Nothing Special   »   [go: up one dir, main page]

IT1317358B1 - Derivati cross-linkati dell'acido ialuronico. - Google Patents

Derivati cross-linkati dell'acido ialuronico.

Info

Publication number
IT1317358B1
IT1317358B1 IT2000PD000207A ITPD20000207A IT1317358B1 IT 1317358 B1 IT1317358 B1 IT 1317358B1 IT 2000PD000207 A IT2000PD000207 A IT 2000PD000207A IT PD20000207 A ITPD20000207 A IT PD20000207A IT 1317358 B1 IT1317358 B1 IT 1317358B1
Authority
IT
Italy
Prior art keywords
derivatives
cross
hyaluronic acid
preparation
linkated
Prior art date
Application number
IT2000PD000207A
Other languages
English (en)
Inventor
Davide Renier
Vittorio Crescenzi
Andrea Francescangeli
Original Assignee
Fidia Advanced Biopolymers Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl
Publication of ITPD20000207A0 publication Critical patent/ITPD20000207A0/it
Priority to IT2000PD000207A priority Critical patent/IT1317358B1/it
Priority to JP2002523964A priority patent/JP2004507588A/ja
Priority to CA002423384A priority patent/CA2423384C/en
Priority to AT01982230T priority patent/ATE272654T1/de
Priority to US10/363,273 priority patent/US7125860B1/en
Priority to ES01982230T priority patent/ES2227297T3/es
Priority to AU2002213870A priority patent/AU2002213870B2/en
Priority to EP01982230A priority patent/EP1313772B1/en
Priority to PCT/EP2001/010063 priority patent/WO2002018450A1/en
Priority to AU1387002A priority patent/AU1387002A/xx
Priority to DE60104703T priority patent/DE60104703T2/de
Publication of ITPD20000207A1 publication Critical patent/ITPD20000207A1/it
Application granted granted Critical
Publication of IT1317358B1 publication Critical patent/IT1317358B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Dental Preparations (AREA)
IT2000PD000207A 2000-08-31 2000-08-31 Derivati cross-linkati dell'acido ialuronico. IT1317358B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT2000PD000207A IT1317358B1 (it) 2000-08-31 2000-08-31 Derivati cross-linkati dell'acido ialuronico.
AU2002213870A AU2002213870B2 (en) 2000-08-31 2001-08-31 New cross-linked derivatives of hyaluronic acid
CA002423384A CA2423384C (en) 2000-08-31 2001-08-31 New cross-linked derivatives of hyaluronic acid
AT01982230T ATE272654T1 (de) 2000-08-31 2001-08-31 Neue vernetzte derivate der hyaluronsäure.
US10/363,273 US7125860B1 (en) 2000-08-31 2001-08-31 Cross-linked derivatives of hyaluronic acid
ES01982230T ES2227297T3 (es) 2000-08-31 2001-08-31 Nuevos derivados entrecruzados de acido hialuronico.
JP2002523964A JP2004507588A (ja) 2000-08-31 2001-08-31 ヒアルロン酸の新規架橋誘導体
EP01982230A EP1313772B1 (en) 2000-08-31 2001-08-31 New cross-linked derivatives of hyaluronic acid
PCT/EP2001/010063 WO2002018450A1 (en) 2000-08-31 2001-08-31 New cross-linked derivatives of hyaluronic acid
AU1387002A AU1387002A (en) 2000-08-31 2001-08-31 New cross-linked derivatives of hyaluronic acid
DE60104703T DE60104703T2 (de) 2000-08-31 2001-08-31 Neue vernetzte derivate der hyaluronsäure.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000PD000207A IT1317358B1 (it) 2000-08-31 2000-08-31 Derivati cross-linkati dell'acido ialuronico.

Publications (3)

Publication Number Publication Date
ITPD20000207A0 ITPD20000207A0 (it) 2000-08-31
ITPD20000207A1 ITPD20000207A1 (it) 2002-03-03
IT1317358B1 true IT1317358B1 (it) 2003-06-16

Family

ID=11452055

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000PD000207A IT1317358B1 (it) 2000-08-31 2000-08-31 Derivati cross-linkati dell'acido ialuronico.

