IT1265325B1 - Derivati di indolo; procedimenti per la loro preparazione e loro impiego in medicina. - Google Patents

Derivati di indolo; procedimenti per la loro preparazione e loro impiego in medicina.

Info

Publication number: IT1265325B1
Authority: IT; Italy
Prior art keywords: indole; medicine; procedures; derivatives; preparation
Prior art date: 1992-04-16

Application number

IT93RM000236A

Other languages

English (en)

Inventor

Alfredo Cugola

Giovanni Gaviraghi

Original Assignee

Glaxo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-16

Filing date

1993-04-15

Publication date

1996-10-31

1993-04-15 Application filed by Glaxo Spa filed Critical Glaxo Spa

1993-04-15 Publication of ITRM930236A0 publication Critical patent/ITRM930236A0/it

1994-10-15 Publication of ITRM930236A1 publication Critical patent/ITRM930236A1/it

1996-10-31 Application granted granted Critical

1996-10-31 Publication of IT1265325B1 publication Critical patent/IT1265325B1/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

IT93RM000236A 1992-04-16 1993-04-15 Derivati di indolo; procedimenti per la loro preparazione e loro impiego in medicina. IT1265325B1 (it)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929208492A GB9208492D0 (en)	1992-04-16	1992-04-16	Heterocyclic compounds

Publications (3)

Publication Number	Publication Date
ITRM930236A0 ITRM930236A0 (it)	1993-04-15
ITRM930236A1 ITRM930236A1 (it)	1994-10-15
IT1265325B1 true IT1265325B1 (it)	1996-10-31

Family

ID=10714220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT93RM000236A IT1265325B1 (it)	1992-04-16	1993-04-15	Derivati di indolo; procedimenti per la loro preparazione e loro impiego in medicina.

Country Status (41)

Country	Link
US (4)	US5374649A (it)
EP (1)	EP0568136A1 (it)
JP (2)	JPH07505407A (it)
KR (1)	KR100264114B1 (it)
CN (1)	CN1042331C (it)
AP (1)	AP480A (it)
AT (1)	AT403917B (it)
AU (1)	AU666927B2 (it)
BE (1)	BE1006343A5 (it)
BG (1)	BG62136B1 (it)
BR (1)	BR1100323A (it)
CA (3)	CA2094076A1 (it)
CH (1)	CH685630A5 (it)
CY (1)	CY2038B1 (it)
CZ (1)	CZ285799B6 (it)
DK (1)	DK169890B1 (it)
ES (1)	ES2105924B1 (it)
FI (1)	FI106198B (it)
FR (1)	FR2690919B1 (it)
GB (2)	GB9208492D0 (it)
GE (1)	GEP19991704B (it)
GR (1)	GR1001619B (it)
HK (1)	HK95797A (it)
HU (2)	HU217964B (it)
IL (1)	IL105412A (it)
IS (1)	IS3994A (it)
IT (1)	IT1265325B1 (it)
LU (1)	LU88248A1 (it)
MX (1)	MX9302195A (it)
MY (1)	MY112232A (it)
NO (1)	NO301879B1 (it)
NZ (1)	NZ247413A (it)
OA (1)	OA10103A (it)
PL (1)	PL176451B1 (it)
RO (1)	RO113242B1 (it)
RU (1)	RU2129544C1 (it)
SE (1)	SE504336C2 (it)
SK (1)	SK281941B6 (it)
TW (1)	TW224457B (it)
WO (1)	WO1993021153A1 (it)
ZA (1)	ZA932642B (it)

