IL117265A - Benzazepine- benzoxazepine- and benzothiazepine-N-acetic acid derivatives their preparation and pharmaceutical compositions containing them - Google Patents
Benzazepine- benzoxazepine- and benzothiazepine-N-acetic acid derivatives their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL117265A IL117265A IL11726596A IL11726596A IL117265A IL 117265 A IL117265 A IL 117265A IL 11726596 A IL11726596 A IL 11726596A IL 11726596 A IL11726596 A IL 11726596A IL 117265 A IL117265 A IL 117265A
- Authority
- IL
- Israel
- Prior art keywords
- benzoxazepine
- benzothiazepine
- benzazepine
- preparation
- acetic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19510566A DE19510566A1 (de) | 1995-03-23 | 1995-03-23 | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
IL117265A0 IL117265A0 (en) | 1996-06-18 |
IL117265A true IL117265A (en) | 2000-07-16 |
Family
ID=7757471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11726596A IL117265A (en) | 1995-03-23 | 1996-02-26 | Benzazepine- benzoxazepine- and benzothiazepine-N-acetic acid derivatives their preparation and pharmaceutical compositions containing them |
Country Status (25)
Country | Link |
---|---|
US (1) | US5677297A (xx) |
EP (1) | EP0733642B1 (xx) |
JP (1) | JP3942670B2 (xx) |
KR (1) | KR100482499B1 (xx) |
CN (1) | CN1059436C (xx) |
AR (1) | AR023289A1 (xx) |
AT (1) | ATE197801T1 (xx) |
AU (1) | AU701271B2 (xx) |
CA (1) | CA2172354C (xx) |
CZ (1) | CZ289245B6 (xx) |
DE (2) | DE19510566A1 (xx) |
DK (1) | DK0733642T3 (xx) |
DZ (1) | DZ2003A1 (xx) |
ES (1) | ES2152444T3 (xx) |
GR (1) | GR3035410T3 (xx) |
HU (1) | HU226064B1 (xx) |
IL (1) | IL117265A (xx) |
NO (1) | NO305904B1 (xx) |
NZ (1) | NZ286224A (xx) |
PL (1) | PL184336B1 (xx) |
PT (1) | PT733642E (xx) |
RU (1) | RU2159768C2 (xx) |
SK (1) | SK281079B6 (xx) |
UA (1) | UA44712C2 (xx) |
ZA (1) | ZA961243B (xx) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19510566A1 (de) * | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE19638020A1 (de) * | 1996-09-18 | 1998-03-19 | Solvay Pharm Gmbh | Die gastrointestinale Durchblutung fördernde Arzneimittel |
DE19750002A1 (de) * | 1997-11-12 | 1999-05-20 | Solvay Pharm Gmbh | Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
FR2781483A1 (fr) * | 1998-07-21 | 2000-01-28 | Hoechst Marion Roussel Inc | Derives de thioazepinone, procede de preparation et intermediaires de ce procede, application a titre de medicament et compositions pharmaceutiques les renfermant |
DE19906310A1 (de) * | 1999-02-16 | 2000-08-17 | Solvay Pharm Gmbh | Arzneimittel zur Behandlung von Bluthochdruck |
DE19932555A1 (de) | 1999-07-13 | 2001-01-18 | Solvay Pharm Gmbh | Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen |
US20020052370A1 (en) * | 2000-07-06 | 2002-05-02 | Barber Christopher Gordon | Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase |
SK14102003A3 (sk) * | 2001-05-18 | 2004-08-03 | Solvay Pharmaceuticals Gmbh | Použitie zlúčenín s kombinovanou inhibičnou aktivitou k NEP/MP pri príprave liečiv |
AU2002333809C1 (en) * | 2001-09-10 | 2009-02-05 | Janssen Sciences Ireland Unlimited Company | Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol |
KR100710547B1 (ko) * | 2002-01-02 | 2007-04-24 | 에스케이 주식회사 | (s)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1H-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법 |
