IL88531A - Cognitive enhancing compositions containing d-cycloserine - Google Patents

Cognitive enhancing compositions containing d-cycloserine

Info

Publication number: IL88531A
Authority: IL; Israel
Prior art keywords: cycloserine; compositions containing; enhancing compositions; cognitive enhancing; cognitive
Prior art date: 1987-12-01

Application number

IL88531A

Other languages

English (en)

Other versions

IL88531A0 (en

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-01

Filing date

1988-11-29

Publication date

1993-02-21

1988-11-29 Application filed by Searle & Co filed Critical Searle & Co

1989-06-30 Publication of IL88531A0 publication Critical patent/IL88531A0/xx

1993-02-21 Publication of IL88531A publication Critical patent/IL88531A/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Psychiatry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL88531A 1987-12-01 1988-11-29 Cognitive enhancing compositions containing d-cycloserine IL88531A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/127,121 US4904681A (en)	1987-12-01	1987-12-01	D-cycloserine and its prodrugs as cognitive enhancers

Publications (2)

Publication Number	Publication Date
IL88531A0 IL88531A0 (en)	1989-06-30
IL88531A true IL88531A (en)	1993-02-21

Family

ID=22428413

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL88531A IL88531A (en)	1987-12-01	1988-11-29	Cognitive enhancing compositions containing d-cycloserine

Country Status (20)

