ID27589A - Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selular - Google Patents

Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selular

Info

Publication number: ID27589A
Authority: ID; Indonesia
Prior art keywords: bicyclic; pyyrimine; dihydropirymidine; proliferation; mobile
Prior art date: 1998-05-26

Application number

IDW20002452A

Other languages

English (en)

Inventor

Ellen Myra Dobrusin

James Marino Hamby

James Bernard Kramer

Mel Conrad Schroeder

Howard Daniel Hollis Showalter

Peter Toogood

Susanne A Trumpp Kallmeyer

Original Assignee

Warner Lambert Comapny

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-26

Filing date

1999-05-10

Publication date

2001-04-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26775058&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ID27589(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-05-10 Application filed by Warner Lambert Comapny filed Critical Warner Lambert Comapny

2001-04-12 Publication of ID27589A publication Critical patent/ID27589A/id

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

IDW20002452A 1998-05-26 1999-05-10 Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selular ID27589A (id)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8670898P	1998-05-26	1998-05-26
US12615899P	1999-03-25	1999-03-25

Publications (1)

Publication Number	Publication Date
ID27589A true ID27589A (id)	2001-04-12

Family

ID=26775058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDW20002452A ID27589A (id)	1998-05-26	1999-05-10	Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selular

Country Status (29)

Country	Link
US (1)	US7501425B1 (id)
EP (1)	EP1080092B1 (id)
JP (1)	JP2002516327A (id)
KR (1)	KR20010043829A (id)
CN (1)	CN1138778C (id)
AP (1)	AP2000001964A0 (id)
AT (1)	ATE402177T1 (id)
AU (1)	AU763839B2 (id)
BG (1)	BG104960A (id)
BR (1)	BR9911590A (id)
CA (1)	CA2329703C (id)
DE (1)	DE69939168D1 (id)
EA (1)	EA003640B1 (id)
EE (1)	EE200000706A (id)
ES (1)	ES2310039T3 (id)
GE (1)	GEP20033093B (id)
HK (1)	HK1039483A1 (id)
HR (1)	HRP20000799A2 (id)
HU (1)	HUP0102514A3 (id)
ID (1)	ID27589A (id)
IL (1)	IL139599A0 (id)
IS (1)	IS5687A (id)
NO (1)	NO20005928L (id)
NZ (1)	NZ508268A (id)
PL (1)	PL344248A1 (id)
SK (1)	SK17532000A3 (id)
TR (1)	TR200003429T2 (id)
WO (1)	WO1999061444A2 (id)
YU (1)	YU73300A (id)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TR200003429T2 (tr)	1998-05-26	2001-07-23	Warner-Lambert Company	Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler.
DE69920732T2 (de) *	1998-10-23	2006-02-23	F. Hoffmann-La Roche Ag	Bicyclische stickstoffheteroaryl verbindungen
MXPA02003950A (es) *	1999-10-21	2002-10-23	Hoffmann La Roche	Heterociclicos de nitrogeno biciclicos heteroalquilamino sustituidos como inhibidores de proteina cinasa p38.
IL149230A0 (en)	1999-10-21	2002-11-10	Hoffmann La Roche	Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase
KR20020067701A (ko) *	2000-01-24	2002-08-23	워너-램버트 캄파니	3-아미노퀴나졸린-2,4-디온 항균제
US7053070B2 (en)	2000-01-25	2006-05-30	Warner-Lambert Company	Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
BR0107751A (pt) *	2000-01-25	2002-11-12	Warner Lambert Co	Inibidores de pirido[2,3-d]pirimidina-2,7-diaminas quinase
