JP2002187812A - Cosmetic composition containing horse placenta extract - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition capable of bringing the skin and the hair to be biologically healthy and finishing the skin, improved in penetrability and effects of effective ingredients (a beautifying ingredient and a hair growing ingredient) and capable of maintaining a long term stability mutually given by each of the ingredients. SOLUTION: This cosmetic composition is prepared by using both an extract of horse placenta which expresses biologically sound effects to the skin and hair, and a beautifying and bleaching agent or a hair growing agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic composition which is excellent in producing vivid and healthy skin cells and whitening effect on skin, and excellent in maintaining and regenerating healthy hair on hair. To provide. In other words, for the skin, showing a sufficient moisturizing effect and whitening effect, dryness, rough skin, cracks, reddish dandruff, dandruff, Kayumi, inflammatory diseases, spots, prevent pigmentation such as freckles, reduce, or improve,
In addition, the present invention relates to a cosmetic composition that effectively acts on hair such as dry pricks, split ends, cut hair, gloss imparting, hair growth promotion, and prevention of hair loss by drying.

[0002]

2. Description of the Related Art Human skin and hair have a moderate level of moisture retention when they are in a healthy state and usually do not require special care. , Physical friction, dirty air, light, contact with water, etc.)
It may often cause changes and hindrance due to contact with detergents or aging.

[0003] That is, the skin or hair having a reduced moisturizing function is dry, hard, loses its luster and elasticity, and becomes crumpled. In recent years, it has been pointed out that such dry skin is related to atopic dermatitis, which is rapidly increasing.
It may cause various skin troubles. In addition, troubles such as loss of gloss, split ends, and cut hairs occur even in hair.

[0004] It is considered that the progress of these causes serious conditions such as pigmentation of spots and freckles, rough skin, wrinkles, and hair loss.

[0005] Conventionally, glycerin, propylene glycol, 1,3-butylene glycol, other polyhydric alcohols, oil and fat components, amino acids, proteins, polysaccharides, etc. Mucopolysaccharides and the like have been used.

[0006] The purpose found in these is to form a film by applying it to the skin or hair, to prevent the evaporation of moisture, and to devise a natural moisturizing factor: a component of the stratum corneum called NMF (Natural Moisturizing Factar). It was.

[0007]

In the conventional moisturizing component,
It was not yet satisfactory in terms of feel, durability of moisturizing effect, safety, and physicochemical stability.
In particular, the moisturizing effect was temporary and was not sufficient in terms of maintaining or regenerating physiologically healthy skin or hair, such as prevention or improvement of rough skin, hair loss, and split ends.

Accordingly, the present inventors have started the development of an active ingredient which exhibits a physiologically healthy effect and a skin conditioning effect on the skin and hair, and as a result of intensive research, have found that a horse placenta extract is extremely useful. As a result of further application research,
Heretofore, it has been found that when used in combination with a component having a whitening or hair growth effect, specific and many excellent beneficial effects are exhibited.

[0009] That is, by improving the skin to a physiologically healthy state, the permeability of the whitening component and the hair growth component is increased, and the skin more effectively acts on the skin. The present inventors have found that the cosmetic effect is maintained over a long period of time, and completed the present invention.

[0010]

The object of the present invention is achieved by providing a cosmetic composition essentially containing a horse placenta extract and a whitening component or a hair growth component.

[0011] In the present invention, the phylum Chordata, Mammalia, Equinoides (Epidoptera), Equid, Equus caballus (domestic)
Using the placenta. Horses are useful as livestock and breeding is progressing, and American miniature horses, Arabs, Argentine miniature horses, willish ponies, willish mountain ponies, garage horses, kiso horses, quarter horses, thoroughbreds, sara, Shetland pony, Tsushima horse (Tsushima horse), Tokala horse, Hokkaido horse (Hokkaido Japanese), Noma horse, Hackney pony, Falabella pony, Breton type, Paint horse type, Percheron, Pony, Midget pony, Miniature horse, Morgan , Yonaguni horse or any of these hybrids.

The active ingredient is extracted from the horse placenta using a suitable solvent. The horse placenta may be subjected to blood removal, treatment such as freezing, thawing or heating for aseptic purposes, or removal of oil-soluble components for removing hormones.
The solvent used for removing the hormone may be butanol, hexane, acetone, or the like.

The extraction solvent may be water, physiological saline, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol and ethanol, or propylene glycol,
Polyhydric alcohols such as 1,3-butylene glycol) or ketones such as acetone, ethyl ether, dioxane,
Esters such as acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or as a mixture of two or more kinds. After the extraction, the extract is filtered and sterilized as necessary, or the extract is diluted, concentrated and dried.

The production method is usually carried out in the range of the boiling point of the solvent from normal temperature to normal pressure, and after extraction, filtration and, if necessary, adsorption, decolorization and purification using an ion exchange resin, etc. , Paste, gel, powder.

The horse placenta extract thus obtained can be used as it is in many cases. However, if necessary, a purified treatment such as deodorization and decolorization can be carried out using an activated carbon column or the like. good.

The whitening component or hair-growing component in the present invention includes many active substances, which are already known for their use in cosmetics, components extracted from plants or animals, and active components utilizing microorganisms and biotechnology. means. Among these, as an extractable component from plants or animals, mainly water, ethanol, propylene glycol,
An extract obtained by using 1,3-butylene glycol or an arbitrary mixture thereof as a solvent at room temperature to the boiling point of the solvent, or a concentrate or dried product thereof can be suitably used.

All of these are available as industrial commercial products. For example, when the raw material is a plant, it can be easily extracted and manufactured. In addition, as a usable site | part, whole plants may be used other than using a medicinal site | part, such as a flower, a seed, a leaf, a stem, a root, a bark, or an above-ground part, respectively.

As typical whitening components, especially kojic acid,
Arbutin, ascorbic acid or a salt thereof, ascorbic acid phosphate or a magnesium salt thereof, ascorbic acid glucoside, ellagic acid, lucinol, sodium lactate, Achillea millefolium extract component, Kawataya extract, Fujibakama extract component, Mulberry extract component, Artemisia extract component , Extract of pentagon, water-soluble silk protein hydrolyzate, extract of aloe, extract of peanut, extract of saxifrage, extract of kumazasa, extract of licorice, N-acetyltyrosine or its salt, glutathione, tannin, quercetin, fermented metabolite of lactic acid bacteria Etc. can be used.

Examples of the hair-growing components include capronium chloride, cepharanthin, nicotinamide, benzyl nicotinate, vitamin E acetate, pantothenyl alcohol, biotin, glyceride pentadecanoate, an extract component of Hypericum perforatum, l-menthol, minoxidil, and canthari tincture. Can be used, such as tincture, pepper tincture, Clara extract component, assembly extract component, Korean ginseng extract component, ginseng extract component, buttonpig extract component, lime extract extract component, calendula extract component, arnica extract component, hop extract component, etc. .