Country	Link
US (1)	US4904681A (xx)
EP (2)	EP0319824B1 (xx)
JP (2)	JPH0621065B2 (xx)
KR (1)	KR0134198B1 (xx)
AT (1)	ATE68698T1 (xx)
AU (4)	AU622630B2 (xx)
CA (1)	CA1328617C (xx)
DE (1)	DE3865817D1 (xx)
DK (1)	DK173589B1 (xx)
ES (1)	ES2040314T3 (xx)
FI (1)	FI885559A0 (xx)
GR (1)	GR3003571T3 (xx)
IE (1)	IE61825B1 (xx)
IL (1)	IL88531A (xx)
NO (1)	NO885337D0 (xx)
NZ (1)	NZ227131A (xx)
PH (1)	PH26467A (xx)
PT (1)	PT89109B (xx)
WO (1)	WO1989005144A1 (xx)
ZA (1)	ZA888981B (xx)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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US5187171A (en) *	1989-01-09	1993-02-16	G. D. Searle & Co.	Use of a glycine b partial agonist as an antipsychotic
US5061721A (en) *	1989-03-15	1991-10-29	G. D. Searle & Co.	Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder
US5260324A (en) *	1990-02-06	1993-11-09	G. D. Searle & Company	Composition containing D-cycloserine and D-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder
US5066665A (en) *	1990-05-21	1991-11-19	Warner-Lambert Co.	Substituted isoxazolidin-3-ones and derivatives thereof acting at muscarinic receptors
JPH07505908A (ja) *	1992-09-28	1995-06-29	マックセチーニ、マリア　ルイザ	Ｎｍｄａ受容体のアロステリックモジュレーター
US5428069A (en) *	1993-01-11	1995-06-27	The United States Of America As Represented By The Department Of Health & Human Services	Treating cognition with, aminocyclopropanecarboxylic derivatives
US5523323A (en) *	1993-09-14	1996-06-04	Maccecchini; Maria-Luisa	Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence
NZ260302A (en) *	1994-04-13	1996-05-28	New Zealand Meat Ind Res Inst	Treating bait aversion by including substances which disrupt the associative learning process into bait compositions
AU4019395A (en)	1994-11-23	1996-06-17	G.D. Searle & Co.	Use of amino-isoxazolidone compounds for improvement of implicit memory
AU4128896A (en) *	1994-11-23	1996-06-17	G.D. Searle & Co.	Use of amino-isoxazolidone compounds for treatment of memory impairment following traumatic brain injury
CA2216648A1 (en) *	1995-02-15	1996-08-22	Bearsden Bio, Inc.	Alkylcarboxy amino acids-modulators of the kainate receptor
US6355681B2 (en) *	1995-12-07	2002-03-12	Glytech, Inc.	Glycine substitutes and precursors for treating a psychosis
IL124536A (en) *	1995-12-07	2001-03-19	Daniel C Javitt	Pharmaceutical compositions containing a glycine uptake antagonist
US6361957B1 (en) *	1999-08-03	2002-03-26	Glytech, Inc.	Assay for D-serine transport antagonist and use for treating psychosis
FR2742748B1 (fr) *	1995-12-21	1998-01-30	Adir	Nouveau derive de 4-imidazolidinone, son procede de preparation et les compositions pharmaceutiques qui le contiennent
KR100396114B1 (ko) *	1996-10-31	2003-11-20	동아제약 주식회사	D-시클로세린의 제조방법
NZ508160A (en) *	1998-04-14	2004-01-30	Gen Hospital Corp	Methods for treating neuropsychiatric disorders
DE69930624T2 (de) *	1998-06-10	2006-09-14	Meiji Seika Kaisha Ltd.	Arzneimittel für hinterstrangataxie und zusammensetzung zur behandlung von hinterstrangataxie
US20040122090A1 (en) *	2001-12-07	2004-06-24	Lipton Stuart A.	Methods for treating neuropsychiatric disorders with nmda receptor antagonists
US20060252761A1 (en) *	2001-03-29	2006-11-09	Michael Davis	Augmentation of extinction via administration of sub-antimicrobial doses of D-cycloserine
JP2004530666A (ja) *	2001-03-29	2004-10-07	エモリー　ユニバーシティ	学習または条件付けのエンハンサーを用いる精神療法の急性薬理学的増強
EP1389181A4 (en) *	2001-04-02	2005-10-19	Panorama Res Inc	ANTIOXIDANT NITROXIDES AND NITRONES AS THERAPEUTIC AGENTS
US7160913B2 (en) *	2002-09-13	2007-01-09	Thomas Jefferson University	Methods and kit for treating Parkinson's disease
EP2260844A1 (en) *	2003-05-27	2010-12-15	Merz Pharma GmbH & Co. KGaA	Combination of an NMDA Receptor Antagonist and a Selective Serotonin Reuptake Inhibitor for the Treatment of Depression and other Mood Disorders
WO2005014797A2 (en) *	2003-08-08	2005-02-17	The Burnham Institute	P16 mediated regulation of nmda receptors
US7619007B2 (en)	2004-11-23	2009-11-17	Adamas Pharmaceuticals, Inc.	Method and composition for administering an NMDA receptor antagonist to a subject
EP2243475B1 (en)	2005-04-06	2016-01-13	Adamas Pharmaceuticals, Inc.	Combination of memantine and donepezil for treatment of CNS disorders
JP5702288B2 (ja)	2008-09-18	2015-04-15	ノースウエスタンユニバーシティ	Ｎｍｄａレセプターモジュレータ及びその用途
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
US8951968B2 (en)	2009-10-05	2015-02-10	Northwestern University	Methods of treating depression and other related diseases
SG10201501050RA (en)	2010-02-11	2015-04-29	Univ Northwestern	Secondary Structure Stabilized NMDA Receptor Modulators And Uses Thereof
KR101692275B1 (ko)	2010-02-11	2017-01-04	노오쓰웨스턴 유니버시티	２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
WO2014120783A1 (en)	2013-01-29	2014-08-07	Naurex, Inc.	Spiro-lactam nmda receptor modulators and uses thereof
MX2015009772A (es)	2013-01-29	2016-05-31	Aptinyx Inc	Moduladores de receptores nmda de espiro-lactama y sus usos.
BR112015018094A2 (pt)	2013-01-29	2017-07-18	Naurex Inc	moduladores de receptor nmda de espiro-lactama e usos dos mesmos
CA2898863A1 (en)	2013-01-29	2014-08-07	Naurex, Inc.	Spiro-lactam nmda receptor modulators and uses thereof
CA2899010A1 (en)	2013-01-29	2014-08-07	Naurex, Inc.	Spiro-lactam nmda receptor modulators and uses thereof
WO2017201285A1 (en)	2016-05-19	2017-11-23	Aptinyx Inc.	Spiro-lactam nmda receptor modulators and uses thereof
AU2017267708B2 (en)	2016-05-19	2020-02-20	Aptinyx Inc.	Spiro-lactam NMDA receptor modulators and uses thereof
IL264496B (en)	2016-08-01	2022-09-01	Aptinyx Inc	Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
CN109937204B (zh)	2016-08-01	2022-11-25	阿普廷伊克斯股份有限公司	螺-内酰胺nmda受体调节剂及其用途
EP3490974B1 (en)	2016-08-01	2023-12-06	Tenacia Biotechnology (Hong Kong) Co., Limited	Spiro-lactam nmda receptor modulators and uses thereof
WO2018026782A1 (en)	2016-08-01	2018-02-08	Aptinyx Inc.	Spiro-lactam nmda receptor modulators and uses thereof
KR102538803B1 (ko)	2016-08-01	2023-06-01	앱티닉스 인크.	스피로-락탐 nmda 조정제 및 그의 사용 방법
EP3427729A1 (en)	2017-07-13	2019-01-16	Paris Sciences et Lettres - Quartier Latin	Probenecid for use in treating epileptic diseases, disorders or conditions
CN112204031B (zh)	2018-01-31	2024-05-24	元羿生物科技(香港)有限公司	螺-内酰胺nmda受体调节剂及其用途
US12012413B2 (en)	2019-11-11	2024-06-18	Tenacia Biotechnology (Hong Kong) Co., Limited	Methods of treating painful diabetic peripheral neuropathy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3050800C2 (xx) *	1979-03-22	1989-06-22	Continental Pharma Inc., Bruessel/Bruxelles, Be

