IL202318A0 - 5-heteroaryl substituted indazoles as kinase inhibitors - Google Patents
5-heteroaryl substituted indazoles as kinase inhibitorsInfo
- Publication number
- IL202318A0 IL202318A0 IL202318A IL20231809A IL202318A0 IL 202318 A0 IL202318 A0 IL 202318A0 IL 202318 A IL202318 A IL 202318A IL 20231809 A IL20231809 A IL 20231809A IL 202318 A0 IL202318 A0 IL 202318A0
- Authority
- IL
- Israel
- Prior art keywords
- kinase inhibitors
- heteroaryl substituted
- substituted indazoles
- indazoles
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93396007P | 2007-06-08 | 2007-06-08 | |
PCT/US2008/065727 WO2008154241A1 (en) | 2007-06-08 | 2008-06-04 | 5-heteroaryl substituted indazoles as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
IL202318A0 true IL202318A0 (en) | 2010-06-30 |
Family
ID=39951673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL202318A IL202318A0 (en) | 2007-06-08 | 2009-11-24 | 5-heteroaryl substituted indazoles as kinase inhibitors |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP2167491A1 (en) |
JP (2) | JP5451602B2 (en) |
KR (1) | KR20100032886A (en) |
CN (1) | CN101790526A (en) |
AU (1) | AU2008262038A1 (en) |
BR (1) | BRPI0811065A2 (en) |
CA (1) | CA2689117A1 (en) |
IL (1) | IL202318A0 (en) |
MX (1) | MX2009013213A (en) |
RU (1) | RU2487873C2 (en) |
SG (1) | SG182187A1 (en) |
WO (1) | WO2008154241A1 (en) |
ZA (1) | ZA200908624B (en) |
Families Citing this family (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
AU2007218059A1 (en) | 2006-02-16 | 2007-08-30 | Schering Corporation | Pyrrolidine derivatives as ERK inhibitors |
US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
EP2157859A4 (en) * | 2007-06-19 | 2011-01-12 | Takeda Pharmaceutical | Indazole compounds for activating glucokinase |
WO2009011871A2 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
US7897619B2 (en) | 2007-07-17 | 2011-03-01 | Amgen Inc. | Heterocyclic modulators of PKB |
BRPI0816095A2 (en) * | 2007-08-30 | 2015-03-03 | Takeda Pharmaceutical | COMPOUND OR SALT OF THE SAME, PRODUCT, PHARMACEUTICAL AGENT, METHODS FOR ANTAGONIZING AN ANDROGEN RECEIVER AND FOR PREVENTING / TREATING CANCER, AND, USE OF THE COMPOUND OR PRODUCT OF THE SAME. |
ES2556353T3 (en) | 2008-02-21 | 2016-01-15 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
CL2009001158A1 (en) | 2008-05-15 | 2009-10-23 | Nerviano Medical Sciences Srl | Compounds derived from carboxylic acids, such as 5,6-dihiro-4h-pyrrolo [3,4-c] pyrazole, furo [3,2-c] pyrazole, thieno [2,3-c] pyrazole, 4,5 , 6,7-tetrahydropyrazole [4,3-c] pyridine and indazole; pharmaceutical composition; and its use in the treatment of cell proliferative disorders associated with altered protein kinase activity, such as cancer. |
ES2548141T3 (en) * | 2008-11-20 | 2015-10-14 | Glaxosmithkline Llc | Chemical compounds |
EP2987487B1 (en) | 2009-08-10 | 2020-10-07 | Samumed, LLC | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
JP5822844B2 (en) | 2009-12-21 | 2015-11-24 | サミュメッド リミテッド ライアビリティ カンパニー | 1H-pyrazolo [3,4-b] pyridine and therapeutic use thereof |
UY33213A (en) * | 2010-02-18 | 2011-09-30 | Almirall Sa | PIRAZOL DERIVATIVES AS JAK INHIBITORS |
KR101233082B1 (en) | 2010-02-25 | 2013-02-14 | 주식회사 이큐스앤자루 | A composition containing of novel imidazole pyrazine compound having Influenza virus activity for treating antivirus |
EP2542549B1 (en) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
RU2012136643A (en) * | 2010-04-28 | 2014-06-10 | Дайити Санкио Компани, Лимитед | [5,6] - HETEROCYCLIC COMPOUND |
WO2011140333A1 (en) | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
WO2012084704A1 (en) | 2010-12-20 | 2012-06-28 | Merck Serono S.A. | Indazolyl triazole derivatives as irak inhibitors |
JP5918264B2 (en) | 2010-12-22 | 2016-05-18 | アッヴィ・インコーポレイテッド | Hepatitis C inhibitor and use thereof |
US9090592B2 (en) * | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
CN102675286B (en) * | 2011-03-07 | 2015-08-19 | 中国科学院上海药物研究所 | One class indazole compounds and preparation method thereof, purposes and pharmaceutical composition |
