JP2001131016A - Composition for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for external use, e.g. a cosmetic, a medicine for external use for skin, a quasi-drug or the like, which gives an excellent feeling on use without the greasy or residual touch and possesses excellent stability. SOLUTION: This composition for external use is obtained by including (1) a polysaccharide compound which contains [→3)-β-D-glucose (1→4)-β- D-glucuronic acid (1→4)-β-D-glucose(1→4)-α-L-rhamnose (1→] represented by general formula I [wherein, (n) stands for an integer] as a repeated unit and acetyl and glyceryl groups as substituents, preferably in addition, (2) a volatile oil content, e.g. a volatile silicone or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external composition which can be used as a cosmetic, a dermatological drug or a quasi-drug, and the like.

[0002]

2. Description of the Related Art Thickeners are indispensable elements in external compositions from the viewpoints of stability and adjustment of feeling during use.

Conventionally, as a thickening agent, polysaccharides derived from various microorganisms and plants such as a synthetic polymer such as carboxyvinyl polymer, xanthan gum, and gum arabic have been used. However, the carboxyvinyl polymer alone has a very high thickening power, but has the disadvantage that the viscosity is significantly reduced by the addition of salts, whereas xanthan gum, which is not easily affected by salts, has a low viscosity, When this is blended in a large amount in order to improve the thickening power, a sticky feeling in use and a tendency to cause a residual feeling are observed. For this reason, there has been a demand for a new thickening agent that balances the thickening power and the salt resistance and does not have a sticky feeling upon use.

[0004] Further, in an external composition in which various components are blended in a large amount, these components tend to have a sticky feeling in use, and a component capable of solving the problem is provided. Is desired.

Until now, various studies have been made to improve the feeling of use of cosmetics, dermatological drugs and quasi-drugs, and for example, Japanese Patent Application Laid-Open No. 62-114905, "Cosmetics" and Japanese Patent Application Laid-Open No. There is also an invention in which a food gelling agent is blended into an external composition, such as 9-255557 “gel emulsion composition”.

[0006] These inventions are represented by the general formula (II):
It contains a polysaccharide compound that can be produced by Pseudomonas elodea. However, the polysaccharide compounds used in these inventions do not always have sufficient stabilizing ability, which is one of the most important factors as a thickener incorporated in an external composition.

[0007]

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[0008]

SUMMARY OF THE INVENTION Therefore, the problem to be solved by the present invention is that it does not have a sticky feeling of use or a feeling of being left behind,
Cosmetics with excellent usability and stability
An object of the present invention is to provide a composition for external use such as a skin external medicine and a quasi-drug.

[0009]

Means for Solving the Problems We have made intensive studies to solve this problem. As a result, the above Pseu
The inconvenience associated with the polysaccharide compound that can be produced by domonas elodea has been found to be due to the fact that this polysaccharide compound is different from the natural one and is deacylated during purification, and the polysaccharide that Pseudomonas elodea can produce Even if it is a compound, it has been found that the problem can be solved by selecting a polysaccharide compound that has not been deacylated, and preferably combining the compound with a volatile oil component such as volatile silicone. Thus, the present invention has been completed.

That is, the inventor of the present application
(1) [→ 3] -β-D-glucose (1 → 4) -β-D-glucuronic acid (1 → 4)-represented by the general formula (I)
Polysaccharide compounds having β-D-glucose (1 → 4) -α-L-rhamnose (1 →) as a repeating unit and having an acetyl group and a glyceryl group as substituents, preferably further (2) volatile silicones and the like Provided is an external composition containing a volatile oil component (hereinafter, also referred to as the external composition of the present invention).

[0011]

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In the present invention, the term "external composition" means a composition which can be widely applied to the outer skin, and can be used for specific products such as cosmetics, pharmaceuticals, quasi-drugs and the like. It does not question the distinction according to the Pharmaceutical Affairs Law.

[0013]

Embodiments of the present invention will be described below. The composition for external use of the present invention is characterized by containing the polysaccharide compound (I).

The polysaccharide compound (I) is a polysaccharide compound represented by the above formula (I) having glucose, glucuronic acid and rhamnose as constituent sugars and having an acetyl group and a glyceryl group.

The polysaccharide compound (I) has an average of one glyceryl group per repeating unit and one for every other repeating unit.
Acetyl groups are present. Further, the polysaccharide compound (I)
In the above formula, n represents an integer, but in the present invention, preferred n is from 10 to 10,000, and more preferably from 50 to 5,000.

As shown in Table 1, the polysaccharide compound (I) can obtain a higher viscosity at a lower concentration than the deacylated polysaccharide compound of the same kind that can be produced by Pseudomonas elodea. is there.

[0017]

[Table 1]

At present, the polysaccharide compound (I) is
Most preferably, it is obtained as a secreted polysaccharide of eudomonas elodea. However, polysaccharide compound (I) is
Not only naselodea can produce it. That is, P
Microorganisms other than seudomonas elodea, such as genetically modified microorganisms that are more active in producing polysaccharide compound (I), can also be produced. Therefore, as long as the polysaccharide compound (I) has the above structure, the technical scope of the present invention is not limited by the source or the production method of the polysaccharide compound (I).

In order to obtain the polysaccharide compound (I) as a microbial secretion, a microorganism having the ability to produce the polysaccharide compound (I), for example, Pseudomonas elodea is cultured, and the desired polysaccharide compound ( I) may be separated and purified. More specifically, Pseudomonas elodea or the like is inoculated into a general medium, and normal fermentation is performed, and the polysaccharide compound (I) is separated and purified from the resulting fermentation product by a general method such as centrifugation or chromatography. Polysaccharide compound (I) can be produced. In the present invention, it is also possible to use a culture containing the polysaccharide compound (I) or a crude product in the course of purification.

However, in order to obtain a polysaccharide having an acetyl group and a glyceryl group represented by the general formula (I), it is important to avoid an operation or a step that promotes deacylation in the purification step. As the polysaccharide compound (I), those commercially available as products can be used in the present invention. Commercially available polysaccharide compounds (I) include Pseudomonas
Native gellan gum, which is a polysaccharide compound (I) having an acetyl group and a glyceryl group in a culture that can be produced by elodea, is commercially available from Kelco, USA under the trade name Kelcogel LT-100.

[0021] The content of the polysaccharide compound (I) in the composition for external use of the present invention is 0.01-5.
0% by weight, more preferably 0.02% by weight.
More preferably, it is 2.0% by weight.

The topical composition of the present invention preferably contains a volatile oil in addition to the polysaccharide compound (I). As a preferred embodiment of the volatile oil component that can be blended in the external composition of the present invention, a volatile silicone can be mentioned. This volatile silicone is not particularly limited as long as it is a volatile silicone generally used in a composition for external use, and specific examples thereof include cyclic dimethylpolysiloxane of 3 to 6 mer, and the like. Octamethyltetrasiloxane, decamethylcyclopentasiloxane and the like are preferably used. Examples of the volatile oil other than silicone include a branched hydrocarbon having less than 20 carbon atoms and an ester having less than 12 total carbon atoms, and preferably isoparaffin is used.

The content of the volatile oil component in the composition for external use of the present invention can vary depending on the type and the dosage form of the volatile oil component, and is not particularly limited. For example,
When the volatile oil is a silicone oil, it is preferably 0.1 to 40.0% by weight, and more preferably 0.5 to 30.0% by weight, based on the total amount of the composition. More preferred.

In this manner, by blending the polysaccharide compound (I), preferably (2) a volatile oil component with the polysaccharide compound (I), the composition is refreshed and moist without disturbing the dosage form of the composition for external use. It is possible to provide a certain favorable feeling in use and to further improve the stability of the composition. In addition, various components that could not be blended in large amounts due to a strong sticky feeling and a strong residual feeling can be blended without sacrificing the usability of the composition.

The dosage form that the composition for external use of the present invention can adopt is not particularly limited. The present invention can be applied to all external compositions such as, for example, a polysaccharide compound (I), and further contains a base component such as an aqueous phase component and an oil phase component contained in a general external composition, and In addition, surfactants and various components appropriately selected according to various uses and purposes are arbitrarily contained in a range not to impair the effects of the present invention.

