IT1317926B1 - Derivati triciclici dell'indolo ad attivita' antiangiogenica. - Google Patents
Derivati triciclici dell'indolo ad attivita' antiangiogenica.Info
- Publication number
- IT1317926B1 IT1317926B1 IT2000RM000570A ITRM20000570A IT1317926B1 IT 1317926 B1 IT1317926 B1 IT 1317926B1 IT 2000RM000570 A IT2000RM000570 A IT 2000RM000570A IT RM20000570 A ITRM20000570 A IT RM20000570A IT 1317926 B1 IT1317926 B1 IT 1317926B1
- Authority
- IT
- Italy
- Prior art keywords
- indole
- antiangiogenic activity
- tricyclic derivatives
- tricyclic
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000RM000570A IT1317926B1 (it) | 2000-11-03 | 2000-11-03 | Derivati triciclici dell'indolo ad attivita' antiangiogenica. |
DK01983768T DK1343789T3 (da) | 2000-11-03 | 2001-10-16 | Tricykliske derivater af indol med antiangiogen aktivitet |
US10/415,896 US6887892B2 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
SK534-2003A SK5342003A3 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
PCT/IT2001/000526 WO2002036597A1 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
EP01983768A EP1343789B1 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
JP2002539355A JP2004513130A (ja) | 2000-11-03 | 2001-10-16 | 抗血管新生活性を有するインドールの三環系誘導体 |
PL01364908A PL364908A1 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
MXPA03003798A MXPA03003798A (es) | 2000-11-03 | 2001-10-16 | Derivados triciclicos de indol con actividad antiangiogenica. |
HU0400546A HUP0400546A3 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity and pharmaceutical compositions containing them |
CZ20031042A CZ297299B6 (cs) | 2000-11-03 | 2001-10-16 | Tricyklické deriváty indolu s antiangiogenními úcinky |
BR0115119-3A BR0115119A (pt) | 2000-11-03 | 2001-10-16 | Derivados tricìclicos de indol com atividade antiangiogênica |
AU1518602A AU1518602A (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
DE60112966T DE60112966T2 (de) | 2000-11-03 | 2001-10-16 | Trizyklische indolderivate mit antiangiogenischer wirkung |
KR10-2003-7005651A KR20030042030A (ko) | 2000-11-03 | 2001-10-16 | 혈관형성 억제 활성을 갖는 인돌의 트리사이클릭 유도체 |
CNB018181996A CN1247589C (zh) | 2000-11-03 | 2001-10-16 | 具有抗血管生成活性的吲哚的三环衍生物 |
AT01983768T ATE302780T1 (de) | 2000-11-03 | 2001-10-16 | Trizyklische indolderivate mit antiangiogenischer wirkung |
ES01983768T ES2247182T3 (es) | 2000-11-03 | 2001-10-16 | Derivados triciclicos de indol con actividad antigiogenica. |
CA002427568A CA2427568A1 (en) | 2000-11-03 | 2001-10-16 | Tricyclic derivatives of indole with antiangiogenic activity |
HK04104343A HK1061244A1 (en) | 2000-11-03 | 2004-06-16 | Tricyclic derivatives of indole with antiangiogenic activity |
US11/032,068 US20050124647A1 (en) | 2000-11-03 | 2005-01-11 | Tricyclic derivatives of indole with antiangiogenic activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000RM000570A IT1317926B1 (it) | 2000-11-03 | 2000-11-03 | Derivati triciclici dell'indolo ad attivita' antiangiogenica. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM20000570A0 ITRM20000570A0 (it) | 2000-11-03 |
ITRM20000570A1 ITRM20000570A1 (it) | 2002-05-03 |
IT1317926B1 true IT1317926B1 (it) | 2003-07-15 |
Family
ID=11454976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT2000RM000570A IT1317926B1 (it) | 2000-11-03 | 2000-11-03 | Derivati triciclici dell'indolo ad attivita' antiangiogenica. |
Country Status (20)
Country | Link |
---|---|
US (2) | US6887892B2 (it) |
EP (1) | EP1343789B1 (it) |
JP (1) | JP2004513130A (it) |
KR (1) | KR20030042030A (it) |
CN (1) | CN1247589C (it) |
AT (1) | ATE302780T1 (it) |
AU (1) | AU1518602A (it) |
BR (1) | BR0115119A (it) |
CA (1) | CA2427568A1 (it) |
CZ (1) | CZ297299B6 (it) |
DE (1) | DE60112966T2 (it) |
DK (1) | DK1343789T3 (it) |
ES (1) | ES2247182T3 (it) |
HK (1) | HK1061244A1 (it) |
HU (1) | HUP0400546A3 (it) |
IT (1) | IT1317926B1 (it) |
MX (1) | MXPA03003798A (it) |
PL (1) | PL364908A1 (it) |
SK (1) | SK5342003A3 (it) |
