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IN2014DN10991A - - Google Patents

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Publication number
IN2014DN10991A
IN2014DN10991A IN10991DEN2014A IN2014DN10991A IN 2014DN10991 A IN2014DN10991 A IN 2014DN10991A IN 10991DEN2014 A IN10991DEN2014 A IN 10991DEN2014A IN 2014DN10991 A IN2014DN10991 A IN 2014DN10991A
Authority
IN
India
Prior art keywords
cells
methods
genes encoding
target
genes
Prior art date
Application number
Inventor
Roman Galetto
Agnes Gouble
Stephanie Grosse
Cecile Mannioui
Laurent Poirot
Andrew Scharenberg
Julianne Smith
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48579464&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN10991(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellectis filed Critical Cellectis
Publication of IN2014DN10991A publication Critical patent/IN2014DN10991A/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
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Abstract

Methods for developing engineered T cells for immunotherapy that are both non alloreactive and resistant to immunosuppressive drugs. The present invention relates to methods for modifying T cells by inactivating both genes encoding target for an immunosuppressive agent and T cell receptor in particular genes encoding CD52 and TCR. This method involves the use of specific rare cutting endonucleases in particular TALE nucleases (TAL effector endonuclease) and polynucleotides encoding such polypeptides to precisely target a selection of key genes in T cells which are available from donors or from culture of primary cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer and viral infections.
IN10991DEN2014 2012-05-25 2013-05-13 IN2014DN10991A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261651933P 2012-05-25 2012-05-25
US201261696612P 2012-09-04 2012-09-04
PCT/US2013/040755 WO2013176915A1 (en) 2012-05-25 2013-05-13 Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy

Publications (1)

Publication Number Publication Date
IN2014DN10991A true IN2014DN10991A (en) 2015-09-25

Family

ID=48579464

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10991DEN2014 IN2014DN10991A (en) 2012-05-25 2013-05-13

Country Status (25)

Country Link
US (15) US10426795B2 (en)
EP (6) EP3279315A3 (en)
JP (5) JP6463671B2 (en)
KR (2) KR102247979B1 (en)
CN (3) CN108998418A (en)
AR (1) AR096274A1 (en)
AU (5) AU2013266734B2 (en)
BR (1) BR112014029417B1 (en)
CA (3) CA2874611C (en)
DK (1) DK2855667T5 (en)
EA (1) EA201492222A1 (en)
ES (1) ES2962571T3 (en)
HK (2) HK1208879A1 (en)
HU (1) HUE064187T2 (en)
IN (1) IN2014DN10991A (en)
MA (1) MA37681B2 (en)
MX (1) MX370265B (en)
MY (1) MY180127A (en)
NZ (1) NZ703281A (en)
PL (1) PL2855667T3 (en)
PT (1) PT2855667T (en)
SG (2) SG10201806573TA (en)
UA (1) UA118652C2 (en)
WO (2) WO2013176916A1 (en)
ZA (1) ZA201409536B (en)

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AU2012333134B2 (en) 2011-07-22 2017-05-25 John Paul Guilinger Evaluation and improvement of nuclease cleavage specificity
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US20150017136A1 (en) * 2013-07-15 2015-01-15 Cellectis Methods for engineering allogeneic and highly active t cell for immunotherapy
DK2855667T5 (en) 2012-05-25 2024-10-14 Cellectis Methods for manipulation of allogeneic and immunosuppressant-resistant T cells for immunotherapy
DK2906684T3 (en) * 2012-10-10 2020-09-28 Sangamo Therapeutics Inc T-CELL MODIFIING COMPOUNDS AND USES THEREOF
KR20210147101A (en) 2013-02-15 2021-12-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Chimeric Antigen Receptor and Methods of Use Thereof
US9499855B2 (en) 2013-03-14 2016-11-22 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
US9587237B2 (en) 2013-03-14 2017-03-07 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
KR20150131218A (en) * 2013-03-14 2015-11-24 벨리쿰 파마슈티컬스, 인크. Methods for controlling t cell proliferation
JP6005572B2 (en) * 2013-03-28 2016-10-12 Kddi株式会社 Moving picture encoding apparatus, moving picture decoding apparatus, moving picture encoding method, moving picture decoding method, and program
PT2981607T (en) 2013-04-03 2020-11-20 Memorial Sloan Kettering Cancer Center Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
US20230050345A1 (en) * 2013-05-13 2023-02-16 Cellectis Methods for engineering allogeneic and highly active t cell for immunotheraphy
US11311575B2 (en) * 2013-05-13 2022-04-26 Cellectis Methods for engineering highly active T cell for immunotherapy
US11077144B2 (en) 2013-05-13 2021-08-03 Cellectis CD19 specific chimeric antigen receptor and uses thereof
US20230056268A1 (en) * 2013-05-13 2023-02-23 Cellectis Methods for engineering highly active t cell for immunotheraphy
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