In the cosmetic composition according to the present invention, the horse placenta extract is used in a concentration range of 0.0001 to 10% by weight (preferably 0.001 to 5% by weight) as a solid content. In the case of an extract, it is used in this solid conversion amount.

In the cosmetic composition according to the present invention, it is desirable that the whitening component or the hair-growing component is appropriately contained in the range of the known or recommended effective concentration of each component. 0.
Desirably, the content is in the range of 0001 to 10% by weight.

The cosmetic composition according to the present invention includes 1) topical or systemic skin cleansing or skin cosmetics, 2) medicinal and / or cosmetic preparations applied to the scalp and hair, 3) baths Bath agent used in hot water, 4) Deodorant and deodorant for human body, 5) Skin sticking sheet, cosmetic sheet, cosmetic cotton, sanitary goods, sanitary cotton, wet tissue, etc., ampule , Capsules, powders (powder), granules, solids, solutions, gels, air bubbles, emulsions, sheets, mist, sprays and the like can be used.

Specifically, basic cosmetics such as lotion, milky lotion, cream, ointment, gel, lotion, oil, pack, mist, facial cosmetic sheet, shaving agent, facial cleanser, skin cleanser, Hair cosmetics such as shampoos, rinses, hair treatments, hair styling products, perming agents, hair tonics, hair dyes, hair growth and hair restoration, makeup cosmetics such as foundations, lipsticks, blushers, eye shadows, eyeliners, mascaras, and perfumes Kind, skin deodorant,
Antiperspirants, bath additives, etc. are included.

In the cosmetic composition of the present invention, in addition to the above-mentioned essential components, if necessary, any of the components and additives exemplified below may be arbitrarily selected and added as long as the effects of the present invention are not impaired. Can be.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oils Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters: isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its esters, trehalose or its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or alkylene such as chitosan, ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decoloration, etc. Can be selected for use.

The solvent to be used for the extraction may be appropriately selected in consideration of the purpose and type of the product to be manufactured, or the processing to be performed later. Usually, water and a water-soluble organic solvent (for example, , Ethanol, propylene glycol, 1,3-butylene glycol, etc.)
It is desirable to use a species or a mixture of two or more species. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and any mixture of water and water alone may be used. It may be something.

In addition, additives derived from plant or animal raw materials are
When used for cosmetics for whole body or topical use, including protection of skin and hair, moisturizing, whitening, improving feel and texture, imparting flexibility, relieving irritation, relieving stress by fragrance,
Cell activation (prevention of cell aging), suppression of inflammation, suppression of allergy, improvement of skin and hair quality, prevention and improvement of rough skin, hair growth, hair growth, prevention of hair loss, gloss imparting, cleaning effect, relief of fatigue, blood In addition to cosmetic effects such as flow promotion and warm bath effects, addition or enhancement of effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

