Nothing Special   »   [go: up one dir, main page]

IL88413A0 - Method for the selective cleavage of fusion proteins - Google Patents

Method for the selective cleavage of fusion proteins

Info

Publication number
IL88413A0
IL88413A0 IL88413A IL8841388A IL88413A0 IL 88413 A0 IL88413 A0 IL 88413A0 IL 88413 A IL88413 A IL 88413A IL 8841388 A IL8841388 A IL 8841388A IL 88413 A0 IL88413 A0 IL 88413A0
Authority
IL
Israel
Prior art keywords
fusion proteins
selective cleavage
cleavage
proteins
selective
Prior art date
Application number
IL88413A
Other versions
IL88413A (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL88413A0 publication Critical patent/IL88413A0/en
Publication of IL88413A publication Critical patent/IL88413A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Welding Or Cutting Using Electron Beams (AREA)
  • Exhaust Gas After Treatment (AREA)
  • Machines For Manufacturing Corrugated Board In Mechanical Paper-Making Processes (AREA)
  • Techniques For Improving Reliability Of Storages (AREA)
  • Fuses (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Polypeptides or proteins are prepared by enzymatic cleavage of the oligo- or polyglycine sequence of a fusion protein by means of endoprotease.
IL88413A 1987-11-20 1988-11-18 Method for the selective cleavage of fusion proteins IL88413A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873739347 DE3739347A1 (en) 1987-11-20 1987-11-20 METHOD FOR SELECTIVE CLEAVAGE OF FUSION PROTEINS

Publications (2)

Publication Number Publication Date
IL88413A0 true IL88413A0 (en) 1989-06-30
IL88413A IL88413A (en) 1993-07-08

Family

ID=6340882

Family Applications (1)

Application Number Title Priority Date Filing Date
IL88413A IL88413A (en) 1987-11-20 1988-11-18 Method for the selective cleavage of fusion proteins

Country Status (19)

Country Link
EP (1) EP0316748B1 (en)
JP (1) JPH01160496A (en)
KR (1) KR890008166A (en)
CN (1) CN1033184A (en)
AT (1) ATE78873T1 (en)
AU (1) AU618035B2 (en)
CA (1) CA1337283C (en)
DE (2) DE3739347A1 (en)
DK (1) DK645588A (en)
ES (1) ES2051816T3 (en)
FI (1) FI885328A (en)
GR (1) GR3006045T3 (en)
HU (1) HU204894B (en)
IE (1) IE62228B1 (en)
IL (1) IL88413A (en)
NO (1) NO173194C (en)
NZ (1) NZ226998A (en)
PT (1) PT89019B (en)
ZA (1) ZA888650B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780285A (en) * 1995-03-03 1998-07-14 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing dibasic residues
US5837516A (en) * 1995-03-03 1998-11-17 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing basic residues
ATE264871T1 (en) 1996-07-26 2004-05-15 Aventis Pharma Gmbh INSULIN DERIVATIVES WITH INCREASED ZINC BINDING
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
DE19825447A1 (en) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh New insulin analogues with increased zinc formation
BR0308710A (en) * 2002-03-26 2007-01-09 Biosynexus Inc antimicrobial polymer conjugates
CN101717449B (en) * 2008-10-09 2013-06-19 重庆富进生物医药有限公司 Recombinant TRAIL-Fc fusion protein as well as preparation and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3523701A1 (en) * 1985-07-03 1987-01-08 Bayer Ag PROCESS FOR PRODUCING PROTEINS AND POLYPEPTIDES

Also Published As

Publication number Publication date
GR3006045T3 (en) 1993-06-21
HUT50514A (en) 1990-02-28
CN1033184A (en) 1989-05-31
IE883462L (en) 1989-05-20
NZ226998A (en) 1991-06-25
ATE78873T1 (en) 1992-08-15
IE62228B1 (en) 1995-01-11
KR890008166A (en) 1989-07-10
FI885328A0 (en) 1988-11-17
EP0316748A3 (en) 1990-08-29
EP0316748A2 (en) 1989-05-24
NO885154L (en) 1989-05-22
DK645588D0 (en) 1988-11-18
DE3739347A1 (en) 1989-06-01
AU2569588A (en) 1989-06-29
NO885154D0 (en) 1988-11-18
EP0316748B1 (en) 1992-07-29
AU618035B2 (en) 1991-12-12
DE3873273D1 (en) 1992-09-03
ES2051816T3 (en) 1994-07-01
NO173194C (en) 1993-11-10
IL88413A (en) 1993-07-08
FI885328A (en) 1989-05-21
PT89019B (en) 1993-02-26
ZA888650B (en) 1989-07-26
JPH01160496A (en) 1989-06-23
HU204894B (en) 1992-02-28
CA1337283C (en) 1995-10-10
PT89019A (en) 1988-12-01
DK645588A (en) 1989-05-21
NO173194B (en) 1993-08-02

Similar Documents

Publication Publication Date Title
AU4434585A (en) Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique
AU573523B2 (en) Functional human urokinase proteins
DE3664483D1 (en) Method for the microbiological synthesis of human serum albumin
ES2083957T3 (en) METHOD FOR THE PRODUCTION OF PROTEINS USING FUSED PROTEINS OF THE CKS TYPE.
FI90667C (en) The method produces a novel human type I interferon protein
AU6661490A (en) Novel polypeptides, the DNA sequences allowing their expression, method of preparation, and utilization
IL88413A (en) Method for the selective cleavage of fusion proteins
ES2000859A6 (en) Method for producing fusion proteins.
HUT57268A (en) Process for producing strange protheine in streptomycetes
HUT53125A (en) Process for producing peptides with anticoagulant activity
DE3572843D1 (en) Site-specific proteolysis by renin
ES2005756A6 (en) Method for producing fusion proteins.
EP0254315A3 (en) Method for producing peptides
SE8800981A (en) A RECOMBINANT FUSION PROTEIN, ITS USE AND A RECOMBINANT VECTOR
AU2978989A (en) A method for the cleavage of fusion proteins
FI97239C (en) Process for producing fusion protein
ES2014613A6 (en) Method for the preparation of an expression module useful in the production of polypeptides

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
EXP Patent expired