Nothing Special   »   [go: up one dir, main page]

JO3820B1 - أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها - Google Patents

أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها

Info

Publication number
JO3820B1
JO3820B1 JOP/2013/0131A JOP20130131A JO3820B1 JO 3820 B1 JO3820 B1 JO 3820B1 JO P20130131 A JOP20130131 A JO P20130131A JO 3820 B1 JO3820 B1 JO 3820B1
Authority
JO
Jordan
Prior art keywords
antibodies
fel
methods
allergen
basophils
Prior art date
Application number
JOP/2013/0131A
Other languages
English (en)
Inventor
Andrew J Murphy
Jamie Orengo
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Application granted granted Critical
Publication of JO3820B1 publication Critical patent/JO3820B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16311—Influenzavirus C, i.e. influenza C virus
    • C12N2760/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Otolaryngology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<span dir="RTL">يتعلق الاختراع الحالي بتوفير أجسام مضادة ترتبط بمولد حساسية من هرة، </span>Fel d1<span dir="RTL">، وتركيبات تتضمن تلك الاجسام المضادة، وأحماض نووية تشفر الأجسام المضادة وطرق لاستخدام تلك الأجسام المضادة. وفقا لنماذج معينة من الاختراع، تعد الأجسام المضادة عبارة عن أجسام مضادة أحادية النسيلة بشرية كاملة ترتبط بـ </span>Fel d1<span dir="RTL">، تعد الأجسام المضادة وفق الاختراع مفيدة للارتباط بمولد الحساسية </span>Fel d1<span dir="RTL"> في الجسم الحي، بما يمنع الارتباط بمولد الحساسية </span>Fel d1<span dir="RTL"> بـ </span>IgE<span dir="RTL"> متكون سلفا على سطح الخلايا البدينة أو الخلايا القاعدية. بذلك، تعمل الأجسام المضادة على منع إطلاق الهيستامين والعوامل الوسيطة الالتهابية الأخرى من الخلايا البدينة و/أو الخلايا القاعدية، بما يخفف من استجابة غير مستحبة لمسبب الحساسية من هرة في الأفراد المصابين بالحساسية. يمكن كذلك أن تكون الأجسام المضادة وفق الاختراع مفيدة لأغراض تشخيصية لتحديد ما إن كان المريض حساس لمسبب الحساسية من هرة </span>Fel d1<span dir="RTL">.</span>
JOP/2013/0131A 2012-05-03 2013-05-01 أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها JO3820B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261642083P 2012-05-03 2012-05-03
US201261718044P 2012-10-24 2012-10-24
US201361783312P 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
JO3820B1 true JO3820B1 (ar) 2021-01-31

Family

ID=48326501

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2013/0131A JO3820B1 (ar) 2012-05-03 2013-05-01 أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها

Country Status (32)