Specific plants (crude drugs) as raw materials include:
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsujirafuji (Kibo), Acacia, Akashoma (Akamasa), Akasuri `` fruit '', Red clover, Red grape, Akaminoki (Logwood), Red moss (Red bud), Red moss (Akane grass root), Red moss Ground yellow), Agi (Awei), Aki Larch, Akinire (Latinaceae),
Aguay Guacu, Aguahe (Omitengu palm),
Akebi (Kidori), Asa (John Asako), Malva Asagao or Asagao (Toshibushi), Hydrangea (hydrangea), Ashitaba (Ashitaba),
Azuki (red azuki), acerola, asenyaku (Asenyaku), acira (shokuyoukanna), anise, abiu, abiurana, rape, avemaki `` fruit '', avocado, ama, amacha (sweet tea), amachaworu, amadocoro (tamatake), Amana (Kikomiko), Amaranthus (Amaranthus), Amaranthus hippochondriacus, Haribiyu, Amaranthus hippochondriacus, Amigasa lily or Bimo (shellfish),
Aristolomelia (Yurizisen), Arcana (Alcanna), Algarrobo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Souduq), Aloe (Length), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azusa), Yellow sapote , Ikakozorina (ground bile head), Epimedium or Epimedium
(Inyokaku), Igusa (Wicked grass), Knotweed (Tiger root),
Strawberry (first place), strawberry, fig (Fig.
Leaf)), Ichihatsu (first time), Ichibi (Fruit Aoi), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimemegi (Enshi), Carob, Inu-zuna (Telelexi), Inubeyu (Sorainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwatsuchi-chi), iwahiba or iwamatsu (makikashiwa), oolong tea, wikyo (fenka), wheat (tibusanoki), ukiyagara (miyoko) ), Uguisukagura "fruit",
Himeuikyo, Turmeric (Utsukin), Duckweed (Floating), Usubasaishin or Keirinsaishin or Shousaisaishin (Spicy), Usvenia oi, Usvenitai oi, Utsubogusa (summer dry grass), Udo or Shishiudo (Qang, Independent, Tang Independent) ), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Ume `` seed, pulp ''), Urajirogashi, Uwaurushi (Kusakokomomo), Unshu mandarin (Chen skin), Estragon, Ezocogi (Ezogoka), Echinashi (Hosobamurasakikirengiku) , Enishida, Enokitake (Enotake), Ebisugusa or Cassia Tora (Kyoko), Elcampre, Elderberry `` fruit '', Elemi, Elingy or Prelotus elinge, Endu (Solanaceae, Sophoraceae rice), Ogi or Kibanaugi (yellow) Hoki), Ousei (Naruko lily, Kagi Kurumabanarukoyuri), OuHisasa Yuki or Sasanoyuki, Coptis (Coptis), Oogatahouken, giant Karasuuri (Karokon), Ooguruma (civil engineering incense), giant Tsudzurafuji
(Self defense), psyllium (vegetative child, vegetative grass), toucan hazel (haruko), toucan cactus, pygmy plant or okera
(White jujube), giant leaf sedge (banaba), giant leaf beetle "fruit", giant squirrel (grain sperm), giant caterpillar, giant hawthorn or hawthorn (yamashiko), barley
(Barley), oka, okazeri (snake bed), okra `` fruit '', ogulma (turnover), panax ginseng or ginseng (carrot), hypericum or hypericum perforatum or perforated periwinkle (brother cut grass), dragonfly (continuous cut), onamimi (blue) Ears), Onigurimi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasayuri or Hakatayuri (Yuri), Ononis, Halibut
(Hihayu), Ominaeshi (defeated), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch honeywort, olive "fruit, seed, leaf", oregano, orange "fruit, pericarp", silkworm (ripened yellow) , Cocoa "fruit, peel,
Seeds '', oysters (persimmons `` leaves ''), kagi kazura (crop hooks), oysters or kantosori (rensensou), gaku hydrangea, cassia, casino quids (mushrooms `` fruits ''), gajutsu (shadow jelly), Kashiwa
(Sakura tree, Sakuraha), Cascarilla, Cascara sagrada, Gypsophila, Kanixa (Kin Sato), Kaniwa, Carnation,
Valerian (valerian root), birch or weeping birch (white birch), gerbera, pumpkin, kapok tree `` seed '', kahoku sansho (shopper), gama (bamboo), chamomile or roman chamomile, chamomile (weed), camucum (duckling),
Color, Karaku Sakeman, Calla Uri or Chinese Calla Uri (Our Gourd), Callas Bishaku (Midsummer), Oat Wheat, Guarana `` Seeds '', Calla Oo (Pop), Karaya, Galyu, Karin
(Gourd melon), Garcinia, Kawamidori, Kawara Psycho (Koryosai, Hakubaku), Kawazusha, Kawaratake, Kawaranadeshiko (Ishitake) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaranginjin (Blue Gourd), Kawamuragi (Inchinchinko) , Kansui
(Sweet), licorice (licorice), cantaraasa, candelilla,
Kanto, Canna, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiroi strawberry, Mapi strawberry, European strawberry), Kiwi `` Fruits, leaves '', Kikarasuuri (Urorone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum, Shimakaniku, Artemisia japonica, Kikutanikiku, Catalpa (Azumitsu), Rigid ridge (Yotei root), Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachi mint, Kina, Kinoki (Shincona, Akakinoki), Quinoa (Kinoa),
Yellowfin, yellow sylvester, kimmenkaku, cabbage, cabbage "immature fruit", cucumber, gyoryu
(Nishikawayanagi, Ichiyanagi), Kiraja Saponaria, Kiraya, Kiranso (Kinen Koso), Kumquat `` fruit '', Ginkai,
Kimbusen, betel, golden hibiscus (Sesame crass), guapeba vermelha, guava `` fruit '', guayule, quelux infectria (gallicate), cucumber nuts,
Wolfberry (Gugi, gugi, gugi leaf, skeletal bark)
(Tenmen winter), Kudzu (Kakkon), camphor tree, gooseberry `` fruit '', Ginseng (yellow flower), Kutiti River, Gardenia (Gardenia), Kunugi (Bokuso), Kupuas, Kumazasa,
Black pine (horse whip grass), Clara (bitter butter), cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curculigo latifolia `` fruit '', grapefruit `` fruit / leaf '', buckthorn, black squirrel (rescue), Kurobana Hikiokoshi Or Hikiokoshi (extended lifegrass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi), kaigai (infestation, infestation), celosia (corolla, rooster), gekkavidin, bayberry (laurel), kenashisarutoribara (soil) (Bukuryo, mountain return), gentian, genoshoko (old treasured grass), kenponashi (kigushi), koukisekoku, kishumikan (kouji, tachibana, ovenimikan, fukuremican, sagamikouji, ponkan, santara (tachibana)), koshinbara (monthly flower) , Kosui mint, Kozo "fruit", Kocha (tea), Kouhone (river bone), Koho (Straw and Kara straw), Koryang, Kouryokyo (Korakyo), Cilantro `` fruit '', Kourouen (Kohren), Koganebana (yellow gon), bilberry (Koshibachi), coconut `` fruit '',
Goshuyu (goshuyu), Goshoichigo (covered bonko), pepper
(Pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock,
Burdock), kobotdur, sesame (sesame), sesame seeds (gensin), garnish (gomiko), sanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata " Seeds ", cola
Vera “seed”, colony lya, fenugreek “fruit”, colombo, conzlango, kelp, konjac, comfrey
(Final barn grass), sisal (sisal asa), saxima button or syna button or cinnamon
Sakura (Ooshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Yoshino cherry tree, Takanezakura, Kasumizakura, Chojizakura,
Kohigan, Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranates, sasa, sasanqua,
Sage Modaka (Sawaka), Sweet Potato, Sugarcane, Sugar Beet, Sunabet Jujube (Satsumitsu Jin), Saffron (Safflower, West Safflower), Sapodilla, Sapotea Marillo, Pomelo "Fruit", Sabonsou, Salmon Berry "Fruit", Sarasinoshima (Masuma) , Salvia (sage), Sawagyoukyo (Sancho-na), Sawagumi (Sanguo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin carrot (San carrot), Sanshuyu (sanshuyu), Sanshoyu (sanshoyu) ), Sandscon (Yamazone), Shea (Carite), Cyano (fruit), Shiitake (Shitake), Shion (Shion), Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimendiso or Katamenziso (Perilla leaves, Perilla) ), Rosewood, linden, Chinese pine, Chinese forsythia, shimeji
(Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiroishimeji, Bunashimeji, Honjimeshi, Shirotamogitake),
Shimokure (Spirit), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Jasmine (Matsurika), Janohige (Motomon winter), Scutellaria paniculata, Skushamitsu (sand sand, shrinking sand), Juzudama, Shiro Fruits, ginger (ginger), ginseng hydrangea (Tsuneyama), shobu (irises, iris roots), shojiku (fruits), shirakashi (seed), shirogoshi butterfly (seed), white clover (clover), white adzuki (chicken bone grass), Shirobanairisu (Small iris), Shirobanatsuta "flower", Shirominanten (Minami Tenmi), Cinchonasakusylbra, Jingouge (Mizuka, Mizuka, Sinking flower), Cinnamon, Cinnammum cassia (Glass bark), Watermelon (watermelon), Honeysuckle (Gold and silver) Flowers, Shinobi winter),
Sorrel (acid model), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), horsetail (infestation), purslane (horse dent, horse dent), plum `` fruit '', pear Pinus densiflora, larch, vegetation, walnut, walnut, hawthorn, dandelion, horse chestnut
