ID27586A - Komposisi aerosol - Google Patents
Komposisi aerosolInfo
- Publication number
- ID27586A ID27586A IDW20002207A ID20002207A ID27586A ID 27586 A ID27586 A ID 27586A ID W20002207 A IDW20002207 A ID W20002207A ID 20002207 A ID20002207 A ID 20002207A ID 27586 A ID27586 A ID 27586A
- Authority
- ID
- Indonesia
- Prior art keywords
- particulate material
- aerosol composition
- mum
- propellant
- particles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9807232.5A GB9807232D0 (en) | 1998-04-03 | 1998-04-03 | Aerosol composition |
Publications (1)
Publication Number | Publication Date |
---|---|
ID27586A true ID27586A (id) | 2001-04-12 |
Family
ID=10829846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW20002207A ID27586A (id) | 1998-04-03 | 1999-04-01 | Komposisi aerosol |
Country Status (17)
Country | Link |
---|---|
US (2) | US6737044B1 (zh) |
EP (1) | EP1069887B8 (zh) |
JP (1) | JP2002510614A (zh) |
KR (1) | KR20010072563A (zh) |
CN (1) | CN1215832C (zh) |
AT (1) | ATE474555T1 (zh) |
AU (1) | AU761518B2 (zh) |
BR (1) | BR9909394A (zh) |
CA (1) | CA2327336C (zh) |
DE (1) | DE69942606D1 (zh) |
ES (1) | ES2349184T3 (zh) |
GB (1) | GB9807232D0 (zh) |
ID (1) | ID27586A (zh) |
IL (1) | IL138770A0 (zh) |
MX (1) | MXPA00009660A (zh) |
WO (1) | WO1999051205A1 (zh) |
ZA (1) | ZA200005374B (zh) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9807232D0 (en) | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
DE19921693A1 (de) | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
GB9928311D0 (en) * | 1999-11-30 | 2000-01-26 | Novartis Ag | Organic compounds |
AU2001258585B2 (en) * | 2000-05-23 | 2006-12-21 | Glaxo Group Limited | Aerosol container for formulations of salmeterol xinafoate |
GB0015043D0 (en) * | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
US20040081627A1 (en) * | 2000-10-09 | 2004-04-29 | Jinks Phillip A | Medicinal aerosol formulations |
HU229899B1 (en) * | 2000-12-22 | 2014-12-29 | Glaxo Group Ltd Brentford | Metered dose inhaler for salmeterol xinafoate |
DE60221640T2 (de) * | 2001-02-06 | 2008-05-21 | Innovata Biomed Ltd., St. Albans | Bimodale trockenpulverzusammensetzung zur inhalation |
WO2002080859A2 (en) * | 2001-03-20 | 2002-10-17 | Glaxo Group Limited | Inhalation drug combinations |
JP2005507881A (ja) * | 2001-09-17 | 2005-03-24 | グラクソ グループ リミテッド | 乾燥粉末医薬製剤 |
EP1487407A4 (en) * | 2002-03-12 | 2010-08-25 | Microdose Therapeutx Inc | SITE SPECIFICITY ADMINISTRATION OF MEDICAMENTS SIMULTANEOUSLY TAKEN BY INHALATION |
US20050158248A1 (en) * | 2002-08-21 | 2005-07-21 | Xian-Ming Zeng | Method of preparing dry powder inhalation compositions |
GB0219511D0 (en) | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Method of preparing dry powder inhalation compositions |
GB0219512D0 (en) * | 2002-08-21 | 2002-10-02 | Norton Healthcare Ltd | Inhalation compositions with high drug ratios |
MXPA05001903A (es) * | 2002-08-21 | 2005-04-28 | Norton Healthcare Ltd | Composicion para inhalacion. |
CA2496882C (en) * | 2002-09-06 | 2011-11-01 | 3M Innovative Properties Company | Metering valve for a metered dose inhaler providing consistent delivery |
US7497214B2 (en) * | 2002-09-16 | 2009-03-03 | 3M Innovative Properties Company | Aerosol dispensers and adaptors therefor |
GB0221343D0 (en) * | 2002-09-16 | 2002-10-23 | 3M Innovative Properties Co | Aerosol dispensers and adaptors therefor |
US7638138B2 (en) | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