Country Status (10)

Country Link
US (1) US7125860B1 (it)
EP (1) EP1313772B1 (it)
JP (1) JP2004507588A (it)
AT (1) ATE272654T1 (it)
AU (2) AU1387002A (it)
CA (1) CA2423384C (it)
DE (1) DE60104703T2 (it)
ES (1) ES2227297T3 (it)
IT (1) IT1317358B1 (it)
WO (1) WO2002018450A1 (it)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1249247B1 (en) * 2001-03-30 2007-02-28 Chisso Corporation Pharmaceutical preparation for the treatment of gynecological diseases
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
ITPD20020003A1 (it) * 2002-01-11 2003-07-11 Fidia Advanced Biopolymers Srl Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori.
AU2002327105B2 (en) * 2002-08-16 2007-07-26 Denki Kagaku Kogyo Kabushiki Kaisha Separate type medical material
ITPD20020271A1 (it) 2002-10-18 2004-04-19 Fidia Farmaceutici Composti chimico-farmaceutici costituiti da derivati dei taxani legati covalentemente all'acido ialuronico o ai suoi derivati.
PL377477A1 (pl) 2002-12-11 2006-02-06 Ferrosan A/S Materiały na bazie żelatyny jako waciki
WO2004060404A1 (ja) * 2002-12-27 2004-07-22 Chugai Seiyaku Kabushiki Kaisha 薬物担体
US6982298B2 (en) 2003-01-10 2006-01-03 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8138265B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
US8137688B2 (en) 2003-01-10 2012-03-20 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
JP4459543B2 (ja) 2003-03-17 2010-04-28 株式会社メドジェル 徐放性ハイドロゲル製剤
AR054637A1 (es) 2004-01-30 2007-07-11 Ferrosan As Aerosoles y composiciones hemostaticas
ITPD20040053A1 (it) * 2004-02-27 2004-05-27 Fidia Advanced Biopolymers Srl Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi
CA2572804C (en) * 2004-07-09 2013-04-02 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
EP1786480B1 (en) 2004-07-09 2016-09-21 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
ITPD20050242A1 (it) 2005-08-03 2007-02-04 Fidia Farmaceutici Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
KR20080080481A (ko) * 2005-09-02 2008-09-04 콜바르 라이프사이언스 리미티드 교차-결합된 다당류 및 단백질 매트릭스 및 그의 제조 방법
CA2624362C (en) * 2005-10-03 2015-05-26 Mark A. Pinsky Liposomes comprising collagen and their use in improved skin care
CN100348621C (zh) * 2005-12-02 2007-11-14 凌沛学 透明质酸铋及其制备方法和应用
EP2049572A1 (en) * 2006-08-04 2009-04-22 Novozymes Biopolymer A/S Branched hyaluronic acid and method of manufacture
ITMI20061726A1 (it) * 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
ITMI20071724A1 (it) 2007-09-05 2009-03-06 Fidia Farmaceutici Formulazioni topiche antivirali in forma di gel bioadesivo
GB0722507D0 (en) * 2007-11-19 2007-12-27 Zhao Xiaobin Hyaluronic acid personal lubricant
RU2366666C1 (ru) * 2007-12-20 2009-09-10 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения сшитых солей гиалуроновой кислоты в водной среде
WO2009102967A2 (en) 2008-02-13 2009-08-20 The Cleveland Clinic Foundation Molecular enhancement of extracellular matrix and methods of use
CA2716872C (en) 2008-02-29 2015-02-10 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
JP5757861B2 (ja) 2008-04-24 2015-08-05 メドトロニック，インコーポレイテッド キトサン−含有保護用組成物
CA2721937C (en) 2008-04-24 2016-07-12 Medtronic, Inc. Protective gel based on chitosan and oxidized polysaccharide
AU2009240509B2 (en) 2008-04-24 2014-08-21 Medtronic, Inc. Rehydratable thiolated polysaccharide particles and sponge
CA2721986C (en) * 2008-04-24 2017-03-14 Medtronic, Inc. Rehydratable polysaccharide particles and sponge
EP2300042A4 (en) 2008-04-30 2012-05-02 Cleveland Clinic Foundation COMPOSITIONS AND METHODS FOR TREATING URINARY INCONTINENCE
AU2009288118B2 (en) 2008-09-02 2014-12-11 Allergan, Inc. Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
KR101092301B1 (ko) 2009-06-04 2011-12-13 포항공과대학교 산학협력단 히알루로난 하이드로겔의 ｘ-선 절삭법
IT1399351B1 (it) 2009-06-16 2013-04-16 Fidia Farmaceutici Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
IT1395392B1 (it) 2009-08-27 2012-09-14 Fidia Farmaceutici Geli viscoelastici come nuovi filler
CZ2009835A3 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
CZ302504B6 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Derivát kyseliny hyaluronové oxidovaný v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd, zpusob jeho prípravy a zpusob jeho modifikace
CN101831005B (zh) * 2010-04-27 2012-08-15 中国药科大学 pH敏感型壳聚糖衍生物及其在药剂学中的应用
ES2385239B1 (es) 2010-09-30 2013-06-19 Proteos Biotech S.L.U. Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno.
CZ304072B6 (cs) * 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
CZ303879B6 (cs) 2012-02-28 2013-06-05 Contipro Biotech S.R.O. Deriváty na bázi kyseliny hyaluronové schopné tvorit hydrogely, zpusob jejich prípravy, hydrogely na bázi techto derivátu, zpusob jejich prípravy a pouzití