MY141144A (en) *	2000-03-02	2010-03-15	Smithkline Beecham Corp	1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CN1422268A (zh) *	2000-03-06	2003-06-04	沃尼尔·朗伯公司	5－烷基吡啶并[2,3－d]嘧啶酪氨酸激酶抑制剂
MXPA03001821A (es) *	2000-08-31	2003-06-04	Hoffmann La Roche	7-oxo-piridopirimidinas como inhibidores de prolieferacion celular.
US6506749B2 (en)	2000-08-31	2003-01-14	Syntex (U.S.A.) Llc	7-oxo-pyridopyrimidines (I)
PL362049A1 (en)	2000-10-23	2004-10-18	Smithkline Beecham Corporation	Novel compounds
GB0029015D0 (en)	2000-11-28	2001-01-10	Univ London	Medical device
US7005434B2 (en)	2001-01-19	2006-02-28	Sb Corporation	Compounds and uses thereof
CN100376571C (zh)	2001-02-12	2008-03-26	霍夫曼-拉罗奇有限公司	6-取代的吡啶并嘧啶类化合物
US7105667B2 (en)	2001-05-01	2006-09-12	Bristol-Myers Squibb Co.	Fused heterocyclic compounds and use thereof
ATE315038T1 (de)	2001-05-30	2006-02-15	Warner Lambert Co	Antibakterielle mittel
ES2251677T3 (es) *	2002-01-22	2006-05-01	Warner-Lambert Company Llc	2-(piridin-2-ilamino)-pirido(2,3-d)pirimidin-7-onas.
US7176310B1 (en)	2002-04-09	2007-02-13	Ucb Sa	Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
KR20040103972A (ko)	2002-04-19	2004-12-09	스미스클라인 비참 코포레이션	신규 화합물
PA8577501A1 (es) *	2002-07-25	2004-02-07	Warner Lambert Co	Inhibidores de quinasas
MXPA05001332A (es)	2002-08-06	2005-04-28	Hoffmann La Roche	6-alcoxi-pirido-pirimidinas como inhibidores de cinasa del map p-38.
US7084270B2 (en) *	2002-08-14	2006-08-01	Hoffman-La Roche Inc.	Pyrimido compounds having antiproliferative activity
US7129351B2 (en) *	2002-11-04	2006-10-31	Hoffmann-La Roche Inc.	Pyrimido compounds having antiproliferative activity
TW200413381A (en) *	2002-11-04	2004-08-01	Hoffmann La Roche	Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
JP2006516561A (ja) *	2003-01-17	2006-07-06	ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー	細胞増殖の阻害剤としての２−アミノピリジン置換ヘテロ環類
CN100497339C (zh) *	2003-04-10	2009-06-10	霍夫曼-拉罗奇有限公司	嘧啶并化合物
DE10325133A1 (de) *	2003-06-04	2004-12-23	Bayer Cropscience Ag	Triazolopyrimidine
US7371750B2 (en)	2003-07-29	2008-05-13	Irm Llc	Compounds and compositions as protein kinase inhibitors
WO2005047284A1 (en)	2003-11-13	2005-05-26	F. Hoffmann-La Roche Ag	Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
JP4812763B2 (ja) *	2004-05-18	2011-11-09	ライジェルファーマシューティカルズ，インコーポレイテッド	シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途
US7494993B2 (en)	2004-08-31	2009-02-24	Hoffmann-La Roche Inc.	Amide derivatives of 7-amino-3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
WO2006024486A2 (en) *	2004-08-31	2006-03-09	F. Hoffmann-La Roche Ag	Amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
CA2590294A1 (en)	2004-12-13	2006-06-22	Sunesis Pharmaceuticals, Inc.	Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors
WO2006110298A2 (en)	2005-03-25	2006-10-19	Glaxo Group Limited	8-alkyl/aryl-4-aryl-2-n- (alkylamino)-n'-substituted-n'-cyanoguanidino-8h-pyrido[2,3-d]pyrimidin-7-one compounds and use thereof
AR053346A1 (es)	2005-03-25	2007-05-02	Glaxo Group Ltd	Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38
PE20061193A1 (es)	2005-03-25	2006-12-02	Glaxo Group Ltd	DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