The composition for external use of the present invention comprises the polysaccharide compound (I)
Is added to the aqueous phase component, except that, for example, the oil phase component and the aqueous phase component containing the polysaccharide compound (I) are each brought to about 50 to 90 ° C. Heat, mix these, stir emulsify, then
It can be manufactured by a method such as cooling.

The composition for external use of the present invention contains the polysaccharide compound (I)
And a component that can be blended in addition to the volatile silicone, usually, as a component blended in the composition for external use, water; hydrocarbons such as liquid paraffin, squalane, and petrolatum;
Fats and oils such as macadamia nut oil, olive oil, and lanolin (however, the volatile oil described above may be an essential component of the composition for external use of the present invention); waxes such as jojoba oil, carnauba wax, candelilla wax; dimethyl Silicones such as polysiloxane and methylphenylsiloxane, cyclic silicones (the volatile silicone described above may be an essential component of the composition for external use of the present invention); caprylic alcohol, lauryl alcohol, myristyl alcohol, cetyl Higher alcohols such as alcohol, cholesterol and phytosterol; higher fatty acids such as capric acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid and linolenic acid; sorbitan monolaurate, sorbitan monopalmitate, sesquio Sorbitan inmate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene glycol monooleate, polyoxyethylene alkyl ether, polyethylene glycol difatty acid ester, lauroyl diethanolamide, fatty acid dipropanolamide, maltitol hydroxy aliphatic ether Nonionic surfactants such as alkylated polysaccharides, alkyl glucosides, sugar esters, polyether-modified silicones; cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide; sodium palmitate, sodium laurate , Sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine alkyl sulfate, acylmethyl tauri Anionic surfactants such as salts; amphoteric surfactants; silicone surfactants;

Polyethylene glycol, glycerin,
Moisturizing agents such as 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, mucopolysaccharide, hyaluronic acid, chondroitin sulfate, chitin, chitosan; polysaccharides such as gum arabic, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, xanthan gum Thickeners other than compound (I); lower alcohols such as ethanol; antioxidants such as butylhydroxytoluene, tocopherol, and phytin; antibacterial agents such as benzoic acid, salicylic acid, sorbic acid, alkyl parahydroxybenzoate, and hexachlorophene;

Also, amino acids such as glycine, alanine, valine, leucine, threonine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamine, taurine, arginine, histidine and the like, and alkali metal salts and hydrochlorides thereof; acyl sarcosine acid (eg, lauroyl) Sarcosine sodium), glutathione; organic acids such as citric acid, malic acid, tartaric acid, and lactic acid; vitamin A and its derivatives; vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate, vitamin B ₂ and its derivatives , vitamin B _12, vitamin B such as vitamin B ₁₅ and its derivatives; ascorbic acid, ascorbic acid sulfate ester (salt), ascorbic acid phosphate ester (salt), vitamin C such as ascorbic acid dipalmitate; alpha-tocopherol Eroru, beta-tocopherol, .gamma.-tocopherol, vitamin E such as vitamin E acetate; vitamin D; vitamin H, pantothenic acid, vitamins such as pantethine; nicotinamide, benzyl nicotinate, .gamma.-oryzanol, allantoin,
Glycyrrhizic acid (salt), glycyrrhetinic acid and derivatives thereof, hinokitiol, bisabolol, eucalyptol, thymol, inositol, saikosaponin, carrot saponin, saponins such as hetimasaponin, muclodisaponin, pantothenyl ethyl ether, ethinyl estradiol, tranexamic acid , Arbutin, cepharanthin, trimethylglycine, placenta extract and other drugs;

Cedar, Clara, Kouhone, Orange,
Natural extracts extracted with various solvents such as sage, yarrow, mallow, burdock, thyme, touki, spruce, birch, horsetail, loofah, horse chestnut, maronier, yukinoshita, arnica, lily, mugwort, peony, aloe, gardenia, sawara, etc .; neutralization Agents, antioxidants, dyes, fragrances and the like.

Specific examples of the composition for external use of the present invention include cosmetics, skin external medicines and quasi-drugs. More specifically, for example, milky lotion, serum,
Basic cosmetics and quasi-drugs such as creams, makeup cosmetics such as foundations, hair cosmetics such as hair creams, and systemic cosmetics such as body lotions can be mentioned.

[0032]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like. However, the technical scope of the present invention should not be limited to these Examples and the like.

