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IE37412L - Hypoglycaemic pyridine derivatives - Google Patents

Hypoglycaemic pyridine derivatives

Info

Publication number
IE37412L
IE37412L IE730426A IE42673A IE37412L IE 37412 L IE37412 L IE 37412L IE 730426 A IE730426 A IE 730426A IE 42673 A IE42673 A IE 42673A IE 37412 L IE37412 L IE 37412L
Authority
IE
Ireland
Prior art keywords
group
carboxylic acid
formula
alk
prepared
Prior art date
Application number
IE730426A
Other versions
IE37412B1 (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IE37412L publication Critical patent/IE37412L/en
Publication of IE37412B1 publication Critical patent/IE37412B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1437781 Pyridine derivatives BEECHAM GROUP Ltd 18 May 1973 [4 April 1972] 15280/72 Heading C2C [Also in Division A5] Compounds (mostly novel) of Formulµ I and II in which formulµ "Py" represents a substituted or unsubstituted 2-, 3- or 4-pyridyl group, or an N-oxidized or quaternized pyridyl group; "A" represents a group of Formula (IIIa), (IIIb) or (IIIc) wherein "ALK" represents a straight or branched chain alkylene group having from 1 to 6 carbon atoms; R 1 represents a carboxylic acid group or a group which is converted in the human body to a carboxylic acid group R 2 , R 3 and R 4 each separately represent hydrogen, a carboxylic acid group, a group which is converted in the human body to a carboxylic acid group, a hydroxy group, an alkoxy group, an aralkoxy group, an aryloxy group, an esterified hydroxy group, a nitro group, a halogen group or an amine group, are prepared by reacting a compound of formula B-(ALK) n OH with a compound of formula HO-(ALK) m -Py in which m and n are 0 or 1, provided n + m#0, and B is a group of Formula Ia or IIa The known compounds are those in which Py is 2-pyridyl or 5-ethylpyrid-2-yl, A is R 1 is methyl or methoxycarbonyl and R 2 , R 3 and R 4 are H or halogen. 2-Chloromethylpyridine is prepared by reacting 2-hydroxymethylpyridine with phosphorus oxychloride. p - Ethoxycarbonylbenzyl bromide is prepared by reacting ethyl p-toluate with N-bromosuccinimide. Pharmaceutical composition having hypoglycaemic activity, for oral administration, comprise a compound I or II together with a pharmaceutical carrier. [GB1437781A]
IE426/73A 1972-04-04 1973-03-15 Pyridine derivatives having hypoglycaemic activity IE37412B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1528072A GB1437781A (en) 1972-04-04 1972-04-04 Pyridine derivatives having hypoglycaemic activity

Publications (2)

Publication Number Publication Date
IE37412L true IE37412L (en) 1973-10-04
IE37412B1 IE37412B1 (en) 1977-07-20

Family

ID=10056262

Family Applications (1)

Application Number Title Priority Date Filing Date
IE426/73A IE37412B1 (en) 1972-04-04 1973-03-15 Pyridine derivatives having hypoglycaemic activity

Country Status (20)