CN1758930B (zh) | 2003-03-27 | 2010-06-09 | 株式会社新日本科学 | 鼻腔用粉末药剂喷药装置 |
EP1641682B1 (en) * | 2003-06-24 | 2011-01-05 | Cipla Limited | Pharmaceutical dispensing aid |
WO2005051511A1 (ja) * | 2003-11-28 | 2005-06-09 | Mitsubishi Chemical Corporation | 有機化合物微粒子の製造方法 |
DE102004011381A1 (de) * | 2004-03-05 | 2005-09-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Impaktionsdüse für treibgasbetriebene Dosieraerosole |
JP2007537833A (ja) * | 2004-05-20 | 2007-12-27 | ディスカバリー ラボラトリーズ,インコーポレイテッド | 非侵襲的な肺吸入のための方法、システム、及び装置 |
GB0501956D0 (en) * | 2005-01-31 | 2005-03-09 | Arrow Internat | Nebulizer formulation |
US8028697B2 (en) | 2005-04-28 | 2011-10-04 | Trudell Medical International | Ventilator circuit and method for the use thereof |
US20060260606A1 (en) * | 2005-05-18 | 2006-11-23 | Coifman Robert E | Inhalable formulations of amphotericin B and methods and devices for delivery thereof |
US8367734B1 (en) | 2005-08-11 | 2013-02-05 | Amphastar Pharmaceuticals Inc. | Stable epinephrine suspension formulation with high inhalation delivery efficiency |
DE102006014433A1 (de) * | 2006-03-27 | 2007-10-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dosieraerosole für die Verabreichung von pharmazeutischen Zubereitungen |
US20080269347A1 (en) * | 2006-09-28 | 2008-10-30 | Azopharma, Inc. | Epinephrine formulations |
US8337817B2 (en) | 2006-12-26 | 2012-12-25 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
US20080202627A1 (en) * | 2007-02-23 | 2008-08-28 | Mas Gregory V | Dosing System and Method |
PT2230934E (pt) | 2007-12-14 | 2012-11-20 | Aerodesigns Inc | Distribuir produtos alimentares aerossolizáveis |
EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2265309B1 (en) | 2008-03-17 | 2015-12-16 | Discovery Laboratories, Inc. | Ventilation circuit adaptor and proximal aerosol delivery system |
EP2179760B1 (en) | 2008-10-22 | 2013-02-27 | Trudell Medical International | Modular Aerosol Delivery System |
US20120064126A1 (en) | 2009-03-26 | 2012-03-15 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
EP2429495A4 (en) | 2009-05-15 | 2014-01-22 | Shin Nippon Biomedical Lab Ltd | INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS |
WO2011013003A2 (en) | 2009-07-31 | 2011-02-03 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
WO2011066107A1 (en) | 2009-11-24 | 2011-06-03 | Gilead Sciences, Inc. | Inhaled fosfomycin/tobramycin for the treatment of chronic obstructive pulmonary disease |
WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
CN102665807A (zh) | 2010-01-05 | 2012-09-12 | 微剂量治疗技术公司 | 吸入设备和方法 |
UY33373A (es) | 2010-05-10 | 2011-12-30 | Gilead Sciences Inc | ?Compuestos de pirazolopiridina bifuncionales, su uso en terapia y composiciones que los comprenden?. |
UY33372A (es) | 2010-05-10 | 2011-12-30 | Gilead Sciences Inc | ?análogos de quinolina bi?funcionales, su uso en la manufactura de medicamentos,composiciones que los comprenden y procesos de preparacion?. |
CA2809666C (en) | 2010-08-30 | 2020-09-22 | Michael M. Lipp | Dry powder formulations and methods for treating pulmonary diseases |
EP2448571B1 (en) | 2010-08-30 | 2013-06-12 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
CN102416179B (zh) | 2010-09-28 | 2014-05-07 | 益得生物科技股份有限公司 | 用于哮喘的吸入性复方组合物 |
CN107096014B (zh) | 2010-09-29 | 2022-07-15 | 普马特里克斯营业公司 | 吸入用单价金属阳离子干粉剂 |
EP3470057B1 (en) | 2010-09-29 | 2021-11-03 | Pulmatrix Operating Company, Inc. | Cationic dry powders comprising magnesium salt |
