JP2002248158A - Medical container stored with article and container suitable for the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a container easy to operate in mixing an infusion solution containing an amino acid, sugar, fat and/or electrolyte with a plurality of vitamins for compounding in this infusion solution, capable of stably preserving and maintaining the plurality of vitamins for a long period of time, capable of decreasing as much as possible an unnecessary components except medicines necessary for a living body, and easy to manufacture. SOLUTION: A synthetic resin container for the infusion solution has a discharge port 9 in its lower end 7 and stores the infusion solution containing the amino acid, sugar, fat, electrolyte, etc., in storing chambers 3, 5, and has a plurality of partitioned chambers 15a... liquid-tightly partitioned from the storing chambers 3, 5 by isolated parts 11a... formed at least in the up and down direction and by partitioned parts 13a continuously connected from the isolated parts 11a... and connectably formed at least in the breath direction. The plurality of vitamins are stored in the plurality of partitioned chambers 15... so as to isolate at least one part of vitamins differing in property from other vitamins.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a container containing an infusion solution containing amino acids, sugars, fats, and / or electrolytes, and more particularly to a container for stably storing vitamins to be blended in the infusion solution. Medical containers with
The present invention relates to a multi-chamber container that can be suitably used for this medical container.

[0002]

2. Description of the Related Art Infusions containing amino acids, sugars, fats, and / or electrolytes are frequently used. When this infusion is administered to a patient for a long period of time, a small amount of vitamin is mixed with the infusion and administered. In particular, mixing vitamin B1 consumed by sugar metabolism or the like is indispensable for long-term administration. Vitamin is an unstable substance, so if it is mixed in the infusion at the time of manufacture, it will be degraded over time due to heat, light, the action of other components in the infusion during the sterilization process and storage period. It has been known. Therefore, conventionally, the drug was mixed in the infusion container using a syringe or the like at the time of administration. However, since the amount of vitamins to be mixed is extremely large and very small, and it is necessary to maintain sterility, the mixing operation at the time of administration is troublesome. Therefore, in recent years, various infusions in which a vitamin is previously blended at the time of production by selecting a combination that can ensure the stability of the vitamin have been proposed.

[0003] However, in such an infusion containing vitamins, more than 10 kinds of vitamins are contained in the infusion component which is divided into two or three chambers, so that the stability of all of the formulated vitamins is reduced. It was difficult to secure. Vitamin, especially in the case of a liquid containing vitamin, the stability is easily changed by pH and coexisting substances,
Therefore, in infusions containing many vitamins, taking into account the interaction between vitamins, the interaction between other components such as electrolytes and various additives and vitamins, etc. , A particular combination was selected. For example, in Japanese Patent Application Laid-Open No. Hei 10-203959, vitamin B1, B12, A, D,
E and K are dissolved to adjust the pH to 3.5 to 4.5, and vitamin B2, C, and folic acid are dissolved in the amino acid-containing solution to adjust the pH to 5.0 to 7.0. are doing. It is stated that vitamin B6, biotin, nicotinamide and panthenol may be dissolved in either liquid. Here, stabilization is attempted in consideration of many interactions. However, when this vitamin-containing infusion is examined from the stable pH range of the simple preparation of each vitamin, the stable pH of the simple preparation of vitamin E dissolved in the sugar-containing solution is, for example, 5.0 to 7.0.
About 0, vitamin K is, for example, about 6.0 to 8.0, and the pH of the solution is not in a stable range. Further, the stable pH of the simple preparation of folic acid dissolved in the amino acid-containing liquid is 8.0 to 8.0.
It is about 11.0, and the pH of the solution is not within a stable range. Furthermore, the stable pH of vitamin B6, which is considered to be soluble in either solution, is set to 3.0 to 5.0 in the official publication (Japanese Pharmacopoeia) and the like, but is actually 3.0 to 5.0.
It is about 4.0, and the pH of any liquid is not in a stable range. In addition, in an actual container, the pH of the sugar-containing liquid and the amino acid-containing liquid has a specific value within the above range, so that vitamins whose pH values are not included in the stable pH range further increase. Therefore, in such an infusion, if the balance with the coexisting substance is lost, it is difficult to maintain many vitamins sufficiently stable. Many other vitamin-containing infusions have been proposed (Japanese Patent Application Laid-Open No. 6-209979,
This is the same as in JP-A-11-158061.

In conventional infusions in which vitamins are dissolved and stored, the pH of the infusion is adjusted to a predetermined value in order to increase the stability of many vitamins as much as possible. This pH adjustment is performed by adding a pH adjuster such as an organic acid such as acetic acid or citric acid, or an inorganic acid to the infusion solution. However, this infusion is significantly higher than the amount of dissolved vitamins, and significantly higher pH
Although adjusting agents are used, such pH adjusting agents are often unnecessary for the patient to be administered. Therefore, as a result, there is a problem in that administration of this infusion causes a large amount of unnecessary components to be administered to the living body. Further, such a thing is not limited to the pH adjuster, and the same applies to the amount of various agents such as a solubilizer, a buffer, and an antioxidant for fat-soluble vitamins.

[0005]

SUMMARY OF THE INVENTION The present invention solves the above-mentioned conventional problems by mixing an infusion solution containing amino acids, sugars, fats, and / or electrolytes with a plurality of vitamins to be incorporated into the infusion solution. It is easy to operate, can stably maintain the plurality of vitamins at the time of production and storage, and can minimize unnecessary components other than drugs essential for living organisms as much as possible, and is easy to produce. And a multi-chamber container suitable for the same.

[0006]

Means for Solving the Problems In a conventional medical container,
In order to accommodate a large amount of infusions and various kinds of small amounts of vitamins in a single container and improve usability, it was considered essential to stabilize by mixing vitamins during infusions. Only the formation of a stable system that holds only in various combinations and ratios has been performed. However, it is necessary to balance the coexistence of infusions and vitamins in the same solution and to adjust the fluidity of the infusions to a physiologically acceptable value, so that all vitamins are stored in a sufficiently stable manner. In addition, there is a problem that the amount of components unnecessary for the living body is increased. Thus, the present inventors
As a result of diligent research, we gained a new idea that improving usability and stably accommodating vitamins can be distinguished from each other.
The container of the present invention, which is contained in one container but is not allowed to coexist, that is, it is not intended to stabilize by storing various kinds of trace amounts of vitamins and infusions in separate containers, and also to store various kinds of trace amounts of vitamins. This resulted in the completion of a container that was not dissolved in an infusion solution to improve usability.

[0007] The medical container of the present invention is a container in which an infusion solution containing one or more selected from the group consisting of amino acids, sugars, fats, and electrolytes is contained in a container.
The storage room is provided with a partition portion that can communicate with the storage room, and the storage room is partitioned in a liquid-tight manner, and has a plurality of compartments smaller than the storage room, and the plurality of vitamins are at least partially contained in the plurality of compartments. It is characterized in that vitamins and other vitamins are contained so as to be isolated.

According to the present invention, a plurality of compartments, which are liquid-tightly partitioned from the accommodation room and are smaller than the accommodation room,
Multiple vitamins with different properties are stored so that at least a part of vitamins and other vitamins are isolated, so that vitamins stored in multiple compartments can be stored while being separated from infusion components. Further, the vitamins in each compartment can be accommodated in a state separated from the vitamins in the other compartments. Therefore, the optimum conditions for the vitamins contained in each compartment can be set for each compartment, and the vitamins can be prevented from changing over time during production and storage. In addition, since a plurality of compartments are provided with partitions that can communicate with the storage room, even if vitamins are isolated and stored in a plurality of compartments, the vitamins can be easily used by connecting the compartments when in use. Can be used in combination with an infusion, and the infusion and vitamins are not exposed to the outside air during this mixing. Moreover, it is partitioned liquid-tight from the accommodation room,
In addition, since vitamins are stored in a plurality of compartments smaller than the accommodation room, each vitamin can be accommodated in an arbitrary dosage form. The volume can be any volume, and the vitamin concentration in each compartment can be set higher than when vitamins are mixed into the infusion. In general, it is known that the higher the solute concentration, the more difficult it is to decompose the solution when heated.However, if the vitamin concentration is increased in this way, the decomposition of the vitamin during heating such as sterilization can be suppressed, and the Heat sterilization can be performed while each vitamin is contained. In addition, many vitamins may add stabilizers such as pH adjusters to ensure vitamin stability, solubilizers to solubilize fat-soluble vitamins, buffers, antioxidants, etc. However, such a combination is often an unnecessary component for the patient, and it is preferable to reduce the amount as much as possible. If the vitamin is dissolved or dispersed in the container of the present invention and accommodated in the compartment, even if the stabilizer is added so as to have a sufficient concentration, the amount of liquid in the compartment is smaller than that of the infusion, and is added to the infusion. The amount of the various stabilizers as described above can be significantly reduced as compared with the case of performing the method. In addition, when a vitamin having a property that is easily adsorbed on the container wall is stored in the compartment, the area of the inner wall surface of the compartment is smaller than that of the accommodation room because the plurality of compartments are smaller than the accommodation room. The amount of adsorbed vitamins on the container wall can be reduced as compared with the case where the water is stored.

In the infusion container of the present invention, if a water-soluble vitamin and a fat-soluble vitamin are separately housed in a plurality of compartments, the interface between the water-soluble vitamin and the fat-soluble vitamin in a case where the fat-soluble vitamin is dispersed in a drug solution is housed. Even if a sufficient amount of activator and stabilizer is used for fat-soluble vitamins, since the compartment is smaller than the storage room, compared to those which are dispersed in a large amount of liquid such as infusion, surfactants And the amount of stabilizer used can be reduced. In addition, since it is isolated from water-soluble vitamins, the effect of modifying the interface of the solubilizer attached to fat-soluble vitamins is not impaired by ions generated from the water-soluble vitamins, solubilizing or dispersing systems. It is easy to keep stable. Furthermore, some fat-soluble vitamins have a property that they are easily adsorbed to the container wall of the storage chamber. However, if they are stored in the compartment, the area of the inner wall surface of the compartment is smaller than that of the storage chamber. It is remarkable to reduce the amount of vitamin adsorbed to the skin. Moreover, since many fat-soluble vitamins are liable to be deteriorated by light, it is easy to perform a treatment such as shading by accommodating them in the same compartment.

Further, according to the present invention, when a plurality of compartments contain at least a part of a plurality of vitamins having a different stable pH range in a single preparation and are separated from each other, the pH in each compartment is stored in the compartments. It can be set to the stable pH range of the given vitamin, and the stability of the vitamin in each compartment can be ensured. When the vitamin is used as an aqueous vitamin-containing liquid and the vitamin-containing liquids having different pHs are accommodated in different compartments, the vitamin-containing liquid is an aqueous liquid, so that it is easy to mix with an infusion solution, and the liquid is used until mixing. Can be stored in a stable pH range. Further, when the pH of the vitamin-containing liquid stored in at least some of the compartments is different from the pH of the infusion in the storage chamber, the p
If H is within the stable pH range of any vitamin, stability can be ensured even when the vitamin is stored in a mixed state with an infusion solution, so that the number of compartments can be reduced.

