Nothing Special   »   [go: up one dir, main page]

HUE058258T2 - Középagyi dopamin (mda) neuronok in vitro differenciálódásának eljárásai - Google Patents

Középagyi dopamin (mda) neuronok in vitro differenciálódásának eljárásai

Info

Publication number
HUE058258T2
HUE058258T2 HUE16804350A HUE16804350A HUE058258T2 HU E058258 T2 HUE058258 T2 HU E058258T2 HU E16804350 A HUE16804350 A HU E16804350A HU E16804350 A HUE16804350 A HU E16804350A HU E058258 T2 HUE058258 T2 HU E058258T2
Authority
HU
Hungary
Prior art keywords
mda
neurons
methods
vitro differentiation
midbrain dopamine
Prior art date
Application number
HUE16804350A
Other languages
English (en)
Inventor
Lorenz Studer
Stefan Irion
Mark Tomishima
Sonja Kriks
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of HUE058258T2 publication Critical patent/HUE058258T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE16804350A 2015-06-01 2016-06-01 Középagyi dopamin (mda) neuronok in vitro differenciálódásának eljárásai HUE058258T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562169379P 2015-06-01 2015-06-01
US201562169444P 2015-06-01 2015-06-01

Publications (1)

Publication Number Publication Date
HUE058258T2 true HUE058258T2 (hu) 2022-07-28

Family

ID=57441792

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE16804350A HUE058258T2 (hu) 2015-06-01 2016-06-01 Középagyi dopamin (mda) neuronok in vitro differenciálódásának eljárásai

Country Status (17)

