IL86086A0 - Bifunctional proteins and pharmaceutical compositions containing them - Google Patents

Bifunctional proteins and pharmaceutical compositions containing them

Info

Publication number: IL86086A0
Authority: IL; Israel
Prior art keywords: pharmaceutical compositions; compositions containing; bifunctional proteins; bifunctional; proteins
Prior art date: 1987-04-16

Application number

IL86086A

Other versions

IL86086A (en

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-16

Filing date

1988-04-15

Publication date

1988-09-30

1988-04-15 Application filed by Hoechst Ag filed Critical Hoechst Ag

1988-09-30 Publication of IL86086A0 publication Critical patent/IL86086A0/en

1995-01-24 Publication of IL86086A publication Critical patent/IL86086A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

IL8608688A 1987-04-16 1988-04-15 Fusion protein with activities of interleukin-2 and gm-csf and pharmaceutical compositions containing said protein IL86086A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873712985 DE3712985A1 (en)	1987-04-16	1987-04-16	BIFUNCTIONAL PROTEINS

Publications (2)

Publication Number	Publication Date
IL86086A0 true IL86086A0 (en)	1988-09-30
IL86086A IL86086A (en)	1995-01-24

Family

ID=6325799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL8608688A IL86086A (en)	1987-04-16	1988-04-15	Fusion protein with activities of interleukin-2 and gm-csf and pharmaceutical compositions containing said protein

Country Status (20)

Country	Link
EP (1)	EP0288809B1 (en)
JP (1)	JP2667193B2 (en)
KR (1)	KR970000187B1 (en)
AR (1)	AR242991A1 (en)
AT (1)	ATE79135T1 (en)
AU (1)	AU613022B2 (en)
CA (1)	CA1322157C (en)
DE (2)	DE3712985A1 (en)
DK (1)	DK170741B1 (en)
ES (1)	ES2033981T3 (en)
FI (1)	FI98830C (en)
GR (1)	GR3006141T3 (en)
HU (1)	HU204303B (en)
IE (1)	IE61574B1 (en)
IL (1)	IL86086A (en)
NO (1)	NO176922C (en)
NZ (1)	NZ224247A (en)
PH (1)	PH25327A (en)
PT (1)	PT87237B (en)
ZA (1)	ZA882659B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5662896A (en) *	1988-03-21	1997-09-02	Chiron Viagene, Inc.	Compositions and methods for cancer immunotherapy
US5225538A (en) *	1989-02-23	1993-07-06	Genentech, Inc.	Lymphocyte homing receptor/immunoglobulin fusion proteins
US6406697B1 (en)	1989-02-23	2002-06-18	Genentech, Inc.	Hybrid immunoglobulins
US5116964A (en) *	1989-02-23	1992-05-26	Genentech, Inc.	Hybrid immunoglobulins
AU5355790A (en) *	1989-04-19	1990-11-16	Cetus Corporation	Multifunctional m-csf proteins and genes encoding therefor
US5108910A (en) *	1989-08-22	1992-04-28	Immunex Corporation	DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
US5073627A (en) *	1989-08-22	1991-12-17	Immunex Corporation	Fusion proteins comprising GM-CSF and IL-3
WO1991002754A1 (en) *	1989-08-22	1991-03-07	Immunex Corporation	Fusion proteins comprising gm-csf and il-3
US5376367A (en) *	1991-11-22	1994-12-27	Immunex Corporation	Fusion proteins comprising MGF and IL-3
US5723125A (en) *	1995-12-28	1998-03-03	Tanox Biosystems, Inc.	Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
DE69824039T2 (en)	1997-12-08	2005-08-18	Lexigen Pharmaceuticals Corp., Lexington	HETERODIMARY FUSION PROTEINS FOR THE USE OF TARGETED IMMUNOTHERAPY AND GENERAL IMMUNE REGION
SK782002A3 (en)	1999-07-21	2003-08-05	Lexigen Pharm Corp	FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
SK1842002A3 (en)	1999-08-09	2003-09-11	Lexigen Pharm Corp	A fusion protein, a multi-function protein complex, a multi-function fusion protein, a nucleic acid, a cell, their use, method for preparing a fusion protein and method of targeting cytokines
AU1551801A (en) *	1999-11-30	2001-06-12	Shionogi & Co., Ltd.	Chemokine slc-il2 fused protein and gene thereof
HUP0204475A2 (en)	2000-02-11	2003-04-28	Merck Patent Gmbh	Enhancing the circulating half-life of antibody-based fusion proteins
JP4234438B2 (en)	2001-03-07	2009-03-04	メルクパテントゲゼルシャフトミットベシュレンクテルハフトング	Expression technology of protein containing hybrid isotype antibody part
US6992174B2 (en)	2001-03-30	2006-01-31	Emd Lexigen Research Center Corp.	Reducing the immunogenicity of fusion proteins
ATE502053T1 (en)	2001-05-03	2011-04-15	Merck Patent Gmbh	RECOMBINANT TUMOR-SPECIFIC ANTIBODIES AND USE THEREOF
CN1635901B (en)	2001-10-10	2012-03-28	诺和诺德公司	Peptide remodeling and glycoconjugation methods
EP2354791A1 (en)	2001-12-04	2011-08-10	Merck Patent GmbH	Immunocytokines with modulated selectivity
ATE471946T1 (en)	2002-12-17	2010-07-15	Merck Patent Gmbh	HUMANIZED ANTIBODY (H14.18) OF THE MOUSE ANTIBODY 14.18 THAT BINDS GD2 AND ITS FUSION WITH IL-2
DK1648931T3 (en) *	2003-07-21	2011-03-07	Transgene Sa	Multifunctional cytokines
DE602004031341D1 (en)	2003-07-21	2011-03-24	Transgene Sa	MULTIFUNCTIONAL CYTOKINE
WO2010001414A1 (en) *	2008-07-03	2010-01-07	Lupin Limited	Expression of heterologous proteins in bacterial system using a gm-csf fusion tag