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GB9304500D0 (en) *	1993-03-05	1993-04-21	Glaxo Spa	Heterocyclic compounds
US5519048A (en) *	1993-05-27	1996-05-21	Merrell Pharmaceuticals Inc.	3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
AU681402B2 (en) *	1993-05-27	1997-08-28	Aventis Inc.	3-(indol-3-yl) propenoic acid derivatives and as NMDA antagonists
GB9319243D0 (en) *	1993-09-17	1993-11-03	Glaxo Spa	Heterocyclic compounds
GB9321221D0 (en) *	1993-10-14	1993-12-01	Glaxo Spa	Heterocyclic compounds
TW280819B (it) *	1993-11-17	1996-07-11	Sumitomo Pharma
US5563157B1 (en) *	1994-10-31	1999-02-02	Hoecst Marion Roussel Inc	Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) *	1995-02-11	1995-03-29	Glaxo Spa	Pharmaceutical composition
GB9504361D0 (en) *	1995-03-04	1995-04-26	Glaxo Spa	Heterocyclic compounds
AU4416197A (en) *	1996-09-17	1998-04-14	Regents Of The University Of California, The	Positive ampa receptor modulation to enhance brain neurotrophic factor expression
DE69734594T2 (de) *	1996-09-30	2006-07-06	Aventis Pharmaceuticals Inc.	Nmda (n-methyl-d-aspartate) antagonists
US5922752A (en) *	1997-06-11	1999-07-13	Hoechst Marion Roussell, Inc.	NMDA (n-methyl-d-aspartate) antagonists
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PA8579701A1 (es) *	2002-08-23	2005-05-24	Pfizer Prod Inc	Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) *	2003-02-13	2004-08-26	Grünenthal GmbH	Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
JP2006526612A (ja) *	2003-06-05	2006-11-24	ファイザー・プロダクツ・インク	ベータ−ラクタマーゼ阻害剤・プロドラッグ
CA2547283C (en) *	2003-11-26	2010-11-09	Pfizer Products Inc.	Aminopyrazole derivatives as gsk-3 inhibitors
CZ2006427A3 (cs) *	2003-12-29	2006-11-15	Sepracor Inc.	Pyrrolové a pyrazolové inhibitory DAAO
US20060002999A1 (en) *	2004-06-17	2006-01-05	Forest Laboratories, Inc.	Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
CN101553217A (zh)	2005-07-06	2009-10-07	塞普拉科公司	艾司佐匹克隆与反式4－(3,4－二氯苯基)－1,2,3,4－四氢－n－甲基－1－萘胺或反式4－(3,4－二氯苯基)－1,2,3,4－四氢－1－萘胺的组合以及治疗绝经期和心境障碍、焦虑症和认知障碍的方法
BRPI0706365A2 (pt)	2006-01-06	2011-03-22	Sepracor Inc	Cicloalquilaminas como inibidores da recaptação de monoamina
CA2636275C (en)	2006-01-06	2013-02-12	Sepracor Inc.	Tetralone-based monoamine reuptake inhibitors
PT2013835E (pt)	2006-03-31	2016-01-06	Sunovion Pharmaceuticals Inc	Preparação de amidas and aminas quirais
US7579370B2 (en) *	2006-06-30	2009-08-25	Sepracor Inc.	Fused heterocycles
US7884124B2 (en) *	2006-06-30	2011-02-08	Sepracor Inc.	Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) *	2006-10-02	2008-04-03	Weyerhaeuser Co.	Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en)	2006-12-20	2008-07-09	sanofi-aventis	Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
US7902252B2 (en) *	2007-01-18	2011-03-08	Sepracor, Inc.	Inhibitors of D-amino acid oxidase
US20090099248A1 (en) *	2007-01-18	2009-04-16	Sepracor Inc.	Inhibitors of d-amino acid oxidase
BRPI0811639A2 (pt)	2007-05-31	2014-09-30	Sepracor Inc	Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina
US20090247644A1 (en) *	2008-03-28	2009-10-01	Forest Laboratories Holdings Limited	Memantine formulations
US20100120740A1 (en) *	2008-08-07	2010-05-13	Sepracor Inc.	Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
EP2407454A4 (en) *	2009-03-10	2012-05-30	Santen Pharmaceutical Co Ltd	PROPHYLACTIC OR THERAPEUTIC AGENT FOR OPTICAL NERVE DISORDERS COMPRISING A DERIVATIVE OR SALT OF 4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID AS ACTIVE INGREDIENT
US20110034434A1 (en) *	2009-08-07	2011-02-10	Sepracor Inc.	Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en)	2012-07-12	2017-08-22	Glytech, Llc	Composition and method for treatment of depression and psychosis in humans
AU2015253099B2 (en)	2014-04-30	2019-07-18	National Chiao Tung University	Use of known compounds as D-amino acid oxidase inhibitors
CN110234635B (zh)	2016-09-14	2023-03-10	宇凤·简·曾	作为d-胺基酸氧化酶(daao)抑制剂之新颖经取代苯并咪唑衍生物
AU2018284335A1 (en)	2017-06-12	2020-01-30	Glytech Llc.	Treatment of depression with NMDA antagonists and D2/5HT2A or selective 5HT2A antagonists
CN112707874A (zh) *	2020-12-29	2021-04-27	广东中科药物研究有限公司	一种抗病毒化合物及其制备方法

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HU216787B (hu) *	1990-07-16	1999-08-30	Merrell Dow Pharmaceuticals Inc.	Eljárás excitátoros aminosav-antagonista hatású indolszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5284862A (en) *	1991-03-18	1994-02-08	Warner-Lambert Company	Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) *	1991-05-14	1992-09-08	Warner-Lambert Co.	Substituted 2-carboxylindoles having pharmaceutical activity

