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HUP9702360A2 - Eljárás L-lizin előállítására - Google Patents

Eljárás L-lizin előállítására

Info

Publication number
HUP9702360A2
HUP9702360A2 HU9702360A HUP9702360A HUP9702360A2 HU P9702360 A2 HUP9702360 A2 HU P9702360A2 HU 9702360 A HU9702360 A HU 9702360A HU P9702360 A HUP9702360 A HU P9702360A HU P9702360 A2 HUP9702360 A2 HU P9702360A2
Authority
HU
Hungary
Prior art keywords
lysine
dna sequence
production
encoding
subject
Prior art date
Application number
HU9702360A
Other languages
English (en)
Inventor
Masayuki Araki
Tsuyoshi Nakamatsu
Masakazu Sugimoto
Yasuhiko Yoshihara
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18179293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9702360(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of HU9702360D0 publication Critical patent/HU9702360D0/hu
Publication of HUP9702360A2 publication Critical patent/HUP9702360A2/hu
Publication of HUP9702360A3 publication Critical patent/HUP9702360A3/hu
Publication of HU224492B1 publication Critical patent/HU224492B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A találmány tárgyát egy kőrinefőrm baktériűm képezi, amely őlyanaszpartőkinázt hőrdőz, amely aszpartőkinázban az L-lizin és L-treőninőkőzta visszacsatőlásős gátlással szembeni érzékenység lényegesen levan csökkentve, és amely baktériűm tartalmaz egy, dihidrőpikőlinátredűktázt kódőló, főkőzőtt aktivitású DNS-szekvenciát, egy,dihidrőpikőlinát szintázt kódőló, főkőzőtt aktivitású DNS-szekvenciát,egy, diaminőpimelát dekarbőxilázt kódőló, főkőzőtt aktivitású DNS-szekvenciát és egy, aszpartát aminőtranszferázt kódőló, főkőzőttaktivitású DNS-szekvenciát. A találmány tárgyát képezi tővábbá eljárásL-lizin termelésére, amely sőrán az említett kőrinefőrm baktériűmőtmegfelelő tápközegben tenyésztik, ami lehetővé teszi L-lizintermelődését és felhalmőzódását a baktériűmsejt-tenyészetben, majd azL-lizint a tenyészetből kinyerik. A találmány tárgyát képezi egyrekőmbináns DNS is, amely alkalmas találmány szerinti kőrinefőrmbaktériűmők előállítására. A találmány szerinti megőldás alkalmas L-lizin ipari méretekben történő előállítására. ŕ
HU9702360A 1996-12-05 1997-12-05 Eljárás L-lizin előállítására HU224492B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP32565996 1996-12-05

Publications (4)

Publication Number Publication Date
HU9702360D0 HU9702360D0 (en) 1998-03-02
HUP9702360A2 true HUP9702360A2 (hu) 1999-06-28
HUP9702360A3 HUP9702360A3 (en) 2002-12-28
HU224492B1 HU224492B1 (hu) 2005-09-28

Family

ID=18179293

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702360A HU224492B1 (hu) 1996-12-05 1997-12-05 Eljárás L-lizin előállítására

Country Status (10)

Country Link
US (1) US6004773A (hu)
EP (1) EP0854189B1 (hu)
CN (2) CN1273592C (hu)
BR (1) BR9706059B1 (hu)
DE (1) DE69736698T2 (hu)
DK (1) DK0854189T3 (hu)
ES (1) ES2273355T3 (hu)
HU (1) HU224492B1 (hu)
PL (1) PL190430B1 (hu)
SK (1) SK285201B6 (hu)

