Alkyl, perhalomethyl or
Selected from amino optionally substituted by aryl; optionally, one or more
Substituted by halogen, perhalomethyl, hydroxy, nitro or cyano;
Is R¹And R^Two, R^TwoAnd R^ThreeAnd / or R^ThreeAnd R^FourIs one or more C_1-6By alkyl
Formula I, which can form a ring containing 5-7 carbon atoms, which is optionally substituted
The compound of

In another preferred embodiment, the present invention provides that R ¹ , R ² , R ³ and R ⁴ independently of one another are hydrogen, halogen, perhalomethyl, hydroxy, cyano, or C _1-7 alkyl, C _4-7 alkenyl, C _2-7 alkenyl, C _2-7 alkynyl, C _1-7 alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, Acyl, hydroxy C _1-7 alkyl, amino, acylamino, C _1-7 alkylamino, arylamino, aralkylamino, amino C _1-7 alkyl, C _1-7 alkoxy
C _1-7 alkyl, aryloxy C _1-7 alkyl, aralkoxy C _1-7 alkyl, C _1-7 alkylthio, thio C _1-7 alkyl, C _1-7 alkoxycarbonylamino, aryloxycarbonylamino or aralkoxy It relates to compounds of the formula I, which represent carbonylamino.

In another preferred embodiment, the present invention provides that R ¹ , R ² , R ³ and R ⁴ independently of one another are hydrogen, halogen, perhalomethyl, hydroxy, cyano, or C _1-7 alkyl, C _4-7 alkenyl, C _2-7 alkenyl, C _2-7 alkynyl, C _1-7 alkoxy, aryl, aryloxy, aralkyl, aralkoxy, acyl, hydroxy
C _1-7 alkyl, amino, C _1-7 alkylamino, arylamino, aralkylamino, C _1-7 alkoxy C _1-7 alkyl, aryloxy C _1-7 alkyl, aralkoxy
It relates to compounds of the formula I, which represent C _1-7 alkyl or C _1-7 alkylthio.

In another preferred embodiment, the invention relates to¹, R^Two, R^ThreeAnd R^FourBut each other
Independently, hydrogen, halogen, perhalomethyl, or C_1-7Alkyl, C_4-7Alkene
Nil, C_2-7Alkenyl, C_2-7Alkynyl, aryl, aralkyl, hydroxy C_{1 -7} Alkyl, C_1-7Alkoxy C_1-7Alkyl, aryloxy C_1-7Alkyl, or
Aralkoxy C_1-7It relates to compounds of the formula I, which represent alkyl.

In another preferred embodiment, the invention relates to¹, R^Two, R^ThreeAnd R^FourBut each other
Independently, hydrogen, halogen, or C_1-7It relates to compounds of the formula I, which represent alkyl. In another preferred embodiment, the invention relates to R¹, R^Two, R^ThreeAnd R^FourBut each other
Independently relates to compounds of formula I representing hydrogen, chlorine or methyl. In another preferred embodiment, the present invention provides a method, wherein ring A represents a 5-6 membered ring;
Optionally, one or more halogen, perhalomethyl, hydroxy, cyano, or C _1-7 Alkyl, C_4-7Alkenyl, C_2-7Alkenyl, C_2-7Alkynyl, C_1-7Al
Coxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl
, Heteroaryl, heteroaralkyl, heteroaryloxy, heteroaral
Coxy, acyl, acyloxy, hydroxy C_1-7Alkyl, amino, acylami
No, C_1-7Alkylamino, arylamino, aralkylamino, aminoC_1-7Al
Kill, C_1-7Alkoxy C_1-7Alkyl, aryloxy C_1-7Alkyl, Aralkoki
C_1-7Alkyl, C_1-7Alkylthio, Thio C_1-7Alkyl, C_1-7Alkoxycarbo
Nilamino, aryloxycarbonylamino, aralkoxycarbonylamino
, -COR¹¹, Or -SO_TwoR¹²Where R¹¹And R¹²Are independent of each other,
Hydroxy, perhalomethyl, C_1-6Alkoxy, or one or more C_1-6Alkyl
Selected from amino optionally substituted by perhalomethyl or aryl;
Optionally, one or more halogen, perhalomethyl, hydroxy, or cyano
Or a compound of formula I that is substituted.

In another preferred embodiment, the present invention provides a method wherein the ring A represents a 5-6 membered ring,
Optionally, one or more halogen, perhalomethyl, hydroxy, cyano, or C _1-7 Alkyl, C_4-7Alkenyl, C_2-7Alkenyl, C_2-7Alkynyl, C_1-7Al
Coxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl
, Heteroaryl, heteroaralkyl, heteroaryloxy, heteroaral
Coxy, acyl, hydroxy C_1-7Alkyl, amino, acylamino, C_1-7Archi
Ruamino, arylamino, aralkylamino, aminoC_1-7Alkyl, C_1-7Al
Koxy C_1-7Alkyl, aryloxy C_1-7Alkyl, aralkoxy C_1-7Alkyl
, C_1-7Alkylthio, Thio C_1-7Alkyl, C_1-7Alkoxycarbonylamino, a
Substituted by reeloxycarbonylamino or aralkoxycarbonylamino
To the compounds of formula I

In another preferred embodiment, the present invention provides a method, wherein ring A represents a 5-6 membered ring,
Optionally, one or more halogen, perhalomethyl, hydroxy, cyano, or C _1-7 Alkyl, C_4-7Alkenyl, C_2-7Alkenyl, C_2-7Alkynyl, C_1-7Al
Coxy, aryl, aryloxy, aralkyl, aralkoxy, acyl, hydr
Roxy C_1-7Alkyl, amino, C_1-7Alkylamino, arylamino, aralkyl
Lumino, C_1-7Alkoxy C_1-7Alkyl, aryloxy C_1-7Alkyl, aral
Koxy C_1-7Alkyl or C_1-7For compounds of formula I substituted by alkylthio
I do.

In another preferred embodiment, the present invention provides a method wherein the ring A represents a 5-6 membered ring,
Optionally, one or more halogen, perhalomethyl, or C _1-7 alkyl, C _4-7 alkenynyl, C _2-7 alkenyl, C _2-7 alkynyl, C _1-7 alkoxy, aryl, aralkyl, hydroxy C _{1 -7} alkyl, C _1-7 alkoxy C _1-7 alkyl, aryloxy C _1-7 alkyl, or aralkoxy C _1-7 alkyl.

In another preferred embodiment, the invention relates to compounds of formula I, wherein ring A represents a 5- to 6-membered ring optionally substituted by one or more chlorine or methyl groups. In another preferred embodiment, the invention provides a method, wherein X is a valence bond,-(CHR ⁹ )-,
-(CHR ⁹ ) -CH _2- , -CH = CH-, -O-, -O- (CHR ⁹ )-, -S- (CHR ⁹ )-,-(NR ⁹ ) -CH ₂ -,-( CHR ⁹ )
-CH = CH-,-(CHR ⁹ ) -CH ₂ -CH ₂ -,-(C = O)-, -O-CH ₂ -O-,-(NR ⁹ ) -S (O ₂ )-,- (NR ⁹ )-,-
CH = (CR ⁹ )-,-(CO)-(CHR ⁹ )-, -CH _2- (SO)-, -S-,-(SO)-,-(SO ₂ )-, -CH _2- ( SO ₂ )-, or -CH ₂ -O-CH _2- , wherein R ⁹ is hydrogen, halogen, hydroxy, C _1-7 alkyl, C _1-12 alkoxy, aryl, aryloxy, aralkyl, aralkoxy. , Heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, hydroxyalkyl, amino, acylamino, _C1-7 alkylamino, arylamino, aralkylamino, amino _C1-7 alkyl, _C1-7 alkoxy C _1-12 alkyl, aryloxy C _1-7 alkyl, aralkoxy C _1-7 alkyl, C _1-12 alkylthio, thio C _1-7 alkyl, C _1-7 alkoxycarbonylamino, aryloxycarbonylamino, aralkoxy It relates to a compound of formula I, which is carbonylamino.

[0020] In another preferred embodiment, the present invention provides that X is a valence bond,-(CHR⁹)-,
-(CHR⁹) -CH_Two-, -CH = CH-, -O-, -O- (CHR⁹)-, -S- (CHR⁹)-,-(NR⁹) -CH_Two-,-(CHR⁹)
-CH = CH-,-(CHR⁹) -CH_Two-CH_Two-,-(C = O)-, -O-CH_Two-O-,-(NR⁹) -S (O_Two)-,-(NR⁹)-,-
CH = (CR⁹)-,-(CO)-(CHR⁹)-, -CH_Two-(SO)-, -S-,-(SO)-,-(SO_Two)-, -CH_Two-(SO_Two)-, Or -CH_Two-O-CH_Two-And where R⁹Is hydrogen, halogen, hydroxy, C_1-7Al
Kill, aryl, aralkyl, C_1-7Alkoxy C_1-12Alkyl, aryloxy C _1-7 Alkyl or aralkoxy C_1-7For compounds of formula I that are alkyl.

In another preferred embodiment, the present invention provides a method, wherein X is a valence bond,-(CHR ⁹ )-,
-(CHR ⁹ ) -CH _2- , -CH = CH-, -O-, -O- (CHR ⁹ )-, -S- (CHR ⁹ )-,-(NR ⁹ ) -CH ₂ -,-( CHR ⁹ )
-CH = CH-,-(CHR ⁹ ) -CH ₂ -CH ₂ -,-(C = O)-, -O-CH ₂ -O-,-(NR ⁹ ) -S (O ₂ )-,- (NR ⁹ )-,-
CH = (CR ⁹ )-,-(CO)-(CHR ⁹ )-, -CH _2- (SO)-, -S-,-(SO)-,-(SO ₂ )-, -CH _2- ( SO ₂ ) —, or —CH ₂ —O—CH ₂ —, wherein R ⁹ is hydrogen.

In another preferred embodiment, the present invention provides a method wherein X is a valence bond,-(CHR ⁹ )-,
-(CHR ⁹ ) -CH _2- , -CH = CH-, -O-, -O- (CHR ⁹ )-, -S- (CHR ⁹ )-,-(NR ⁹ ) -CH _2- , -O -CH _2-
O-,-(NR ⁹ )-, -S-,-(SO)-or -CH ₂ -O-CH _2- , wherein R ⁹ is hydrogen
For compounds of I. In another preferred embodiment, the invention provides a method, wherein X is a valence bond,-(CHR ⁹ )-,
-(CHR ⁹ ) -CH _2- , -CH = CH-, -O-, -O- (CHR ⁹ )-, -S- (CHR ⁹ )-,-(NR ⁹ ) -CH _2- , -O -CH _2-
O-,-(NR ⁹ )-, -S- or -CH ₂ -O-CH _2- , wherein R ⁹ is a compound of formula I wherein R ⁹ is hydrogen.

In another preferred embodiment, the invention provides a method, wherein X is a valence bond,-(CHR⁹)-,
-(CHR⁹) -CH_Two-, -CH = CH-, -O-, -O- (CHR⁹)-, -S- (CHR⁹)-, -O-CH_Two-O- or -S-
Yes, where R⁹Refers to compounds of formula I that are hydrogen. In another preferred embodiment, the present invention provides that Z is -CH_Two-, -O-, -S- or> NR ^Fifteen And where R^FifteenIs hydrogen, C_1-12Alkyl, C_1-7Alkoxy, aralkyl,
Aralkoxy, hydroxyalkyl, amino C_1-7Alkyl, C_1-12Alkoxy C_{1- 7} Alkyl, aryloxy C_1-7Alkyl or aralkoxy C_1-7Alkyl
The compounds of formula I

In another preferred embodiment, the present invention provides a method, wherein Z is -CH_Two-, -O-, -S- or> NR ^Fifteen And where R^FifteenRefers to compounds of formula I that are hydrogen. In another preferred embodiment, the present invention provides a compound of formula I wherein Z is -O-.
Related. In another preferred embodiment, the invention provides a method, wherein Q is -O-, -S- or> NR.¹⁸In
Where R¹⁸Refers to compounds of formula I, which are hydrogen or methyl.

In another preferred embodiment, the invention relates to compounds of formula I, wherein Q is —O— or> NR ¹⁸ , wherein R ¹⁸ is methyl. In another preferred embodiment, the invention relates to compounds of formula I, wherein Ar represents arylene optionally substituted with one or more C _1-6 alkyl or aryl.

In another preferred embodiment, the invention relates to compounds of formula I, wherein Ar represents phenyl. In another preferred embodiment, the present invention is, R ⁵ is hydrogen, hydroxy, halogen, C _1-7 alkoxy, C _1-7 alkyl, C _4-7 - alkenynyl, C _2-7 alkenyl, C _{2- 7} represents an alkynyl or aralkyl, or a formula wherein R ⁵ forms a bond with R ⁶
For compounds of I.

In another preferred embodiment, the invention relates to^FiveRepresents hydrogen, or R^FiveIs R ⁶ And a compound of formula I which forms a bond with In another preferred embodiment, the invention relates to R^FiveIs hydrogen, hydroxy, ha
Logen, C_1-7Alkoxy, C_1-7Alkyl, C_4-7-Alkenyl, C_2-7Alkenyl
, C_2-7Represents alkynyl or aralkyl, or R^FiveIs R⁶An expression that forms a bond with
For compounds of I.

In another preferred embodiment, the present invention provides a method for preparing R^FiveRepresents hydrogen, or R^FiveIs R ⁶ And a compound of formula I which forms a bond with In another preferred embodiment, the invention relates to R⁷But hydrogen, C_1-7Alkyl, C _4-7 -Alkenyl, C_2-7Alkenyl, C_2-7Alkynyl, aryl, aralkyl
, C_1-7Alkoxy C_1-7Alkyl, C_1-7Alkoxycarbonyl, aryloxyca
Rubonil, C_1-7Alkylaminocarbonyl, arylaminocarbonyl, acyl
, A compound of formula I representing a heterocyclyl, heteroaryl or heteroaralkyl group
About.

In another preferred embodiment, the invention relates to⁷But hydrogen, C_1-7Alkyl, C _4-7 -Alkenyl, C_2-7Alkenyl or C_2-7For compounds of formula I representing alkynyl
I do. In another preferred embodiment, the invention relates to R⁷But C_1-2Formula I representing alkyl
The compound of

In another preferred embodiment, the invention relates to⁸But hydrogen, C_1-7Alkyl, C _4-7 -Alkenyl, C_2-7Alkenyl, C_2-7Alkynyl, aryl, aralkyl
, Represents a heterocyclyl, heteroaryl or heteroaralkyl group; optionally
Represents one or more halogen, perhalomethyl, hydroxy, nitro or cyano
More substituted compounds of formula I.

[0031] In another preferred embodiment, the present invention provides a method for preparing R⁸But hydrogen, C_1-7Alkyl, C _4-7 -Alkenyl, C_2-7Alkenyl, C_2-7Alkynyl, aryl or aralkyl
And a compound of formula I In another preferred embodiment, the invention relates to R⁸Is hydrogen or C_1-2Alkyl
And a compound of formula I

In another preferred embodiment, the present invention provides a method, wherein Y represents oxygen, sulfur or NR ¹⁰ , wherein R ¹⁰ is hydrogen, C _1-7 alkyl, aryl, hydroxy C _1-7 alkyl or aralkyl. It relates to compounds of the formula I which represent the radicals In another preferred embodiment, the invention relates to compounds of formula I, wherein Y represents oxygen.

In another preferred embodiment, the invention relates to compounds of formula I, wherein n is an integer ranging from 2-3. In another preferred embodiment, the invention relates to compounds of formula I, wherein A is benzo. In another preferred embodiment, the present invention provides a compound of formula I, wherein A is a 5-membered ring comprising S
The compound of

In another preferred embodiment, the invention relates to compounds of formula I, wherein X is — (CHR ⁹ ) —CH ₂ —, wherein R ⁹ is H. In another preferred embodiment, the present invention is, X is, -O- (CHR ⁹⁾ - a, where in R ⁹ is directed to compounds of Formula I wherein H. In another preferred embodiment, the present invention is, X is, -S- (CHR ⁹⁾ - a, where in R ⁹ is directed to compounds of Formula I wherein H.

In another preferred embodiment, the invention relates to compounds of formula I, wherein X is —O—CH ₂ —O—. In another preferred embodiment, the invention relates to compounds of formula I, wherein Q is -O-. In another preferred embodiment, the invention relates to compounds of formula I, wherein Q is -S-.

In another preferred embodiment, the invention relates to compounds of formula I, wherein Q is> NR ¹⁸ , wherein R ¹⁸ is C _1-6 alkyl, preferably methyl. In another preferred embodiment, the invention relates to compounds of formula I, wherein Z is -O-. In another preferred embodiment, the invention relates to compounds of formula I, wherein n is 2.

In another preferred embodiment, the invention relates to compounds of formula I, wherein Q is —O—. In another preferred embodiment, the invention relates to compounds of formula I, wherein Ar is phenylene. In another preferred embodiment, the present invention is, R ⁵ is directed to compounds of formula I wherein H.

In another preferred embodiment, the invention relates to compounds of formula I wherein R ⁶ is H. In another preferred embodiment, the invention relates to compounds of formula I, wherein R ⁷ is ethyl. In another preferred embodiment, the invention relates to compounds of formula I, wherein R ⁸ is H.

A preferred compound of the present invention is: 2-ethoxy-3- (4- [2- [2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -Phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate Ester, 2-ethoxy-3- (4- [2- [2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy- 3- (4- [2- [2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2 -[2-phenylethyl-5H-dibenzo [a,
d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [3-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy- 3- (4- [2- [3-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2 -[3-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [3-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy- 3- (4- [2- [3-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [3-phenylethyl-5H-dibenzo [a,
d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 3- (4- [2- [2,8-dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy]- Ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [2,8-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, (4- [2- [2,8-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [2,8-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, (4- [2- [2,8-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [ 2- [2,7-dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [2,7-diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, (4- [2- [2,7-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2 -[2,7-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [2,7-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, (4- [2- [2,7-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [ 2- [3,7-dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [3,7-diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, (4- [2- [3,7-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2 -[3,7-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [3,7-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, (4- [2- [3,7-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-ethyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [7-propyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-ethoxy-3- (4- [2- [7-phenyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy -3- (4- [2- [7-benzyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [7-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-methyl-2-ethyl-5H-dibenzo [a] , d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-propyl-2-ethyl-5H-dibenzo [a, d]) Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [7-phenyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-ethoxy-3- (4- [2- [7-benzyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy -3- (4- [2- [7-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [7-methyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-ethoxy-3- (4- [2- [7-ethyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy -3- (4- [2- [7-Phenyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate,

2-ethoxy-3- (4- [2- [7-benzyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-methyl-2-phenyl-5H-dibenzo [ a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [7-ethyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-ethoxy-3- (4- [2- [7-propyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate, ethyl 2-ethoxy-3- (4- [2- [7-butyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate ester,

2-ethoxy-3- (4- [2- [7-phenylethyl-2-phenyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-methyl-2-benzyl-5H-dibenzo [ a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-ethyl-2-benzyl-5H-dibenzo [a, d ] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [7-propyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate, ethyl 2-ethoxy-3- (4- [2- [7-butyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionate Ester, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [7-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-ethyl-2-phenylethyl-5H-]
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [7-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-phenylethyl-5H-dibenzo] [A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-ethyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [8-propyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-ethoxy-3- (4- [2- [8-phenyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy -3- (4- [2- [8-benzyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [8-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-methyl-2-ethyl-5H-dibenzo [a] , d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-propyl-2-ethyl-5H-dibenzo [a, d]) Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [8-phenyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-ethoxy-3- (4- [2- [8-benzyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy -3- (4- [2- [8-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [8-methyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-ethoxy-3- (4- [2- [8-ethyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy -3- (4- [2- [8-Phenyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate,

2-ethoxy-3- (4- [2- [8-benzyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-methyl-2-phenyl-5H-dibenzo [ a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [8-ethyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-ethoxy-3- (4- [2- [8-propyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate, ethyl 2-ethoxy-3- (4- [2- [8-butyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionate ester,

2-ethoxy-3- (4- [2- [8-phenylethyl-2-phenyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-methyl-2-benzyl-5H-dibenzo [ a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-ethyl-2-benzyl-5H-dibenzo [a, d ] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [8-propyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate, ethyl 2-ethoxy-3- (4- [2- [8-butyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -phenylate Ester, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [8-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-ethyl-2-phenylethyl-5H-]
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [8-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-phenylethyl-5H-dibenzo] [A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [2-methyl-5H-dibenzo [a, d] cycloheptene- 5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [2- Phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [2-phenylethyl-5H-dibenzo [a,
d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [3-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy]- Ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [3-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [3-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [3- Phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [3-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [3-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 3- (4- [2- [2,8-dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -Phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [2,8-Diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4 -[2- [2,8-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [2, 8-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [2,8-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4 -[2- [2,8-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [2 , 7-Dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [2,7-Diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4 -[2- [2,7-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [2, 7-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [2,7-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4 -[2- [2,7-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [3 , 7-Dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [3,7-Diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4 -[2- [3,7-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [3, 7-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [3,7-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4 -[2- [3,7-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 2-ethoxy-3- (4- [ 2- [7-ethyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [7-propyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [7-phenyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- ( 4- [2- [7-benzyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [7-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [7-methyl-2-ethyl-5H-dibenzo [a, d ] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [7-propyl-2-ethyl-5H-dibenzo [a, d] cycloheptene-5) Yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [7-phenyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [7-benzyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- ( 4- [2- [7-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [7-methyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [7-ethyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- ( 4- [2- [7-phenyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid,

2-ethoxy-3- (4- [2- [7-benzyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [7-methyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [7-ethyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [7-propyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [7-butyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [7-phenylethyl-2-phenyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [7-methyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [7-ethyl-2-benzyl-5H-dibenzo [a, d] cycloheptene-5) -Yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [7-propyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [7-butyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [7-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [7-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [7-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [7-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [7-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-phenylethyl-5H-dibenzo [a , d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-ethyl-2-methyl-5H-dibenzo [a, d] cycloheptene- 5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [8-propyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [8-phenyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- ( 4- [2- [8-benzyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [8-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-methyl-2-ethyl-5H-dibenzo [a, d ] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-propyl-2-ethyl-5H-dibenzo [a, d] cycloheptene-5) Yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [8-phenyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [8-benzyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- ( 4- [2- [8-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [8-methyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [8-ethyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- ( 4- [2- [8-phenyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid,

2-ethoxy-3- (4- [2- [8-benzyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-methyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [8-ethyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [8-propyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [8-butyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [8-phenylethyl-2-phenyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-methyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-ethyl-2-benzyl-5H-dibenzo [a, d] cycloheptene-5) -Yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [8-propyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [8-butyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [8-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [8-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [8-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-phenylethyl-5H-dibenzo [a , d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-methyl-10,11-dihydro-5H-dibenzo [a] , d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (2-propyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5) -Yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (2-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-methyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-). Yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (3-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-propyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-phenyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5) -Yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (3-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid ethyl ester, 3- (4- [2- [2,8-dimethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl- Amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [2,8-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino]- Ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)) -Methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [2,8-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dimethyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [2,7-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino]- Ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -Methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [2,7-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dimethyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [3,7-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino]- Ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -Methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- [3,7-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7 -Ethyl-2-methyl-10
, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- ( 7-propyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-propyl-10,11-dihydro-5H-dibenzo [a] , d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-benzyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-benzyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-phenylethyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a] , d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-methyl-10)
, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- ( 8-propyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-propyl-10,11-dihydro-5H-dibenzo [a] , d] Cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-benzyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-benzyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-phenylethyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a] , d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (2-methyl-10,11-dihydro-5H-dibenzo [a] , d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-propyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]- Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)- Amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)) -Amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (3-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-propyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]- Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)- Amino] -ethoxy] -phenyl) -propionic acid,

2-Ethoxy-3- (4- [2- [methyl- (3-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid, 3- (4- [2- [2,8-dimethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -Ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [2,8-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid, 3- (4- [2- [2,8-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -Phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,8-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino ] -Ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [2,8-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid, 3- (4- [2- [2,8-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,7-dimethyl-10,11- Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [2,7-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid, 3- (4- [2- [2,7-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -Phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,7-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino ] -Ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [2,7-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid, 3- (4- [2- [2,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [3,7-dimethyl-10,11- Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [3,7-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid, 3- (4- [2- [3,7-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -Phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [3,7-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino ] -Ethoxy] -phenyl) -2-ethoxy-propionic acid,

3- (4- [2- [3,7-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-ethoxy-propionic acid, 3- (4- [2- [3,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-ethoxy-propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl) -2-methyl-10
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7 -Phenyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7 -Benzyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7- Propyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7 -Benzyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7 -Phenylethyl-2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7 -Ethyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7 -Phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-propyl-10,11-dihydro-5H-dibenzo [a, d] ] Cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7 -Propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7 -Ethyl-2-benzyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

The 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-benzyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7 -Phenylethyl-2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d]) Cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-phenylethyl-10,11-dihydro- 5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d Cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8 -Phenyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8 -Benzyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8- Propyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8 -Benzyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8 -Phenylethyl-2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8 -Ethyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8 -Phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-propyl-10,11-dihydro-5H-dibenzo [a, d] ] Cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8 -Propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8 -Ethyl-2-benzyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-benzyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8 -Phenylethyl-2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d]) Cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-phenylethyl-10,11-dihydro- 5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d ] Cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy ] -Phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy- 3- (4- [2- [2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2 -[2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy- 3- (4- [2- [2-phenylethyl-5H-dibenzo [a,
d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [3-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy) ] -Ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [3-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy- 3- (4- [2- [3-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2 -[3-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [3-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy- 3- (4- [2- [3-phenylethyl-5H-dibenzo [a,
d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 3- (4- [2- [2,8-dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy]- Ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [2,8-Diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2 -[2,8-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [2,8-Dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [ 2- [2,7-dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [2,7-diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2 -[2,7-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [2,7-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [ 2- [3,7-dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [3,7-Diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2 -[3,7-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [3,7-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-ethyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [7-propyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-methoxy-3- (4- [2- [7-phenyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy -3- (4- [2- [7-benzyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [7-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-methyl-2-ethyl-5H-dibenzo [a] , d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-propyl-2-ethyl-5H-dibenzo [a, d]) Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [7-phenyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-methoxy-3- (4- [2- [7-benzyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy -3- (4- [2- [7-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [7-methyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-methoxy-3- (4- [2- [7-ethyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy -3- (4- [2- [7-Phenyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate,

2-Methoxy-3- (4- [2- [7-benzyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-methyl-2-phenyl-5H-dibenzo [ a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [7-ethyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-propyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate, 2-methoxy-3- (4- [2- [7-butyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate ester,

2-methoxy-3- (4- [2- [7-phenylethyl-2-phenyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-methyl-2-benzyl-5H-dibenzo [a] , d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-ethyl-2-benzyl-5H-dibenzo [a, d]) Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [7-propyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate, 2-methoxy-3- (4- [2- [7-butyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate Ester, 2-methoxy-3- (4- [2- [7-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [7-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [7-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-phenylethyl-2-phenylethyl-5H-dibenzo) [A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-ethyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [8-propyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-methoxy-3- (4- [2- [8-phenyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy -3- (4- [2- [8-benzyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [8-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-methyl-2-ethyl-5H-dibenzo [a] , d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-propyl-2-ethyl-5H-dibenzo [a, d]) Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [8-phenyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-methoxy-3- (4- [2- [8-benzyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy -3- (4- [2- [8-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [8-methyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-methoxy-3- (4- [2- [8-ethyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy -3- (4- [2- [8-Phenyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate,

2-Methoxy-3- (4- [2- [8-benzyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-methyl-2-phenyl-5H-dibenzo [ a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [8-ethyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester 2-methoxy-3- (4- [2- [8-propyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate, 2-methoxy-3- (4- [2- [8-butyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate ester,

2-methoxy-3- (4- [2- [8-phenylethyl-2-phenyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-methyl-2-benzyl-5H-dibenzo [ a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-ethyl-2-benzyl-5H-dibenzo [a, d ] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [8-propyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate, 2-methoxy-3- (4- [2- [8-butyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate Ester, 2-methoxy-3- (4- [2- [8-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [8-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [8-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-phenylethyl-2-phenylethyl-5H-dibenzo) [A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [2-methyl-5H-dibenzo [a, d] cycloheptene- 5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2- Phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2-phenylethyl-5H-dibenzo [a,
d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [3-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy]- Ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [3-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [3-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [3- Phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [3-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [3-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 3- (4- [2- [2,8-dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -Phenyl) -2-methoxy-propionic acid,

3- (4- [2- [2,8-Diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4 -[2- [2,8-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4- [2- [2, 8-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [2,8-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4 -[2- [2,8-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4- [2- [2 , 7-Dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [2,7-Diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4 -[2- [2,7-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4- [2- [2, 7-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [2,7-Dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4 -[2- [2,7-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4- [2- [3 , 7-Dimethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [3,7-Diethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4 -[2- [3,7-dipropyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4- [2- [3, 7-diphenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [3,7-dibenzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4 -[2- [3,7-diphenylethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid, 2-methoxy-3- (4- [ 2- [7-ethyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [7-propyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Methoxy-3- (4- [2- [7-phenyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- ( 4- [2- [7-benzyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [7-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [7-methyl-2-ethyl-5H-dibenzo [a, d ] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [7-propyl-2-ethyl-5H-dibenzo [a, d] cycloheptene-5) Yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [7-phenyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Methoxy-3- (4- [2- [7-benzyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- ( 4- [2- [7-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [7-methyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Methoxy-3- (4- [2- [7-ethyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- ( 4- [2- [7-phenyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid,

2-Methoxy-3- (4- [2- [7-benzyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [7-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [7-methyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [7-ethyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Ethoxy-3- (4- [2- [7-propyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [7-butyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [7-phenylethyl-2-phenyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [7-methyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [7-ethyl-2-benzyl-5H-dibenzo [a, d] cycloheptene-5) -Yloxy] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [7-propyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [7-butyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Methoxy-3- (4- [2- [7-phenylethyl-2-benzyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [7-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [7-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [7-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [7-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [7-phenylethyl-2-phenylethyl-5H-dibenzo [a] , d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [8-ethyl-2-methyl-5H-dibenzo [a, d] cycloheptene- 5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [8-propyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Methoxy-3- (4- [2- [8-phenyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- ( 4- [2- [8-benzyl-2-methyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [8-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [8-methyl-2-ethyl-5H-dibenzo [a, d ] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [8-propyl-2-ethyl-5H-dibenzo [a, d] cycloheptene-5) Yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [8-phenyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Methoxy-3- (4- [2- [8-benzyl-2-ethyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- ( 4- [2- [8-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [8-methyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Methoxy-3- (4- [2- [8-ethyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- ( 4- [2- [8-phenyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid,

2-Methoxy-3- (4- [2- [8-benzyl-2-propyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [8-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [8-methyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [8-ethyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Methoxy-3- (4- [2- [8-propyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [8-butyl-2-phenyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [8-phenylethyl-2-phenyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [8-methyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [8-ethyl-2-benzyl-5H-dibenzo [a, d] cycloheptene-5) -Yloxy] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [8-propyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [8-butyl-2-benzyl-5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2- Methoxy-3- (4- [2- [8-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [8-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [8-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [8-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [8-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [8-phenylethyl-2-phenylethyl-5H-dibenzo [a] , d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-methyl-10,11-dihydro-5H-dibenzo [a] , d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (2-propyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5) -Yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (2-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-methyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-) Yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [methyl- (3-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-propyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-phenyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5) -Yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (3-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid ethyl ester, 3- (4- [2- [2,8-dimethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl- Amino] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [2,8-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino]- Ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)) -Methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [2,8-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl-phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dimethyl- 10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [2,7-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino]- Ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -Methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [2,7-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dimethyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [3,7-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino]- Ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -Methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester,

3- (4- [2- [3,7-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7 -Ethyl-2-methyl-10
, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (7-propyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- ( 7-propyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (7-methyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-propyl-10,11-dihydro-5H-dibenzo [a] , d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-benzyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (7-propyl-2-benzyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [methyl- (7-methyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-phenylethyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [methyl- (7-butyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a] , d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-methyl-10)
, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (8-propyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- ( 8-propyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (8-methyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

The 2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-propyl-10,11-dihydro-5H-dibenzo [a] , d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-benzyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

The 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-benzyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [methyl- (8-methyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-phenylethyl-10, 11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-Methoxy-3- (4- [2- [methyl- (8-butyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a] , d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (2-methyl-10,11-dihydro-5H-dibenzo [a] , d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-propyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]- Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)- Amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)) -Amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (3-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-propyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]- Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)- Amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (3-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy]- Phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid, 3- (4- [2- [2,8-dimethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -Ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [2,8-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid, 3- (4- [2- [2,8-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -Phenyl) -2-methoxy-propionic acid, 3- (4- [2- [2,8-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino ] -Ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [2,8-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid, 3- (4- [2- [2,8-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4- [2- [2,7-dimethyl-10,11- Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [2,7-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid, 3- (4- [2- [2,7-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -Phenyl) -2-methoxy-propionic acid, 3- (4- [2- [2,7-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino ] -Ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [2,7-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid, 3- (4- [2- [2,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid, 3- (4- [2- [3,7-dimethyl-10,11- Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [3,7-Diethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid, 3- (4- [2- [3,7-dipropyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -Phenyl) -2-methoxy-propionic acid, 3- (4- [2- [3,7-diphenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino ] -Ethoxy] -phenyl) -2-methoxy-propionic acid,

3- (4- [2- [3,7-Dibenzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl)- 2-methoxy-propionic acid, 3- (4- [2- [3,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -phenyl) -2-methoxy-propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-ethyl) -2-methyl-10
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

The 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7 -Phenyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7 -Benzyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7- Propyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7 -Benzyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7 -Phenylethyl-2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (7-methyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7 -Ethyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7 -Phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-propyl-10,11-dihydro-5H-dibenzo [a, d ] Cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7 -Propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester,

2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7 -Ethyl-2-benzyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (7-propyl-2-benzyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7 -Phenylethyl-2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (7-methyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d]) Cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-phenylethyl-10,11-dihydro- 5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (7-butyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] Cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (8-propyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8 -Phenyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8 -Benzyl-2-methyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8- Propyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8 -Benzyl-2-ethyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8 -Phenylethyl-2-ethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (8-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8 -Ethyl-2-propyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8 -Phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-propyl-10,11-dihydro-5H-dibenzo [a, d ] Cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8 -Propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-phenyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8 -Ethyl-2-benzyl-1
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-methoxy-3- (4- [2- [methyl- (8-propyl-2-benzyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8 -Phenylethyl-2-benzyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (8-methyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d]) Cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-phenylethyl-10,11-dihydro-) 5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy] -phenyl) -propionic acid,

2-Methoxy-3- (4- [2- [methyl- (8-butyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino ] -Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-phenylethyl-10,11-dihydro-5H-dibenzo [a, d Cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 3- (4- [2- [5H-dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy -Ethyl propionate,

3- (4- [2- (6,11-dihydrobenzo [b, e] thiepin-11-yloxy) -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- (6,11-dihydrobenzo [b, e] thiepin-11-yloxy) -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4- [2- (6,11-dihydrobenzo) [B, e] oxypin-11-yloxy) -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester,

3- (4- [2- (2,10-Dichloro-12H-5,7-dioxa-dibenzo [a, d] cycloocten-12-yloxy) -ethoxy] -phenyl) -2
-Ethoxy-propionic acid ethyl ester, 3- (4- [2- (2,10-dichloro-12H-5,7-dioxa-dibenzo [a, d] cycloocten-12-yloxy) -ethoxy] -phenyl) -2
-Ethoxy-propionic acid, 2-ethoxy-3- (4- [2- (2-methyl-9,10-dihydro-4H-1)
-Oxa-3-aza-benzo [f] azulen-4-yloxy) -ethoxy]-
Phenyl) -propionic acid ethyl ester,

3- (4- [2- (10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yloxy) -ethoxy] -phenyl) -2-ethoxy-propanoic acid ethyl ester, 3- (4- [2- (10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yloxy) -ethoxy] -phenyl) -2-ethoxy-propanoic acid, 3- (4- [2- ( [10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl] -methyl-amino) -ethoxy] -phenyl) -2-ethoxy-propanoic acid ethyl ester,

3- (4- [2-([10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl] -methyl-amino) -ethoxy] -phenyl) -2-ethoxy-propane Acid, 3- {4- [2- (6,11-dihydro-dibenzo [b, e] oxepin-11
-Ylsulfanyl) -ethoxy] -phenyl} -2-ethoxy-propionic acid, 2-ethoxy-3- {4- [2- (5-methyl-6-oxo-6,11-dihydro-5H-dibenzo [b] , e] azepin-11-yloxy) -ethoxy] -phenyl} -propionic acid,

3- {4- [2- (4,9-dihydro-1,10-dithia-benzo [f] azulen-4-yloxy) -ethoxy] -phenyl} -2-ethoxy-propionic acid, 3- {4- [2- (12H-5,7-dioxa-dibenzo [a, d] cycloocten-12-yloxy) -ethoxy] -phenyl} -2-ethoxy-propionic acid, or a pharmaceutically acceptable salt thereof salt.

Further preferred compounds of the invention are: 3- {4- [2- (10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yloxy) -ethoxy] -phenyl ｝ -2-ethoxypropionic acid, 3- ｛4- [2- (6,11-dihydro-dibenzo [b, e] oxepin-11
-Ylsulfanyl) -ethoxy] -phenyl} -2-ethoxy-propionic acid, 3- (4- {2-[(10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl -Amino] -ethoxy} -phenyl) -2-ethoxy-propionic acid, 2-ethoxy-3- {4- [2- (5-methyl-6-oxo-6,11-dihydro-5H-dibenzo [b, e] azepine-11-yloxy) -ethoxy] -phenyl} -propionic acid, 3- {4- [2- (4,9-dihydro-1,10-dithia-benzo [f] azulen-4-yloxy)- Ethoxy] -phenyl {-2-ethoxy-propionic acid, 3- {4- [2- (12H-5,7-dioxa-dibenzo [a, d] cycloocten-12-yloxy) -ethoxy] -phenyl}- 2- Butoxy - propionic acid or a pharmaceutically acceptable salt thereof.

In the above structural formulas and throughout the present specification, the following terms have the indicated meanings: The term “C _1-12 alkyl”, as used herein alone or in combination, Means those alkyl groups of the intended length in either a branched, branched or cyclic configuration, ie, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl and the like. Typical C _1-6 alkyl groups are methyl, ethyl, n-propyl, isopropyl, butyl, iso-butyl, sec-butyl, tert-butyl, pentyl, iso-pentyl,
Hexyl, iso-hexyl, cyclopropyl, cyclobutyl, cyclopentyl,
Includes, but is not limited to, cyclohexyl, cycloheptyl, cyclooctyl and the like.

The term “C _{2-n ′} alkenyl” (where n ′ can be from 3 to 15), as used herein, refers to a group of 2 to a specified number of carbon atoms and at least one carbon atom. Represents an olefinically unsaturated branched or straight-chain group having a heavy bond. Examples of such groups are vinyl, 1-propenyl, 2-propenyl, allyl, iso-propenyl,
Includes, but is not limited to 1,3-butadienyl, 1-butenyl, hexenyl, pentenyl and the like.

The term “C _{2-n ′} alkynyl” (where n ′ can be 3 to 15), as used herein, refers to a number of carbon atoms and at least one triple. Represents an unsaturated branched or linear group having a bond. Examples of such groups include, but are not limited to, propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 1-pentynyl, 2-pentynyl and the like.

The term “C _{4-n ′} alkenyl” (where n ′ can be from 5 to 15), as used herein, refers to a group of 4 to a specified number of carbon atoms and at least one carbon atom. Represents an unsaturated branched or straight-chain hydrocarbon group having a heavy bond and at least one triple bond. Examples of such groups are 1-penten-4-yne, 3-pentene-1
-In, 1,3-hexadiene-5-in and the like, but is not limited thereto.

The term “C_1-12"Alkoxy" is used herein alone or in combination.
Through the ether oxygen with its free valence bond from the ether oxygen
Their C of a planned length in a linear, branched or annular shape joined together_{1-1 Two} It means an alkyl group. Examples of linear alkoxy groups are methoxy, ethoxy,
Poxy, butoxy, pentoxy and hexoxy. Examples of branched alkoxy
Are isopropoxy, sec-butoxy, tert-butoxy, isopentoxy and
Sohexoxy. Examples of cyclic alkoxy include cyclopropyloxy, cyclobutyl
Tyloxy, cyclopentyloxy and cyclohexyloxy.

The term “C _1-6 alkoxycarbonyloxy” means a C _1-6 alkoxy group as defined above attached to a carbonyloxy moiety, such as methoxycarbonyloxy, and the like. As used herein, the term " _C4-12- (cycloalkylalkyl)" refers to a branched or straight-chain alkyl group substituted by a carbon atom with a cycloalkyl group. Examples of such groups Includes, but is not limited to, cyclopropylethyl, cyclobutylmethyl, 2- (cyclohexyl) ethyl, cyclohexylmethyl, 3- (cyclopentyl) -1-propyl and the like.

The term “C _1-12 alkylthio,” as used herein, alone or in combination, refers to a carbon atom bonded through a divalent sulfur atom having its free valence bond from a sulfur atom. Reference is made to linear, branched or cyclic monovalent substituents comprising a _1-12 alkyl group and having 1 to 12 carbon atoms, such as methylthio, ethylthio, propylthio, butylthio, pentylthio. Examples of cyclic alkylthio are
Cyclopropylthio, cyclobutylthio, cyclopentylthio and cyclohexylthio.

The term “C _1-12 alkylamino” as used herein, alone or in combination, refers to a C _1-12 alkyl attached through an amino having a free valence bond from a nitrogen atom. Reference is made to linear, branched or cyclic monovalent substituents comprising groups, such as methylamino, ethylamino, propylamino, butylamino, pentylamino. Examples of cyclic alkylamino are cyclopropylamino, cyclobutylamino, cyclopentylamino and cyclohexylamino.

The term “hydroxy C _1-12 alkyl”, as used herein, alone or in combination, refers to a C _1- C as defined herein having an attached hydroxy group. Reference is made to ₁₂ alkyl, such as hydroxyethyl, 1-hydroxypropyl, 2-hydroxypropyl, and the like. The term "arylamino," as used herein, alone or in combination, refers to an aryl, as defined herein, attached through an amino having a free valence bond from the nitrogen atom. For example, phenylamino, naphthylamino, and the like are mentioned.

The term “aralkylamino,” as used herein, alone or in combination, is linked through an amino having a free valence bond from the nitrogen atom.
Aralkyl as defined herein, such as benzylamino, phenethylamino, 3-phenylpropylamino, 1-naphthylmethylamino, 2- (
Reference is made to 1-naphthyl) ethylamino and the like.

The term “amino C _1-12 alkyl,” as used herein, alone or in combination, refers to a C ₁ as defined herein having an attached amino group. _-12alkyl refers to, for example, aminoethyl, 1-aminopropyl, 2-aminopropyl, etc. The term "aryloxycarbonyl", as used herein, alone or in combination, refers to a carbon atom. Refers to an aryloxy as defined herein, attached through a carbonyl having a free valence bond from, for example, phenoxycarbonyl, 1-naphthyloxycarbonyl, or 2-naphthyloxycarbonyl, and the like.

The term “aralkoxycarbonyl,” as used herein, alone or in combination, is defined herein as attached through a carbonyl having a free valence bond from a carbon atom. Such as aralkoxy, such as benzyloxycarbonyl, phenethoxycarbonyl, 3-phenylpropoxycarbonyl, 1-naphthylmethoxycarbonyl, 2- (1-naphthyl) ethoxycarbonyl, and the like.

The term “C _1-12 alkoxyC _1-12 alkyl” as used herein, alone or in combination, as defined herein, has a C _1-12 alkoxy attached thereto. C _1-12 alkyl, such as methoxymethyl, ethoxymethyl,
Mention methoxyethyl, ethoxyethyl, and the like. The term “aryloxy C _1-12 alkyl,” as used herein, alone or in combination, is defined herein as attached by an aryloxy, as defined herein. so that a C _1-12 alkyl, for example phenoxymethyl, phenoxydodecyl, 1-naphthyl oxyethyl refers 2- naphthyl propyl, and the like.

The term “aralkoxy C _1-12 alkyl,” as used herein, alone or in combination, is defined herein as attached by an aralkoxy as defined herein. Reference is made to C _1-12 alkyl, such as benzyloxymethyl, phenethoxydodecyl, 3-phenylpropoxyethyl, 1-naphthylmethoxypropyl, 2- (1-naphthyl) ethoxymethyl and the like.

The term “thio C _1-12 alkyl”, as used herein, alone or in combination, refers to a compound of the formula —SR ′ ″, wherein R ′ ″ is hydrogen, C _1- C ₆ is bonded by a group of alkyl or aryl), C _1-12 alkyl, as defined herein, for example thiomethyl, referred methylthiomethyl, phenylthiomethyl and the like.

The term “C _1-12 alkoxycarbonylamino,” as used herein, alone or in combination, is attached herein through an amino having a free valence bond from a nitrogen atom. _Refers to C _1-12 alkoxycarbonyl as defined in eg, methoxycarbonylamino, carbethoxyamino, propoxycarbonylamino, isopropoxycarbonylamino, n-butoxycarbonylamino, tert-butoxycarbonylamino, and the like.

The term “aryloxycarbonylamino,” as used herein, alone or in combination, is defined herein as attached through an amino having a free valence bond from the nitrogen atom. Reference is made to aryloxycarbonyl such as phenoxycarbonylamino, 1-naphthyloxycarbonylamino or 2-naphthyloxycarbonylamino.

The term “aralkoxycarbonylamino,” as used herein, alone or in combination, is defined herein as attached through an amino having a free valence bond from the nitrogen atom. Aralkoxycarbonyl such as benzyloxycarbonylamino, phenethoxycarbonylamino, 3-phenylpropoxycarbonylamino, 1-naphthylmethoxycarbonylamino, 2
-(1-naphthyl) ethoxycarbonylamino, and the like.

The term “aryl” refers to an aromatic ring such as halogen, amino, hydroxy, C_{1 -6} Alkyl or C_1-6Phenyl, naphthyl, optionally substituted by alkoxy, (
Carboxylic acid aromatic ring selected from the group consisting of 1-naphthyl and 2-naphthyl)
Means The term "arylene" refers to a divalent aromatic ring, such as halogen, amino, hydroxy.
Si, C_1-6Alkyl or C_1-6Phenylene, naph optionally substituted by alkoxy
A carboxylic acid aromatic ring selected from the group consisting of tylene.

The term “halogen” refers to fluorine, chlorine, bromine or iodine. The term "perhalomethyl" means trifluoromethyl, trichloromethyl, tribromomethyl or triiodomethyl. The term “C _1-6 dialkylamino” as used herein refers to two hydrogen atoms independently substituted by a straight or branched saturated hydrocarbon chain having the indicated number of carbon atoms. Amino groups such as dimethylamino, N-ethyl-N-methylamino, diethylamino, dipropylamino, N- (n-butyl)
Reference is made to -N-methylamino, di (n-pentyl) amino and the like.

The term “acyl,” as used herein, refers to a monovalent substituent comprising a C _1-6 alkyl group attached through a carbonyl group, eg, acetyl, propionyl, butyryl, isobutyryl, pivaloyl , Valeryl and the like. The term "acyloxy" as used herein refers to an acyl, as defined herein, attached to an oxygen atom having its free valence bond from an oxygen atom, eg, acetyloxy, propoxy, Reference is made to onyloxy, butyryloxy, isobutyryloxy, pivaloyloxy, valeryloxy and the like.

The term “C _1-12 alkoxycarbonyl,” as used herein, refers to a monovalent substituent comprising a C _1-12 alkoxy group attached through a carbonyl group, eg, methoxycarbonyl, carbethoxy. , Propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, sec-butoxycarbonyl, tert
-Butoxycarbonyl, 3-methylbutoxycarbonyl, n-hexoxycarbonyl and the like.

The term “cyclic ring containing 5 to 7 carbon atoms” as used herein refers to a monocyclic saturated or unsaturated, or aromatic system, such as cyclopentyl, cyclopentenyl, cyclohexyl , Phenyl or cycloheptyl. The term “bicycloalkyl,” as used herein, refers to 6-12
Monovalent substituents comprising bicyclic structures made from carbon atoms, such as 2-norbornyl, 7-norbornyl, 2-bicyclo [2.2.2] octyl and 9-bicyclo [3.3. 1] refers to nonanyl.

The term “heteroaryl,” as used herein, alone or in combination, includes one or more heteroatoms selected from nitrogen, oxygen and sulfur.
Monovalent substituents comprising a 6 to 6 membered monocyclic aromatic system or a 9 to 10 membered bicyclic aromatic system, such as furan, thiophene, pyrrole, imidazole, pyrazole, triazole, pyridine, pyrazine, pyrimidine, Reference is made to pyridazine, isothiazole, oxazole, oxadiazole, thiadiazole, quinoline, isoquinoline, quinazoline, quinoxaline, indole, benzimidazole, benzofuran, pteridine and purines.

The term “heteroarylene,” as used herein, alone or in combination, comprises one or more heteroatoms selected from nitrogen, oxygen and sulfur.
Bivalent substituents comprising a 5-6 membered monocyclic aromatic system or a 9-10 membered bicyclic aromatic system, such as furan, thiophene, pyrrole, imidazole, pyrazole, triazole, pyridine, pyrazine, pyrimidine , Pyridazine, isothiazole, oxazole, oxadiazole, thiadiazole, quinoline, isoquinoline, quinazoline, quinoxaline, indole, benzimidazole, benzofuran, pteridine and purines.

The term “heteroaryloxy,” as used herein, alone or in combination, is defined herein as attached to an oxygen atom that has its free valence bond from an oxygen atom. A heteroaryl, such as a pyrrole, imidazole, pyrazole, triazole, pyridine, pyrazine, pyrimidine, pyridazine, isothiazole, isoxazole, oxazole, attached to oxygen;
Reference is made to oxadiazole, thiadiazole, quinoline, isoquinoline, quinazoline, quinoxaline, indole, benzimidazole, benzofuran, pteridine and purines.

The term “aralkyl,” as used herein, refers to a straight or branched saturated carbon chain containing from 1 to 6 carbon atoms, such as benzyl, substituted by an aromatic hydrocarbon. Phenethyl, 3-phenylpropyl, 1-naphthylmethyl,
Reference is made to 2- (1-naphthyl) ethyl and the like. The term "aryloxy" as used herein refers to phenoxy, 1-naphthyloxy or 2-naphthyloxy.

The term “aralkoxy,” as used herein, refers to a C _1-6 alkoxy group substituted by an aromatic hydrocarbon, such as benzyloxy, phenethoxy, 3-phenylpropoxy, 1-naphthylmethoxy. , 2- (1-naphthyl) ethoxy and the like. The term "heteroaralkyl" as used herein refers to a straight or branched saturated carbon chain containing 1 to 6 carbons, such as (2-furyl) methyl, substituted by a heteroaryl group. 3-furyl) methyl, (2-thienyl) methyl, (3-thienyl) methyl, (2-pyridyl) methyl, 1-methyl-1- (2
-Pyrimidyl) ethyl and the like.

The term “heteroaralkoxy,” as used herein, refers to a heteroaryl as defined herein, attached to an oxygen atom having its free valence bond from an oxygen atom. Aralkyl, eg, bound to oxygen, (2-furyl)
Methyl, (3-furyl) methyl, (2-thienyl) methyl, (3-thienyl) methyl, (2-pyridyl) methyl, 1-methyl-1- (2-pyrimidyl) ethyl.

The term “C _1-6 alkylsulfonyl” as used herein refers to a monovalent substituent comprising a C _1-6 alkyl group attached through a sulfonyl group, for example, methylsulfonyl, ethyl Sulfonyl, n-propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, sec-butylsulfonyl, isobutylsulfonyl, ter-butylsulfonyl, n-pentylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, n-hexylsulfonyl, Reference is made to 4-methylpentylsulfonyl, neopentylsulfonyl, n-hexylsulfonyl and 2,2-dimethylpropylsulfonyl.

The term “C _1-6 monoalkylaminosulfonyl” as used herein refers to a monovalent substituent comprising a C _1-6 monoalkyl group attached through a sulfonyl group, eg, methyl Aminosulfonyl, ethylaminosulfonyl, n-propylaminosulfonyl, isopropylaminosulfonyl, n-butylaminosulfonyl, sec-butylaminosulfonyl, isobutylaminosulfonyl, ter-butylaminosulfonyl, n-pentylaminosulfonyl, 2-methylbutylsulfonyl , 3-methylbutylaminosulfonyl, n-hexylaminosulfonyl, 4
-Methylpentylaminosulfonyl, neopentylaminosulfonyl, n-hexylaminosulfonyl and 2,2-dimethylpropylaminosulfonyl.

The term “C _1-6 dialkylaminosulfonyl” as used herein refers to a monovalent substituent comprising a C _1-6 dialkylamino group attached through a sulfonyl group, eg, dimethylamino Sulfonyl, N-ethyl-N-methylaminosulfonyl, diethylaminosulfonyl, dipropylaminosulfonyl, N- (n-
(Butyl) -N-methylaminosulfonyl, di (n-pentyl) aminosulfonyl and the like.

The term “C _1-6 alkylsulfinyl” refers to a monovalent substituent comprising a linear or branched C _1-6 alkyl group attached through a sulfinyl group (—S (＝ O) —), for example, Mention methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, butylsulfinyl, pentylsulfinyl and the like. The term “acylamino,” as used herein, refers to one of the hydrogen atoms.
Reference is made to amino groups, one of which is substituted by an acyl group, such as acetamido, propionamido, isopropylcarbonylamino and the like.

The term “(C _3-6 cycloalkyl) C _1-6 alkyl” as used herein, alone and in combination, has from 1 to 6 carbon atoms and Linear or branched saturated carbon monosubstituted by _3-6 cycloalkyl, wherein the cycloalkyl group is optionally mono- or polysubstituted by C _1-6 alkyl, halogen, hydroxy or C _1-6 alkoxy; Reference is made to hydrogen chains such as cyclopropylmethyl, (1-methylcyclopropyl) methyl, 1- (cyclopropyl) ethyl, cyclopentylmethyl, cyclohexylmethyl and the like.

The term “arylthio,” as used herein, alone or in combination, refers to an aryl group linked through a divalent sulfur atom having its free valence bond from a sulfur group (such an aryl group). Is optionally mono- or polysubstituted by C _1-6 alkyl, halogen, hydroxy or C _1-6 alkoxy), such as phenylthio, (
Reference is made to (4-methylphenyl) thio, (2-chlorophenyl) thio and the like.

The term “arylsulfinyl” as used herein refers to an aryl group attached through a sulfinyl group (—S (＝ O) —), wherein the aryl group is optionally C _1-6 Alkyl or halogen, hydroxy or C _1-6 alkoxy), for example phenylsulfinyl, (4-chlorophenyl) sulfinyl and the like.

[0322] The term "arylsulfonyl", if the allele used herein, an aryl group (said aryl group attached through a sulfonyl group, optionally, C _1-6 alkyl, halogen, hydroxy or C _{1 -6} mono- or polysubstituted),
For example, mention is made of phenylsulfonyl, tosyl and the like. The term “C _1-6 monoalkylaminocarbonyl” as used herein refers to a monovalent substituent comprising a C _1-6 monoalkylamino group attached through a carbonyl group, eg, methylaminocarbonyl , Ethylaminocarbonyl, n-
Propylaminocarbonyl, isopropylaminocarbonyl, n-butylaminocarbonyl, sec-butylaminocarbonyl, isobutylaminocarbonyl, ter
t-butylaminocarbonyl, n-pentylaminocarbonyl, 2-methylbutylaminocarbonyl, 3-methylbutylaminocarbonyl, 3-methylbutylaminocarbonyl, n-hexylaminocarbonyl, 4-methylpentylaminocarbonyl, neopentylaminocarbonyl , N-hexylaminocarbonyl and 2,2-dimethylpropylaminocarbonyl.

The term “C _1-6 dialkylaminocarbonyl” as used herein refers to a monovalent substituent comprising a C _1-6 dialkylamino group attached through a carbonyl group, eg, dimethylamino Carbonyl, N-ethyl-N-methylaminocarbonyl, diethylaminocarbonyl, dipropylaminocarbonyl, N- (n-
(Butyl) -N-methylaminocarbonyl, di (n-pentyl) aminocarbonyl and the like.

The term “C _1-6 monoalkylaminocarbonylamino” as used herein refers to an amino group in which one of the hydrogen atoms has been replaced by a C _1-6 monoalkylaminocarbonyl group, for example, Methylaminocarbonylamino, ethylamino-
Carbonylamino, n-propylaminocarbonylamino, isopropylaminocarbonylamino, n-butylaminocarbonylamino, sec-butylaminocarbonylamino, isobutylaminocarbonylamino, tert-butylaminocarbonylamino, and 2-methylbutylaminocarbonylamino Mention.

The term “C _1-6 dialkylaminocarbonylamino” as used herein refers to an amino group in which one of the hydrogen atoms has been replaced by a C _1-6 dialkylaminocarbonyl group, eg, dimethylamino Carbonylamino, N-ethyl-N-methylaminocarbonylamino, diethylaminocarbonylamino, dipropylaminocarbonylamino, N- (n-butyl) -N-methylaminocarbonylamino, di (n-pentyl) aminocarbonylamino and the like To mention the ones.

As used herein, the term “heterocyclyl” is monocyclic and is one or more, such as 1-4 carbon atoms and 1-4 N, O or S atoms, Or a monovalent saturated or unsaturated group including a combination thereof. The term "heterocyclyl" refers to a 5-membered heterocyclic compound having one heteroatom (eg, pyrrolidine, pyrroline); a 5-membered heterocyclic compound having two heteroatoms at 1, 2, or 1,3 positions. (E.g., pyrazoline, pyrazolidine, 1,2-oxathiolane, imidazolidine, imidazoline, 4-oxazoline); a 5-membered heterocyclic compound having three heteroatoms (e.g., tetrahydrofuran); having four heteroatoms 5-membered heterocyclic compounds; 6-membered heterocyclic compounds having one heteroatom (eg, piperidine); 6-membered heterocyclic compounds having two heteroatoms (eg, piperazine, morpholine); 6-membered heterocyclic compounds having 3 heteroatoms; and 6-membered heterocyclic compounds having 4 heteroatoms,
However, it is not limited only to them.

