IT1317925B1 - Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante. - Google Patents

Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.

Info

Publication number: IT1317925B1
Authority: IT; Italy
Prior art keywords: heterocycles; tumor; bis; chemosensitizing activity; chemosensitizing
Prior art date: 2000-11-03

Application number

IT2000RM000569A

Other languages

English (en)

Inventor

Mauro Marzi

Patrizia Minetti

Gian Piero Moretti

Giuseppe Giannini

Sergio Penco

Maria Ornella Tinti

Claudio Pisano

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-03

Filing date

2000-11-03

Publication date

2003-07-15

2000-11-03 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2000-11-03 Publication of ITRM20000569A0 publication Critical patent/ITRM20000569A0/it

2000-11-03 Priority to IT2000RM000569A priority Critical patent/IT1317925B1/it

2001-07-26 Priority to HU0400584A priority patent/HUP0400584A2/hu

2001-07-26 Priority to MXPA03003942A priority patent/MXPA03003942A/es

2001-07-26 Priority to BR0115139-8A priority patent/BR0115139A/pt

2001-07-26 Priority to US10/415,898 priority patent/US7084166B2/en

2001-07-26 Priority to PCT/IT2001/000407 priority patent/WO2002036561A1/en

2001-07-26 Priority to EP01963372A priority patent/EP1337511A1/en

2001-07-26 Priority to JP2002539321A priority patent/JP2004513110A/ja

2001-07-26 Priority to CNB2005100790913A priority patent/CN100351234C/zh

2001-07-26 Priority to PL01364907A priority patent/PL364907A1/xx

2001-07-26 Priority to KR10-2003-7006154A priority patent/KR20030045165A/ko

2001-07-26 Priority to CNB018182933A priority patent/CN1232518C/zh

2001-07-26 Priority to CA002427565A priority patent/CA2427565A1/en

2001-07-26 Priority to SK535-2003A priority patent/SK5352003A3/sk

2001-07-26 Priority to AU2001284392A priority patent/AU2001284392B8/en

2001-07-26 Priority to CZ20031178A priority patent/CZ20031178A3/cs

2002-05-03 Publication of ITRM20000569A1 publication Critical patent/ITRM20000569A1/it

2003-07-15 Application granted granted Critical

2003-07-15 Publication of IT1317925B1 publication Critical patent/IT1317925B1/it

2004-06-16 Priority to HK04104340A priority patent/HK1061243A1/xx

2007-06-15 Priority to AU2007202805A priority patent/AU2007202805A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)

IT2000RM000569A 2000-11-03 2000-11-03 Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante. IT1317925B1 (it)

Priority Applications (18)

Application Number	Priority Date	Filing Date	Title
IT2000RM000569A IT1317925B1 (it)	2000-11-03	2000-11-03	Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
CNB2005100790913A CN100351234C (zh)	2000-11-03	2001-07-26	具有抗肿瘤和化学敏感活性的双杂环化合物
KR10-2003-7006154A KR20030045165A (ko)	2000-11-03	2001-07-26	항 종양 및 화학적 감작 활성을 갖는 비스 헤테로사이클릭화합물
BR0115139-8A BR0115139A (pt)	2000-11-03	2001-07-26	Compostos bis-heterocìclicos com atividade antitumor e quimiossensibilizante
US10/415,898 US7084166B2 (en)	2000-11-03	2001-07-26	Bis-heterocyclic compounds with antitumour and chemosensitising activity
PCT/IT2001/000407 WO2002036561A1 (en)	2000-11-03	2001-07-26	Bis-heterocyclic compounds with antitumour and chemosensitising activity
EP01963372A EP1337511A1 (en)	2000-11-03	2001-07-26	Bis-heterocyclic compounds with antitumour and chemosensitising activity
JP2002539321A JP2004513110A (ja)	2000-11-03	2001-07-26	抗腫瘍および化学感作活性を有するビス−複素環式化合物
HU0400584A HUP0400584A2 (hu)	2000-11-03	2001-07-26	Tumorellenes és kemoszenzitizáló hatású bisz-heterociklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények
PL01364907A PL364907A1 (en)	2000-11-03	2001-07-26	Bis-heterocyclic compounds with antitumour and chemosensitising activity
MXPA03003942A MXPA03003942A (es)	2000-11-03	2001-07-26	Compuestos bis-heterociclicos con actividad antitumoral y quimiosensibilizante.
CNB018182933A CN1232518C (zh)	2000-11-03	2001-07-26	具有抗肿瘤和化学敏感活性的双杂环化合物
CA002427565A CA2427565A1 (en)	2000-11-03	2001-07-26	Bis-heterocyclic compounds with antitumour and chemosensitising activity
SK535-2003A SK5352003A3 (en)	2000-11-03	2001-07-26	Bis-heterocyclic compounds with antitumour and chemosensitising activity
AU2001284392A AU2001284392B8 (en)	2000-11-03	2001-07-26	Bis-heterocyclic compounds with antitumour and chemosensitising activity
CZ20031178A CZ20031178A3 (cs)	2000-11-03	2001-07-26	Bis-heterocyklické sloučeniny s protinádorovými chemosensitivizujícími účinky
HK04104340A HK1061243A1 (en)	2000-11-03	2004-06-16	Bis-heterocyclic compounds with antitumour and chemosensitising a activity
AU2007202805A AU2007202805A1 (en)	2000-11-03	2007-06-15	Bis-heterocyclic compounds with antitumour and chemosensitising activity

