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HUP0303084A2 - Gyulladásgátló hatású 17béta-karbotioát-17alfa-arilkarboniloxiloxi androsztán-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Gyulladásgátló hatású 17béta-karbotioát-17alfa-arilkarboniloxiloxi androsztán-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0303084A2
HUP0303084A2 HU0303084A HUP0303084A HUP0303084A2 HU P0303084 A2 HUP0303084 A2 HU P0303084A2 HU 0303084 A HU0303084 A HU 0303084A HU P0303084 A HUP0303084 A HU P0303084A HU P0303084 A2 HUP0303084 A2 HU P0303084A2
Authority
HU
Hungary
Prior art keywords
arylcarbonyloxyloxy
carbothioate
beta
alpha
compounds
Prior art date
Application number
HU0303084A
Other languages
English (en)
Inventor
Keith Biggadike
Paul Jones
Jeremy John Payne
Original Assignee
Glaxo Group Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26244792&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0303084(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB0019172.6A external-priority patent/GB0019172D0/en
Priority claimed from GBGB0108800.4A external-priority patent/GB0108800D0/en
Application filed by Glaxo Group Ltd. filed Critical Glaxo Group Ltd.
Publication of HUP0303084A2 publication Critical patent/HUP0303084A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya (I) általános képletű vegyületek, sói és szolvátjai- a képletben R1 jelentése 1-6 szénatomos alkil- vagy 1-6 szénatomoshalogénalkil-, R2 jelentése -C(=O)-aril- vagy -C(=O)-heteroaril-, R3jelentése hidrogénatom, metil- (ez lehet a vagy b konfigurációjú) vagymetiléncsoport, R4 és R5 azonos vagy különböző és jelentésük hidrogén-vagy halogénatom, és _ _ _ jelentése egyes- vagy kettőskötés. Atalálmány vonatkozik továbbá a fenti (I) általános képletűvegyületeket tartalmazó gyógyszerkészítményekre, a vegyületek és agyógyszerkészítmények humán- és állatgyógyászati szerként valóalkalmazására, a vegyületek előállítási eljárására, valamint azelőállítási eljárásnál felhasználásra kerülő új intermedierekre. Ó
HU0303084A 2000-08-05 2001-08-03 Gyulladásgátló hatású 17béta-karbotioát-17alfa-arilkarboniloxiloxi androsztán-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények HUP0303084A2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0019172.6A GB0019172D0 (en) 2000-08-05 2000-08-05 Novel compounds
GBGB0108800.4A GB0108800D0 (en) 2001-04-07 2001-04-07 Novel compounds
PCT/GB2001/003499 WO2002012266A1 (en) 2000-08-05 2001-08-03 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
HUP0303084A2 true HUP0303084A2 (hu) 2003-12-29

Family

ID=26244792

Family Applications (3)

Application Number Title Priority Date Filing Date
HU0303354A HU230328B1 (hu) 2000-08-05 2001-08-03 Gyulladásgátló szerként alkalmazható 6-alfa,9-alfa-difluor-17-alfa-(2-furanilkarbonil)oxi-11-béta-hidroxi-16-alfametil-3-oxo-androszta-1,4-dién-17-tiokarbonsav-S-fluormetil-észter
HU0303084A HUP0303084A2 (hu) 2000-08-05 2001-08-03 Gyulladásgátló hatású 17béta-karbotioát-17alfa-arilkarboniloxiloxi androsztán-származékok, eljárás az előállításukra, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
HUS1600012C HUS1600012I1 (hu) 2000-08-05 2016-03-11 Gyulladásgátló szerként alkalmazható 6-alfa,9-alfa-difluor-17-alfa-(2-furanilkarbonil)oxi-11-béta-hidroxi-16-alfa- metil-3-oxo-androszta-1,4-dién-17-tiokarbonsav-S-fluormetil-észter

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0303354A HU230328B1 (hu) 2000-08-05 2001-08-03 Gyulladásgátló szerként alkalmazható 6-alfa,9-alfa-difluor-17-alfa-(2-furanilkarbonil)oxi-11-béta-hidroxi-16-alfametil-3-oxo-androszta-1,4-dién-17-tiokarbonsav-S-fluormetil-észter

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUS1600012C HUS1600012I1 (hu) 2000-08-05 2016-03-11 Gyulladásgátló szerként alkalmazható 6-alfa,9-alfa-difluor-17-alfa-(2-furanilkarbonil)oxi-11-béta-hidroxi-16-alfa- metil-3-oxo-androszta-1,4-dién-17-tiokarbonsav-S-fluormetil-észter

Country Status (36)

Country Link
US (3) US7498321B2 (hu)
EP (5) EP1305330B1 (hu)
JP (3) JP4436041B2 (hu)
KR (3) KR20030071751A (hu)
CN (4) CN100513416C (hu)
AP (1) AP1422A (hu)
AR (3) AR032471A1 (hu)
AT (2) ATE416184T1 (hu)
AU (4) AU7576001A (hu)
BG (1) BG66241B1 (hu)
BR (2) BRPI0113042B8 (hu)
CA (3) CA2417825C (hu)
CO (2) CO5310534A1 (hu)
CY (4) CY1107899T1 (hu)
CZ (2) CZ2003353A3 (hu)
DE (3) DE60136818D1 (hu)
DK (3) DK2348032T3 (hu)
DZ (1) DZ3468A1 (hu)
EA (1) EA005992B1 (hu)
ES (4) ES2317922T3 (hu)
FR (1) FR08C0014I2 (hu)
HK (2) HK1056180B (hu)
HU (3) HU230328B1 (hu)
IL (4) IL154148A0 (hu)
LU (1) LU91429I2 (hu)
MA (1) MA25899A1 (hu)
MX (2) MXPA03001097A (hu)
NL (1) NL300343I2 (hu)
NO (4) NO324747B1 (hu)
NZ (2) NZ523958A (hu)
OA (1) OA12394A (hu)
PL (2) PL213373B1 (hu)
PT (3) PT1775305E (hu)
SI (3) SI1305329T2 (hu)
SK (1) SK287576B6 (hu)
WO (2) WO2002012265A1 (hu)

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