In the medical container with contents of the present invention, a vitamin-containing liquid containing vitamin B1 is stored in any one of the plurality of compartments, and p
When H is adjusted to be lower than the pH of the liquid stored in the other compartments and storage chambers, vitamin B1 essential for infusion containing sugar or fat can be reliably and stably stored,
Long-term administration can suppress acidosis in patients. In addition, since vitamin B1 is one of the lowest stable pH among vitamins administered to an infusion solution, it is not necessary to excessively lower the pH of the infusion solution, especially the sugar-containing solution, and the pH adjustment of the sugar-containing solution is prevented. The amount of agent can be reduced. Furthermore, a vitamin-containing liquid containing folic acid is contained in any one of the plurality of compartments, and p
If H is adjusted to be higher than the pH of the liquid stored in the other compartments and storage chambers, the stable pH range of folate is higher than other vitamins and infusions. This is preferable because it is not necessary to set it unnecessarily high. In addition, when a vitamin-containing liquid containing vitamin D is contained in any one of the plurality of compartments, the vitamin D is easily adsorbed on the inner wall surface of the synthetic resin container. By storing in a compartment having a small amount of vitamin D, reduction due to adsorption of vitamin D during storage can be suppressed. Further, when a vitamin-containing liquid containing vitamin C is contained in any one of the plurality of compartments, vitamin C has a strong reducing property, and is likely to interact with other components. When subjected to heat sterilization, it is preferable to coexist with an antioxidant.However, since the compartment is smaller than the accommodation room, the concentration of the antioxidant is adjusted to a level sufficient to obtain a sufficient antioxidant effect. Even so, the amount of use can be significantly reduced as compared with the case where it is accommodated in the accommodation room.

A multi-chamber container particularly suitable for the medical container with contents of the present invention is a multi-chamber container made of a synthetic resin having a sealed housing chamber, and a plurality of isolated containers each formed of a non-peelable strong seal. Section and a partition section made of a peelable weak seal continuous from the isolation section, the compartment is liquid-tightly partitioned from the storage chamber, and has a plurality of compartments smaller than the storage chamber, and at least a plurality of the isolation sections. A part thereof is oriented to one side, and the partition part is arranged on one side of the part.

[0013] In such a multi-chamber container of the present invention, the container is liquid-tightly partitioned from the storage chamber by a plurality of separating portions formed of a non-peelable strong seal and a partition portion formed of a peelable weak seal continuous from the separating portion. A plurality of compartments, and the plurality of compartments are smaller than the accommodation room, so that it is possible to accommodate each of the plurality of other accommodation items in a smaller amount than the accommodation item of the accommodation room in an isolated state. It is possible to easily set the properties of the articles to be accommodated in the plurality of compartments to different conditions, and to easily mix the components that easily change in quality and the articles that have different stable accommodation conditions when mixed. Further, by merely peeling off the weak seal of the partition, each compartment and the accommodation chamber can be communicated, and it is possible to easily mix the respective accommodations accommodated under different conditions without exposing them to the outside air. . Therefore, it can be suitably used as a container for accommodating a large number of contents that are required to be stored under different storage conditions and are mixed at the time of use, such as the above-mentioned infusion and a large number of trace amounts of vitamins. In addition, since at least a part of the non-peeling isolation part is oriented to one side and the partition part is arranged on one side, each compartment communicates with the other chamber only by preventing separation of the partition part on one side. Even if a large number of compartments are formed, it is easy to reliably maintain each compartment in a liquid-tight manner, and since the partitions are on one side, all the partitions can be peeled off from one side, It is easy to make many compartments communicate with the accommodation rooms.

Further, since the separating portion is formed of a strong seal that cannot be peeled off and the partition portion is formed of a weak seal that can be peeled off, the compartment can be manufactured only by bringing the inner wall surfaces of the container into contact with each other and welding.
A large number of compartments can be easily formed, the manufacture of the container is easy, and at the same time, all the compartments and the accommodation chambers can be communicated only by peeling off the weak seal of the partition. The mixing operation of the contents can be performed at once, and the mixing operation is easy. If a large number of compartments are formed using only weak seals, some weak seals will be destroyed if an unexpected force is applied from the outside, and this will trigger communication between many compartments and other rooms. However, by making the isolation part a strong seal, the weakly sealed part of the compartment can be reduced, and if the liquid tightness of the partition is secured during storage, the liquid tightness of the compartment is improved. Can be preserved and stability during storage is increased. Furthermore, since the plurality of compartments are smaller than the storage chambers, the inner surface area is small, so that even if a storage object that is easily adsorbed on the container wall is stored, the adsorption is small. The surface is easy to confirm and easy to manufacture.

In the medical container according to the present invention, if a discharge port is provided at one end, the partition of each compartment is arranged on the discharge port side. When the contents are discharged from the discharge port by communicating with each other, the communicating portion between each compartment and the storage chamber can be oriented to the discharge port side, the contents are easily discharged from the compartment, and the usability is good. . In addition, when the volume of the compartment is 1/10 or less of the volume of the storage room, the size of the compartment is significantly smaller than that of the storage room, and the small amount of the stored material can be stably stored together with the small amount of the storage material in the compartment. When accommodating another coexisting substance essential for maintenance, the amount of the coexisting substance used can be reduced as compared with the case where the coexisting substance is stably maintained by accommodating a small amount of accommodation in the accommodation chamber. Further, when a plurality of compartments are arranged adjacent to each other via the isolation portion, the plurality of compartments can be formed with a small number of isolation portions, and the partition portions can be easily formed collectively. Because it can be arranged, it is easy to fill when filling multiple compartments into multiple compartments,
For example, if a plurality of filling needles are used, another compartment can be filled at the same time, which facilitates production. In addition, when the partitioning portion is continuous between both side portions of the container, the partitioning portion can be formed at a time when forming a plurality of compartments, thereby facilitating manufacture, and by folding the container at the partitioning portion. Since the compartments can be reliably maintained in a liquid-tight state with the storage chambers, the partitions are not destroyed by external pressure during storage, and the storage stability can be improved. At this time, since the separating part is a strong seal that cannot be peeled off, it does not peel off due to external pressure, and while the container is folded and maintained in the horizontal direction at the partitioning part, the compartment is separated from other compartments and storage chambers. There is no danger of communication, and the compartment can be reliably maintained in a liquid-tight state. Furthermore, if the upper end of the infusion container is sealed by a non-peelable strong seal and the upper end of the compartment is sealed by the strong seal, the sealing operation of the compartment and the sealing operation of the container can be performed simultaneously during manufacturing. Made and easy to manufacture. On the other hand, when the both ends of the compartment are sealed by a partition made of a peelable weak seal, when the compartments are communicated to mix the contents of each room, a large amount of the contents of the storage room is mixed. Is easy to flow in the narrow compartment, and the mixing operation is easy. In addition, when the accommodation room has a first accommodation room and a second accommodation room partitioned by an accommodating accommodation room partition portion, the first and second accommodation rooms are mixed and manufactured or stored, respectively. To prevent deterioration of quality, accommodate multiple containers that react and cause deterioration or discoloration, such as amino acid-containing solution and sugar-containing solution that cause Maillard reaction. And mixing operation is easy at the time of use. Further, when the partition and the storage chamber partition are formed continuously through both sides, by bending the container at the partition,
The storage stability of the compartment and the storage room can be secured at the same time.

In the present invention, the medical container has a first divided container and a second divided container, the first divided container includes the plurality of compartments, and the first divided container has a plurality of compartments. A second partition container having a first partition portion that liquid-tightly and releasably partitions one end side of the container, and a first aseptic connection portion formed at one end side from the first partition portion; A second partition portion provided with the storage chamber and partitioning one end of the second divided container in a liquid-tight and peelable manner, and a second partition formed on the one end side of the second partition container. The first divided container and the second divided container are joined by liquid-tightly connecting the first aseptic joint and the second aseptic joint. When you are
The first container and the second container can be manufactured separately, for example, the first container and the second container are sterilized separately, and then the two containers are joined together. In this case, since the first and second sterile connecting portions are connected to each other, not to the partition portions, it is easy to ensure the sterility of the connecting portion during the manufacturing process. In particular, when the first and second containers are connected from the outside by the joining member, there is no need for assembling the sterile connection portions with each other, and the connection between the two containers is easy.

[0017]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described with reference to the embodiments of the drawings. FIG. 1 shows a multi-chamber container as a medical container according to an embodiment of the present invention, wherein (a) is a front view and (b).
Is a vertical cross-sectional view, and (c) is a horizontal cross-sectional view. In FIG. 1, reference numeral 1 denotes a container body of an infusion container formed to be flexible using synthetic resin, and storage chambers 3 and 5 which are divided in a liquid-tight manner by storage chamber partition portions 13a which can communicate with each other are formed. ing. A discharge port 9 is provided at the lower end 7, and a co-injection port 10 is provided at the upper end 8 as necessary. The container main body 1 includes a plurality of separating portions 11a, 11b, 11c,.
1a, 11b, 11c,... Communicable partitions 13b, 13c, 13d.
..Compartment rooms 15a, 15b, and 15c divided by
Are provided. Here, the isolation units 11a, 11
are oriented to the discharge port 9 side, and the partitions 13b, 13c, 13d.
1b, 11c,... Are disposed on the discharge port 9 side. .. Are arranged adjacent to each other via the isolation portions 11b, 11c,. They are located adjacent to each other. Compartments 15a, 15
.., 15c... are smaller than the storage chambers 3, 5 and preferably have a volume of 1/10 or less. Also, the compartments 15a, 1
.. 5b, 15c...
Here, it is arranged on the upper end 8 side, and all the compartments 15a, 1
5b, 15c... Are other compartments 15a, 15b, 15
c and the chambers 3 and 5 are liquid-tightly partitioned. In the drawing, the numbers of the compartments 15a, 15b, 15c,... Are shown in a simplified manner and the width is enlarged.

The communicating chamber partitioning section 13a and the partitioning sections 13b, 13c, 13d,. It is linearly continuous between the portions 17a and 17b. On the other hand, the isolation units 11a, 11b, 11c,.
Is made of a strong seal formed in such a manner that the inner wall surface is brought into contact with and sufficiently welded so that the inner wall surface cannot be peeled off.
a and the partitions 13b, 13c, 13d,... In addition, the upper end 8 and the lower end 7 of the infusion container 1
Are sealed by strong seals 19, 21 which cannot be peeled off, and the compartments 15a, 15
The upper ends 16a, 16b, 16c,.
Is sealed. In addition, the front and back wall surfaces of the side portions 17a and 17b are continuous, but a strong seal that cannot be peeled off may be applied as necessary.