1987
- 1987-12-01 US US07/127,121 patent/US4904681A/en not_active Expired - Lifetime
1988
- 1988-11-28 PH PH37866A patent/PH26467A/en unknown
- 1988-11-29 PT PT89109A patent/PT89109B/pt not_active IP Right Cessation
- 1988-11-29 ES ES88119863T patent/ES2040314T3/es not_active Expired - Lifetime
- 1988-11-29 EP EP88119863A patent/EP0319824B1/en not_active Expired - Lifetime
- 1988-11-29 AU AU26319/88A patent/AU622630B2/en not_active Ceased
- 1988-11-29 IL IL88531A patent/IL88531A/xx not_active IP Right Cessation
- 1988-11-29 DE DE88119863T patent/DE3865817D1/de not_active Expired - Fee Related
- 1988-11-29 IE IE356788A patent/IE61825B1/en not_active IP Right Cessation
- 1988-11-29 NZ NZ227131A patent/NZ227131A/xx unknown
- 1988-11-29 AT AT88119863T patent/ATE68698T1/de not_active IP Right Cessation
- 1988-11-30 NO NO885337A patent/NO885337D0/no unknown
- 1988-11-30 DK DK198806690A patent/DK173589B1/da not_active IP Right Cessation
- 1988-11-30 FI FI885559A patent/FI885559A0/fi not_active Application Discontinuation
- 1988-11-30 CA CA000584621A patent/CA1328617C/en not_active Expired - Fee Related
- 1988-11-30 ZA ZA888981A patent/ZA888981B/xx unknown
- 1988-11-30 JP JP63303873A patent/JPH0621065B2/ja not_active Expired - Lifetime
- 1988-11-30 KR KR1019880015895A patent/KR0134198B1/ko not_active IP Right Cessation
- 1988-12-01 AU AU28130/89A patent/AU2813089A/en not_active Abandoned
- 1988-12-01 EP EP89900543A patent/EP0421997A1/en not_active Withdrawn
- 1988-12-01 WO PCT/US1988/004244 patent/WO1989005144A1/en not_active Application Discontinuation
1992
- 1992-01-15 GR GR910401170T patent/GR3003571T3/el unknown
- 1992-02-10 AU AU10839/92A patent/AU1083992A/en not_active Abandoned
- 1992-07-03 JP JP4177094A patent/JPH05201859A/ja active Pending
1994
- 1994-10-26 AU AU77467/94A patent/AU7746794A/en not_active Abandoned