The amounts used in the examples are all percentages by weight based on the amount to be compounded. In the following examples, all native gellan gums used as polysaccharide compound (I) were Kelcogel LT-100 manufactured by Kelco. Gellan gum (deacylated) used as a control was all Kelcogel manufactured by Kelco.

First, prior to disclosure of each formulation example, an evaluation method adopted for the external composition of the present invention will be described. Stability test Regarding the stability over time of the compositions obtained in Example 1 and Comparative Examples 1 to 3, each sample was allowed to stand at 50 ° C. for one month,
The state of the composition was visually checked. In addition, this 50 ℃
The test environment of 1 month is a condition set in consideration of the stability during actual use and storage, and if a clear decrease in quality is observed in this test environment, various use environments are assumed. Unsuitable as cosmetics.

Sensory test for feeling of use The compositions obtained in Examples 1 to 3 and Comparative Examples 1 to 4 were subjected to a sensory evaluation of usability and feeling of use.

That is, five expert panelists used each composition (within one week of storage at room temperature after production) and evaluated the four items of stretchability, lack of stickiness, familiarity, and moistness to “very good (5 (Point) -good (4 points) -normal (3 points) -poor (2 points) -very bad (1 point).
The evaluation results were calculated according to the following criteria by calculating the average value of the evaluations of the five persons.

◎: The average value of the evaluations of five persons was 4.0 to 5.0.
It is. ：: The average value of the evaluations of five persons is 3.0 to 3.9. Δ: The average value of the evaluations of five persons is 2.0 to 2.9. X: The average value of the evaluations of five persons is 1.0 to 1.9.

[Example 1] Ingredients of massage gel ingredients (% by weight) (1) Native gellan gum 0.15 (2) Glycerin 5.0 (3) 1,3-butylene glycol 5.0 (4) Alkyl-modified Carboxyvinyl polymer 0.1 (PEMULEN TR-2) (5) Dimethyl polysiloxane (6cs) 3.0 (6) Silicone surfactant 0.05 (7) Preservative 0.1 (8) Chelating agent 9) Antioxidant appropriate amount (10) pH adjuster appropriate amount (11) Fragrance appropriate amount (12) Purified water residue

Example 2 Content of Massage Gel Component (% by Weight) (1) Native Gellan Gum 0.15 (2) Glycerin 5.0 (3) 1,3-butylene glycol 5.0 (4) Alkyl Modified Carboxyvinyl polymer 0.1 (PEMULEN TR-2) (5) Decamethylcyclopentasiloxane 3.0 (6) Silicone surfactant 0.05 (7) Preservative 0.1 (8) Chelating agent Appropriate amount (9 ) Antioxidant appropriate amount (10) pH adjuster appropriate amount (11) Flavor appropriate amount (12) Purified water residue

[Example 3] Amount of massage gel compounding ingredients (% by weight) (1) Native gellan gum 0.15 (2) Glycerin 5.0 (3) 1,3-butylene glycol 5.0 (4) Alkyl-modified Carboxyvinyl polymer 0.1 (PEMULEN TR-2) (5) Decamethylcyclopentasiloxane 2.0 (6) Dimethylpolysiloxane 6cs 1.0 (7) Silicone surfactant 0.05 (8) Preservative 0. 1 (9) Suitable amount of chelating agent (10) Suitable amount of antioxidant (11) Suitable amount of pH adjuster (12) Suitable amount of fragrance (13) Residual water

[Comparative Example 1] Compounding amount of massage gel compounding component (% by weight) (1) Carboxyvinyl polymer 0.15 (Hibiswako 105) (2) Glycerin 5.0 (3) 1,3-butylene glycol 0 (4) Alkyl-modified carboxyvinyl polymer 0.1 (PEMULEN TR-2) (5) Dimethylpolysiloxane 6cs 3.0 (6) Silicone surfactant 0.05 (7) Preservative 0.1 (8) Chelate (9) Antioxidant (10) pH adjuster (11) Flavor (12) Purified water

