HUP9901975A3 - Novel n,n'-bridged bis-indolyl-maleimides, their use as intermediates and pharmaceutical compositions containing them - Google Patents

Novel n,n'-bridged bis-indolyl-maleimides, their use as intermediates and pharmaceutical compositions containing them

Info

Publication number: HUP9901975A3
Authority: HU; Hungary
Prior art keywords: maleimides; indolyl; intermediates; novel; pharmaceutical compositions
Prior art date: 1995-11-20

Application number

HU9901975A

Other languages

English (en)

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-20

Filing date

1996-11-18

Publication date

2000-01-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21725638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9901975(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-11-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1999-11-29 Publication of HUP9901975A2 publication Critical patent/HUP9901975A2/hu

2000-01-28 Publication of HUP9901975A3 publication Critical patent/HUP9901975A3/hu

2007-07-30 Publication of HU225716B1 publication Critical patent/HU225716B1/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)

HU9901975A 1995-11-20 1996-11-18 Novel n,n'-bridged bis-indolyl-maleimides HU225716B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US734595P	1995-11-20	1995-11-20
PCT/US1996/018518 WO1997019080A1 (en)	1995-11-20	1996-11-18	Novel intermediates and their use to prepare n,n'-bridged bisindolylmaleimides

Publications (3)

Publication Number	Publication Date
HUP9901975A2 HUP9901975A2 (hu)	1999-11-29
HUP9901975A3 true HUP9901975A3 (en)	2000-01-28
HU225716B1 HU225716B1 (en)	2007-07-30

Family

ID=21725638

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9901975A HU225716B1 (en)	1995-11-20	1996-11-18	Novel n,n'-bridged bis-indolyl-maleimides

Country Status (31)

Country	Link
EP (1)	EP0776899B1 (hu)
JP (2)	JP4100708B2 (hu)
KR (1)	KR100342142B1 (hu)
CN (1)	CN1066734C (hu)
AR (2)	AR004719A1 (hu)
AT (1)	ATE191219T1 (hu)
AU (1)	AU701659B2 (hu)
BR (1)	BR9611709A (hu)
CA (1)	CA2237401C (hu)
CO (1)	CO4750824A1 (hu)
CZ (1)	CZ150398A3 (hu)
DE (1)	DE69607443T2 (hu)
DK (1)	DK0776899T3 (hu)
EA (1)	EA000639B1 (hu)
ES (1)	ES2145978T3 (hu)
GR (1)	GR3033729T3 (hu)
HU (1)	HU225716B1 (hu)
IL (1)	IL124415A (hu)
MX (1)	MX9803791A (hu)
MY (1)	MY118946A (hu)
NO (1)	NO310195B1 (hu)
NZ (1)	NZ323282A (hu)
PE (1)	PE17998A1 (hu)
PL (1)	PL184728B1 (hu)
PT (1)	PT776899E (hu)
TR (1)	TR199800876T2 (hu)
TW (1)	TW371661B (hu)
UA (1)	UA56145C2 (hu)
WO (1)	WO1997019080A1 (hu)
YU (1)	YU49316B (hu)
ZA (1)	ZA969645B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002506868A (ja) *	1998-03-13	2002-03-05	ザユニバーシティーオブブリティッシュコロンビア	癌治療において用いるためのグラニュラチミド誘導体
CA2245029A1 (en)	1998-03-13	1999-09-13	University Of British Columbia	Granulatimide compounds as g2 checkpoint inhibitors
US6127401A (en)	1998-06-05	2000-10-03	Cephalon, Inc.	Bridged indenopyrrolocarbazoles
US6300106B1 (en)	2000-11-22	2001-10-09	Ppg Industries Ohio, Inc.	Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate
EP2181999A1 (en)	2008-11-03	2010-05-05	Zentiva, A.S.	Method of manufacturing ruboxistarin
WO2023192984A1 (en) *	2022-03-31	2023-10-05	4M Therapeutics Inc.	N-desmethyl ruboxistaurin as kinase inhibitor
WO2024159211A1 (en) *	2023-01-27	2024-08-02	Mellicell, Inc.	Methods and compositions for treatment of obesity and diseases associated with fat cell enlargement

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL94274A0 (en) *	1989-05-05	1991-03-10	Goedecke Ag	Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5380746A (en) *	1989-05-05	1995-01-10	Goedecke Aktiengesellschaft	Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
PE49195A1 (es)	1993-12-07	1996-01-06	Lilly Co Eli	Inhibidor de proteinquinasa
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
US5559228A (en) *	1995-03-30	1996-09-24	Eli Lilly And Company	Synthesis of bisindolylmaleimides

1996
- 1996-11-18 EA EA199800368A patent/EA000639B1/ru not_active IP Right Cessation
- 1996-11-18 CN CN96199575A patent/CN1066734C/zh not_active Expired - Fee Related
- 1996-11-18 KR KR1019980703626A patent/KR100342142B1/ko not_active IP Right Cessation
- 1996-11-18 IL IL12441596A patent/IL124415A/xx not_active IP Right Cessation
- 1996-11-18 AT AT96308317T patent/ATE191219T1/de not_active IP Right Cessation
- 1996-11-18 CA CA002237401A patent/CA2237401C/en not_active Expired - Fee Related
- 1996-11-18 AU AU77388/96A patent/AU701659B2/en not_active Ceased
- 1996-11-18 EP EP96308317A patent/EP0776899B1/en not_active Expired - Lifetime
- 1996-11-18 TW TW085114104A patent/TW371661B/zh active
- 1996-11-18 ES ES96308317T patent/ES2145978T3/es not_active Expired - Lifetime
- 1996-11-18 JP JP51983897A patent/JP4100708B2/ja not_active Expired - Fee Related
- 1996-11-18 CZ CZ981503A patent/CZ150398A3/cs unknown
- 1996-11-18 UA UA98052516A patent/UA56145C2/uk unknown
- 1996-11-18 PE PE1996000828A patent/PE17998A1/es not_active Application Discontinuation
- 1996-11-18 NZ NZ323282A patent/NZ323282A/xx unknown
- 1996-11-18 WO PCT/US1996/018518 patent/WO1997019080A1/en not_active Application Discontinuation
- 1996-11-18 PL PL96326753A patent/PL184728B1/pl not_active IP Right Cessation
- 1996-11-18 TR TR1998/00876T patent/TR199800876T2/xx unknown
- 1996-11-18 DK DK96308317T patent/DK0776899T3/da active
- 1996-11-18 DE DE69607443T patent/DE69607443T2/de not_active Expired - Fee Related
- 1996-11-18 YU YU61096A patent/YU49316B/sh unknown
- 1996-11-18 HU HU9901975A patent/HU225716B1/hu not_active IP Right Cessation
- 1996-11-18 ZA ZA9609645A patent/ZA969645B/xx unknown
- 1996-11-18 PT PT96308317T patent/PT776899E/pt unknown
- 1996-11-18 BR BR9611709A patent/BR9611709A/pt not_active IP Right Cessation
- 1996-11-19 MY MYPI96004798A patent/MY118946A/en unknown
- 1996-11-19 CO CO96060836A patent/CO4750824A1/es unknown
- 1996-11-20 AR ARP960105257A patent/AR004719A1/es unknown
- 1996-11-20 AR ARP960105256A patent/AR004718A1/es unknown
1998
- 1998-05-08 NO NO19982105A patent/NO310195B1/no not_active IP Right Cessation
- 1998-05-13 MX MX9803791A patent/MX9803791A/es unknown
2000
- 2000-06-20 GR GR20000401423T patent/GR3033729T3/el not_active IP Right Cessation
2007
- 2007-12-28 JP JP2007338808A patent/JP2008138006A/ja not_active Ceased

Also Published As

Publication number	Publication date
ATE191219T1 (de)	2000-04-15
PT776899E (pt)	2000-08-31
CZ150398A3 (cs)	1998-12-16
HUP9901975A2 (hu)	1999-11-29
DE69607443D1 (de)	2000-05-04
ZA969645B (en)	1998-05-18
YU49316B (sh)	2005-06-10
TW371661B (en)	1999-10-11
UA56145C2 (uk)	2003-05-15
NO982105L (no)	1998-05-08
JP2000500496A (ja)	2000-01-18
CN1207740A (zh)	1999-02-10
PL184728B1 (pl)	2002-12-31
DE69607443T2 (de)	2000-08-10
AR004719A1 (es)	1999-03-10
CO4750824A1 (es)	1999-03-31
EA199800368A1 (ru)	1998-12-24
IL124415A (en)	2003-11-23
CA2237401C (en)	2003-10-21
AU701659B2 (en)	1999-02-04
GR3033729T3 (en)	2000-10-31
BR9611709A (pt)	1999-02-23
MX9803791A (es)	1998-09-30
PL326753A1 (en)	1998-10-26
EA000639B1 (ru)	1999-12-29
CA2237401A1 (en)	1997-05-29
MY118946A (en)	2005-02-28
CN1066734C (zh)	2001-06-06
NO310195B1 (no)	2001-06-05
ES2145978T3 (es)	2000-07-16
JP2008138006A (ja)	2008-06-19
NZ323282A (en)	1999-01-28
WO1997019080A1 (en)	1997-05-29
HU225716B1 (en)	2007-07-30
AR004718A1 (es)	1999-03-10
AU7738896A (en)	1997-06-11
IL124415A0 (en)	1998-12-06
DK0776899T3 (da)	2000-07-10
PE17998A1 (es)	1998-04-20
EP0776899B1 (en)	2000-03-29
YU61096A (sh)	1999-03-04
EP0776899A1 (en)	1997-06-04
TR199800876T2 (xx)	1998-08-21
NO982105D0 (no)	1998-05-08
JP4100708B2 (ja)	2008-06-11
KR19990067600A (ko)	1999-08-25
KR100342142B1 (ko)	2002-08-22

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ZA96525B (en)	1996-08-06	Novel pharmaceutical compositions
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HUP9901975A3 (en)	2000-01-28	Novel n,n'-bridged bis-indolyl-maleimides, their use as intermediates and pharmaceutical compositions containing them
GR3036411T3 (en)	2001-11-30	Novel taxoids, preparation thereof and pharmaceutical compositions containing same
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Legal Events

Date	Code	Title	Description
2009-07-28	MM4A	Lapse of definitive patent protection due to non-payment of fees