IL113026A - Selective antagonists of the human nk3 receptor their preparation pharmaceutical compositions containing them and their use for the preparation of phamraceutical compositions - Google Patents

Selective antagonists of the human nk3 receptor their preparation pharmaceutical compositions containing them and their use for the preparation of phamraceutical compositions

Info

Publication number: IL113026A
Authority: IL; Israel
Prior art keywords: alkyl; phenyl; substd; opt; alkoxy
Prior art date: 1994-03-18

Application number

IL11302695A

Other languages

English (en)

Other versions

IL113026A0 (en

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-18

Filing date

1995-03-17

Publication date

1999-06-20

1994-03-18 Priority claimed from FR9403193A external-priority patent/FR2717477B1/fr

1994-07-29 Priority claimed from FR9409478A external-priority patent/FR2717478B1/fr

1995-03-17 Application filed by Sanofi Sa filed Critical Sanofi Sa

1995-06-29 Publication of IL113026A0 publication Critical patent/IL113026A0/xx

1999-06-20 Publication of IL113026A publication Critical patent/IL113026A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

IL11302695A 1994-03-18 1995-03-17 Selective antagonists of the human nk3 receptor their preparation pharmaceutical compositions containing them and their use for the preparation of phamraceutical compositions IL113026A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9403193A FR2717477B1 (fr)	1994-03-18	1994-03-18	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR9409478A FR2717478B1 (fr)	1994-03-18	1994-07-29	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR9500571A FR2719311B1 (fr)	1994-03-18	1995-01-19	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.

Publications (2)

Publication Number	Publication Date
IL113026A0 IL113026A0 (en)	1995-06-29
IL113026A true IL113026A (en)	1999-06-20

Family

ID=27252886

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11302695A IL113026A (en)	1994-03-18	1995-03-17	Selective antagonists of the human nk3 receptor their preparation pharmaceutical compositions containing them and their use for the preparation of phamraceutical compositions

Country Status (23)