FR2971772B1 (fr) * | 2011-02-17 | 2013-03-22 | Valois Sas | Dispositif de distribution de produit fluide. |
TWI399202B (zh) | 2011-03-17 | 2013-06-21 | Intech Biopharm Ltd | 製備用於治療呼吸道疾病之定量噴霧吸入劑的製程方法 |
FR2973786B1 (fr) * | 2011-04-06 | 2014-07-04 | Valois Sas | Bague pour dispositif de distribution de produit fluide. |
EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
WO2013181232A2 (en) | 2012-05-29 | 2013-12-05 | Michael Ross Johnson | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases |
ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
BR112015014178A2 (pt) | 2012-12-17 | 2017-07-11 | Parion Sciences Inc | compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida |
WO2014099676A1 (en) | 2012-12-17 | 2014-06-26 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
CN105473133A (zh) | 2013-04-30 | 2016-04-06 | 欧缇托匹克公司 | 干粉制剂及使用方法 |
PT3104853T (pt) | 2014-02-10 | 2020-01-14 | Respivant Sciences Gmbh | Tratamento com estabilizadores de mastócitos para distúrbios sistémicos |
EP3104854B1 (en) | 2014-02-10 | 2020-04-08 | Respivant Sciences GmbH | Mast cell stabilizers for lung disease treatment |
GB201402513D0 (en) | 2014-02-13 | 2014-04-02 | Cardiff Scintigraphics Ltd | Pressurised metered dose inhalers and method of manufacture |
ES2922206T3 (es) | 2014-02-20 | 2022-09-09 | Otitopic Inc | Formulaciones de polvo seco para la inhalación |
PL3179986T3 (pl) | 2014-07-31 | 2023-06-26 | Vectura Inc. | Suche formulacje w proszku do inhalacji |
EP3331522A1 (en) | 2015-08-07 | 2018-06-13 | Patara Pharma LLC | Methods for the treatment of mast cell related disorders with mast cell stabilizers |
WO2017027402A1 (en) | 2015-08-07 | 2017-02-16 | Patara Pharma, LLC | Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders |
CA3035528A1 (en) | 2016-08-31 | 2018-03-08 | Respivant Sciences Gmbh | Cromolyn compositions for treatment of chronic cough due to idiopathic pulmonary fibrosis |
CN109803724A (zh) | 2016-10-07 | 2019-05-24 | 瑞思皮万特科学有限责任公司 | 用于治疗肺纤维化的色甘酸组合物 |
CN107529499B (zh) * | 2017-04-20 | 2020-06-09 | 苏州康乐辉医药科技有限公司 | 一种气雾剂药液浓度稳定装置 |
US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
CN118695855A (zh) * | 2022-01-21 | 2024-09-24 | 香港大学 | 通过单次鼻内施用用于鼻和肺沉积的抗病毒剂的双重靶向粉末制剂 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3046863A1 (de) | 1980-12-12 | 1982-07-22 | Robert Bosch Gmbh, 7000 Stuttgart | Elektronisch gesteuertes kraftstoffzumesssystem fuer eine brennkraftmaschine |
GB8613811D0 (en) * | 1986-06-06 | 1986-07-09 | Phares Pharm Res Nv | Composition & method |
GB8828477D0 (en) | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
AU5194990A (en) * | 1989-02-23 | 1990-09-26 | Rorer International (Holdings), Inc. | Therapeutic aerosol formulations |
CH680263A5 (zh) | 1989-07-20 | 1992-07-31 | Norman Godin | |
HUT63554A (en) | 1990-06-29 | 1993-09-28 | Fisons Plc | Aerosol preparations under pressure |
ES2064160T3 (es) | 1990-10-18 | 1995-01-16 | Minnesota Mining & Mfg | Formulacion de aerosol que comprende 17,21-dipropionato de beclometasona. |
GB9024366D0 (en) | 1990-11-09 | 1991-01-02 | Glaxo Group Ltd | Medicaments |
EP0504112A3 (en) | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
EP0561166A1 (de) | 1992-03-17 | 1993-09-22 | ASTA Medica Aktiengesellschaft | Dosieraerosole enthaltend den Wirkstoff D-18024 und verwandte Strukturen |
