HUP0401596A2 - Összekapcsolt glikopeptid-kefalosporin antibiotikumok és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Összekapcsolt glikopeptid-kefalosporin antibiotikumok és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0401596A2 HUP0401596A2 HU0401596A HUP0401596A HUP0401596A2 HU P0401596 A2 HUP0401596 A2 HU P0401596A2 HU 0401596 A HU0401596 A HU 0401596A HU P0401596 A HUP0401596 A HU P0401596A HU P0401596 A2 HUP0401596 A2 HU P0401596A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- independently
- hydrogen atom
- nrdre
- formula
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000732 arylene group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005549 heteroarylene group Chemical group 0.000 abstract 2
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A jelen találmány tárgya (I) általános képletű összekapcsoltglikopeptid-kefalosporin származékok és azok gyógyászatilagelfogadható sói, amelyek hatásos antibiotikumok. A jelen találmánytárgya továbbá ilyen vegyületeket tartalmazó gyógyszerkészítmények;ilyen vegyületek alkalmazása emlősök bakteriális fertőzéseinekkezelésénél; valamint ilyen vegyületek előállítására alkalmazhatóeljárások és közbenső termékek. Az (I) általános képetben X1 és X2jelentése egymástól függetlenül hidrogénatom vagy klóratom; R1jelentése -Ya-(W)n-Yb- általános képletű csoport; W jelentése -O-, -N(Rd)-, -S-, -S(O)-, -S(O)2- képletű csoport, 3-6 szénatomoscikloalkilén-, 6-10 szénatomos arilén- vagy 2-9 szénatomosheteroarilén-csoport; ahol az arilén-, cikloalkilén- és heteroarilén-csoportok adott esetben, egyaránt egy és három közötti számú Rbképletű csoporttal helyettesítettek; Ya és Yb jelentése egymástólfüggetlenül 1-5 szénatomos alkiléncsoport, vagy ha W jelentésecikloalkilén-, arilén- vagy heteroarilén-csoport, akkor Ya és Ybjelentése egymástól függetlenül kovalens kötés vagy 1-5 szénatomosalkiléncsoport; R2 jelentése hidrogénatom vagy 1-6 szénatomosalkilcsoport; mindegyik R3 jelentése egymástól függetlenül 1-6szénatomos alkil-, 2-6 szénatomos alkenil-, 2-6 szénatomos alkinil-,3-6 szénatomos cikloalkil-, 6-10 szénatomos aril-, 2-9 szénatomosheteroarilcsoport, 3-6 szénatomos heterogyűrűs csoport vagy Ra képletűcsoport; R4 és R5 közül az egyik hidroxilcsoport, a másik pedighidrogénatom; R6 és R7 jelentése egymástól függetlenül hidrogénatomvagy metilcsoport; R8 jelentése hidrogénatom vagy (i) képletű csoport;mindegyik Ra jelentése egymástól függetlenül -ORd képletű csoport,halogénatom, -SRd, -S(O)Rd, -S(O)2Rd, -S(O)2NRdRe, -NRdRe, -CO2Rd, -OC(O)Rd, -C(O)NRdRe, -NRdC(O)Re, -OC(O)NRdRe, -NRdC(O)ORe, -NRdC(O)NRdRe, -CF3 vagy -OCF3 képletű csoport; Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32888901P | 2001-10-12 | 2001-10-12 | |
| US60/328,889 | 2001-10-12 | ||
| PCT/US2002/032534 WO2003031449A2 (en) | 2001-10-12 | 2002-10-11 | Cross-linked glycopeptide-cephalosporin antibiotics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0401596A2 true HUP0401596A2 (hu) | 2004-12-28 |
| HUP0401596A3 HUP0401596A3 (en) | 2013-06-28 |
| HU230158B1 HU230158B1 (hu) | 2015-09-28 |