PT2694510E (en) * | 2011-04-07 | 2016-02-08 | Bayer Pharma AG | Imidazopyridazines as akt kinase inhibitors |
MX355852B (en) * | 2011-08-12 | 2018-05-02 | Hoffmann La Roche | PYRAZOLO[3,4-c]PYRIDINE COMPOUNDS AND METHODS OF USE. |
CN103929963A (en) | 2011-09-14 | 2014-07-16 | 萨穆梅德有限公司 | Indazole-3-carboxamides and their use as WNT/beta-CATENIN signaling pathway inhibitors |
JP6169104B2 (en) | 2011-12-27 | 2017-07-26 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | Heteroarylpiperidine derivatives and heteroarylpiperazine derivatives as fungicides |
MX351287B (en) * | 2012-02-21 | 2017-10-09 | Acraf | 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors. |
PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
NZ741907A (en) | 2012-05-04 | 2020-02-28 | Samumed Llc | 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
TW201406758A (en) * | 2012-06-28 | 2014-02-16 | Daiichi Sankyo Co Ltd | Tricyclic compounds |
CN105120862A (en) | 2013-01-08 | 2015-12-02 | 萨穆梅德有限公司 | 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof |
WO2014134774A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
WO2014134776A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
WO2014134772A1 (en) * | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
US9440952B2 (en) | 2013-03-04 | 2016-09-13 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
JO3383B1 (en) * | 2013-03-14 | 2019-03-13 | Lilly Co Eli | CDC7 Inhibitors |
CA2915622C (en) * | 2013-06-21 | 2020-08-18 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
BR112016018555B1 (en) | 2014-02-13 | 2024-01-23 | Incyte Holdings Corporation | CYCLOPROPYLAMINES AS LSD1 INHIBITORS, THEIR USE, PHARMACEUTICAL COMPOSITION COMPRISING THEM AND METHOD OF LSD1 INHIBITION |
EP3105219B9 (en) | 2014-02-13 | 2018-10-03 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
WO2015123465A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
BR112016021626A2 (en) | 2014-03-20 | 2018-05-15 | Samumed, Llc | 5-substituted indazol-3-carboxamides and their preparation and use |
WO2015143652A1 (en) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
JP6675334B2 (en) * | 2014-06-25 | 2020-04-01 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Imidazo [1,2-a] pyrazin-1-ylbenzamide compounds for treating spinal muscular atrophy |
WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
WO2016007727A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
US9695180B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors |
WO2016007731A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines and imidazopyrazines as lsd1 inhibitors |
JP6543342B2 (en) | 2014-08-14 | 2019-07-10 | アルハマドシャー,マモウン,エム. | Conjugation of a pharmaceutically active agent with a transthyretin ligand via a regulatable linker to extend serum half life |
WO2016040182A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof |
WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
WO2016040188A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
WO2016040190A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
SG11201705821XA (en) * | 2015-03-02 | 2017-08-30 | Rigel Pharmaceuticals Inc | TGF-ß INHIBITORS |
PE20180455A1 (en) | 2015-04-03 | 2018-03-05 | Incyte Corp | HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS |
US10226453B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
WO2017023987A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
US10604512B2 (en) | 2015-08-03 | 2020-03-31 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof |
US10206909B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
WO2017023996A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
WO2017023984A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
WO2017024003A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
WO2017023988A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
WO2017024025A1 (en) | 2015-08-03 | 2017-02-09 | Sunil Kumar Kc | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