Country Link
US (6) US9079948B2 (ar)
EP (3) EP2844672B1 (ar)
JP (2) JP6400569B2 (ar)
KR (1) KR102185516B1 (ar)
CN (2) CN104411719B (ar)
AR (1) AR090914A1 (ar)
AU (2) AU2013256251C1 (ar)
BR (2) BR112014026852B1 (ar)
CA (1) CA2871077C (ar)
CY (2) CY1124023T1 (ar)
DK (1) DK2844672T3 (ar)
ES (2) ES2780392T3 (ar)
HK (1) HK1202123A1 (ar)
HR (2) HRP20211932T1 (ar)
HU (2) HUE049440T2 (ar)
IL (1) IL235121B (ar)
IN (1) IN2014DN08767A (ar)
JO (1) JO3820B1 (ar)
LT (2) LT2844672T (ar)
MX (2) MX2014013371A (ar)
MY (3) MY195564A (ar)
NZ (2) NZ733480A (ar)
PL (2) PL2844672T3 (ar)
PT (2) PT2844672T (ar)
RS (2) RS60282B1 (ar)
RU (1) RU2658491C2 (ar)
SG (3) SG10202102919XA (ar)
SI (2) SI3660047T1 (ar)
TW (2) TWI644921B (ar)
UY (1) UY34782A (ar)
WO (1) WO2013166236A1 (ar)
ZA (3) ZA201407302B (ar)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
CN102638971B (zh) 2009-07-08 2015-10-07 科马布有限公司 动物模型及治疗分子
CN103945689B (zh) 2011-09-19 2016-10-19 科马布有限公司 免疫球蛋白基因多样性的操纵及多抗体治疗剂
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
JO3820B1 (ar) * 2012-05-03 2021-01-31 Regeneron Pharma أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها
AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
WO2015027154A2 (en) * 2013-08-23 2015-02-26 Regeneron Pharmaceuticals, Inc. Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (sit)
ES2859373T3 (es) 2013-10-01 2021-10-01 Kymab Ltd Modelos animales y moléculas terapéuticas
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
RS60739B1 (sr) 2014-11-17 2020-09-30 Regeneron Pharma Postupci za lečenje tumora upotrebom cd3xcd20 bispecifičnog antitela
AU2016242866B2 (en) 2015-03-30 2021-06-03 Regeneron Pharmaceuticals, Inc. Heavy chain constant regions with reduced binding to FC gamma receptors
TW202330904A (zh) 2015-08-04 2023-08-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
AU2016319075B2 (en) * 2015-09-08 2022-09-22 Universität Zürich Compositions against cat allergy
EP3445783A2 (en) 2016-04-18 2019-02-27 Celldex Therapeutics, Inc. Agonistic antibodies that bind human cd40 and uses thereof
WO2018039499A1 (en) 2016-08-24 2018-03-01 Regeneron Pharmaceuticals, Inc. Host cell protein modification
US11352417B2 (en) 2016-12-22 2022-06-07 Regeneron Pharmaceuticals, Inc. Method of treating an allergy with allergen-specific monoclonal antibodies
EP3573659A1 (en) 2017-01-24 2019-12-04 Société des Produits Nestlé S.A. Compositions comprising anti-fel d1 antibodies and methods for reducing at least one symptom of human allergy to cats
WO2019010191A1 (en) 2017-07-06 2019-01-10 Regeneron Pharmaceuticals, Inc. CELL CULTURE METHOD FOR PRODUCING GLYCOPROTEIN
AU2018392334A1 (en) 2017-12-22 2020-05-28 Regeneron Pharmaceuticals, Inc. System and method for characterizing drug product impurities
KR20200115485A (ko) 2018-01-31 2020-10-07 리제너론 파마슈티칼스 인코포레이티드 약물 생성물 불순물을 특성화하기 위한 시스템 및 방법
TW202311746A (zh) 2018-02-02 2023-03-16 美商再生元醫藥公司 用於表徵蛋白質二聚合之系統及方法
US20190264293A1 (en) 2018-02-28 2019-08-29 Regeneron Pharmaceuticals, Inc. Systems and methods for identifying viral contaminants
TWI779177B (zh) 2018-03-19 2022-10-01 美商再生元醫藥公司 微晶片毛細管電泳分析及試劑
TW202016125A (zh) 2018-05-10 2020-05-01 美商再生元醫藥公司 用於定量及調節蛋白質黏度之系統與方法
CA3097194A1 (en) * 2018-05-18 2019-11-21 Chan Zuckerberg Biohub, Inc. Methods of isolating allergen-specific antibodies from humans and uses thereof
