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IN2012DN00605A - - Google Patents

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Publication number
IN2012DN00605A
IN2012DN00605A IN605DEN2012A IN2012DN00605A IN 2012DN00605 A IN2012DN00605 A IN 2012DN00605A IN 605DEN2012 A IN605DEN2012 A IN 605DEN2012A IN 2012DN00605 A IN2012DN00605 A IN 2012DN00605A
Authority
IN
India
Prior art keywords
4alkyl
hydrogen
taken together
dioxolane
alkyl
Prior art date
Application number
Inventor
R Pendri Yadagiri
H Chen Chung-Pin
S Patel Sunil
M Evans Jeffrey
Liang Jing
R Kronenthal David
L Powers Gerald
Josyula Prasad Siva
T Bien Jeffrey
Shi Zhongping
N Patel Ramesh
Banerjee Amit
Y Chan Yeung
K Rijhwani Sushil
K Singh Ambarish
Wang Shaopeng
Stojanovic Milan
J Kucera David
Polniaszek Richard
Lewis Charles
Thottathil John
Krishnamurty Dhileepkumar
X Zhou Maotang
Vemishetti Purushotham
Original Assignee
Bristol Mayers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Mayers Squibb Company filed Critical Bristol Mayers Squibb Company
Publication of IN2012DN00605A publication Critical patent/IN2012DN00605A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/083—Syntheses without formation of a Si-C bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
    • C07F7/0827—Syntheses with formation of a Si-C bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A compound of formula: or a salt thereof wherein: Ra is alkyl, phenyl, C1 to C6 alkylphenyl, or C1 to C6 alkoxyphenyl; Rb is C1 to C6 alkyl; R20 is hydrogen or benzyl; X is C1, I, or benzyloxy; Ry and Rz are taken together to form, methylene (=CH2), or Ry is OR23, and Rz is -CH2OR24, wherein R23 and R24 are each hydrogen or are taken together to form a ting to define a dioxolane, said dioxolane being optionally substituted with -O(C1-4alkyl) or-O(C=O)( C1-4alkyl); and R25 and R26 are both hydrogen, or one of R23 and R26 is hydrogen and the other is acyl; or R25 and R26are taken together to form =CH(OC1-4alkyl) or =CH(OC(=O)C1-4alkyl).
IN605DEN2012 2002-12-11 2003-12-10 IN2012DN00605A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43254902P 2002-12-11 2002-12-11
PCT/US2003/039554 WO2004052310A2 (en) 2002-12-11 2003-12-10 Process and intermediates for synthesis entecavir

Publications (1)

Publication Number Publication Date
IN2012DN00605A true IN2012DN00605A (en) 2015-06-12

Family

ID=32507962

Family Applications (3)

Application Number Title Priority Date Filing Date
IN604DEN2012 IN2012DN00604A (en) 2002-12-11 2003-12-10
IN605DEN2012 IN2012DN00605A (en) 2002-12-11 2003-12-10
IN606DEN2012 IN2012DN00606A (en) 2002-12-11 2003-12-10

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IN604DEN2012 IN2012DN00604A (en) 2002-12-11 2003-12-10

Family Applications After (1)

Application Number Title Priority Date Filing Date
IN606DEN2012 IN2012DN00606A (en) 2002-12-11 2003-12-10

Country Status (18)

Country Link
US (3) US7034152B2 (en)
EP (2) EP2433941A1 (en)
JP (2) JP4726491B2 (en)
KR (2) KR101096830B1 (en)
CN (6) CN101899063B (en)
AU (1) AU2003300884B2 (en)
BR (2) BRPI0317255B8 (en)
CA (2) CA2735485A1 (en)
DK (1) DK1644384T3 (en)
ES (1) ES2397104T3 (en)
IL (1) IL168691A (en)
IN (3) IN2012DN00604A (en)
MX (1) MXPA05005971A (en)
PL (2) PL397715A1 (en)
PT (1) PT1644384E (en)
SI (1) SI1644384T1 (en)
TW (1) TWI327568B (en)
WO (1) WO2004052310A2 (en)

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DE60313173T2 (en) * 2002-06-27 2008-01-03 F. Hoffmann-La Roche Ag SYNTHESIS OF PURIN DERIVATIVES
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US7511139B2 (en) * 2004-06-04 2009-03-31 Bristol-Myers Squibb Company Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
TW200540175A (en) * 2004-06-04 2005-12-16 Bristol Myers Squibb Co Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation
CN100379736C (en) * 2005-05-13 2008-04-09 上海仲夏化学有限公司 Preparation process of entecavir
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CN101863842B (en) * 2006-08-24 2012-02-01 江苏正大天晴药业股份有限公司 Entecavir midbodies and synthesis method
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CN101284799B (en) 2007-03-23 2013-04-03 浙江医药股份有限公司新昌制药厂 Nitrogen-contained derivates of caffeoylquinic acid, method for preparing same, pharmaceutical compositions thereof and uses
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EP1644384A4 (en) 2009-09-02
KR20050087831A (en) 2005-08-31
BR0317255A (en) 2005-11-08
CA2735485A1 (en) 2004-06-24
US7541460B2 (en) 2009-06-02
EP1644384B1 (en) 2012-10-31
PL212790B1 (en) 2012-11-30
IL168691A (en) 2011-09-27
CN101899063B (en) 2012-12-12
CN100379746C (en) 2008-04-09
SI1644384T1 (en) 2013-02-28
PL377263A1 (en) 2006-01-23
CN102675355B (en) 2015-05-06
US20040192912A1 (en) 2004-09-30
TWI327568B (en) 2010-07-21
TW200504065A (en) 2005-02-01
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