Nothing Special   »   [go: up one dir, main page]

IE780841L - Kanamycin derivatives - Google Patents

Kanamycin derivatives

Info

Publication number
IE780841L
IE780841L IE780841A IE84178A IE780841L IE 780841 L IE780841 L IE 780841L IE 780841 A IE780841 A IE 780841A IE 84178 A IE84178 A IE 84178A IE 780841 L IE780841 L IE 780841L
Authority
IE
Ireland
Prior art keywords
amino
formula
image
kanamycin
protective group
Prior art date
Application number
IE780841A
Other versions
IE46945B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE780841L publication Critical patent/IE780841L/en
Publication of IE46945B1 publication Critical patent/IE46945B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1-N-[ omega -amino- alpha -hydroxyalkanoyl] kanamycins A and B of the formula I <IMAGE> in which R represents OH or NH2, are prepared by acylation of polysilylated kanamycin A or B, or polysilylated kanamycin A or B which has a protective group other than silyl on the 6'-amino group, with an acylating derivative of an acid of the formula II <IMAGE> in which n is an integer from 0 to 2 and B is an amino protective group, in an essentially anhydrous organic solvent and by subsequent removal of all blocking groups. The compounds have therapeutic properties. [GB1598294A]
IE841/78A 1977-04-28 1978-04-27 Process for the preparation of kanamycin derivatives IE46945B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79180677A 1977-04-28 1977-04-28
US88858578A 1978-03-20 1978-03-20

Publications (2)

Publication Number Publication Date
IE780841L true IE780841L (en) 1978-10-28
IE46945B1 IE46945B1 (en) 1983-11-16

Family

ID=27121201

Family Applications (2)

Application Number Title Priority Date Filing Date
IE842/78A IE47271B1 (en) 1977-04-28 1978-04-27 Process for the preparation of 1-n-acyl-aminoglycosides
IE841/78A IE46945B1 (en) 1977-04-28 1978-04-27 Process for the preparation of kanamycin derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IE842/78A IE47271B1 (en) 1977-04-28 1978-04-27 Process for the preparation of 1-n-acyl-aminoglycosides

Country Status (27)

Country Link
JP (1) JPS53149951A (en)
AR (1) AR218910A1 (en)
AT (1) AT357675B (en)
CA (2) CA1100953A (en)
CH (1) CH639104A5 (en)
CS (1) CS207607B2 (en)
CY (1) CY1241A (en)
DE (2) DE2818992A1 (en)
DK (2) DK165450C (en)
EG (1) EG13710A (en)
ES (1) ES469303A1 (en)
FI (1) FI781288A (en)
FR (2) FR2388826A1 (en)
GB (1) GB1598294A (en)
HK (1) HK51484A (en)
IE (2) IE47271B1 (en)
IT (2) IT1156718B (en)
KE (1) KE3398A (en)
LU (1) LU79541A1 (en)
MY (1) MY8500528A (en)
NL (1) NL178790C (en)
NO (2) NO149635C (en)
PL (1) PL117307B1 (en)
PT (1) PT67959B (en)
SE (2) SE447259B (en)
SG (1) SG22884G (en)
YU (2) YU102578A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55306A (en) * 1978-04-28 1980-01-05 Bristol Myers Co Manufacture of 11nn*omegaaaminooalphaahydroxy alkanoyl**aminoglycoside antibiotic
JP4621429B2 (en) * 2002-02-19 2011-01-26 学校法人東海大学 Lactic acid derivatives
AU2008326297B2 (en) 2007-11-21 2012-11-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs

Also Published As

Publication number Publication date
JPS53149951A (en) 1978-12-27
DE2818992A1 (en) 1978-11-23
NO154697C (en) 1986-12-03
DE2818992C2 (en) 1988-03-17
SE8305538D0 (en) 1983-10-07
CA1100953A (en) 1981-05-12
CS207607B2 (en) 1981-08-31
SE447259B (en) 1986-11-03
AT357675B (en) 1980-07-25
JPS5721277B2 (en) 1982-05-06
PL117307B1 (en) 1981-07-31
YU102478A (en) 1982-10-31
FR2388826A1 (en) 1978-11-24
NL178790B (en) 1985-12-16
IE780842L (en) 1978-10-28
DK182978A (en) 1978-10-29
GB1598294A (en) 1981-09-16
DK172543B1 (en) 1998-12-07
FR2388826B1 (en) 1982-12-10
DK183078A (en) 1978-10-29
PT67959B (en) 1980-03-05
FR2388827A1 (en) 1978-11-24
SE461148B (en) 1990-01-15
IE46945B1 (en) 1983-11-16
SE7804973L (en) 1978-10-29
NO149635B (en) 1984-02-13
DE2818822C2 (en) 1989-01-26
NO781437L (en) 1978-10-31
AR218910A1 (en) 1980-07-15
PL206457A1 (en) 1980-03-24
NL178790C (en) 1986-05-16
SG22884G (en) 1985-01-04
EG13710A (en) 1982-09-30
HK51484A (en) 1984-06-22
DE2818822A1 (en) 1978-11-09
KE3398A (en) 1984-06-08
IT7849136A0 (en) 1978-04-28
YU102578A (en) 1983-01-21
CY1241A (en) 1984-06-29
IT1105500B (en) 1985-11-04
IT1156718B (en) 1987-02-04
CH639104A5 (en) 1983-10-31
ATA312778A (en) 1979-12-15
IT7849137A0 (en) 1978-04-28
MY8500528A (en) 1985-12-31
ES469303A1 (en) 1979-09-16
PT67959A (en) 1978-05-01
FI781288A (en) 1978-10-29
DK165450B (en) 1992-11-30
CA1105454A (en) 1981-07-21
YU41590B (en) 1987-12-31
NO831197L (en) 1978-10-31
NO154697B (en) 1986-08-25
NO149635C (en) 1984-05-23
SE8305538L (en) 1983-10-07
DK165450C (en) 1993-04-13
NL7804503A (en) 1978-10-31
IE47271B1 (en) 1984-02-08
LU79541A1 (en) 1978-11-28
FR2388827B1 (en) 1982-07-09

Similar Documents

Publication Publication Date Title
IE780841L (en) Kanamycin derivatives
IE45030L (en) Aminoglycoside antibiotics and their intermediates
ES442144A1 (en) 4{40 -Epi-6{40 -hydroxyadriamycin and method of use
AU544923B2 (en) Peptides
IE42179L (en) Kanamycin derivatives
JPS5540621A (en) Novel aminoglycoside derivative
JPS5488242A (en) Novel derivative of fortimicin b and its preparation
ES8506749A1 (en) 1N-(omega-amino-alpha-hydroxyalkanoyl)-2&#39;,3&#39;-dideoxykanamycin A and the production of the same.
JPS55329A (en) Novel xk-62-4 derivative
JPS5581897A (en) Preparation of 1-n-isoseryl-or 1-n-(l-4-amino-2-hydroxybutyryl)-3&#39;,4&#39;-dideoxykanamycin b
GB1475481A (en) 1-n-alpha-hydroxy-omega-aminoalkanoyl-6-n-methyl-3,4-dideoxy kanamycin b and the production thereof
ES8605802A1 (en) Cinnamoyl compounds, process for their preparation and their therapeutical use
JPS6461494A (en) Production of 5&#39;-0-acyl-5-fluorouridine derivative
ES404747A1 (en) Derivatives of kanamycin a and b and a process for the preparation thereof
GB1387080A (en) Antibiotics and the preparation thereof
JPS55120516A (en) Antitumor drug comprising organic silicon compound as chief ingredient
EP0098032A3 (en) Beta-lactam derivatives and their pharmaceutical preparations
JPS5753496A (en) 1-n-acyl derivative of 5,3&#39;,4&#39;-trideoxykanamycin b or 5,3&#39;,4&#39;,6&#39;- tetradeoxykanamycin b, and their preparation
IE830144L (en) Anthracycline glycosides
JPS572282A (en) Synthesis of fortimicins
JPS5651499A (en) Aminoglycoside derivative and its preparation
ES435375A1 (en) Derivative of antibiotic xk-62-2 and method of production thereof
GB1463149A (en) Intermediates for the preparation of 2-deoxystreptamine- aminoglycosides
JPS5643296A (en) Novel aminoglycoside derivative
JPS5610198A (en) Phosphonic acid derivative

Legal Events

Date Code Title Description
MK9A Patent expired