HUP0204168A2 - Butyne diol derivatives, pharmaceutical composition containing the same and its preparation - Google Patents
Butyne diol derivatives, pharmaceutical composition containing the same and its preparationInfo
- Publication number
- HUP0204168A2 HUP0204168A2 HU0204168A HUP0204168A HUP0204168A2 HU P0204168 A2 HUP0204168 A2 HU P0204168A2 HU 0204168 A HU0204168 A HU 0204168A HU P0204168 A HUP0204168 A HU P0204168A HU P0204168 A2 HUP0204168 A2 HU P0204168A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- optionally substituted
- substituted phenyl
- atom
- sulfur
- Prior art date
Links
- -1 Butyne diol Chemical class 0.000 title abstract 3
- KDKYADYSIPSCCQ-UHFFFAOYSA-N ethyl acetylene Natural products CCC#C KDKYADYSIPSCCQ-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány szerinti (I) általános képletű butin-diol-származékokáltalános képletében R1 adott esetben szubsztituált fenilcsoportot, 2-piridil-csoportot, 5-alkil-2-piridil-csoportot vagy egy vagy kétnitrogén-, kén- és/vagy oxigén-heteroatomot tartalmazó öttagúheteroarilcsoportot jelent; R2 jelentése hidrogénatom; alkilcsoport;adott esetben szubsztituált fenilcsoport; egy vagy két nitrogén-, kén-és/vagy oxigénatomot tartalmazó, adott esetben szubsztituált öttagúheteroarilcsoport; adott esetben szubsztituált benzilcsoport; adottesetben szubsztituált 2-pirimidil-csoport; vagy -C(A)-B-Ra általánosképletű csoport, amelyben A oxigénatomot vagy kénatomot jelent, B -NH-csoportot jelent, és Ra alkilcsoportot, cikloalkilcsoportot, adottesetben szubsztituált fenilcsoportot, vagy egy vagy két nitrogénatomottartalmazó, adott esetben szubsztituált hattagú heteroarilcsoportotképvisel; R3 adott esetben szubsztituált fenilcsoportot jelent; R4jelentése hidrogénatom, halogénatom, trifluor-metil-csoport,alkilcsoport, alkoxicsoport, alkil-tio-csoport, alkil-oxi-alkil-csoport, heteroarilcsoport, heterociklusos csoport, vagy adott esetbenszubsztituált fenilcsoport, és X oxigénatomot, kénatomot vagyvegyértékkötést jelent. ÓIn the general formula of the butylene diol derivatives of the general formula (I) according to the invention, R1 optionally contains a substituted phenyl group, a 2-pyridyl group, a 5-alkyl-2-pyridyl group or one or two nitrogen, sulfur and/or oxygen heteroatoms represents a five-membered heteroaryl group; R 2 is a hydrogen atom; alkyl group; optionally substituted phenyl group; an optionally substituted five-membered heteroaryl group containing one or two nitrogen, sulfur and/or oxygen atoms; optionally substituted benzyl; optionally substituted 2-pyrimidyl; or a group of the general formula -C(A)-B-Ra, in which A represents an oxygen atom or a sulfur atom, B represents an -NH group, and Ra represents an alkyl group, a cycloalkyl group, an optionally substituted phenyl group, or an optionally substituted six-membered heteroaryl group containing one or two nitrogen atoms; R3 optionally represents a substituted phenyl group; R4 is a hydrogen atom, a halogen atom, a trifluoromethyl group, an alkyl group, an alkoxy group, an alkylthio group, an alkyloxyalkyl group, a heteroaryl group, a heterocyclic group, or an optionally substituted phenyl group, and X is an oxygen atom, a sulfur atom, or a valence bond. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP9910276 | 1999-12-22 | ||
| PCT/EP2000/012743 WO2001046156A1 (en) | 1999-12-22 | 2000-12-14 | Butyne diol derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0204168A2 true HUP0204168A2 (en) | 2003-04-28 |
Family
ID=8167542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0204168A HUP0204168A2 (en) | 1999-12-22 | 2000-12-14 | Butyne diol derivatives, pharmaceutical composition containing the same and its preparation |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JP2003518102A (en) |