As used herein, the term “divalent heterocyclic group” is monocyclic and is one or more, for example, having 1 to 4 carbon atoms and 1 to 4 N , O or S atom, or a divalent saturated or unsaturated group containing a combination thereof. The term “divalent heterocyclic group” refers to a 5-membered ancillary compound having one heteroatom (eg, pyrrolidine, pyrroline); having two heteroatoms in the 1,2 or 1,3 positions 5-membered heterocyclic compounds (eg, prazolin, pyrazolidine, 1,2-oxathiolane, imidazolidine, imidazoline, 4-oxazoline); 5-membered heterocyclic compounds having 3 heteroatoms (eg, tetrahydrofuran); 5-membered heterocyclic compound having 4 heteroatoms; 6-membered heterocyclic compound having 1 heteroatom (eg, piperidine); 6-membered heterocyclic compound having 2 heteroatoms ( For example, piperazine, morpholine); 6-membered heterocyclic compounds having 3 heteroatoms; and 6-membered heterocyclic compounds having 4 heteroatoms. Only in La not limited.

As used herein, the term “5- to 6-membered cyclic ring” refers to one or more carbon atoms and optionally one to four N, O or S atoms or the same. A saturated or unsaturated aromatic, including combinations, is meant. The term "5- to 6-membered cyclic ring" refers to cyclopentyl, cyclohexyl, phenyl, cyclohexenyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, prazolidinyl, pyrazolinyl, piperidyl, piperazinyl, pyrrolyl, 2H-pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl. , Pyrazinyl, pyrimidinyl, pyridazinyl, morpholinyl, thiomorpholinyl, isothiazolyl, isoxazolyl, oxazolyl, oxadiazolyl, thiadiazolyl, 1,3-dioxolanyl, 1,4-dioxolanyl,
5-membered heterocyclic compounds having one heteroatom (eg, thiophene, pyrrole, furan); 5-membered heterocyclic compounds having two heteroatoms at 1, 2, or 1,3 positions ( For example, oxazole, pyrazole, imidazole, thiazole, purine); 5-membered heterocyclic compound having three heteroatoms (eg, thiazole, thiadiazole); 5-membered heterocyclic compound having four heteroatoms Compounds; 6-membered heterocyclic compounds having one heteroatom (eg, pyridine, quinoline, isoquinoline, phenanthridine, cyclohepta [b] pyridine); 6-membered heterocyclic compounds having two heteroatoms Compounds (eg, pyridazine, cinnoline, phthalazine, pyrazine, pyrimidine, quinazoline, morpholine); 6 having three heteroatoms Membered heterocyclic compounds (eg, 1,3,5-triazine)
And 6-membered heterocyclic compounds having 4 heteroatoms, but are not limited thereto.

As used herein, the term “5- or 6-membered nitrogen-containing ring” includes one or more carbon, nitrogen, oxygen or sulfur atoms, or a combination thereof, and 6-membered monocyclic unsaturated or saturated, or monovalent substituents comprising an aromatic system, such as pyrrolidinyl, pyrrolinyl, imidazolidinyl, prazolidinyl, pyrazolinyl, piperidyl, piperazinyl, pyrrolyl, 2H-pyrrolyl, imidazolyl, pyrazolyl, Reference is made to triazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, morpholinyl, thiomorpholinyl, isothiazolyl, isoxazolyl, oxazolyl, oxadiazolyl, thiadiazolyl, 1,3-dioxolanyl, 1,4-dioxolanyl.

Certain terms as defined above may occur more than once in Formula (Ia) above, and based on such occurrence, individual terms will be defined independently of the others . The pharmaceutically acceptable salt-forming moieties of the present invention include salts of the carboxylic acid component, such as Li,
Alkali metal salts such as Na and K salts, alkaline earth metal salts such as Ca and Mg salts,
Includes salts of organic bases such as lysine, arginine, guanidine, diethanolamine, choline and the like, ammonium or substituted ammonium salts, aluminum salts. Salts include, where appropriate, acid addition salts, which include sulfates, nitrates, phosphates, perchlorates, borates, halides, acetates, tartrates, maleates, citrates. , Succinate, palmoate, methanesulfionate,
Benzoate, salicylate, hydroxynaphthoate, benzenesulfonate,
Ascorbate, glycerophosphate, ketoglutarate and the like. Pharmaceutically acceptable solvents can be hydrates or can include other solvents for crystallization, such as alcohols.

Pharmaceutically acceptable salts include compounds of formula (Ia) and 1-4 equivalents of a base, such as sodium hydroxide, sodium methoxide, sodium hydride, potassium t-butoxide, calcium hydroxide, magnesium hydroxide , And the like, a solvent,
For example, it is prepared by reacting with ether, THF, methanol, t-butanol, dioxane, isopropanol, ethanol and the like. Mixtures of solvents can be used. Organic bases such as lysine, arginine, diethanolamine, choline, guandin and their derivatives and the like can also be used. On the other hand, acid addition salts, where applicable, are solvents, such as ethyl acetate, ethers, alcohols,
Acids in acetone, THF, dioxane, etc., such as hydrochloric acid, bromic acid, nitric acid, sulfuric acid, phosphoric acid, p-toluenesulfonic acid, methanesulfonic acid, acetic acid, citric acid, maleic acid, salicylic acid, hydroxynaphthoic acid, ascorbic acid , Palmitic acid,
It is prepared by treatment with succinic acid, benzoic acid, benzenesulfonic acid, tartaric acid and the like. Mixtures of solvents can also be used.

The stereoisomers of the compounds forming part of the invention may be prepared by using the reactants in their single enantiomeric form in the possible manner or in the presence of reagents or catalysts. By reacting in the enantiomeric form of or by resolving a mixture of stereoisomers by conventional methods. Some preferred methods are formed with chiral acids, such as mandelic acid, camphorsulfonic acid, tartaric acid, lactic acid, and the like, or chiral bases, such as brucine, chinoki alkaloids and derivatives thereof, and the like. Includes the use of microbial degradation to degrade diastereomers. Commonly used methods are Jaques et al. “Enan
tiomer, Racemates and Resolution "(Wiley Interscience, 1981). More specifically, compounds of formula (Ia) are prepared by treating chiral amines, amino acids, amino alcohols derived from amino acids with diastereomeric amides 1:
Conventional reaction conditions can be used to convert acids to amides; diastereomers are resolved by fractional crystallization or chromatography, and stereoisomers of compounds of formula (Ia) are pure. Can be prepared by hydrolyzing various diastereomeric amides.

The various polymorphs of the compounds of the general formula (Ia) which form part of the present invention may be prepared under different conditions, for example with different solvents or mixtures thereof which are usually used for recrystallization. Crystallization at different temperatures; can be prepared by crystallization of a compound of formula (Ia) using various cooling modes ranging from very fast to very slow during crystallization. Polymorphs can also be obtained by heating or melting the compound followed by gradual or rapid cooling.
The presence of a polymorph may be determined by solid probe NMR spectroscopy, differential scanning calorimetry, powder X-ray diffraction or other such techniques.

The present invention also relates to a process for preparing the above compounds, wherein said process comprises the steps of: a) formula (Ia) wherein n, Z, Ar, R ¹ -R ⁸ , A, X and Q Is as defined above, with the proviso that R ⁸ is not H] to obtain a compound of formula II

[0335]

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Wherein R ¹ -R ⁴ , A, X and Q are as defined above, and a compound of formula III:

[0337]

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[0338] wherein, L is a leaving group such as halogen, p- triene sulfonate are those methanesulfonate and the like, and n, Z, Ar, are as R ⁵ -R ⁸ are as defined above With the proviso that R ⁸ is not H] b) Formula (Ia) wherein n, Ar, R ¹ -R ⁸ , A, X, Z and Q are as defined above As defined, with the proviso that R ⁸ is not H and Z is not C] to obtain a compound of formula IV

[0339]

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Wherein R ¹ -R ⁴ , A, X, Q and n are as defined above, and a compound of formula V:

[0341]

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Wherein Z, Ar and R ⁵ -R ⁸ are as defined above, with the proviso that R ⁸ is not H, with a suitable coupling agent such as, for example, Dicyclohexylurea, triarylphosphine / dialkylazadicarboxylates, such as PPh ₃ /
C) reacting by using DEAD (diethyl azodicarboxylate) and the like; c) Formula (Ia) wherein n, Ar, R ¹ -R ⁸ , A, X, Z and Q are defined above. Where R ⁸ is not H and Z is not C] to obtain a compound of formula VI

[0343]

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Wherein L is a leaving group such as halogen, p-toluenesulfonate, methanesulfonate and the like, and R ¹ -R ⁴ , A, X, Q and n are as defined above. A compound represented by the following formula V:

[0345]

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Wherein Z, Ar and R ⁵ -R ⁸ are as defined above, with the proviso that R ⁸ is not H. d) reacting with a compound of the formula ( Ia) to obtain a compound of the formula wherein n, Ar, R ¹ -R ⁸ , A, X, Z and Q are as defined above, provided that R ⁸ is not H. In order to obtain a β-hydroxyaldol product which can be dehydroxylated or dehydrated,
I:

[0347]

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Wherein R ¹ -R ⁴ , A, X, Q, Z, Ar and n are as defined above, and a compound of formula VIII:

[0349]

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Wherein R ⁶ -R ⁸ are as defined above, with the proviso that R ⁸ is not H. e) reacting with a compound of formula (Ia) , N, Ar, R ¹ -R ⁴ , R ⁷ -R ⁸ , A, X, Z and Q are as defined above, except that R ⁸ is not H and R ⁵ is with R ⁶ Form a bond]
In order to obtain a compound represented by the following formula VII:

[0351]

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Wherein R ¹ -R ⁴ , A, X, Q, Z, Ar and n are as defined above, and a compound of formula IX:

[0353]

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Wherein R ⁷ and R ⁸ are as defined above, with the proviso that R ⁸ is not H and R ¹¹ is a lower alkyl group. F) Formula (Ia) wherein n, Ar, R ¹ -R ⁴ , R ⁷ -R ⁸ , A, X, Z and Q are as defined above, provided that R ⁸ is H And R ⁵ and R ⁶ are hydrogen] to obtain a compound of the formula X:

[0355]

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Wherein n, Ar, R ¹ -R ⁴ , R ⁷ -R ⁸ , A, X, Z and Q are as defined above, provided that R ⁸ is not H. G) a compound of formula (Ia) wherein n, Ar, R ¹ -R ⁸ , R ⁷ , A, X, Z and Q are as defined above, with the proviso that R ⁸ is not H] to obtain a compound of the formula XI
:

[0357]

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Wherein L is a leaving group, for example halogen, and R ¹ -R ⁸ , A, X, Q, Z and n
Is as defined above, with the proviso that R ⁸ is not H];
Reacting with a compound of the formula XII: HO—R ⁷ XII wherein R ⁷ is as defined above; h) Formula (Ia) wherein n, Ar, R ¹ -R ⁸ , A, X, Z and Q are as defined above, provided that R ⁸ is not H] to obtain a compound of formula XIII:

[0359]

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[Wherein, n, Ar, R¹−R⁶, A, X, Z and Q are as defined above, and R ⁸ Is as defined above, except that R⁸Is not H], and
The following formula: Hal-R⁷ XIV where R⁷Is as defined above, and "Hal" represents Cl, Br or I
I) a compound of the formula (Ia) wherein n, Ar, R¹−R⁸, R⁷, A, X and Q are as defined above
Where R⁸Is not H, and Z is C].
The following formula VI:

[0361]

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Wherein L is a leaving group such as halogen, p-toluenesulfonate, methanesulfonate and the like, and R ¹ -R ⁴ , A, X, Q and n are defined above. And a compound of formula XV:

[0363]

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[Wherein “Met” is trifluoro-methanesulfonate, a halogen compound or C ¹ -C⁶Metal bearing a suitable ligand, preferably selected from alkyl, such as
J) a compound represented by the formula (Ia): wherein n, Ar, R¹−R⁷, A, X, Z and Q are as defined above
And R⁸Is H] to obtain a compound of the formula XVI:

[0365]

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[Wherein, n, Ar, R¹−R⁸, A, C, Z and Q are as defined above, provided that R ⁸ Is not H]. Starting materials are commercially available or readily prepared by methods known to those skilled in the art.
Made.Pharmacological methods: PPARα and PPARr activating activity in vitro.

Principle : The PPAR gene transcription activation assay was based on transient transfection of two plasmids encoding the chimeric test protein and the receptor protein into human HEK293 cells, respectively. The chimeric test protein was a fusion of the DNA binding domain (DBD) from the yeast GAL4 transcription factor to the ligand binding domain (LBD) of the human PPAR protein. The PPAR LBD also contained, in addition to the ligand binding pocket, a native activation domain (activating function 2 = AF2) that allows the fusion protein to function as a PPAR ligand-dependent transcription factor. The GAL4 DBD will bind the fusion protein only to the Gal4 enhancer (not present in HEK293 cells). The reporter plasmid contained the Gal4 enhancer that drives expression of the firefly luciferase protein. After transfection, HEK293 cells expressed the GAL4-DBD-PPAR-LBD fusion protein. The fusion protein, in order,
Binds to the Gal4 enhancer, which controls luciferase expression, and does nothing in the absence of ligand. Upon addition of the PPAR ligand to the cells, the luciferase protein will be produced in an amount corresponding to the activation of the PPAR protein. The amount of luciferase protein is measured by luminescence after addition of the appropriate substrate.

Methods: Cell culture and transfection: HEK293 cells were grown in DMEM + 10% FCS, 1% PS. Cells were seeded in 96-well plates prior to transfection to obtain 80% confluency in transfection. 0.8 μg DNA / well was prepared using FuGene transfection reagent using the manufacturer's instructions (Boehri
nger-Mannheim). Cells were allowed to express protein for 48 hours, followed by addition of compound.

Plasmids: Human PPARα and γ were replaced with cDNAs from liver, intestine and adipose tissue, respectively.
Obtained by PCR amplification using a template. The amplified cDNA was cloned into pCR2.1 and sequenced. LBD from individual isoforms PPAR was generated by PCR (PPARα: aa167-C-terminus; PPARγ: aa165-C-terminus) and plasmid pM1
Fragments were fused to GAL4-DBD by aligning and subcloning the fragments into the vector pM1, which produces αLBD and pM1γLBD. Confirmation of the fusion was confirmed by sequencing. The reporter was constructed by inserting oligonucleotides encoding five repeats of the Gal4 recognition sequence into the pGL2 vector (Promega).

Compounds: All compounds were dissolved in DMSO and diluted 1: 1000 based on addition to cells. Cells were treated with the compound for 24 hours (1: 1000 in 200 μl growth medium with delipidated serum), followed by a luciferase assay. Luciferase assay: Aspirate medium containing test compound and
100 μl of PBS containing mM Mg ²⁺ and Ca ²⁺ was added to each well. Luciferase assays were performed using the LucLite kit using the manufacturer's instructions (Packard Instruments
). Luminescence is measured by SPC on the Packard Instruments Top-Counter.
The mode was quantified by counting.

Pharmaceutical Compositions: In another aspect, the present invention provides as active organism at least one compound of general formula (Ia) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Pharmaceutical compositions comprising the agents are included within the scope. Pharmaceutical compositions containing the compounds of the present invention are described in Remington: The Science and Practise
of Pharmacy, 19 ^th Ed., 1995.
The compositions may be in conventional forms, for example, capsules, tablets, aerosols, solutions, suspensions or topical applications.

A typical composition comprises a compound of formula (Ia) or a pharmaceutically acceptable acid addition salt thereof:
And a pharmaceutically acceptable excipient that can be a carrier or diluent or diluted by the carrier or encapsulated in a carrier that can be in the form of a capsule, sachet, paper or other container. Including. When producing tissue, conventional techniques for the preparation of pharmaceutical compositions can be used. For example, the active compound is usually mixed with or diluted with a carrier, or an ampoule,
It will be encapsulated in a carrier that is in the form of a capsule, sachet, paper, or other container. If the carrier acts as a diluent, it may be a solid, semi-solid or liquid material, which acts as a vehicle, excipient or medium for the active compound. The active compound can be adsorbed on a particulate solid container, for example, in a sachet.
Some examples of suitable carriers are water, saline, alcohol, polyethylene glycol, polyhydroxyethoxylated castor oil, peanut oil, olive oil, gelatin, lactose, clay, sucrose, cyclodextrin, amylose, magnesium stearate. Talc, gelatin, agar, pectin, acacia, stearic acid, or cellulose, silicic acid, fatty acids, fatty acid amines, lower alkyl ethers of fatty acid monoglycerides and diglycerides, pentaerythritol fatty acid esters, polyoxyethylene, hydroxymethylcellulose and polyvinylpyrrolidone. Similarly, the carrier or diluent includes any long-lasting material known in the art, such as glyceryl monostearate or glyceryl distearate, alone or mixed with a wax. The formulation may also contain wetting agents, emulsifying and suspending agents, preserving, sweetening or flavoring agents. The formulations of the present invention may also be formulated to provide quick, sustained, or delayed release of the active ingredient after administration to a patient by employing methods well known in the art. obtain.

The pharmaceutical compositions are sterilized and, if desired, do not adversely react with the active compound, auxiliaries, emulsifiers, salts for affecting osmotic pressure, buffers and / or coloring substances, and the like. Can be mixed with The route of administration may be any route which will effectively deliver the active compound to the appropriate or desired site of action, for example oral, nasal, pulmonary, pulmonary, transdermal or parenteral, for example rectal, subcutaneous, intravenous, It can be intraurethral, intramuscular, intranasal route, ophthalmic solution or ointment, and oral route is preferred.

If a solid carrier is used for oral administration, the preparation may be tabletted, placed in a hard gelatin capsule in powder or pellet form, or it can be in the form of a troche or lozenge. If a liquid carrier is used, the preparation may be in the form of a syrup, emulsion, soft gelatin capsule or sterile injectable liquid such as an aqueous or non-aqueous liquid suspension or solution.

For nasal administration, the formulation may comprise a compound of formula (Ia) dissolved or suspended in a liquid carrier, especially an aqueous carrier, for aerosol application. The carrier can include additives such as solubilizers such as propylene glycol, surfactants, absorption enhancers such as lecithin (phosphatidylcholine) or cyclodextrin, or preservatives such as parabens.

For parenteral administration, injection solutions or suspensions, preferably aqueous solutions, containing the active ingredients dissolved in polyhydroxylated castor oil, are particularly suitable. Capsules with talc and / or carbohydrate carriers or binders or the like are particularly suitable for oral application. Preferred carriers for tablets, dragees or capsules include lactose, corn starch and / or potato starch. A syrup or elixir may be used if a sweetening vehicle is used.

Typical tablets that can be prepared by conventional tableting techniques can include the following: Core: Active Compound (as free compound or a salt thereof) 5 mg Colloidal Silicon dioxide (Aerosil) 1.5 mg Cellulose , Microcrystalline (Avicel) 70mg Modified cellulose gum (Ac-Di-Sol) 7.5mg Magnesium stearate According to the formula Coating: HPMC about 9mg ^* Mywacett 9-40T about 0.9mg *: Used as plasticizer for film coating Acylated monoglycerides.

