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HUT38892A - Process for preparing alpha-, omega-dicarboxylic acids and pharmaceutical compositions comprising the same as active substance - Google Patents

Process for preparing alpha-, omega-dicarboxylic acids and pharmaceutical compositions comprising the same as active substance

Info

Publication number
HUT38892A
HUT38892A HU853002A HU300285A HUT38892A HU T38892 A HUT38892 A HU T38892A HU 853002 A HU853002 A HU 853002A HU 300285 A HU300285 A HU 300285A HU T38892 A HUT38892 A HU T38892A
Authority
HU
Hungary
Prior art keywords
omega
pharmaceutical compositions
same
active substance
dicarboxylic acids
Prior art date
Application number
HU853002A
Other languages
English (en)
Inventor
Jacob Bar-Tana
Ernst-Christian Witte
Bernd Hagenbruch
Johannes Pill
Karlheinz Stegmeier
Original Assignee
Epis Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epis Sa filed Critical Epis Sa
Publication of HUT38892A publication Critical patent/HUT38892A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/26—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings
    • C07C55/28—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/32—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/34—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings containing more than one carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HU853002A 1984-06-22 1985-06-15 Process for preparing alpha-, omega-dicarboxylic acids and pharmaceutical compositions comprising the same as active substance HUT38892A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843423166 DE3423166A1 (de) 1984-06-22 1984-06-22 Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
PCT/EP1985/000288 WO1986000298A1 (en) 1984-06-22 1985-06-15 Alpha-, omega-dicarboxylic acids, process for their preparation and medicines composed thereof

Publications (1)

Publication Number Publication Date
HUT38892A true HUT38892A (en) 1986-07-28

Family

ID=6238954

Family Applications (1)

Application Number Title Priority Date Filing Date
HU853002A HUT38892A (en) 1984-06-22 1985-06-15 Process for preparing alpha-, omega-dicarboxylic acids and pharmaceutical compositions comprising the same as active substance

Country Status (17)

Country Link
US (1) US4711896A (hu)
EP (1) EP0185080B1 (hu)
JP (1) JPH0780807B2 (hu)
AU (1) AU4607185A (hu)
CA (1) CA1262552A (hu)
DD (1) DD240541A5 (hu)
DE (2) DE3423166A1 (hu)
DK (1) DK75986A (hu)
ES (1) ES8604090A1 (hu)
FI (1) FI860711A0 (hu)
GR (1) GR851509B (hu)
HU (1) HUT38892A (hu)
IL (1) IL75549A (hu)
NO (1) NO860661L (hu)
PT (1) PT80681B (hu)
WO (1) WO1986000298A1 (hu)
ZA (1) ZA854684B (hu)