In this embodiment, in the container body 1 thus configured, the storage chambers 3 and 5 contain amino acids, sugars,
An infusion solution containing one or more of fat and electrolyte is appropriately accommodated. Here, the accommodation room 3 accommodates an amino acid, or an amino acid and electrolyte containing solution, and the accommodation room 5 contains sugar, sugar, or sugar. Electrolyte-containing liquids are respectively stored. On the other hand, a plurality of compartments 15a, 15b, 15c,.
-Some of the compartments contain at least two or more vitamins separately so as to sequester at least some of the vitamins from other vitamins, and each compartment 15a, 15
The inside of b, 15c,... are set to different conditions such as pH and liquid property, and are set to different conditions such as pH and liquid property different from those of the storage chambers 3 and 5, respectively. If it is not necessary to adjust the fluidity of the infusion for the purpose of accommodating vitamins, a part of other vitamins may be accommodated in the accommodation chambers 3 and 5 in this embodiment. Vitamins are in compartments 15a, 15b, 15
c ... may be stored in the form of powder or the like, but vitamins are stored as aqueous vitamin-containing liquids to facilitate mixing. In the case of fat-soluble vitamins such as vitamins A, D, E, K, etc., the vitamin-containing liquids are dispersed in an aqueous medium using a solubilizing agent, such as a surfactant, to obtain vitamin B1, B2, B6. , B12, C, nicotinic acid, panthenol, biotin, folic acid, and other water-soluble vitamins can be used as an aqueous solution. Here, one or two or more of the plurality of vitamins having properties different from those of the other vitamins are stored individually or in a plurality of combinations. In this classification, all vitamins can be stably maintained by individually storing a plurality of vitamins in separate storage rooms. However, when storing a large number of vitamins in the container body 1, a large number of compartments are required. Room 15
Since a, 15b, 15c,... are required, the production is troublesome. Therefore, when classifying a large number of vitamins, vitamins having the same or similar properties can be classified and combined. Properties of this vitamin include, for example, differences between fat-soluble vitamins and water-soluble vitamins, differences in stable pH range in simple preparations, differences in adsorptivity to the inner wall of the container, differences in stability to light or air, Examples include the difference between liquids, the difference between interactions between vitamins or between other components, and the like. The classification based on these properties can be applied independently, but by applying the classification based on a plurality of properties together, more vitamins can be stably maintained.

In addition, the stable p
The H range refers to a condition in which the vitamin-containing liquid alone maintains the optimal conditions such as light, temperature, gas, etc. for a long period of time alone, for example, for 2 hours.
It refers to a pH range where the residual ratio is 90% or more when stored for 4 months, and is, for example, a value as shown in Table 1 below.

Table 1 Table 1 Vitamin name Stable pH range Vitamin A 3.0-5.0 Vitamin E 5.0-7.0 Vitamin K 6.0-8.0 Vitamin B1 2.5-4.5 Vitamin B25 0.0-7.0 Vitamin B6 3.0-4.0 Vitamin B12 4.0-5.5 Vitamin C 5.6-7.4 Nicotinic acid 5.0-7.0 Panthenol 5.0-6.0. 0 Biotin 6.0-7.0 Folic acid 8.0-11.0

The interaction between each vitamin or with other components will be described later together with the description of each vitamin.

Next, the contents accommodated in the infusion container of this embodiment will be specifically described. Examples of the sugar-containing liquid to be stored in the storage chamber 3 include a solution obtained by dissolving one or more kinds of reducing sugars such as glucose, fructose and maltose, and sugar alcohols such as xylitol, sorbitol and glycerol in an aqueous solvent such as water. No. This sugar-containing solution has a pH value so that the sugar does not decompose during heat sterilization and storage.
Is preferably adjusted. In this case, unlike the conventional infusion containing various kinds of vitamins, it is not necessary to set the pH to a low pH which is set to improve the storage stability of the vitamins. It is sufficient that stability during sterilization or storage can be ensured. The pH of the sugar-containing liquid varies depending on, for example, the composition of other components such as an electrolyte described below, but is preferably about 4 to 5. As the pH adjuster, known ones used for sugar-containing liquids can be used, for example, citric acid, gluconic acid,
Examples thereof include organic acids such as lactic acid, malic acid, maleic acid, and malonic acid, inorganic acids, organic bases, and inorganic bases such as caustic soda. The sugar content in the sugar solution is preferably adjusted to 15-60% by weight in a state of being mixed with an amino acid-containing solution described below at the time of administration.

On the other hand, the amino acid-containing liquid stored in the storage chamber 5 includes L-isoleucine, L-leucine, L-valine, L-methionine, L-phenylalanine, L-tyrosine, L-tryptophan, L-threonine, L-arginine, L-histidine, L-alanine, L-proline, L-serine, glycine, L-lysine, L-aspartic acid, L-glutamic acid, L-cysteine, L-cystine, L-oxyproline, etc. Examples include a solution in which essential amino acids and / or non-essential amino acids used for infusion are appropriately dissolved in an aqueous medium. The pH of the amino acid-containing solution is preferably 5 to 7, more preferably 5.5 to
It is preferable to set the range to 6.5. As the pH adjuster, known ones used for sugar-containing liquids can be used,
Examples thereof include organic acids such as citric acid, gluconic acid, lactic acid, malic acid, maleic acid, and malonic acid, inorganic acids, organic bases, and inorganic bases such as caustic soda. The amount of the amino acid in the amino acid-containing solution is not particularly limited, but is preferably 1
It is preferable to adjust the content to a range of −15% by weight, more preferably a range of 3 to 12% by weight. The accommodation room 5 contains a part of the plurality of vitamins together with the amino acid-containing liquid.

The storage chambers 3 and 5 can contain various electrolytes together with the sugar-containing liquid or the amino acid-containing liquid. Examples of such an electrolyte include sodium, potassium, magnesium, calcium, chlorine, phosphorus, zinc and the like, and these can be appropriately selected and added. Each electrolyte can be added to either the acidic sugar-containing solution or the amino acid-containing solution, or may be added to both. Sodium hydroxide, sodium chloride, organic acid sodium salt, amino acid sodium salt, sodium monohydrogen phosphate,
Sodium dihydrogen phosphate and the like, potassium source, potassium hydroxide, potassium chloride, organic acid potassium salt, amino acid potassium salt, potassium monohydrogen phosphate,
Potassium dihydrogen phosphate and the like can be mentioned, as the magnesium source, magnesium chloride, magnesium sulfate, organic acid magnesium salt, amino acid magnesium salt and the like can be mentioned. As the calcium source, calcium chloride, calcium gluconate and the like can be mentioned. The chlorine source includes hydrochloric acid, sodium chloride, potassium chloride, amino acid hydrochloride, and the like. The phosphorus source includes phosphoric acid, sodium monohydrogen phosphate, sodium dihydrogen phosphate, monohydrogen phosphate. Sources of zinc such as potassium and potassium dihydrogen phosphate include zinc sulfate, zinc chloride, zinc gluconate, zinc lactate, and zinc acetate. Such an electrolyte is
It is preferable to add the necessary amount in the living body so as not to be excessive. After mixing the sugar-containing solution and the amino acid-containing solution, sodium is 0 to 180 mEq / L and potassium is 0 to 13
5 mEq / L, 0-50 mEq / L for calcium, 0-40 mEq / L for magnesium, 0-300 m for chlor
Eq / L and phosphorus can be added so as to be about 0 to 100 mEq / L.

If calcium or magnesium in the electrolyte and phosphoric acid as phosphorus are mixed in a non-acidic infusion, crystals may be precipitated.
It is preferable to store in a separate storage chamber, and when calcium or magnesium is added to one of the non-acidic sugar-containing liquid or amino acid-containing liquid, it is preferable to add a phosphate compound to the other. In addition, the sugar-containing liquid and the amino acid-containing liquid, in addition to the electrolyte, iron, copper, zinc, manganese, a necessary amount of trace elements such as iodine, if necessary,
For example, 0 to 70 μmol of iron and 0 to 10 μmo of copper
1, zinc 0 to 120 μmol, manganese 0 to 40 μmo
l, iodine can be contained in an amount of 0 to 2 μmol.
These trace elements can come from water-soluble salts such as chlorides, sulfates, acetates, gluconates and lactates. Such an electrolyte and a trace element are blended so that the stability during the production process and during storage is as high as possible.

The amount of the sugar-containing solution and the amino acid-containing solution to be stored in each storage chamber is generally about 200 to 1500 ml, and is about 500 to 2000 ml at the time of mixing. Can be adjusted as appropriate according to the shape of the device. However, in any case, in consideration of safety to a living body and irritation to a patient, a pH of 5 to 8, preferably 5.5 to 5.5 in a mixed state.
It is necessary to prepare to be about 7.0.

Next, the compartments 15a, 15b, 15c,.
・ Vitamins contained in the food will be explained. As the vitamins, as described above, vitamin A, vitamin D,
Vitamin E, Vitamin K, Vitamin B1, Vitamin B
2, vitamin B6, vitamin B12, vitamin C, nicotinic acids, pantothenic acids, folic acid, biotin and the like. First, examples of vitamin A include retinol palmitate and the like. It is preferred that the amount be 1250 to 10000 IU per dose. Examples of vitamin D include cholecalciferol and ergocalciferol. It is preferred that the amount be 10 to 1000 IU per dose. Examples of vitamin E include dl-α-tocopherol and tocopherol acetate. The amount is preferably 2 to 20 mg per dose. Vitamin K includes phytonadione, menatetrenone, menadione and the like. This amount is 0.2-per dose.
Preferably, it is 10 mg. Examples of the vitamin B1 include thiamines such as thiamine hydrochloride, fursultiamine, prosultiamine, and octiamine. This amount is preferably 1 to 12 mg per dose. The vitamin B1 is known that there is interaction between the SO ₃ ^2-ions, preferably housed in isolated storage chamber or compartment with the ions.
Vitamin B2 includes ribofuran, ribofuran phosphate, flavin mononucleotide, flavin adenine dinucleotide and the like. This amount is preferably 1 to 10 mg per dose. This vitamin B
It is known that 2 has an interaction with vitamin C and promotes the decomposition of vitamin C, and it is preferable to house it in a storage room or compartment different from vitamin C. Examples of vitamin B6 include pyridoxine, pyridoxal, pyridoxamine and the like. The amount is preferably 1 to 30 mg per dose. Examples of vitamin B12 include cyanocobalamin and the like. This amount is preferably 1 to 30 μg per dose. It is known that this vitamin B12 has an interaction with vitamin C and promotes decomposition, and it is preferable to store the vitamin B12 in a storage room or compartment different from that of vitamin C.