EP2822474B1 (en) 2012-03-06 2018-05-02 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
CZ2012282A3 (cs) * 2012-04-25 2013-11-06 Contipro Biotech S.R.O. Zesítovaný derivát hyaluronanu, zpusob jeho prípravy, hydrogel a mikrovlákna na jeho bázi
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
KR101443673B1 (ko) * 2012-08-07 2014-09-26 주식회사 제네웰 히알루론산 유도체 스펀지의 제조방법 및 그에 의하여 제조된 히알루론산 유도체 스펀지
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
CZ2012842A3 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
BR112015030612B1 (pt) 2013-06-21 2020-07-21 Ferrosan Medical Devices A/S método para preparar uma composição seca
WO2015086028A1 (en) 2013-12-11 2015-06-18 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
CZ2014150A3 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
EP3141943B1 (en) 2014-05-09 2022-07-13 Interojo Inc. Hydrogel contact lens having wet surface, and manufacturing method therefor
ES2894829T3 (es) 2014-06-15 2022-02-16 Yeda Res & Dev Tratamiento de superficies mediante polímeros solubles en agua y lípidos/liposomas
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
BR112017007466B1 (pt) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ306479B6 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
US20160367705A1 (en) * 2015-06-16 2016-12-22 New York University Nanoparticles comprised of shells associated with charged entities and formed from monomers and methods of making and using nanoparticles
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
AU2016290433B2 (en) 2015-07-03 2018-05-24 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
KR101784863B1 (ko) 2015-09-03 2017-10-13 (주)진우바이오 히알루론산염이 코팅된 고 기능성 봉합사의 제조방법 및 이로부터 제조된 고 기능성 봉합사
CN108884173A (zh) 2015-12-29 2018-11-23 高德美股份公司 用于裂解酰胺键的方法
EP3252081A1 (en) * 2016-05-31 2017-12-06 Galderma S.A. Hydrolysis of ester bonds in amide crosslinked glycosaminoglycans
EP3252082A1 (en) * 2016-05-31 2017-12-06 Galderma S.A. Method for deacetylation of biopolymers
EP3252080A1 (en) * 2016-05-31 2017-12-06 Galderma S.A. Method for preparing acylated crosslinked glycosaminoglycans
ITUB20169882A1 (it) * 2016-01-08 2017-07-08 Flame S R L Vitamina E per l’uso nel trattamento e nella prevenzione delle infezioni da biofilm.
SG10201913342UA (en) 2016-04-27 2020-03-30 Anika Therapeutics Inc Compositions for use in treating tendon degeneration
PT3623390T (pt) 2016-05-31 2023-10-27 Galderma Sa Reticulador de hidrato de carbono
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
US10590257B2 (en) 2016-09-26 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Biomimetic, moldable, self-assembled cellulose silica-based trimeric hydrogels and their use as viscosity modifying carriers in industrial applications
IL250852B (en) * 2017-02-28 2018-02-28 Prudentix Ltd Periodontal preparation
AR111190A1 (es) 2017-03-22 2019-06-12 Genentech Inc Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados
US11969526B2 (en) 2017-04-03 2024-04-30 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
US11975123B2 (en) 2018-04-02 2024-05-07 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
CN109956727B (zh) * 2017-12-14 2020-04-10 北新集团建材股份有限公司 一种除甲醛的纸面石膏板及其制备方法
EP4368217A3 (en) 2018-01-10 2024-07-31 The Provost, Fellows, Scholars and other Members of Board of Trinity College Dublin System and methods for sealing a channel in tissue
WO2020144372A1 (en) 2019-01-10 2020-07-16 The Provost, Fellows, Scholars And Other Members Of Board Of Trinity College Dublin Composite viscoelastic hydrogel, and uses thereof for sealing a channel in tissue
US11801324B2 (en) 2018-05-09 2023-10-31 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
WO2020055201A1 (ko) * 2018-09-13 2020-03-19 주식회사 엘지화학 황산화 히알루론산 기반의 하이드로겔 및 이를 포함하는 약제학적 조성물
CN109721744B (zh) * 2018-12-26 2020-06-16 清华大学 一种基于硼酸酯键的自修复抗菌水凝胶
CN109575269B (zh) * 2019-02-02 2020-06-02 清华大学 一种具有双重动态网络的自愈性水凝胶及其制备方法
EP3976123A1 (en) 2019-05-31 2022-04-06 University College Dublin Hyaluronic acid-based hybrid hydrogel
CA3145024A1 (en) 2019-07-03 2021-01-07 Molly Sandra Shoichet Hydrogel compositions and uses thereof
KR20200055645A (ko) * 2019-08-08 2020-05-21 고려대학교 산학협력단 황산화된 히알루론산 유도체, 이의 제조방법 및 이를 포함하는 근골격계 관절질환의 예방 또는 치료용 약학 조성물
US11730691B2 (en) 2019-12-02 2023-08-22 Galderma Holding SA High molecular weight esthetic compositions
CN113024845A (zh) * 2021-03-17 2021-06-25 广西医科大学 一种醛肼交联型抗菌水凝胶敷料的制备方法
TW202333793A (zh) 2022-01-11 2023-09-01 義大利商Ｇｐｑ有限公司 作為創新填充劑之新玻尿酸衍生物
EP4552653A1 (en) 2023-11-07 2025-05-14 Università degli Studi di Catania Hyaluronic acid derivatives photogenerating nitric oxide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2953702B2 (ja) * 1989-01-20 1999-09-27 生化学工業株式会社 合成コンドロイチン硫酸プロテオグリカンを含有する組織癒着防止剤
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid

Also Published As

Publication number Publication date
DE60104703D1 (de) 2004-09-09
AU1387002A (en) 2002-03-13
EP1313772B1 (en) 2004-08-04
ES2227297T3 (es) 2005-04-01
ITPD20000207A1 (it) 2002-03-03
JP2004507588A (ja) 2004-03-11
EP1313772A1 (en) 2003-05-28
CA2423384A1 (en) 2002-03-07
WO2002018450A1 (en) 2002-03-07
DE60104703T2 (de) 2005-07-14
CA2423384C (en) 2009-11-24
ITPD20000207A0 (it) 2000-08-31
US7125860B1 (en) 2006-10-24
ATE272654T1 (de) 2004-08-15
AU2002213870B2 (en) 2005-11-03

Similar Documents

Publication Publication Date Title
IT1317358B1 (it) Derivati cross-linkati dell'acido ialuronico.
Kim et al. Co‐delivery of platelet‐derived growth factor (PDGF‐BB) and bone morphogenic protein (BMP‐2) coated onto heparinized titanium for improving osteoblast function and osteointegration
MXPA05003591A (es) Materiales basados en ciclodextrina, composiciones y usos relacionados a los mismos.
WO2000027887A3 (en) Cross-linked hyaluronic acids and medical uses thereof
WO2004094495A3 (en) Compositions and methods of using a transient colorant
ATE230978T1 (de) Verfahren und zubereitungen zum verbessern der bioadhäsiv-eigenschaften von polymeren unter verwendung organischer excipienten
DE69809892D1 (de) N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung
ATE424848T1 (de) Pharmazeutische zusammensetzungen für die kontrollierte freigabe von biologischen wirkstoffen
IL174561A0 (en) Drug coating providing high drug loading and methods for providing the same
CY1107711T1 (el) Υπογλωσσια χορηγηση φαρμακευτικης συνθεσης ως αγωγη εναντι οξεων διαταραχων
DE69533370D1 (de) Heparinähnliche sulfatierte Polysaccharide
BR9800228A (pt) Compostos de peridilfurano e piridiltiofeno
BRPI0410956A (pt) pelìculas com base em óxido de polietileno e sistemas de liberação de droga feitos delas
IT1306679B1 (it) Uso dei derivati dell'acido ialuronico per la preparazione dicomposizoni farmaceutiche e biomateriali per la prevenzione della
BR9811972A (pt) Formas sólidas de dosagem farmacêutica em forma de uma dispersão particulada
WO2004039428A3 (en) Transdermal delivery system for dried particulate or lyophilized medications
YU75903A (sh) Tiohidantoini i njihovo korišćenje u lečenju dijabetisa
BRPI0203172B8 (pt) composição farmacêutica para acondroplasia
SE9300581L (sv) Komposition för nasalbehandling
JP2006508078A5 (it)
BR9915462A (pt) Processos para preparação de partìculas dedroga revestidas e as suas formulaçõesfarmacêuticas
ATE386725T1 (de) Heterocyclylverbindungen
ATE326955T1 (de) Verfahren zur kontinuierlichen herstellung und beschichtung von selbstklebemassen auf basis von sbc mit mindestens einem pharmazeutischen wirkstoff
BR0009472A (pt) Antagonistas de lhrh com propriedades desolubilidade aperfeiçoadas
CY1106967T1 (el) Παραγωγα πεπτιδιων χαμηλου μοριακου βαρους ως αναστολεις της αλληλεπιδρασης λαμινινης/εντακτινης