(Marronnier), pear `` fruits '', snowy pears, yellow pear (elder), northern pears (juniper, juniper), yellow pear (millfoil), yellow pear, rose, yellow mistletoe, yellow lipstick or yellow pear
Horseradish, Sekisho (Iris), Sekkoku (Ishimasu), Cedron (Bowshukuboku), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Sengoku (Kawakyu), Sengshinren (Shinshinren), Sengdan, Senninsaboten, Senna , Leaves '', Senninsou (great tate), Japanese cabbage (medicine), squid (grass), elephant, buckwheat `` seed '', Somei potato, rhubarb (daihuang), radish, soybean, daidai (orange peel, kimi), Takasaburo ( Drengsou), Takatodai (Daigei), Takawarabi (Inu spine), Dark sweet cherry "fruit", Tachioi, Tachijakoso (thyme,
(Marika), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` seed '', onion, tamshiba (spicy), Taranoki `` fruit, leaf, root bark '', dahlia (tenjikubotan), tarwi,
Tanshiniwa, Tanjin (Dan ginseng), Dandelion (Gankoei) or Shirobana dandelion or Moko dandelion, Danmar, Cherry `` fruit '', Tigaya `` fruit, root, bud '', Chixet carrot (Bamboo ginseng), Chicory, Chancapiedra (Kidachiko Mikansou) , Datura (Rhuanghuang), Datura elm (Wuyi), Datura mugwort (Aiba), Choreimaitake (Irei), Chorogi, Tsukimisou, Tsukuritake (mushroom), Camellia, Camellia, Tsumekusa (lacquer primrose), Camellia Ducklings), Tsuruazuki (red azuki bean), Tsurukudami
(Hanshu crow), Tsuruna (Ban apricot), Crucian carrot (Four leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tulip, Chocolate stay, Tengusa, Tencha (Tencha), Tendaiyaku (Wood medicine), Touga (Winter ginger) ), Squash, capsicum (pepper), squid (return), calendula (marigold), tonabena (river cut), corn or corn hair (southern hair), horned beetle (female child), torindo or kosen Gentian,
Tokusa (wood pirates), dokudami (jujutsu), konkon (sore root), sashimi or mamedaoshi or scutellaria, eucommia (mushroom `` bark, leaves, roots ''), ash (qin bark), tomato, tragacanth, triacanthos `` seed '', Turkey Kikyo, Tormentilla, Dronoki, Troloa oy, Niseria berry "fruit", Chinese yam or Yamanoimo (Yamayaku),
(Butcher Bloom), Naginata Kouju, Nazuna, Rape, Natsume Bean or Hatehaki (Sword Bean), Natsumikan, Jujube (Daijutsu), Naniwaibara (Kanakurako), Navena (intermittent), Nameko, Narco Lily (Yoshimi), Peanut (Peanut) ), Nanten (Minami Tenmi), Namban Karamushi (ramie), Niois violet,
Nigaki (bitter tree), bitter mugwort (bitter mite), nutmeg, kei or nikkei or ceylon nikkei or yabnikkei (cinnamon bark)
Or Keishi (Keishi), Chinese chive (Nirako), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nulde (fivefold child), leek, nemoki or neb or nebi or nemlinoki or zigokubana ( Healing), Noa thistle (Ohi), Noibara (real fruit), Yarrow, Nodake (Maehu), Nobara, Nomomo,
Pineapple `` fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hyalindo, Hauchiwa, Pau Dosse, Hakayamauraboshi (Bone Crusher), Hachsen
(Ringworm skin), huckleberry `` fruit '', chickweed (reddish), hazel (haruko), hasiridokoro (roth root), basil, lotus
(Lotus, lotus meat, Renko), parsley (Netherland jelly), naked mussels, batata, bees or medakes (bamboo boiled), patchouli, mint (lightly-loaded, lightly-leaved leaves), adlay (yokuninin), hanasuge
(Chimo), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanillabins, Papaya, Scotch (Rice koji), Pahalobobo, Hub `` Whole grass, stem, leaf '', paprika,
Hamago or Mitsuba Hamago (vine thorns), Hamazuge (Katsuki), Hamabishi (Situriko), Hamanas (maikai flower), Hamabou (beach storm), Hamamelis, palm, rose (rose), balata, balata rubber tree, agaric (haratake,
White agaricus, Usukimori no kasa), Haran, Paliurus (Pleurotus japonicus), Parietaria, Balsamina (Tsurureishi, Nigauri), Harunile (Yellow, Yu white skin, Yuba), Barbasco, Harindou, Handaikai
(Gangtai Sea), Breadfruit, Hiogi (Ranker), Lycopodium ginseng (Party), Pecan Nut, Giganbana (Shirubi, Jinjusha Hana), Higul Madaria, Hishi (Ryomi), Pistachio, Beet, Hitotsuba (Ishire) , Aedes fern, daisies
(Daisy), Hinata Kozuchi (cow knee), Hinoki, Hiba,
Castor, Sunflower, Bell Pepper, Himeuzu (Tenoi), Himegama (Kaba), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta `` Fruit '', Juniper, Bjakuyu, Hiyu `` Fruit '', Beroudooi, Hirohiro Okinagusa (Hakutooka), Loquat Fruits, leaves, stems '', betel wax (large clothing skin, betel nut), puerh tea (Pulse tea), sprout kazura (southern rattan), butterbur, butterflies (winter flowers, winter leaves), fujibakama (orchid grass), wisteria beans (flat beans) ), Grape "fruit, peel, seeds,
Leaf '', beech, sycamore mushroom (Cycanoderma), Brazilian liquorice, Brazilian carrot, black currant `` fruit '', blackberry, blagnen, plum `` fruit '', flucellaria, blueberry (Prunus avium), prune, floral blanka, Blonde psyllium, bundou (mung beans), hazelnut, loofah, safflower (safflower), henneken, belladonna, berry `` fruit '',
Persea, Perbianberg, Pereschia grandifolia, Benikea or duckweed (Keiten), Boysenberry `` fruit '', Broomweed or Elderweed or Nendow or Hawakigi Kokia (Skinkoshi), Baldwink (Fengxian, acute child, osteophyte) , Potteria sapota, Potteria lukuma, spinach, boufu (windbreak), spinach, physalis (Torone), honoki (wakopoku, park), bokeh (gourd), hosovanaokera (blue jitsu), hosobanokirinsou (Keitensan) (7), hosobarabaengiku, bodaiju (bodhi tree), button (peony `` flower, leaf, stem, bark ''), buttonpi (peony skin), hop,
Jojoba, Borigi (Ruriichisha), Bordeaux, Whittle berry `` fruit '', Hong Onik (meat porcelain, large art), Hong Sekkok (iron bark mackerel, sparrow mountain stone mascara), misurutennanshaw
(Tennan star), Maitake (Maitake), Ephedra (Maohu), Maca, Macadamia nut, Margaret (Mokshungiku), Macri
(Sea grass), Magwa (mulberry white bark `` bark, leaves ''), magnolia
Splengheli, Masaranpouba, Masaranzuba do
Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matabi (Mokuten Tate), Matsukasa, Pine `` leaves, bark, roots '', Matta Olho, Matsuhodo (Bukuryo), Matico (Cordon Sillo) ), Mayorum (Hanamint), Malvanojazine (Bitterfruit), Mulberry `` Fruit '', Quince, Malein (Beloyd Mozambique), Mango, Mangosteen, Mansagna (Andesca Mitsure), Mansu Gurumi, Mandarin `` Fruit '',
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokukushi (Hanbe Lotus), Misohagi (Chisatsuna), Mizunyanagi or Shiroyanagi (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle Fruit `` Fruit '', Myrrh, Milobalan, Wheatwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (extended skin), Munya, purple (purple root), purple or purple purple
(Purple beads), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, red seaweed (mother grass), red seaweed, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), mock berry (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), sprouts, morello cherry `` fruits '', Moroheiya (Burlap), yakawamurasakiimo, yakuchi (masuchi), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow wheel) or himeyashabushi or ophayashabushi `` fruit,
`` Peel, ears '', willows, yatsude (octagonal gilded), mistletoe (parasitic willow), willows (kawayanagi, tachiyanagi, weeping willow, red willow, pussy willow, dogwood willow,
(Sweet willow, koreanagi, unryuyanagi, yamayamayanagi, palm, yamayanagi, giant psyllium, tyrichkinuyanagi, foxwillow, bonsai), willow `` leaf,
Stalk '', scabbard, savannah koji (purple beef),
(Tsurusu, Tenmei), pokeweed (land), yamanoki (mountain harbor), yamamomo (yangmei), sagebrush, eucalyptus, yukinosita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, yorigusa , Mugwort (Aiba), reigan (Rainuma), lime "fruit", rye, lakanka "fruit",
Raspberry `` leaves, fruits '', Latania (Clameria), Rakkyo or shallots (Shiroi), lavender, longan (longan meat), agave (Aono agave,
Fukurin agave), Ryokucha (green tea), apple `` fruit, seeds, leaves, roots '', gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', Red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, coconut palm, locust (reed, azuki), loganberry `` fruit '', rosemary (mannen wax), rosehip (nobara), wasabi, Waremokou (chiyu) and the like.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaa nori, Susiaonori, Hiraaonori, Bowa nori, Hosoedao aonori), Anaausa algae [Aosa algae] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], seaweed [Red algae: Hijirimen, Maxa (Tengusa), Hiracusa, Oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonoji, Kotobino, Kotobino , Hyus banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas spp .: Chlamydomonas spp., Akayukimo, Dunaliella spp .: Dunaliella spp. Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;