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2000RM000569A IT1317925B1 (it)	2000-11-03	2000-11-03	Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.

Publications (3)

Publication Number	Publication Date
ITRM20000569A0 ITRM20000569A0 (it)	2000-11-03
ITRM20000569A1 ITRM20000569A1 (it)	2002-05-03
IT1317925B1 true IT1317925B1 (it)	2003-07-15

Family

ID=11454975

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT2000RM000569A IT1317925B1 (it)	2000-11-03	2000-11-03	Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.

Country Status (16)

Country	Link
US (1)	US7084166B2 (it)
EP (1)	EP1337511A1 (it)
JP (1)	JP2004513110A (it)
KR (1)	KR20030045165A (it)
CN (2)	CN1232518C (it)
AU (2)	AU2001284392B8 (it)
BR (1)	BR0115139A (it)
CA (1)	CA2427565A1 (it)
CZ (1)	CZ20031178A3 (it)
HK (1)	HK1061243A1 (it)
HU (1)	HUP0400584A2 (it)
IT (1)	IT1317925B1 (it)
MX (1)	MXPA03003942A (it)
PL (1)	PL364907A1 (it)
SK (1)	SK5352003A3 (it)
WO (1)	WO2002036561A1 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060211759A1 (en) *	2001-07-26	2006-09-21	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Bis-heterocyclic compounds with antitumour and chemosensitising activity
US6933316B2 (en)	2001-12-13	2005-08-23	National Health Research Institutes	Indole compounds
US7632955B2 (en)	2001-12-13	2009-12-15	National Health Research Institutes	Indole compounds
US7528165B2 (en)	2001-12-13	2009-05-05	National Health Research Institutes	Indole compounds
US6800655B2 (en)	2002-08-20	2004-10-05	Sri International	Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
DE60336646D1 (de) *	2003-08-07	2011-05-19	Nat Health Research Institutes	Indol-Verbindungen als Inhibitoren der Tubulin-Polymerisation zur Behandlung von angiogenesisbezogenen Erkrankungen
DE10359462A1 (de) *	2003-12-17	2005-07-28	Westfälische Wilhelms-Universität Münster	Neuartige Platinkomplexverbindungen, Verfahren zu deren Herstellung sowie deren Verwendung für die Herstellung einer pharmazeutischen Zusammensetzung zur Behandlung von Krebserkrankungen
US7456289B2 (en)	2004-12-31	2008-11-25	National Health Research Institutes	Anti-tumor compounds
WO2006125324A1 (en) *	2005-05-27	2006-11-30	Queen's University At Kingston	Treatment of protein folding disorders
TW200716545A (en) *	2005-06-10	2007-05-01	Sigma Tau Ind Farmaceuti	Indole derivatives having anti-tumor activity
US9969686B2 (en)	2014-08-05	2018-05-15	Wisconsin Alumni Research Foundation	Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
AU2019251579B2 (en) *	2018-04-12	2024-08-29	Versicolor Technologies, Llc	Photoprotective compositions containing Malassezia-derived compounds and/or chemical analogs thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3738237A1 (de) *	1987-11-11	1989-05-24	Bayer Ag	Bis-indolyl-ethylen
AU7661594A (en) *	1993-09-22	1995-04-10	Glaxo Wellcome House	Bis(amidinobenzimidazolyl)alkanes as antiviral agents
EP0887348A1 (en) *	1997-06-25	1998-12-30	Boehringer Mannheim Italia S.p.A.	Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them