US20080096905A1 (en)	2005-03-25	2008-04-24	Glaxo Group Limited	Process For Preparing Pyrido[2,3-D]Pyrimidin-7-One And 3,4-Dihydropyrimido{4,5-D}Pyrimidin-2(1H)-One Derivatives
BRPI0706781A2 (pt)	2006-01-31	2011-04-05	Hoffmann La Roche	7h-pirido[3,4-d]pirimidin-8-onas, sua fabricação e uso como inibidores da proteìna quinase
SI2168966T1 (sl)	2007-06-15	2017-03-31	Msd K.K.	Derivat biciklo anilina
MY150596A (en)	2008-02-01	2014-01-30	Takeda Pharmaceutical	Hsp90 inhibitors
AU2009325400A1 (en) *	2008-12-12	2010-06-17	Msd K.K.	Dihydropyrimidopyrimidine derivatives
AU2009325398A1 (en) *	2008-12-12	2010-06-17	Msd K.K.	Dihydropyrimidopyrimidine derivative
EP3255047B1 (en) *	2009-01-06	2021-06-30	Dana-Farber Cancer Institute, Inc.	Pyrimido-diazepinone kinase scaffold compounds and uses in treating disorders
WO2010098367A1 (en) *	2009-02-25	2010-09-02	Banyu Pharmaceutical Co.,Ltd.	Pyrimidopyrimidoindazole derivative
SA111320200B1 (ar) *	2010-02-17	2014-02-16	ديبيوفارم اس ايه	مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة
ES2525866T3 (es) *	2010-08-05	2014-12-30	Temple University - Of The Commonwealth System Of Higher Education	8-alquil-7-oxo-7,8-dihidropirido [2,3-d]pirimidina-6-carbonitrilos sustituidos en 2 y usos de los mismos
WO2012088266A2 (en)	2010-12-22	2012-06-28	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
CN111499580A (zh)	2011-04-22	2020-08-07	西格诺药品有限公司	取代的二氨基甲酰胺和二氨基甲腈嘧啶，其组合物，和用其治疗的方法
LT2766346T (lt)	2011-10-14	2017-06-12	Bristol-Myers Squibb Company	Pakeistieji tetrahidroizochinolino junginiai, kaip faktoriaus xia inhibitoriai
JP6033318B2 (ja)	2011-10-14	2016-11-30	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	第ＸＩａ因子阻害剤としての置換テトラヒドロイソキノリン化合物
IN2014CN02806A (id)	2011-10-14	2015-07-03	Bristol Myers Squibb Co
HUE031916T2 (en) *	2012-06-13	2017-08-28	Incyte Holdings Corp	Substituted tricyclic compounds as FGFR inhibitors
RU2019102203A (ru) *	2012-07-11	2019-03-05	Блюпринт Медсинс Корпорейшн	Ингибиторы рецептора фактора роста фибробластов
US9388185B2 (en)	2012-08-10	2016-07-12	Incyte Holdings Corporation	Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
EP2906552B1 (en)	2012-10-12	2017-11-22	Bristol-Myers Squibb Company	Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
PE20150639A1 (es)	2012-10-12	2015-05-11	Bristol Myers Squibb Co	Formas cristalinas de inhibidor del factor xia
WO2014059214A1 (en)	2012-10-12	2014-04-17	Bristol-Myers Squibb Company	Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
EP3943087A1 (en)	2013-03-15	2022-01-26	Celgene CAR LLC	Heteroaryl compounds and uses thereof
BR112015022191A8 (pt)	2013-03-15	2018-01-23	Celgene Avilomics Res Inc	compostos heteroarila e usos dos mesmos
AR095464A1 (es)	2013-03-15	2015-10-21	Celgene Avilomics Res Inc	Compuestos de heteroarilo y usos de los mismos
JP6479763B2 (ja)	2013-03-25	2019-03-06	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン
PL2986610T4 (pl) *	2013-04-19	2019-06-28	Incyte Holdings Corporation	Bicykliczne heterocykle jako inhibitory FGFR
EP3019491A4 (en)	2013-07-09	2016-12-21	Dana Farber Cancer Inst Inc	KINASE INHIBITORS FOR THE TREATMENT OF DISEASE
MX2016004933A (es)	2013-10-18	2016-12-20	Eisai R&D Man Co Ltd	Inhibidores de pirimidina del fgfr4.