The compounds of the present invention may be administered to a mammal, especially a human, in need of treatment, prevention, elimination, alleviation or amelioration of a disease associated with the regulation of blood glucose. Such mammals also include animals, ie, domestic animals, such as domestic pets, and non-domestic animals, such as wild animals. The compounds of the present invention are effective over a wide dosage range. For example, in the treatment of an adult, a dose of about 0.05 to about 100 mg, preferably about 0.1 to about 100 mg, per day may be used. The most preferred dose is from about 0.1 mg to about 70 mg per day.
When choosing a regimen for a patient, it is sometimes necessary to begin with a dose of about 2 to about 70 mg per day, and if the condition is under control, about 0.1 to about 0.1 per day.
It may need to be lowered to doses as low as ~ 10 mg. The exact dose will depend on the mode of administration, the desired treatment, the form to be administered, the subject being treated and the weight of the subject being treated, and the choice and experience of the relevant physician or veterinarian.

Generally, the compounds of the invention will be dosed in unit doses comprising from about 0.1 to about 100 mg of active ingredient per unit dose and a pharmaceutically acceptable carrier. Usually, a suitable dosage form for oral, nasal, pulmonary or transdermal administration is from about 0.001 mg to about 100
mg, preferably from about 0.01 mg to about 50 mg of the compound of formula (Ia), and a pharmaceutically acceptable carrier or diluent.

In a further aspect, the present invention relates to a method for treating and / or preventing Type I or Type II diabetes. In yet another aspect, the invention relates to the treatment of type I or type II diabetes and / or
Or the use of one or more compounds of general formula (Ia) or a pharmaceutically acceptable salt thereof for the preparation of a medicament for prevention.

Any novel features or combinations thereof described herein are considered essential to the invention. The present invention will be described in further detail by the following examples. These examples are illustrative and do not limit the scope of the invention. Example 1 :

[0382]

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3- (4- [2- [5H-dibenzo [a, d] cyclohepten-5-yloxy
] -Ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester: a) Dibenzosuberenol (2.08 g, 10 mmol) was dissolved in anhydrous THF (20 ml) at O <0 > C. Sodium hydroxide (1.0 g of a 50% mineral oil dispersion, 20 mmol) was added. After 10 minutes, tert-butyl bromoacetate (4.0 g, 20.0 mmol) was added over 20 minutes and then stirred for 1 hour. The reaction mixture was quenched with water at 0 ° C. and the product was extracted with ethyl acetate. The combined extracts is dried (MgSO _4), and concentrated in vacuo. The product was redissolved in ether (20 ml) and lithium aluminum hydride (190 mg, 5.0 mmol) in ether (15 ml)
) Drip into buffer. The reaction was stirred at room temperature for 16 hours and quenched with water. The ether solution is washed with water, dried and concentrated in vacuo to give 1.3 g (50%) of 2
-(5H-Dibenzo [a, d] cyclohepten-5-yloxy) -ethanol was obtained.

B) Under a nitrogen atmosphere, 2- (5H-dibenzo [a, d] cyclohepten-5-yloxy) -ethanol (400 mg, 1.6 mmol), tributylphosphine (480 mg,
2.4 mmol) and 2-ethoxy-3- (4-hydroxy-phenyl) -propionic acid ethyl ester (380 mg, 1.6 mmol) were successively dissolved in anhydrous benzene (10 ml). Dipiperidine azodicarboxylate (ADDP) (480 mg, 2.4 mmol)
While stirring at 撹 拌 ° C, it was added to the solution. After 10 minutes, bring the reaction mixture to room temperature,
Stirring was continued for 2 hours. The mixture was added to water and the product was extracted with ethyl acetate. The combined organic phases is dried (MgSO _4), and concentrated in vacuo. The residue was purified by chromatography, eluting with ethyl acetate / hexane (1: 9) to give 350 mg (47%) of the title compound: MS472 (M ⁺ ).

Example 2 :

[0386]

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[0387] 3- (4- [2- (6,11-dihydro-dibenzo [b, e] thiepin-11-b yloxy) - ethoxy] - phenyl) -2-ethoxy - propionic acid Echiruesu Tel: a) 6, 11-dihydrodibenzo [b, e] thiepin-11-ol (1.14 g,
5 mmol) was dissolved in anhydrous THF (25 ml) at 0 ° C. Sodium hydride (0.24 g of a 50% mineral oil dispersion, 5 mmol) was added portionwise at 0 ° C. and then refluxed for 30 minutes.
Tert-butyl bromoacetate (980 mg, 5.0 mmol) in anhydrous THF (10 ml) was added over 20 minutes, followed by reflux for 30 minutes. The reaction mixture was quenched with water at 0 ° C. and the product was extracted with ether. The combined extracts were dried (MgSO _4), and concentrated in vacuo. The product was redissolved in ether and added dropwise to a suspension of lithium aluminum hydride (190 mg, 5.0 mmol) in ether (15 ml). The reaction was stirred at room temperature for 16 hours, quenched with water, cooled, and decalited.
And filtered through. The ether solution was washed with saturated NaCl, dried and purified by chromatography, eluting with ethyl acetate / dichloromethane (1:10) to give 850 mg (63%) of 2- (6,11-dihydrodibenzo [b, e] Thiepin-11-yloxy) -ethanol was obtained. ¹ H HMR (300MHz, CDCl ₃ ) δ3.5
5−3.70 (m, 2H), 3.75−3.85 (m, 2H), 4.00 (bs, 1H), 4.85 (bs, 1H), 5.55 (b
s, 1H), 7.03-7.13 (m, 3H), 7.13-7.48 (m, 5H).

B) Under a nitrogen atmosphere, 2- (6,11-dihydrodibenzo [b, e] thiepin-
11-yloxy) -ethanol (340 mg, 1.25 mmol), tributylphosphine (280 mg, 1.37 mmol) and 2-ethoxy-3- (4-hydroxy-phenyl)-
Ethyl propionate (330 mg, 1.37 mmol) was continuously dissolved in anhydrous benzene (10 ml). Dipiperidine azodicarboxylate (ADDP) (350mg, 1.37m
Mol) was added to the above solution with stirring at 0 ° C. After 10 minutes, the reaction mixture was brought to room temperature and stirring was continued for 16 hours. Heptane (10 ml) was added to the reaction mixture and the separated dihydro-ADDP was filtered. After evaporation of the solvent, the product was purified by chromatography, eluting with ethyl acetate / heptane (1: 4) to give 460 mg (75%) of the title compound: ¹ H HMR (300 MHz, CDCl ₃ ) δ1 .15 (t, 3H),
1.25 (t, 3H), 2.95 (d, 2H), 3.30-3.40 (m, 1H), 3.35-3.36 (m, 1H), 2.85 (t,
2H), 3.95 (t, 1H), 4.10-4.22 (m, 4H), 4.5-5.1 (bs, 1H), 5.60-5.75 (bs, 1H),
6.82 (d, 2H), 7.05-7.50 (m, 10H).

Example 3 :

[0390]

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[0391] 3- (4- [2- (6,11-dihydro-dibenzo [b, e] thiepin-11-b yloxy) - ethoxy] - phenyl) -2-ethoxy - propionic acid in ethanol (5 ml), 3- (4- [2- (6,11-dihydrodibenzo [b,
e] thiepin-11-yloxy) -ethoxy] -phenyl) -2-ethoxy-
Propionic acid ethyl ester (Example 2) (220 mg, 0.44 mmol) was added to 1N NaOH (0.9
ml, 0.9 mmol). The mixture was stirred at room temperature for 16 hours. The ethanol was evaporated and the pH was adjusted to pH 1 with 1N HCl. After extraction with dichloromethane, the product was purified by chromatography using dichloromethane / methanol (9: 1) as eluent to give 126 mg (62%) of the title compound: ¹ HH
MR (300MHz, CDCl ₃ ) δ 1.15 (t, 3H), 2.85-3.10 (m, 2H), 3.32-3.42 (m, 1H), 3
.52-3.65 (m, 1H), 2.85 (t, 2H), 3.95-4.05 (m, 1H), 4.10-4.22 (m, 2H), 4.5-5.
1 (bs, 1H), 5.60-5.75 (bs, 1H), 6.82 (d, 2H), 7.05-7.50 (m, 10H).

Example 4 :

[0393]

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[0394] 3- (4- [2- (6,11-dihydro-dibenzo [b, e] oxepin-11-yloxy) - ethoxy] - phenyl) -2-ethoxy - propionic acid Echirue ester: a) 6, 11 -Dihydrodibenzo [b, e] oxepin-11-ol (1.06 g
, 5 mmol) was dissolved in anhydrous THF (25 ml) at 0 ° C. Sodium hydride (0.24 g of a 50% mineral oil dispersion, 5 mmol) was added portionwise at 0 ° C. and then refluxed for 30 minutes. Tert-butyl bromoacetate (980 mg, 5.0 mmol) in anhydrous THF (10 ml) was added to 20
Was added over a minute and the mixture was stirred at 35 ° C. for 16 hours. The reaction mixture was quenched with water at 0 ° C. and the product was extracted with ether. The combined extracts were dried (MgSO _4), and concentrated in vacuo. The product was redissolved in ether and added dropwise to a suspension of lithium aluminum hydride (190 mg, 5.0 mmol) in ether (15 ml). The reaction was stirred at room temperature for 48 hours, quenched with water, cooled and filtered through Decalit. The ether solution was washed with saturated NaCl, dried and purified by chromatography, eluting with ethyl acetate / dichloromethane (1:10) to give 267 mg (21%) of 2- (6,11-dihydrodibenzo [b, e] Oxepin-11-yloxy) -ethanol was obtained.

B) Under a nitrogen atmosphere, 2- (6,11-dihydrodibenzo [b, e] oxepin-11-yloxy) -ethanol (256 mg, 1.0 mmol), tributylphosphine (223 mg, 1.1 mmol) and 2-ethoxy-3- (4-hydroxy-phenyl)
-Propionic acid ethyl ester (262 mg, 1.1 mmol) was added to anhydrous benzene (10 ml).
Dissolved continuously. Dipiperidine azodicarboxylate (ADDP) (278mg, 1.1
mmol) was added to the above solution with stirring at 0 ° C. After 10 minutes, the reaction mixture was brought to room temperature and stirring was continued for 16 hours. Heptane (10 ml) was added to the reaction mixture and the separated dihydro-ADDP was filtered. After evaporation of the solvent, the product is
Purification by chromatography, eluting with ethyl acetate / heptane (1: 4) gave 175 mg (37%) of the title compound: ¹ H HMR (300 MHz, CDCl ₃ ) δ 1.15 (t, 3H)
), 1.25 (t, 3H), 2.93 (d, 2H), 3.30-3.40 (m, 1H), 3.55-3.65 (m, 1H), 3.65-3.
75 (m, 1H), 3.78-3.88 (m, 1H), 3.95 (t, 1H), 4.10 (t, 2H), 4.15 (q, 2H), 4.
85 (d, 1H), 5.25 (s, 1H), 6.15 (d, 1H), 6.75 (d, 2H), 6.85-6.95 (m, 2H), 7.10
(d, 2H), 7.15-7.40 (m, 6H).

Example 5 :

[0397]

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3- (4- [2- (2,10-dichloro-12H-5,7-dioxa-diben
Zo [a, d] cycloocten-12-yloxy) -ethoxy] -phenyl)-
2-ethoxy-propionic acid ethyl ester: a) bis- (5-chloro-2-hydroxyphenyl)-in anhydrous DMF (340 ml)
To a solution of methane (24.4 g, 90.7 mmol) was added diiodomethane (25.5 g, 95.0 mmol) and potassium carbonate (18.2 g, 132 mmol). The mixture was stirred at 105 ° C. for 16 hours. The mixture was added to ice water (1200 ml) and stirred for 30 minutes. The product is isolated by filtration and washed with water and ethanol (200 ml) and 4
Suspended in a mixture of N NaOH (50 ml). The mixture was heated at 80 ° C. for 1 hour. The mixture was added to water (600 ml) and 21.45 g (84%) of 2,10-dichloro-12H-dibenzo [d, g] [1,3] -dioxocin was isolated by filtration.

B) 2,10-Dichloro-12H-dibenzo [d, g] [1,3] -dioxocin (21.4 g, 76.1 mmol) and N-bromosuccinimide (13.5 g) in tetrachloromethane (275 ml) , 76.1 mmol) in a solution of azabisisobutyronitrile (200 mg, 1
.2 mmol) was added. The mixture was heated at 80 C for 24 hours. Another 3 × azobisisobutyronitrile (200 mg, 1.2 mmol) was added within 24 hours. The mixture was filtered and the solution was concentrated under vacuum. The residue was added to dichloromethane (30ml) and ether (100ml). The mixture was filtered and the solution phase was concentrated under vacuum. The residue was subjected to flash chromatography, eluting with heptane / ethyl acetate (3: 1) and 7.4 g (27%) of 12-bromo-2,10-dichloro-12H-5,7-dioxadibenzo [A, d] cyclooctene was obtained.

C) 12-Bromo-2,10-dichloro-12H- in dichloromethane (10 ml)
5,7-dioxa-dibenzo [a, d] cyclooctene (900 mg, 2.5 mmol), 2
A mixture of -bromoethanol (3.75 g, 30 mmol) and potassium carbonate (1.0 g, 7.2 mmol) was heated at 120 ° C for 4 hours. The reaction mixture was concentrated under vacuum and water (25m
l) was added and the product was extracted with ethyl acetate (3 × 25 ml). The combined organic phases were dried (MgSO ₄ ), filtered and evaporated, 832 mg (82%)
Of 12- (2-bromo-ethoxy) -2,10-dichloro-12H-5,7-dioxa-dibenzo [a, d] cyclooctene.

D) 12- (2-Bromo-ethoxy) -2,10- in anhydrous toluene (6 ml)
Dichloro-12H-5,7-dioxa-dibenzo [a, d] cyclooctene (404 mg
, 1.0 mmol) and 2-ethoxy-3- (4-hydroxy-phenyl) -propionic acid ethyl ester (238 mg, 1.0 mmol) in a solution of potassium carbonate (276 mg, 2.0 mmol).
Mol) and 18-crown-6 (528 mg, 2.0 mmol). 60 of that mixture
Heated at C for 16 hours. The mixture was filtered and concentrated under vacuum. The residue,
Flash chromatography using toluene / ethyl acetate (19: 1) as eluent provided 297 mg (53%) of the title compound: ¹ H HMR (300 MHz, CDC
l ₃ ) δ 1.18 (t, 3H), 1.25 (t, 3H), 2.96 (d, 2H), 3.30-3.42 (m, 1H), 3.55-3.65
(m, 1H), 3.90-3.95 (m, 2H), 4.10 (t, 1H), 4.15-4.25 (m, 4H), 4.55 (d, 1H),
5.87 (d, 1H), 6.18 (s, 1H), 6.88-6.95 (m, 4H), 7.10-7.25 (m, 4H), 7.60 (d, 2H
).

Example 6 :

[0403]

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3- (4- [2- (2,10-dichloro-12H-5,7-dioxa-diben)
Zo [a, d] cycloocten-12-yloxy) -ethoxy] -phenyl) -2 -ethoxy-propionic acid: 3- (4- [2- (2,10-dichloro-12H-) in ethanol (8 ml). 5,
7-dioxa-dibenzo [a, d] cycloocten-12-yloxy) -ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester (Example 5) (450 m
g, 0.8 mmol) was added 1N NaOH (4.0 ml, 4.0 mmol). The mixture was stirred at room temperature for 16 hours. The sodium salt of the title compound was isolated by filtration and washed with ethanol / water to give 272 mg (61%): mp 240-241 ° C. ¹ H HMR
_{(300MHz, DMSO-d 6)} δ0.95 (t, 3H), 2.55-2.65 (m, 1H), 2.80-2.88 (m, 1H), 3.05
-3.15 (m, 1H), 3.48-3.60 (m, 2H), 3.80-3.90 (m, 2H), 4.15-4.25 (m, 2H), 4.65
(d, 1H), 5.90 (d, 1H), 6.13 (s, 1H), 6.85 (d, 2H), 7.05 (d, 2H), 7.15 (d, 2H)
, 7.23-7.30 (m, 2H), 7.55-7.58 (m, 2H).

Example 7 :

[0406]

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2-ethoxy-3- (4- [2- (2-methyl-9,10-dihydro-4H-
1-oxa-3-aza-benzo [f] azulen-4-yloxy) -ethoxy] -phenyl) -propionic acid ethyl ester: a) Ice of oxazole (1.08 g, 5.0 mmol) in anhydrous THF (50 ml). To the cooled solution was added sodium hydride (500 mg of a 60% mineral oil dispersion, 10 mmol). After stirring for 20 minutes, tert-butyl bromoacetate (1.95 g, 10 mmol) was added and stirred at room temperature for 1 hour. The reaction mixture was quenched with water and the product was extracted with ethyl acetate (2x50ml). Dry the combined organic phases (
MgSO _4), filtered and concentrated under vacuum, 1.47 g (90%) (2-methyl-9,
10-dihydro-4H-1-oxa-3-aza-benzo [f] azulen-4-yloxy) -acetic acid tert-butyl ester was obtained.

B) (2-Methyl-9,10-dihydro-4H-1) in anhydrous ether (10 ml)
To a solution of -oxa-3-aza-benzo [f] azulen-4-yloxy) -acetic acid tert-butyl ester (1.4 g, 4.3 mmol) in anhydrous ether (40 ml) lithium aluminum hydride (245 mg, 6.5 mmol) was added and stirred at room temperature for 1.5 hours. The reaction was quenched with water and the product was extracted with ether. The combined ether phases were dried (MgSO4), filtered and concentrated in vacuo to give 9
00 mg (91%) of 2- (2-methyl-9,10-dihydro-4H-1-oxa-3-
Aza-benzo [f] azulen-4-yloxy) -ethanol was obtained.

C) Under a nitrogen atmosphere, 2- (2-methyl-9,10-dihydro-4H-1-oxa-3-aza-benzo [f] azulen-4-yloxy) -ethanol (400 mg,
1.6 mmol), tributylphosphine (480 mg, 2.4 mmol) and 2-ethoxy-3
-(4-hydroxy-phenyl) -propionic acid ethyl ester (380 mg, 1.6 m
Mol) was continuously dissolved in anhydrous benzene (10 ml). Solid dipiperidine azodicarboxylate (ADDP) (480 mg, 2.4 mmol) was added to the solution at 0 ° C. with stirring. After 10 minutes, the reaction mixture was brought to room temperature and stirring was continued for 16 hours. The mixture was added to water and the product was extracted with ethyl acetate. The combined organic phases is dried (MgSO _4), and concentrated in vacuo. The residue was purified by chromatography eluting with petroleum ether / ethyl acetate (1: 1) to give 300 mg (40%).
%) Of the title compound: ¹ H HMR (300 MHz, CDCl ₃ ) δ 1.15 (t, 3H), 1.20 (t, 3H)
, 2.38 (s, 3H), 2.69-2.85 (m, 2H), 2.90-3.05 (m, 3H), 3.25-3.38 (m, 1H), 3.52
-3.65 (m, 1H), 3.65-3.75 (m, 1H), 3.75-3.90 (m, 2H), 3.95 (t, 1H), 4.05 (t,
2H), 4.15 (q, 2H), 5.25 (s, 1H), 6.75 (d, 2H), 7.10 (d, 2H), 7.13-7.30 (m,
4H).