2000
- 2000-11-03 IT IT2000RM000569A patent/IT1317925B1/it active
2001
- 2001-07-26 MX MXPA03003942A patent/MXPA03003942A/es unknown
- 2001-07-26 JP JP2002539321A patent/JP2004513110A/ja active Pending
- 2001-07-26 AU AU2001284392A patent/AU2001284392B8/en not_active Ceased
- 2001-07-26 EP EP01963372A patent/EP1337511A1/en not_active Withdrawn
- 2001-07-26 PL PL01364907A patent/PL364907A1/xx not_active Application Discontinuation
- 2001-07-26 CA CA002427565A patent/CA2427565A1/en not_active Abandoned
- 2001-07-26 CN CNB018182933A patent/CN1232518C/zh not_active Expired - Fee Related
- 2001-07-26 WO PCT/IT2001/000407 patent/WO2002036561A1/en active IP Right Grant
- 2001-07-26 KR KR10-2003-7006154A patent/KR20030045165A/ko not_active Application Discontinuation
- 2001-07-26 US US10/415,898 patent/US7084166B2/en not_active Expired - Fee Related
- 2001-07-26 SK SK535-2003A patent/SK5352003A3/sk not_active Application Discontinuation
- 2001-07-26 CZ CZ20031178A patent/CZ20031178A3/cs unknown
- 2001-07-26 BR BR0115139-8A patent/BR0115139A/pt not_active IP Right Cessation
- 2001-07-26 HU HU0400584A patent/HUP0400584A2/hu unknown
- 2001-07-26 CN CNB2005100790913A patent/CN100351234C/zh not_active Expired - Fee Related
2004
- 2004-06-16 HK HK04104340A patent/HK1061243A1/xx not_active IP Right Cessation
2007
- 2007-06-15 AU AU2007202805A patent/AU2007202805A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US7084166B2 (en)	2006-08-01
WO2002036561A1 (en)	2002-05-10
US20040053987A1 (en)	2004-03-18
CN1473150A (zh)	2004-02-04
PL364907A1 (en)	2004-12-27
CN100351234C (zh)	2007-11-28
JP2004513110A (ja)	2004-04-30
MXPA03003942A (es)	2004-05-24
AU2001284392B2 (en)	2007-03-08
CA2427565A1 (en)	2002-05-10
SK5352003A3 (en)	2003-11-04
CN1733722A (zh)	2006-02-15
AU2007202805A1 (en)	2007-07-12
EP1337511A1 (en)	2003-08-27
AU8439201A (en)	2002-05-15
ITRM20000569A0 (it)	2000-11-03
CN1232518C (zh)	2005-12-21
KR20030045165A (ko)	2003-06-09
AU2001284392B8 (en)	2007-04-05
HUP0400584A2 (hu)	2004-06-28
ITRM20000569A1 (it)	2002-05-03
CZ20031178A3 (cs)	2003-11-12
BR0115139A (pt)	2003-09-30
HK1061243A1 (en)	2004-09-10

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TR199902372A3 (tr)	2000-04-21	Sulfanilsilanlar.
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MA25391A1 (fr)	2002-04-01	Inhibiteurs d'alcenyl et alcynyl metalloproteases.
IT1317925B1 (it)	2003-07-15	Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
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BR0204639B1 (pt)	2010-06-29	colheitadeira dotada de suporte de duto e estrutura de transição.
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IT1307143B1 (it)	2001-10-29	Dispositivo di selezione e impilaggio.
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DE60005282D1 (de)	2003-10-23	Golfschlägerkopf, golfschläger und golfschlägerset
FI19992468A (fi)	2001-05-18	Tuoli
ITMI20000005A0 (it)	2000-01-05	Benzilisotiourre ad attivita' fungicida
ES1042871Y (es)	2000-03-01	Pieza para colchones y similares.
NL1013323A1 (nl)	1999-11-24	Stroomafnemer en koppelstuk daarvoor.
ES1041565Y (es)	1999-12-16	Salva orejas y similares.
ES1042496Y (es)	2000-02-01	"pilona sumible".
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