[Comparative Example 2] Incorporation amount of massage gel component (% by weight) (1) Carboxyvinyl polymer 0.15 (Hibiswako 105) (2) Glycerin 5.0 (3) 1,3-butylene glycol 0 (4) Alkyl-modified carboxyvinyl polymer 0.1 (PEMULEN TR-2) (5) Decamethylcyclopentasiloxane 3.0 (6) Silicone surfactant 0.05 (7) Preservative 0.1 (8) Chelating agent qs (9) antioxidant qs (10) pH adjuster qs (11) fragrance qs (12) purified water residue

[Comparative Example 3] Ingredient of massage gel blending component (% by weight) (1) Gellan gum 0.15 (2) Glycerin 5.0 (3) 1,3-butylene glycol 5.0 (4) Alkyl-modified carboxy Vinyl polymer 0.1 (PEMULEN TR-2) (5) Decamethylcyclopentasiloxane 3.0 (6) Silicone surfactant 0.05 (7) Preservative 0.1 (8) Chelating agent Suitable amount (9) Antioxidant qs (10) pH adjuster qs (11) perfume qs (12) purified water residue

[Comparative Example 4] Ingredients of massage gel ingredients (% by weight) (1) Gellan gum 0.15 (2) Glycerin 5.0 (3) 1,3-butylene glycol 5.0 (4) Alkyl-modified carboxy Vinyl polymer 0.1 (PEMULEN TR-2) (5) Decamethylcyclopentasiloxane 3.0 (6) Silicone surfactant 0.05 (7) Preservative 0.1 (8) Sodium chloride 0.1 (9) ) Chelating agent qs (10) antioxidant qs (11) pH adjuster qs (12) perfume qs (13) purified water residue Table 2 shows Examples 1-3 and Comparative Examples 1-4 The following shows a comparison.

[0045]

[Table 2]

The stability with time was good in Examples 1 to 3 and Comparative Examples 1 and 2, but in Comparative Example 3 using gellan gum which had been subjected to a deacylation step, it was 1 to 2 days after preparation. It was found that the oil was not suitable for cosmetics, for example, separation occurred during use, and only the separated oil adhered during use.

It is known that the viscosity of gellan gum is increased by the addition of a small amount of salt, and the stability was expected to be improved by the addition of salt (Comparative Example 4). Similarly to the above, there was a problem in stability, and it was found that the composition was not suitable for cosmetics.

Regarding the feeling of use, Examples 1 and 2 containing native gellan gum showed no sticky feeling compared to Comparative Examples 1 and 2 containing a carboxyvinyl polymer as in the prior art. The feeling and familiarity were very good. In Examples 2 and 3 containing a volatile silicone oil, the non-sticky feeling of use and the familiarity, which are the characteristics of the present invention, were much more excellent.

As described above, in Comparative Examples 3 and 4, separation (creaming) was observed within 1 to 2 days after preparation, and it was not suitable as a cosmetic at all. Was not implemented.

Example 4 Whitening Emulsion Compounding Components (Weight%) (1) Native Gellan Gum 0.3 (2) Arbutin 10.0 (3) Dipropylene Glycol 3.0 (4) 1,3-butylene Glycol 5.0 (5) Alkyl-modified carboxyvinyl polymer 0.1 (PEMULEN TR-2) (6) Decamethylcyclopentasiloxane 5.0 (7) Silicone surfactant 0.05 (8) Ethanol 4.0 ( 9) Preservative 0.1 (10) Chelating agent suitable amount (11) Antioxidant proper amount (12) pH adjuster proper amount (13) Coloring agent proper amount (14) Flavor proper amount (15) Purified water residue

Example 5 Whitening Emulsion Compounding Components (% by Weight) (1) Native Gellan Gum 0.15 (2) Carboxyvinyl Polymer 0.15 (Hibiswako 105) (3) Arbutin 10.0 (4) Dipropylene glycol 3.0 (5) 1,3-butylene glycol 5.0 (6) Alkyl-modified carboxyvinyl polymer 0.1 (PEMULEN TR-2) (7) Decamethylcyclopentasiloxane 5.0 (8) Silicone Surfactant 0.05 (9) Ethanol 4.0 (10) Preservative 0.1 (11) Suitable amount of chelating agent (12) Suitable amount of antioxidant (13) Suitable amount of pH adjuster (14) Suitable of coloring agent Amount (15) Appropriate amount of fragrance (16) Purified water balance

