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HUE060881T2 - Sóforma az EZH2 gátláshoz - Google Patents

Sóforma az EZH2 gátláshoz

Info

Publication number
HUE060881T2
HUE060881T2 HUE19180479A HUE19180479A HUE060881T2 HU E060881 T2 HUE060881 T2 HU E060881T2 HU E19180479 A HUE19180479 A HU E19180479A HU E19180479 A HUE19180479 A HU E19180479A HU E060881 T2 HUE060881 T2 HU E060881T2
Authority
HU
Hungary
Prior art keywords
salt form
ezh2 inhibition
ezh2
inhibition
salt
Prior art date
Application number
HUE19180479A
Other languages
English (en)
Inventor
Kevin Kuntz
Kuan-Chun Huang
Hyeong Wook Choi
Kristen Sanders
Steven Mathieu
Arani Chanda
Frank Fang
Original Assignee
Epizyme Inc
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme Inc, Eisai R&D Man Co Ltd filed Critical Epizyme Inc
Publication of HUE060881T2 publication Critical patent/HUE060881T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
HUE19180479A 2012-04-13 2013-04-11 Sóforma az EZH2 gátláshoz HUE060881T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261624215P 2012-04-13 2012-04-13

Publications (1)

Publication Number Publication Date
HUE060881T2 true HUE060881T2 (hu) 2023-04-28

Family

ID=49328166

Family Applications (3)

Application Number Title Priority Date Filing Date
HUE13774979A HUE031976T2 (hu) 2012-04-13 2013-04-11 Humán EZH2 hisztonmetil-transzferáz inhibitor só formája
HUE16191716A HUE045353T2 (hu) 2012-04-13 2013-04-11 N-((4,6-dimetil-2-oxo-1,2-dihidropiridin-3-il)-metil)-5-(etil-(tetrahidro-2H-pirán-4-il) -amino)-4-metil-4'-(morfolino-metil)-[1,1'-bifenil]-3-karboxamid-hidrobromid a hematológiai rendszer egy sejtszaporodásos rendellenességének kezelésében való alkalmazásra
HUE19180479A HUE060881T2 (hu) 2012-04-13 2013-04-11 Sóforma az EZH2 gátláshoz

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HUE13774979A HUE031976T2 (hu) 2012-04-13 2013-04-11 Humán EZH2 hisztonmetil-transzferáz inhibitor só formája
HUE16191716A HUE045353T2 (hu) 2012-04-13 2013-04-11 N-((4,6-dimetil-2-oxo-1,2-dihidropiridin-3-il)-metil)-5-(etil-(tetrahidro-2H-pirán-4-il) -amino)-4-metil-4'-(morfolino-metil)-[1,1'-bifenil]-3-karboxamid-hidrobromid a hematológiai rendszer egy sejtszaporodásos rendellenességének kezelésében való alkalmazásra

Country Status (25)

Country Link
US (6) US9394283B2 (hu)
EP (4) EP4190777A1 (hu)
JP (3) JP6255382B2 (hu)
KR (3) KR20220123339A (hu)
CN (2) CN108358899B (hu)
AU (2) AU2013245878B2 (hu)
BR (1) BR112014025508B1 (hu)
CA (1) CA2870005C (hu)
CY (2) CY1119383T1 (hu)
DK (3) DK2836491T3 (hu)
ES (3) ES2617379T3 (hu)
HR (2) HRP20170295T1 (hu)
HU (3) HUE031976T2 (hu)
IL (4) IL282732B2 (hu)
IN (1) IN2014DN09068A (hu)
LT (2) LT3184523T (hu)
MX (1) MX362339B (hu)
NZ (1) NZ700761A (hu)
PL (3) PL3184523T3 (hu)
PT (3) PT3184523T (hu)
RS (2) RS59392B1 (hu)
RU (1) RU2658911C2 (hu)
SG (3) SG11201406468YA (hu)
SI (2) SI3184523T1 (hu)
WO (1) WO2013155317A1 (hu)

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Also Published As

Publication number Publication date
JP6634058B2 (ja) 2020-01-22
CN108358899A (zh) 2018-08-03
US20190269692A1 (en) 2019-09-05
AU2018200168B2 (en) 2019-08-29
SG10201912109QA (en) 2020-02-27
JP2015512942A (ja) 2015-04-30
US20170143729A1 (en) 2017-05-25
US10245269B2 (en) 2019-04-02
JP6255382B2 (ja) 2017-12-27
KR20200066380A (ko) 2020-06-09
ES2617379T3 (es) 2017-06-16
PT3628670T (pt) 2022-12-02
CN108358899B (zh) 2021-07-27
ES2745016T3 (es) 2020-02-27
JP2018199740A (ja) 2018-12-20
IL296199B1 (en) 2024-08-01
SG10201608577RA (en) 2016-12-29
RS59392B1 (sr) 2019-11-29
US9394283B2 (en) 2016-07-19
RS55690B1 (sr) 2017-07-31
EP2836491A1 (en) 2015-02-18
US11491163B2 (en) 2022-11-08
CY1122883T1 (el) 2022-03-24
PL2836491T3 (pl) 2017-08-31
SI2836491T1 (sl) 2017-06-30
US20150065503A1 (en) 2015-03-05
IL235045A0 (en) 2014-12-31
RU2014145544A (ru) 2016-06-10
IL266165B (en) 2021-06-30
SI3184523T1 (sl) 2020-04-30
PT3184523T (pt) 2019-09-26
IL296199A (en) 2022-11-01
IL266165A (en) 2019-06-30
KR20150002730A (ko) 2015-01-07
IL235045B (en) 2019-05-30
EP3184523B1 (en) 2019-06-19
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US20180243316A1 (en) 2018-08-30
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US10821113B2 (en) 2020-11-03
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AU2018200168A1 (en) 2018-02-01
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BR112014025508B1 (pt) 2020-11-17
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