Country	Link
US (3)	US5741910A (xx)
EP (1)	EP0673928B1 (xx)
JP (1)	JP2922816B2 (xx)
KR (1)	KR100238343B1 (xx)
CN (1)	CN1056605C (xx)
AT (1)	ATE204863T1 (xx)
AU (1)	AU693845B2 (xx)
CA (1)	CA2145000C (xx)
CY (1)	CY2278B1 (xx)
DE (1)	DE69522355T2 (xx)
DK (1)	DK0673928T3 (xx)
ES (1)	ES2164746T3 (xx)
FI (1)	FI116621B (xx)
FR (1)	FR2719311B1 (xx)
HK (1)	HK1005137A1 (xx)
HU (1)	HUT72065A (xx)
IL (1)	IL113026A (xx)
NO (2)	NO302944B1 (xx)
NZ (1)	NZ270727A (xx)
PL (1)	PL185075B1 (xx)
PT (1)	PT673928E (xx)
RU (1)	RU2143425C1 (xx)
TW (1)	TW380138B (xx)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
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US5824690A (en) *	1993-05-06	1998-10-20	Hoechst Marion Roussel Inc.	Substituted pyrrolidin-3-yl-alkyl-piperidines
US5998444A (en) *	1995-10-24	1999-12-07	Zeneca Ltd.	Piperidinyl compounds as NK1 or NK2 antagonists
EP0714891A1 (en) *	1994-11-22	1996-06-05	Eli Lilly And Company	Heterocyclic tachykinin receptor antagonists
FR2738245B1 (fr) *	1995-08-28	1997-11-21	Sanofi Sa	Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant
FR2738819B1 (fr) *	1995-09-14	1997-12-05	Sanofi Sa	Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
GB9521781D0 (en) *	1995-10-24	1996-01-03	Merck Sharp & Dohme	Therapeutic agents
US6211199B1 (en)	1995-11-17	2001-04-03	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
ATE232858T1 (de) *	1995-11-17	2003-03-15	Aventis Pharma Inc	Substituierte 4-(1h-benzimidazol-2-yl- amino)piperidine zur behandlung allergischer erkrankungen
RU2135494C1 (ru)	1995-12-01	1999-08-27	Санкио Компани Лимитед	Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
US6423704B2 (en)	1995-12-20	2002-07-23	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en)	1995-12-20	2001-02-27	Aventis Pharmaceuticals Inc.	Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
GB9600235D0 (en) *	1996-01-05	1996-03-06	Pfizer Ltd	Therapeutic agents
GB9601697D0 (en) *	1996-01-27	1996-03-27	Pfizer Ltd	Therapeutic agents
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) *	1996-02-21	1999-07-13	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
FR2745811B1 (fr) *	1996-03-07	1998-05-22	Sanofi Sa	Glutarimide disubstitue procede pour sa preparation, et son utilisation
EP0915849A2 (en) *	1996-08-05	1999-05-19	Smithkline Beecham S.p.A.	Process for the preparation of 3,3-disubstituted piperidines
AU4176997A (en) *	1996-09-16	1998-04-02	Warner-Lambert Company	3-alkyl-3-phenyl-piperidines
US6040316A (en) *	1996-09-16	2000-03-21	Warner-Lambert Company	3-alkyl-3-phenyl-piperidines
US5789422A (en) *	1996-10-28	1998-08-04	Schering Corporation	Substituted arylalkylamines as neurokinin antagonists
US5977139A (en) *	1996-12-15	1999-11-02	Hoechst Marion Roussel, Inc.	Carboxysubstituted cyclic carboxamide derivatives
US5861417A (en) *	1996-12-19	1999-01-19	Hoechst Marion Roussel, Inc.	Heterocyclic substituted pyrrolidine amide derivatives
CA2278309A1 (en) *	1997-01-21	1998-07-23	Merck & Co., Inc.	3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6124319A (en) *	1997-01-21	2000-09-26	Merck & Co., Inc.	3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6136827A (en) *	1997-07-25	2000-10-24	Merck & Co., Inc.	Cyclic amine modulations of chemokine receptor activity
AU8576098A (en) *	1997-07-25	1999-02-16	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
WO1999038514A1 (en) *	1998-02-02	1999-08-05	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
US6140349A (en) *	1998-02-02	2000-10-31	Merck & Co., Inc.	Cyclic amine modulators of chemokine receptor activity
US6316445B1 (en)	1998-05-15	2001-11-13	Aventis Pharmaceuticals Inc.	Carboxy substituted acylic carboxamide derivatives
FR2782082B3 (fr) *	1998-08-05	2000-09-22	Sanofi Sa	Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose
FR2784377B3 (fr)	1998-10-09	2000-11-17	Sanofi Sa	Nouveaux composes derives d'ureidopiperidine, antagonistes selectifs des recepteurs nk3 humains, procede pour leur obtention et compositions pharmaceutiques les contenant
FR2787449B3 (fr)	1998-12-15	2001-01-12	Sanofi Sa	Derives de 3-phenyl-2,6-dioxopiperidin-3-yl propionamide et leur procede de preparation
FR2787448B3 (fr)	1998-12-18	2001-01-12	Sanofi Sa	Ester d'alkyle inferieur de l'acide 3-(3,4-dihalogenophenyl) -2,6-dioxopiperidine3-propionique et son mode de preparation
FR2787790A3 (fr) *	1998-12-23	2000-06-30	Sanofi Sa	Procede de preparation du (r)-(+)-3-{1°2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl!-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates
FR2792199B3 (fr)	1999-04-13	2001-05-18	Sanofi Sa	Utilisation de l'osanetant pour la preparation de medicaments utiles dans le traitement des troubles de l'humeur
GB9927125D0 (en) *	1999-11-16	2000-01-12	Univ Reading The	Placental human neurokinin B precursor
AU2002219846A1 (en) *	2000-11-16	2002-05-27	Smith Kline Beecham Corporation	Novel use
MXPA03009353A (es) *	2001-04-12	2004-02-12	Pharmacopeia Inc	Aril y biaril piperidinas utilizadas como antagonistas de mch.
US20040152727A1 (en) *	2001-05-18	2004-08-05	Hay Douglas William Pierre	Novel use
MY134211A (en) *	2001-05-18	2007-11-30	Smithkline Beecham Corp	Novel use
GB0208897D0 (en) *	2002-04-18	2002-05-29	Merck Sharp & Dohme	New method of treatment
JP2005538047A (ja) *	2002-05-03	2005-12-15	ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー	ボンベシンアンタゴニスト
CN1852712B (zh) *	2003-07-03	2010-06-09	弗·哈夫曼-拉罗切有限公司	用于治疗精神分裂症的双重nk1/nk3拮抗剂
US7834008B2 (en)	2003-08-15	2010-11-16	H. Lundbeck A/S	Cyclopropyl derivatives as NK3 receptor antagonists
KR20060066721A (ko) *	2003-08-15	2006-06-16	하. 룬트벡 아크티에 셀스카브	Ｎｋ3 수용체 길항제로서의 시클로프로필 유도체
GB0513747D0 (en) *	2005-07-06	2005-08-10	Merck Sharp & Dohme	Therapeutic compounds
TW200804288A (en)	2005-12-12	2008-01-16	Astrazeneca Ab	Alkylsulphonamide quinolines
RU2442782C2 (ru) *	2006-07-20	2012-02-20	Новартис Аг	Производные аминопиперидина как ингибиторы бпхэ (белка-переносчика холестерилового эфира)
WO2009011872A1 (en)	2007-07-17	2009-01-22	Merck & Co., Inc.	Soluble epoxide hydrolase inhibitors, compositions containing such compounds and methods of treatment
EP2986293A1 (en)	2013-04-19	2016-02-24	Astrazeneca AB	A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
WO2019090001A1 (en)	2017-11-02	2019-05-09	California Institute Of Technology	Neurokinin antagonists and uses thereof
CN113603630B (zh) *	2021-08-10	2023-06-27	苏州小栗医药科技有限公司	一种4-苯基哌啶盐酸盐的合成方法