Comparative Example 5 Whitening Emulsion Compounding Components (Weight%) (1) Carboxyvinyl Polymer 0.3 (Hibiswako 105) (2) Arbutin 10.0 (3) Dipropylene Glycol 3.0 (4) ) 1,3-butylene glycol 5.0 (5) Alkyl-modified carboxyvinyl polymer 0.1 (PEMULEN TR-2) (6) Decamethylcyclopentasiloxane 5.0 (7) Silicone surfactant 0.05 (8) ) Ethanol 4.0 (9) Preservative 0.1 (10) Chelating agent suitable amount (11) Antioxidant proper amount (12) pH adjuster proper amount (13) Coloring agent proper amount (14) Fragrance proper amount ( 15) Purified water residue Table 3 shows a comparison of the usability of Examples 4 and 5 and Comparative Example 5.

[0053]

[Table 3]

When a large amount of the drug is blended, the sticky use feeling is strong and the familiarity is reduced as in Comparative Example 5, so that the overall evaluation is often significantly reduced. Even in the case where a large amount of a drug is thus mixed, the external use composition of the present invention can suppress the sticky feeling of use as in Example 4, and at the same time, can obtain a good feeling of adaptation. Also, when native gellan gum was blended as a part of the thickener, a remarkable effect was recognized as shown in Example 5.

Hereinafter, various formulations of the composition for external use of the present invention will be described as examples. In addition, the topical compositions of the present invention in these examples had a remarkably less sticky feeling of use and a good feeling of adaptation, as compared with those using the conventional thickener.

Example 6 Cream Blending Components (% by Weight) (1) 1,3-butylene glycol 8.0 (2) Native gellan gum 0.2 (3) Xanthan gum 0.05 (4) Polyoxyethylene (10) Monooleate 1.0 (5) Glycerol monostearate 1.0 (6) Cetyl alcohol 5.0 (7) Beeswax 0.5 (8) Vaseline 2.0 (9) Squalane 10.0 (10) Stearic acid 2.0 (11) Decamethylcyclopentasiloxane 2.0 (12) Potassium hydroxide 0.1 (13) Preservative appropriate amount (14) Colorant appropriate amount (15) Chelating agent appropriate amount ( 16) Appropriate amount of perfume (17) Residual purified water [Preparation method] A humectant, a coloring agent and native gellan gum were added to purified water and heated to 80 ° C to prepare an aqueous phase. A surfactant and a preservative were added to the oil, and the mixture was heated to 70 ° C. This was added to the previous aqueous phase to perform preliminary emulsification. After homogenizing the emulsified particles in the emulsion using a homomixer,
After degassing, filtration and cooling, a desired cream was obtained.

Example 7 Emulsion Compounding Component Amount (% by Weight) (1) 1,3-butylene glycol 5.0 (2) Alkyl-modified carboxyvinyl polymer 0.2 (PEMULEN TR-1) (3) Native Gellan gum 0.1 (4) Liquid paraffin 5.0 (5) Ethanol 1.0 (6) Potassium hydroxide 0.1 (7) Preservative 0.1 (8) Chelating agent suitable amount (9) Antioxidant suitable Amount (10) Perfume Appropriate amount (11) Purified water residue [Production method] A humectant, a chelating agent, and native gellan gum were added to purified water and heated to 80 ° C to prepare an aqueous phase. Separately, liquid paraffin, preservatives, spices, etc.
The mixture was heated at ℃. This was added to the previous aqueous phase to perform preliminary emulsification. Further, an alkyl-modified carboxyvinyl polymer was added to the pre-emulsion and stirred. After homogenizing the emulsified particles in the emulsion using a homomixer, deaeration, filtration and cooling were performed to obtain an emulsion.