SMT202200292T1 (it)	2013-10-25	2022-09-14	Blueprint Medicines Corp	Inibitori del recettore del fattore di crescita dei fibroblasti
CA2934061A1 (en)	2013-12-20	2015-06-25	Signal Pharmaceuticals, Llc	Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith
NO2760821T3 (id)	2014-01-31	2018-03-10
TWI688564B (zh)	2014-01-31	2020-03-21	美商必治妥美雅史谷比公司	作為凝血因子ｘｉａ抑制劑之具有雜環p2'基團之巨環化合物
CN103880861B (zh) *	2014-02-21	2016-02-03	温州医科大学	一种作用于FGF受体的4,6-二甲基-噁唑并[5,4-d]嘧啶-5,7（4H,6H）-二酮衍生物
JP6526796B2 (ja)	2014-09-04	2019-06-05	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｆｘｉａ阻害剤であるジアミドマクロ環
US9453018B2 (en)	2014-10-01	2016-09-27	Bristol-Myers Squibb Company	Pyrimidinones as factor XIa inhibitors
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
EP3259269B9 (en)	2015-02-20	2020-03-04	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
WO2016134294A1 (en)	2015-02-20	2016-08-25	Incyte Corporation	Bicyclic heterocycles as fgfr4 inhibitors
CN107660200B (zh)	2015-04-14	2022-01-11	卫材R&D管理有限公司	结晶fgfr4抑制剂化合物和其用途
JP7372740B2 (ja)	2016-05-10	2023-11-01	エーザイ・アール・アンド・ディー・マネジメント株式会社	細胞生存性及び／又は細胞増殖を低減するための薬物の組み合わせ
CN107459519A (zh) *	2016-06-06	2017-12-12	上海艾力斯医药科技有限公司	稠合嘧啶哌啶环衍生物及其制备方法和应用
JP7277357B2 (ja) *	2016-07-05	2023-05-18	ザブロードインスティテュート，インコーポレーテッド	二環式尿素キナーゼインヒビターおよびそれらの使用
TWI808958B (zh)	2017-01-25	2023-07-21	美商特普醫葯公司	涉及二芳基巨環化合物之組合療法
BR112019017741A2 (pt)	2017-02-28	2020-04-07	Dana Farber Cancer Inst Inc	usos de pirimidopirimidinonas como inibidores de sik
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
ES2991427T3 (es)	2018-05-04	2024-12-03	Incyte Corp	Formas sólidas de un inhibidor de FGFR y procedimientos para preparar las mismas
CA3099116A1 (en)	2018-05-04	2019-11-07	Incyte Corporation	Salts of an fgfr inhibitor
US11628162B2 (en)	2019-03-08	2023-04-18	Incyte Corporation	Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en)	2019-07-09	2021-01-14	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
US12122767B2 (en)	2019-10-01	2024-10-22	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
EP4045151A1 (en)	2019-10-14	2022-08-24	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
WO2021076728A1 (en)	2019-10-16	2021-04-22	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
PE20221504A1 (es)	2019-12-04	2022-09-30	Incyte Corp	Derivados de un inhibidor de fgfr
CA3163875A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en)	2020-01-15	2024-06-18	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
US11691971B2 (en)	2020-06-19	2023-07-04	Incyte Corporation	Naphthyridinone compounds as JAK2 V617F inhibitors
US11753413B2 (en)	2020-06-19	2023-09-12	Incyte Corporation	Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
MX2023000056A (es)	2020-07-02	2023-04-12	Incyte Corp	Compuestos tricíclicos de urea como inhibidores de la variante v617f de la cinasa de janus 2 (jak2 v617f).
US11767323B2 (en)	2020-07-02	2023-09-26	Incyte Corporation	Tricyclic pyridone compounds as JAK2 V617F inhibitors
WO2022046989A1 (en)	2020-08-27	2022-03-03	Incyte Corporation	Tricyclic urea compounds as jak2 v617f inhibitors
WO2022140231A1 (en)	2020-12-21	2022-06-30	Incyte Corporation	Deazaguaine compounds as jak2 v617f inhibitors
TW202302589A (zh)	2021-02-25	2023-01-16	美商英塞特公司	作為ｊａｋ２ｖ６１７ｆ抑制劑之螺環內醯胺