US10383861B2 (en) | 2015-08-03 | 2019-08-20 | Sammumed, LLC | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
WO2017024010A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
US10329309B2 (en) | 2015-08-03 | 2019-06-25 | Samumed, Llc | 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
WO2017023989A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
WO2017023980A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
WO2017024026A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
US10195185B2 (en) | 2015-08-03 | 2019-02-05 | Samumed, Llc | 3-(1H-imidazo[4,5-C]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
EA035534B1 (en) | 2015-08-12 | 2020-06-30 | Инсайт Корпорейшн | Salts of an lsd1 inhibitor |
EP3370721A4 (en) | 2015-11-06 | 2019-05-22 | Samumed, LLC | Treatment of osteoarthritis |
US20170273307A1 (en) * | 2016-03-28 | 2017-09-28 | Trent University | Silane-based antimicrobial coatings and methods of making and using the same |
JP6999574B2 (en) | 2016-04-22 | 2022-01-18 | インサイト・コーポレイション | Preparation of LSD1 inhibitor |
PT3464285T (en) | 2016-06-01 | 2022-12-20 | Biosplice Therapeutics Inc | Process for preparing n-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide |
ES2890924T3 (en) * | 2016-09-21 | 2022-01-25 | Vectus Biosystems Ltd | Imidazole derivatives for the treatment of hypertension and/or fibrosis |
DK3515894T3 (en) | 2016-09-23 | 2021-07-05 | Novartis Ag | INDAZOLE COMPOUNDS FOR USE OF T tendon and / or ligament injuries |
JOP20190053A1 (en) | 2016-09-23 | 2019-03-21 | Novartis Ag | Aza-indazole compounds for use in tendon and/or ligament injuries |
CN110709082A (en) | 2016-10-21 | 2020-01-17 | 萨穆梅德有限公司 | Methods of use of indazole-3-carboxamides and their use as inhibitors of the Wnt/beta-catenin signaling pathway |
MA46696A (en) | 2016-11-07 | 2019-09-11 | Samumed Llc | READY-TO-USE SINGLE-DOSE INJECTABLE FORMULATIONS |
PL3689868T3 (en) | 2016-12-01 | 2024-03-11 | Arvinas Operations, Inc. | Tetrahydronaphthalene and tetrahydroisoquinoline derivatives as estrogen receptor degraders |
AU2018222739C1 (en) | 2017-02-17 | 2024-10-03 | Eidos Therapeutics, Inc. | Processes for preparing AG-10, its intermediates, and salts thereof |
WO2019001572A1 (en) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof |
ES2930804T3 (en) * | 2017-06-30 | 2022-12-22 | Beijing Tide Pharmaceutical Co Ltd | RHO-associated protein kinase inhibitor, pharmaceutical composition that comprises it, as well as method of preparation and use thereof |
CA3088577A1 (en) | 2018-02-15 | 2019-08-22 | Vertex Pharmaceuticals Incorporated | Macrocycles as modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions thereof, their use in the treatment of cycstic fibrosis, and process for making them |
MA52137A (en) | 2018-03-23 | 2021-01-27 | Eidos Therapeutics Inc | METHODS OF TREATMENT OF TTR AMYLOSIS USING AG10 |
JP7187575B2 (en) * | 2018-04-18 | 2022-12-12 | メッドシャイン ディスカバリー インコーポレイテッド | Benzopyrazole compounds as RHO kinase inhibitors |
MX2021001761A (en) | 2018-08-17 | 2021-04-19 | Eidos Therapeutics Inc | Formulations of ag10. |
WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
CN111138426B (en) * | 2018-11-02 | 2023-03-10 | 安徽中科拓苒药物科学研究有限公司 | Indazole kinase inhibitor and application thereof |
WO2020163812A1 (en) | 2019-02-08 | 2020-08-13 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
CN110218694A (en) * | 2019-05-30 | 2019-09-10 | 华中农业大学 | A kind of kiwifruit fruit amyloplaste extracting method |
TW202120517A (en) | 2019-08-14 | 2021-06-01 | 美商維泰克斯製藥公司 | Process of making cftr modulators |
EP4013760A1 (en) | 2019-08-14 | 2022-06-22 | Vertex Pharmaceuticals Incorporated | Crystalline forms of cftr modulators |
TW202115092A (en) | 2019-08-14 | 2021-04-16 | 美商維泰克斯製藥公司 | Modulators of cystic fibrosis transmembrane conductance regulator |
CN111171023B (en) * | 2020-01-10 | 2021-12-21 | 中国药科大学 | Compound with Pim1 inhibitory activity and preparation method and medical application thereof |