Example 8 Cream Ingredients Amount (Weight%) (Aqueous Phase) (1) 1,3-butylene glycol 6.0 (2) Polyethylene glycol 1500 4.0 (3) Native gellan gum 3 (4) Dimethylsiloxane / methyl (polyoxyethylene) siloxane copolymer 1.0 (5) Alkyl-modified carboxyvinyl polymer 0.1 (PEMULEN TR-1) (6) Purified water residue (oil phase) ( 7) Stearyl alcohol 3.0 (8) Hydrogenated lanolin 3.0 (9) Squalane 5.0 (10) Octyldodecanol 8.0 (11) Decamethylcyclopentasiloxane 2.0 (12) Preservative (13) Suitable amount of antioxidant (14) Suitable amount of fragrance [Production method] In purified water, humectant, native gellan gum, alkyl-modified carbox An aqueous phase was prepared by adding the sivinyl polymer and heating to 80 ° C. After the oil was dissolved by heating, a preservative, an antioxidant, and a fragrance were added to adjust the temperature to 80 ° C. This was added to the above aqueous phase, the emulsified particles were homogenized with a homomixer, degassed, filtered, and cooled to obtain a desired cream.

[Example 9] Amount (wt%) of lotion component (1) Dipropylene glycol 10.0 (2) Polyethylene glycol 1500 5.0 (3) Alkyl-modified carboxyvinyl polymer 0.1 (CARBOPOL 1342) (4) Native gellan gum 0.05 (5) Polyoxyethylene (20) Oleyl alcohol ether 0.5 (6) Ethanol 5.0 (7) Potassium hydroxide 0.1 (8) Perfume appropriate amount (9) Color Appropriate amount of agent (10) Appropriate amount of preservative (11) Appropriate amount of chelating agent (12) Appropriate amount of anti-fading agent (13) Residual purified water [Production method] Dissolve a portion of purified water and dissolve the The alkyl-modified carboxyvinyl polymer and native gellan gum were mixed and stirred. Also, to the rest of the purified water, add a humectant, anti-fading agent, etc. and dissolve at room temperature,
The above solution was added thereto to obtain a uniform aqueous solution. Further, a preservative, a surfactant, and a fragrance were added to ethanol to prepare an alcohol solution, which was added to the above aqueous solution and mixed to solubilize. Then, after toning with a coloring agent, the mixture was filtered to obtain a desired lotion.

[Example 10] Packing component blending amount (% by weight) (1) Polyethylene glycol 1500 5.0 (2) Dipropylene glycol 5.0 (3) Sorbitol 5.0 (4) Carboxyvinyl polymer 0 (Hibiswako 103) (5) Native gellan gum 0.3 (6) Polyoxyethylene (9) Lauryl alcohol ether 1.0 (7) Ethanol 5.0 (8) Potassium hydroxide 0.5 (9) Perfume Amount (10) Preservative appropriate amount (11) Purified water residue [Production method] A carboxyvinyl polymer and native gellan gum were added to a part of purified water and dissolved by stirring. Further, a fragrance, a preservative, and a surfactant were added and dissolved in ethanol, and this was added to the above-mentioned aqueous phase to be solubilized. Finally, potassium hydroxide was dissolved in the remaining purified water, this solubilized substance was added to neutralize and deaerated, and then filtered to obtain a desired pack.

Example 11 Sunscreen Agent Compounding Amount (Wt%) (Aqueous Phase) (1) Dipropylene glycol 6.0 (2) Xanthan gum 0.2 (3) Native gellan gum 0.2 (4) ) Potassium hydroxide 0.1 (5) Ascorbic acid 2-glucoside 1.0 (6) Purified water residue (oil phase) (7) Octyl paramethoxycinnamate 6.0 (8) Diparamethoxycinnamate Glyceryl octyl acid 2.0 (9) 4-tert-butyl-4-methoxydibenzoylmethane 2.0 (10) oxybenzone 3.0 (11) decamethylcyclopentasiloxane 5.0 (12) dimethylpolysiloxane (6cs) 1.0 (13) Vaseline 0.5 (14) Cetyl alcohol 1.0 (15) Sorbitan sesquioleate 0.8 ( 6) Polyoxyethylene (20) oleyl alcohol ether 1.2 (17) Suitable amount of antioxidant (18) Suitable amount of preservative (19) Suitable amount of fragrance [Production method] Keep oil phase and water phase at 80 ° C respectively. Heated and dissolved. Then, the oil phase was added to the water phase and emulsified with a homogenizer. This emulsion was cooled by a heat exchanger to obtain a desired sunscreen agent.