WO2022221170A1 (en)	2021-04-12	2022-10-20	Incyte Corporation	Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
WO2022261160A1 (en)	2021-06-09	2022-12-15	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
CN119173514A (zh)	2022-03-17	2024-12-20	因赛特公司	作为jak2 v617f抑制剂的三环脲化合物
WO2024199388A1 (zh) *	2023-03-29	2024-10-03	微境生物医药科技(上海)有限公司	作为myt1抑制剂的化合物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2949466A (en)	1958-03-04	1960-08-16	Parke Davis & Co	Pyrimidine compounds and means of producing the same
ES338687A1 (es)	1966-04-06	1968-04-01	Monsanto Co	Procedimiento para obtener composiciones de fluidos funcio-nales.
US3912723A (en)	1971-03-29	1975-10-14	Pfizer	2-Phenyl-as-triazine-3,5(2H,4H)diones
IT1146940B (it) *	1979-06-14	1986-11-19	Wellcome Found	Composti 2,4-diamminopirido (2,3-d) pirimidinici dotati di attivita' farmacologica e procedimento per la loro preparazione
US4425346A (en)	1980-08-01	1984-01-10	Smith And Nephew Associated Companies Limited	Pharmaceutical compositions
JPS60226882A (ja)	1984-04-24	1985-11-12	Nippon Zoki Pharmaceut Co Ltd	新規ピリミドピリミジン誘導体
EP0278686A1 (en)	1987-02-07	1988-08-17	The Wellcome Foundation Limited	Pyridopyrimidines methods for their preparation and pharmaceutical formulations thereof
DK0584222T3 (da) *	1991-05-10	1998-02-23	Rhone Poulenc Rorer Int	Bis-mono- og bicycliske aryl- og heteroarylforbindelser, som inhiberer EGF- og/eller PDGF-receptor-tyrosinkinase
IL112249A (en)	1994-01-25	2001-11-25	Warner Lambert Co	Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5679683A (en)	1994-01-25	1997-10-21	Warner-Lambert Company	Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
AU701127B2 (en)	1994-10-27	1999-01-21	Merck & Co., Inc.	Muscarine antagonists
DE69515898T2 (de)	1994-11-14	2000-08-17	Warner-Lambert Co., Morris Plains	6-ARYL-PYRIDO[2,3-d]PYRIMIDINE UND -NAPHTHYRIDINE ZUR HEMMUNG DER DURCH PROTEIN-TYROSIN-KINASE HERVORGERUFENEN ZELLVERMEHRUNG
IL117923A (en)	1995-05-03	2000-06-01	Warner Lambert Co	Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
JP3370340B2 (ja) *	1996-04-12	2003-01-27	ワーナー―ランバート・コンパニー	チロシンキナーゼの不可逆的阻害剤
CA2271157A1 (en)	1997-02-05	1998-08-06	Warner-Lambert Company	Pyrido[2,3-d]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation
ZA986732B (en)	1997-07-29	1999-02-02	Warner Lambert Co	Irreversible inhibitiors of tyrosine kinases
AU742999B2 (en) *	1997-08-20	2002-01-17	Warner-Lambert Company	Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation
JP4038624B2 (ja)	1997-11-29	2008-01-30	日本農薬株式会社	縮合複素環誘導体及びその中間体並びに有害生物防除剤
TR200003429T2 (tr)	1998-05-26	2001-07-23	Warner-Lambert Company	Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler.
DE69920732T2 (de)	1998-10-23	2006-02-23	F. Hoffmann-La Roche Ag	Bicyclische stickstoffheteroaryl verbindungen
MXPA02003950A (es)	1999-10-21	2002-10-23	Hoffmann La Roche	Heterociclicos de nitrogeno biciclicos heteroalquilamino sustituidos como inhibidores de proteina cinasa p38.
IL149230A0 (en)	1999-10-21	2002-11-10	Hoffmann La Roche	Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase
MY141144A (en)	2000-03-02	2010-03-15	Smithkline Beecham Corp	1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases

1999
- 1999-05-10 TR TR2000/03429T patent/TR200003429T2/xx unknown
- 1999-05-10 EE EEP200000706A patent/EE200000706A/xx unknown
- 1999-05-10 NZ NZ508268A patent/NZ508268A/xx unknown
- 1999-05-10 SK SK1753-2000A patent/SK17532000A3/sk unknown
- 1999-05-10 IL IL13959999A patent/IL139599A0/xx unknown
- 1999-05-10 YU YU73300A patent/YU73300A/sh unknown
- 1999-05-10 PL PL99344248A patent/PL344248A1/xx not_active Application Discontinuation
- 1999-05-10 ES ES99924165T patent/ES2310039T3/es not_active Expired - Lifetime
- 1999-05-10 CA CA002329703A patent/CA2329703C/en not_active Expired - Fee Related
- 1999-05-10 HU HU0102514A patent/HUP0102514A3/hu unknown
- 1999-05-10 AU AU40734/99A patent/AU763839B2/en not_active Ceased
- 1999-05-10 KR KR1020007013279A patent/KR20010043829A/ko not_active Application Discontinuation
- 1999-05-10 AP APAP/P/2000/001964A patent/AP2000001964A0/en unknown
- 1999-05-10 DE DE69939168T patent/DE69939168D1/de not_active Expired - Fee Related
- 1999-05-10 WO PCT/US1999/010187 patent/WO1999061444A2/en not_active Application Discontinuation
- 1999-05-10 BR BR9911590-5A patent/BR9911590A/pt not_active Application Discontinuation
- 1999-05-10 ID IDW20002452A patent/ID27589A/id unknown
- 1999-05-10 EA EA200001171A patent/EA003640B1/ru not_active IP Right Cessation
- 1999-05-10 CN CNB998065587A patent/CN1138778C/zh not_active Expired - Fee Related
- 1999-05-10 JP JP2000550849A patent/JP2002516327A/ja not_active Abandoned
- 1999-05-10 GE GEAP19995700A patent/GEP20033093B/en unknown
- 1999-05-10 US US09/623,737 patent/US7501425B1/en not_active Expired - Fee Related
- 1999-05-10 EP EP99924165A patent/EP1080092B1/en not_active Expired - Lifetime
- 1999-05-10 AT AT99924165T patent/ATE402177T1/de not_active IP Right Cessation
2000
- 2000-10-27 IS IS5687A patent/IS5687A/is unknown
- 2000-11-17 BG BG104960A patent/BG104960A/xx unknown
- 2000-11-20 HR HR20000799A patent/HRP20000799A2/hr not_active Application Discontinuation
- 2000-11-23 NO NO20005928A patent/NO20005928L/no not_active Application Discontinuation
2001
- 2001-11-08 HK HK01107828A patent/HK1039483A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1080092A2 (en)	2001-03-07
EP1080092B1 (en)	2008-07-23
NO20005928D0 (no)	2000-11-23
BG104960A (en)	2001-10-31
KR20010043829A (ko)	2001-05-25
ATE402177T1 (de)	2008-08-15
WO1999061444A2 (en)	1999-12-02
ES2310039T3 (es)	2008-12-16
AP2000001964A0 (en)	2000-12-31
DE69939168D1 (de)	2008-09-04
EA003640B1 (ru)	2003-08-28
CA2329703A1 (en)	1999-12-02
US7501425B1 (en)	2009-03-10
GEP20033093B (en)	2003-10-27
HUP0102514A3 (en)	2002-03-28
HRP20000799A2 (en)	2001-06-30
HK1039483A1 (en)	2002-04-26
CA2329703C (en)	2005-12-20
EA200001171A1 (ru)	2001-06-25
SK17532000A3 (sk)	2002-08-06
HUP0102514A2 (hu)	2001-11-28
BR9911590A (pt)	2001-02-13
NZ508268A (en)	2004-02-27
AU763839B2 (en)	2003-07-31
EE200000706A (et)	2002-06-17
TR200003429T2 (tr)	2001-07-23
IL139599A0 (en)	2002-02-10
JP2002516327A (ja)	2002-06-04
WO1999061444A3 (en)	2000-02-03
PL344248A1 (en)	2001-10-22
CN1302301A (zh)	2001-07-04
IS5687A (is)	2000-10-27
AU4073499A (en)	1999-12-13
NO20005928L (no)	2000-11-23
YU73300A (sh)	2003-08-29
CN1138778C (zh)	2004-02-18

