Nothing Special   »   [go: up one dir, main page]

IL153303A0 - Analgesic and anti-inflammatory compositions conaining cox-2 inhibitors - Google Patents

Analgesic and anti-inflammatory compositions conaining cox-2 inhibitors

Info

Publication number
IL153303A0
IL153303A0 IL15330301A IL15330301A IL153303A0 IL 153303 A0 IL153303 A0 IL 153303A0 IL 15330301 A IL15330301 A IL 15330301A IL 15330301 A IL15330301 A IL 15330301A IL 153303 A0 IL153303 A0 IL 153303A0
Authority
IL
Israel
Prior art keywords
analgesic
conaining
cox
inhibitors
inflammatory compositions
Prior art date
Application number
IL15330301A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of IL153303A0 publication Critical patent/IL153303A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL15330301A 2000-06-13 2001-06-13 Analgesic and anti-inflammatory compositions conaining cox-2 inhibitors IL153303A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21130700P 2000-06-13 2000-06-13
PCT/US2001/018990 WO2001095898A1 (en) 2000-06-13 2001-06-13 Analgesic and anti-inflammatory compositions containing cox-2 inhibitors

Publications (1)

Publication Number Publication Date
IL153303A0 true IL153303A0 (en) 2003-07-06

Family

ID=22786362

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15330301A IL153303A0 (en) 2000-06-13 2001-06-13 Analgesic and anti-inflammatory compositions conaining cox-2 inhibitors
IL153303A IL153303A (en) 2000-06-13 2002-12-05 Preparations of selcoxib and ibuprofen and their use in relieving pain or swelling

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL153303A IL153303A (en) 2000-06-13 2002-12-05 Preparations of selcoxib and ibuprofen and their use in relieving pain or swelling

Country Status (23)

Country Link
US (2) US6924303B2 (xx)
EP (1) EP1296665B1 (xx)
JP (1) JP5579958B2 (xx)
KR (1) KR20030019422A (xx)
CN (1) CN100588395C (xx)
AT (1) ATE511844T1 (xx)
AU (2) AU2001268377B2 (xx)
BR (1) BR0111767A (xx)
CA (1) CA2411960C (xx)
DK (1) DK1296665T3 (xx)
EA (2) EA200802070A1 (xx)
ES (1) ES2365387T3 (xx)
HK (1) HK1059378A1 (xx)
HU (1) HU229440B1 (xx)
IL (2) IL153303A0 (xx)
MX (1) MXPA02012344A (xx)
NO (1) NO331092B1 (xx)
NZ (1) NZ522957A (xx)
PL (1) PL206268B1 (xx)
PT (1) PT1296665E (xx)
RU (1) RU2003100874A (xx)
WO (1) WO2001095898A1 (xx)
ZA (1) ZA200209944B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001268377B2 (en) * 2000-06-13 2005-07-07 Wyeth Analgesic and anti-inflammatory compositions containing cox-2 inhibitors
CA2476939C (en) * 2002-02-19 2012-08-28 Adcock Ingram Limited Pharmaceutical combinations of cox-2 inhibitors and opiates
US20050058734A1 (en) * 2002-12-18 2005-03-17 Algorx Administration of capsaicinoids
TW200600086A (en) * 2004-06-05 2006-01-01 Astrazeneca Ab Chemical compound
US20060281775A1 (en) 2005-06-14 2006-12-14 Applied Pharmacy Services, Inc. Two-component pharmaceutical composition for the treatment of pain
EP3292866B1 (en) 2006-10-20 2023-07-26 Johnson & Johnson Consumer Inc. Acetaminophen / ibuprofen combinations
TR200904862A1 (tr) * 2009-05-29 2010-12-21 Sanovel İlaç San. Ve Ti̇c. A.Ş. Sukraloz formülasyonu ve üretim prosesi
RU2745196C2 (ru) * 2016-05-27 2021-03-22 Др. Редди'С Лабораторис Лтд. Пероральная композиция целекоксиба для лечения боли

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5331000A (en) * 1992-03-09 1994-07-19 Sepracor Inc. Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
RU2139281C1 (ru) * 1993-11-30 1999-10-10 Джи Ди Сирл энд Компани Пиразолилзамещенный бензолсульфонамид или его фармацевтически приемлемая соль, фармацевтическая композиция, способ лечения от воспаления или связанного с воспалением заболевания
AU3004997A (en) 1996-05-17 1997-12-09 Merck & Co., Inc. Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases
CZ292843B6 (cs) 1996-07-18 2003-12-17 Merck Frosst Canada & Co. Derivát pyridinu a farmaceutický prostředek s jeho obsahem
US6160020A (en) * 1996-12-20 2000-12-12 Mcneill-Ppc, Inc. Alkali metal and alkaline-earth metal salts of acetaminophen
RU2182016C2 (ru) * 1997-03-20 2002-05-10 Панацея Биотек Лтд. Спазмолитическая композиция, способ получения спазмолитической композиции
EP0868915A1 (en) 1997-04-02 1998-10-07 Panacea Biotec Limited An anti-spasmodic and antiinflammatory composition containing a NSAID, pentifenone and fenpiverinium
DZ2479A1 (fr) 1997-05-05 2003-02-01 Pfizer Composés inhibiteurs sélectifs de cox-2 anti-inflammatoires et compositions pharmaceutiques les contenant.
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
FR2770131A1 (fr) * 1997-10-27 1999-04-30 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
JP3844657B2 (ja) 1999-04-14 2006-11-15 パシフィック コーポレイション シクロオキシゲナーゼ−２阻害剤としての４，５−ジアリール−３（２ｈ）−フラノン誘導体
US6524623B1 (en) * 1999-11-12 2003-02-25 Milton Hodosh Therapeutic compositions and methods of use thereof
CA2394232C (en) * 1999-12-22 2009-06-09 Subhash Desai Dual-release compositions of a cyclooxygenase-2-inhibitor
US6306842B1 (en) * 2000-06-02 2001-10-23 Medinox, Inc. Protected forms of a combination of pharmacologically active agents and uses therefor
AU2001268377B2 (en) 2000-06-13 2005-07-07 Wyeth Analgesic and anti-inflammatory compositions containing cox-2 inhibitors