Example 8 :

[0411]

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Embedded image 3- (4- [2- (10,11-dihydro-5H-dibenzo [a, d] cyclo
Butene-5-yloxy) -ethoxy] -phenyl) -2-ethoxy-propanoic acid ethyl ester: 5- (3-mesyloxypropylidene) -10,11-dihydro-5H-dibenzo [a, d] cycloheptene (5.0 g, 15.2 mmol), a mixture of ethyl-3- (4-hydroxyphenyl) -2-ethoxypropanoate (3.7 g, 15.5 mmol), potassium carbonate (2.9 g, 21 mmol) and dimethylformamide (10 ml) Was heated at 100 ° C. for 5 hours. Benzene (200 ml) and water (200 ml) were added and the phases were separated. The organic phase was dried and the solvent was evaporated under vacuum. The residue is purified by chromatography on silica gel, eluting with benzene / chloroform, to give first 2.5 g of 5-propenylidene-10,11-dihydro-5H-dibenzo [a, d] cycloheptene and In the meantime, 1.5 g (21%) of the title compound were obtained as an oil. ¹ H HMR (250MHz, CDCl ₃ ) δ7.10-7.35 (m, 10H), 6.85 (d, 2H),
6.06 (t, 1H), 4.27 (q, 2H), 4.07 (m, 3H), 3.68 (m, 1H), 3.45 (m, 1H), 3.17 (b
s, 4H), 3.06 (d, 2H), 2.69 (q, 2H), 1.27 (t, 3H), 0.99 (t, 3H).

Example 9 :

[0414]

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Embedded image 3- (4- [2- (10,11-dihydro-5H-dibenzo [a, d] cyclo
Puten-5-yloxy) -ethoxy] -phenyl) -2-ethoxypropanoic acid : 3- (4- [2- (10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yloxy) -ethoxy) ] -Phenyl) -2-ethoxy-propanoic acid ethyl ester (Example 8) (1.5 g, 3.2 mmol) was dissolved in ethanol (30 ml) and 20% sodium hydroxide (3 ml) was added. After 3 days, the ethanol was evaporated under vacuum, water (50 ml) and hydrochloric acid (2 ml) were added, and the mixture was extracted with dichloromethane. The organic phase is dried (MgSO _4), and evaporated in vacuo the solvent. The residue (1.1 g, 78%) was dissolved in ethanol and treated with (L) -lysine monohydrate (0.41 g). The ethanol was evaporated and the residue was triturated with diethyl ether. The crystalline product was filtered and dried in air. This provided the title compound as a salt with (L) lysine (dihydrate). MP = 148-150 ° C. ¹ H HMR (250MHz, DMSO-d ₆ ) δ7.00-7.35 (m, 10H),
6.75 (bd, J = 8.2Hz, 2H), 6.26 (bs, 8H), 5.91 (t, J = 6.6Hz, 1H), 4.02 (t, J = 6.2
Hz, 2H), 3.76 (m, 1H), 3.59 (m) +3.31 (m), 2H, 3.07 (bs, 4H), 2.70-2.95 (m, 4H
), 2.51 (bq, 2H), 1.66 (bm, 6H), 1.03 (t, J = 7.2Hz, 3H).

Example 10 :

[0417]

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3- (4- [2-([10,11-dihydro-5H-dibenzo [a, d] cyclo
Heptene-5-yl] - methyl - amino) - ethoxy] - phenyl) -2-ethoxy Kishipuropan acid ethyl ester: 5- (methylamino) 10,11-dihydro -5H- dibenzo [a, d] cycloheptene hydrochloride (1.8 g, 6.94 mmol), ethyl-3- (4-bromoethoxyphenyl) -2-ethoxypropanoate (2.4 g, 6.95 mmol), potassium carbonate (2
.9 g, 21 mmol) and dimethylformamide (7 ml) was heated at 100 ° C. for 5 hours. Benzene (200 ml) and water (200 ml) were added and the phases were separated. The organic phase was dried and the solvent was evaporated under vacuum. The residue was purified by chromatography on silica gel, eluting with benzene / chloroform to give 2.2 g (
(65%) of the title compound as an oil. R _f = 0.60 (chloroform / ethanol /
Ammonia = 20: 2: 0.1).

Example 11 :

[0420]

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3- (4- [2-([10,11-dihydro-5H-dibenzo [a, d] cyclo
Heptene-5-yl] - methyl - amino) - ethoxy] - phenyl) -2-ethoxy Kishipuropan acid: 3- (4- [2 - ([10,11-dihydro -5H- dibenzo [a, d] cycloheptene - 5-yl] -methyl-amino) -ethoxy] -phenyl) -2-ethoxypropanoic acid ethyl ester (Example 10) (1.5 g, 3.07 mmol) was dissolved in ethanol (20 ml) and 20% Sodium hydroxide (2 ml) was added. 6
After a day, the ethanol was evaporated under vacuum, water (50 ml) and acetic acid (2 ml) were added, and the mixture was extracted with dichloromethane. Dry the organic phase (MgSO ₄
) And the solvent was evaporated under vacuum. The residue (1.4 g) was dissolved in acetone and neutralized by a solution of hydrogen chloride in diethyl ether. The solvent was evaporated and the residue was triturated with diethyl ether to give 1.5 g (74%) of the title compound as an amorphous solid (1/2 hydrate). ¹ H HMR (250MHz, DMSO-d ₆ ) δ 10.50 (bs, 1H), 7.6
0 (bs) + 7.10-7.50 (m, 10H), 6.87 (d, J = 7.9Hz, 2H), 5.84 (bd, J = 7.0Hz, 1H), 4
.49 (bs, 2H), 4.00 (t, J = 5.6Hz; + bm, 3H), 3.30-3.69 (m + m, 4H), 2.80-3.10 (s +
bm, 7H), 1.07 (t, J = 7.2Hz, 3H).

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 31/357 A61K 31/357 31/38 31/38 31/423 31/423 A61P 3/04 A61P 3 / 04 3/06 3/06 3/10 3/10 9/00 9/00 9/10 9/10 9/12 9/12 13/12 13/12 15/00 15/00 17/06 17/06 19 / 08 19/08 25/28 25/28 43/00 105 43/00 105 C07C 59/72 C07C 59/72 217/54 217/54 C07D 263/52 C07D 263/52 313/12 313/12 321/12 321/12 337/12 337/12 (81) Designated countries EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT , SE), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID , IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, (72) Invention NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW Jepessen, Rone Denmark, 28-30, Burkom, Burmese, Marmosevie 121 (72) Invention Brie, Paul Stanley, Denmark 2400, Denmark 2400 Kebenhavn Embeh, Höltholms All 48 (72) Inventor Sauerberg, Per Denmark, Denmark-3520 Farm, Silenbenget 27 F term (reference) 4C056 AA01 AB01 AC02 AD02 AE03 CA02 CC01 CD06 4C062 JJ37 4C086 AA01 AA02 AA03 BA10 BA16 BC70 DA27 MA01 MA02 MA03 MA04 MA05 NA14 ZA15 ZA36 ZA45 ZA70 ZA81 ZA89 ZA96 ZB21 ZC33 ZC35 ZC41 4C206 AA01 AA02 AA03 ZA41 MA05 MA04 MA21 ZA89 ZA96 ZB21 ZC33 ZC35 ZC41 4H006 AA01 AA03 AB20 AB24 BJ50 BP20 BP30 BS10 BU44 KC14

Claims (71)