Publication	Publication Date	Title
ID27589A (id)	2001-04-12	Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selular
DE69730944D1 (de)	2004-11-04	Adaptive überprüfung der anwesenheit von mobilen stationen
DE69838561D1 (de)	2007-11-22	Funkgerät
ID18354A (id)	1998-04-02	Metoda dan susunan untuk komunikasi radio
FI972461A (fi)	1998-12-11	Radiojärjestelmä
ID29591A (id)	2001-09-06	Senyawa-senyawa kuinolina dan kuinoksalina
ID23575A (id)	2000-05-04	Pirazolopirimidina-pirazolopirimidina dan pirazolotriazina-pirazolotriazina
DE69836882D1 (de)	2007-03-08	Funkgerät
ID18046A (id)	1998-02-19	Senyawa siklik campuran, pembuatan dan penngunaannya.
ID19824A (id)	1998-08-06	Turunan-turunan ditiolan, pembuatannya dan pengaruh terapinya
ID19422A (id)	1998-07-09	Piridina dan bifenil tersubstitusi
NO20001405D0 (no)	2000-03-17	Modifisert alumoksan-katalysatoraktivator
DE69731030D1 (de)	2004-11-11	Funksendeempfänger
DE69833161D1 (de)	2006-04-06	Funkgerät
FI974646A0 (fi)	1997-12-30	Utjaemning av stoerningar i mobilkommunicationssystem
NO20000014D0 (no)	2000-01-03	Grohemmende polymerer
ID16889A (id)	1997-11-20	Senyawa turunan alkilaminobenzotiazol dan benzoksazol
ID18456A (id)	1998-04-09	Produksi-bersama 6-aminokapronitril dan heksametilenadiamina
FI973869A (fi)	1999-04-03	Matkaviestin
ID23258A (id)	2000-04-05	Penarik pemberian-menyilang dan metodenya
ID16587A (id)	1997-10-16	Koproduksi 6-aminokapronitril dan heksametilendiamin
ID18459A (id)	1998-04-09	Produksi-bersama 6-aminokapronitril dan heksametilenadiamina
DE59814027D1 (de)	2007-07-26	Funkgerät
NO993662D0 (no)	1999-07-28	Polymerer
DE59813009D1 (de)	2005-09-22	Funkgerät