Country Link
US (2) US10858625B2 (hu)
EP (3) EP3303564B1 (hu)
JP (4) JP6974180B2 (hu)
KR (3) KR102679619B1 (hu)
AU (2) AU2016270793B2 (hu)
CA (1) CA2987617A1 (hu)
DK (1) DK3303564T3 (hu)
ES (1) ES2910032T3 (hu)
HR (1) HRP20220482T1 (hu)
HU (1) HUE058258T2 (hu)
IL (3) IL313799A (hu)
LT (1) LT3303564T (hu)
PL (1) PL3303564T3 (hu)
PT (1) PT3303564T (hu)
RS (1) RS63157B1 (hu)
SI (1) SI3303564T1 (hu)
WO (1) WO2016196661A1 (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS63157B1 (sr) * 2015-06-01 2022-05-31 Memorial Sloan Kettering Cancer Center Metode in vitro diferencijacije dopaminskih (mda) neurona srednjeg mozga
AU2017214749B2 (en) 2016-02-05 2024-03-28 Memorial Sloan-Kettering Cancer Center Methods of differentiating stem cell-derived ectodermal lineage precursors
ES2901379T3 (es) * 2016-08-16 2022-03-22 Fujifilm Cellular Dynamics Inc Métodos para diferenciar células pluripotentes
KR20190141218A (ko) * 2017-04-26 2019-12-23 메모리얼 슬로안 케터링 캔서 센터 사용 준비된 냉동보존 세포
US12013388B2 (en) * 2017-07-17 2024-06-18 Miltenyi Biotec B.V. & Co. KG Method and kit for single cell protein expression profiling of floorplate mesencephalic dopaminergic progenitor cells
WO2019032680A1 (en) * 2017-08-08 2019-02-14 Regents Of The University Of Minnesota METHODS OF GENERATING AND USING ORGANOIDS AND ASSOCIATED CELLS
US20220243174A1 (en) * 2019-05-23 2022-08-04 The Mclean Hospital Corporation Autologous cell replacement therapy for parkinson`s disease
JP2022549060A (ja) 2019-07-25 2022-11-24 ザ スクリプス リサーチ インスティテュート ドーパミン作動性ニューロン及び前駆細胞を特定する方法
WO2021042027A1 (en) * 2019-08-29 2021-03-04 Memorial Sloan-Kettering Cancer Center Methods of generating and isolating midbrain dopamine neurons
AU2020350408A1 (en) * 2019-09-20 2022-04-07 Korea Research Institute Of Bioscience And Biotechnology Production method for induced dopaminergic neuronal progenitors, using direct reprogramming
BR112022019060A2 (pt) 2020-03-25 2022-11-29 Sana Biotechnology Inc Células neurais hipoimunogênicas para o tratamento de distúrbios e condições neurológicas
WO2021216622A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
WO2021216623A1 (en) 2020-04-21 2021-10-28 Aspen Neuroscience, Inc. Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
US12104170B2 (en) * 2020-06-26 2024-10-01 Minerva Biotechnologies Corporation Methods for deriving dopaminergic neurons from pluripotent stem cells
CN116635047A (zh) * 2020-06-26 2023-08-22 米纳瓦生物技术公司 用于从多能干细胞衍生多巴胺能神经元的方法
KR20230165846A (ko) * 2021-04-07 2023-12-05 후지필름 셀룰러 다이내믹스, 인코포레이티드 도파민성 전구세포 및 사용 방법
WO2023004370A1 (en) 2021-07-21 2023-01-26 Aspen Neuroscience, Inc. Aav-based modulation of gba1 and related compositions and uses thereof
WO2023004366A1 (en) 2021-07-21 2023-01-26 Aspen Neuroscience, Inc. Transposon-based modulation of gba1 and related compositions and uses thereof
CA3237424A1 (en) 2021-11-12 2023-05-19 Axent Biosciences Inc. Methods for production of functional neurons
US20230377685A1 (en) 2022-04-15 2023-11-23 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60032259D1 (de) 1999-05-06 2007-01-18 Sinai School Medicine Steganographie auf DNA basis
KR100903755B1 (ko) * 2000-05-17 2009-06-18 제론 코포레이션 신경 선조세포 집단
AU2005278897A1 (en) * 2004-09-02 2006-03-09 Neuro Therapeutics Ab Methods and materials relating to enhanced production of dopamine neurons
EP1833496B1 (en) 2004-12-23 2013-07-31 Ethicon, Incorporated Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells
CN103893211A (zh) 2006-03-07 2014-07-02 吉塔·什罗夫 包含人胚胎干细胞和其衍生物的组合物、其使用方法和制备方法
US8535719B2 (en) 2006-07-07 2013-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
WO2010096496A2 (en) 2009-02-17 2010-08-26 Memorial Sloan-Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
WO2011149762A2 (en) 2010-05-25 2011-12-01 Memorial Sloan-Kettering Cancer Center Method of nociceptor differentiantion of human embryonic stem cells and uses thereof
US20110296542A1 (en) 2010-05-28 2011-12-01 Kevin Ka-Wang Wang Exogenous matrix-supported topical application of stem cells to organ surface
US10280398B2 (en) * 2011-11-04 2019-05-07 Memorial Sloan-Kettering Cancer Center Midbrain dopamine (DA) neurons for engraftment
WO2013188744A1 (en) 2012-06-15 2013-12-19 Baylor College Of Medicine Perineurium derived adult stem cells and methods of use
EP3498824A1 (en) 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
KR101696874B1 (ko) * 2013-07-31 2017-01-16 한국생명공학연구원 직접 리프로그래밍을 통한 유도 도파민성 전구세포 제조방법
AU2014303330B2 (en) 2013-08-06 2020-08-27 Takeda Pharmaceutical Company Limited Method for producing dopaminergic neurons
CA2923592A1 (en) * 2013-09-05 2015-03-12 Kyoto University Method for inducing dopamine-producing neural precursor cells from pluripotent stem cells
CA2931334A1 (en) 2013-11-21 2015-05-28 Memorial Sloan-Kettering Cancer Center Specification of functional cranial placode derivatives from human pluripotent stem cells
US9694036B2 (en) * 2014-03-21 2017-07-04 Cellular Dynamics International, Inc. Production of midbrain dopaminergic neurons and methods for the use thereof
RS63157B1 (sr) * 2015-06-01 2022-05-31 Memorial Sloan Kettering Cancer Center Metode in vitro diferencijacije dopaminskih (mda) neurona srednjeg mozga