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CA2224058C (en) 1995-06-07 2011-09-13 Ajinomoto Co., Inc. Method of producing l-lysine
JP4075087B2 (ja) 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
DE19931317A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin
JP2003135066A (ja) * 1999-03-19 2003-05-13 Ajinomoto Co Inc Ｌ−リジンの製造法
ES2177475T1 (es) * 1999-06-25 2002-12-16 Basf Ag Genes de corynebacterium glutamicum que codifican proteinas de una ruta metabolica.
JP2003169674A (ja) * 1999-07-02 2003-06-17 Ajinomoto Co Inc Ｌ−リジンの製造法
CN1298854C (zh) 1999-07-02 2007-02-07 味之素株式会社 编码蔗糖pts酶ⅱ的dna
JP2003159092A (ja) * 1999-07-02 2003-06-03 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
US6861246B2 (en) 1999-07-07 2005-03-01 Degussa Ag L-lysine-producing corynebacteria and process for the preparation of lysine
DE19931314A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
US20020086371A1 (en) 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
DE19943587A1 (de) 1999-09-11 2001-03-15 Degussa Neue für das dapF-Gen codierende Nukleotidsequenzen
IL148564A0 (en) 1999-09-15 2002-09-12 Basf Plant Science Gmbh Plants having altered amino acid contents and method for the production thereof
CN1230525C (zh) * 1999-12-24 2005-12-07 味之素株式会社 生产l－氨基酸的方法和新型基因
US6927046B1 (en) 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
EP1317546A2 (en) * 2000-09-12 2003-06-11 Degussa AG Nucleotide sequences which code for the gora gene
IL156997A0 (en) 2001-02-08 2004-02-08 Archer Daniels Midland Co Polynucleotide constructs for increased lysine production
DE10154292A1 (de) * 2001-11-05 2003-05-15 Basf Ag Gene die für Stoffwechselweg-Proteine codieren
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BRPI0516261A (pt) 2004-10-07 2008-08-26 Ajinomoto Kk método para produzir uma substãncia básica por fermentação, e, caldo de fermentação ou produto de fermentação contendo uma substáncia básica
KR100628394B1 (ko) 2005-01-04 2006-09-26 씨제이 주식회사 코리네박테리움의 알라닌 아미노트랜스퍼레이즈 유전자의결실을 통한 알라닌 요구주의 제작 및 이를 이용한엘-라이신의 생산방법
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EP1881076A1 (en) * 2006-07-17 2008-01-23 Evonik Degussa GmbH Method for producing L-amino acids
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KR100830826B1 (ko) 2007-01-24 2008-05-19 씨제이제일제당 (주) 코리네박테리아를 이용하여 글리세롤을 포함한탄소원으로부터 발효산물을 생산하는 방법
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US8932861B2 (en) 2008-04-10 2015-01-13 Cj Cheiljedang Corporation Transformation vector comprising transposon, microorganisms transformed with the vector, and method for producing L-lysine using the microorganism
KR101126041B1 (ko) 2008-04-10 2012-03-19 씨제이제일제당 (주) 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 ｌ-라이신 생산방법
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BR112015023583A2 (pt) 2013-03-15 2017-08-22 Dow Global Technologies Llc Método para vaporização 3-hp a partir de uma solução, vapor, solução 3-hp condensada, composição, produto químico à jusante, produto de consumo, sistema para purificação de 3-hp, método para produzir uma solução de 3-hp, método para decompor a amônia de 3-hp (a3-hp) e método para decompor a3-hp
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CA2180202A1 (en) * 1995-06-30 1996-12-31 Mika Moriya Method of amplifying gene using artificial transposon

Also Published As

Publication number Publication date
CN1273592C (zh) 2006-09-06
DE69736698T2 (de) 2007-09-20
HU9702360D0 (en) 1998-03-02
CN1159443C (zh) 2004-07-28
EP0854189A3 (en) 2002-11-06
DE69736698D1 (de) 2006-11-02
SK285201B6 (sk) 2006-08-03
EP0854189A2 (en) 1998-07-22
PL190430B1 (pl) 2005-12-30
HUP9702360A3 (en) 2002-12-28
BR9706059A (pt) 1999-10-05
US6004773A (en) 1999-12-21
DK0854189T3 (da) 2007-01-15
PL323546A1 (en) 1998-06-08
CN1524956A (zh) 2004-09-01
CN1187540A (zh) 1998-07-15
ES2273355T3 (es) 2007-05-01
EP0854189B1 (en) 2006-09-20
BR9706059B1 (pt) 2012-02-22
HU224492B1 (hu) 2005-09-28
SK163697A3 (en) 1998-07-08

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Effective date: 20050808