IL165790A0 - Cationically substituted diphenyl azetidinones method for their production medicaments containing said compounds and use thereof - Google Patents
Cationically substituted diphenyl azetidinones method for their production medicaments containing said compounds and use thereofInfo
- Publication number
- IL165790A0 IL165790A0 IL16579004A IL16579004A IL165790A0 IL 165790 A0 IL165790 A0 IL 165790A0 IL 16579004 A IL16579004 A IL 16579004A IL 16579004 A IL16579004 A IL 16579004A IL 165790 A0 IL165790 A0 IL 165790A0
- Authority
- IL
- Israel
- Prior art keywords
- compounds
- production
- medicaments containing
- substituted diphenyl
- cationically substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention relates to compounds of formula (I), in which R1, R2, R3, R4, R5 and R6 are defined as cited, in addition to their physiologically compatible salts. The compounds are suitable for use e.g. as hypolipidaemics.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10227507A DE10227507A1 (en) | 2002-06-19 | 2002-06-19 | Cationically substituted diphenylazetidinones, processes for their preparation, medicaments containing these compounds and their use |
PCT/EP2003/005814 WO2004000803A1 (en) | 2002-06-19 | 2003-06-04 | Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
IL165790A0 true IL165790A0 (en) | 2006-01-15 |
IL165790A IL165790A (en) | 2010-04-15 |
Family
ID=29719282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL165790A IL165790A (en) | 2002-06-19 | 2004-12-15 | Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1517890B1 (en) |
JP (1) | JP2005533071A (en) |
KR (1) | KR20050010061A (en) |
CN (1) | CN1662494A (en) |
AT (1) | ATE401304T1 (en) |
AU (1) | AU2003238209B2 (en) |
BR (1) | BR0311984A (en) |
CA (1) | CA2490108A1 (en) |
DE (2) | DE10227507A1 (en) |
DK (1) | DK1517890T3 (en) |
ES (1) | ES2310662T3 (en) |
HR (1) | HRP20041202A2 (en) |
IL (1) | IL165790A (en) |
MA (1) | MA27251A1 (en) |
MX (1) | MXPA04012308A (en) |
NO (1) | NO20050088L (en) |
PA (1) | PA8575601A1 (en) |
PL (1) | PL372660A1 (en) |
PT (1) | PT1517890E (en) |
RS (1) | RS108604A (en) |
RU (1) | RU2315753C2 (en) |
SV (1) | SV2004001555A (en) |
TW (1) | TW200406380A (en) |
UY (1) | UY27852A1 (en) |
WO (1) | WO2004000803A1 (en) |
ZA (1) | ZA200409379B (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
EP1699759B1 (en) | 2003-12-23 | 2010-10-20 | AstraZeneca AB | Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity |
NZ555320A (en) | 2004-12-03 | 2010-11-26 | Schering Corp | Substituted piperazines as CB1 antagonists |
MX2007012253A (en) | 2005-04-04 | 2007-12-07 | Univ Pontificia Catolica Chile | The use of ezetimibe in the prevention and treatment of cholesterol gallstones. |
CN101243072A (en) | 2005-06-20 | 2008-08-13 | 先灵公司 | Piperidine derivatives useful as histamine H3 antagonists |
SA06270191B1 (en) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions |
TW200811098A (en) | 2006-04-27 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
AU2007283113A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
DE102007002260A1 (en) | 2007-01-16 | 2008-07-31 | Sanofi-Aventis | Use of substituted pyranonic acid derivatives for the preparation of medicaments for the treatment of the metabolic syndrome |
EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
DE102007054497B3 (en) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | New crystalline hydrate form of dodecanedioic acid 4-((2S,3R)-3-((S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl)-benzylamide ((2S,3R,4R,5R)-pentahydroxy-hexyl)-amide useful e.g. to treat hyperlipidemia |
UY31968A (en) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | NEW HETEROCYCLIC DERIVATIVES, THEIR PROCESSES FOR THEIR PREPARATION, AND THEIR THERAPEUTIC USES |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
WO2010100255A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
CN101993403B (en) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | Azetidinone compound and medical applications thereof |
ES2443016T3 (en) | 2009-08-26 | 2014-02-17 | Sanofi | New crystalline hydrates of heteroaromatic fluoroglycosides, pharmaceutical products comprising these compounds, and their use |
