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IE41199B1 - 1,5(6)-disubstituted benzimidazole-2-carbamate derivativeshaving anthelmintic activity - Google Patents

1,5(6)-disubstituted benzimidazole-2-carbamate derivativeshaving anthelmintic activity

Info

Publication number
IE41199B1
IE41199B1 IE1434/74A IE143474A IE41199B1 IE 41199 B1 IE41199 B1 IE 41199B1 IE 1434/74 A IE1434/74 A IE 1434/74A IE 143474 A IE143474 A IE 143474A IE 41199 B1 IE41199 B1 IE 41199B1
Authority
IE
Ireland
Prior art keywords
derivativeshaving
carbamate
denotes
anthelmintic activity
benzimidazole
Prior art date
Application number
IE1434/74A
Other versions
IE41199L (en
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US473865A external-priority patent/US3929822A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IE41199L publication Critical patent/IE41199L/en
Publication of IE41199B1 publication Critical patent/IE41199B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)

Abstract

Compounds of the formula <IMAGE> wherein R denotes C1-C4-alkyl, R<1> denotes various ether, thioether, sulphinyl and sulphonyl groups and R<8> denotes aryl, aralkyl or C1-C12-alkyl, which can be substituted by (C1-C4-alkoxy)-carbonyl, are prepared by reaction of a corresponding benzimidazole, which is however unsubstituted in the 1-position, with an isocyanate OCNR. The compounds and their salts with acids possess a broad-band activity against parasites of mammals, especially against helminths, and can be used for the treatment of corresponding infections of the digestive tract. [GB1480722A]
IE1434/74A 1974-05-28 1974-07-05 1,5(6)-disubstituted benzimidazole-2-carbamate derivativeshaving anthelmintic activity IE41199B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US473865A US3929822A (en) 1972-12-29 1974-05-28 1,5(6)-Disubstituted benzizimidazole-2-carbamate derivatives having anthelmintic activity

Publications (2)

Publication Number Publication Date
IE41199L IE41199L (en) 1975-11-28
IE41199B1 true IE41199B1 (en) 1979-11-07

Family

ID=23881335

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1434/74A IE41199B1 (en) 1974-05-28 1974-07-05 1,5(6)-disubstituted benzimidazole-2-carbamate derivativeshaving anthelmintic activity

Country Status (21)

Country Link
JP (1) JPS50155612A (en)
AR (1) AR221575A1 (en)
AT (1) AT337714B (en)
BE (1) BE817164Q (en)
BR (1) BR7406197A (en)
CH (1) CH614943A5 (en)
CS (1) CS222211B2 (en)
DD (1) DD115494A6 (en)
DE (1) DE2431093C2 (en)
DK (1) DK155005C (en)
ES (1) ES430794A1 (en)
GB (1) GB1480722A (en)
HU (1) HU169779B (en)
IE (1) IE41199B1 (en)
IT (1) IT1046279B (en)
PL (1) PL100057B1 (en)
RO (1) RO64921A (en)
SE (1) SE414174B (en)
SU (1) SU644385A3 (en)
YU (1) YU37331B (en)
ZA (2) ZA746665B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3578676A (en) * 1968-06-21 1971-05-11 Smith Kline French Lab Benzimidazole-2-carbamates substituted on the benzene ring with an acyloxyalkyl group
US3722322A (en) * 1971-05-05 1973-03-27 E Coeppert Speed control device
BE793358A (en) * 1971-12-27 1973-06-27 Hoechst Ag NEW 2-CARBALCOXY-AMINO-BENZIMIDAZOLE DERIVATIVES PRESENTING ANTHELMINTIC ACTIVITY AND THEIR PREPARATION PROCESS

Also Published As

Publication number Publication date
DK351774A (en) 1975-11-29
ATA556274A (en) 1976-11-15
DE2431093A1 (en) 1975-12-11
ES430794A1 (en) 1977-08-01
PL100057B1 (en) 1978-08-31
IT1046279B (en) 1980-06-30
SE414174B (en) 1980-07-14
CS222211B2 (en) 1983-05-27
ZA746665B (en) 1976-05-26
YU37331B (en) 1984-08-31
DK155005C (en) 1989-06-05
GB1480722A (en) 1977-07-20
DD115494A6 (en) 1975-10-05
SE7408108L (en) 1975-12-01
ZA746666B (en) 1976-06-30
JPS50155612A (en) 1975-12-16
DK155005B (en) 1989-01-23
AT337714B (en) 1977-07-11
BR7406197A (en) 1976-03-23
AR221575A1 (en) 1981-02-27
YU181374A (en) 1983-04-27
IE41199L (en) 1975-11-28
DE2431093C2 (en) 1982-12-02
SU644385A3 (en) 1979-01-25
RO64921A (en) 1979-07-15
CH614943A5 (en) 1979-12-28
BE817164Q (en) 1975-01-02
HU169779B (en) 1977-02-28

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