CN113350347B (en) * | 2020-03-05 | 2023-07-04 | 安徽中科拓苒药物科学研究有限公司 | Use of indazoles |
JP2023540674A (en) * | 2020-07-15 | 2023-09-26 | アイエフエム デュー インコーポレイテッド | Compounds and compositions for treating conditions associated with STING activity |
EP4225750A1 (en) * | 2020-10-07 | 2023-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
CN112266378B (en) * | 2020-11-09 | 2021-10-12 | 延边大学 | Imidazole derivative containing indazole structure and preparation method and application thereof |
CN113336759B (en) * | 2020-12-25 | 2022-12-06 | 中国药科大学 | Bromodomain protein 4 small molecule inhibitor, preparation method and application thereof |
CN117529475A (en) * | 2021-01-08 | 2024-02-06 | 艾福姆德尤股份有限公司 | Heterobicyclic compounds containing urea or analogs for the treatment of diseases associated with STING activity and compounds thereof |
KR20230056824A (en) * | 2021-10-20 | 2023-04-28 | 전북대학교산학협력단 | PAK4 inhibitors and use thereof |
WO2023186773A1 (en) | 2022-03-30 | 2023-10-05 | Nerviano Medical Sciences S.R.L. | Substituted 3-amino indazole derivatives as kinase inhibitors |
CN114651898B (en) * | 2022-03-31 | 2024-04-05 | 天津溢佳同惠科技集团有限公司 | Triazole feed additive for improving immunity as well as preparation method and application thereof |
WO2023218201A1 (en) * | 2022-05-11 | 2023-11-16 | Cancer Research Technology Limited | Ikk inhibitors |
KR102607237B1 (en) * | 2023-06-07 | 2023-11-30 | 주식회사 젠센 | New triazole substituted indazole derivatives and use thereof |
CN116891460A (en) * | 2023-07-12 | 2023-10-17 | 浙江大学 | Indazole derivative or pharmaceutically acceptable salt thereof and application thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU54202A (en) * | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Indazole compounds,pharmaceutical compositions,and methods for mediating or inhibiting cell proliferation |
US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
US20040102455A1 (en) * | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
ATE339419T1 (en) * | 2002-08-02 | 2006-10-15 | Vertex Pharma | PYRAZOLE-CONTAINING COMPOSITIONS AND THEIR USE AS GSK-3 INHIBITORS |
GB2391557A (en) * | 2002-08-06 | 2004-02-11 | Richard Stone | Forming fabric for papermaking |
FR2845382A1 (en) * | 2002-10-02 | 2004-04-09 | Sanofi Synthelabo | INDAZOLECARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS |
US20040087642A1 (en) * | 2002-10-24 | 2004-05-06 | Zeldis Jerome B. | Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain |
RU2339624C2 (en) * | 2002-12-12 | 2008-11-27 | Авентис Фарма С.А. | Derivatives of aminoindazols and their application as kinases inhibitors |
US7008953B2 (en) * | 2003-07-30 | 2006-03-07 | Agouron Pharmaceuticals, Inc. | 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
US20050090529A1 (en) * | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
US20080293716A1 (en) * | 2004-01-30 | 2008-11-27 | Smithkline Beecham Corporation | Chemical Compounds |
FR2867778B1 (en) * | 2004-03-16 | 2006-06-09 | Sanofi Synthelabo | USE OF INDAZOLECARBOXAMIDE DERIVATIVES FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT AND PREVENTION OF MALARIA |
CA2567977A1 (en) * | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
DE102004028862A1 (en) * | 2004-06-15 | 2005-12-29 | Merck Patent Gmbh | 3-aminoindazoles |
US7429604B2 (en) * | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
EP1758873A1 (en) * | 2004-06-22 | 2007-03-07 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
ZA200704959B (en) * | 2004-12-27 | 2009-04-29 | Alcon Inc | Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases |
EP1891051A2 (en) * | 2005-04-29 | 2008-02-27 | Celgene Corporation | Solid forms of 1-( 5-(ih-i , 2 , 4 -triazol- 5 -yl)(1h-indazol-3-yl))-3-(2-piperidylethoxy)benzene |
TW200803863A (en) * | 2005-11-10 | 2008-01-16 | Schering Corp | Method for inhibiting protein kinases |
JP5255559B2 (en) * | 2006-03-31 | 2013-08-07 | アボット・ラボラトリーズ | Indazole compound |
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