Blue-green algae (Genus Lynchium: L., L., L., L .;
(Hassay, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiakashio), etc.).

Brown algae (Piraella spp .: Piraella spp., Pleurotus spp.
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russula genus: Bovine genus, Funorinoshike, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikenori: Fushikenori, Namiiwatake: Namiiwatake, Scorpionae:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashi Genus: Isobashi, Fujimatsumo: Fujimatsumo, Sawweed: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, chinorimo: chinorimo, tysinori genus: chisinori).

The axle algae (Charus spider, Shiratamamo,
Hossiturimo: Hossiturimo, Lychnotanus genus, Flassica genus: Himejirasamo, Chaboflasmodium, Tripera genus, etc., Yellow algae (Hikarimo genus: Hikarimo etc.) and the like.

Materials derived from animal raw materials include a cockscomb extract, a pig placenta extract, a pig stomach, a duodenum, or an intestinal extract or a decomposition product thereof, a pig spleen extract or a decomposition product thereof, Pig brain tissue extract, water-soluble collagen,
Collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its degradation products or their derivatives, silk proteins and their degradation products or their derivatives, pig or bovine blood Glycoprotein (globin peptide),
Pig or bovine hemoglobin degradation products (hemin, hematin, heme, protohem, heme iron, etc.), milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken eggs Ingredients, decomposed fish meat, etc.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, Euglena extract or its decomposition product or Such water-soluble derivatives, lactic acid fermented products of raw milk or skim milk powder, trehalose or derivatives thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigment: anhydrous silicic acid, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono
Glyceryl-2-ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Action of promoting turnover / cell activator hydroquinone, lactic acid bacteria extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe,
Ogon, Japanese horsetail, Gentian, Burdock, Sikon, Carrot, Hamamelis, Hop, Yokuinin, Odorikosou, Assembly, Touki, Tokinsenka, Amacha, Hypericum, Cucumber, Tachikoso, Rosemary, Parsley), etc.

(19) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(20) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(21) Antioxidant stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA),
Hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(22) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Tenmi,
Ages, ginkgo, green tea).

(23) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(24) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, chloro Butanol, isopropylmethylphenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Lenoctyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethyl ammonium bromide, benzalkonium chloride, benzethonium chloride, methyl rosaniline chloride), Formaldehyde, hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(25) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin derivative or chitosan derivative, pyrrolidone carboxylic acid or its salt, Sodium lactate, mini Sasanishiki extract, Bacillus natto metabolite, natto extract, etc.

(26) Inhibitors of elastase activity Diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, Mulberry leaf, Cauliflower, Gennoshoko, Comfrey, Sage, Sambucus nigra, Bodaiju, Botanpi), seaweed extract and the like.

(27) Hair Agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(28) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(29) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(30) Stimulant Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(31) Metabolic activators Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placental extract, biotin, glyceride pentadecanoate and the like.

(32) Antiseborrheic agents pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(33) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(34) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(35) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(36) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(37) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonic acid sodium salt, hematein and the like.

(38) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shape essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(39) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(40) Marine components Seawater, for example, seawater salts, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (such as sodium chloride, magnesium chloride, and potassium chloride), sea mud or mud (fango) ), For example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, oxide Magnesium, calcium oxide, strontium oxide, sodium, potassium,
Magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Shotokuishi and so on.

(41) Others Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers,
Vegetable proteins and their degradation products, animal and vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow promoters, antiallergic agents, wound healing agents, foaming agents, thickeners ,
Enzymes, electronic water, small clustered water, and the like are raised, and when used in combination to form a cosmetic composition, an additive or synergistic improvement in the effects of the present invention or other cosmetic effects can be expected.

[0076]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these.

[0077]

[Example 1] [Example 1] Production example of horse placenta extract Healthy horse placenta (10 kg) was crushed, blood was removed, and then n-butanol (4 to 5 kg) and purified water (10 to 50 kg). And aseptically extract. Next, the n-butanol layer was removed, and the collected purified water layer was concentrated under reduced pressure to completely remove the remaining n-butanol to obtain a placenta extract (solids concentration: 0.8 to 2.5%).

[0078]

[Example 2] Production example of horse placenta extract Fresh healthy horse placenta (10 kg) is aseptically frozen and thawed several times. After washing with water, it was crushed and blood was removed. Then, a 0.9% sodium chloride solution (10 to 50 kg) was added, and the mixture was stirred and extracted at a low temperature. The supernatant was taken, ammonium sulfate was added at a low temperature, and the mixture was left to stand. The precipitate was dissolved again in purified water (5 kg), dialyzed, purified water (5 kg) and 1,3-butylene glycol or ethanol (30% amount) were added, and sterile filtration was performed.
(Solids concentration 0.8-1.8%).

[0079]

Example Production of an extract component of Achillea millefolium Linne (C
water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof, or 1% urea-containing ethanol solution, 1% urea-containing 1,3-butylene A glycol solution was added, immersed and extracted at room temperature to 60 ° C., and filtered to obtain an extract component of Achillea millefolium containing tannin.

[0080]

[Example] Production of an extract component of Artemisia capillaris Thunb. (Composite)
ae)) water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the head flower or the above-ground part or the whole plant, and the mixture is extracted at room temperature to 60 ° C., and filtered to remove flavonoids. An extract component of the Japanese sagebrush was obtained.

[0081]

[Example] Production of Fujibacama extract component Fujibacama (Eupatorium fortunei Turcz.
e)) Water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the foliage, above-ground part or whole plant of e)), extracted at normal temperature to 60 ° C., filtered, and filtered to extract Fujibakama I got

[0082]

[Example] Production of mulberry extract component Mawwort (Morus alba Linne) or other congener plant (Morac)
water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the root bark or leaves of eae), extracted at room temperature to 60 ° C., filtered, and contains triterpenoids and flavonoids A mulberry extract was obtained.