Examples of the vitamin C include ascorbic acid, sodium ascorbate, ascorbic acid palmitate, ascorbic acid dipalmitate, and magnesium ascorbic acid phosphate. The amount is preferably 20 to 250 mg per dose. This vitamin C has an interaction with vitamins B2, B12 and folic acid, and is decomposed when coexisting with vitamin B2. When coexisting with vitamin B12, it promotes the decomposition of vitamin B12. It is known that they are suspended, and it is preferable to store them in a storage room or compartment different from vitamins B2, B12 and folic acid. Vitamin C has a strong reducing property and easily interacts with other components. Furthermore, since it is liable to be oxidized when heated, it is preferable to coexist an antioxidant when housed in a container which is subjected to heat sterilization or the like. Since the antioxidant is an unnecessary component for the living body, it is necessary to reduce the amount of the antioxidant, but the antioxidant must have a certain concentration to obtain a sufficient antioxidant effect. Therefore, if vitamin C is accommodated in the accommodation room, the amount of co-existing infusion is excessively large as compared with vitamin C alone, so that a large amount of antioxidant must be used to obtain a sufficient antioxidant effect. However, when stored in a compartment separate from the infusion, there is no component that is present in a large amount as in the infusion, so even if the concentration of the antioxidant is adjusted to a sufficient antioxidant effect, the amount used can be reduced. It is much less than when housed in an accommodation room.
Thus, it is preferred that this vitamin C is preferably stored alone in the compartment. Nicotinic acids include nicotinic acid, nicotinamide and the like. This amount is preferably 5 to 50 mg per administration. Examples of pantothenic acids include sodium pantothenate, calcium pantothenate, pantothenol and the like. The amount is preferably 1 to 30 mg per dose. Folic acid is preferably used in an amount of 0.1 to 1 mg per dose. It is known that folic acid has an interaction with vitamin C, and it is known that a vitamin-containing liquid is suspended when coexisting. Therefore, it is preferable that folic acid be stored in a storage room or compartment different from vitamin C. Biotin is preferably incorporated in an amount of 0.01 to 0.3 mg per dose.

In the present invention, such a vitamin is added to the compartment 1
To accommodate in 5a, 15b, 15c, etc., it is preferable to accommodate as a vitamin-containing liquid. Vitamin B1, B
2. To make water-soluble vitamins such as B6, B12, C, nicotinic acids, pantothenic acids, biotin, and folic acid into a vitamin-containing liquid, the vitamin-containing liquid is prepared by dissolving the liquid using, for example, sterile water. Vitamins A, D, E, K,
In the case of fat-soluble vitamins such as those described above, they are solubilized using a solubilizing agent and dispersed in sterilized water to obtain a vitamin-containing liquid. Examples of the solubilizer include polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, and ethylene glycol / propylene glycol block copolymer. Furthermore, these vitamin-containing liquids are preferably adjusted to a stable pH value of a simple preparation of the contained vitamin. For this pH adjustment, citric acid, gluconic acid,
Organic acids such as lactic acid, malic acid, maleic acid, and malonic acid, and other organic acids, organic bases, and inorganic bases can be used. In this embodiment, it is preferable that at least two or more, preferably five or more, more preferably nine or more of the above-mentioned vitamins are accommodated in a plurality of compartments 15a, 15b, 15c. Most preferably, it contains 13 vitamins.

Since such vitamins are unstable, they are not only affected by the above-mentioned interaction with pH and other coexisting vitamins, but also by conditions such as light, air, heat, etc. It is also necessary to consider the effects of the components. Conventionally, when vitamins are blended into an infusion, taking these various conditions into account, combining vitamins and other components so that the vitamins can be stored in a stable state as much as possible, and establishing a stable combination that is established only for that specific combination. Formed a system. In this embodiment, a plurality of vitamins are stored in a container main body 1 having a plurality of compartments that are classified according to various properties and are easy to manufacture and easy to mix, without forcibly dissolving a plurality of vitamins in an infusion. Ensure that it can be easily and reliably maintained. Since the properties of each vitamin are different in some way, it is preferable to isolate all vitamins individually in different compartments and storage rooms. However, if there are many types of vitamins to be mixed in the infusion, many compartments are required. In this case, although the manufacture and sealing of each compartment are easy in the container body 1, a large number of filling mechanisms are required, and the filling device is complicated. Therefore, when a large number of vitamins are blended, a plurality of vitamins may be classified by combining specific or identical ones with the same or similar properties, and housed in different compartments so as to be isolated from each other for each classification. preferable. In this case, it is most preferable to classify the vitamin into an optimal number and segregate and store the vitamin in the compartment in consideration of the balance between the stability of the vitamin and the efficiency in the manufacturing process.

Here, for example, two or more, preferably three to nine, more preferably three to five compartments 15a, 15b, 15c...
5 contains at least some of the vitamins classified and isolated from other vitamins. Although this classification is not limited at all, it is preferable that water-soluble vitamins and fat-soluble vitamins can be housed separately, and from the viewpoint of stable pH of simple vitamin preparations, simple Vitamins having different stable pH ranges can be stored separately. Isolating and accommodating vitamins having different stable pH ranges in the plain formulation respectively means that the stable pH ranges in the plain formulation overlap each other, and form different compartments 15a, 15b, 15c,.
・ It means that it is accommodated in the accommodation rooms 3 and 5.

When combined from such a viewpoint, for example, among the plurality of compartments 15a, 15b, 15c,..., One compartment 15a contains fat-soluble vitamins and the remaining compartments 15b, 15c,.・ Adjust the inside to a different pH from that of accommodation rooms 3 and 5, and adjust the water-soluble vitamins to a stable pH.
... in the compartments 15b, 15c, ... according to the area,
Alternatively, among the water-soluble vitamins, those having a particularly low stable pH range, such as vitamin B1, may be housed in a separate compartment alone, or may interact with other vitamins, such as vitamin C, to provide an antioxidant. Many necessary items can be housed separately in separate compartments. Here, p in the accommodation rooms 3 and 5
H and p of any of the compartments 15a, 15b, 15c...
H may be the same. More specifically, in the case of the container body 1 having three compartments 15a, 15b, and 15c, the compartment 15a contains a fat-soluble vitamin, and the compartment 1
By setting 5b and 15c to different pH values, water-soluble vitamins can be accommodated in both chambers according to the stable pH range. For example, in the compartment 15a, vitamins A, D, E, K,
B2 and C are accommodated at pH 4-6, compartment 15b contains vitamins B1, B6 and B12 at pH 3-5, and compartment 15C contains panthenol, biotin, folic acid and nicotinic acid at pH 5-5. 7 can be adjusted. Also,
In the case of the container body 1 having four compartments 15a, 15b, 15c and 15d, vitamins A, D,
E, K, and B2 are accommodated at pH 4-6, and compartment 15b is accommodated with vitamins B1, B6, and B12 at pH 3-5.
Vitamin C is stored in the compartment 15c and the pH is 5.6-7.
4, panthenol, biotin, folic acid in compartment 15d,
The pH can be adjusted to 5 to 7 by containing nicotinic acid. In addition, five compartments 15a, 15b, 15
In the case of the container body 1 having c, 15d, and 15e, the compartments 15a contain vitamins A, D, E, K, and B2, and have
Vitamin B1 is stored in compartment 15b and pH is adjusted to 4-6.
2.5-4.5, Vitamin C is stored in compartment 15c to pH 5.6-7.4, and Vitamin B is stored in compartment 15d.
6, containing B12 to pH 4-6, compartment 15e containing panthenol, biotin, folic acid, nicotinic acid and p
H5 to 7 can be adjusted. Further, in this specific example, the fat-soluble vitamins A, D, E and K may be solubilized in a transparent state, but more preferably in an emulsified opaque state. be able to. By using such an opaque liquid, vitamins unstable to light, such as vitamin B2, are stored in the same room, so that the effects of light can be suppressed and stored stably.

The infusion container of the present invention contains a sugar-containing liquid,
The amino acid-containing liquid, the vitamin-containing liquid, or the fat-containing liquid may contain other drugs generally added to an infusion as long as stability is not impaired. Such other additives include, for example, buffers such as L-histidine and tris (hydroxymethyl) aminomethane, coloring inhibitors such as thioglycerol and dithiothreitol, thioglycerol, sodium bisulfite, sodium sulfite and the like. And an antioxidant.

In the present invention, the container body 1 for accommodating each of the above-mentioned contents is preferably a container made of a synthetic resin as described above. The container may have at least an inner layer having a resin layer whose safety is recognized as a medical container, and may have a non-resin layer as an outer layer. The container may be a rigid container, but is preferably a soft container when the partition portion is a weakly peelable seal. The resin of the medical container used for the inner layer of the infusion container of this embodiment is a resin that does not affect the medicine of the contents and does not generate eluted substances, such as a polyolefin resin, a polyester resin, and a polyacrylonitrile resin. ,
Polyacrylic resin, polyamide resin, vinyl chloride,
Vinylidene chloride resin, polyvinyl alcohol resin,
Resins such as an ethylene-vinyl acetate copolymer, an ethylene-acryl copolymer, and an ionomer are mentioned, and a polyolefin resin is particularly preferable. Examples of the polyolefin resin include low-density polyethylene, linear low-density polyethylene, medium-density polyethylene, high-density polyethylene, lower olefin resins such as polypropylene, cyclic polyolefin-based resins, ethylene-vinyl acetate copolymer, ethylene-acryl copolymer. A coalescence, an ionomer, or a mixture thereof is mentioned.

Further, the accommodation room partitioning portion 13a and the partitioning portion 13
When b, 13c, 13d, etc. are weak seals having easy peeling properties, as a resin used for the inner layer, a weak seal can be formed by incompletely welding the inner layers at a low temperature and at a high temperature. It is preferable to select a resin capable of forming a strong seal by completely welding. For example, a lower olefin resin can be selected, and a resin composed of a mixture of linear low-density polyethylene and polypropylene is particularly preferable. In the present invention, using such a resin for the innermost layer, a single layer, or as a multilayer resin laminate,
It can be used by welding a film, tube, or molded product formed by inflation molding, extrusion molding, injection molding, or blow molding as necessary. The container body 1 of this embodiment uses an inflation tube.

When storing fat-soluble vitamins such as vitamin D in the compartments 15a, 15b, 15c, 15d,...
As the resin of the innermost layer of the compartment, polyethylene terephthalate, polyethylene naphthalate, polyacrylonitrile, cyclic polyolefin, nylon and the like can be used. In this case, the other compartments 15a, 15b, 15
If the innermost layers of c, 15d, and / or the accommodation chambers 3, 5 are not formed of such a resin having low adsorptivity, a seal made of, for example, such a resin and capable of being opened by peeling or the like. A fat-soluble vitamin such as vitamin D may be stored in an independent container having a portion, and the independent container may be stored in the compartment. Vitamin D, A, and E, which may be changed by air, are supplied to the compartment 15.
a, 15b, 15c, 15d ... or accommodation rooms 3, 5
When housed in a resin layer, a resin layer having a low gas permeability may be laminated in order to reduce the gas permeability of the compartment or the accommodation chamber, and the surface, the back surface, both surfaces, or the intermediate layer of the resin layer may be laminated. A non-resin layer made of a metal, an inorganic substance, or the like may be stacked. As the resin having low gas permeability, polyethylene terephthalate, polyethylene naphthalate, polyvinyl alcohol, ethylene vinyl alcohol, polyvinylidene chloride,
Examples thereof include polyamides such as polyvinylidene chloride and nylon, and resins such as cellophane. Examples of the non-resin layer having low gas permeability include a metal thin film layer of aluminum or the like, a ceramic vapor deposition layer such as an alumina vapor deposition layer, and a silica vapor deposition layer.