Also Published As

Publication number Publication date
NO20025983L (no) 2003-02-10
AU6837701A (en) 2001-12-24
NO20025983D0 (no) 2002-12-12
CA2411960A1 (en) 2001-12-20
EP1296665B1 (en) 2011-06-08
EP1296665A4 (en) 2005-07-27
US6924303B2 (en) 2005-08-02
BR0111767A (pt) 2003-07-08
US7754753B2 (en) 2010-07-13
EA200802070A1 (ru) 2009-06-30
ATE511844T1 (de) 2011-06-15
RU2003100874A (ru) 2004-06-27
ES2365387T3 (es) 2011-10-03
CN1443067A (zh) 2003-09-17
CA2411960C (en) 2010-10-12
KR20030019422A (ko) 2003-03-06
EA011309B1 (ru) 2009-02-27
NZ522957A (en) 2004-03-26
HK1059378A1 (en) 2004-07-02
JP2004503497A (ja) 2004-02-05
MXPA02012344A (es) 2004-02-26
EA200300692A1 (ru) 2003-12-25
JP5579958B2 (ja) 2014-08-27
ZA200209944B (en) 2003-10-08
DK1296665T3 (da) 2011-07-18
CN100588395C (zh) 2010-02-10
HUP0301348A3 (en) 2005-05-30
PT1296665E (pt) 2011-07-05
NO331092B1 (no) 2011-10-03
US20030216461A1 (en) 2003-11-20
WO2001095898A1 (en) 2001-12-20
PL360469A1 (en) 2004-09-06
IL153303A (en) 2010-11-30
HU229440B1 (en) 2013-12-30
PL206268B1 (pl) 2010-07-30
EP1296665A1 (en) 2003-04-02
AU2001268377B2 (en) 2005-07-07
US20050090538A1 (en) 2005-04-28
HUP0301348A2 (hu) 2003-08-28

Similar Documents

Publication Publication Date Title
BR9907300A (pt) Inibidores do fator xa oxoaza-heterociclila substituìdos
EA200301018A1 (ru) Доставляемая перорально фармацевтическая композиция, включающая активное соединение, содержащее аминосульфонильную группу (ингибитор cox-2), полиэтиленгликоль и улавливающий свободные радикалы антиоксидант
RS49982B (sr) Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
AU646230B2 (en) Pharmaceutical compositions and methods for treating the symptoms of overindulgence
DK1509232T3 (da) Kombination af en NMDA-antagonist og acetylcholin-esterase inhibitorer til behandling af Alzheimers sygdom
GEP20022812B (en) Using Cyclooxygenase-2 Inhibitors for Preparing Medicinal Means to Prevent Cardiovascular Disorders Connected with Inflammation Processes and Pharmaceutical Compositions Containing These Inhibitors
EP1315500A4 (en) PHARMACEUTICAL COMPOSITIONS FOR TOPICAL ADMINISTRATION OF CYCLOOXYGENASE-2 INHIBITORS
AP1780A (en) Use of cox-2 inhibitors for preventing immunodeficiency.
DK1678162T3 (da) P-glycoprotein-inhibitor, fremgangsmåde til fremstilling heraf og farmaceutisk sammensætning omfattende denne
IL153303A0 (en) Analgesic and anti-inflammatory compositions conaining cox-2 inhibitors
WO2005004915A3 (en) Compositions comprising meloxicam
BR0213181A (pt) Combinações de inibidor de cox-2
RS53804A (xx) Parenteralna kompozicija paracetamola
DE60134735D1 (de) Neue neurokinin-antagonisten zum gebrauch als arzneimittel
EE9800230A (et) Difenüülstilbeenid kui COX-2 inhibiitorite eelravimid
HUP0303341A2 (hu) Monoamin-felvétel inhibitora és ezt tartalmazó gyógyszerkészítmények
HUP0301010A2 (hu) A koleszteril-észter és a viaszészter szintézisét egyaránt gátló vegyületek faggyúmirigy-betegségek kezeléséhez és ezeket tartalmazó gyógyszerkészítmények
AU2001244999A1 (en) Naphthamide neurokinin antagonists for use as medicaments
BG108144A (en) New use
AU5750799A (en) Anti-inflammatory pharmaceutical formulations
IS6577A (is) Læknisfræðilega gagnleg ný sölt CCK tálma, aðferðtil að búa þau til og lyfjablöndur sem innihalda þau
WO2001072735A3 (en) Benzopyranes useful as tnf alpha inhibitors
HUP9903928A2 (hu) Fenoxi-etil-amin új származékai,eljárás előállításukra, alkalmazásuk gyógyszerhatóanyagokként és ilyen vegyületeket tartalmazó gyógyászati készítmények
TH22341A (th) " การรักษาโรคการรวมกันสำหรับการติดเชื้อ hiv"
TH104645B (th) ส่วนผสมเชิงเภสัชกรรมตัวใหม่