[0083]

EXAMPLES Production of Artemisia Extract Components Artemisia princeps Pampanini (Composita
e)), Artemisia mongolia Fischer (Com
positae)) or Artemisia montanaPampa
nini (Compositae)) leaves, or whole plants with water, ethanol,
Add propylene glycol, 1,3-butylene glycol or any mixture thereof, and extract at room temperature to 60 ° C.
Filtration yielded a mugwort extract containing coumarin derivatives and flavonoids.

[0084]

[Example] Production of extract of Japanese gougon (Scutellaria baicalensis Georgi (Labiata)
e)) Water, ethanol, propylene glycol, 1,3-butylene glycol or an arbitrary mixture thereof is added to the roots or roots excluding the pericytes, and extracted at room temperature to 60 ° C., and filtered to extract baicalin or A gougin extract component containing baicalein, gougonin and tannin was obtained.

[0085]

EXAMPLES Production of Aloe Extract Components Aloe ferox Miller or Aloe africana Miller
Or hybrid with Aloe spicata Baker (Liliaceae), or Al
oe barbadensis Miller (Aloe vera Linne), or Aloe arborescens Miller and its variants (Lilia
ceae) leaves, leaf sap, water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added, extracted at room temperature to 60 ° C., and filtered to obtain an aloe extract. .

[0086]

[Example] Production of buttonpi extract component Button (Paeonia suffruticosa Andrews (Paeonia mouta)
n Sims) (Paeoniaceae)), add water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof, extract at room temperature to 60 ° C, and filter to remove paeonol and paeoniflorin. A contained peanut extract component was obtained.

[0087]

EXAMPLES Production of Saxifrage Extract Components Saxifrage stolonifera Meerburg (Saxifra
gaceae)), water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the foliage or whole plant, extracted at room temperature to 60 ° C., filtered, and filtered to extract a tannin-containing saxifrage. The components were obtained.

[0088]

Example Production of Kumazasa Extract Components Water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof was added to leaves of Kumazasa (Sasa veitchii (Carr.) Rehd. (Gramineae)), Extracted at 乃至 60 ° C. and filtered to obtain a terpenoid-containing Kumazasa extract.

[0089]

EXAMPLES Production of Licorice Extract Components Licorice (Glycyrrhiza glabra Linne or Glycyrrhiza ur)
alensis Fisher (Leguminosae)) or other congeneric plants (Le
water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the roots or rhizomes of guminosae), extracted at room temperature to 60 ° C., filtered and filtered to remove glycyrrhizic acid or a salt thereof, flavonoids. A contained licorice extract component was obtained.

[0090]

EXAMPLES Production of Hypericum extract component Hypericum perforatum Linne (G
uttiferae)) or Hypericum (Hypericum erectum Th)
unberg (Guttiferae)) or water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the above-ground part or whole plant, extracted at room temperature to 60 ° C, filtered, and flavonoids, tannin The extract component of Hypericum perforated was obtained.

[0091]

EXAMPLE Production of Clara Extract Components Clara (Sophora flavescens Aiton (Leguminosae)) without root or its perimeter, or whole plant with water, ethanol, propylene glycol, 1,3-butylene glycol or any of them The mixture was extracted at room temperature to 60 ° C. and filtered to obtain a flavonoid-containing Clara extract.

[0092]

[Example] Manufacture of Assembly Extract Components Assembly (Swertia japonica Makino (Gentianaceae))
Water, ethanol, propylene glycol, 1,3-butylene glycol or an arbitrary mixture thereof is added to the foliage or whole plant of the plant, extracted at room temperature to 60 ° C., filtered, and filtered to obtain a component extract of swertiamarin. I got

[0093]

[Example] Manufacture of Korean carrot extract component Korean carrot (Panax ginseng CAMeyer (Panax schins
eng Nees) (Araliaceae)), add water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof, extract at room temperature to 60 ° C, filter, and filter the saponin-containing Korea. A carrot extract was obtained.

[0094]

EXAMPLES Production of Extract of Ginseng Ginseng Ginseng (Panax japonicus CAMeyer (Aralia)
water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the rhizome of ceae)), extracted at room temperature to 60 ° C., filtered, and saponin-containing extract of ginseng ginseng I got

[0095]

[Example] Production of an extract component of Emmeso radishes
ponicus Nakai, Plectranthus japonicus (Burm.) Koidz
(Labiatae)) or black clover (Isodon trich)
ocarpus Kudo (Plectranthus trichocarpus Maxim.) (Lab
iatae)), water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the foliage or the above-ground part, extracted at room temperature to 60 ° C., filtered, and contains emmain and tannin The extract component of the extract of E. ginseng was obtained.

[0096]

EXAMPLES Production of Calendula officinalis extract component Calendula officinalis Linne (Compos
water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the head flower or foliage or whole plant of itae), extracted at room temperature to 60 ° C., and filtered to remove saponins and flavonoids. A contained calendula extract component was obtained.

[0097]

EXAMPLES Production of Arnica Extract Components Water, ethanol, propylene glycol, 1,3-butylene glycol or any mixture thereof is added to the flowers, foliage or whole plant of Arnica (Arnica montana Linne (Compositae)), and the mixture is cooled to room temperature. The extract was extracted at 乃至 60 ° C. and filtered to obtain an extract of arnica containing flavonoid and saponin.

[0098]

Example Production of Hop Extraction Components Water, ethanol, propylene glycol,
Add 1,3-butylene glycol or any mixture thereof, extract at room temperature to 60 ° C., filter and filter flavonoids,
A hop extract component containing tannin was obtained.

[0099]

Example 1 Moisturizing property of equine placenta extract 1 In order to evaluate the moisturizing property of the equine placental extract of the present invention, the change over time of the water content of the stratum corneum by a monitor was determined by measuring the electrical conductivity. . (Sample solution) Horse placenta extract of Production Examples 1 and 2 (adjusted to a solid content of 0.0001%) (Measurement device) IMPEDANCE METER SKICON-200; manufactured by IBS Corporation (Monitor) 22-year-old woman, 24-year-old woman, 29 (Test environment) 24 ° C, 50% RH (Method) One hour before the test, put the monitor in a constant temperature and humidity room adjusted to the test environment and stabilize it. afterwards,
Apply each sample solution (1 mL) to the forearm flexion side of the monitor,
After seconds, excess water is removed and the electrical conductivity of the stratum corneum is measured over time.

FIGS. 1 to 3 show the results. It was found that the equine placenta extract according to the present invention has a higher moisturizing effect and is maintained for a longer time than the aloe vera extract having the same solid content (comparative example). It was also confirmed that a synergistic effect was obtained by the combination of the horse placenta extract.

[0101]

Example 2 Moisturizing Property of Horse Placenta Extract In order to evaluate the moisturizing property of the horse placenta extract of the present invention, the change over time in the transepidermal water loss with a monitor was measured. (Sample solution) Placenta extract of horses of Production Examples 1 and 2 (adjusted to a solid content of 0.0001%) (Measurement device) TEWAMETER TM210; COURAGE + KHAZAKA Elect
ronic Gmbh (monitor) 22-year-old woman, 24-year-old woman, 29-year-old woman, 30-year-old man, 37-year-old man (Method) Apply each sample aqueous solution (1 mL) three times a day to the left and right forearm flexors of the monitor. After the third application, stabilize for 1 hour in a thermo-hygrostat (24 ° C., 50% RH), and then start measuring transepidermal water loss. The measurement is performed at intervals of 2 seconds for 3 minutes, and the average value of all the numerical values is defined as the TEWL value of the test site.
Each blank was measured under the same conditions before sample application.