Further, vitamin B which is easily changed by light
2, B6, B12, E, K, folic acid, etc.
15b, 15c, 15d... Or the accommodation chambers 3 and 5, the outer layer is covered with a light-shielding film or a colored film in order to reduce or block light incident on the compartment or the accommodation chamber. You may. Vitamin which is easily changed by air or / and light is supplied to compartments 15a and 15 respectively.
When stored in b, 15c, 15d, etc., only the compartment needs to be protected from air and / or light, and the amount of use of such materials can be reduced.

In order to manufacture an infusion container having such a structure, the lower end 7 and, if necessary, both sides of the infusion container 9 using a preformed inflation tube or a resin sheet with the discharge port 9 arranged in a conventional manner. Parts 17a, 1
7b is formed in a liquid-tight manner, the partitioning portion 13a and the partitioning portions 13b, 13c... Of the storage chamber are formed by weak sealing, and the separating portions 11a, 11b, 11c.
··· is formed by a strong seal. In this state, only the upper ends of the accommodation room 3 and the compartments 15a, 15b, 15c, 15d,... Are open. When the co-injection port 10 is disposed at the upper end 8, the upper end of the storage chamber 3 is sealed in the same manner as the discharge port 9, and the compartments 15a, 15b, 15c, 15d
・ ・ Open the upper end of. Then, the storage chamber 5 is filled with the sugar-containing liquid from the outlet 9 and the outlet is sealed. Next, the solution is turned over, the amino acid-containing liquid is filled from the opening of the storage chamber 3 or the co-injection port 10, and each compartment 15
a, 15b, 15c, 15d... are filled with vitamins, and the upper end 8 is tightly sealed. At this time, the filling and sealing operations of each chamber may be performed sequentially, but preferably, the compartments 15a, 15b, 15c, 15d
.. Are filled with a number of times smaller than the number of compartments by a filling facility having a plurality of filling ports, and the upper end 8 is strongly sealed, thereby sealing each chamber. It is also possible to form a hanging hook 18 with this strong seal.
Thereafter, the infusion container of this embodiment can be manufactured by performing a sterilization treatment if necessary.

In order to use the infusion container of this embodiment manufactured as described above, first, the accommodation room 5 is pressed from the outer wall of the container, so that the accommodation room partition portion 13a and the partition portions 13b, 13c. .. by peeling the weak seal between the accommodation room 5 and the accommodation room 3, and between the accommodation room 5 and each compartment 15
a, 15b, 15c, 15d,... In this case, the storage room partition 13a and the partition 13b,
13c are all weak seals, so that they can all be communicated at once. Then, the content liquid is stored in each of the storage chambers 3, 5
And flowing the compartments 15a, 15b, 15c, 15d... To sterilize the sugar or the sugar and electrolyte-containing solution, the amino acid or amino acid and electrolyte-containing solution, the vitamin, and, if necessary, the fat emulsion and the like. Mix. At this time, when other components not contained in the container body 1 are mixed, the other components are further injected from the mixing inlet 8 and mixed. Then, the drug is administered to a patient by being suspended by a suspension hook 20 and discharged from a discharge port 9 by a liquid sending tube or the like. At this time, the partition 13
., 13c, 13d,... are provided on the outlet 9 side, so that each of the compartments 15a, 15b, 1
5c... Can open downward, and the compartments 15a, 15b, 15c.
All the liquid inside can be discharged.

According to the above-described infusion container, a plurality of vitamins having different properties are isolated in a plurality of compartments 15a, 15b, 15c, 15d, and at least a part of vitamins and other vitamins are isolated. Thus, a plurality of vitamins can be stored under the optimum conditions for the respective vitamins. For this reason, it is possible to suppress the time-dependent changes in the vitamins to be incorporated in the infusion at the time of production and storage. Also, the compartments 15a, 15b, 1
The vitamins contained in 5c, 15d... Include a pH adjuster for ensuring the stability of the vitamin, a solubilizer for solubilizing fat-soluble vitamins, a buffer, a coloring inhibitor, and an antioxidant. Can be added, but because the amount of this vitamin is very small and there are no extra components,
Various components to be added to these vitamins may be trace amounts corresponding to the amount of vitamins, and when mixed with the infusion, the amount present in the infusion is extremely small. Therefore, even if such a component is sufficiently blended with the vitamin to obtain sufficient stability, the amount of these components unnecessary for a patient is significantly reduced as compared with a conventional infusion in which the vitamin is dissolved. Can be. Furthermore, when performing heat sterilization, the concentration of vitamins contained in the compartment is maintained at a higher concentration than conventional infusions, so that it is possible to suppress the degradation of vitamins during heat sterilization compared to conventional infusions. .

Further, a plurality of compartments 15a, 15b, 1
5c, 15d,... Are vertically separated.
1a, 11b, 11c,...
are separated from the storage chamber 5 in a liquid-tight manner by communicating partitioning portions 13b, 13c,... formed at least in the lateral direction continuously from b, 11c.
.. Can be easily mixed with the infusion without exposing many vitamins to the outside air. Moreover, a plurality of compartments 15a, 15b, 15c, 1
Are separated in a liquid-tight manner by isolation portions 11a, 11b, 11c,... Formed in the vertical direction of the container body 1, so that the compartments 15a, 15b, 15c, 15d,.
・ The width is small and the volume is small, and it is easy to confirm the filled vitamin, and it is possible to precisely fill a small amount of vitamin and easy to manufacture. Also, the compartments 15a, 15b, 15c ...
Is smaller than the accommodation room, especially 1 /
10 or less, so the compartments 15a, 15b, 15c
..The amount of liquid stored in the storage chamber is less than the amount of liquid stored in the storage chamber, and a small amount of vitamin is used together with a stabilizing agent such as a pH adjuster, a surfactant, and an antioxidant to optimize the vitamin. Even if the medicines are accommodated so as to have a concentration, the amount of the medicine used for stabilization can be smaller than that in the accommodation chambers 3 and 5. Further, the compartments 15a, 1
Since the volumes of 5b, 15c, 15d, etc. are small, the inner wall surface of the container body 1 in contact with the fat-soluble vitamin is small, and the components for modifying the interface of the fat-soluble vitamin are sufficiently converted into vitamins at a high concentration. Since the fat-soluble vitamin such as vitamin D, which is present only in a trace amount, can be prevented from being adsorbed and reduced on the container wall.

The plurality of compartments 15a, 15b, 15
., 15d... and the accommodation rooms 3 and 5 are
Are partitioned in the vertical direction of the container main body 1 by 3c..., And compartments 15a, 15b, 15c, 15d.
Since the compartments b, 11c,... are liquid-tight, if the container is held with the accommodation room 5 down after filling the infusion into the accommodation room 5, the center of gravity is low and the stability is good. Each compartment 15
a, 15b, 15c, 15d,... are filled with vitamins in the vertical direction of the container body 1, so that the accommodation room 5
A plurality of compartments 15a, 15b, 15c, 15
When vitamins are filled in d..., the container main body 1 is more easily held stably and the filling is easier than when the container main body 1 is laterally held and filled.

The compartments 15a, 15b, 15c, 1
Since the pH of the vitamin-containing liquid contained in 5d... Is different from the pH of the sugar-containing liquid and the amino acid-containing liquid in the storage chambers 3 and 5, the pH of the sugar-containing liquid and the amino acid-containing liquid is in a stable pH range. By storing certain vitamins in a mixture with an infusion, compartments can be reduced. Further, a plurality of compartments 15a, 15b, 15c, 15d,.
Are arranged laterally adjacent to each other via the isolation portions 11a, 11b, 11c,..., So that a plurality of vitamins can be supplied to the plurality of compartments 15a, 15b, 15c, 1 during the manufacturing process.
5d, the plurality of compartments 15a, 1
5b, 15c, 15d... Can be arranged sideways in a state where the upper ends thereof are opened, so that if a plurality of vitamin filling ports are used, a plurality of vitamins can be simultaneously placed in separate compartments 15a, 15b, 15c, 15d, respectively. .. And can be easily manufactured. In addition, the isolation units 11a, 1
1b, 11c... Are made of non-peelable strong seals, and the partitions 13b, 13c, 13d.
Are easy to manufacture, and the weak seals of the partitions 13b, 13c, 13d... Only press the storage chambers 3 and 5 or separate the container walls from each other to form all the compartments. 15a, 15b, 15c, 15d ...
And the storage chambers 3 and 5 can be communicated, and the mixing operation of the sugar-containing liquid and the amino acid-containing liquid with a plurality of vitamins can be performed at one time, and the mixing operation is easy. Also, since the isolation parts 11a, 11b, 11c... Are strong seals, the weak seal parts of the compartments 15a, 15b, 15c, 15d. As a result, the liquid tightness of the compartment can be maintained.

Further, the partitions 13b, 13c, 13d
.. are continuous through both sides 7a, 7b of the container body 1, so that a plurality of compartments 15a, 15b, 15c, 1
When forming 5d..., The number of partitions is small, manufacturing is easy, and the partitions 13a, 13b, 13c, 13
By folding the container body 1 at the positions d, the compartments 15a, 15b, 15c, 15d, and the storage chamber 3 can be reliably maintained in a liquid-tight state with the storage chamber 5. Therefore, the partition portion is not destroyed by external pressure during storage, and storage stability can be further ensured.
At the same time, the isolation portions 11a, 11b, 11c,... Are non-peelable strong seals.
a, 13b, 13c, 13d,... while the container is folded and maintained.
Is not destroyed and there is no risk of communication between the compartments and between the storage chambers 3 and 5, and the compartments can be more reliably maintained in a liquid-tight state. In addition, the upper end 8 of the infusion container is sealed by a strong seal that cannot be peeled off, and the strong seal seals the compartment 1.
The upper ends 16a, 1a of 5a, 15b, 15c, 15d...
6b, 16c... Are sealed, so that the sealing operation of the compartments 15a, 15b, 15c, 15d. . In addition, the container body used for the medical container containing an infusion as described above can be particularly preferably used for accommodating an infusion component and a plurality of vitamins, but can be used for other purposes. Multiple trace elements and multiple components, such as containers that contain multiple trace elements in multiple compartments and contain infusions, as well as food containers that contain multiple small amounts of seasonings and large amounts of seasonings and food, etc. It can also be used as a container for other uses for keeping the container isolated.