WO2020046793A1 (en) 2018-08-27 2020-03-05 Regeneron Pharmaceuticals, Inc. Use of raman spectroscopy in downstream purification
MX2021002281A (es) 2018-08-30 2021-05-27 Regeneron Pharma Metodos para caracterizar complejos proteicos.
CA3116732A1 (en) 2019-01-16 2020-07-23 Regeneron Pharmaceuticals, Inc. Methods for identifying free thiols in proteins
MX2021013519A (es) 2019-05-13 2021-12-10 Regeneron Pharma Ensayos de union de ligandos competitivos mejorados.
KR20220066393A (ko) 2019-09-24 2022-05-24 리제너론 파아마슈티컬스, 인크. 크로마토그래피의 사용 및 재생을 위한 시스템 및 방법
MX2022006236A (es) 2019-11-25 2022-06-22 Regeneron Pharma Formulaciones de liberacion sostenida con emulsiones no acuosas.
IL303596A (en) 2020-01-21 2023-08-01 Regeneron Pharma Deglycosylation methods for electrophoresis of glycosylated proteins
US20220064270A1 (en) 2020-08-26 2022-03-03 Regeneron Pharmaceuticals, Inc. Method of treating an allergy with allergen-specific monoclonal antibodies
CA3192999A1 (en) 2020-08-31 2022-03-03 Regeneron Pharmaceuticals, Inc. Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants
WO2022115588A1 (en) 2020-11-25 2022-06-02 Regeneron Pharmaceuticals, Inc. Sustained release formulations using non-aqueous membrane emulsification
JP2024500409A (ja) 2020-12-17 2024-01-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド タンパク質封入マイクロゲルの作製
US12031151B2 (en) 2021-01-20 2024-07-09 Regeneron Pharmaceuticals, Inc. Methods of improving protein titer in cell culture
WO2022187323A1 (en) 2021-03-03 2022-09-09 Regeneron Pharmaceuticals, Inc. Systems and methods for quantifying and modifying protein viscosity
MX2023010794A (es) 2021-03-26 2023-10-25 Regeneron Pharma Metodos y sistemas para el desarrollo de protocolos de mezcla.
MX2023014246A (es) 2021-06-01 2024-01-17 Regeneron Pharma Ensayos y reactivos de microchips de electroforesis capilar.
WO2023039457A1 (en) 2021-09-08 2023-03-16 Regeneron Pharmaceuticals, Inc. A high-throughput and mass-spectrometry-based method for quantitating antibodies and other fc-containing proteins
CA3232463A1 (en) 2021-09-20 2023-03-23 Philip Mellors Methods of controlling antibody heterogeneity
TW202331252A (zh) 2021-10-07 2023-08-01 美商再生元醫藥公司 Ｐｈ計校準與校正
IL311245A (en) 2021-10-07 2024-05-01 Regeneron Pharma Systems and methods for pH modeling and control
CA3236367A1 (en) 2021-10-26 2023-05-04 Michelle Lafond Systems and methods for generating laboratory water and distributing laboratory water at different temperatures
CN114113278B (zh) * 2021-11-24 2024-08-02 中国计量科学研究院 一种基于质谱的体外诊断试剂抗体的表位定位方法
WO2023177836A1 (en) 2022-03-18 2023-09-21 Regeneron Pharmaceuticals, Inc. Methods and systems for analyzing polypeptide variants
WO2023250419A1 (en) 2022-06-23 2023-12-28 Regeneron Pharmaceuticals, Inc. Methods of identifying and evaluating cat allergy gene signatures in a subject by determining a stratified score based on gene expression
US20240198253A1 (en) 2022-12-16 2024-06-20 Regeneron Pharmaceuticals, Inc. Methods and systems for assessing chromatographic column integrity
US20240248097A1 (en) 2023-01-25 2024-07-25 Regeneron Pharmaceuticals, Inc. Mass spectrometry-based characterization of antibodies co-expressed in vivo