MXPA04006887A (es) * | 2002-01-16 | 2004-12-06 | Solvay Pharm Bv | Sales solidas de compuestos de benzazepina y su uso en la preparacion de compuestos farmaceuticos. |
AR038681A1 (es) * | 2002-02-14 | 2005-01-26 | Solvay Pharm Bv | Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua |
US6842358B2 (en) * | 2002-08-01 | 2005-01-11 | Netlogic Microsystems, Inc. | Content addressable memory with cascaded array |
US7045653B2 (en) * | 2002-12-23 | 2006-05-16 | Pfizer, Inc. | Pharmaceuticals |
KR100710548B1 (ko) * | 2002-12-26 | 2007-04-24 | 에스케이 주식회사 | (s)-3-아미노-2,3,4,5-테트라히드로-2-옥소-1H-1-벤자제핀-1-아세트산 및 이의 에스테르 화합물의 제조방법 |
SA04250283B1 (ar) * | 2003-09-26 | 2008-05-26 | سولفاي فارماسيتيكالز جي أم بي أتش | مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid |
US7427611B2 (en) | 2003-09-26 | 2008-09-23 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them |
US7452875B2 (en) | 2003-09-26 | 2008-11-18 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them |
US7262184B2 (en) | 2003-09-26 | 2007-08-28 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them |
DE10344848A1 (de) * | 2003-09-26 | 2005-04-14 | Solvay Pharmaceuticals Gmbh | Amidomethyl-substituierte l-(Carboxyalkyl)-cyclopentylcarbonylamino-benzazepin-N-essigsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enhaltende Arzneimittel |
CA2545802A1 (en) * | 2003-11-18 | 2005-06-02 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions for the treatment of renal dysfunction, disease or disorder, in particular in diabetic patients |
CN101076339B (zh) * | 2004-01-12 | 2011-02-09 | 索尔瓦药物有限公司 | 用于预防和治疗神经变性疾病的中性内肽酶(NEP)和人可溶内肽酶(hSEP)抑制剂 |
US7232813B2 (en) * | 2004-01-12 | 2007-06-19 | Solvay Pharmaceuticals B.V. | Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neuro-degenerative disorders |
US20050267072A1 (en) * | 2004-05-14 | 2005-12-01 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction |
US20050267124A1 (en) * | 2004-05-14 | 2005-12-01 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors |
AU2005256634B2 (en) * | 2004-06-23 | 2010-12-09 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1-receptor antagonists |
US20050288272A1 (en) * | 2004-06-23 | 2005-12-29 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists |
CN101080232A (zh) | 2004-12-15 | 2007-11-28 | 索尔瓦药物有限公司 | 包含NEP-抑制剂、内源性内皮素产生系统的抑制剂和HMG CoA还原酶抑制剂的药物组合物 |
TW200633713A (en) * | 2004-12-23 | 2006-10-01 | Solvay Pharm Bv | Oral immediate release formulation of a poorly water-soluble active substance |
US20060159748A1 (en) * | 2004-12-23 | 2006-07-20 | Rajesh Jain | Oral immediate release formulation of a poorly water-soluble active substance |
US20060205625A1 (en) * | 2005-02-18 | 2006-09-14 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics |
WO2007102171A2 (en) * | 2006-03-07 | 2007-09-13 | Panacea Biotec Ltd | Novel salts of 1h-1-benzazepine-1-acetic acid, their preparation and pharmaceutical composition |
US20070292503A1 (en) * | 2006-06-16 | 2007-12-20 | Gorissen Henricus R | Oral pharmaceutical composition of poorly water-soluble active substance |
US20070299054A1 (en) * | 2006-06-22 | 2007-12-27 | Rajesh Jain | Oral pharmaceutical composition of a poorly water-soluble active agent |
EP2234608A2 (en) | 2007-12-11 | 2010-10-06 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
EP2434895A4 (en) | 2009-05-13 | 2013-08-07 | Intra Cellular Therapies Inc | ORGANIC CONNECTIONS |