WO (1) | WO2002036597A1 (it) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6849656B1 (en) | 1999-09-17 | 2005-02-01 | Baylor University | Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents |
US7528165B2 (en) | 2001-12-13 | 2009-05-05 | National Health Research Institutes | Indole compounds |
US7632955B2 (en) | 2001-12-13 | 2009-12-15 | National Health Research Institutes | Indole compounds |
US6800655B2 (en) | 2002-08-20 | 2004-10-05 | Sri International | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents |
US7456289B2 (en) | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
US7297704B2 (en) * | 2005-02-17 | 2007-11-20 | Wyeth | Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives |
ATE481396T1 (de) * | 2006-04-25 | 2010-10-15 | Merck Patent Gmbh | Hexahydro-dibenzofuranderivate |
FR2928645A1 (fr) | 2008-03-14 | 2009-09-18 | Sanofi Aventis Sa | Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
WO2014041125A1 (en) * | 2012-09-13 | 2014-03-20 | Baden-Württemberg Stiftung Gmbh | Specific inhibitors of protein p21 as therapeutic agents |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5100891A (en) * | 1991-01-18 | 1992-03-31 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds |
US5350762A (en) * | 1993-03-08 | 1994-09-27 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydrocyclopent[B]indole methanamines and related compounds |
-
2000
- 2000-11-03 IT IT2000RM000570A patent/IT1317926B1/it active
-
2001
- 2001-10-16 DE DE60112966T patent/DE60112966T2/de not_active Expired - Fee Related
- 2001-10-16 SK SK534-2003A patent/SK5342003A3/sk not_active Application Discontinuation
- 2001-10-16 PL PL01364908A patent/PL364908A1/xx unknown
- 2001-10-16 EP EP01983768A patent/EP1343789B1/en not_active Expired - Lifetime
- 2001-10-16 CN CNB018181996A patent/CN1247589C/zh not_active Expired - Fee Related
- 2001-10-16 KR KR10-2003-7005651A patent/KR20030042030A/ko not_active Application Discontinuation
- 2001-10-16 BR BR0115119-3A patent/BR0115119A/pt not_active IP Right Cessation
- 2001-10-16 CA CA002427568A patent/CA2427568A1/en not_active Abandoned
- 2001-10-16 CZ CZ20031042A patent/CZ297299B6/cs not_active IP Right Cessation
- 2001-10-16 AT AT01983768T patent/ATE302780T1/de not_active IP Right Cessation
- 2001-10-16 WO PCT/IT2001/000526 patent/WO2002036597A1/en active IP Right Grant
- 2001-10-16 ES ES01983768T patent/ES2247182T3/es not_active Expired - Lifetime
- 2001-10-16 US US10/415,896 patent/US6887892B2/en not_active Expired - Fee Related
- 2001-10-16 DK DK01983768T patent/DK1343789T3/da active
- 2001-10-16 AU AU1518602A patent/AU1518602A/xx not_active Withdrawn
- 2001-10-16 HU HU0400546A patent/HUP0400546A3/hu unknown
- 2001-10-16 JP JP2002539355A patent/JP2004513130A/ja active Pending
- 2001-10-16 MX MXPA03003798A patent/MXPA03003798A/es active IP Right Grant
-
2004
- 2004-06-16 HK HK04104343A patent/HK1061244A1/xx not_active IP Right Cessation
-
2005
- 2005-01-11 US US11/032,068 patent/US20050124647A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE302780T1 (de) | 2005-09-15 |
CN1247589C (zh) | 2006-03-29 |
CZ297299B6 (cs) | 2006-11-15 |
EP1343789A1 (en) | 2003-09-17 |
ES2247182T3 (es) | 2006-03-01 |
US20040034052A1 (en) | 2004-02-19 |
CN1471535A (zh) | 2004-01-28 |
ITRM20000570A0 (it) | 2000-11-03 |
BR0115119A (pt) | 2003-09-30 |
DE60112966D1 (de) | 2005-09-29 |
US6887892B2 (en) | 2005-05-03 |
ITRM20000570A1 (it) | 2002-05-03 |
HUP0400546A3 (en) | 2007-08-28 |
CZ20031042A3 (cs) | 2003-10-15 |
SK5342003A3 (en) | 2003-10-07 |
DE60112966T2 (de) | 2006-05-24 |
HUP0400546A2 (hu) | 2004-06-28 |
US20050124647A1 (en) | 2005-06-09 |
DK1343789T3 (da) | 2005-12-27 |
WO2002036597A1 (en) | 2002-05-10 |
KR20030042030A (ko) | 2003-05-27 |
EP1343789B1 (en) | 2005-08-24 |
MXPA03003798A (es) | 2004-04-20 |
HK1061244A1 (en) | 2004-09-10 |
PL364908A1 (en) | 2004-12-27 |
AU1518602A (en) | 2002-05-15 |
JP2004513130A (ja) | 2004-04-30 |
CA2427568A1 (en) | 2002-05-10 |
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