| KR (1) | KR20020068373A (en) |
| CN (1) | CN1407973A (en) |
| AU (1) | AU3536701A (en) |
| BR (1) | BR0016241A (en) |
| CA (1) | CA2389479A1 (en) |
| HU (1) | HUP0204168A2 (en) |
| IL (1) | IL149529A0 (en) |
| MX (1) | MXPA02006250A (en) |
| NO (1) | NO20022971D0 (en) |
| WO (1) | WO2001046156A1 (en) |
| ZA (1) | ZA200203796B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001263850A1 (en) * | 2000-04-20 | 2001-11-07 | Actelion Pharmaceuticals Ltd | Pyrimidine-sulfonamides having endothelin-antagonist activity |
| JP4245130B2 (en) * | 2000-12-18 | 2009-03-25 | アクテリオン ファーマシューティカルズ リミテッド | New sulfamides |
| KR101245075B1 (en) | 2004-06-08 | 2013-03-18 | 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 | New disubstituted phenylpiperidines/piperazines as modulators of dopamine neurotransmission |
| AR062501A1 (en) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | THERAPEUTIC COMPOSITIONS |
| MX2010001837A (en) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Iron with actively cooled soleplate and method for cooling the soleplate. |
| US8916385B2 (en) * | 2007-12-13 | 2014-12-23 | Quest Diagnostics Investments, Inc. | Methods for detecting estrone by mass spectrometry |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2086544C1 (en) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity |
| CA2162630C (en) * | 1994-11-25 | 2007-05-01 | Volker Breu | Sulfonamides |
| TW313568B (en) * | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
| US5962682A (en) * | 1994-12-20 | 1999-10-05 | Hoffmann-La Roche Inc. | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists |
| US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
| CZ260596A3 (en) * | 1995-10-12 | 1997-12-17 | Hoffmann La Roche | Sulfonamide derivative, process of its preparation and pharmaceutical composition containing thereof |
| US6083955A (en) * | 1995-12-20 | 2000-07-04 | Yamanouchi Pharmaceutical Co., Ltd. | Arylethenesulfonamide derivatives and drug composition containing the same |
| AU3459697A (en) * | 1996-07-23 | 1998-02-10 | Shionogi & Co., Ltd. | Novel pyrimidine compounds and drug compositions |
| WO1999036408A1 (en) * | 1998-01-19 | 1999-07-22 | Shionogi & Co., Ltd. | Novel pyrimidine derivatives |
-
2000
- 2000-12-14 JP JP2001547067A patent/JP2003518102A/en active Pending
- 2000-12-14 IL IL14952900A patent/IL149529A0/en unknown
- 2000-12-14 WO PCT/EP2000/012743 patent/WO2001046156A1/en not_active Application Discontinuation
- 2000-12-14 BR BR0016241-8A patent/BR0016241A/en not_active Application Discontinuation
- 2000-12-14 MX MXPA02006250A patent/MXPA02006250A/en unknown
- 2000-12-14 HU HU0204168A patent/HUP0204168A2/en unknown
- 2000-12-14 KR KR1020027007566A patent/KR20020068373A/en not_active Application Discontinuation
- 2000-12-14 CN CN00816718A patent/CN1407973A/en active Pending
- 2000-12-14 AU AU35367/01A patent/AU3536701A/en not_active Abandoned
- 2000-12-14 CA CA002389479A patent/CA2389479A1/en not_active Abandoned
-
2002
- 2002-05-13 ZA ZA200203796A patent/ZA200203796B/en unknown
- 2002-06-20 NO NO20022971A patent/NO20022971D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1407973A (en) | 2003-04-02 |
| MXPA02006250A (en) | 2004-09-06 |
| ZA200203796B (en) | 2003-10-29 |
| BR0016241A (en) | 2002-11-12 |
| JP2003518102A (en) | 2003-06-03 |
| NO20022971L (en) | 2002-06-20 |
| WO2001046156A1 (en) | 2001-06-28 |
| KR20020068373A (en) | 2002-08-27 |
| IL149529A0 (en) | 2002-11-10 |
| CA2389479A1 (en) | 2001-06-28 |
| AU3536701A (en) | 2001-07-03 |
| NO20022971D0 (en) | 2002-06-20 |
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