AR079059A1 (es) | 2009-12-07 | 2011-12-21 | Abbott Healthcare Products Bv | Acido ((3s)-3-(((1-(((2r)-2-carboxi-4-(1-naftil) butil) ciclopentil)-carbonil) amino )-2-oxo-2,3,4,5-tetrahidro-1h-1-benzazepin-1-il) acetico cristalino, su preparacion y uso |
EP2939677A1 (en) | 2010-09-01 | 2015-11-04 | Arena Pharmaceuticals, Inc. | Administration of lorcaserin to indviduals with renal impairment |
KR101913442B1 (ko) | 2010-09-01 | 2018-10-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리에 유용한 5-ht2c 작동제의 변형-방출 투여 형태 |
US8993631B2 (en) | 2010-11-16 | 2015-03-31 | Novartis Ag | Method of treating contrast-induced nephropathy |
NZ610983A (en) | 2010-12-15 | 2014-10-31 | Theravance Biopharma R & D Ip Llc | Neprilysin inhibitors |
EP2651900B1 (en) | 2010-12-15 | 2015-08-19 | Theravance Biopharma R&D IP, LLC | Neprilysin inhibitors |
MX342212B (es) | 2011-02-17 | 2016-09-20 | Theravance Inc | Inhibidores de neprilisina. |
JP5959066B2 (ja) | 2011-02-17 | 2016-08-02 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
JP5885832B2 (ja) | 2011-05-31 | 2016-03-16 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | ネプリライシン阻害剤 |
US8513244B2 (en) | 2011-05-31 | 2013-08-20 | Theravance, Inc. | Neprilysin inhibitors |
CA2835220A1 (en) | 2011-05-31 | 2012-12-06 | Theravance, Inc. | Neprilysin inhibitors |
TWI560172B (en) | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
CN104350052B (zh) | 2012-05-31 | 2017-05-31 | 施万生物制药研发Ip有限责任公司 | 一氧化氮供体脑啡肽酶抑制剂 |
LT2864292T (lt) | 2012-06-08 | 2017-07-10 | Theravance Biopharma R&D Ip, Llc | Neprilizino inhibitoriai |
CN104470521B (zh) | 2012-06-08 | 2017-04-12 | 施万生物制药研发Ip有限责任公司 | 脑啡肽酶抑制剂 |
BR112015002821B1 (pt) | 2012-08-08 | 2022-10-18 | Theravance Biopharma R&D Ip, Llc | Compostos inibidores de neprilisina e composição farmacêutica |
EP2956141A4 (en) | 2013-02-17 | 2016-10-26 | Intra Cellular Therapies Inc | NEW USES |
PT2964616T (pt) | 2013-03-05 | 2017-08-08 | Theravance Biopharma R&D Ip Llc | Inibidores da neprilisina |
SG11201606057PA (en) | 2014-01-30 | 2016-08-30 | Theravance Biopharma R&D Ip Llc | 5-biphenyl-4-heteroarylcarbonylamino-pentanoic acid derivatives as neprilysin inhibitors |
AU2015210983B2 (en) | 2014-01-30 | 2018-10-04 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
ES2745819T3 (es) | 2014-08-07 | 2020-03-03 | Intra Cellular Therapies Inc | Derivados de imidazo[1,2-a]-pirazolo[4,3-e]-pirimidin-4-ona con actividad inhibidora de la PDE1 |
KR102345318B1 (ko) | 2014-12-02 | 2021-12-31 | 현대모비스 주식회사 | 에이밍 보정 구조를 구비한 차량용 램프 |
CA2974741C (en) | 2015-02-11 | 2022-10-18 | Theravance Biopharma R&D Ip, Llc | (2s,4r)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-4-(ethoxyoxalylamino)-2-hydroxymethyl-2-methylpentanoic acid as neprilysin inhibitor |
AU2016220348B2 (en) | 2015-02-19 | 2019-10-17 | Theravance Biopharma R&D Ip, Llc | (2R,4R)-5-(5'-chloro-2'-fluorobiphenyl-4-yl)-2-hydroxy-4-[(5-methyloxazole-2-carbonyl)amino]pentanoic acid |
CN105017154B (zh) * | 2015-07-07 | 2017-10-10 | 浙江博聚新材料有限公司 | 一种3‑溴‑1,3,4,5‑四氢‑2h‑1‑苯并氮杂卓‑2‑酮制备方法 |
RU2756223C2 (ru) | 2016-03-08 | 2021-09-28 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | Кристаллическая (2s,4r)-5-(5'-хлор-2'-фтор-[1,1'-бифенил]-4-ил)-2-(этоксиметил)-4-(3-гидроксиизоксазол-5-карбоксамидо)-2-метилпентановая кислота и ее применения |
