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HUP1600269A2 - Lumacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyászati készítményei - Google Patents

Lumacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyászati készítményei

Info

Publication number
HUP1600269A2
HUP1600269A2 HU1600269A HUP1600269A HUP1600269A2 HU P1600269 A2 HUP1600269 A2 HU P1600269A2 HU 1600269 A HU1600269 A HU 1600269A HU P1600269 A HUP1600269 A HU P1600269A HU P1600269 A2 HUP1600269 A2 HU P1600269A2
Authority
HU
Hungary
Prior art keywords
lumacaftor
complexes
derivatives
salts
preparation
Prior art date
Application number
HU1600269A
Other languages
English (en)
Inventor
Richard Balazs Karpati
Ordasi Betti Szabone
Orsolya Basa-Denes
Erzsebet Reka Angi
Tamas Jordan
Molnar Laszlo Dr
Glavinas Hristos Dr
Oetvoes Zsolt Dr
Filipcsei Genoveva Dr
Original Assignee
Druggability Tech Ip Holdco Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Druggability Tech Ip Holdco Ltd filed Critical Druggability Tech Ip Holdco Ltd
Priority to HU1600269A priority Critical patent/HUP1600269A2/hu
Priority to CN201780039665.5A priority patent/CN109475547A/zh
Priority to CA3021941A priority patent/CA3021941A1/en
Priority to AU2017256182A priority patent/AU2017256182A1/en
Priority to JP2018555731A priority patent/JP2019514897A/ja
Priority to EP17731268.3A priority patent/EP3448385A1/en
Priority to PCT/IB2017/052372 priority patent/WO2017187338A1/en
Publication of HUP1600269A2 publication Critical patent/HUP1600269A2/hu
Priority to IL262490A priority patent/IL262490A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Preparation (AREA)
HU1600269A 2016-04-25 2016-04-25 Lumacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyászati készítményei HUP1600269A2 (hu)

Priority Applications (8)

Application Number Priority Date Filing Date Title
HU1600269A HUP1600269A2 (hu) 2016-04-25 2016-04-25 Lumacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyászati készítményei
CN201780039665.5A CN109475547A (zh) 2016-04-25 2017-04-25 鲁玛卡托及其盐和衍生物的复合物、其制备方法以及含有它们的药物组合物
CA3021941A CA3021941A1 (en) 2016-04-25 2017-04-25 Complexes of lumacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
AU2017256182A AU2017256182A1 (en) 2016-04-25 2017-04-25 Complexes of lumacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
JP2018555731A JP2019514897A (ja) 2016-04-25 2017-04-25 ルマカフトールおよびその塩および誘導体の複合体、それらの調製方法およびそれらを含有する医薬組成物
EP17731268.3A EP3448385A1 (en) 2016-04-25 2017-04-25 Complexes of lumacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
PCT/IB2017/052372 WO2017187338A1 (en) 2016-04-25 2017-04-25 Complexes of lumacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
IL262490A IL262490A (en) 2016-04-25 2018-10-21 Lomacaptor complexes and their salts and derivatives, a process for their preparation and pharmaceutical preparations containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1600269A HUP1600269A2 (hu) 2016-04-25 2016-04-25 Lumacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyászati készítményei

Publications (1)

Publication Number Publication Date
HUP1600269A2 true HUP1600269A2 (hu) 2017-10-30

Family

ID=89992147

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1600269A HUP1600269A2 (hu) 2016-04-25 2016-04-25 Lumacaftornak, sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyászati készítményei

Country Status (8)

Country Link
EP (1) EP3448385A1 (hu)
JP (1) JP2019514897A (hu)
CN (1) CN109475547A (hu)
AU (1) AU2017256182A1 (hu)
CA (1) CA3021941A1 (hu)
HU (1) HUP1600269A2 (hu)
IL (1) IL262490A (hu)
WO (1) WO2017187338A1 (hu)

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SI2774925T1 (sl) 2005-11-08 2017-04-26 Vertex Pharmaceuticals Incorporated Heterociklični modulatorji prenašalcev z ATP-vezavno kaseto
NZ586272A (en) 2007-12-07 2012-05-25 Vertex Pharma Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
CN103626744B (zh) 2007-12-07 2016-05-11 沃泰克斯药物股份有限公司 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的固体形式
BRPI0919550A2 (pt) 2008-09-29 2019-09-10 Vertex Pharma unidades de dosagem de ácido 3-(6-(1-(2,2-difluorobenzo]d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico
PL2555754T3 (pl) 2010-04-07 2016-09-30 Formy stałe kwasu 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-ilo)cyklopropanokarboksyamido)-3-metylopirydyn-2-ylo)benzoesowego
RS62767B1 (sr) * 2010-04-07 2022-01-31 Vertex Pharma Farmaceutski sastavi 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiriodin-2-il)benzojeve kiseline i njihova primena
NZ727015A (en) 2012-01-25 2017-12-22 Vertex Pharma Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
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AU2017256182A1 (en) 2018-12-13
CA3021941A1 (en) 2017-11-02
IL262490A (en) 2018-12-31
JP2019514897A (ja) 2019-06-06
WO2017187338A1 (en) 2017-11-02
WO2017187338A4 (en) 2017-12-28

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