Also Published As

Publication number Publication date
IL291532A (en) 2022-05-01
JP6974180B2 (ja) 2021-12-01
CA2987617A1 (en) 2016-12-08
US10858625B2 (en) 2020-12-08
IL291532B1 (en) 2024-08-01
KR20180014743A (ko) 2018-02-09
EP3303564A4 (en) 2018-10-31
EP3303564A1 (en) 2018-04-11
PL3303564T3 (pl) 2022-05-09
SI3303564T1 (sl) 2022-07-29
AU2016270793B2 (en) 2022-06-09
JP2020146060A (ja) 2020-09-17
KR102679619B1 (ko) 2024-07-01
AU2016270793A1 (en) 2017-12-14
WO2016196661A1 (en) 2016-12-08
RS63157B1 (sr) 2022-05-31
EP4070803A1 (en) 2022-10-12
KR20220020416A (ko) 2022-02-18
US20210123018A1 (en) 2021-04-29
JP2022031961A (ja) 2022-02-22
IL313799A (en) 2024-08-01
IL255992B (en) 2022-04-01
KR20240101884A (ko) 2024-07-02
JP2023181494A (ja) 2023-12-21
KR102358878B1 (ko) 2022-02-08
EP3303564B1 (en) 2022-02-23
PT3303564T (pt) 2022-06-02
LT3303564T (lt) 2022-05-10
EP4079314A1 (en) 2022-10-26
US20180094242A1 (en) 2018-04-05
ES2910032T3 (es) 2022-05-11
DK3303564T3 (da) 2022-04-04
JP2018522538A (ja) 2018-08-16
HRP20220482T1 (hr) 2022-07-08
US12084679B2 (en) 2024-09-10
AU2022228216A1 (en) 2022-10-06
IL255992A (en) 2018-01-31

Similar Documents

Publication Publication Date Title
IL291532A (en) Processes for in vitro differentiation of midbrain dopamine neurons
EP3238481A4 (en) Method and apparatus of latency measurement for lte-wlan aggregation
DK3119881T3 (da) Production of midbrain dopaminergic neurons and methods for the use thereof
EP3128045A4 (en) Cylinder plating apparatus and method
SG11201610052TA (en) Photo-controlled removal of targets in vitro and in vivo
HK1257761A1 (zh) 用於測量限制的配置的方法和裝置
ZA201703398B (en) Pharmaceutical composition and methods
HK1214767A1 (zh) 片劑形式的藥物組合物及其製造方法
GB201513084D0 (en) Apparatus for measure of quantity and associated method of manufacturing
HK1243400A1 (zh) 維生素d2和d3的改進的生產方法
PT3503885T (pt) Composição farmacêutica e métodos de utilização
GB201412554D0 (en) In vitro mesodermal differentiation
HUP1400543A2 (hu) Eljárás és köztitermék apixaban elõállítására
IL254732A0 (en) In vitro preservation of therapeutic cells
GB201612453D0 (en) Methods and apparatus for measuring deformation
EP3230440A4 (en) Compositions and methods for neuronal differentiation of cells
HUP1500647A2 (en) Intermediate of baricitinib and process for its preparation
GB201416858D0 (en) Methods of in Vitro Oocyte Development
TWM490537U (en) Structure of stand
ZA201608823B (en) Processes for the preparation of azd5363 and novel intermediate used therein
GB201406801D0 (en) MRI Apparatus and methods
GB2526175B (en) Design method and apparatus for the manufacture of an article
GB2533406B (en) Methods and apparatus for manufacture of ophthalmic lenses
AU2014904953A0 (en) Compositions and methods for neuronal differentiation of cells
GB201403177D0 (en) Preparation and analysis of iminosugar acids