Next, a modification of the embodiment shown in FIG. 1 will be described. This modified example is the same as the above embodiment except that an amino acid and an electrolyte are stored in the storage chamber 3 and fat is stored in the storage chamber 5. In the present invention, even with an infusion container having such a configuration, exactly the same effects can be obtained without any difference from the above. In this example, the fats contained in the accommodation room 5 include vegetable oils such as cottonseed oil, sesame oil, peanut oil, olive oil, safflower oil, soybean oil, safflower oil, corn oil, coconut oil, perilla oil, perilla oil, and medium chain. One or more selected from fatty acid triglycerides and the like can be used. These are generally stored in the storage chamber 5 in the form of a fat emulsion. This fat emulsion is an oil-in-water emulsion in which fat is emulsified using an emulsifier and / or an emulsifier, and is preferably made into fine particles and stabilized. Such fat emulsions
It can be produced by a conventional method. For example, a fat and an emulsifier and / or an emulsification aid are added to an aqueous medium such as water, and a coarse emulsion is prepared by vigorous stirring. It can be obtained by emulsification by a high-pressure emulsification method or the like. The content of fat in the fat emulsifier may be, for example, 5 to 15%. As an emulsifier,
Egg yolk phospholipids, soybean phospholipids, nonionic surfactants, and the like. Examples of the emulsification aid include higher fatty acids, intermediate fatty acids, and basic amino acids. In addition, this fat emulsion may contain a polyhydric alcohol such as glycerin for the purpose of stabilizing the system, and may contain other drugs conventionally used in infusions. Is possible, and may further contain a sugar and / or an electrolyte as described above.

By the way, vitamins have been conventionally blended into fat emulsions. As a method for this, a method is known in which fat-soluble vitamins are blended into fat at the time of production and emulsified together with fat. However, when fat is emulsified in the presence of a fat-soluble vitamin, an emulsifier or an emulsifier must be added at a somewhat higher concentration than when emulsifying with fat alone. Since fat is present in a much larger amount than the amount of fat-soluble vitamin, to increase the concentration even slightly, it is necessary to use an emulsifier or an emulsifier in an amount corresponding to the amount of fat. for that reason,
The vitamin-containing fat emulsion thus obtained contains a clearly excessive amount of an emulsifier and an emulsifier in comparison with a case where the fat-soluble vitamin is formulated alone. The emulsifier and the emulsifier are usually unnecessary components for the patient,
In such a fat emulsion, the abundance of unnecessary components is large. Therefore, in the present embodiment, when the fat emulsion is stored in the storage chamber, it is preferable that the solubilized fat-soluble vitamin is stored separately from the fat emulsion in the compartment or the storage chamber. In this way, even if a sufficient amount of solubilizing agent is used to solubilize the fat-soluble vitamin, only a small amount of the fat-soluble vitamin is incorporated. The amount can be reduced as compared with an emulsifier or an emulsifier when emulsifying with a lipid.

In the above-described example in which the sugar, amino acid, and electrolyte are accommodated, or in the example in which fat is accommodated, an example in which the container body has two accommodation chambers has been described.
There is no particular limitation. For example, a container body in which one or two or more of a sugar-containing liquid, an amino acid-containing liquid, a fat emulsion, and an electrolyte-containing liquid are accommodated in a single accommodation chamber and a plurality of compartments are provided. It is possible to obtain the same effect as described above. Further, the same effect can be obtained even when three or more communication chambers are provided and each infusion component is housed in a state of being isolated from each other. Is obtained. In the case where a plurality of storage chambers are provided as in the above-described embodiment, the arrangement of the respective liquids may be any, and the larger the amount, the lower the position. Furthermore, as the partition, an example of a peelable weak seal portion has been described. It may be one that is closed at the time of storage and is broken at the time of use to allow communication between the multiple chambers. On the other hand, a strong seal is illustrated as an example of the isolation part. If each compartment is kept in an isolated state, it can be applied to the medical container with contents of the present invention. By doing so, it becomes possible to peel off the partitioning part and the separating part at the time of use, and it is preferable because the inside of the container becomes a single chamber at the time of use and mixing of each component becomes extremely easy. This is preferable because the isolation part can be easily maintained in a sealed state.

In each of the above embodiments, the partition of the compartment is illustrated linearly. However, in order to facilitate the separation of the partition,
For example, as shown by a broken line in FIG. 1A, connecting portions 13z, 13y, 13 formed in a vertical direction at a joint portion with the isolation portion.
x ... may be provided. Further, in the above, all the compartments contain vitamins. However, there is no problem even if, for example, some compartments contain components other than vitamins. For example, only other components such as trace elements, glutamine, etc. Or 2
It is also possible to store in the above compartments. Also,
In the example of the embodiment, the example in which the vitamin is stored in the compartment as the vitamin-containing liquid has been mainly described. Can be manufactured and used without. Further, in the above, the case of autoclaving the infusion container has been described.However, the sterilization method is not limited at all. It may be performed by aseptic filling in which the contained liquid and various vitamins are filled under aseptic or sterile atmosphere, respectively.

Next, another embodiment will be described. FIG.
(A)-(c) is the front view, longitudinal cross section, and cross sectional view which show the infusion container of another embodiment, respectively. In this infusion container, the positions of the compartments 15a, 15b, 15c...
Is different from the upper end 16a, 16b, 16c... Of the compartments 15a, 15b, 15c. The upper ends 16a, 16 of the chambers 15a, 15b, 15c ...
are weak seals 21 having easy peelability.
a, 21b, 21c ... are liquid-tightly partitioned. The rest is the same as the infusion container of FIG. According to such a container, the same effects as those of the above-described embodiment can be obtained, and both ends of the compartments 15a, 15b, 15c... Are sealed by peelable weak seals 21a, 21b, 21c. When the mixing is performed, the infusions can be performed by pressing the storage chambers 3 and 5 to release the partitions 13a, 13b, 13c, 13d... And the weak seals 21a, 21b, 21c. Narrow width compartments 15a, 15
b, 15c... easily flow through the inside, so that the mixing operation of the infusion solution and the vitamin-containing solution is easy.

FIGS. 3 (a) to 3 (c) are a front view, a longitudinal sectional view and a transverse sectional view showing an infusion container of still another embodiment. The container main body 1 of the infusion container includes a compartment 15a,
The positions of 15b, 15c... Are different from those of the container of FIG. 1, and the partitions 13b, 13c, 13d.
a, the compartments 15a, 15b,
The upper ends 16a, 16b, 16c,... Of 15c are integrally sealed by a strong seal 19 on the upper end 8 of the container body 1. Others are the same as FIG. In such an infusion container, the same effect as that of the infusion container of FIG. 1 can be obtained. In particular, even if the vertical length of each of the compartments 15a, 15b, 15c,... Is shorter than that of the container of FIG. 1, the opening of the compartments 15a, 15b, 15c,. Because the upper end 8 can be opened,
The compartments 15a, 15b, 15c compared to the infusion container of FIG.
... is easy to fill. In addition, in this embodiment, the accommodation room partition part 13a and the partition parts 13b, 13c, 1
3d are not linearly continuous, and it is difficult to bend the infusion container 1 at these partitions in order to prevent the partitions 13b, 13c, 13d. It is. Therefore, in this infusion container, the compartment 13a or the compartments 13b, 13c,
With a clip having a pressing surface corresponding to 13d..., The sealing portion of the partition portion can be sandwiched from the outside of the container body 1 so as to be compressed and stored.

FIG. 4 shows an infusion container according to still another embodiment, wherein (a) is a front view, (b) is a longitudinal sectional view, and (c).
Is a cross-sectional view thereof. In this embodiment, the compartment 15
are formed in the first divided container 31 via the isolation portions 11b, 11c, 11d,..., and the storage chambers 3, 5 are formed in the second divided container 3.
3 are formed so as to be able to communicate with each other via a storage chamber partitioning portion 13a, and the two divided containers 31, 33 are liquid-tightly joined by joining members 35 at the partitioning portions 34a, 34b. The partition part 34a is formed of an easily peelable weak seal formed to seal the compartments 15a, 15b, 15c,... Formed in the lower part of the first divided container 31.
., 13c, 13d,.
., 13d... and a sterile connecting portion 37a extending without welding the inner wall surfaces facing each other. On the other hand, the partitioning part 34b includes a storage chamber upper partitioning part 39 formed of an easily peelable weak seal formed to seal the storage chamber 3 above the second divided container 33, and a storage chamber upper partitioning part. 39 and a sterile connecting portion 37b extending in a state where the opposing inner wall surfaces are not welded to each other. Then, a part of the sterilized connection portion 37a and the sterilized connection portion 37b is covered from outside by the joining member 35, and the sterilized connection portion 37a and the connection member 35, and further, the sterilized connection portion 37b and the connection member 35 are strongly sealed. By sterilizing the insides of the sterilizing connection portions 37a and 37b and the connection member 35 by ultraviolet irradiation, electron beam irradiation, xenon pulse irradiation, etc.
1, 33 are liquid-tightly joined. Others are the same as the infusion container of FIG.

In such an infusion container, the storage chamber 3 is formed in the middle part of the container with upper and lower sides partitioned by weak seals. Alternatively, it becomes difficult to fill the liquid containing the sugar and the electrolyte. Therefore, the divided containers 31, 33
After being separately housed and joined, the filling of the housing chamber 3 located in the middle becomes remarkably easy, and the divided containers 31 and 33 can be sterilized separately, which facilitates manufacture. In addition, since the inside of the connection portion between the divided containers 31 and 33 can be easily sterilized, sterility can be ensured. In this embodiment, the divided containers 31 and 33 are connected by using the connection member 35, but the sterilization connection portions 37a and 37b can be directly connected to each other without the connection member. In this case, the sterile connection portion 37 formed in a cylindrical shape is used.
a and 37b may be inserted into the inside of the other, and may be joined by liquid-tight welding at the insertion portion. As in the above case, the sterility of the connection portion can be easily ensured, and the manufacturing is easy. is there.

FIG. 5 is a front view showing an embodiment of the present invention.
FIG. 6 and FIG. 6 are longitudinal sectional views thereof. Double room of this embodiment
The container 21 is a container body 2 having a plurality of accommodation chambers 23 and 24.
5 and a plurality of compartments 28 and accommodated in the accommodation room 24.
In this case, the container 23 is
Contains amino acid or amino acid and electrolyte containing solution
The chamber 24 contains sugar or a solution containing sugar and electrolyte.
I have. On the other hand, at least two or more compartments 28
The above vitamins, at least some of the vitamins other vitamins
Separately housed to separate from Min, but other
Some of the vitamins are further stored in storage rooms 23 and 24
May be. In the container body 25 of the multi-chamber container 21,
The inner walls of the container wall 31 are peeled off between the number of accommodation chambers 23 and 24.
The partitioning part 33 made of a weak seal that is heat-welded so that it can be separated
The periphery, which is partitioned and includes the upper and lower ends, is hermetically sealed.
5 sealed. With this hermetically sealed portion 35
The inside of the sealed container wall 31 is a storage space 37. Ma
In addition, the lower end of the sealing portion 35 is
It has an outlet 38 for goods and is sealed with a rubber stopper etc.
ing. In the storage container 30, the inner wall surfaces of the wall material 39 are peeled off from each other.
Due to the partition 41 made of a strong seal that is irremovably heat-welded
The space between the side portions 30 a and the compartment 28 is partitioned, and
A gap consisting of a weak seal heat-welded so that the inner walls can be peeled off
The lower end is separated from the storage chamber 24 by the separating portion 43, and the container
The upper end portion is disposed on the hermetically sealed portion 35 of the body 30 so as to be integrated.
Sealed by welding. This compartment 41
Are provided, but the figure shows an example of three rooms.
I have. In addition, the sealing portion 35, the partitioning portion 41, and the separating portion 4
The interior of the wall material 39 partitioned by 3 is a partition room 2
It is one. This compartment 28 is smaller than the accommodation
Or less than 1/10 of the volume of the accommodation room 24.