WO2024158880A1 (en) 2023-01-25 2024-08-02 Regeneron Pharmaceuticals, Inc. Methods of modeling liquid protein composition stability
WO2024163708A1 (en) 2023-02-01 2024-08-08 Regeneron Pharmaceuticals, Inc. Asymmetrical flow field-flow fractionation with mass spectrometry for biomacromolecule analysis
WO2024178213A2 (en) 2023-02-22 2024-08-29 Regeneron Pharmaceuticals, Inc. System suitability parameters and column aging
WO2024182636A1 (en) 2023-03-01 2024-09-06 Regeneron Pharmaceuticals, Inc. Anti-fel d1 antibody formulations
WO2024200854A1 (en) 2023-03-31 2024-10-03 Alk-Abelló A/S Allergen binding antibodies suitable for treating tree pollen allergies
CN117004650B (zh) * 2023-06-25 2024-05-14 山东立菲生物产业有限公司 一种猫皮屑过敏原组分feld1双链二聚体重组蛋白、制备方法及应用
CN117069865B (zh) * 2023-10-12 2024-03-01 中国农业科学院饲料研究所 一种基于T细胞抗原表位猫过敏原蛋白嵌合肽cFel d 1的原核表达及其卵黄抗体的制备
CN117964767B (zh) * 2024-03-29 2024-08-06 北京恩泽康泰生物科技有限公司 抗rage抗体、细胞外囊泡及其制备方法和应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07503239A (ja) * 1992-01-21 1995-04-06 イミユロジク・フアーマシユーチカル・コーポレーシヨン ヒスタミン誘導体を免疫調節剤として免疫療法で用いる方法
JPH08501799A (ja) * 1992-12-21 1996-02-27 タノックス バイオシステムズ インコーポレイテッド アレルゲン特異的ＩｇＡモノクローナル抗体及びアレルギー治療のための関連物質
GB0002386D0 (en) 2000-02-02 2000-03-22 Novartis Nutrition Ag Therapeutic composition
US6849259B2 (en) 2000-06-16 2005-02-01 Symphogen A/S Polyclonal antibody composition for treating allergy
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20040101920A1 (en) 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
EP1740946B1 (en) 2004-04-20 2013-11-06 Genmab A/S Human monoclonal antibodies against cd20
DK1868642T3 (da) * 2005-03-18 2013-06-24 Cytos Biotechnology Ag Katte-allergenfusionsproteiner og anvendelser deraf
US7566456B2 (en) * 2005-06-23 2009-07-28 Haiming Chen Allergen vaccine proteins for the treatment and prevention of allergic diseases
GB0513878D0 (en) * 2005-07-06 2005-08-10 Mars Inc Cat allergen
WO2007065633A1 (en) * 2005-12-05 2007-06-14 Imvision Ag Modulation of the immune response by administration of intralymphatic transduction allergen (itag) -molecules
WO2007113633A2 (en) * 2006-04-03 2007-10-11 Pfizer Products Inc. Immunogenic compositions comprising cat allergen fel dl
CN101454345B (zh) 2006-06-02 2012-08-08 瑞泽恩制药公司 人il-6受体的高亲和力抗体
AT503690A1 (de) 2006-06-09 2007-12-15 Biomay Ag Hypoallergene moleküle
EP1921142A1 (en) * 2006-11-07 2008-05-14 Cytos Biotechnology AG Selection of human monoclonal antibodies by eukaryotic cell display
RU2448979C2 (ru) * 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
EP2139924B1 (en) * 2007-03-29 2016-07-06 Genmab A/S Bispecific antibodies and methods for production thereof
EP2666787B1 (en) * 2007-05-31 2022-02-09 Genmab A/S STABLE IgG4 ANTIBODIES
GB0710529D0 (en) * 2007-06-01 2007-07-11 Circassia Ltd Vaccine
BRPI0813703A2 (pt) * 2007-07-09 2015-11-03 Nestec Sa métodos para a redução de alergias causadas por alérgenos ambientais
SI2187964T1 (sl) * 2007-08-10 2015-01-30 Regeneron Pharmaceuticals, Inc. Visokoafinitetna humana protitelesa proti humanemu živčnemu rastnemu faktorju
JO3340B1 (ar) * 2010-05-26 2019-03-13 Regeneron Pharma مضادات حيوية لـعامل تمايز النمو 8 البشري
JO3820B1 (ar) * 2012-05-03 2021-01-31 Regeneron Pharma أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها

Also Published As

Publication number Publication date
US10047152B2 (en) 2018-08-14
IL235121A0 (en) 2014-12-31
EP3660047A1 (en) 2020-06-03
US20170210790A1 (en) 2017-07-27
US11174305B2 (en) 2021-11-16
US20160376358A1 (en) 2016-12-29
EP2844672A1 (en) 2015-03-11
CN110240651A (zh) 2019-09-17
PL3660047T3 (pl) 2022-02-14
JP2017153491A (ja) 2017-09-07
CY1124819T1 (el) 2022-11-25
BR112014026852B1 (pt) 2023-01-03
RU2014148502A (ru) 2016-06-27
AU2018203087A1 (en) 2018-05-24
EP3978522A3 (en) 2022-07-06
PL2844672T3 (pl) 2020-08-10
NZ733480A (en) 2019-03-29
US20150299303A1 (en) 2015-10-22
DK2844672T3 (da) 2020-04-20
LT3660047T (lt) 2021-11-10
IN2014DN08767A (ar) 2015-05-22
EP2844672B1 (en) 2020-02-12
CN104411719B (zh) 2019-05-14
AU2013256251C1 (en) 2018-08-23
NZ701124A (en) 2017-07-28
TWI644921B (zh) 2018-12-21
AU2013256251B2 (en) 2018-04-12
US9475869B2 (en) 2016-10-25
MX2020003864A (es) 2020-08-13
TW201803901A (zh) 2018-02-01
IL235121B (en) 2019-06-30
MY181422A (en) 2020-12-21
SI2844672T1 (sl) 2020-07-31
ZA202005273B (en) 2023-11-29
SI3660047T1 (sl) 2021-12-31
RS62636B1 (sr) 2021-12-31
US9079948B2 (en) 2015-07-14
TW201406779A (zh) 2014-02-16
PT3660047T (pt) 2021-11-30
RU2658491C2 (ru) 2018-06-21
CN104411719A (zh) 2015-03-11
SG10201608378UA (en) 2016-11-29
ES2780392T3 (es) 2020-08-25
CN110240651B (zh) 2024-03-08
PT2844672T (pt) 2020-04-30
JP6400569B2 (ja) 2018-10-03
SG10202102919XA (en) 2021-05-28
LT2844672T (lt) 2020-04-10
RS60282B1 (sr) 2020-06-30
CY1124023T1 (el) 2022-03-24
AR090914A1 (es) 2014-12-17
AU2013256251A1 (en) 2014-11-06
JP2015523962A (ja) 2015-08-20
HK1202123A1 (en) 2015-09-18
HUE057062T2 (hu) 2022-04-28
ZA202202846B (en) 2023-11-29
BR112014026852A2 (pt) 2017-07-18
KR20150005666A (ko) 2015-01-14
WO2013166236A1 (en) 2013-11-07
ZA201407302B (en) 2021-08-25
CA2871077C (en) 2021-08-17
US10047153B2 (en) 2018-08-14
JP6603269B2 (ja) 2019-11-06
UY34782A (es) 2013-11-29
KR102185516B1 (ko) 2020-12-02
BR122019023685B1 (pt) 2023-01-17
AU2018203087B9 (en) 2020-03-26
ES2898372T3 (es) 2022-03-07
HUE049440T2 (hu) 2020-09-28
US20220025029A1 (en) 2022-01-27
EP3978522A2 (en) 2022-04-06
MX2014013371A (es) 2015-02-05
MY164101A (en) 2017-11-30
US20180305446A1 (en) 2018-10-25
AU2018203087B2 (en) 2020-03-12
CA2871077A1 (en) 2013-11-07
HRP20211932T1 (hr) 2022-03-18
EP3660047B1 (en) 2021-10-13
SG11201406748QA (en) 2014-11-27
HRP20200652T1 (hr) 2020-07-10
US20130295097A1 (en) 2013-11-07
MY195564A (en) 2023-02-02

Similar Documents

Publication Publication Date Title
ZA202202846B (en) Human antibodies to fel d1 and methods of use thereof
WO2011094259A3 (en) Cd127 binding proteins
MY165273A (en) Anti-cd48 antibodies and uses thereof
PH12014502527B1 (en) St2 antigen binding proteins
MY171180A (en) Anti-hla-b*27 antibodies and uses thereof
UA111340C2 (uk) Антитіло, яке специфічно зв&#39;язується з tnf-альфа людини
MY146664A (en) Antibodies against human il-22 and uses therefor
WO2014012001A3 (en) Use of cart19 to deplete normal b cells to induce tolerance
MY161679A (en) Polypeptides
EA201590247A1 (ru) Антитела к siglec-15
EP4219552A3 (en) Il-11r binding proteins and uses thereof
MX2023000390A (es) Anticuerpos humanos contra bet v 1 y metodos de uso de los mismos.
EP3453723A3 (en) Anti-asic1 antibodies and uses thereof
WO2014165524A3 (en) Methods and compositions for treating and preventing disease associated with avb8 integrin
CY1123519T1 (el) Ανθρωπινα μονοκλωνικα αντισωματα εξουδετερωσης il-ß
BR112013023513A2 (pt) anticorpos que ligam tgf-alfa e epiregulina
MX2013009529A (es) Tratamiento de enfermedad de crohn con fistulas.
IN2014DN09812A (ar)
AR117721A2 (es) Anticuerpos humanos para fel d1 y métodos para usarlos
EA201992651A1 (ru) АНТИТЕЛА ЧЕЛОВЕКА К Bet v 1 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