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1985000817A1 (en) *	1983-08-10	1985-02-28	Amgen	Microbial expression of interleukin ii
GB8327880D0 (en) *	1983-10-18	1983-11-16	Ajinomoto Kk	Saccharomyces cerevisiae
EP0158198A1 (en) *	1984-03-29	1985-10-16	Takeda Chemical Industries, Ltd.	DNA and use thereof
WO1985004673A1 (en) *	1984-04-10	1985-10-24	Takeda Chemical Industries, Ltd.	Novel dna and its use
DE3419995A1 (en) *	1984-05-29	1985-12-05	Hoechst Ag, 6230 Frankfurt	GENE TECHNOLOGICAL METHOD FOR PRODUCING HUMAN INTERLEUKIN-2 AND MEANS FOR CARRYING OUT THIS METHOD
AU588819B2 (en) *	1984-10-29	1989-09-28	Immunex Corporation	Cloning of human granulocyte-macrophage colony stimulating factor gene
JPS61128889A (en) *	1984-11-27	1986-06-16	Green Cross Corp:The	Recombinant DNA and transformants using the DNA
JPH0646957B2 (en) *	1985-03-11	1994-06-22	武田薬品工業株式会社	Method for producing interleukin-2
EP0238655A4 (en) *	1985-10-03	1989-09-11	Biogen Nv	Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells.
DE3541856A1 (en) *	1985-11-27	1987-06-04	Hoechst Ag	EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS
DE3545568A1 (en) *	1985-12-21	1987-07-16	Hoechst Ag	GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE

1987
- 1987-04-16 DE DE19873712985 patent/DE3712985A1/en not_active Withdrawn
1988
- 1988-04-09 AT AT88105693T patent/ATE79135T1/en not_active IP Right Cessation
- 1988-04-09 DE DE8888105693T patent/DE3873397D1/en not_active Expired - Fee Related
- 1988-04-09 ES ES198888105693T patent/ES2033981T3/en not_active Expired - Lifetime
- 1988-04-09 EP EP88105693A patent/EP0288809B1/en not_active Expired - Lifetime
- 1988-04-14 NZ NZ224247A patent/NZ224247A/en unknown
- 1988-04-14 PT PT87237A patent/PT87237B/en active IP Right Grant
- 1988-04-14 FI FI881743A patent/FI98830C/en not_active IP Right Cessation
- 1988-04-15 IL IL8608688A patent/IL86086A/en not_active IP Right Cessation
- 1988-04-15 HU HU881966A patent/HU204303B/en not_active IP Right Cessation
- 1988-04-15 NO NO881658A patent/NO176922C/en not_active IP Right Cessation
- 1988-04-15 CA CA000564322A patent/CA1322157C/en not_active Expired - Fee Related
- 1988-04-15 AU AU14661/88A patent/AU613022B2/en not_active Ceased
- 1988-04-15 AR AR88310585A patent/AR242991A1/en active
- 1988-04-15 ZA ZA882659A patent/ZA882659B/en unknown
- 1988-04-15 IE IE114688A patent/IE61574B1/en not_active IP Right Cessation
- 1988-04-15 JP JP63093321A patent/JP2667193B2/en not_active Expired - Fee Related
- 1988-04-15 DK DK209188A patent/DK170741B1/en not_active IP Right Cessation
- 1988-04-16 KR KR1019880004345A patent/KR970000187B1/en not_active IP Right Cessation
1989
- 1989-04-14 PH PH36799A patent/PH25327A/en unknown
1992
- 1992-11-04 GR GR920402185T patent/GR3006141T3/el unknown

