HUP0300489A2 - Új fehérje és a fehérjét kódoló gén - Google Patents
Új fehérje és a fehérjét kódoló génInfo
- Publication number
- HUP0300489A2 HUP0300489A2 HU0300489A HUP0300489A HUP0300489A2 HU P0300489 A2 HUP0300489 A2 HU P0300489A2 HU 0300489 A HU0300489 A HU 0300489A HU P0300489 A HUP0300489 A HU P0300489A HU P0300489 A2 HUP0300489 A2 HU P0300489A2
- Authority
- HU
- Hungary
- Prior art keywords
- protein
- same
- gene encoding
- mechanical stimulus
- novel protein
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 102000004169 proteins and genes Human genes 0.000 title abstract 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 108091005462 Cation channels Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
Abstract
A találmány új, mechanikai ingerre érzékeny (un. <mechanoszenzitív<)csatornaképző fehérjére és a fehérjét kódoló DNS-re vonatkozik. Atalálmány kiterjed egy kationcsatorna-aktivátorok vagy inhibitorokkiszűrésére szolgáló eljárásra (screening) az említett fehérjealkalmazásával, valamint a fehérjéhez való antitestekre is. A fehérjespecifikusan a vesében expresszálódik és származhat egérből (SAC1)vagy emberből (hSAC). Az a funkciója, hogy mechanikai inger hatásáranem szelektíven kationokat transzportál sejtekbe. A fehérjediagnosztikai vagy terápiás szerként alkalmazható a kationcsatornarendellenességein alapuló megbetegedések (pl. magas vérnyomás vagycukorbetegség) esetén. Hasznos eszköznek bizonyulhat olyan vegyianyagok kiszűrésére is, amelyek ezeknek a betegségeknek a megelőzéséreés/vagy kezelésére szolgálnak. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000048727 | 2000-02-25 | ||
| PCT/JP2001/001354 WO2001062915A1 (fr) | 2000-02-25 | 2001-02-23 | Nouvelle proteine et gene codant pour elle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0300489A2 true HUP0300489A2 (hu) | 2003-08-28 |
| HUP0300489A3 HUP0300489A3 (en) | 2006-06-28 |
Family
ID=18570772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300489A HUP0300489A3 (en) | 2000-02-25 | 2001-02-23 | Novel protein and gene encoding the same |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20030073117A1 (hu) |
| EP (1) | EP1260585A4 (hu) |
| JP (1) | JPWO2001062915A1 (hu) |
| KR (1) | KR20030004354A (hu) |
| CN (1) | CN1432062A (hu) |
| AU (1) | AU2001234150A1 (hu) |
| CA (1) | CA2400876A1 (hu) |
| HU (1) | HUP0300489A3 (hu) |
| NO (1) | NO20024029L (hu) |
| WO (1) | WO2001062915A1 (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL213159B1 (pl) | 2010-04-23 | 2013-01-31 | Inst Biolog Doswiadczalnej Im Marcelego Nenckiego Pan | Zmutowane szczepy Escherichia coli, sposób testowania potencjalnych zwiazków antybakteryjnych wykorzystujacy te szczepy oraz zestaw do testowania |
| CN102199197B (zh) * | 2011-04-13 | 2013-03-27 | 安徽医科大学 | 一种具有自组装钾通道功能的多肽及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2298540A1 (en) * | 1997-08-20 | 1999-02-25 | David J. Julius | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
| CA2309903C (en) * | 1998-01-22 | 2012-03-27 | The Regents Of The University Of California | Nucleic acid sequences encoding capsaicin receptor |
| GB9826359D0 (en) * | 1998-12-01 | 1999-01-27 | Glaxo Group Ltd | Novel receptors |
| WO2001034805A2 (en) * | 1999-11-12 | 2001-05-17 | Abbott Laboratories | Human vanilloid receptor gene |
| US20020072101A1 (en) * | 2000-01-21 | 2002-06-13 | Gaughan Glen T. | Novel human nucleic acid molecules and polypeptides encoding cation channels |
| US6455278B1 (en) * | 2000-02-08 | 2002-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding human vanilloid receptor VR3 |
| EP1170365A1 (en) * | 2000-07-04 | 2002-01-09 | Smithkline Beecham Plc | Member of the ion channel family of polypeptides; vanilrep4 |
-
2001
- 2001-02-23 WO PCT/JP2001/001354 patent/WO2001062915A1/ja not_active Application Discontinuation
- 2001-02-23 AU AU2001234150A patent/AU2001234150A1/en not_active Abandoned
- 2001-02-23 KR KR1020027010913A patent/KR20030004354A/ko not_active Application Discontinuation
- 2001-02-23 EP EP01906253A patent/EP1260585A4/en not_active Withdrawn
- 2001-02-23 CA CA002400876A patent/CA2400876A1/en not_active Abandoned
- 2001-02-23 HU HU0300489A patent/HUP0300489A3/hu unknown
- 2001-02-23 JP JP2001562689A patent/JPWO2001062915A1/ja active Pending
- 2001-02-23 CN CN01805652A patent/CN1432062A/zh active Pending
-
2002
- 2002-08-23 NO NO20024029A patent/NO20024029L/no not_active Application Discontinuation
- 2002-08-23 US US10/227,255 patent/US20030073117A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030004354A (ko) | 2003-01-14 |
| US20030073117A1 (en) | 2003-04-17 |
| NO20024029D0 (no) | 2002-08-23 |
| EP1260585A1 (en) | 2002-11-27 |
| AU2001234150A1 (en) | 2001-09-03 |
| EP1260585A4 (en) | 2005-02-02 |
| CA2400876A1 (en) | 2001-08-30 |
| CN1432062A (zh) | 2003-07-23 |
| HUP0300489A3 (en) | 2006-06-28 |
| NO20024029L (no) | 2002-10-24 |
| JPWO2001062915A1 (ja) | 2004-01-08 |
| WO2001062915A1 (fr) | 2001-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |