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HUP0400467A2 - 2-Iminopirrolidin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

2-Iminopirrolidin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP0400467A2
HUP0400467A2 HU0400467A HUP0400467A HUP0400467A2 HU P0400467 A2 HUP0400467 A2 HU P0400467A2 HU 0400467 A HU0400467 A HU 0400467A HU P0400467 A HUP0400467 A HU P0400467A HU P0400467 A2 HUP0400467 A2 HU P0400467A2
Authority
HU
Hungary
Prior art keywords
alkyl
hydrogen
compounds
pharmaceutical compositions
group
Prior art date
Application number
HU0400467A
Other languages
English (en)
Inventor
Shuichi Suzuki
Makoto Kotake
Mitsuaki Miyamoto
Tetsuya Kawahara
Akiharu Kajiwara
Ieharu Hishinuma
Kazuo Okano
Syuhei Miyazawa
Richard Clark
Fumihiro Ozaki
Nobuaki Sato
Masanobu Shinoda
Atsushi Kamada
Itaru Tsukada
Fumiyoshi Matsuura
Yoshimitsu Naoe
Taro Terauchi
Yoshiaki Oohashi
Osamu Ito
Hiroshi Tanaka
Takashi Musha
Motoji Kogushi
Tsutomu Kawata
Toshiyuki Matsuoka
Hiroko Kobayashi
Ken-Ichi Chiba
Akifumi Kimura
Naoto Ono
Original Assignee
Eisai Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co., Ltd. filed Critical Eisai Co., Ltd.
Publication of HUP0400467A2 publication Critical patent/HUP0400467A2/hu
Publication of HUP0400467A3 publication Critical patent/HUP0400467A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Lubricants (AREA)

Abstract

A találmány tárgyát képezik az (I) általános képletű 2-iminopirrolidin-származékok, ahol a B jelentése benzolgyűrű,piridingyűrű és hasonlók; R101-R103 jelentése hidrogén-, halogénatom,1-6 szénatomos alkilcsoport és hasonlók; R5 jelentése hidrogénatom, 1-6 szénatomos alkil-, (1-6 szénatomos alkoxi)(1-6 szénatomos alkil)-csoport és hasonlók; R6 jelentése hidrogénatom, 1-6 szilárd anyagalkil-, 1-6 szénatomos alkoxikarbonil-csoport és hasonlók; Y1jelentése vegyértékkötés, -CH2- csoport és hasonlók, Y2 jelentésevegyértékkötés, -CO- csoport és hasonlók; és Ar jelentése hidrogénatomvagy egy (II) általános képletű csoport, ahol R10-R14 jelentésehidrogénatom, 1-6 szénatomos alkil-, hidroxil-, 1-6 szénatomosalkoxicsoport és hasonlók; R11 és R12 vagy R12 és R13 együtt 5-8 tagúheterociklusos gyűrűt alkothat. A találmány a vegyületek sóit, avegyületeket tartalmazó gyógyszerészeti készítményeket és a vegyületekalkalmazását is magában foglalja. Ó
HU0400467A 2001-04-19 2002-04-19 2-iminopyrrolidine derivatives, pharmaceutical compositions containing them and their use HUP0400467A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001121829 2001-04-19
JP2001269422 2001-09-05
PCT/JP2002/003961 WO2002085855A1 (fr) 2001-04-19 2002-04-19 Derives de 2-iminopyrrolidine

Publications (2)

Publication Number Publication Date
HUP0400467A2 true HUP0400467A2 (hu) 2005-02-28
HUP0400467A3 HUP0400467A3 (en) 2012-08-28

Family

ID=26613890

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400467A HUP0400467A3 (en) 2001-04-19 2002-04-19 2-iminopyrrolidine derivatives, pharmaceutical compositions containing them and their use

Country Status (22)

Country Link
US (6) US7476688B2 (hu)
EP (6) EP1391451B1 (hu)
JP (6) JP3795458B2 (hu)
KR (2) KR100749794B1 (hu)
CN (3) CN100402499C (hu)
AT (3) ATE534627T1 (hu)
AU (1) AU2005202135B2 (hu)
BR (1) BR0208985A (hu)
CA (1) CA2446924C (hu)
CZ (1) CZ303865B6 (hu)
DE (2) DE60233043D1 (hu)
ES (1) ES2462995T3 (hu)
HK (1) HK1086269A1 (hu)
HU (1) HUP0400467A3 (hu)
IL (2) IL158491A0 (hu)
MX (1) MXPA03009497A (hu)
NO (1) NO327849B1 (hu)
NZ (1) NZ528820A (hu)
PL (1) PL368109A1 (hu)
RU (1) RU2270192C2 (hu)
WO (4) WO2002085855A1 (hu)
ZA (1) ZA200308064B (hu)

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