WO2011157827A1 (en) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
EP2683705B1 (en) | 2011-03-08 | 2015-04-22 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120052A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
EP2683699B1 (en) | 2011-03-08 | 2015-06-24 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2683700B1 (en) | 2011-03-08 | 2015-02-18 | Sanofi | Tetra-substituted oxathiazine derivatives, method for their preparation, their usage as medicament and medicament containing same and its use |
WO2012120053A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10042447A1 (en) * | 2000-08-29 | 2002-03-28 | Aventis Pharma Gmbh | Vertebrate intestinal protein that absorbs cholesterol and use of this protein to identify inhibitors of intestinal cholesterol transport |
AU2002231688A1 (en) * | 2000-12-21 | 2002-07-01 | Sanofi-Aventis Deutschland Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
IL156552A0 (en) * | 2000-12-21 | 2004-01-04 | Aventis Pharma Gmbh | Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use |
MXPA03005155A (en) * | 2000-12-21 | 2003-09-10 | Aventis Pharma Gmbh | Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism. |
-
2002
- 2002-06-19 DE DE10227507A patent/DE10227507A1/en not_active Withdrawn
-
2003
- 2003-06-04 RU RU2005101088/04A patent/RU2315753C2/en not_active IP Right Cessation
- 2003-06-04 ES ES03735534T patent/ES2310662T3/en not_active Expired - Lifetime
- 2003-06-04 DE DE50310161T patent/DE50310161D1/en not_active Expired - Lifetime
- 2003-06-04 CA CA002490108A patent/CA2490108A1/en not_active Abandoned
- 2003-06-04 EP EP03735534A patent/EP1517890B1/en not_active Expired - Lifetime
- 2003-06-04 JP JP2004514659A patent/JP2005533071A/en not_active Abandoned
- 2003-06-04 AT AT03735534T patent/ATE401304T1/en not_active IP Right Cessation
- 2003-06-04 PL PL03372660A patent/PL372660A1/en not_active Application Discontinuation
- 2003-06-04 DK DK03735534T patent/DK1517890T3/en active
- 2003-06-04 MX MXPA04012308A patent/MXPA04012308A/en active IP Right Grant
- 2003-06-04 AU AU2003238209A patent/AU2003238209B2/en not_active Ceased
- 2003-06-04 WO PCT/EP2003/005814 patent/WO2004000803A1/en active IP Right Grant
- 2003-06-04 KR KR10-2004-7020518A patent/KR20050010061A/en not_active Application Discontinuation
- 2003-06-04 PT PT03735534T patent/PT1517890E/en unknown
- 2003-06-04 BR BR0311984-0A patent/BR0311984A/en not_active IP Right Cessation
- 2003-06-04 RS YUP-1086/04A patent/RS108604A/en unknown
- 2003-06-04 CN CN038140934A patent/CN1662494A/en active Pending
- 2003-06-13 PA PA20038575601A patent/PA8575601A1/en unknown
- 2003-06-16 SV SV2003001555A patent/SV2004001555A/en unknown
- 2003-06-16 UY UY27852A patent/UY27852A1/en unknown
- 2003-06-17 TW TW092116320A patent/TW200406380A/en unknown
-
2004
- 2004-11-22 ZA ZA200409379A patent/ZA200409379B/en unknown
- 2004-12-08 MA MA27989A patent/MA27251A1/en unknown
- 2004-12-15 IL IL165790A patent/IL165790A/en not_active IP Right Cessation
- 2004-12-17 HR HR20041202A patent/HRP20041202A2/en not_active Application Discontinuation
-
2005
- 2005-01-06 NO NO20050088A patent/NO20050088L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HRP20041202A2 (en) | 2005-06-30 |
CN1662494A (en) | 2005-08-31 |
CA2490108A1 (en) | 2003-12-31 |
ATE401304T1 (en) | 2008-08-15 |
RS108604A (en) | 2007-02-05 |
UY27852A1 (en) | 2003-12-31 |
ES2310662T3 (en) | 2009-01-16 |
PT1517890E (en) | 2008-10-14 |
PA8575601A1 (en) | 2004-02-07 |
KR20050010061A (en) | 2005-01-26 |
EP1517890A1 (en) | 2005-03-30 |
SV2004001555A (en) | 2004-03-19 |
AU2003238209B2 (en) | 2009-01-22 |
NO20050088L (en) | 2005-01-06 |
IL165790A (en) | 2010-04-15 |
PL372660A1 (en) | 2005-07-25 |
WO2004000803A1 (en) | 2003-12-31 |
ZA200409379B (en) | 2006-05-31 |
TW200406380A (en) | 2004-05-01 |
MA27251A1 (en) | 2005-03-01 |
JP2005533071A (en) | 2005-11-04 |
AU2003238209A1 (en) | 2004-01-06 |
RU2005101088A (en) | 2005-06-27 |
EP1517890B1 (en) | 2008-07-16 |
DK1517890T3 (en) | 2008-11-10 |
MXPA04012308A (en) | 2005-02-25 |
RU2315753C2 (en) | 2008-01-27 |
DE10227507A1 (en) | 2004-01-08 |
DE50310161D1 (en) | 2008-08-28 |
BR0311984A (en) | 2005-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
MM9K | Patent not in force due to non-payment of renewal fees |