US5626871A (en) * | 1992-06-12 | 1997-05-06 | Teijin Limited | Preparation for intratracheobronchial administration |
KR100321649B1 (ko) * | 1993-03-17 | 2002-07-22 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | 에스테르,아미드또는머캅토에스테르로부터유도된분산보조제를함유하는에어로졸제제 |
GB9404945D0 (en) | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
GB9419269D0 (en) * | 1994-09-23 | 1994-11-09 | Unilever Plc | Aerosol |
GB9426252D0 (en) * | 1994-12-24 | 1995-02-22 | Glaxo Group Ltd | Pharmaceutical composition |
GB2307842A (en) | 1995-12-05 | 1997-06-11 | Lin Chan Yen | Ventilated protective helmet |
RU2101054C1 (ru) | 1996-04-30 | 1998-01-10 | Закрытое акционерное общество "Техно-ТМ" | Аэрозолеобразующий состав для тушения пожаров и способ его получения |
GB9619968D0 (en) | 1996-09-25 | 1996-11-13 | Johnson & Johnson Professional | Hinge with locking means |
SK13632000A3 (sk) * | 1998-03-16 | 2001-03-12 | Inhale Therapeutic Systems, Inc. | Spôsob podávania aktívnej látky do pľúc ľudského pacienta a zariadenie na jeho vykonávanie |
GB9807232D0 (en) | 1998-04-03 | 1998-06-03 | Univ Cardiff | Aerosol composition |
US6136294C1 (en) | 1998-09-22 | 2002-09-24 | Aeropharm Technology Inc | Amino acid stabilized medical aerosol formulation |
-
1998
- 1998-04-03 GB GBGB9807232.5A patent/GB9807232D0/en not_active Ceased
-
1999
- 1999-04-01 BR BR9909394-4A patent/BR9909394A/pt not_active Application Discontinuation
- 1999-04-01 IL IL13877099A patent/IL138770A0/xx unknown
- 1999-04-01 WO PCT/GB1999/001019 patent/WO1999051205A1/en not_active Application Discontinuation
- 1999-04-01 CN CN998067121A patent/CN1215832C/zh not_active Expired - Fee Related
- 1999-04-01 ES ES99913508T patent/ES2349184T3/es not_active Expired - Lifetime
- 1999-04-01 JP JP2000541977A patent/JP2002510614A/ja active Pending
- 1999-04-01 DE DE69942606T patent/DE69942606D1/de not_active Expired - Lifetime
- 1999-04-01 ID IDW20002207A patent/ID27586A/id unknown
- 1999-04-01 MX MXPA00009660A patent/MXPA00009660A/es active IP Right Grant
- 1999-04-01 AT AT99913508T patent/ATE474555T1/de not_active IP Right Cessation
- 1999-04-01 CA CA002327336A patent/CA2327336C/en not_active Expired - Fee Related
- 1999-04-01 KR KR1020007011018A patent/KR20010072563A/ko not_active Application Discontinuation
- 1999-04-01 US US09/647,331 patent/US6737044B1/en not_active Expired - Lifetime
- 1999-04-01 AU AU31620/99A patent/AU761518B2/en not_active Ceased
- 1999-04-01 EP EP99913508A patent/EP1069887B8/en not_active Expired - Lifetime
-
2000
- 2000-10-03 ZA ZA200005374A patent/ZA200005374B/en unknown
-
2003
- 2003-09-23 US US10/668,840 patent/US7481995B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL138770A0 (en) | 2001-10-31 |
CN1303270A (zh) | 2001-07-11 |
JP2002510614A (ja) | 2002-04-09 |
DE69942606D1 (de) | 2010-09-02 |
US7481995B2 (en) | 2009-01-27 |
US20050249674A1 (en) | 2005-11-10 |
EP1069887A1 (en) | 2001-01-24 |
CN1215832C (zh) | 2005-08-24 |
MXPA00009660A (es) | 2003-07-14 |
EP1069887B1 (en) | 2010-07-21 |
EP1069887B8 (en) | 2010-08-25 |
ES2349184T3 (es) | 2010-12-28 |
ATE474555T1 (de) | 2010-08-15 |
AU3162099A (en) | 1999-10-25 |
AU761518B2 (en) | 2003-06-05 |
WO1999051205A1 (en) | 1999-10-14 |
BR9909394A (pt) | 2000-12-05 |
CA2327336A1 (en) | 1999-10-14 |
CA2327336C (en) | 2008-07-08 |
KR20010072563A (ko) | 2001-07-31 |
ZA200005374B (en) | 2002-01-03 |
US6737044B1 (en) | 2004-05-18 |
GB9807232D0 (en) | 1998-06-03 |
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