1992
- 1992-04-16 GB GB929208492A patent/GB9208492D0/en active Pending
1993
- 1993-04-14 ZA ZA932642A patent/ZA932642B/xx unknown
- 1993-04-15 IT IT93RM000236A patent/IT1265325B1/it active IP Right Grant
- 1993-04-15 US US08/047,430 patent/US5374649A/en not_active Expired - Fee Related
- 1993-04-15 CA CA002094076A patent/CA2094076A1/en not_active Abandoned
- 1993-04-15 DK DK043193A patent/DK169890B1/da active
- 1993-04-15 BE BE9300371A patent/BE1006343A5/fr active
- 1993-04-15 IL IL105412A patent/IL105412A/en not_active IP Right Cessation
- 1993-04-15 MX MX9302195A patent/MX9302195A/es not_active IP Right Cessation
- 1993-04-15 US US08/046,947 patent/US5373018A/en not_active Expired - Fee Related
- 1993-04-15 CZ CZ942543A patent/CZ285799B6/cs not_active IP Right Cessation
- 1993-04-15 WO PCT/EP1993/000938 patent/WO1993021153A1/en active IP Right Grant
- 1993-04-15 ES ES09300771A patent/ES2105924B1/es not_active Expired - Lifetime
- 1993-04-15 GR GR930100154A patent/GR1001619B/el not_active IP Right Cessation
- 1993-04-15 CA CA002094073A patent/CA2094073A1/en not_active Abandoned
- 1993-04-15 RU RU94045915A patent/RU2129544C1/ru active
- 1993-04-15 JP JP5517997A patent/JPH07505407A/ja active Pending
- 1993-04-15 FR FR9304452A patent/FR2690919B1/fr not_active Expired - Fee Related
- 1993-04-15 AU AU36923/93A patent/AU666927B2/en not_active Ceased
- 1993-04-15 SK SK1241-94A patent/SK281941B6/sk unknown
- 1993-04-15 AT AT0075293A patent/AT403917B/de not_active IP Right Cessation
- 1993-04-15 KR KR1019940703668A patent/KR100264114B1/ko not_active IP Right Cessation
- 1993-04-15 CH CH1133/93A patent/CH685630A5/fr not_active IP Right Cessation
- 1993-04-15 US US08/047,429 patent/US5374648A/en not_active Expired - Fee Related
- 1993-04-15 SE SE9301241A patent/SE504336C2/sv not_active IP Right Cessation
- 1993-04-15 IS IS3994A patent/IS3994A/is unknown
- 1993-04-15 HU HU9402975A patent/HU217964B/hu not_active IP Right Cessation
- 1993-04-15 LU LU88248A patent/LU88248A1/fr unknown
- 1993-04-15 EP EP93201103A patent/EP0568136A1/en not_active Withdrawn
- 1993-04-15 RO RO94-01658A patent/RO113242B1/ro unknown
- 1993-04-15 PL PL93305554A patent/PL176451B1/pl unknown
- 1993-04-15 NZ NZ247413A patent/NZ247413A/en unknown
- 1993-04-15 MY MYPI93000690A patent/MY112232A/en unknown
- 1993-04-15 GB GB9307808A patent/GB2266091B/en not_active Expired - Fee Related
- 1993-04-15 JP JP5088844A patent/JPH0649027A/ja active Pending
- 1993-04-15 CA CA002094075A patent/CA2094075A1/en not_active Abandoned
- 1993-04-15 CN CN93105797A patent/CN1042331C/zh not_active Expired - Fee Related
- 1993-04-16 GE GEAP19932602A patent/GEP19991704B/en unknown
- 1993-04-16 AP APAP/P/1993/000524A patent/AP480A/en active
- 1993-05-06 TW TW082103531A patent/TW224457B/zh active
1994
- 1994-10-10 OA OA60570A patent/OA10103A/en unknown
- 1994-10-12 FI FI944800A patent/FI106198B/fi active
- 1994-10-14 BG BG99111A patent/BG62136B1/bg unknown
- 1994-10-14 NO NO943913A patent/NO301879B1/no not_active IP Right Cessation
- 1994-12-08 US US08/351,762 patent/US5510367A/en not_active Expired - Fee Related
1995
- 1995-06-29 HU HU95P/P00538P patent/HU211826A9/hu unknown
1997
- 1997-04-22 BR BR1100323-5A patent/BR1100323A/pt active IP Right Grant
- 1997-06-26 HK HK95797A patent/HK95797A/xx not_active IP Right Cessation
1998
- 1998-04-30 CY CY9802038A patent/CY2038B1/xx unknown