Example 12 Whitening Emulsion Compounding Components (% by Weight) (1) Native Gellan Gum 0.01 (2) Carboxyvinyl Polymer 0.15 (3) Arbutin 10.0 (4) Dipropylene Glycol 0 (5) 1,3-butylene glycol 5.0 (6) Alkyl-modified carboxyvinyl polymer 0.1 (PEMULEN TR-2) (7) Octamethylcyclopentasiloxane 0.5 (8) Dimethylpolysiloxane (6cs) 5.0 (9) Silicone surfactant 0.05 (10) Ethanol 4.0 (11) Preservative 0.1 (12) Chelating agent suitable amount (13) Antioxidant proper amount (14) pH adjuster suitable Amount (15) Coloring agent appropriate amount (16) Fragrance appropriate amount (17) Purified water residue

Example 13 Whitening Gel Compounding Components (% by Weight) (1) Native Gellan Gum 1.0 (2) Arbutin 10.0 (3) Dipropylene Glycol 3.0 (4) 1,3-butylene Glycol 5.0 (5) Alkyl-modified carboxyvinyl polymer 0.1 (PEMULEN TR-2) (6) Decamethylcyclopentasiloxane 5.0 (7) Dimethylpolysiloxane (6cs) 5.0 (8) Silicone surfactant Agent 0.05 (9) Ethanol 4.0 (10) Preservative 0.1 (11) Suitable amount of chelating agent (12) Suitable amount of antioxidant (13) Suitable amount of pH adjuster (14) Suitable amount of colorant ( 15) Appropriate amount of fragrance (16) Residual water

[Example 14] Cream blending component blending amount (% by weight) (1) Dimethylpolysiloxane 2.0 (2) Decamethylpentasiloxane 10.0 (3) Octamethylcyclotetrasiloxane 13.0 (4) Trimethylsiloxysilicate 4.0-octamethylcyclotetrasiloxane solution (5) Polyoxyethylene 3.0 • Methylpolysiloxane copolymer (6) Ethanol 3.0 (7) Glycerin 3.0 (8) Dipropylene glycol 5.0 (9) native gellan gum 0.2 (10) polyethylene glycol 6000 0.5 (11) polyvinyl alcohol 0.5 (12) EDTA-3Na · 2H 2 O 2 0.02 (13) dimethyl distearyl 1. 5 Ammonium hectorite (14) Antioxidant appropriate amount (15) Preservative Q.s. (16) Perfume Appropriate amount (17) Purified water Balance

[0065]

According to the present invention, there is provided a composition for external use which is excellent in use sensation without sticky sensation of use or after-remaining sensation and also excellent in stability.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Toshio Yanagi 1050 Nippa-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture Inside Shiseido First Research Center Co., Ltd. (72) Koji Abe 1050 Nippacho, Kohoku-ku, Yokohama-shi, Kanagawa F-term in Shiseido First Research Center Co., Ltd. (reference) 4C076 AA06 AA12 AA16 BB31 EE27 EE30G FF36 4C083 AA082 AB032 AB332 AB442 AC012 AC022 AC072 AC092 AC102 AC122 AC132 AC182 AC212 AC242 AC342 AC392 AC402 AC442 AD112AD212 AD0912 AD352 AD392 AD642 BB14 CC02 CC04 CC05 CC07 CC19 CC23 DD31 DD41 EE01 EE06

Claims (5)

[Claims] [1] [→ 3] -β-D represented by the general formula (I)
-Glucose (1 → 4) -β-D-glucuronic acid (1 →
4) A composition for external use containing a polysaccharide compound having -β-D-glucose (1 → 4) -α-L-rhamnose (1 →) as a repeating unit and having an acetyl group and a glyceryl group as substituents. ] 2. An external composition containing (1) the polysaccharide compound according to claim 1 and (2) a volatile oil component. 3. The volatile oil component is a volatile silicone.
The composition for external use according to claim 2. 4. The polysaccharide compound according to claim 1, wherein the polysaccharide compound is a polysaccharide having glucose, glucuronic acid and rhamnose produced by Pseudomonas elodea as constituent sugars and having an acetyl group and a glyceryl group. Topical composition. 5. The composition for external use according to claim 1, wherein the content of the polysaccharide compound is 0.01 to 5.0% by weight based on the total amount of the composition.