[Claims] 1. The following formula (Ia):[Where R¹, R^Two, R^ThreeAnd R^FourAre independently hydrogen, halogen, perhalomethy
, Hydroxy, nitro, cyano, formyl, or C_1-12Alkyl, C_4-12Arche
Ninyl, C_2-12Alkenyl, C_2-12Alkynyl, C_1-12Alkoxy, aryl, a
Reeloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl,
Heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyl
Luoxy, hydroxy C_1-12Alkyl, amino, acylamino, C_1-12Alkyria
Mino, arylamino, aralkylamino, aminoC_1-12Alkyl, C_1-12Arco
Xycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C_1-12
Alkoxy C_1-12Alkyl, aryloxy C_1-12Alkyl, aralkoxy C_1-12
Alkyl, C_1-12Alkylthio, Thio C_1-12Alkyl, C_1-12Alkoxycarboni
Ruamino, aryloxycarbonylamino, aralkoxycarbonylamino,
-COR¹¹, Or -SO_TwoR¹²Where R¹¹And R¹²Are independent of each other, hydroxy
, Halogen, perhalomethyl, C_1-6Alkoxy or amino, one or more
Number C_1-6Optionally substituted with alkyl, perhalomethyl or aryl
Optionally, one or more halogen, perhalomethyl, hydroxy
, Nitro or cyano; or R¹And R^Two, R^TwoAnd R^ThreeAnd / or R^ThreeAnd R^FourIs one or more C_1-6By alkyl
Ring A represents a 5- to 6-membered ring, optionally substituted with one or more halogen, perhalogene,
Chill, hydroxy, nitro, cyano, formyl, or C_1-12Alkyl, C_4-12Al
Keninyl, C_2-12Alkenyl, C_2-12Alkynyl, C_1-12Alkoxy, aryl,
Aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl
, Heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, a
Siloxy, hydroxy C_1-12Alkyl, amino, acylamino, C_1-12Alkyl
Amino, arylamino, aralkylamino, aminoC_1-12Alkyl, C_1-12Al
Coxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, C_{1-1 Two} Alkoxy C_1-12Alkyl, aryloxy C_1-12Alkyl, aralkoxy C_1-12 Alkyl, C_1-12Alkylthio, Thio C_1-12Alkyl, C_1-12Alkoxycarboni
Ruamino, aryloxycarbonylamino, aralkoxycarbonylamino,
-COR¹¹, Or -SO_TwoR¹²Where R¹¹And R¹²Are independent of each other
Droxy, halogen, perhalomethyl, C_1-6Alkoxy or amino and 1
Or multiple C_1-6Optionally substituted by alkyl, perhalomethyl or aryl
Optionally, one or more halogen, perhalomethyl, hydro
X is substituted by xy, nitro or cyano; X is a valence bond,-(CHR⁹)-,-(CHR⁹) -CH_Two-, -CH = CH-, -O-, -O- (CHR⁹)-, -S-
(CHR⁹)-,-(NR⁹) -CH_Two-,-(CHR⁹) -CH = CH-,-(CHR⁹) -CH_Two-CH_Two-,-(C = O)-, -O-CH_Two-
O-,-(NR⁹) -S (O_Two)-,-(NR⁹)-, -CH = (CR⁹)-,-(CO)-(CHR⁹)-, -CH_Two-(SO)-, -S-,
-(SO)-,-(SO_Two)-, -CH_Two-(SO_Two)-, -CH_Two-O-CH_Two-And where R⁹Is hydrogen, halo
Gen, hydroxy, nitro, cyano, formyl, C_1-12Alkyl, C_1-12Alkoki
Si, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl,
Heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkyl
Si, acyl, acyloxy, hydroxyalkyl, amino, acylamino, C_{1-1 Two} Alkylamino, arylamino, aralkylamino, aminoC_1-12Alkyl,
C_1-12Alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbo
Nil, C_1-12Alkoxy C_1-12Alkyl, aryloxy C_1-12Alkyl, aral
Koxy C_1-12Alkyl, C_1-12Alkylthio, Thio C_1-12Alkyl, C_1-12Alkoki
Cicarbonylamino, aryloxycarbonylamino, aralkoxycarboni
Luamino, -COR¹³, Or -SO_TwoR¹⁴And where R¹³And R¹⁴Are independent of each other,
Hydroxy, halogen, C_1-6Alkoxy or amino and one or more C_1-6 Selected from those optionally substituted by alkyl, perhalomethyl or aryl.
Z is -CH_Two-, -O-, -S-,> SO_Two,> NR^FifteenAnd where R^FifteenIs hydrogen, halogen,
Hydroxy, nitro, cyano, formyl, C_1-12Alkyl, C_1-12Alkoxy, a
Reel, aryloxy, aralkyl, aralkoxy, heterocyclyl, hetero
Aryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, a
Sil, acyloxy, hydroxyalkyl, amino, acylamino, C_1-12Al
Killamino, arylamino, aralkylamino, aminoC_1-12Alkyl, C_1-12 Alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl,
C_1-12Alkoxy C_1-12Alkyl, aryloxy C_1-12Alkyl, aralkoxy C _1-12 Alkyl, C_1-12Alkylthio, Thio C_1-12Alkyl, C_1-12Alkoxycal
Bonylamino, aryloxycarbonylamino, aralkoxycarbonylamino
No, -COR¹⁶, Or -SO_TwoR¹⁷And where R¹⁶And R¹⁷Are independent of each other,
Xy, halogen, C_1-6Alkoxy or amino and one or more C_1-6Archi
Q is selected from -O-, -S-,> NR¹⁸And where R¹⁸Is hydrogen or C_1-6Ar is arylene, heteroarylene, or a divalent heterocyclic group;
Multiple C_1-6Represents optionally substituted by alkyl or aryl; R^FiveIs hydrogen, hydroxy, halogen, C_1-12Alkoxy, C_1-12Alkyl, C_{4-1 Two} -Alkenyl, C_2-12Alkenyl, C_2-12Represents alkynyl or aralkyl;
Optionally, one or more halogen, perhalomethyl, hydroxy, nitro or
Substituted by ano; or R^FiveIs R⁶Forms a bond with; R⁶Is hydrogen, hydroxy, halogen, C_1-12Alkoxy, C_1-12Alkyl, C_{4-1 Two} -Alkenyl, C_2-12Alkenyl, C_2-12Alkynyl, acyl or aralkyl
Optionally; one or more halogen, perhalomethyl, hydroxy, nitro
R or substituted by cyano; or R⁶Is R^FiveForms a bond with; R⁷Is hydrogen, C_1-12Alkyl, C_4-12-Alkenyl, C_2-12Alkenyl, C_2-12 Alkynyl, aryl, aralkyl, C_1-12Alkoxy C_1-12Alkyl, C_1-12A
Lucoxycarbonyl, aryloxycarbonyl, C_1-12Alkylaminocarbo
Nil, arylaminocarbonyl, acyl, heterocyclyl, heteroaryl or
Represents a heteroaralkyl group; optionally, one or more halogen, perhalomethy
R, substituted by hydroxy, nitro or cyano; R⁸Is hydrogen, C_1-12Alkyl, C_4-12-Alkenyl, C_2-12Alkenyl, C_2-12 Alkynyl, aryl, aralkyl, heterocyclyl, heteroaryl or hete
Represents a lower aralkyl group; optionally, one or more halogen, perhalomethyl
, Hydroxy, nitro or cyano; Y is oxygen, sulfur or NR^TenWhere R^TenIs hydrogen, C_1-12Alkyl, Ally
, Hydroxy C_1-12Represents an alkyl or aralkyl group, or Y is NR^TenIf it is
, R⁸And R^TenIs one or more C_1-65- or 6-membered optionally substituted by alkyl
And n is an integer ranging from 1 to 4, or a pharmaceutically acceptable compound
Salt. 2. R¹, R^Two, R^ThreeAnd R^FourBut independently of each other, hydrogen, halogen,
Luhalomethyl, hydroxy, cyano, or C_1-7Alkyl, C_4-7Alkenyl, C_{Two -7} Alkenyl, C_2-7Alkynyl, C_1-7Alkoxy, aryl, aryloxy,
Aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl
, Heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydr
Roxy C_1-7Alkyl, amino, acylamino, C_1-7Alkylamino, arylua
Mino, aralkylamino, amino C_1-7Alkyl, C_1-7Alkoxycarbonyl, a
Reeloxycarbonyl, aralkoxycarbonyl, C_1-7Alkoxy C_1-7Archi
, Aryloxy C_1-7Alkyl, aralkoxy C_1-7Alkyl, C_1-7Alkyl
Oh, Thio C_1-7Alkyl, C_1-7Alkoxycarbonylamino, aryloxycar
Bonylamino, aralkoxycarbonylamino, -COR¹¹, Or -SO_TwoR¹²Represents
Where R¹¹And R¹²Are independently of each other hydroxy, perhalomethyl, C_1-6Arco
Xy, or one or more C_1-6Optional with alkyl, perhalomethyl or aryl
Selected from amino substituted; optionally, one or more halogens, perhalo
Substituted by methyl, hydroxy, nitro or cyano; or R¹And R^Two, R^TwoAnd R^ThreeAnd / or R^ThreeAnd R^FourIs one or more C_1-6By alkyl
Claims that can form an optionally substituted ring containing 5 to 7 carbon atoms.
Item 7. The compound according to Item 1. 3. R¹, R^Two, R^ThreeAnd R^FourBut independently of each other, hydrogen, halogen,
Luhalomethyl, hydroxy, cyano, or C_1-7Alkyl, C_4-7Alkenyl, C_{Two -7} Alkenyl, C_2-7Alkynyl, C_1-7Alkoxy, aryl, aryloxy,
Aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl
, Heteroaryloxy, heteroaralkoxy, acyl, hydroxy C_1-7Al
Kill, amino, acylamino, C_1-7Alkylamino, arylamino, aralkyl
Ruamino, amino C_1-7Alkyl, C_1-7Alkoxy C_1-7Alkyl, aryloxy
C_1-7Alkyl, aralkoxy C_1-7Alkyl, C_1-7Alkylthio, Thio C_1-7Archi
, C_1-7Alkoxycarbonylamino, aryloxycarbonylamino or
3. The compound according to claim 1, which represents ralkoxycarbonylamino. 4. R¹, R^Two, R^ThreeAnd R^FourBut independently of each other, hydrogen, halogen,
Luhalomethyl, hydroxy, cyano, or C_1-7Alkyl, C_4-7Alkenyl, C_{Two -7} Alkenyl, C_2-7Alkynyl, C_1-7Alkoxy, aryl, aryloxy,
Aralkyl, aralkoxy, acyl, hydroxy C_1-7Alkyl, amino, C_1-7A
Alkylamino, arylamino, aralkylamino, C_1-7Alkoxy C_1-7Archi
, Aryloxy C_1-7Alkyl, aralkoxy C_1-7Alkyl or C_1-7Archi
A compound according to any one of claims 1 to 3 representing luthio. 5. R¹, R^Two, R^ThreeAnd R^FourBut independently of each other, hydrogen, halogen,
Luhalomethyl, or C_1-7Alkyl, C_4-7Alkenyl, C_2-7Alkenyl, C_2-7A
Lucinyl, aryl, aralkyl, hydroxy C_1-7Alkyl, C_1-7Alkoxy C_{1 -7} Alkyl, aryloxy C_1-7Alkyl or aralkoxy C_1-7Table showing alkyl
A compound according to any one of claims 1 to 4. 6. The compound according to claim 1, wherein R ¹ , R ² , R ³ and R ⁴ independently of one another represent hydrogen, halogen or C _1-7 alkyl. 7. The compound according to claim 1, wherein R ¹ , R ² , R ³ and R ⁴ independently of one another represent hydrogen, chlorine or methyl. 8. Ring A represents a 5- to 6-membered ring, optionally having one or more halogen, perhalomethyl, hydroxy, cyano, or C _1-7 alkyl, C _4-7 alkenyl, C _{2- 7} alkenyl, C _2-7 alkynyl, C _1-7 alkoxy, aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy, acyl, acyloxy, hydroxy C _1-7 alkyl, amino, acylamino, C _1-7 alkylamino, arylamino, aralkylamino, amino C _1-7 alkyl, C _1-7 alkoxy C _1-7 alkyl, aryloxy C _1-7 alkyl, aralkoxy C _1-7 alkyl, C _1-7 alkylthio, thio C _1-7 alkyl, C _1-7 alkoxycarbonylamino, aryloxycarbonylamino, aralkoxycarbonyl carbonitrile Arylamino, substituted by -COR ^11, or -SO ₂ R ^12, wherein R ¹¹ and R ¹² independently of one another, hydroxy, perhalomethyl,
Selected from C _1-6 alkoxy, or amino optionally substituted with one or more C _1-6 alkyl, perhalomethyl or aryl; optionally substituted with one or more halogen, perhalomethyl, hydroxy, or cyano A compound according to any one of claims 1 to 7. 9. Ring A represents a 5- to 6-membered ring, and optionally one or more halogen
, Perhalomethyl, hydroxy, cyano, or C_1-7Alkyl, C_4-7Alkenini
, C_2-7Alkenyl, C_2-7Alkynyl, C_1-7Alkoxy, aryl, arylo
Xy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroa
Aralkyl, heteroaryloxy, heteroaralkoxy, acyl, hydroxy C_{1 -7} Alkyl, amino, acylamino, C_1-7Alkylamino, arylamino, a
Aralkylamino, amino C_1-7Alkyl, C_1-7Alkoxy C_1-7Alkyl, aryl
Oxy C_1-7Alkyl, aralkoxy C_1-7Alkyl, C_1-7Alkylthio, Thio C_1-7 Alkyl, C_1-7Alkoxycarbonylamino, aryloxycarbonylamino
Or substituted by aralkoxycarbonylamino.
A compound according to claim 1. 10. Ring A represents a 5- to 6-membered ring, optionally having one or more halo
Gen, perhalomethyl, hydroxy, cyano, or C_1-7Alkyl, C_4-7Alkene
Nil, C_2-7Alkenyl, C_2-7Alkynyl, C_1-7Alkoxy, aryl, aryl
Oxy, aralkyl, aralkoxy, acyl, hydroxy C_1-7Alkyl, amino
, C_1-7Alkylamino, arylamino, aralkylamino, C_1-7Alkoxy C_{1 -7} Alkyl, aryloxy C_1-7Alkyl, aralkoxy C_1-7Alkyl or C_{1 -7} 10. A compound according to any one of claims 1 to 9 substituted by alkylthio. 11. Ring A represents a 5- to 6-membered ring, optionally having one or more halogen, perhalomethyl, or C _1-7 alkyl, C _4-7 alkenyl, C _2-7 alkenyl, C Substituted by _2-7 alkynyl, C _1-7 alkoxy, aryl, aralkyl, hydroxy C _1-7 alkyl, C _1-7 alkoxy C _1-7 alkyl, aryloxy C _1-7 alkyl, or aralkoxy C _1-7 alkyl The compound according to any one of claims 1 to 10, wherein 12. The compound according to claim 1, wherein ring A represents a 5- to 6-membered ring optionally substituted by one or more chlorine or methyl groups. 13. X is a valence bond,-(CHR ⁹ )-,-(CHR ⁹ ) -CH _2- , -CH = CH-, -O
-, -O- (CHR ⁹ )-, -S- (CHR ⁹ )-,-(NR ⁹ ) -CH ₂ -,-(CHR ⁹ ) -CH = CH-,-(CHR ⁹ ) -CH _2- CH _2-
,-(C = O)-, -O-CH ₂ -O-,-(NR ⁹ ) -S (O ₂ )-,-(NR ⁹ )-, -CH = (CR ⁹ )-,-(CO )-(CHR ⁹ )-,
-CH _2- (SO)-, -S-,-(SO)-,-(SO ₂ )-, -CH _2- (SO ₂ )-, or -CH ₂ -O-CH _2- ,
Where R ⁹ is hydrogen, halogen, hydroxy, C _1-7 alkyl, C _1-12 alkoxy,
Aryl, aryloxy, aralkyl, aralkoxy, heterocyclyl, heteroaryl, heteroaralkyl, heteroaryloxy, heteroaralkoxy,
Hydroxyalkyl, amino, acylamino, C _1-7 alkylamino, arylamino, aralkylamino, amino C _1-7 alkyl, C _1-7 alkoxy C _1-12 alkyl, aryloxy C _1-7 alkyl, aralkoxy C _1- The compound according to any one of claims 1 to 12, which is ₇ alkyl, C _1-12 alkylthio, thio C _1-7 alkyl, C _1-7 alkoxycarbonylamino, aryloxycarbonylamino, or aralkoxycarbonylamino. 14. X is a valence bond,-(CHR ⁹ )-,-(CHR ⁹ ) -CH _2- , -CH = CH-, -O
-, -O- (CHR ⁹ )-, -S- (CHR ⁹ )-,-(NR ⁹ ) -CH ₂ -,-(CHR ⁹ ) -CH = CH-,-(CHR ⁹ ) -CH _2- CH _2-
,-(C = O)-, -O-CH ₂ -O-,-(NR ⁹ ) -S (O ₂ )-,-(NR ⁹ )-, -CH = (CR ⁹ )-,-(CO )-(CHR ⁹ )-,
-CH _2- (SO)-, -S-,-(SO)-,-(SO ₂ )-, -CH _2- (SO ₂ )-, or -CH ₂ -O-CH _2- ,
Where R ⁹ is hydrogen, halogen, hydroxy, C _1-7 alkyl, aryl, aralkyl, C _1-7 alkoxy C _1-12 alkyl, aryloxy C _1-7 alkyl, or aralkoxy C _1-7 alkyl. A compound according to any one of claims 1 to 13. 15. X is a valence bond,-(CHR ⁹ )-,-(CHR ⁹ ) -CH _2- , -CH = CH-, -O
-, -O- (CHR ⁹ )-, -S- (CHR ⁹ )-,-(NR ⁹ ) -CH ₂ -,-(CHR ⁹ ) -CH = CH-,-(CHR ⁹ ) -CH _2- CH _2-
,-(C = O)-, -O-CH ₂ -O-,-(NR ⁹ ) -S (O ₂ )-,-(NR ⁹ )-, -CH = (CR ⁹ )-,-(CO )-(CHR ⁹ )-,
-CH _2- (SO)-, -S-,-(SO)-,-(SO ₂ )-, -CH _2- (SO ₂ )-, or -CH ₂ -O-CH _2- ,
The compound according to any one of claims 1 to 14, wherein R ⁹ is hydrogen. 16. X is a valence bond,-(CHR ⁹ )-,-(CHR ⁹ ) -CH _2- , -CH = CH-, -O
-, -O- (CHR ⁹ )-, -S- (CHR ⁹ )-,-(NR ⁹ ) -CH _2- , -O-CH ₂ -O-,-(NR ⁹ )-, -S-, -(SO)-
Or -CH ₂ -O-CH ₂ - and is, where R ⁹ is any of claims 1 to 15 is hydrogen 1
Item. 17. X is a valence bond,-(CHR ⁹ )-,-(CHR ⁹ ) -CH _2- , -CH = CH-, -O
-, -O- (CHR ⁹ )-, -S- (CHR ⁹ )-,-(NR ⁹ ) -CH _2- , -O-CH ₂ -O-,-(NR ⁹ )-, -S- or -CH ₂ -O-CH ₂ - and is, where R ⁹ is the compound of any one of claims 1 to 16 is hydrogen. 18. X is a valence bond,-(CHR ⁹ )-,-(CHR ⁹ ) -CH _2- , -CH = CH-, -O
^{-, -O- (CHR 9) -} , -S- (CHR 9) -, -O-CH 2 -O-, or -S-, wherein R ⁹ is claims 1-17 is hydrogen The compound according to any one of the above. 19. Z is, -CH ₂ -, -O-, -S- or> is NR ^15, where R ¹⁵ is hydrogen, C _1-12 alkyl, C _1-7 alkoxy, aralkyl, aralkoxy , hydroxyalkyl, amino C _1-7 alkyl, C _1-12 alkoxy C _1-7 alkyl, aryloxy C _1-7 alkyl, or aralkoxy C _1-7 according to any one of claims 1 to 18 is alkyl Compound. 20. Z is, -CH ₂ -, -O-, -S- or> is NR ^15, where R ¹⁵ is The compound of any one of claims 1 to 19 is hydrogen. 21. The compound according to any one of claims 1 to 20, wherein Z is -O-. 22. Q is, -O-, -S- or> is NR ^18, where R ¹⁸ is A compound according to any one of claims 1 to 21 is hydrogen or methyl. 23. Q is, -O- or> is NR ^18, where R ¹⁸ is A compound according to any one of claims 1 to 22 is methyl. 24. The compound of any one of claims 1 to 23, wherein Ar represents arylene optionally substituted with one or more C _1-6 alkyl or aryl. 25. The compound according to claim 1, wherein Ar represents phenyl. 26. R^FiveIs hydrogen, hydroxy, halogen, C_1-7Alkoxy, C_{1 -7} Alkyl, C_4-7-Alkenyl, C_2-7Alkenyl, C_2-7Alkynyl or aral
Represents a kill, or R^FiveIs R⁶26. A compound as claimed in any one of claims 1 to 25 which forms a bond with
A compound as described. 27. The compound according to claim 1, wherein R ⁵ represents hydrogen or R ⁵ forms a bond with R ⁶ . 28. R^FiveIs hydrogen, hydroxy, halogen, C_1-7Alkoxy, C_{1 -7} Alkyl, C_4-7-Alkenyl, C_2-7Alkenyl, C_2-7Alkynyl or aral
Represents a kill, or R^FiveIs R⁶28. A bond according to any one of claims 1 to 27 forming a bond with
A compound as described. 29. The compound according to claim 1, wherein R ⁵ represents hydrogen or R ⁵ forms a bond with R ⁶ . 30. R ⁷ is hydrogen, C _1-7 alkyl, C _4-7 -alkenyl, C _2-7 alkenyl, C _2-7 alkynyl, aryl, aralkyl, C _1-7 alkoxy C _1-7 alkyl , C _1-7 alkoxycarbonyl, aryloxycarbonyl, C _1-7 alkylaminocarbonyl, arylaminocarbonyl, acyl, heterocyclyl, a compound according to any one of claims 1 to 29 represents heteroaryl or heteroaralkyl group. 31. The compound according to claim 1, wherein R ⁷ represents hydrogen, C _1-7 alkyl, C _4-7 -alkenyl, C _2-7 alkenyl or C _2-7 alkynyl. . 32. The compound according to any one of claims 1 to 31, wherein R ⁷ represents C _1-2 alkyl. 33. R ⁸ represents a hydrogen, C _1-7 alkyl, C _4-7 -alkenyl, C _2-7 alkenyl, C _2-7 alkynyl, aryl, aralkyl, heterocyclyl, heteroaryl or heteroaralkyl group. Optionally, one or more halogens;
4. Substituted by perhalomethyl, hydroxy, nitro or cyano.
3. The compound according to any one of 2. 34. The method according to claim 1, wherein R ⁸ represents hydrogen, C _1-7 alkyl, C _4-7 -alkenyl, C _2-7 alkenyl, C _2-7 alkynyl, aryl or aralkyl.
The compound according to any one of the above. 35. The compound according to claim 1, wherein R ⁸ represents hydrogen or C _1-2 alkyl. 36. Y is oxygen, sulfur or NR ¹⁰ wherein R ¹⁰ is hydrogen, C _1-7 alkyl, aryl, hydroxy C _1-7 alkyl or aralkyl.
36. The compound according to any one of -35. 37. The compound according to any one of claims 1 to 36, wherein Y represents oxygen. 38. The compound according to any one of claims 1 to 37, wherein n is an integer ranging from 2 to 3. 39. The compound according to any one of claims 1 to 38, wherein A is benzo. 40. The compound according to any one of claims 1 to 39, wherein A is a 5-membered ring containing S. 41. The method according to claim 1, wherein X is — (CHR ⁹ ) —CH ₂ —, wherein R ⁹ is H.
41. The compound according to any one of claims 40. 42. X is, -O- (CHR ⁹⁾ - a, where in R ⁹ is claim 1 which is H
42. The compound according to any one of 41. 43. X is -S- (CHR ⁹ )-, wherein R ⁹ is H.
43. The compound according to any one of 42. 44. The compound according to any one of claims 1 to 43, wherein X is —O—CH ₂ —O—. 45. The compound according to any one of claims 1 to 44, wherein Q is -O-. 46. The compound according to any one of claims 1 to 45, wherein Q is -S-. 47. Q is> is NR ^18, where R ¹⁸ is C _1-6 alkyl The compound of any one of claims 1-46 is preferably methyl. 48. The compound according to any one of claims 1 to 47, wherein Z is -O-. 49. The compound according to any one of claims 1 to 48, wherein n is 2. 50. The compound according to any one of claims 1 to 49, wherein Q is -O-. 51. The compound according to any one of claims 1 to 50, wherein Ar is phenylene. 52. The compound according to any one of claims 1 to 51, wherein R ⁵ is H. 53. The compound according to any one of claims 1 to 52, wherein R ⁶ is H. 54. The compound according to any one of claims 1 to 52, wherein R ⁷ is ethyl. 55. The compound according to any one of claims 1 to 54, wherein R ⁸ is H. 56. 2-ethoxy-3- (4- [2- [2-methyl-5H-di
Benzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)
-Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [2-ethyl-5H-dibenzo [a, d] cyc]
Rohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate
Esters, 2-ethoxy-3- (4- [2- [2-propyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-ethoxy-3- (4- [2- [2-phenyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-ethoxy-3- (4- [2- [2-benzyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-ethoxy-3- (4- [2- [2-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propion
Acid ethyl ester, 2-ethoxy-3- (4- [2- [3-methyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate
Esters, 2-ethoxy-3- (4- [2- [3-ethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate
Esters, 2-ethoxy-3- (4- [2- [3-propyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-ethoxy-3- (4- [2- [3-phenyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-ethoxy-3- (4- [2- [3-benzyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-ethoxy-3- (4- [2- [3-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propion
Acid ethyl ester, 3- (4- [2- [2,8-dimethyl-5H-dibenzo [a, d] cyclohepte
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
Ethyl ester, 3- (4- [2- [2,8-diethyl-5H-dibenzo [a, d] cyclohepte
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
Ethyl ester, 3- (4- [2- [2,8-dipropyl-5H-dibenzo [a, d] cyclohep]
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid ethyl ester, 3- (4- [2- [2,8-diphenyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid ethyl ester, 3- (4- [2- [2,8-dibenzyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid ethyl ester, 3- (4- [2- [2,8-diphenylethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-pro
Pionic acid ethyl ester, 3- (4- [2- [2,7-dimethyl-5H-dibenzo [a, d] cyclohepte)
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
Ethyl ester, 3- (4- [2- [2,7-diethyl-5H-dibenzo [a, d] cyclohepte
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
Ethyl ester, 3- (4- [2- [2,7-dipropyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid ethyl ester, 3- (4- [2- [2,7-diphenyl-5H-dibenzo [a, d] cyclohep]
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid ethyl ester, 3- (4- [2- [2,7-dibenzyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid ethyl ester, 3- (4- [2- [2,7-diphenylethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-pro
Pionic acid ethyl ester, 3- (4- [2- [3,7-dimethyl-5H-dibenzo [a, d] cyclohepte)
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
Ethyl ester, 3- (4- [2- [3,7-diethyl-5H-dibenzo [a, d] cyclohepte
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
Ethyl ester, 3- (4- [2- [3,7-dipropyl-5H-dibenzo [a, d] cyclohep]
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid ethyl ester, 3- (4- [2- [3,7-diphenyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid ethyl ester, 3- (4- [2- [3,7-dibenzyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid ethyl ester, 3- (4- [2- [3,7-diphenylethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-pro
Pionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-ethyl-2-methyl-5H-dibenzo)
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-propyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-phenyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-benzyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-methyl-2-ethyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-propyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-phenyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-benzyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-methyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-ethyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-phenyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-benzyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
Ethyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-methyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-ethyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-propyl-2-phenyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Ethyl propionate, 2-ethoxy-3- (4- [2- [7-butyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-phenyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-methyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-ethyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-propyl-2-benzyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-butyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-propyl-2-phenylethyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
Ethyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-phenylethyl)
-5H-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -f
Enyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-ethyl-2-methyl-5H-dibenzo]
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-propyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-phenyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-benzyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-methyl-2-ethyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-propyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-phenyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-benzyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-methyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-ethyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-phenyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-benzyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
Ethyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-methyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-ethyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-propyl-2-phenyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-butyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-phenyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-methyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-ethyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-propyl-2-benzyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-butyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
1) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-phenylethyl]
-5H-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -f
Enyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [2-methyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [2-ethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [2-propyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [2-phenyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [2-benzyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [2-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propion
Acid, 2-ethoxy-3- (4- [2- [3-methyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [3-ethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [3-propyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [3-phenyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [3-benzyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [3-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propion
Acid, 3- (4- [2- [2,8-dimethyl-5H-dibenzo [a, d] cyclohepte
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
3- (4- [2- [2,8-diethyl-5H-dibenzo [a, d] cyclohepte)
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
3- (4- [2- [2,8-dipropyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid, 3- (4- [2- [2,8-diphenyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid, 3- (4- [2- [2,8-dibenzyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid, 3- (4- [2- [2,8-diphenylethyl-5H-dibenzo [a, d] cyc]
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-pro
Pionic acid, 3- (4- [2- [2,7-dimethyl-5H-dibenzo [a, d] cyclohepte
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
3- (4- [2- [2,7-diethyl-5H-dibenzo [a, d] cyclohepte)
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
3- (4- [2- [2,7-dipropyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid, 3- (4- [2- [2,7-diphenyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid, 3- (4- [2- [2,7-dibenzyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid, 3- (4- [2- [2,7-diphenylethyl-5H-dibenzo [a, d] cyc]
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-pro
Pionic acid, 3- (4- [2- [3,7-dimethyl-5H-dibenzo [a, d] cyclohepte
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
3- (4- [2- [3,7-diethyl-5H-dibenzo [a, d] cyclohepte)
5-Nyloxy] -ethoxy] -phenyl) -2-ethoxy-propionic acid
3- (4- [2- [3,7-dipropyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid, 3- (4- [2- [3,7-diphenyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid, 3- (4- [2- [3,7-dibenzyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-propion
Acid, 3- (4- [2- [3,7-diphenylethyl-5H-dibenzo [a, d] cyc]
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-ethoxy-pro
Pionic acid, 2-ethoxy-3- (4- [2- [7-ethyl-2-methyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid, 2-ethoxy-3- (4- [2- [7-propyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-phenyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-benzyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [7-methyl-2-ethyl-5H-dibenzo)
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid, 2-ethoxy-3- (4- [2- [7-propyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-phenyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-benzyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [7-methyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-ethyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-phenyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [7-benzyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [7-methyl-2-phenyl-5H-diben
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-ethyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-propyl-2-phenyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [7-butyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-phenyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [7-methyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-ethyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-propyl-2-benzyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [7-butyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [7-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [7-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [7-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [7-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [7-phenylethyl-2-phenylethyl)
-5H-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -f
Enyl) -propionic acid, 2-ethoxy-3- (4- [2- [8-ethyl-2-methyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid, 2-ethoxy-3- (4- [2- [8-propyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-phenyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-benzyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [8-methyl-2-ethyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid, 2-ethoxy-3- (4- [2- [8-propyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-phenyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-benzyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [8-methyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-ethyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-phenyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [8-benzyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [8-methyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-ethyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-propyl-2-phenyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [8-butyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-phenyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [8-methyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-ethyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-propyl-2-benzyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-ethoxy-3- (4- [2- [8-butyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [8-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [8-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [8-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [8-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-ethoxy-3- (4- [2- [8-phenylethyl-2-phenylethyl]
-5H-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -f
Enyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-methyl-10,11-diphenyl)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (2-ethyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (2-propyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (2-phenyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (2-benzyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (2-phenylethyl-10,1)
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-methyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-ethyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-propyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-phenyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-benzyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (3-phenylethyl-10,1)