Country Link
JP (1) JPS49100091A (en)
AR (1) AR208269A1 (en)
AT (1) AT339301B (en)
BE (1) BE797715A (en)
BG (1) BG20352A3 (en)
CA (1) CA999868A (en)
CH (1) CH576961A5 (en)
CS (1) CS183689B2 (en)
DD (1) DD106834A5 (en)
DE (1) DE2316881A1 (en)
ES (1) ES413279A1 (en)
FR (1) FR2182933B1 (en)
GB (1) GB1437781A (en)
HU (1) HU165731B (en)
IE (1) IE37412B1 (en)
IL (1) IL41825A (en)
NL (1) NL7304610A (en)
PL (1) PL96043B1 (en)
RO (2) RO63069A (en)
ZA (1) ZA731853B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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US4409227A (en) 1979-08-09 1983-10-11 The Dow Chemical Co. 4-(((Heterocyclo)thio)methyl)benzoic acids, esters and amides and their pharmaceutical use
EP0521549B1 (en) * 1991-07-03 1995-08-23 Unilever N.V. Chocolate fillings containing anti-bloom additive
ATE121271T1 (en) * 1991-07-03 1995-05-15 Unilever Nv IMPROVED CHOCOLATE COMPOSITION.
US5453433A (en) * 1994-05-13 1995-09-26 Sterling Winthrop Inc. Thiadiazoles and antipicornaviral compositions
US6043247A (en) * 1996-04-19 2000-03-28 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
JP2000509373A (en) * 1996-04-19 2000-07-25 ノボ ノルディスク アクティーゼルスカブ Modulators of molecules with phosphotyrosine recognition units
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
EP1056714B1 (en) 1998-02-26 2004-08-11 Celltech Therapeutics Limited Phenylalanine derivatives as inhibitors of alpha4 integrins
GB9805655D0 (en) 1998-03-16 1998-05-13 Celltech Therapeutics Ltd Chemical compounds
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
GB9811969D0 (en) * 1998-06-03 1998-07-29 Celltech Therapeutics Ltd Chemical compounds
GB9812088D0 (en) 1998-06-05 1998-08-05 Celltech Therapeutics Ltd Chemical compounds
GB9814414D0 (en) * 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
GB9821222D0 (en) 1998-09-30 1998-11-25 Celltech Therapeutics Ltd Chemical compounds
GB9825652D0 (en) 1998-11-23 1999-01-13 Celltech Therapeutics Ltd Chemical compounds
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
US6534513B1 (en) 1999-09-29 2003-03-18 Celltech R&D Limited Phenylalkanoic acid derivatives
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
EP1332132B1 (en) 2000-04-17 2007-10-10 UCB Pharma, S.A. Enamine derivatives as cell adhesion molecules
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
EP1301488A1 (en) 2000-07-07 2003-04-16 Celltech R&D Limited Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
JP2004505110A (en) 2000-08-02 2004-02-19 セルテック　アール　アンド　ディ　リミテッド 3-position substituted isoquinolin-1-yl derivative
HU230352B1 (en) * 2001-06-12 2016-02-29 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders and pharmaceutical compositions containing them
GB0405033D0 (en) * 2004-03-05 2004-04-07 Karobio Ab Novel pharmaceutical compositions
TWI490214B (en) * 2008-05-30 2015-07-01 艾德克 上野股份有限公司 Benzene or thiophene derivative and use thereof as vap-1 inhibitor
AR074760A1 (en) * 2008-12-18 2011-02-09 Metabolex Inc GPR120 RECEIVER AGONISTS AND USES OF THE SAME IN MEDICINES FOR THE TREATMENT OF DIABETES AND METABOLIC SYNDROME.
WO2015000900A2 (en) * 2013-07-01 2015-01-08 Givaudan Sa Organic compounds
WO2016167153A1 (en) * 2015-04-15 2016-10-20 長谷川香料株式会社 Flavor modulator having pyridine derivative or salt thereof as active ingredient
EP3440052B1 (en) * 2016-04-06 2023-10-25 University Of Oulu Compounds for use in the treatment of cancer

Also Published As

Publication number Publication date
CA999868A (en) 1976-11-16
ES413279A1 (en) 1976-01-01
IL41825A (en) 1977-03-31
HU165731B (en) 1974-10-28
JPS49100091A (en) 1974-09-20
BG20352A3 (en) 1975-11-05
FR2182933A1 (en) 1973-12-14
IL41825A0 (en) 1973-05-31
FR2182933B1 (en) 1976-05-14
RO63069A (en) 1978-08-15
CH576961A5 (en) 1976-06-30
ZA731853B (en) 1974-01-30
GB1437781A (en) 1976-06-03
DD106834A5 (en) 1974-07-05
CS183689B2 (en) 1978-07-31
ATA286773A (en) 1977-02-15
DE2316881A1 (en) 1973-10-11
IE37412B1 (en) 1977-07-20
AR208269A1 (en) 1976-12-20
PL96043B1 (en) 1977-11-30
NL7304610A (en) 1973-10-08
BE797715A (en) 1973-10-03
AT339301B (en) 1977-10-10
RO62274A (en) 1977-12-15

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