Also Published As

Publication number	Publication date
AU7746794A (en)	1995-01-05
IE61825B1 (en)	1994-11-30
GR3003571T3 (xx)	1993-03-16
PT89109B (pt)	1993-07-30
ZA888981B (en)	1990-01-31
AU622630B2 (en)	1992-04-16
NZ227131A (en)	1991-09-25
JPH05201859A (ja)	1993-08-10
PH26467A (en)	1992-07-27
ATE68698T1 (de)	1991-11-15
NO885337D0 (no)	1988-11-30
DK173589B1 (da)	2001-04-02
PT89109A (pt)	1989-12-29
DE3865817D1 (xx)	1991-11-28
KR890009392A (ko)	1989-08-01
CA1328617C (en)	1994-04-19
EP0319824B1 (en)	1991-10-23
DK669088A (da)	1989-06-02
IL88531A0 (en)	1989-06-30
FI885559A0 (fi)	1988-11-30
DK669088D0 (da)	1988-11-30
IE883567L (en)	1989-06-01
JPH01193220A (ja)	1989-08-03
JPH0621065B2 (ja)	1994-03-23
EP0319824A1 (en)	1989-06-14
ES2040314T3 (es)	1995-04-01
AU2813089A (en)	1989-07-05
US4904681A (en)	1990-02-27
EP0421997A1 (en)	1991-04-17
KR0134198B1 (ko)	1998-04-21
WO1989005144A1 (en)	1989-06-15
AU2631988A (en)	1989-06-01
AU1083992A (en)	1992-05-07

Publication	Publication Date	Title
IL88531A (en)	1993-02-21	Cognitive enhancing compositions containing d-cycloserine
TW218869B (xx)	1994-01-11
DE3779053D1 (xx)	1992-06-17
EP0563345A4 (en)	1994-09-28	Novel 4-arylpiperazines and 4-arylpiperidines
EG18729A (en)	1994-10-30	Compound of n- amino - 1,2,4-triazinones used as insecticide.
ZA933497B (en)	1993-12-14	New 7beta-substituted-4-aza-4alpha-androstan-3-ones as 5alpha-reductase inhibitors
IL128425A0 (en)	2000-01-31	Taxane derivatives their preparation and pharmaceutical compositions containing them
GR3007513T3 (xx)	1993-08-31
ZA933496B (en)	1993-12-22	New 7betabsubstituted-4-aza-5alpha-cholestan-3-ones as 5alpha-reductase inhibitors
ES8704931A1 (es)	1987-04-16	Un procedimiento para la preparacion de derivados de piridimilmidazolidiona.
NO174807C (xx)	1994-07-13
EP0281833A3 (en)	1989-03-08	Gas-generating composition
GR3004959T3 (xx)	1993-04-28
ZA888726B (en)	1989-08-30	Tert-butyl phenyl compounds useful as anti-inflammatory agents
ZA88498B (en)	1989-10-25	Alkylmelatonins
IL71989A0 (en)	1984-10-31	L-arginine isoxicamate and pharmaceutical compositions containing it
GB8704839D0 (en)	1987-04-08	Compound compositions
IL65120A (en)	1985-11-29	Herbicidal thiocarbamate compositions containing 2,4-dinitrophenol as antidote thereto
UA19097A (uk)	1997-12-25	D-1-ФЕHІЛ-2-МЕТИЛАМІHОПРОПАHОЛА 1-5,6,7-ТРИОКСИФЛАВОH-7-0-beta-D-ГЛЮКУРОHИДАТ, ЩО МАЄ ОКИСЛЮВАЛЬHУ ДІЮ ТА РОЗШИРЮЄ СУДИHИ
DK1260222T3 (da)	2006-02-27	Farmaceutiske præparater indeholdende hidtil ukendte iso-butenyl-substituerede taxaner
IE851753L (en)	1986-01-13	Aminophenol compounds.
IE871800L (en)	1988-01-25	Bisphosphonate compositions.
EP0432983A3 (en)	1991-08-21	Novel compounds of the diterpene type

Legal Events

Date	Code	Title	Description
2003-02-12	KB	Patent renewed
2007-07-24	MM9K	Patent not in force due to non-payment of renewal fees