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid ethyl ester, 3- (4- [2- [2,8-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-ethoxy-propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-methyi)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-pro
Pill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-fe)
Nyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-benzyl-)
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ben)
Jill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-phenyle)
Cyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-fe)
Nylethyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester
2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-methyi)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-pro
Pill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-fe)
Nyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-benzyl-)
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ben)
Jill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-phenyle)
Cyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-fe)
Nylethyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester
2-ethoxy-3- (4- [2- [methyl- (2-methyl-10,11-diphenyl)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-ethyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-propyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-phenyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-benzyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (2-phenylethyl-10,1)
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-methyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
Cis] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-ethyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-propyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-phenyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-benzyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (3-phenylethyl-10,1)
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid, 3- (4- [2- [2,8-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,8-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,8-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,8-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,8-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,8-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,7-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,7-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,7-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,7-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,7-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid, 3- (4- [2- [2,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-ethoxy-propionic acid, 3- (4- [2- [3,7-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid, 3- (4- [2- [3,7-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-ethoxy-propionic acid, 3- (4- [2- [3,7-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid, 3- (4- [2- [3,7-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid, 3- (4- [2- [3,7-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-ethoxy-propionic acid, 3- (4- [2- [3,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-ethoxy-propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-methyi)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-pro
Pill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-fe)
Nyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-benzyl)-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ben)
Jill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-methyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-ethyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-propyl-2-phenyle)
Cyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-butyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (7-phenylethyl-2-fe)
Nylethyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-methyi)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-pro
Pill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-fe)
Nyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-benzyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ben)
Jill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-methyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-ethyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-propyl-2-phenyle)
Cyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-butyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-ethoxy-3- (4- [2- [methyl- (8-phenylethyl-2-fe)
Nylethyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2-methyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate
Ester, 2-methoxy-3- (4- [2- [2-ethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate
Esters, 2-methoxy-3- (4- [2- [2-propyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-methoxy-3- (4- [2- [2-phenyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-methoxy-3- (4- [2- [2-benzyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-methoxy-3- (4- [2- [2-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propion
Acid ethyl ester, 2-methoxy-3- (4- [2- [3-methyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate
Ester, 2-methoxy-3- (4- [2- [3-ethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -ethyl propionate
Esters, 2-methoxy-3- (4- [2- [3-propyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-methoxy-3- (4- [2- [3-phenyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-methoxy-3- (4- [2- [3-benzyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid
Ester, 2-methoxy-3- (4- [2- [3-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propion
Acid ethyl ester, 3- (4- [2- [2,8-dimethyl-5H-dibenzo [a, d] cyclohepte
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
Ethyl ester, 3- (4- [2- [2,8-diethyl-5H-dibenzo [a, d] cyclohepte
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
Ethyl ester, 3- (4- [2- [2,8-dipropyl-5H-dibenzo [a, d] cyclohep]
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid ethyl ester, 3- (4- [2- [2,8-diphenyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid ethyl ester, 3- (4- [2- [2,8-dibenzyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid ethyl ester, 3- (4- [2- [2,8-diphenylethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-pro
Pionic acid ethyl ester, 3- (4- [2- [2,7-dimethyl-5H-dibenzo [a, d] cyclohepte)
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
Ethyl ester, 3- (4- [2- [2,7-diethyl-5H-dibenzo [a, d] cyclohepte
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
Ethyl ester, 3- (4- [2- [2,7-dipropyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid ethyl ester, 3- (4- [2- [2,7-diphenyl-5H-dibenzo [a, d] cyclohep]
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid ethyl ester, 3- (4- [2- [2,7-dibenzyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid ethyl ester, 3- (4- [2- [2,7-diphenylethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-pro
Pionic acid ethyl ester, 3- (4- [2- [3,7-dimethyl-5H-dibenzo [a, d] cyclohepte)
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
Ethyl ester, 3- (4- [2- [3,7-diethyl-5H-dibenzo [a, d] cyclohepte
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
Ethyl ester, 3- (4- [2- [3,7-dipropyl-5H-dibenzo [a, d] cyclohep]
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid ethyl ester, 3- (4- [2- [3,7-diphenyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid ethyl ester, 3- (4- [2- [3,7-dibenzyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid ethyl ester, 3- (4- [2- [3,7-diphenylethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-pro
Pionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-ethyl-2-methyl-5H-dibenzo)
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-propyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-phenyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-benzyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-methyl-2-ethyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-propyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-phenyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-benzyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-methyl-2-propyl-5H-diben
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-ethyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-phenyl-2-propyl-5H-dibe
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-benzyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-methyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-ethyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-propyl-2-phenyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-butyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-phenylethyl-2-phenyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-methyl-2-benzyl-5H-diben
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-ethyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-propyl-2-benzyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-butyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [7-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [7-phenylethyl-2-phenylethyl)
-5H-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -f
Enyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-ethyl-2-methyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-propyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-phenyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-benzyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-methyl-2-ethyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-propyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-phenyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-benzyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-methyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-ethyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-phenyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-benzyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-methyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-ethyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-propyl-2-phenyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-butyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-phenylethyl-2-phenyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-methyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-ethyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-propyl-2-benzyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-butyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ethyl ropionate, 2-methoxy-3- (4- [2- [8-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid ethyl ester, 2-methoxy-3- (4- [2- [8-phenylethyl-2-phenylethyl]
-5H-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -f
Enyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [2-methyl-5H-dibenzo [a, d] cyclo)
Lohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2-ethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2-propyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2-phenyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2-benzyl-5H-dibenzo [a, d] cy]
Chlohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [2-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propion
Acid, 2-methoxy-3- (4- [2- [3-methyl-5H-dibenzo [a, d] cyclo)
Lohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [3-ethyl-5H-dibenzo [a, d] cyclo)
Rohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [3-propyl-5H-dibenzo [a, d] cy]
Chlohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [3-phenyl-5H-dibenzo [a, d] cy]
Clohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [3-benzyl-5H-dibenzo [a, d] cy]
Chlohepten-5-yloxy] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [3-phenylethyl-5H-dibenzo [a,
d] Cyclohepten-5-yloxy] -ethoxy] -phenyl) -propion
Acid, 3- (4- [2- [2,8-dimethyl-5H-dibenzo [a, d] cyclohepte
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
3- (4- [2- [2,8-diethyl-5H-dibenzo [a, d] cyclohepte)
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
3- (4- [2- [2,8-dipropyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid, 3- (4- [2- [2,8-diphenyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid, 3- (4- [2- [2,8-dibenzyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid, 3- (4- [2- [2,8-diphenylethyl-5H-dibenzo [a, d] cyc]
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-pro
Pionic acid, 3- (4- [2- [2,7-dimethyl-5H-dibenzo [a, d] cyclohepte
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
3- (4- [2- [2,7-diethyl-5H-dibenzo [a, d] cyclohepte)
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
3- (4- [2- [2,7-dipropyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid, 3- (4- [2- [2,7-diphenyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid, 3- (4- [2- [2,7-dibenzyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid, 3- (4- [2- [2,7-diphenylethyl-5H-dibenzo [a, d] cyc]
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-pro
Pionic acid, 3- (4- [2- [3,7-dimethyl-5H-dibenzo [a, d] cyclohepte
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
3- (4- [2- [3,7-diethyl-5H-dibenzo [a, d] cyclohepte)
N-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propionic acid
3- (4- [2- [3,7-dipropyl-5H-dibenzo [a, d] cyclohep)
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid, 3- (4- [2- [3,7-diphenyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid, 3- (4- [2- [3,7-dibenzyl-5H-dibenzo [a, d] cyclohep
Ten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-propion
Acid, 3- (4- [2- [3,7-diphenylethyl-5H-dibenzo [a, d] cyc]
Rohepten-5-yloxy] -ethoxy] -phenyl) -2-methoxy-pro
Pionic acid, 2-methoxy-3- (4- [2- [7-ethyl-2-methyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid, 2-methoxy-3- (4- [2- [7-propyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-phenyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-benzyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [7-methyl-2-ethyl-5H-dibenzo)
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid, 2-methoxy-3- (4- [2- [7-propyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-phenyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-benzyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [7-methyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-ethyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-phenyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [7-benzyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [7-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [7-methyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-ethyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-ethoxy-3- (4- [2- [7-propyl-2-phenyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [7-butyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-phenylethyl-2-phenyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [7-methyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-ethyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-propyl-2-benzyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [7-butyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [7-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [7-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [7-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [7-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
L) -propionic acid, 2-methoxy-3- (4- [2- [7-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [7-phenylethyl-2-phenylethyl)
-5H-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -f
Enyl) -propionic acid, 2-methoxy-3- (4- [2- [8-ethyl-2-methyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid, 2-methoxy-3- (4- [2- [8-propyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-phenyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-benzyl-2-methyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-phenylethyl-2-methyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [8-methyl-2-ethyl-5H-dibenzo
[A, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -pro
Pionic acid, 2-methoxy-3- (4- [2- [8-propyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-phenyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-benzyl-2-ethyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-phenylethyl-2-ethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [8-methyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-ethyl-2-propyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-phenyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [8-benzyl-2-propyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [8-phenylethyl-2-propyl-5H
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [8-methyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-ethyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-propyl-2-phenyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [8-butyl-2-phenyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-phenylethyl-2-phenyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [8-methyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-ethyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-propyl-2-benzyl-5H-dibe]
Nzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl)-
Propionic acid, 2-methoxy-3- (4- [2- [8-butyl-2-benzyl-5H-diben]
Zo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl) -p
Ropionic acid, 2-methoxy-3- (4- [2- [8-phenylethyl-2-benzyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [8-methyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [8-ethyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [8-propyl-2-phenylethyl-5H]
-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [8-butyl-2-phenylethyl-5H-
Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -phenyl
) -Propionic acid, 2-methoxy-3- (4- [2- [8-phenylethyl-2-phenylethyl]
-5H-Dibenzo [a, d] cyclohepten-5-yloxy] -ethoxy] -f
Enyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-methyl-10,11-diphenyl)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (2-ethyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (2-propyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (2-phenyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (2-benzyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (2-phenylethyl-10,1)
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-methyl-10,11-diphenyl)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-ethyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
[S] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-propyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-phenyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-benzyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (3-phenylethyl-10,1)
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid ethyl ester, 3- (4- [2- [2,8-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,8-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl-phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [2,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid ethyl ester, 3- (4- [2- [3,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-methoxy-propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-methyi)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-pro
Pill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-fe)
Nyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-benzyl)-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ben)
Jill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-phenyle)
Cyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-fe)
Nylethyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester
2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-methyi)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-pro
Pill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-fe)
Nyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-benzyl)-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ben)
Jill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
L) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-phenyle)
Cyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-fe)
Nylethyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid ethyl ester
2-methoxy-3- (4- [2- [methyl- (2-methyl-10,11-diphenyl)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
Cis] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-ethyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
Cis] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-propyl-10,11-di)
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-phenyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-benzyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (2-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-methyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
Cis] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-ethyl-10,11-dihi)
Dro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -ethoxy
Cis] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-propyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-phenyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-benzyl-10,11-di
Hydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino] -etho
Xy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (3-phenylethyl-10,1
1-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amino]
-Ethoxy] -phenyl) -propionic acid, 3- (4- [2- [2,8-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nil) -2-methoxy-propionic acid, 3- (4- [2- [2,8-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid, 3- (4- [2- [2,8-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid, 3- (4- [2- [2,8-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid, 3- (4- [2- [2,8-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid, 3- (4- [2- [2,8-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-methoxy-propionic acid, 3- (4- [2- [2,7-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nil) -2-methoxy-propionic acid, 3- (4- [2- [2,7-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid, 3- (4- [2- [2,7-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid, 3- (4- [2- [2,7-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid, 3- (4- [2- [2,7-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid, 3- (4- [2- [2,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-methoxy-propionic acid, 3- (4- [2- [3,7-dimethyl-10,11-dihydro-5H-dibenzo]
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid, 3- (4- [2- [3,7-diethyl-10,11-dihydro-5H-dibenzo)
[A, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -fe
Nyl) -2-methoxy-propionic acid, 3- (4- [2- [3,7-dipropyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid, 3- (4- [2- [3,7-diphenyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid, 3- (4- [2- [3,7-dibenzyl-10,11-dihydro-5H-diben]
Zo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy] -f
Enyl) -2-methoxy-propionic acid, 3- (4- [2- [3,7-diphenylethyl-10,11-dihydro-5H-
Dibenzo [a, d] cyclohepten-5-yl) -methyl-amino] -ethoxy
] -Phenyl) -2-methoxy-propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-methyi)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-pro
Pill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid ethyl ester, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-fe)
Nyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-benzyl)-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-ben)
Jill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-methyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-ethyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-propyl-2-phenyle)
Cyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-butyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (7-phenylethyl-2-fe)
Nylethyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-methyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-methyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-methyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-ethyl-10)
, 11-Dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -amido
No] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-ethyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-propyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-benzyl-2-propyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-pro
Pill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-phenyl-
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-phenyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-fe)
Nyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-benzyl-)
10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl)-
Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-benzyl-1)
0,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -a
Mino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-ben)
Jill-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-methyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-ethyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-propyl-2-phenyle)
Cyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-5-y
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-butyl-2-phenylethyl)
-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl
) -Amino] -ethoxy] -phenyl) -propionic acid, 2-methoxy-3- (4- [2- [methyl- (8-phenylethyl-2-fe)
Nylethyl-10,11-dihydro-5H-dibenzo [a, d] cycloheptene-
5-yl) -amino] -ethoxy] -phenyl) -propionic acid, 3- (4- [2- [5H-dibenzo [a, d] cyclohepten-5-yloxy)
] -Ethoxy] -phenyl) -2-ethoxy-propionic acid ethyl ester, 3- (4- [2- (6,11-dihydrobenzo [b, e] thiepin-11-yl)
Ethyl oxy) -ethoxy] -phenyl) -2-ethoxy-propionate
3- (4- [2- (6,11-dihydrobenzo [b, e] thiepin-11-yl)
Oxy) -ethoxy] -phenyl) -2-ethoxy-propionic acid, 3- (4- [2- (6,11-dihydrobenzo [b, e] oxypin-11-i)
2- (oxy) -ethoxy] -phenyl) -2-ethoxy-propionate
Ter, 3- (4- [2- (2,10-dichloro-12H-5,7-dioxa-dibenzo)
[A, d] cycloocten-12-yloxy) -ethoxy] -phenyl) -2
-Ethoxy-propionic acid ethyl ester, 3- (4- [2- (2,10-dichloro-12H-5,7-dioxa-dibenzo)
[A, d] cycloocten-12-yloxy) -ethoxy] -phenyl) -2
-Ethoxy-propionic acid, 2-ethoxy-3- (4- [2- (2-methyl-9,10-dihydro-4H-1)
-Oxa-3-aza-benzo [f] azulen-4-yloxy) -ethoxy]-
Phenyl) -propionic acid ethyl ester, 3- (4- [2- (10,11-dihydro-5H-dibenzo [a, d] cyclo
Puten-5-yloxy) -ethoxy] -phenyl) -2-ethoxy-propane
Acid ethyl ester, 3- (4- [2- (10,11-dihydro-5H-dibenzo [a, d] cyclo
Puten-5-yloxy) -ethoxy] -phenyl) -2-ethoxy-propane
Acid, 3- (4- [2-([10,11-dihydro-5H-dibenzo [a, d] cyclo
Hepten-5-yl] -methyl-amino) -ethoxy] -phenyl) -2-eth
Xy-propanoic acid ethyl ester, 3- (4- [2-([10,11-dihydro-5H-dibenzo [a, d] cyclo
Hepten-5-yl] -methyl-amino) -ethoxy] -phenyl) -2-eth
Xy-propanoic acid, 3- {4- [2- (6,11-dihydro-dibenzo [b, e] oxepin-11
-Ylsulfanyl) -ethoxy] -phenyl} -2-ethoxy-propionic acid
2-ethoxy-3- {4- [2- (5-methyl-6-oxo-6,11-dihi
Dro-5H-dibenzo [b, e] azepin-11-yloxy) -ethoxy] -f
Phenyl} -propionic acid, 3- {4- [2- (4,9-dihydro-1,10-dithia-benzo [f] azure]
4-Nyloxy) -ethoxy] -phenyl} -2-ethoxy-propionic acid
3- {4- [2- (12H-5,7-dioxa-dibenzo [a, d] cyclooctane]
Ten-12-yloxy) -ethoxy] -phenyl {-2-ethoxy-propio
The compound according to claim 1, which is an acid or a pharmaceutically acceptable salt thereof. 57. 3- {4- [2- (10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yloxy) -ethoxy] -phenyl} -2-
Ethoxypropionic acid, 3- {4- [2- (6,11-dihydro-dibenzo [b, e] oxepin-11
-Ylsulfanyl) -ethoxy] -phenyl} -2-ethoxy-propionic acid, 3- (4- {2-[(10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5-yl) -methyl -Amino] -ethoxy} -phenyl) -2-ethoxy-propionic acid, 2-ethoxy-3- {4- [2- (5-methyl-6-oxo-6,11-dihydro-5H-dibenzo [b, e] azepine-11-yloxy) -ethoxy] -phenyl} -propionic acid, 3- {4- [2- (4,9-dihydro-1,10-dithia-benzo [f] azulen-4-yloxy)- Ethoxy] -phenyl {-2-ethoxy-propionic acid, 3- {4- [2- (12H-5,7-dioxa-dibenzo [a, d] cycloocten-12-yloxy) -ethoxy] -phenyl}- 2- Butoxy - propionic acid, or a pharmaceutically acceptable compound according to claim 1 a salt thereof. 58. A pharmaceutical composition comprising as an active ingredient a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. 59. The method of claim 1, wherein the amount is from about 0.05 to about 100 mg, preferably from about 0.1 to about 50 mg.
59. The composition of claim 58, wherein said composition is in a unit dosage form comprising a compound of any one of claims 57 or a pharmaceutically acceptable salt thereof. 60. A nuclear receptor comprising as active ingredient a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. In particular, a pharmaceutical composition useful in the treatment and / or prevention of situations mediated by peroxisome proliferator-activated receptors (PPAR). 61. A method for treating diabetes and / or diabetes comprising as an active ingredient a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Or a pharmaceutical composition useful in treating and / or preventing obesity. 62. Diabetes and / or comprising as an active ingredient a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Or a composition for obesity. 63. The method of claim 58 for oral, nasal, transdermal, pulmonary or parenteral administration.
63. The pharmaceutical composition according to any one of -62. 64. A method for treating a chronic disease, comprising an effective amount of a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof, or 58.
64. A method comprising administering to the subject in need thereof a composition according to any of the preceding claims. 65. Nuclear receptors, in particular peroxisome proliferator-activated receptors (
A method for the treatment and / or prevention of a condition mediated by PPAR), wherein said compound or pharmaceutically acceptable salt thereof according to any one of claims 1 to 57, or a pharmaceutically acceptable salt thereof. 64. A method comprising administering to the subject in need thereof a composition according to any of claims 58-63. 66. A method for treating and / or preventing diabetes and / or obesity, comprising an effective amount of a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof. Or administering a composition according to any one of claims 58 to 63 to a subject in need thereof. 67. The effective amount of a compound according to any one of claims 1 to 57, or a pharmaceutically acceptable salt or ester thereof, of from about 0.05 to about 100 mg / day, preferably from about 0.1 to about 50 mg. 67. The method of any of claims 64-66, wherein the range is / day. 68. Use of a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof for the preparation of a medicament. 69. Nuclear receptors, in particular peroxisome proliferator-activated receptors (
58. Use of a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof for the preparation of a medicament useful in the treatment and / or prevention of conditions mediated by PPAR). 70. Use of a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment and / or prevention of diabetes and / or obesity. use. 71. Use of a compound according to any one of claims 1 to 57 or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment and / or prevention of diabetes and obesity.