WO2017172795A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
US11839614B2 (en) | 2018-01-31 | 2023-12-12 | Intra-Cellular Therapies, Inc. | Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine A2 signaling and/or adenosine A2 receptor expression |
PL424453A1 (pl) * | 2018-01-31 | 2019-08-12 | Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością | Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) |
PL424452A1 (pl) | 2018-01-31 | 2019-08-12 | Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu |
US20230118503A1 (en) * | 2020-07-19 | 2023-04-20 | Christopher Turski | NEUTRAL ENDOPEPTIDASE (NEP) AND HUMAN SOLUBLE ENDOPEPTIDASE (hSEP) INHIBITORS FOR PROPHYLAXIS AND TREATMENT OF EYE DISEASES |
Family Cites Families (8)
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JPS608283A (ja) * | 1983-06-29 | 1985-01-17 | Mitsui Toatsu Chem Inc | ベンゾチアゼピン誘導体およびその製造方法 |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
IT1266570B1 (it) * | 1993-07-30 | 1997-01-09 | Zambon Spa | Derivati della propanammide n-eteroaril sostituiti utili nel trattamento delle malattie cardiovascolari |
IT1266571B1 (it) * | 1993-07-30 | 1997-01-09 | Zambon Spa | Derivati della beta-mercapto-propanammide utili nel trattamento delle malattie cardiovascolari |
DE19510566A1 (de) * | 1995-03-23 | 1996-09-26 | Kali Chemie Pharma Gmbh | Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
-
1995
- 1995-03-23 DE DE19510566A patent/DE19510566A1/de not_active Withdrawn
-
1996
- 1996-02-16 ZA ZA961243A patent/ZA961243B/xx unknown
- 1996-02-26 IL IL11726596A patent/IL117265A/xx not_active IP Right Cessation
- 1996-03-11 AR ARP960101698A patent/AR023289A1/es active IP Right Grant
- 1996-03-15 SK SK354-96A patent/SK281079B6/sk not_active IP Right Cessation
- 1996-03-17 DZ DZ960044A patent/DZ2003A1/fr active
- 1996-03-18 DE DE59606160T patent/DE59606160D1/de not_active Expired - Lifetime
- 1996-03-18 DK DK96104265T patent/DK0733642T3/da active
- 1996-03-18 ES ES96104265T patent/ES2152444T3/es not_active Expired - Lifetime
- 1996-03-18 EP EP96104265A patent/EP0733642B1/de not_active Expired - Lifetime
- 1996-03-18 PT PT96104265T patent/PT733642E/pt unknown
- 1996-03-18 HU HU9600680A patent/HU226064B1/hu not_active IP Right Cessation
- 1996-03-18 AT AT96104265T patent/ATE197801T1/de active
- 1996-03-20 NZ NZ286224A patent/NZ286224A/en not_active IP Right Cessation
- 1996-03-20 RU RU96105383/04A patent/RU2159768C2/ru not_active IP Right Cessation
- 1996-03-20 CN CN96104257A patent/CN1059436C/zh not_active Expired - Fee Related
- 1996-03-21 CA CA002172354A patent/CA2172354C/en not_active Expired - Lifetime
- 1996-03-21 KR KR1019960007794A patent/KR100482499B1/ko not_active IP Right Cessation
- 1996-03-21 AU AU48210/96A patent/AU701271B2/en not_active Ceased
- 1996-03-22 CZ CZ1996863A patent/CZ289245B6/cs not_active IP Right Cessation
- 1996-03-22 US US08/620,213 patent/US5677297A/en not_active Expired - Lifetime
- 1996-03-22 UA UA96031113A patent/UA44712C2/uk unknown
- 1996-03-22 JP JP06670396A patent/JP3942670B2/ja not_active Expired - Fee Related
- 1996-03-22 NO NO961181A patent/NO305904B1/no not_active IP Right Cessation
- 1996-03-22 PL PL96313433A patent/PL184336B1/pl not_active IP Right Cessation
-
2001
- 2001-02-14 GR GR20010400240T patent/GR3035410T3/el unknown
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