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IT201600115597A1 - Nuovi inibitori dell’hiv proteasi contenenti anelli eteroaromatici: sintesi ed attività - Google Patents

Nuovi inibitori dell’hiv proteasi contenenti anelli eteroaromatici: sintesi ed attività

Info

Publication number
IT201600115597A1
IT201600115597A1 IT102016000115597A IT201600115597A IT201600115597A1 IT 201600115597 A1 IT201600115597 A1 IT 201600115597A1 IT 102016000115597 A IT102016000115597 A IT 102016000115597A IT 201600115597 A IT201600115597 A IT 201600115597A IT 201600115597 A1 IT201600115597 A1 IT 201600115597A1
Authority
IT
Italy
Prior art keywords
activities
synthesis
new inhibitors
hiv proteases
proteases containing
Prior art date
Application number
IT102016000115597A
Other languages
English (en)
Inventor
Maria Funicello
Francesco Tramutola
Carlo Bonini
Lucia Chiummiento
Paolo Lupattelli
Original Assignee
Univ Degli Studi Della Basilicata
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Della Basilicata filed Critical Univ Degli Studi Della Basilicata
Priority to IT102016000115597A priority Critical patent/IT201600115597A1/it
Publication of IT201600115597A1 publication Critical patent/IT201600115597A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
IT102016000115597A 2016-11-16 2016-11-16 Nuovi inibitori dell’hiv proteasi contenenti anelli eteroaromatici: sintesi ed attività IT201600115597A1 (it)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT102016000115597A IT201600115597A1 (it) 2016-11-16 2016-11-16 Nuovi inibitori dell’hiv proteasi contenenti anelli eteroaromatici: sintesi ed attività

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102016000115597A IT201600115597A1 (it) 2016-11-16 2016-11-16 Nuovi inibitori dell’hiv proteasi contenenti anelli eteroaromatici: sintesi ed attività

Publications (1)

Publication Number Publication Date
IT201600115597A1 true IT201600115597A1 (it) 2018-05-16

Family

ID=58347750

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102016000115597A IT201600115597A1 (it) 2016-11-16 2016-11-16 Nuovi inibitori dell’hiv proteasi contenenti anelli eteroaromatici: sintesi ed attività

Country Status (1)

Country Link
IT (1) IT201600115597A1 (it)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999067417A2 (en) * 1998-06-23 1999-12-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Fitness assay and associated methods
WO2010006050A1 (en) * 2008-07-09 2010-01-14 Purdue Research Foundation Hiv protease inhibitors and methods for using
WO2012092168A1 (en) * 2010-12-27 2012-07-05 Purdue Research Foundation Fused 6,5 bicyclic ring system p2 ligands, and methods for treating hiv
US20130289067A1 (en) * 2010-12-27 2013-10-31 Arun K. Ghosh Compounds and methods for treating hiv

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999067417A2 (en) * 1998-06-23 1999-12-29 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Fitness assay and associated methods
WO2010006050A1 (en) * 2008-07-09 2010-01-14 Purdue Research Foundation Hiv protease inhibitors and methods for using
WO2012092168A1 (en) * 2010-12-27 2012-07-05 Purdue Research Foundation Fused 6,5 bicyclic ring system p2 ligands, and methods for treating hiv
US20130289067A1 (en) * 2010-12-27 2013-10-31 Arun K. Ghosh Compounds and methods for treating hiv

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GHOSH A K ET AL: "STRUCTURE-BASED DESIGN OF NON-PEPTIDE HIV PROTEASE INHIBITORS", IL FARMACO, ELSEVIER FRANCE * EDITIONS SCIENTIFIQUES ET MEDICALES, FR, vol. 50, no. 1/02, 1 March 2001 (2001-03-01), pages 29 - 32, XP002298273, ISSN: 0014-827X, DOI: 10.1016/S0014-827X(01)01025-4 *
GHOSH ET AL.: "Design and Synthesis of Potent HIV-1 Protease Inhibitors Incorporating Hexahydrofuropyranol-Derived High Affinity P2 Ligands: Structure - Activity Studies and Biological Evaluation", J. MED. CHEM., vol. 54, 31 December 2010 (2010-12-31), pages 622 - 634, XP002769026 *
GHOSH ET AL.: "Enhancing Protein Backbone Binding - A Fruitful Concept for Combating Drug-Resistant HIV", ANGEW. CHEM. INT. ED., vol. 51, no. 8, 20 February 2012 (2012-02-20), pages 1778 - 1802, XP002769027 *

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