Further, the separating portion 43 of the storage container 30 is welded to a strength that can be peeled and opened by pressing the wall material 39 of the compartment 28. Further, the container wall 31 of the container body 25 is flexible enough to press the wall material 39 of the container 30 via the container wall 31, and furthermore, the container space is sealed by accommodating the container. The deformable amount in the closed state is smaller than the openable amount of the separating part 43 in the non-communication state of the partition part 33, that is, in the state before the communication, and in the communicating state of the partition part 33, that is, in the state after the communication, 43 is larger than the openable amount. Here, the deformable amount of the container wall 31 of the container body 25 refers to the container 30
This is the amount by which the container wall 31 can be deformed when the container wall 31 corresponding to the storage chamber 24 in which the container wall 31 is deformed such as pressing, pulling apart, or distorting. This amount is
Usually, it is proportional to the difference between the full capacity of the storage room 24 or the storage space 37 and the storage amount of the storage material, and varies depending on various factors such as the flexibility of the container wall 31, the compressibility of the storage material, and the temperature. In other words, when the storage volume of the storage chamber 24 storing the storage container 30 is full, the storage capacity is minimum, and when the storage capacity is empty, the storage capacity is maximum. The opening amount of the isolation portion 43 of the storage container 30 is defined as the amount of opening of the isolation portion 43 when the opening operation of the isolation portion 43 is performed via the container wall 31 corresponding to the storage space 37 in which the storage container 30 is stored. Container body 25 required for opening
Of the container wall 31 of FIG. The amount that can be opened differs depending on the method of opening the isolation portion 43. For example, in a container that breaks the wall material, the container wall of the container body necessary to deform the wall material of the storage container to such an extent that the wall material is broken is generated. In a so-called click-tip type container in which communication is performed by breaking a member that closes a communication hole formed in advance, a so-called click-tip type container is required to break a container wall of a container body necessary to break the closing member of the communication hole. The amount of deformation. In this embodiment, by pressing the wall material 39 of the storage container 30 via the container wall 31, the internal pressure of the compartment 39 is increased to separate the isolation portion 43 formed of a weak seal, and the separation occurs. This is the amount of deformation of the container wall 31 of the container body 25 required to deform the wall material 39 of the storage container 30 to a certain extent.

Also in such a multi-chamber container 21, at least two or more kinds of vitamins are separately housed so as to isolate at least a part of vitamins from other vitamins, so that the same effect as in the above embodiment can be obtained. In addition,
Since the compartment 28 is provided in the accommodation room 24, the contents in the compartment 28 are hardly affected by the atmosphere around the multi-chamber container 21, for example, oxygen such as oxygen in the outside air into the compartment 28. It is possible to suppress the permeation of gas, the release of volatile components such as water in the contents in the compartment 28 into the surrounding atmosphere, and to easily prevent the contents in the compartment 28 from being deteriorated during storage. Furthermore, at the time of heat sterilization, the contents in the compartment 28 of the storage container 30 are heated in accordance with the change in the temperature of the storage liquid in the container main body 25, and therefore are not subjected to excessive heat processing. Moreover, the storage container 30 provided with the isolation portion 43 that can be opened and opened via the container wall 31 of the container main body 25 is disposed in the storage room 24 partitioned by the partition 33 that can communicate with the container main body 25. Since the deformable amount of the container wall 31 is smaller than the openable amount of the separating portion 43 before the communication of the partition portion 33 and larger than the openable amount after the communication of the partition portion 33, the partition portion 33 is Only after communication can the isolation unit 43 be opened, and
The opening order of the compartments 3 and 24 and the compartment 28 can be specified. For this reason, the isolation part 43 cannot be opened unless the partition part 33 is communicated, so that the separation part 33 is prevented from opening both of the partition part 33 and the isolation part 43 simply by keeping the partition part 33 in a non-communication state. can do. In addition, the force required to open the isolation unit 43 can be set low. Further, the storage container 30 having the compartment 28 in which the heat-altering vitamin is stored is stored in the storage space 37 of the container body 25, and heating is performed in a state in which the storage liquid is stored in the storage space 37. Has been processed,
At the time of the heating process, the contents in the compartment 28 of the container 30 are heated according to the temperature change of the liquid stored in the container body 25.
Therefore, the temperature of the contents in the accommodation room 24 and the temperature of the compartment 2
8 is heated, and the contents of the compartment 28 are
Without reaching the heat treatment temperature faster than
No heat treatment is applied to the contents of the accommodation room 24 more. As a result, even if each of the compartments 28 is smaller than the storage chambers 23 and 24, it is possible to reliably prevent excessive heating of the contents of each of the compartments 28.

[0056]

Embodiments of the present invention will be described below. Example 1 The stability of vitamins was confirmed using an infusion container as shown in FIG. Sugar-containing solution First, the following components are dissolved in water for injection, and the pH is adjusted with citric acid.
600 ml of sugar and electrolyte containing solution adjusted to 4.5 were obtained. This liquid was stored in the storage chamber 5 through the outlet 9. Ingredient Compounding amount Dextrose 79.80 g Fructose 40.2 g Xylitol 19.80 g Sodium chloride 1.06 g Potassium chloride 1.27 g Sodium acetate 1.85 g Calcium gluconate 0.89 g Magnesium sulfate 0.49 g Zinc sulfate 2.28 mg Diphosphate Potassium hydrogen 0.68g

Amino Acid-Containing Liquid Next, the following components were dissolved in water for injection to obtain 250 ml of an amino acid-containing liquid adjusted to pH 6.5. This liquid was stored in the storage chamber 3 from the opening at the upper end 8 of the container body 1. Ingredient Compounding amount L-leucine 3.50 g L-isoleucine 2.00 g L-parin 2.00 g L-lysine acetate 3.70 g L-threonine 1.43 g L-tryptophan 0.50 g L-methionine 0.98 g L-phenylalanine 1.75 g L-cysteine 0.25 g L-tyrosine 0.13 g L-arginine 2.63 g L-histidine 1.25 g L-alanine 2.00 g L-proline 1.25 g L-serine 0.75 g aminoacetic acid 1.48 g L-aspartic acid 0.25 g L-glutamic acid 0.25 g

Vitamin-containing liquid Vitamin as shown in the following table was applied to each of the compartments 15a to 15a.
5f. The vitamin-containing liquid in each compartment is 5 ml in compartment e, 2 ml in compartments a, b, and d, and compartments c and f.
Was adjusted to 1 ml and dispensed as an aqueous solution or dispersion. The fat-soluble vitamin was previously solubilized using polysorbate 80 as a solubilizing agent. The solubilizer in the compartment containing the fat-soluble vitamin was 80 mg. Further, the vitamins contained in the compartment were accommodated by adjusting the pH using citric acid, hydrochloric acid or caustic soda. Vitamin B1 that uses the most acid in the compartment
The amount of hydrochloric acid used in the compartment 15a containing 0.1 cc was 0.1 cc of diluted hydrochloric acid used for medical purposes. Component Storage amount Storage position pH Vitamin A 3300 IU Compartment 15e 6 Vitamin D 5 μg Compartment 15e 6 Vitamin E 10 mg Compartment 15e 6 Vitamin K 5 mg Compartment 15a 6 Vitamin B1 3.9 mg Compartment 15a 3.5 Vitamin B6 4. 9 mg compartment 15a 3.5 vitamin B2 4.6 mg compartment 15b 6.3 vitamin B12 5 μg compartment 15d 5.2 vitamin C 100 mg compartment 15c 7.2 nicotinamide 40 mg compartment 15b 6.3 panthenol 14 mg compartment Room 15d 5.2 Biotin 0.06mg Compartment 15b 6.3 Folic acid 0.4mg Compartment 15f 8

Infusion container Sugar and electrolyte-containing solution, amino acid-containing solution, and vitamin as described above are contained in accommodation chambers 3, 5 and compartment 15a, respectively.
After being housed in 15b and 15c, respectively, and sealed by replacing with nitrogen gas, high-pressure steam sterilization was performed at 115 ° C. for 20 minutes to prepare an infusion container. Confirmation of stability
The liquid contents were withdrawn from the accommodation chambers 3, 5 and the compartments 15a, 15b, 15c, and the residual ratio of each vitamin was measured by a liquid chromatography method. Next, the infusion container was stored in a light-tight room at room temperature filled with nitrogen and stored for 3 months, and the residual ratio of each vitamin in the contents was measured in the same manner. Table 2 shows the results.

Example 2 The stability of each vitamin was confirmed in the same manner as in Example 1 except that the vitamins were blended and stored as follows, and the pH of the sugar and electrolyte-containing solution was set to 5. Each compartment is 5
cc. Table 2 shows the results. Component Storage amount Storage position pH Vitamin A 10000 IU compartment 15e 5 Vitamin D 1000 IU compartment 15e 5 Vitamin E-Vitamin K-Vitamin B1 50mg compartment 15a 3.5 vitamin B6 15mg compartment 15a 3.5 vitamin B2 10mg compartment 36.5 Vitamin B12-Vitamin C 500mg Compartment 15c 7.2 Nicotinamide 100mg Storage room 3 6.5 Panthenol 25mg Storage room 55 Biotin-folic acid-

Example 3 The stability of each vitamin was confirmed in the same manner as in Example 1 except that the vitamins were blended and stored as follows.
Each compartment was 5 cc. The fat-soluble vitamin was mixed with soybean oil and then mixed with polyoxy-hardened castor oil 60 to be solubilized. Table 2 shows the results. Ingredient Amount Amount Location pH Vitamin A 10000 IU Compartment 15b 5 Vitamin D 1000 IU Compartment 15b 5 Vitamin E 20mg Compartment 15b 5 Vitamin K 10mg Compartment 15b 5 Vitamin B1 50mg Compartment 15a 4 Vitamin B2 10mg Compartment 15b 5 Vitamin B6 15 mg compartment 15a 4 vitamin B12 30 μg compartment 15a 4 vitamin C 500 mg compartment 15b 5 nicotinamide 100 mg compartment 15c 6.1 panthenol 25 mg compartment 15c 6.1 biotin 0.3 mg compartment 15c 6.1 folic acid 1mg compartment 15c 6.1

Example 4 The stability of each vitamin was confirmed in the same manner as in Example 1 except that the vitamins were blended and stored as follows.
Each compartment was 5 cc. Table 3 shows the results. Ingredient Amount Amount Location pH Vitamin A 10000 IU Compartment 15b 5 Vitamin D 1000 IU Compartment 15b 5 Vitamin E 20mg Compartment 15b 5 Vitamin K 10mg Compartment 15b 5 Vitamin B1 50mg Compartment 15a 4 Vitamin B2 10mg Compartment 15b 5 Vitamin B6 15 mg Compartment 15a 4 Vitamin B12 30 μg Compartment 15a 4 Vitamin C 500 mg Compartment 15d 6.5 Nicotinamide 100 mg Compartment 15c 6.1 Panthenol 25 mg Compartment 15c 6.1 Biotin 0.3 mg Compartment 15c 6. 1 folic acid 1mg compartment 15c 6.1

Example 5 The stability of each vitamin was confirmed in the same manner as in Example 1 except that the vitamins were blended and stored as follows.
Each compartment was 5 cc. Table 3 shows the results. Ingredient Amount Amount Location pH 10000 IU Vitamin A compartment 15b 5 Vitamin D 1000IU compartment 15b 5 vitamin E 20mg compartment 15b 5 vitamin K 10mg compartment 15b 5 vitamin B1 50mg compartment 15e 3.5 vitamin B2 10mg compartment 15b 5 Vitamin B6 15mg Compartment 15a 4 Vitamin B12 30μg Compartment 15a 4 Vitamin C 500mg Compartment 15d 6.5 Nicotinamide 100mg Compartment 15c 6.1 Panthenol 25mg Compartment 15c 6.1 Biotin 0.3mg Compartment 15c 6.1 folic acid 1mg compartment 15c 6.1

[0064]

Table 2 (Unit:%) Example 1 Example 2 Example 3 Vitamins Immediately after sterilization Three months after sterilization Three months after sterilization Immediately after sterilization Three months after A 99.9 98.5 99.9 98.3 99 7.7 98.4 D 97.5 95.8 97.2 95.5 97.6 95.7 E 98.5 96.2--98.3 96.0 K 99.6 98.6--99. 8 98.5 B1 96.2 95.4 96.3 95.5 96.4 95.7 B2 98.8 96.4 98.7 96.7 99.0 97.4 B6 99.0 97.6 98 9.9 98.6 99.3 97.8 B12 98.3 96.1 --- 98.5 96.2 C 101.2 99.8 101.3 99.7 101.8 99.8 Nicotinic acid 99.7 98.9 99.6 98.7 99.5 98.7 Panthenol 99.9 99. 99.8 99.4 99.6 99.3 biotin 97.2 95.7 - - 97.5 95.9 folic acid 99.2 98.1 - - 99.0 97.9

[0065]

Table 3 (Unit:%) Example 4 Example 5 Vitamin Immediately After Sterilization 3 Months Immediately After Sterilization 3 Months A 99.8 98.6 99.7 98.3 D 97.6 95.7 97. 2 95.7 E 98.3 96.0 98.8 96.5 K 99.7 98.5 99.2 98.2 B1 96.3 95.3 96.5 95.1 95.1 B2 98.7 96.2 98.3 96.1 B6 99.2 97.5 99.3 97.2 B12 98.5 96.0 98.5 96.4 C 101.7 99.7 101.5 99.9 Nicotinic acid 99.8 98.7 99.4 98.5 Panthenol 99.8 99.3 99.6 99.2 Biotin 97.4 95.5 97.6 95.3 Folic acid 99.4 98.3 99.6 98.1

As shown in the results of Tables 2 and 3, a large number of vitamins were housed separately from the infusion component, and a large number of water-soluble vitamins were classified into those having a different stable pH range in a simple preparation. Soluble vitamins are classified into many water-soluble vitamins, and are separated and housed in each room in each ward.
With the H adjuster and the solubilizer, the pH in each compartment can be set to a storage condition that can stably maintain the vitamins contained in the compartments, whereby the stability of each vitamin could be secured. . In each of the examples, a vitamin-containing liquid containing vitamin B1 was stored in a compartment, and the pH was adjusted to be lower than the pH of the liquid contained in the other compartments and storage compartments, so that vitamin B1 was reliably and stably stored. I was able to. In addition, the stable p of vitamin B1 in the blended vitamins
Since H was the lowest, by containing it in the compartment, the sugar-containing solution could be kept at pH 4.5 or 5, and there was no need to use a large amount of a pH adjuster in the sugar-containing solution. Even when the pH was 4.5 or 5, no deterioration in the quality of the sugar-containing liquid was confirmed. In addition, since vitamin D was stored in the compartment, the amount of vitamin D adsorbed on the inner wall surface of the container was small, and the decrease in vitamin D was small. Example 2
Then, the pH of the vitamin-containing liquid contained in all compartments
Was made different from the pH of the infusion in the storage chambers 3 and 5, so that the stability could be ensured even if vitamins whose pH of the infusion was in a stable pH range were stored in a state mixed with the infusion.

In the examples, when the infusion containers after 3 months were visually observed, no separation was observed in any of the vitamin-containing solution, the sugar-containing solution and the amino acid-containing solution in any of the infusion containers, and a uniform solution was obtained. The liquid state could be maintained. This is because fat-soluble vitamins A, D, E, and K were separated from many water-soluble vitamins and stored in compartments.
This shows that the effect of modifying the interface of the solubilizer attached to the fat-soluble vitamin could be maintained.

[0068]

As described above in detail, according to the medical container with contents of the present invention, the container in which the infusion solution is accommodated in the accommodation room is provided with a partition portion which can be communicated with the accommodation room so as to be liquid-tight with the accommodation room. Since there are a plurality of compartments that are partitioned and smaller than the accommodation room, and a plurality of vitamins are accommodated in the plurality of compartments so that at least some of the vitamins and other vitamins are isolated, the infusion and the infusion The mixing operation with a plurality of vitamins for blending into is easy, and the plurality of vitamins can be stably maintained and stored for a long period of time, and unnecessary components other than drugs essential for a living body can be reduced as much as possible. An infusion container that is easy to manufacture is obtained. Further, according to the multi-chamber container of the present invention, in a multi-chamber container made of synthetic resin having a sealed accommodation chamber, a plurality of isolation portions composed of a non-peelable strong seal and a peelable weak seal continuous from the isolation portion are provided. A plurality of compartments smaller than the storage room are liquid-tightly partitioned from the storage room by the partition portion, and at least a part of the plurality of isolation portions is oriented to one side to arrange the partition portion. Thus, a multi-chamber container which can be suitably used for a medical container containing contents containing the above vitamin is obtained.

[Brief description of the drawings]

FIG. 1 shows an infusion container according to one embodiment of the present invention, wherein (a)
Is a front view, (b) is a vertical sectional view, and (c) is a horizontal sectional view.

FIG. 2 shows an infusion container according to another embodiment of the present invention (a).
Is a front view, and (b) is a longitudinal sectional view.

FIG. 3 shows an infusion container according to another embodiment of the present invention (a).
Is a front view, and (b) is a longitudinal sectional view.

FIG. 4 shows an infusion container according to another embodiment of the present invention;
(A) is a front view, (b) is a vertical sectional view, and (c) is a horizontal sectional view.

FIG. 5 is a front view showing an infusion container according to still another embodiment of the present invention.

6 is a longitudinal sectional view of the infusion container of FIG.

[Explanation of symbols]

 1 Container main body 3, 5 Storage chamber 7 Lower end 8 Upper end 9 Discharge port 10 Mixed injection port 11a, 11b, 11c Separation section 13a Storage chamber partition section 13b, 13c, 13d Partition section 15a, 15b, 15c, 15d ... Compartment

Claims (20)

[Claims] 1. A container containing a chemical solution containing one or more selected from the group consisting of amino acids, sugars, fats, and electrolytes in a storage chamber, comprising a partition part capable of communicating with the storage chamber. A plurality of compartments which are partitioned from the accommodation room in a liquid-tight manner and are smaller than the accommodation room; A medical container containing an article contained therein. 2. A water-soluble vitamin and a fat-soluble vitamin are separately housed in the plurality of compartments.
A medical container containing a container as described in the item. 3. The container-containing medical container according to claim 1, wherein at least a part of a plurality of vitamins having a different stable pH range in the single preparation is separately stored in the plurality of compartments. 4. The container-containing medical container according to claim 1, wherein the vitamin is an aqueous vitamin-containing liquid, and the vitamin-containing liquids having different pHs are stored in different compartments. 5. The medical container with contents according to claim 1, wherein the pH of the vitamin-containing liquid stored in at least a part of the compartments is different from the pH of the infusion in the storage chamber. 6. A vitamin-containing liquid containing vitamin B1 is contained in any one of the plurality of compartments, and the pH of the vitamin-containing solution is higher than the pH of the liquid contained in the other compartments and the compartment. The medical container containing contents according to any one of claims 1 to 5, which is prepared at a low level. 7. A vitamin-containing liquid containing folic acid is contained in any one of the plurality of compartments, and the pH of the vitamin-containing liquid is adjusted to the pH of the liquid contained in the other compartments and the compartment.
The medical container with a container according to any one of claims 1 to 6, which is prepared to be higher. 8. The container-containing medical container according to claim 1, wherein a vitamin-containing liquid containing vitamin D is stored in any one of the plurality of compartments. 9. The medical container containing contents according to claim 1, wherein a vitamin-containing liquid containing vitamin C is stored in any one of the plurality of compartments. 10. A multi-chamber container made of synthetic resin having a sealed accommodation chamber, comprising: a plurality of isolation portions formed of a non-peelable strong seal; and a partition portion formed of a peelable weak seal continuous from the isolation portion. Thereby, the storage chamber is liquid-tightly partitioned and has a plurality of partition chambers smaller than the storage chamber, and at least some of the plurality of isolation units are oriented to one side, and at least one of the A multi-chamber container, wherein the partition is disposed. 11. The medical container according to claim 9, further comprising an outlet at the one end. 12. The multi-chamber container according to claim 10, wherein the capacity of the compartment is 1/10 or less of the capacity of the storage chamber. 13. The multi-chamber container according to claim 10, 11 or 12, wherein the plurality of compartments are arranged adjacent to each other via the isolation portion. 14. The multi-chamber container according to claim 10, wherein the partition portion is continuous between both side portions of the container. 15. The multi-chamber container according to claim 10, wherein an upper end of the container is sealed by a non-peelable strong seal, and an upper end of the compartment is sealed by the strong seal. 16. The other end of the compartment is sealed by a partition made of a peelable weak seal.
16. The double-chamber container according to any one of items 15 to 15. 17. The multi-chamber container according to claim 10, wherein said storage room includes a first storage room and a second storage room partitioned by a communication-possible storage room partition portion. 18. The partition part and the storage chamber partition part,
Claim that is formed in a continuous straight line between both sides
Item 18. The double-chamber container according to any one of Items 10 to 17. 19. The medical container has a first divided container and a second divided container, the first divided container includes the plurality of compartments, and the first divided container has a plurality of compartments. A first partition part that liquid-tightly separates one end side and a first aseptic connection part formed on one end side from the first partition part, and a second divided container, A second partition provided with the storage chamber and partitioning one end of the second divided container in a liquid-tight and peelable manner; A first container and a second container which are joined by liquid-tightly connecting the first aseptic joint and the second aseptic joint. Item 20. The double-chamber container according to any one of Items 10 to 18. 20. The first divided container and the second divided container are liquid-tightly joined by a joining member.
20. The multi-chamber container according to any one of claims 19 to 19. 3.15