Also Published As

Publication number	Publication date
FI881743A (en)	1988-10-17
EP0288809A1 (en)	1988-11-02
DK209188A (en)	1988-10-17
DK209188D0 (en)	1988-04-15
ATE79135T1 (en)	1992-08-15
EP0288809B1 (en)	1992-08-05
NO176922B (en)	1995-03-13
IE61574B1 (en)	1994-11-16
ZA882659B (en)	1988-10-14
ES2033981T3 (en)	1993-04-01
AR242991A1 (en)	1993-06-30
PT87237A (en)	1988-05-01
AU1466188A (en)	1988-10-20
FI98830C (en)	1997-08-25
HUT47319A (en)	1989-02-28
CA1322157C (en)	1993-09-14
NO881658L (en)	1988-10-17
FI98830B (en)	1997-05-15
JPS63301898A (en)	1988-12-08
KR970000187B1 (en)	1997-01-06
GR3006141T3 (en)	1993-06-21
NO881658D0 (en)	1988-04-15
NZ224247A (en)	1990-04-26
PT87237B (en)	1992-07-31
HU204303B (en)	1991-12-30
KR880012760A (en)	1988-11-29
DE3712985A1 (en)	1988-11-03
IE881146L (en)	1988-10-16
FI881743A0 (en)	1988-04-14
JP2667193B2 (en)	1997-10-27
DE3873397D1 (en)	1992-09-10
DK170741B1 (en)	1996-01-08
NO176922C (en)	1995-06-21
PH25327A (en)	1991-04-30
IL86086A (en)	1995-01-24
AU613022B2 (en)	1991-07-25

Publication	Publication Date	Title
IL82221A0 (en)	1987-10-30	Phenyl-piperazines and pharmaceutical compositions containing them
IL86086A0 (en)	1988-09-30	Bifunctional proteins and pharmaceutical compositions containing them
IL95351A0 (en)	1991-06-30	17beta-acyl-4-aza-5alpha-androst-1-en-3-ones and pharmaceutical compositions containing them
NZ220345A (en)	1990-10-26	Imidazoquinolinylether derivatives and pharmaceutical compositions containing them
NZ222980A (en)	1989-11-28	3-aryloxy-3-substituted propanamines and pharmaceutical compositions
IL90067A0 (en)	1989-12-15	1alpha-hydroxyvitamin-d compounds and pharmaceutical compositions containing them
NZ223096A (en)	1990-09-26	Peptidylaminodiols and pharmaceutical compositions
IL88156A (en)	1997-02-18	Azacyclic compounds their preparation and pharmaceutical compositions containing them
IL87079A0 (en)	1988-12-30	Tetrahydrocarbazole 1-alkanoic acids and pharmaceutical compositions containing them
NZ213563A (en)	1991-08-27	Anticoagulant proteins and pharmaceutical compositions
IL85896A0 (en)	1988-09-30	Substituted di-tert.-butylphenols and pharmaceutical compositions containing them
GR871659B (en)	1988-03-03	Substituted a-aminoacids their preparation and pharmaceutical compositions containing them
NZ226002A (en)	1990-06-26	Peptidylheterocyclic compounds and pharmaceutical compositions
GB2207922B (en)	1991-02-20	Tripeptides and pharmaceutical compositions containing them
IL88433A0 (en)	1989-06-30	Diarylstyrylquinoline diacids and pharmaceutical compositions containing them
IL79376A0 (en)	1986-10-31	Substituted di-t-butylphenols and pharmaceutical compositions containing them
IL82205A0 (en)	1987-10-30	Substituted alkanesulfonamidophenyl derivatives and pharmaceutical compositions containing them
IL78939A0 (en)	1986-09-30	N-substituted arylalkyl-and arylalkylene-aminoheterocyclics and pharmaceutical compositions containing them
IL87644A0 (en)	1989-02-28	Oxadiazolyl-azabicycloheptanes,their preparation and pharmaceutical compositions containing them
NZ226450A (en)	1990-05-28	Crystalline-1-carbacephalosporin and pharmaceutical compositions
NZ225613A (en)	1990-09-26	Benzazepin-2-one derivatives and pharmaceutical compositions
IL79003A0 (en)	1986-09-30	Tetrahydroimidazoquinazolinones and pharmaceutical compositions containing them
IL86926A0 (en)	1988-11-30	1h-pyrazole-1-alkanamides,their preparation and pharmaceutical compositions containing them
NZ219748A (en)	1989-05-29	Indenopyrimidines and pharmaceutical compositions
IL92650A0 (en)	1990-08-31	Polyhydroxybenzyloxypropanolamides and pharmaceutical compositions containing them

Legal Events

Date	Code	Title
1998-10-30	KB	Patent renewed
2002-05-23	KB	Patent renewed
2006-12-27	MM9K	Patent not in force due to non-payment of renewal fees