IT7868765A0 - Procedimento per la preparazione di acidi 1,2-diidro-3h-pirrolo [1,2-a]-pirrol-1-carbossilici - Google Patents
Procedimento per la preparazione di acidi 1,2-diidro-3h-pirrolo [1,2-a]-pirrol-1-carbossiliciInfo
- Publication number
- IT7868765A0 IT7868765A0 IT7868765A IT6876578A IT7868765A0 IT 7868765 A0 IT7868765 A0 IT 7868765A0 IT 7868765 A IT7868765 A IT 7868765A IT 6876578 A IT6876578 A IT 6876578A IT 7868765 A0 IT7868765 A0 IT 7868765A0
- Authority
- IT
- Italy
- Prior art keywords
- pyrrol
- pyrrole
- dihydro
- procedure
- preparation
- Prior art date
Links
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81837777A | 1977-07-25 | 1977-07-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7868765A0 true IT7868765A0 (it) | 1978-07-24 |
IT1160443B IT1160443B (it) | 1987-03-11 |
Family
ID=25225403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT68765/78A IT1160443B (it) | 1977-07-25 | 1978-07-24 | Procedimento per la preparazione di acidi 1,2-diidro-3h-pirrolo (1,2-a)-pirrol-1-carbossilici |
Country Status (27)
Country | Link |
---|---|
US (1) | US4140698A (it) |
EP (1) | EP0000649B1 (it) |
JP (1) | JPS5424889A (it) |
AT (1) | AT364843B (it) |
AU (1) | AU515352B2 (it) |
CA (1) | CA1111431A (it) |
CS (1) | CS201015B2 (it) |
DD (1) | DD137229A5 (it) |
DE (1) | DE2860560D1 (it) |
DK (1) | DK146720C (it) |
ES (1) | ES472002A1 (it) |
FI (1) | FI64597C (it) |
GR (1) | GR63733B (it) |
HK (1) | HK17186A (it) |
HU (1) | HU178354B (it) |
IE (1) | IE47138B1 (it) |
IL (1) | IL55181A (it) |
IT (1) | IT1160443B (it) |
MY (1) | MY8800142A (it) |
NO (2) | NO166863C (it) |
NZ (1) | NZ187924A (it) |
PL (1) | PL111419B1 (it) |
PT (1) | PT68328A (it) |
SG (1) | SG31884G (it) |
SU (1) | SU1138029A3 (it) |
YU (1) | YU40717B (it) |
ZA (1) | ZA784216B (it) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4232038A (en) * | 1979-08-31 | 1980-11-04 | Syntex (U.S.A.) Inc. | 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids |
EP0034481B1 (en) * | 1980-02-14 | 1984-05-30 | Grigg, Ronald Ernest | 2-methyl-5-thiazole-methylamine and carboxamide derivatives |
US4344943A (en) * | 1980-06-09 | 1982-08-17 | Syntex (U.S.A.) Inc. | 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof |
US4353829A (en) * | 1980-11-21 | 1982-10-12 | Syntex (U.S.A.) Inc. | Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters |
US4397862A (en) * | 1981-10-13 | 1983-08-09 | Syntex (U.S.A.) Inc. | Gastrointestinal sparing thioester drugs |
WO1983001382A1 (en) * | 1981-10-13 | 1983-04-28 | Mroszczak, Edward | Gastrointestinal sparing thioester pro-drugs |
US4457941A (en) * | 1982-03-22 | 1984-07-03 | Syntex (U.S.A.) Inc. | Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes |
US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
EP0117675B1 (en) * | 1983-02-19 | 1986-07-23 | Beecham Group Plc | Benzofuran and benzothiophene-carboxylic-acid derivatives |
US4874871A (en) * | 1987-03-25 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
JP2649168B2 (ja) * | 1988-02-25 | 1997-09-03 | 久光製薬株式会社 | 新規な5,6−ジフェニル−1,2−ジヒドロ−3H−ピロロ[1,2−a]ピロール−1−カルボン酸誘導体 |
WO1995001767A1 (en) * | 1993-07-08 | 1995-01-19 | Cygnus Therapeutic Systems | Monolithic matrix transdermal delivery system |
US5621115A (en) * | 1996-02-21 | 1997-04-15 | Ohmeda Pharmaceutical Products Division Inc. | Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids |
US6191285B1 (en) | 1997-07-03 | 2001-02-20 | Abbott Laboratories | Process for the preparation of ketorolac tromethamine |
ATE323703T1 (de) * | 1998-07-10 | 2006-05-15 | Mallinckrodt Inc | Synthese von verbindungen die zur herstellung von ketorolac dienen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4087539A (en) * | 1976-07-14 | 1978-05-02 | Syntex (U.S.A.) Inc. | 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
JPS539789A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | Production of 55*22floyl** * 55*22thenoyl** * 55*33 floyl** and 55*33thenoyl** 1*22dihydroo3hhpyroro * 1*22a*pyrolee11carboxylic acid derivative |
JPS539788A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative |
US4097579A (en) * | 1977-03-31 | 1978-06-27 | Syntex (U.S.A.) Inc. | 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof |
-
1978
- 1978-05-30 US US05/910,979 patent/US4140698A/en not_active Expired - Lifetime
- 1978-07-20 YU YU1741/78A patent/YU40717B/xx unknown
- 1978-07-20 DE DE7878300174T patent/DE2860560D1/de not_active Expired
- 1978-07-20 EP EP78300174A patent/EP0000649B1/en not_active Expired
- 1978-07-20 PT PT68328A patent/PT68328A/pt unknown
- 1978-07-20 IL IL55181A patent/IL55181A/xx active IP Right Grant
- 1978-07-20 DK DK325078A patent/DK146720C/da not_active IP Right Cessation
- 1978-07-20 CS CS784851A patent/CS201015B2/cs unknown
- 1978-07-20 AT AT0528978A patent/AT364843B/de not_active IP Right Cessation
- 1978-07-20 CA CA307,762A patent/CA1111431A/en not_active Expired
- 1978-07-21 IE IE1473/78A patent/IE47138B1/en not_active IP Right Cessation
- 1978-07-21 DD DD78206857A patent/DD137229A5/xx not_active IP Right Cessation
- 1978-07-21 NZ NZ187924A patent/NZ187924A/xx unknown
- 1978-07-21 PL PL1978208576A patent/PL111419B1/pl unknown
- 1978-07-21 JP JP8852578A patent/JPS5424889A/ja active Granted
- 1978-07-21 FI FI782307A patent/FI64597C/fi not_active IP Right Cessation
- 1978-07-21 HU HU78SI1640A patent/HU178354B/hu unknown
- 1978-07-24 GR GR56852A patent/GR63733B/el unknown
- 1978-07-24 AU AU38269/78A patent/AU515352B2/en not_active Expired
- 1978-07-24 ES ES472002A patent/ES472002A1/es not_active Expired
- 1978-07-24 SU SU782641055A patent/SU1138029A3/ru active
- 1978-07-24 IT IT68765/78A patent/IT1160443B/it active
- 1978-07-24 NO NO78782545A patent/NO166863C/no unknown
- 1978-07-25 ZA ZA784216A patent/ZA784216B/xx unknown
-
1984
- 1984-04-19 SG SG318/84A patent/SG31884G/en unknown
-
1985
- 1985-05-14 NO NO85851935A patent/NO155244C/no unknown
-
1986
- 1986-03-13 HK HK171/86A patent/HK17186A/xx not_active IP Right Cessation
-
1988
- 1988-12-30 MY MY78300174.6A patent/MY8800142A/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE7801428L (sv) | Forfarande for framstellning av cefemkarbonsyror | |
IT7827075A0 (it) | Procedimento per la preparazione di acidi 2-idrossi-naftalin-carbossilici. | |
IT7868765A0 (it) | Procedimento per la preparazione di acidi 1,2-diidro-3h-pirrolo [1,2-a]-pirrol-1-carbossilici | |
IT1097447B (it) | Procedimento per la preparazione di acidi alfa-idrossicarbossilici otticamente attivi | |
IT1100096B (it) | Procedimento per la preparazione di acidi alfa,omega-dicarbossilici | |
IT7968724A0 (it) | Procedimento per la preparazione di acidi 2 4 5 triclorofenossilici esenti da diossina | |
IT1076181B (it) | Procedimento per la preparazione di acidi 1-ammino-alcan-1,1-difosfonici | |
IT1128163B (it) | Procedimento per la preparazione di acidi alcanoici | |
IT1098013B (it) | Procedimento per la preparazione di furanoni | |
IT1110819B (it) | Procedimento per la preparazione di acidi benzen-carbossilici | |
IT1097328B (it) | Procedimento per la preparazione di uretani aromatici | |
IT1106888B (it) | Procedimento per la preparazione di idrossifenil-idantoina | |
AR225134A1 (es) | Procedimiento para la preparacion de acidos 3,7-disustituidos-3-cefem-4-carboxilicos | |
IT1094983B (it) | Procedimento per la preparazione di 3,5 di alogeno-aniline | |
IT1106616B (it) | Metodo per la preparazione di 2/2 ditiodianilina | |
IT1143581B (it) | Procedimento per la produzione di acidi alfa-chetocarbossilici | |
IT1101712B (it) | Procedimento perfezionato per la preparazione di guaiacolo acetil-salicilato | |
IT1107695B (it) | Procedimento per la preparazione di 6-ossamordinani 6-sostituiti | |
IT1109205B (it) | Procedimento per la preparazione di 4-clorochinoline | |
IT1207205B (it) | Procedimento per la preparazione di ciclopropan-nitrili | |
IT1101715B (it) | Procedimento per la preparazione di acido 2,5-dichetogluconico | |
IT1096963B (it) | Procedimento per la preparazione di cloro-s-triazina trioni | |
IT7852005A0 (it) | Procedimento per la preparazione di fenilbutenoni | |
IT1132221B (it) | Procedimento per la preparazione di acidi fenossiacetici | |
IT7921164A0 (it) | Procedimento per la preparazione di acidi omega-formil-alcane/o -alchenoici. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950731 |