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* Cited by examiner, † Cited by third party
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IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2676053B1 (fr) *	1991-05-03	1993-08-27	Sanofi Elf	Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676054B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) *	1992-03-03	1994-07-08	Sanofi Elf	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) *	1992-11-03	1993-12-08	Zeneca Ltd	Carboxamide derivatives
GB9310713D0 (en) *	1993-05-24	1993-07-07	Zeneca Ltd	Aryl substituted heterocycles
EP0714891A1 (en) *	1994-11-22	1996-06-05	Eli Lilly And Company	Heterocyclic tachykinin receptor antagonists

1995
- 1995-01-19 FR FR9500571A patent/FR2719311B1/fr not_active Expired - Fee Related
- 1995-03-16 NZ NZ270727A patent/NZ270727A/en not_active IP Right Cessation
- 1995-03-16 PL PL95307723A patent/PL185075B1/pl not_active IP Right Cessation
- 1995-03-17 DE DE69522355T patent/DE69522355T2/de not_active Expired - Lifetime
- 1995-03-17 AT AT95400590T patent/ATE204863T1/de not_active IP Right Cessation
- 1995-03-17 ES ES95400590T patent/ES2164746T3/es not_active Expired - Lifetime
- 1995-03-17 AU AU14909/95A patent/AU693845B2/en not_active Ceased
- 1995-03-17 HU HU9500806A patent/HUT72065A/hu unknown
- 1995-03-17 RU RU95103737/04A patent/RU2143425C1/ru active
- 1995-03-17 IL IL11302695A patent/IL113026A/xx not_active IP Right Cessation
- 1995-03-17 PT PT95400590T patent/PT673928E/pt unknown
- 1995-03-17 FI FI951265A patent/FI116621B/fi active IP Right Grant
- 1995-03-17 EP EP95400590A patent/EP0673928B1/fr not_active Expired - Lifetime
- 1995-03-17 DK DK95400590T patent/DK0673928T3/da active
- 1995-03-17 CN CN95103542A patent/CN1056605C/zh not_active Expired - Fee Related
- 1995-03-17 NO NO951044A patent/NO302944B1/no not_active IP Right Cessation
- 1995-03-18 TW TW084102614A patent/TW380138B/zh not_active IP Right Cessation
- 1995-03-18 KR KR1019950005722A patent/KR100238343B1/ko not_active IP Right Cessation
- 1995-03-20 CA CA002145000A patent/CA2145000C/en not_active Expired - Fee Related
- 1995-03-20 JP JP7061419A patent/JP2922816B2/ja not_active Expired - Fee Related
1996
- 1996-02-29 US US08/607,976 patent/US5741910A/en not_active Expired - Lifetime
- 1996-02-29 US US08/608,718 patent/US5942523A/en not_active Expired - Lifetime
1997
- 1997-11-04 NO NO975089A patent/NO303823B1/no not_active IP Right Cessation
1998
- 1998-05-19 HK HK98104342A patent/HK1005137A1/xx not_active IP Right Cessation
1999
- 1999-05-07 US US09/306,825 patent/US6124316A/en not_active Expired - Fee Related
2002
- 2002-05-15 CY CY0200032A patent/CY2278B1/xx unknown