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IL121165A0 (en) 1997-06-26 1997-11-20 Yissum Res Dev Co Pharmaceutical compositions containing carboxylic acids and derivatives thereof
DE60037818D1 (de) 1999-04-01 2008-03-06 Esperion Therapeutics Inc Ether-verbindungen, zusammensetzungen und ihre verwendung
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
EP1326822A2 (en) 2000-10-11 2003-07-16 Esperion Therapeutics Inc. Ketone compounds and compositions for cholesterol management and related uses
CA2425121A1 (en) 2000-10-11 2002-04-18 Esperion Therapeutics, Inc. Ether compounds and compositions for cholesterol management and related uses
US6703422B2 (en) 2000-10-11 2004-03-09 Esperion Therapeutics, Inc. Sulfide and disulfide compounds and compositions for cholesterol management and related uses
EP1366024A2 (en) 2000-10-11 2003-12-03 Esperion Therapeutics Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20040204502A1 (en) * 2001-10-11 2004-10-14 Dasseux Jean-Louis Henri Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US20040192771A1 (en) * 2001-10-11 2004-09-30 Dasseux Jean-Louis Henri Ether compounds and compositions for cholesterol management and related uses
US20050020694A1 (en) * 2001-10-11 2005-01-27 Dasseux Jean-Louis Henri Sulfide and disulfide compounds and compositions for cholesterol management and related uses
CA2480415A1 (en) * 2002-04-10 2003-10-23 Esperion Therapeutics, Inc. Mimics of acyl coenzyme-a, compositions thereof, and methods of cholesterol management and related uses
CA2491382A1 (en) * 2002-07-03 2004-01-15 Esperion Therapeutics, Inc. Compositions comprising panthetine for the treatment of dyslipidemia
US20040048910A1 (en) * 2002-08-22 2004-03-11 Bove Susan Elizabeth Method of treating osteoarthritis
SI2404890T1 (sl) * 2003-01-23 2017-12-29 Esperion Therapeutics Inc. Hidroksilne spojine in sestavki za uravnavanje holesterola in sorodne uporabe
WO2005002557A1 (en) * 2003-07-03 2005-01-13 Warner-Lambert Company Llc Pharmaceutical compositions including an ether and selective cox-2 inhibitor and uses thereof
WO2005046662A2 (en) * 2003-11-07 2005-05-26 Jj Pharma, Inc. Hdl-boosting combination therapy complexes
US20050192347A1 (en) * 2003-12-23 2005-09-01 Dasseux Jean-Louis H. Urea and thiourea compounds and compositions for cholesterol management and related uses
WO2005068412A1 (en) * 2003-12-24 2005-07-28 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
JP2007528369A (ja) * 2003-12-30 2007-10-11 シンドロメクス・リミテッド ３，３，１４，１４−テトラメチルヘキサデカン−１，１６−ジオイック酸の投与法
AU2005255013A1 (en) * 2004-06-09 2005-12-29 Avanir Pharmaceuticals Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia
PE20050986A1 (es) * 2004-06-09 2006-02-03 Avanir Pharmaceuticals Derivados heterociclicos mediadores del transporte inverso de colesterol
CA2568539A1 (en) * 2004-06-09 2005-12-29 Avanir Pharmaceuticals Small molecules for treatment of hypercholesterolemia and related diseases
WO2006045096A2 (en) * 2004-10-20 2006-04-27 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
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US8053440B2 (en) 2007-02-01 2011-11-08 Resverlogix Corporation Compounds for the prevention and treatment of cardiovascular diseases
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ES2532402T3 (es) 2008-06-26 2015-03-26 Resverlogix Corporation Métodos de preparación de derivados de quinazolinona
CA2747417C (en) 2009-01-08 2017-01-03 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
NZ708314A (en) 2009-03-18 2017-08-25 Resverlogix Corp Quinazolinones for use as anticancer agents
PL2421533T3 (pl) 2009-04-22 2019-05-31 Resverlogix Corp Nowe środki przeciwzapalne
PE20161551A1 (es) 2009-09-03 2017-01-18 Pfizer Vaccines Llc Vacuna de pcsk9
AU2011305610A1 (en) 2010-09-20 2013-03-14 Kareus Therapeutics, Sa Methods and compositions for treatment of diabetes and dyslipidemia
EP2680883B1 (en) 2011-03-02 2018-09-05 Pfizer Inc Pcsk9 vaccine
TR201909777T4 (tr) 2011-11-01 2019-07-22 Resverlogix Corp Sübsti̇tüe ki̇nazoli̇nonlara yöneli̇k oral çabuk salimli formülasyonlar
US10479752B2 (en) 2011-12-08 2019-11-19 Syndromex Ltd. Deuterated tetramethyl dioic acids, compositions comprising them and uses thereof
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
EP2935253B1 (en) 2012-12-21 2018-08-01 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
JO3789B1 (ar) 2015-03-13 2021-01-31 Resverlogix Corp التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة
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CN107118098B (zh) * 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
US10512624B2 (en) 2016-11-30 2019-12-24 Syndromex Ltd. Long-chain amphipathic dicarboxylic acids for treatment of diabetes type-1
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JP2024504720A (ja) * 2021-01-25 2024-02-01 エスパーヴィタ セラピューティクス，インコーポレイテッド 官能化長鎖炭化水素モノカルボン酸及びジカルボン酸ならびにそれらの誘導体、ならびに疾患の予防または治療のためのそれらの使用
CN115894220A (zh) * 2021-09-23 2023-04-04 中国科学院上海药物研究所 一类作用于acly的长链类化合物、其制备方法及其用途
CN115887435A (zh) * 2021-09-23 2023-04-04 博骥源（上海）生物医药有限公司 长链类化合物及其用途

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Also Published As

Publication number Publication date
FI860711A (fi) 1986-02-17
GR851509B (hu) 1985-06-25
US4711896A (en) 1987-12-08
JPH0780807B2 (ja) 1995-08-30
DK75986D0 (da) 1986-02-18
ZA854684B (en) 1986-02-26
JPS61502537A (ja) 1986-11-06
AU4607185A (en) 1986-01-24
PT80681A (de) 1985-07-01
NO860661L (no) 1986-02-21
DK75986A (da) 1986-02-18
PT80681B (de) 1987-05-08
CA1262552A (en) 1989-10-31
EP0185080A1 (hu) 1986-06-25
IL75549A (en) 1989-03-31
DE3423166A1 (de) 1986-01-02
WO1986000298A1 (en) 1986-01-16
IL75549A0 (en) 1985-10-31
FI860711A0 (fi) 1986-02-17
ES8604090A1 (es) 1986-02-01
DE3574130D1 (en) 1989-12-14
EP0185080B1 (de) 1989-11-08
DD240541A5 (de) 1986-11-05
ES544439A0 (es) 1986-02-01

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