Family
ID=23282891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401596A HU230158B1 (hu) | 2001-10-12 | 2002-10-11 | Összekapcsolt glikopeptid-kefalosporin antibiotikumok |
Country Status (30)
| Country | Link |
|---|---|
| US (11) | US6974797B2 (hu) |
| EP (1) | EP1434779B1 (hu) |
| JP (3) | JP4249023B2 (hu) |
| KR (1) | KR100888660B1 (hu) |
| CN (2) | CN100358901C (hu) |
| AT (1) | ATE314376T1 (hu) |
| AU (1) | AU2002332111B2 (hu) |
| BR (2) | BR0213154A (hu) |
| CA (1) | CA2463544C (hu) |
| CO (1) | CO5580782A2 (hu) |
| DE (1) | DE60208404T2 (hu) |
| DK (1) | DK1434779T3 (hu) |
| EA (1) | EA007001B1 (hu) |
| ES (1) | ES2254738T3 (hu) |
| HK (1) | HK1066007A1 (hu) |
| HR (1) | HRP20040243B1 (hu) |
| HU (1) | HU230158B1 (hu) |
| IL (2) | IL160846A0 (hu) |
| IS (1) | IS2422B (hu) |
| MX (1) | MXPA04003273A (hu) |
| NO (1) | NO334092B1 (hu) |
| NZ (1) | NZ531576A (hu) |
| PL (1) | PL209757B1 (hu) |
| RS (1) | RS50888B (hu) |
| SI (1) | SI1434779T1 (hu) |
| SK (1) | SK2052004A3 (hu) |
| TW (1) | TWI335332B (hu) |
| UA (1) | UA80098C2 (hu) |
| WO (1) | WO2003031449A2 (hu) |
| ZA (1) | ZA200402732B (hu) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI335332B (en) * | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
| ATE556088T1 (de) * | 2002-05-24 | 2012-05-15 | Theravance Inc | Konjugat beinhaltend cephalosporin und glykopeptidantibiotikum |
| DE602004024393D1 (de) | 2003-05-23 | 2010-01-14 | Theravance Inc | Quervernetzte glycopeptid-cephalosporin-antibiotika |
| ES2302034T3 (es) * | 2003-07-11 | 2008-07-01 | Theravance, Inc. | Antibioticos de cefalosporina-glicopeptido reticulados. |
| KR100808414B1 (ko) * | 2004-06-08 | 2008-02-29 | 엘지전자 주식회사 | 이동단말의 클라이언트 세션 복구방법 |
| US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
| CA2848012A1 (en) | 2011-09-09 | 2013-03-14 | Cubist Pharmaceuticals, Inc. | Methods for treating intrapulmonary infections |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| AU2014241481B9 (en) * | 2013-03-13 | 2018-02-15 | Theravance Biopharma Antibiotics Ip, Llc | Hydrochloride salts of an antibiotic compound |
| KR20150126368A (ko) * | 2013-03-13 | 2015-11-11 | 세라밴스 바이오파마 안티바이오틱스 아이피, 엘엘씨 | 치환된 티아졸릴 아세트산 트리에틸아민 염의 결정형 |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| US9320740B2 (en) | 2013-03-15 | 2016-04-26 | Merck Sharp & Dohme Corp. | Ceftolozane-tazobactam pharmaceutical compositions |
| CN105392485B (zh) | 2013-03-15 | 2019-08-02 | 默沙东公司 | 头孢特咯瓒抗生素组合物 |
| WO2015035376A2 (en) | 2013-09-09 | 2015-03-12 | Calixa Therapeutics, Inc. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US20150094293A1 (en) | 2013-09-27 | 2015-04-02 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| US10943049B2 (en) * | 2018-09-28 | 2021-03-09 | Taiwan Semiconductor Manufacturing Co., Ltd. | Rule check violation prediction systems and methods |
| NL2023883B1 (en) * | 2019-09-24 | 2021-04-26 | Univ Leiden | Antibiotic compounds |
| WO2023230205A1 (en) | 2022-05-25 | 2023-11-30 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
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