Table 1 shows the results of the average water change of the five monitors. It has been found that the horse placenta extract according to the present invention suppresses transepidermal water evaporation and exhibits a moisturizing effect.

[0103]

[Table 1]

[0104]

EXAMPLE Skin roughness improvement effect In order to evaluate the improvement effect of the horse placenta extract obtained in Production Examples 1 and 2 on skin roughness, an application test was performed using a guinea pig for which a skin roughness model was prepared. In addition, the sample was adjusted to the same solid content concentration, and only the solvent was used as a comparison. (Method) To a Hartley-type guinea pig (female, 5 weeks of age, 3 animals per group) with depilated back, sodium lauryl sulfate (0.2 g) adjusted to 3% by weight with white petrolatum was continuously and continuously applied for 3 days. Created rough skin. The rough skin preparation site was divided into four minutes, each sample (1.0 mL) was applied three times / day, and three days later, the degree of rough skin was evaluated according to a criterion (score) determined by observation. (Evaluation criteria) Erythema and desquamation are hardly seen 1 point Mild desquamation without erythema 2 points Moderate desquamation without erythema 3 points Desquamation with weak erythema 4 points Desquamation with moderate erythema 5 6 points with desquamation with marked erythema

The results are as shown in Table 2. The equine placenta extract of the present invention was found to be effective in improving skin roughness.

[0106]

[Table 2]

[0107]

[Example] Tyrosinase activity inhibitory activity (Test method) Tyrosine solution (L-tyrosine 0.3mg / mL) 1.0m
L, 2.0 mL of McClubine buffer (pH 6.5) and 0.2 mL of the sample solution were mixed, and the mixture was allowed to stand in a thermostat at 37 ° C. for about 10 minutes.
After adding 0.1mL, measure the absorbance at 475nm
(A) Then, the reaction solution is left in a thermostat at 37 ° C. for 20 minutes, and the absorbance at 475 nm is measured similarly (A ′).
At the same time, as a blank, the absorbance was measured in the same manner using purified water instead of the sample solution (a) and (a '), and the tyrosinase activity inhibition rate was determined by Formula 1. (Specimen) Placenta extract of horses of Production Examples 1 and 2 (solid content: 1.0%)

<Equation 1> Inhibition rate (%) = {(a′−a) − (A′−A)} / (a′−)
a) × 100

[0109]

[Table 3]

The equine placenta extract of the present invention was confirmed to have a tyrosinase activity inhibitory action.

[0111]

EXAMPLES Preparation of Sample Cream and Sample Hair Tonic In order to confirm the safety and effect of the cosmetic composition of the present invention, sample creams in Tables 4 to 5 and sample hair tonics in Tables 6 to 7 were manufactured.

[0112]

[Table 4]

[0113]

[Table 5]

[0114]

[Table 6]

[0115]

[Table 7]

[0116]

Examples 1) Primary skin irritation test Sample creams 1-5 and sample hair tonic 1-5
Was affixed to the skin of a rabbit (about 3,800 g in weight) whose hair was removed from the back. Judgment was performed 24, 48, and 72 hours after application by primary irritation scoring using erythema and edema as indices. As a result, in each animal, all animals did not show any erythema and edema, and were judged as negative.

2) Skin Cumulative Irritation Test Sample creams 1-5 and sample hair tonics 1-5
Was applied to the skin of a Hartley-type guinea pig (female, about 320 g in weight) with hair removed from the flank (length 2 cm, width 4 cm) once a day, 5 times a week, 0.5 mL / animal. Application was performed over 4 weeks and hair removal was performed on the last application day of each week. Judgment was made on the day following the last day of each week, using erythema and edema as indices by a primary irritation scoring method. As a result, all the animals were judged to be negative without any erythema and edema in all animals from 1 to 4 weeks after application.

[0118]

EXAMPLE Whitening Effect In order to evaluate the whitening effect of the cosmetic composition of the present invention, 20 healthy male and female adults were set as subjects, and a circular hole 10 (5 holes) having a diameter of 1.2 cm was formed in the inner part of the left forearm. -2
Row), after pasting the pass, the filibus at 10cm distance
The TL20W / 12UV lamp and the TL20W / 09UV lamp were irradiated simultaneously with 1.5MED once a day for 2 days. Sample creams 1 to 5 and comparisons 1 to 5 were applied to each circular irradiation part of the subject, respectively.
After applying (Tables 4 and 5) an appropriate amount twice a day satisfying sunburn marks for 6 weeks, the whitening effect was judged by the naked eye. Table 8 shows the results.

[0119]

[Table 8]

As is evident from Table 8, a more pronounced whitening effect appears when the horse placenta extract and the whitening component are formulated.

[0121]

[Example] Hair-growth effect Approximately 8 cm ² (length 2 cm, width 4 cm) of the back of a C3H mouse was depilated with an electric clipper and an electric shaver. Next, about 0.2 mL of the sample hair tonic was applied to the depilated back once a day, about 0.2 mL, 5 days a week for 20 days (the test animals were 8 animals in one group, and the back was divided into the left side and the right side. Apply sample). On the 12th and 20th days after application, the image analysis device was used to measure the area ratio (%) at which hair regeneration was observed with respect to the depilated area.
Compared to the control group. FIG. 4 shows the results. "Ogawa et al.'S test method (Fragrance Journal, Vol. 17, No. 5, P. 20-
29 (1989)) "

The experimental animals used were 8-week-old male C3H mice. These animals were housed in a room temperature of 20 to 24 ° C., humidity of 35 to 65%, all-fresh ventilation 15 times / hour, and lighting for 9 hours / day. Animals had free access to solid feed MF (Oriental Yeast Industry) and tap water.

As shown in FIG. 4, by applying a sample hair tonic formulated with a horse placenta extract and a hair growth component,
A more pronounced hair-growth effect appeared.

[0124]

EXAMPLES Preparation of various preparations Various cosmetic compositions according to the present invention were prepared. The formulation examples are shown below, but the invention is not limited thereto.