Also Published As

Publication number	Publication date
ZA932642B (en)	1994-01-10
WO1993021153A1 (en)	1993-10-28
US5510367A (en)	1996-04-23
GB9307808D0 (en)	1993-06-02
JPH0649027A (ja)	1994-02-22
ES2105924B1 (es)	1998-07-01
DK169890B1 (da)	1995-03-27
IS3994A (is)	1993-10-17
RO113242B1 (ro)	1998-05-29
IL105412A (en)	1998-02-22
CA2094073A1 (en)	1993-10-17
GEP19991704B (en)	1999-08-05
TW224457B (it)	1994-06-01
SE504336C2 (sv)	1997-01-13
AU3692393A (en)	1993-10-21
US5374649A (en)	1994-12-20
EP0568136A1 (en)	1993-11-03
SK281941B6 (sk)	2001-09-11
HU9402975D0 (en)	1995-02-28
SE9301241L (sv)	1993-10-17
CN1042331C (zh)	1999-03-03
MX9302195A (es)	1994-03-31
LU88248A1 (fr)	1994-03-01
FI944800A0 (fi)	1994-10-12
NO943913L (no)	1994-12-14
IL105412A0 (en)	1993-08-18
AT403917B (de)	1998-06-25
CY2038B1 (en)	1998-04-30
DK43193A (da)	1993-10-17
HUT70526A (en)	1995-10-30
RU2129544C1 (ru)	1999-04-27
NZ247413A (en)	1995-12-21
ES2105924A1 (es)	1997-10-16
BE1006343A5 (fr)	1994-07-26
HK95797A (en)	1997-08-08
CN1085212A (zh)	1994-04-13
ITRM930236A0 (it)	1993-04-15
HU217964B (hu)	2000-05-28
FI106198B (fi)	2000-12-15
GB2266091A (en)	1993-10-20
SE9301241D0 (sv)	1993-04-15
US5373018A (en)	1994-12-13
ATA75293A (de)	1997-11-15
NO943913D0 (no)	1994-10-14
HU211826A9 (en)	1995-12-28
GB9208492D0 (en)	1992-06-03
ITRM930236A1 (it)	1994-10-15
FI944800A (fi)	1994-10-12
BG62136B1 (bg)	1999-03-31
BG99111A (bg)	1995-05-31
CZ254394A3 (en)	1995-07-12
AP9300524A0 (en)	1993-04-30
PL176451B1 (pl)	1999-05-31
MY112232A (en)	2001-05-31
GB2266091B (en)	1995-08-09
RU94045915A (ru)	1996-09-10
OA10103A (en)	1996-12-18
FR2690919B1 (fr)	1995-05-05
NO301879B1 (no)	1997-12-22
CH685630A5 (fr)	1995-08-31
AU666927B2 (en)	1996-02-29
AP480A (en)	1996-03-22
GR1001619B (el)	1994-07-29
CA2094076A1 (en)	1993-10-17
FR2690919A1 (fr)	1993-11-12
BR1100323A (pt)	2000-06-27
CA2094075A1 (en)	1993-10-17
JPH07505407A (ja)	1995-06-15
US5374648A (en)	1994-12-20
KR100264114B1 (ko)	2000-11-01
SK124194A3 (en)	1995-05-10
CZ285799B6 (cs)	1999-11-17
DK43193D0 (da)	1993-04-15

Publication	Publication Date	Title
IT1265325B1 (it)	1996-10-31	Derivati di indolo; procedimenti per la loro preparazione e loro impiego in medicina.
ITMI920528A0 (it)	1992-03-06	14-beta idrossi-10-de acetil-baccatina iii, suoi derivati, loro preparazione ed impiego terapeutico
IT1217327B (it)	1990-03-22	Metodo per la preparazione di derivati gangliosidici e loro uso in preparazioni farmaceutiche
ES2171158T3 (es)	2002-09-01	Derivados de oxatiolano cristalizados.
NZ241211A (en)	1993-08-26	16alpha,17alpha-alkylidenedioxy-11b,21-dihydroxypregan -4-ene-3,20-dione derivatives substituted by halogen in either or both of the 6alpha- or the 9alpha- position; pharmaceutical compositions, methods of preparation and treatment
ITTO920325A0 (it)	1992-04-09	Nuovi derivati basici dell'acido glutammico ed acido aspartico, proce-dimento per la loro preparazione e loro uso farmaceutico.
IT1229523B (it)	1991-09-04	Derivati isochinolinici, procedimento per la loro preparazione ed impiego
NO940027L (no)	1994-01-04	Fremgangsmaate for fremstilling av derivater av B-fenylisorerin og derivatenes anvendelse
ITMI910080A1 (it)	1992-07-15	Derivati arilvinilamidici e procedimento per la loro preparazione
ITMI922779A1 (it)	1994-06-04	Antagonisti delle tachichinine, procedimento per la loro preparazione e loro impiego in formulazioni farmaceutiche
IT1229491B (it)	1991-09-03	Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali
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