Also Published As

Publication number	Publication date
EP0673928B1 (fr)	2001-08-29
IL113026A0 (en)	1995-06-29
HK1005137A1 (en)	1998-12-24
FR2719311A1 (fr)	1995-11-03
US5741910A (en)	1998-04-21
ATE204863T1 (de)	2001-09-15
AU693845B2 (en)	1998-07-09
ES2164746T3 (es)	2002-03-01
AU1490995A (en)	1995-09-28
DE69522355T2 (de)	2002-05-23
FI116621B (fi)	2006-01-13
JPH0848669A (ja)	1996-02-20
NO951044D0 (no)	1995-03-17
TW380138B (en)	2000-01-21
NO975089L (no)	1995-09-19
NO302944B1 (no)	1998-05-11
RU2143425C1 (ru)	1999-12-27
CN1128756A (zh)	1996-08-14
NZ270727A (en)	1997-05-26
FI951265A (fi)	1995-09-19
KR950032120A (ko)	1995-12-20
KR100238343B1 (ko)	2000-03-02
PT673928E (pt)	2002-02-28
PL307723A1 (en)	1995-10-02
FI951265A0 (fi)	1995-03-17
FR2719311B1 (fr)	1998-06-26
CA2145000C (en)	2002-05-07
EP0673928A1 (fr)	1995-09-27
HU9500806D0 (en)	1995-05-29
CN1056605C (zh)	2000-09-20
US6124316A (en)	2000-09-26
JP2922816B2 (ja)	1999-07-26
RU95103737A (ru)	1997-04-27
PL185075B1 (pl)	2003-02-28
DE69522355D1 (de)	2001-10-04
US5942523A (en)	1999-08-24
NO303823B1 (no)	1998-09-07
HUT72065A (en)	1996-03-28
NO951044L (no)	1995-09-19
NO975089D0 (no)	1997-11-04
CY2278B1 (en)	2003-07-04
CA2145000A1 (en)	1995-09-19
DK0673928T3 (da)	2001-11-12

Publication	Publication Date	Title
IL113026A (en)	1999-06-20	Selective antagonists of the human nk3 receptor their preparation pharmaceutical compositions containing them and their use for the preparation of phamraceutical compositions
HUT75113A (en)	1997-04-28	4-substituted piperidine derivatives useful as neurokinin antagonists
UA27100A1 (uk)	2000-02-28	Заміщеhі піроли, що мають активhість іhгібіторів протеіhкіhази с, а також їх фармацевтичhо прийhятhі кислотhо-адитивhі солі і фармацевтичhа композиція
NZ502209A (en)	2001-01-26	Gastrokinetic bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
HUT58313A (en)	1992-02-28	Process for producing pyrrolidine derivatives and pharmaceutical compositions containing them
HUT76644A (en)	1997-10-28	Substituted piperidines, pharmaceutical compositions containing them and their use
WO1993014084A3 (en)	1993-10-14	Piperidine derivatives
BG98793A (en)	1995-04-28	Animoacid derivatives, method for their preparation and pharmaceutical composition containing them
IL114894A (en)	2003-04-10	Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments
UA50762C2 (uk)	2002-11-15	Похідні арилгліцинаміду та фармацевтична композиція
BG94282A (bg)	1993-12-24	2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
MD522G2 (ro)	1997-01-31	Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice
YU50590A (sh)	1993-05-28	Supstituisani derivati azetidinil piridon karbonskih kiselina i postupak za njihovu izradu
IL61911A0 (en)	1981-02-27	2,3-dihydro-imidazo(1,2-b)pyridazine derivatives,their preparation and pharmaceutical compositions containing them
HUP9701383A2 (hu)	1999-06-28	Új 8-metil-7H-1,3-dioxolo[4,5h][2,3]-benzodiazepin-származékok, ilyen hatóanyagot tartalmazó gyógyászati készítmény, és eljárás a hatóanyag előállítására
MX9709079A (es)	1998-01-31	Derivados de 1-benzol-2-(indolil-3-alquil) piperazina como antagonistas del receptor de neuroquinina.

Legal Events

Date	Code	Title
1999-10-28	FF	Patent granted
2000-08-13	KB	Patent renewed
2001-06-14	KB	Patent renewed
2002-02-10	HC	Change of name of proprietor(s)
2005-05-17	KB	Patent renewed
2009-08-31	KB	Patent renewed
2013-10-31	MM9K	Patent not in force due to non-payment of renewal fees