1) Production Example of Lotion A whitening lotion was produced according to the following formulation. % By weight Sorbitol 2 2.1,3-butylene glycol 2 3. Polyethylene glycol 1000 1 4. Polyoxyethylene oleyl ether (25E.O.) 25 Ethanol 10 6. 6. Placenta extract of horse of Example 1 (solid content concentration: 1.4%) 1.0 Saxifraga extract component (solid content concentration 1.5%) 2.0 8. Sodium lactate 0.2 9. pH adjuster qs. Preservative appropriate amount 11. Purified water 100 residue

2) Production Example of Emulsion Emulsion was produced according to the following formulation. % By weight Squalane 3 2. Vaseline 1 3. Stearyl alcohol 0.3 4. Sorbitan monostearate 1.55. Polyoxyethylene (20) sorbitan monooleate 3 6.1,3-butylene glycol 5 7. Example 2 Horse placenta extract (solids concentration 1.2%) 0.58. N-acetyltyrosine 0.19. Quercetin 0.005 10. Glycolic acid 0.1 11. 11. Ascorbic acid glucoside 0.1 Preservative appropriate amount 13. Purified water 100 residue

3) Production Example of Cream A cream was produced according to the following formulation. % By weight Squalane 20 2. Beeswax 5 3. Refined jojoba oil 5 4. Glycerin monostearate 2 5. Sorbitan monostearate 2 6 Polyoxyethylene (20) sorbitan monostearate 2 7. Glycerin 5 8. 8. Placenta extract of horse of Example 1 (solids concentration: 1.4%) 1.0 9. Placenta extract of horse of Example 2 (solids concentration: 1.7%) 1.0 N-acetyltyrosine sodium 1 11. 11. Tannin extraction component (solid content concentration 1.8%) 0.5 Glutathione 0.01 13. Sodium citrate 0.2 14. Preservative appropriate amount 15. Purified water 100 residue

4) Shampoo Production Example A shampoo was produced according to the following formulation. % By weight Triethanolamine lauryl sulfate 5 2. 3. Polyoxyethylene lauryl ether sulfate Na 12 3.1,3-butylene glycol 4 Lauric acid diethanolamide 2 5. Disodium edetate 0.16. 6. Placenta extract of horse of Example 1 (solids concentration: 1.4%) 1.0 Hop extract component (solid content 2.1%) 1.0 8. Clara extract (solids concentration 0.9%) 0.5 9. 9. Korean ginseng extract component (solid content concentration 0.9%) 1.0 Sodium tartrate 0.2 11. Preservative appropriate amount 12. Purified water 100 residue

5) Production Example of Body Soap A body soap was produced according to the following formulation. % By weight Potassium laurate 15 2. Potassium myristate 5 3. Propylene glycol 5 4. 4. Horse placenta extract of Example 1 2.0 Fujibaka extract (solid content 1.2%) 1.0 6. Sodium citrate 0.17. Sodium lactate 0.18. pH adjuster qs 9. Preservative appropriate amount 10. Purified water 100 residue

6) Production Example of Bath Agent A bath agent was produced according to the following formulation. % By weight Sodium bicarbonate 50 2. 2. anhydrous sodium sulfate 30 Borax 2 4. 4. Horse placenta extract (dry product) of Example 1 N-acetyltyrosine ethyl ester 10 6. Sodium lactate 2 7 Sodium glycolate 1

[0131]

EFFECT OF THE INVENTION The cosmetic composition according to the present invention improves the condition of the skin by the functions such as the physiological healthy effect and skin conditioning effect of the horse placenta extract, which is an essential component, and the other essential component. The whitening component and the hair-growth component are enhanced in permeability and exert an excellent effect that they act more effectively on the skin. Cosmetics that have better functions and effects than conventional products by using anti-inflammatory, anti-allergic, anti-acne, anti-skin roughening, and anti-wrinkle ingredients in addition to whitening and hair growth ingredients It is also possible to obtain a composition.

[Brief description of the drawings]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 shows a change in electrical conductivity of a horse placenta extract application site according to an example (moisture retention of horse placenta extract 1).

FIG. 2 shows the change in electrical conductivity of the equine placenta extract application site according to the example (moisture retention of horse placenta extract 1).

FIG. 3 shows the change in electrical conductivity of the equine placenta extract application site according to the example (moisture retention of horse placenta extract 1).

FIG. 4 shows the effect of the cosmetic composition of the present invention on hair regeneration of C3H mice, performed according to the example (hair growth effect).

────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] December 21, 2000 (200.12.
21)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claim 3

[Correction method] Change

[Correction contents]

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0019

[Correction method] Change

[Correction contents]

Examples of the hair-growing components include carpronium chloride, cepharanthin, nicotinamide, benzyl nicotinate, vitamin E acetate, pantoenyl alcohol, biotin, glyceride pentadecanoate, an extract component of Hypericum perforatum, l-menthol, minoxidil, and canthari tincture. Can be used, such as tincture, pepper tincture, Clara extract component, assembly extract component, Korean ginseng extract component, ginseng extract component, buttonpig extract component, lime extract extract component, calendula extract component, arnica extract component, hop extract component, etc. .

[Procedure amendment 3]

[Document name to be amended] Statement

[Correction target item name]

[Correction method] Change

[Correction contents]

[0114]

[Table 6]

[Procedure amendment 4]

[Document name to be amended] Statement

[Correction target item name]

[Correction method] Change

[Correction contents]

[0115]

[Table 7]

[Procedure amendment]

[Submission date] February 22, 2001 (2001.2.2)
2)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0024

[Correction method] Change

[Correction contents]

In addition, the cosmetic composition of the present invention may optionally contain, in addition to the above-mentioned essential components, any of the following components and additives within a range that does not impair the effects of the present invention. The content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50%.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/48 A61K 7/48 7/50 7/50 35/50 35/50 45/00 45/00 A61P 17/14 A61P 17/14 17/16 17/16 F term (reference) 4C083 AA071 AA072 AA082 AA111 AA112 AA122 AB272 AB312 AB352 AC012 AC022 AC072 AC102 AC122 AC132 AC182 AC242 AC302 AC422 AC442 AC472 AC622 AC662 AC692 AC782 AC852 AD043 AD392 AD392 CC05 CC25 CC38 EE16 EE22 FF01 4C084 AA19 MA02 MA63 ZA891 ZA921 4C087 AA01 BB58 MA02 MA63 ZA89 ZA92

Claims (3)

[Claims] 1. A cosmetic composition essentially comprising an equine placenta extract and a whitening component or a hair growth component. 2. A whitening component comprising kojic acid, arbutin, ascorbic acid or a salt thereof, ascorbic acid phosphate or a magnesium salt thereof, ascorbic acid glucoside,
At least one selected from ellagic acid, rucinol, Yarrow extract, Achillea millefolium extract, Fujikawakama extract, Mulberry extract, Ogon extract, water-soluble silk protein hydrolyzate, Aloe extract, tannic acid, fermented metabolite of lactic acid bacteria The cosmetic composition according to claim 1, which is: (3) a hair-growing component comprising capronium chloride, cepharanthin, nicotinamide, benzyl nicotinate, vitamin E acetate, pantothenyl alcohol, biotin, glyceride pentadecanoate, an extract component of Hypericum perforatum, l-menthol, minoxidil, canthari tincture, 2. The cosmetic composition according to claim 1, wherein the cosmetic composition is at least one selected from pepper tincture, Clara extract component, assembly extract component, Korean ginseng extract component, Chicset ginseng extract component, and buttonpig extract component.